Kyushu University Academic Staff Educational and Research Activities Database
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Kawashiri Takehiro Last modified date:2022.01.05

Assistant Professor / Clinical Pharmacy and Pharmaceutical Care
Department of Pharmaceutical Health Care and Sciences
Faculty of Pharmaceutical Sciences

Graduate School
Undergraduate School
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 Reseacher Profiling Tool Kyushu University Pure
臨床育薬学分野ホームページ .
Academic Degree
Country of degree conferring institution (Overseas)
Field of Specialization
Clinical Pharmaceutical Sciences
ORCID(Open Researcher and Contributor ID)
Total Priod of education and research career in the foreign country
Research Interests
  • Chemotherapy-induced peripheral neuropathy
    keyword : anticancer drugs, peripheral neuropathy
  • Chemotherapy-induced hand-foot syndrome
    keyword : anticancer drugs, hand-foot syndrome
  • Adverse drug reactions and appropriate use of medication
    keyword : Adverse drug reactions (ADR)
Academic Activities
1. Kawashiri T, Inoue M, Mori K, Kobayashi D, Mine K, Ushio S, Kudamatsu H, Uchida M, Egashira N, Shimazoe T, Preclinical and clinical evidence of therapeutic agents for paclitaxel‐induced peripheral neuropathy, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 2021;22:8733., 2021.08.
2. Kawashiri T, Mine K, Kobayashi D, Inoue M, Ushio S, Uchida M, Egashira N, Shimazoe T, Therapeutic agents for oxaliplatin-induced peripheral neuropathy; experimental and clinical evidence, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 2021;22:1393., 2021.02.
1. Kawashiri T, Kobayashi D, Uchida M, Hiromoto S, Inoue M, Ikeda H, Inoue M, Shimazoe T., Analysis of secondary leukemia and myelodysplastic syndrome after chemotherapy for solid organ tumors using the Food and Drug Administration Adverse Event Reporting System (FAERS), JOURNAL OF PHARMACY & PHARMACEUTICAL SCIENCES, 24, 499-508, 2021.10.
2. Egashira N, Goto Y, Takahashi R, Iba H, Yamamoto S, Watanabe T, Kubota K, Kawashiri T, Taniguchi C, Katsurabayashi S, Iwasaki K, Ibudilast suppresses oxaliplatin-induced mechanical allodynia and neurodegeneration in rats, JOURNAL OF PHARMACOLOGICAL SCIENCES, 147, 1, 114-117, 2021.07.
3. Hiromoto S, Kawashiri T, Yamanaka N, Kobayashi D, Mine K, Inoue M, Uchida M, Shimazoe T, Use of omeprazole, the proton pump inhibitor, as a potential therapy for the capecitabine-induced hand-foot syndrome, SCIENTIFIC REPORTS, 11, 1, 8964, 2021.04.
4. Nakamura H, Kawashiri T, Kobayashi D, Uchida M, Egashira N, Shimazoe T, Analgesic effects of Sokeikakketsuto on chemotherapy-induced mechanical allodynia and cold hyperalgesia in rats, BIOLOGICAL AND PHARMACEUTICAL BULLETIN, 44, 2, 271-274, 2021.02.
5. Uchida M, Kawashiri T, Maegawa N, Takano A, Hosohata K, Uesawa Y, Pharmacovigilance evaluation of bendamustine-related skin disorders using the Japanese Adverse Drug Event Report database, JOURNAL OF PHARMACY & PHARMACEUTICAL SCIENCES, 24, 16-22, 2021.01.
6. Shin K, Kobayashi D, Kawashiri T, Ushijima Y, Moritaka K, Yanai H, Ichiki Y, Murakami A, Kanazawa Y, Kamimura H, Shimazoe T, Need for prescription suggestions for long-term inpatients in the psychiatric ward, YAKUGAKU ZASSHI, 140, 8, 1025-1033, Featured article, 2020.08.
7. Kawashiri T, Kobayashi D, Egashira N, Tsuchiya T, Shimazoe T, Oral administration of Cystine and Theanine ameliorates oxaliplatin-induced chronic peripheral neuropathy in rodents, SCIENTIFIC REPORTS, 10, 1, 12665, 2020.07.
8. Ishida S, Masuguchi K, Kawashiri T, Tsuji T, Watanabe H, Akiyoshi S, Kubo M, Masuda S, Egashira N., Effects of diluent volume and administration time on the incidence of anaphylaxis following docetaxel therapy in breast cancer​, BIOLOGICAL AND PHARMACEUTICAL BULLETIN, 434, 4, 663-668, 2020.04.
9. Shigematsu N*, Kawashiri T*, Kobayashi D, Shimizu S, Mine K, Hiromoto S, Uchida M, Egashira N, Shimazoe T. (*equal contribution), Neuroprotective effect of alogliptin on oxaliplatin-induced peripheral neuropathy in vivo and in vitro, SCIENTIFIC REPORTS, 10, 1, 6734, 2020.04.
10. Kawashiri T, Tokunaga A, Kobayashi D, Shimazoe T., Anti-tumor activities of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors and bisphosphonates in pancreatic cell lines which show poor responses to gemcitabine, BIOLOGICAL AND PHARMACEUTICAL BULLETIN, 43:49–52. , 2020.01.
11. Kawashiri T, Shimizu S, Shigematsu N, Kobayashi D, Shimazoe T, Donepezil ameliorates oxaliplatin-induced peripheral neuropathy via a neuroprotective effect, JOURNAL OF PHARMACOLOGICAL SCIENCES, 42:638-644., 2019.05.
12. Miyagi A*, Kawashiri T*, Shimizu S, Shigematsu N, Kobayashi D, Shimazoe T (*equal contribution), Dimethyl fumarate attenuates oxaliplatin-induced peripheral neuropathy without affecting the anti-tumor activity of oxaliplatin in rodents, BIOLOGICAL AND PHARMACEUTICAL BULLETIN, 42, 4, 638-644, 2019.04.
13. Kawashiri T, Miyagi A, Shimizu S, Shigematsu N, Kobayashi D, Shimazoe T, Dimethyl fumarate ameliorates chemotherapy agent-induced neurotoxicity in vitro, JOURNAL OF PHARMACOLOGICAL SCIENCES, 37:202-211., 2018.07.
14. Yamamoto S, Ushio S, Egashira N, Kawashiri T, Mitsuyasu S, Higuchi H, Ozawa N, Masuguchi K, Ono Y, Masuda S, Excessive spinal glutamate transmission is involved in oxaliplatin-induced mechanical allodynia: a possibility for riluzole as a prophylactic drug, SCIENTIFIC REPORTS, 10.1038/s41598-017-08891-1, 7, 1, 9661, 2017.08.
15. Tsutsumi K, Kaname T, Shiraishi H, Kawashiri T, Egashira N, Polaprezinc reduces paclitaxel-induced peripheral neuropathy in rats without affecting anti-tumor activity, JOURNAL OF PHARMACOLOGICAL SCIENCES, 10.1016/j.jphs.2016.04.019, 131, 2, 146-149, 2016.06.
16. Higuchi H, Yamamoto S, Ushio S, Kawashiri T, Egashira N, Goshajinkigan reduces bortezomib-induced mechanical allodynia in rats: Possible involvement of kappa opioid receptor, JOURNAL OF PHARMACOLOGICAL SCIENCES, 10.1016/j.jphs.2015.09.004, 129, 3, 196-199, 2015.11.
17. Fujita S, Ushio S, Ozawa N, Masuguchi K, Kawashiri T, Oishi R, Egashira N, Exenatide Facilitates Recovery from Oxaliplatin-Induced Peripheral Neuropathy in Rats, PLOS ONE, 10.1371/journal.pone.0141921, 10, 11, 2015.11.
18. Yamamoto S, Kawashiri T, Higuchi H, Tsutsumi K, Ushio S, Kaname T, Shirahama M, Egashira N, Behavioral and pharmacological characteristics of bortezomib-induced peripheral neuropathy in rats, JOURNAL OF PHARMACOLOGICAL SCIENCES, 10.1016/j.jphs.2015.08.006, 129, 1, 43-50, 2015.09.
19. Tsuji T, Irisa T, Tagawa S, Kawashiri T, Ikesue H, Kokubu C, Kanaya A, Egashira N, Masuda S, Differences in recognition of similar medication names between pharmacists and nurses: a retrospective study, J PHARMA HEALTH CARE SCI, 1, 19, 2015.07.
20. Yamada T, Kubota T, Nakamura M, Ochiai M, Yonezawa M, Yano T, Kawashiri T, Egashira N, Hara T, Masuda S, Evaluation of teicoplanin concentrations and safety analysis in neonates, INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, 10.1016/j.ijantimicag.2014.07.005, 44, 5, 458-462, 2014.11.
21. Tsutsumi K, Yamashita Y, Ushio S, Kawashiri T, Kaname T, Fujita S, Oishi R, Egashira N, Oxaliplatin induces hypomyelination and reduced neuregulin 1 expression in the rat sciatic nerve, NEUROSCIENCE RESEARCH, 10.1016/j.neures.2014.02.004, 80, 86-90, 2014.03.
22. Masuguchi K, Watanabe H, Kawashiri T, Ushio S, Ozawa N, Morita H, Oishi R, Egashira N, Neurotropin (R) relieves oxaliplatin-induced neuropathy via G(i) protein-coupled receptors in the monoaminergic descending pain inhibitory system, LIFE SCIENCES, 10.1016/j.lfs.2013.12.229, 98, 1, 49-54, 2014.03.
23. Tatsushima Y, Egashira N, Narishige Y, Fukui S, Kawashiri T, Yamauchi Y, Oishi R, Calcium channel blockers reduce oxaliplatin-induced acute neuropathy: A retrospective study of 69 male patients receiving modified FOLFOX6 therapy, BIOMEDICINE & PHARMACOTHERAPY, 10.1016/j.biopha.2012.10.006, 67, 1, 39-42, 2013.02.
24. Yamada T, Nonaka T, Yano T, Kubota T, Egashira N, Kawashiri T, Oishi R, Simplified dosing regimens of teicoplanin for patient groups stratified by renal function and weight using Monte Carlo simulation, INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, 10.1016/j.ijantimicag.2012.05.025, 40, 4, 344-348, 2012.10.
25. Ushio S, Egashira N, Sada H, Kawashiri T, Shirahama M, Masuguchi K, Oishi R, Goshajinkigan reduces oxaliplatin-induced peripheral neuropathy without affecting anti-tumour efficacy in rodents, EUROPEAN JOURNAL OF CANCER, 10.1016/j.ejca.2011.08.009, 48, 9, 1407-1413, 2012.06.
26. Shirahama M, Ushio S, Egashira N, Yamamoto S, Sada H, Masuguchi K, Kawashiri T, Oishi R, Inhibition of Ca2+/Calmodulin-dependent protein kinase II reverses oxaliplatin-induced mechanical allodynia in Rats, MOLECULAR PAIN, 10.1186/1744-8069-8-26, 8, 2012.04.
27. Sada H, Egashira N, Ushio S, Kawashiri T, Shirahama M, Oishi R, Repeated Administration of Amitriptyline Reduces Oxaliplatin-Induced Mechanical Allodynia in Rats, JOURNAL OF PHARMACOLOGICAL SCIENCES, 10.1254/jphs.12006SC, 118, 4, 547-551, 2012.04.
28. Kawashiri T, Egashira N, Kurobe K, Tsutsumi K, Yamashita Y, Ushio S, Yano T, Oishi R, L type Ca2+ channel blockers prevent oxaliplatin-induced cold hyperalgesia and TRPM8 overexpression in rats, MOLECULAR PAIN, 10.1186/1744-8069-8-7, 8, 2012.01.
29. Yamashita Y, Egashira N, Masuguchi K, Ushio S, Kawashiri T, Oishi R, Comparison of peripheral neuropathy induced by standard and nanoparticle albumin-bound paclitaxel in rats, JOURNAL OF PHARMACOLOGICAL SCIENCES, 10.1254/jphs.11062SC, 117, 2, 116-120, 2011.10.
30. Tatsushima Y, Egashira N, Matsushita N, Kurobe K, Kawashiri T, Yano T, Oishi R, Pemirolast reduces cisplatin-induced kaolin intake in rats, EUROPEAN JOURNAL OF PHARMACOLOGY, 10.1016/j.ejphar.2011.04.026, 661, 1-3, 57-62, 2011.07.
31. Tatsushima Y, Egashira N, Kawashiri T, Mihara Y, Yano T, Mishima K, Oishi R, Involvement of substance P in peripheral neuropathy induced by paclitaxel but not oxaliplatin, JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 10.1124/jpet.110.175976, 337, 1, 226-235, 2011.04.
32. Kawashiri T, Egashira N, Watanabe H, Ikegami Y, Hirakawa S, Mihara Y, Yano T, Ikesue H, Oishi R, Prevention of oxaliplatin-induced mechanical allodynia and neurodegeneration by neurotropin in the rat model, EUROPEAN JOURNAL OF PAIN, 10.1016/j.ejpain.2010.08.006, 15, 4, 344-350, 2011.04.
33. Mihara Y, Egashira N, Sada H, Kawashiri T, Ushio S, Yano T, Ikesue H, Oishi R, Involvement of spinal NR2B-containing NMDA receptors in oxaliplatin-induced mechanical allodynia in rats, MOLECULAR PAIN, 10.1186/1744-8069-7-8, 7, 2011.01.
34. Egashira N, Hirakawa S, Kawashiri T, Yano T, Ikesue H, Oishi R, Mexiletine reverses oxaliplatin-induced neuropathic pain in rats, JOURNAL OF PHARMACOLOGICAL SCIENCES, 10.1254/jphs.10012SC, 112, 4, 473-476, 2010.04.
35. Sakurai M, Egashira N, Kawashiri T, Yano T, Ikesue H, Oishi R, Oxaliplatin-induced neuropathy in the rat: Involvement of oxalate in cold hyperalgesia but not mechanical allodynia, PAIN, 10.1016/j.pain.2009.09.003, 147, 1-3, 165-174, 2009.12.
36. Kawashiri T, Egashira N, Itoh Y, Shimazoe T, Ikegami Y, Yano T, Yoshimura M, Oishi R, Neurotropin reverses paclitaxel-induced neuropathy without affecting anti-tumour efficacy, EUROPEAN JOURNAL OF CANCER, 10.1016/j.ejca.2008.10.004, 45, 1, 154-163, 2009.01.
37. Yano T, Itoh Y, Matsuo M, Kawashiri T, Egashira N, Oishi R, Involvement of both tumor necrosis factor-alpha-induced necrosis and p53-mediated caspase-dependent apoptosis in nephrotoxicity of cisplatin, APOPTOSIS, 10.1007/s10495-007-0110-8, 12, 10, 1901-1909, 2007.10.
1. Kawashiri T, Miyagi A, Shimizu S, Shigematsu N, Kobayashi D, Shimazoe S., Dimethyl fumarate ameliorates chemotherapy agent-induced peripheral neuropathy, WCP2018 the 18th World Congress of Basic and Clinical Pharmacology , 2018.07.
2. Kawashiri T, Tsutsumi K, Ushio S, Egashira N, Masuda S, Prophylactic effect of calcium channel blockers against oxaliplatin-induced acute peripheral neuropathy., Experimental Biology 2014, 2014.04.
Other Educational Activities
  • 2020.04.
  • 2019.04.
  • 2018.04.
  • 2017.04.
  • 2017.01.
  • 2019.02.
  • 2018.10.
  • 2018.07.
  • 2018.01.