Kyushu University Academic Staff Educational and Research Activities Database
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DAISUKE KUGA Last modified date:2024.05.24

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 Reseacher Profiling Tool Kyushu University Pure
Academic Degree
Country of degree conferring institution (Overseas)
Field of Specialization
Malignant brain tumor
Total Priod of education and research career in the foreign country
Research Interests
  • Development of Minimally Invasive Surgical Technique Using Surgical Support Robots
    keyword : Surgical Support Robot
  • Development of a new approach to skull base surgery
    keyword : skull base surgery
  • Genetic analysis of malignant brain tumor
    Development of endoscopic surgical method for skull base lesion.
    keyword : brain tumor
Academic Activities
1. Osamu Togao, Hiwatashi Akio, Koji Yamashita, kazufumi kikuchi, Daichi Momosaka, Koji Yoshimoto, Daisuke Kuga, Masahiro Mizoguchi, Satoshi Suzuki, Toru Iwaki, Marc Van Cauteren, Koji Iihara, Hiroshi Honda, Measurement of the perfusion fraction in brain tumors with intravoxel incoherent motion MR imaging
Validation with histopathological vascular density in meningiomas, British Journal of Radiology, 10.1259/bjr.20170912, 91, 1085, 2018.01, Objective: To evaluate the quantification performance of the perfusion fraction (f) measured with intravoxel incoherent motion (IVIM) MR imaging in a comparison with the histological vascular density in meningiomas. Methods: 29 consecutive patients with meningioma (59.0 ± 16.8 years old, 8 males and 21 females) who underwent a subsequent surgical resection were examined with both IVIM imaging and a histopathological analysis. IVIM imaging was conducted using a singleshot SE-EPI sequence with 13 b-factors (0, 10, 20, 30, 50, 80, 100, 200, 300, 400, 600, 800, 1000 s mm-2) at 3T. The perfusion fraction (f) was calculated by fitting the IVIM bi-exponential model. The 90-percentile f-value in the tumor region-of-interest (ROI) was defined as the maximum f-value (f-max). Histopathological vascular density (%Vessel) was measured on CD31-immunostainted histopathological specimens. The correlation and agreement between the f-values and %Vessel was assessed. Results: The f-max (15.5 ± 5.5%) showed excellent agreement [intraclass correlation coefficient (ICC) = 0.754] and a significant correlation (r = 0.69, p
1. Daisuke Kuga, Clinical significance of salvage surgery for recurrent IDH-mutant and 1p/19q-codeleted oligodendroglial tumor., ASNO, 2017.11.