Kyushu University Academic Staff Educational and Research Activities Database
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Kawashiri Takehiro Last modified date:2020.03.23

Assistant Professor / Clinical Pharmacy and Pharmaceutical Care
Department of Pharmaceutical Health Care and Sciences
Faculty of Pharmaceutical Sciences

Graduate School
Undergraduate School
Other Organization

 Reseacher Profiling Tool Kyushu University Pure
臨床育薬学分野ホームページ .
Academic Degree
Country of degree conferring institution (Overseas)
Field of Specialization
Clinical Pharmaceutical Sciences
Total Priod of education and research career in the foreign country
Research Interests
  • Anticancer drugs-induced peripheral neuropathy
    keyword : anticancer drugs, peripheral neuropathy
  • Adverse drug reactions and appropriate use of medication
    keyword : Adverse drug reactions (ADR)
Academic Activities
1. Yano T, Itoh Y, Matsuo M, Kawashiri T, Egashira N, Oishi R, Involvement of both tumor necrosis factor-alpha-induced necrosis and p53-mediated caspase-dependent apoptosis in nephrotoxicity of cisplatin, APOPTOSIS, 10.1007/s10495-007-0110-8, 12, 10, 1901-1909, 2007.10.
2. Kawashiri T, Egashira N, Itoh Y, Shimazoe T, Ikegami Y, Yano T, Yoshimura M, Oishi R, Neurotropin reverses paclitaxel-induced neuropathy without affecting anti-tumour efficacy, EUROPEAN JOURNAL OF CANCER, 10.1016/j.ejca.2008.10.004, 45, 1, 154-163, 2009.01.
3. Sakurai M, Egashira N, Kawashiri T, Yano T, Ikesue H, Oishi R, Oxaliplatin-induced neuropathy in the rat: Involvement of oxalate in cold hyperalgesia but not mechanical allodynia, PAIN, 10.1016/j.pain.2009.09.003, 147, 1-3, 165-174, 2009.12.
4. Egashira N, Hirakawa S, Kawashiri T, Yano T, Ikesue H, Oishi R, Mexiletine reverses oxaliplatin-induced neuropathic pain in rats, JOURNAL OF PHARMACOLOGICAL SCIENCES, 10.1254/jphs.10012SC, 112, 4, 473-476, 2010.04.
5. Mihara Y, Egashira N, Sada H, Kawashiri T, Ushio S, Yano T, Ikesue H, Oishi R, Involvement of spinal NR2B-containing NMDA receptors in oxaliplatin-induced mechanical allodynia in rats, MOLECULAR PAIN, 10.1186/1744-8069-7-8, 7, 2011.01.
6. Tatsushima Y, Egashira N, Kawashiri T, Mihara Y, Yano T, Mishima K, Oishi R, Involvement of substance P in peripheral neuropathy induced by paclitaxel but not oxaliplatin, JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 10.1124/jpet.110.175976, 337, 1, 226-235, 2011.04.
7. Kawashiri T, Egashira N, Watanabe H, Ikegami Y, Hirakawa S, Mihara Y, Yano T, Ikesue H, Oishi R, Prevention of oxaliplatin-induced mechanical allodynia and neurodegeneration by neurotropin in the rat model, EUROPEAN JOURNAL OF PAIN, 10.1016/j.ejpain.2010.08.006, 15, 4, 344-350, 2011.04.
8. Tatsushima Y, Egashira N, Matsushita N, Kurobe K, Kawashiri T, Yano T, Oishi R, Pemirolast reduces cisplatin-induced kaolin intake in rats, EUROPEAN JOURNAL OF PHARMACOLOGY, 10.1016/j.ejphar.2011.04.026, 661, 1-3, 57-62, 2011.07.
9. Yamashita Y, Egashira N, Masuguchi K, Ushio S, Kawashiri T, Oishi R, Comparison of peripheral neuropathy induced by standard and nanoparticle albumin-bound paclitaxel in rats, JOURNAL OF PHARMACOLOGICAL SCIENCES, 10.1254/jphs.11062SC, 117, 2, 116-120, 2011.10.
10. Kawashiri T, Egashira N, Kurobe K, Tsutsumi K, Yamashita Y, Ushio S, Yano T, Oishi R, L type Ca2+ channel blockers prevent oxaliplatin-induced cold hyperalgesia and TRPM8 overexpression in rats, MOLECULAR PAIN, 10.1186/1744-8069-8-7, 8, 2012.01.
11. Shirahama M, Ushio S, Egashira N, Yamamoto S, Sada H, Masuguchi K, Kawashiri T, Oishi R, Inhibition of Ca2+/Calmodulin-dependent protein kinase II reverses oxaliplatin-induced mechanical allodynia in Rats, MOLECULAR PAIN, 10.1186/1744-8069-8-26, 8, 2012.04.
12. Sada H, Egashira N, Ushio S, Kawashiri T, Shirahama M, Oishi R, Repeated Administration of Amitriptyline Reduces Oxaliplatin-Induced Mechanical Allodynia in Rats, JOURNAL OF PHARMACOLOGICAL SCIENCES, 10.1254/jphs.12006SC, 118, 4, 547-551, 2012.04.
13. Ushio S, Egashira N, Sada H, Kawashiri T, Shirahama M, Masuguchi K, Oishi R, Goshajinkigan reduces oxaliplatin-induced peripheral neuropathy without affecting anti-tumour efficacy in rodents, EUROPEAN JOURNAL OF CANCER, 10.1016/j.ejca.2011.08.009, 48, 9, 1407-1413, 2012.06.
14. Yamada T, Nonaka T, Yano T, Kubota T, Egashira N, Kawashiri T, Oishi R, Simplified dosing regimens of teicoplanin for patient groups stratified by renal function and weight using Monte Carlo simulation, INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, 10.1016/j.ijantimicag.2012.05.025, 40, 4, 344-348, 2012.10.
15. Tatsushima Y, Egashira N, Narishige Y, Fukui S, Kawashiri T, Yamauchi Y, Oishi R, Calcium channel blockers reduce oxaliplatin-induced acute neuropathy: A retrospective study of 69 male patients receiving modified FOLFOX6 therapy, BIOMEDICINE & PHARMACOTHERAPY, 10.1016/j.biopha.2012.10.006, 67, 1, 39-42, 2013.02.
16. Tsutsumi K, Yamashita Y, Ushio S, Kawashiri T, Kaname T, Fujita S, Oishi R, Egashira N, Oxaliplatin induces hypomyelination and reduced neuregulin 1 expression in the rat sciatic nerve, NEUROSCIENCE RESEARCH, 10.1016/j.neures.2014.02.004, 80, 86-90, 2014.03.
17. Masuguchi K, Watanabe H, Kawashiri T, Ushio S, Ozawa N, Morita H, Oishi R, Egashira N, Neurotropin (R) relieves oxaliplatin-induced neuropathy via G(i) protein-coupled receptors in the monoaminergic descending pain inhibitory system, LIFE SCIENCES, 10.1016/j.lfs.2013.12.229, 98, 1, 49-54, 2014.03.
18. Yamada T, Kubota T, Nakamura M, Ochiai M, Yonezawa M, Yano T, Kawashiri T, Egashira N, Hara T, Masuda S, Evaluation of teicoplanin concentrations and safety analysis in neonates, INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, 10.1016/j.ijantimicag.2014.07.005, 44, 5, 458-462, 2014.11.
19. Tsuji T, Irisa T, Tagawa S, Kawashiri T, Ikesue H, Kokubu C, Kanaya A, Egashira N, Masuda S, Differences in recognition of similar medication names between pharmacists and nurses: a retrospective study, J PHARMA HEALTH CARE SCI, 1, 19, 2015.07.
20. Yamamoto S, Kawashiri T, Higuchi H, Tsutsumi K, Ushio S, Kaname T, Shirahama M, Egashira N, Behavioral and pharmacological characteristics of bortezomib-induced peripheral neuropathy in rats, JOURNAL OF PHARMACOLOGICAL SCIENCES, 10.1016/j.jphs.2015.08.006, 129, 1, 43-50, 2015.09.
21. Higuchi H, Yamamoto S, Ushio S, Kawashiri T, Egashira N, Goshajinkigan reduces bortezomib-induced mechanical allodynia in rats: Possible involvement of kappa opioid receptor, JOURNAL OF PHARMACOLOGICAL SCIENCES, 10.1016/j.jphs.2015.09.004, 129, 3, 196-199, 2015.11.
22. Fujita S, Ushio S, Ozawa N, Masuguchi K, Kawashiri T, Oishi R, Egashira N, Exenatide Facilitates Recovery from Oxaliplatin-Induced Peripheral Neuropathy in Rats, PLOS ONE, 10.1371/journal.pone.0141921, 10, 11, 2015.11.
23. Tsutsumi K, Kaname T, Shiraishi H, Kawashiri T, Egashira N, Polaprezinc reduces paclitaxel-induced peripheral neuropathy in rats without affecting anti-tumor activity, JOURNAL OF PHARMACOLOGICAL SCIENCES, 10.1016/j.jphs.2016.04.019, 131, 2, 146-149, 2016.06.
24. Yamamoto S, Ushio S, Egashira N, Kawashiri T, Mitsuyasu S, Higuchi H, Ozawa N, Masuguchi K, Ono Y, Masuda S, Excessive spinal glutamate transmission is involved in oxaliplatin-induced mechanical allodynia: a possibility for riluzole as a prophylactic drug, SCIENTIFIC REPORTS, 10.1038/s41598-017-08891-1, 7, 1, 9661, 2017.08.
25. Kawashiri T, Miyagi A, Shimizu S, Shigematsu N, Kobayashi D, Shimazoe T, Dimethyl fumarate ameliorates chemotherapy agent-induced neurotoxicity in vitro, JOURNAL OF PHARMACOLOGICAL SCIENCES, 37:202-211., 2018.07.
26. Miyagi A*, Kawashiri T*, Shimizu S, Shigematsu N, Kobayashi D, Shimazoe T (*equal contribution), Dimethyl fumarate attenuates oxaliplatin-induced peripheral neuropathy without affecting the anti-tumor activity of oxaliplatin in rodents, BIOLOGICAL AND PHARMACEUTICAL BULLETIN, 42, 4, 638-644, 2019.04.
27. Kawashiri T, Shimizu S, Shigematsu N, Kobayashi D, Shimazoe T, Donepezil ameliorates oxaliplatin-induced peripheral neuropathy via a neuroprotective effect, JOURNAL OF PHARMACOLOGICAL SCIENCES, 42:638-644., 2019.05.
28. Kawashiri T, Tokunaga A, Kobayashi D, Shimazoe T., Anti-tumor activities of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors and bisphosphonates in pancreatic cell lines which show poor responses to gemcitabine, BIOLOGICAL AND PHARMACEUTICAL BULLETIN, 43:49–52. , 2020.01.
29. Ishida S, Masuguchi K, Kawashiri T, Tsuji T, Watanabe H, Akiyoshi S, Kubo M, Masuda S, Egashira N., Effects of diluent volume and administration time on the incidence of anaphylaxis following docetaxel therapy in breast cancer​, BIOLOGICAL AND PHARMACEUTICAL BULLETIN (in press), 2020.01.
30. Shigematsu N*, Kawashiri T*, Kobayashi D, Shimizu S, Mine K, Hiromoto S, Uchida M, Egashira N, Shimazoe T. (*equal contribution), Neuroprotective effect of alogliptin on oxaliplatin-induced peripheral neuropathy in vivo and in vitro, SCIENTIFIC REPORTS (in press), 2020.03.
1. Kawashiri T, Tsutsumi K, Ushio S, Egashira N, Masuda S, Prophylactic effect of calcium channel blockers against oxaliplatin-induced acute peripheral neuropathy., Experimental Biology 2014, 2014.04.
2. Kawashiri T, Miyagi A, Shimizu S, Shigematsu N, Kobayashi D, Shimazoe S., Dimethyl fumarate ameliorates chemotherapy agent-induced peripheral neuropathy, WCP2018 the 18th World Congress of Basic and Clinical Pharmacology , 2018.07.
Other Educational Activities
  • 2019.04.
  • 2018.04.
  • 2017.04.
  • 2017.01.
  • 2019.02.
  • 2018.10.
  • 2018.07.
  • 2018.01.