Kyushu University Academic Staff Educational and Research Activities Database
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Takai Shingo Last modified date:2023.06.23

Assistant Professor / Oralneuroscience Section
Department of Dental Science
Faculty of Dental Science

Graduate School
Undergraduate School

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Academic Degree
Ph. D. in Dental science, Kyushu University
Country of degree conferring institution (Overseas)
Field of Specialization
Total Priod of education and research career in the foreign country
Outline Activities
My primary research interest is to understand the perception, transmission, and modulation of taste sensation. I am tackling to exam the taste transduction mechanism and development of mammal taste tissue.
Research Interests
  • The gastrointestinal hormones and their receptors in the peripheral taste tissue
    keyword : taste
  • Transmission and regulation of taste sense
    keyword : Taste Physiology
Academic Activities
1. Takai Shingo, Ryusuke Yoshida, Noriatsu Shigemura, Yuzo Ninomiya, CHEMOSENSORY TRANSDUCTION: DETECTION OF ODOR, TASTE AND OTHER CHEMOSTIMULI, Elsevier, Chapter 17: Peptide signaling in taste transduction
edited by Frank Zufall and Steven D. Munger, 2016.03.
1. Shingo Takai, Yu Watanabe, Keisuke Sanematsu, Ryusuke Yoshida, Robert F. Margolskee, Peihua Jiang, Ikiru Atsuta, Kiyoshi Koyano, Yuzo Ninomiya, Noriatsu Shigemura, Effects of insulin signaling on mouse taste cell proliferation, PloS one, 10.1371/journal.pone.0225190, 14, 11, 2019.11, Expression of insulin and its receptor (IR) in rodent taste cells has been proposed, but exactly which types of taste cells express IR and the function of insulin signaling in taste organ have yet to be determined. In this study, we analyzed expression of IR mRNA and protein in mouse taste bud cells in vivo and explored its function ex vivo in organoids, using RT-PCR, immunohistochemistry, and quantitative PCR. In mouse taste tissue, IR was expressed broadly in taste buds, including in type II and III taste cells. With using 3-D taste bud organoids, we found insulin in the culture medium significantly decreased the number of taste cell and mRNA expression levels of many taste cell genes, including nucleoside triphosphate diphosphohydrolase-2 (NTPDase2), Tas1R3 (T1R3), gustducin, carbonic anhydrase 4 (CA4), glucose transporter-8 (GLUT8), and sodium-glucose cotransporter-1 (SGLT1) in a concentration-dependent manner. Rapamycin, an inhibitor of mechanistic target of rapamycin (mTOR) signaling, diminished insulin’s effects and increase taste cell generation. Altogether, circulating insulin might be an important regulator of taste cell growth and/or proliferation via activation of the mTOR pathway..
1. 髙井 信吾, 重村 憲徳, 井上 真由子, 岩田 周介, 吉田 竜介, 二ノ宮 裕三, Robert F. Margolskee, Glucagon like peptide-1, sweet taste and metabolic modulation of peripheral taste information, 17th International Symposium on Olfaction and Taste (ISOT2016), 2016.07.
Membership in Academic Society
  • Japanese Association for Oral Biology
  • The Japanese Association for the Study of Taste and Smell
  • Best Paper Award at the 49th Annual Meeting of the Japanese Association for the Study of Taste and Smell (2015)
  • Best Poster Award at the 55th Annual Meeting of Japanese Association for Oral Biology (2013)
Educational Activities
In charge of Oral physiology (lecture and practical training) for the undergraduate students.
Conducting the Early Exposure and Research Exposure programs for the undergraduate students.
Train the graduate students in Ph. D course of dental science.
Other Educational Activities
  • 2016.04.