Faculty Profiles - ISOBE NORIKO

Information

写真a

ISOBE NORIKO

Organization

Faculty of Medical Sciences Neurological Institute Professor
Faculty of Medical Sciences Neurological Institute（Concurrent）
School of Medicine Department of Medicine（Concurrent）
Graduate School of Medical Sciences Department of Medicine（Concurrent）
Graduate School of Medical Sciences Department of Medical Sciences（Concurrent）

Tel

0926425340

Profile

神経内科医として、神経免疫疾患を中心とする神経疾患についての外来・病棟での診療を行いつつ、学部学生への講義や臨床実習での教育や総括、大学院生への研究指導を行っている。研究面では、神経免疫学的研究や臨床疫学研究、遺伝学的研究等を行っている。

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Research Areas

Life Science / Neurology

Degree

MD, PhD

Research History

Kyushu University Graduate School of Medical Sciences Professor

2021.4 - Present

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Country：Japan

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済生会福岡総合病院　神経内科

済生会福岡総合病院　神経内科
University of California San Francisco

Research Interests・Research Keywords

Research theme：genetic study

Keyword：genetic study

Research period： 2024
Research theme：Neuromyelitis optica

Keyword：Neuromyelitis optica

Research period： 2024
Research theme：genotype-phenotype association study

Keyword：genotype-phenotype association study

Research period： 2024
Research theme：HLA

Keyword：HLA

Research period： 2024
Research theme：Genetic determinants of disease susceptibility in multiple sclerosis Genetic determinants of disease progression in multiple sclerosis Genotype-phenotype association studies in multiple sclerosis

Keyword：Multiple sclerosis; Neuromyelitis optica

Research period： 2017.4

Awards

Clinical and Experimental Neuroimmunology (CENI) Best Article Award

2016.9 Clinical and Experimental Neuroimmunology (CENI)
特別研究員（PD）

2014.4 日本学術振興会
海外特別研究員

2012.4 日本学術振興会
Young Neuroimmunologist Award

2011.9
Pan-Asian Committee for Treatment and Research in Multiple Sclerosis (PACTRIMS) Young Investigator Award

2011.8 4th Congress of PACTRIMS

Papers

Safety and Effectiveness of Satralizumab in Japanese Patients with Neuromyelitis Optica Spectrum Disorder: A 6-month Interim Analysis of Post-marketing Surveillance

Takashi Yamamura, Noriko Isobe, Izumi Kawachi, Chiyoko Nohara, Yusei Miyazaki, Minami Tomita, Takahiko Tsumuraya, Katsuhisa Yamashita, Jin Nakahara, Ichiro Nakashima, Kazuo Fujihara

Neurology and Therapy 13 ( 5 ) 1361 - 1383 2024.10 （ ISSN:2193-8253 eISSN:2193-6536 ）

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Language：English Publishing type：Research paper (scientific journal) Publisher：Springer Science and Business Media LLC

DOI： 10.1007/s40120-024-00640-7

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Other Link： https://link.springer.com/article/10.1007/s40120-024-00640-7/fulltext.html
Clinical practice guidelines for multiple sclerosis, neuromyelitis optica spectrum disorder, and myelin oligodendrocyte glycoprotein antibody-associated disease 2023 in Japan

Niino, M; Isobe, N; Araki, M; Ohashi, T; Okamoto, T; Ogino, M; Okuno, T; Ochi, H; Kawachi, I; Shimizu, Y; Takahashi, K; Takeuchi, H; Tahara, M; Chihara, N; Nakashima, I; Fukaura, H; Misu, T; Miyazaki, Y; Miyamoto, K; Mori, M; Kinoshita, M; Takai, Y; Fujii, C; Watanabe, M; Fujihara, K

MULTIPLE SCLEROSIS AND RELATED DISORDERS 90 105829 2024.10 （ ISSN:2211-0348 eISSN:2211-0356 ）

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Language：English Publisher：Multiple Sclerosis and Related Disorders

Background: The previous Japanese clinical practice guidelines for multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD) were published in 2017. Recently, for the first time in 6 years, the MS and NMOSD guideline development committee revised the Japanese guidelines for MS, NMOSD, and myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD). Methods: The committee utilized the Grading of Recommendations Assessment, Development, and Evaluation system based on the “Minds Handbook for Clinical Practice Guideline Development 2020 Ver. 3.0″ with a focus on clinical questions (CQs). The committee also discussed clinical issues other than CQs, categorizing them as a question-and-answer (Q&A) section, including “issues on which experts’ opinions agree to a certain extent” and “issues that are important but not included in the CQ”. Results: The committee identified 3, 1, and 1 key CQs related to MS, NMOSD, and MOGAD, respectively, and presented recommendations. A Q&A session regarding disease-modifying therapies and relapse prevention therapies for MS, NMOSD, and MOGAD was conducted. The revised guidelines were published in September 2023. Conclusions: The Japanese guidelines for clinical practice on MS, NMOSD, and MOGAD were updated. Treatment strategies for MS, NMOSD, and MOGAD are changing, and these updated guidelines may assist with treatment decisions for these diseases in clinical practice.

DOI： 10.1016/j.msard.2024.105829

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A rapidly progressive multiple system atrophy-cerebellar variant model presenting marked glial reactions with inflammation and spreading of α-synuclein oligomers and phosphorylated α-synuclein aggregates. International journal

Hiroo Yamaguchi, Yuji Nishimura, Dai Matsuse, Hiroaki Sekiya, Katsuhisa Masaki, Tatsunori Tanaka, Toru Saiga, Masaya Harada, Yuu-Ichi Kira, Dennis W Dickson, Kei Fujishima, Eriko Matsuo, Kenji F Tanaka, Ryo Yamasaki, Noriko Isobe, Jun-Ichi Kira

Brain, behavior, and immunity 121 122 - 141 2024.10 （ ISSN:0889-1591 eISSN:1090-2139 ）

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Language：English Publishing type：Research paper (scientific journal)

Multiple system atrophy (MSA) is a severe α-synucleinopathy facilitated by glial reactions; the cerebellar variant (MSA-C) preferentially involves olivopontocerebellar fibres with conspicuous demyelination. A lack of aggressive models that preferentially involve olivopontocerebellar tracts in adulthood has hindered our understanding of the mechanisms of demyelination and neuroaxonal loss, and thus the development of effective treatments for MSA. We therefore aimed to develop a rapidly progressive mouse model that recaptures MSA-C pathology. We crossed Plp1-tTA and tetO-SNCA*A53T mice to generate Plp1-tTA::tetO-SNCA*A53T bi-transgenic mice, in which human A53T α-synuclein-a mutant protein with enhanced aggregability-was specifically produced in the oligodendrocytes of adult mice using Tet-Off regulation. These bi-transgenic mice expressed mutant α-synuclein from 8 weeks of age, when doxycycline was removed from the diet. All bi-transgenic mice presented rapidly progressive motor deterioration, with wide-based ataxic gait around 22 weeks of age and death around 30 weeks of age. They also had prominent demyelination in the brainstem/cerebellum. Double immunostaining demonstrated that myelin basic protein was markedly decreased in areas in which SM132, an axonal marker, was relatively preserved. Demyelinating lesions exhibited marked ionised calcium-binding adaptor molecule 1-, arginase-1-, and toll-like receptor 2-positive microglial reactivity and glial fibrillary acidic protein-positive astrocytic reactivity. Microarray analysis revealed a strong inflammatory response and cytokine/chemokine production in bi-transgenic mice. Neuronal nuclei-positive neuronal loss and patchy microtubule-associated protein 2-positive dendritic loss became prominent at 30 weeks of age. However, a perceived decrease in tyrosine hydroxylase-positive neurons in the substantia nigra pars compacta in bi-transgenic mice compared with wild-type mice was not significant, even at 30 weeks of age. Wild-type, Plp1-tTA, and tetO-SNCA*A53T mice developed neither motor deficits nor demyelination. In bi-transgenic mice, double immunostaining revealed human α-synuclein accumulation in neurite outgrowth inhibitor A (Nogo-A)-positive oligodendrocytes beginning at 9 weeks of age; its expression was further increased at 10 to 12 weeks, and these increased levels were maintained at 12, 24, and 30 weeks. In an α-synuclein-proximity ligation assay, α-synuclein oligomers first appeared in brainstem oligodendrocytes as early as 9 weeks of age; they then spread to astrocytes, neuropil, and neurons at 12 and 16 weeks of age. α-Synuclein oligomers in the brainstem neuropil were most abundant at 16 weeks of age and decreased thereafter; however, those in Purkinje cells successively increased until 30 weeks of age. Double immunostaining revealed the presence of phosphorylated α-synuclein in Nogo-A-positive oligodendrocytes in the brainstem/cerebellum as early as 9 weeks of age. In quantitative assessments, phosphorylated α-synuclein gradually and successively accumulated at 12, 24, and 30 weeks in bi-transgenic mice. By contrast, no phosphorylated α-synuclein was detected in wild-type, tetO-SNCA*A53T, or Plp1-tTA mice at any age examined. Pronounced demyelination and tubulin polymerisation, promoting protein-positive oligodendrocytic loss, was closely associated with phosphorylated α-synuclein aggregates at 24 and 30 weeks of age. Early inhibition of mutant α-synuclein expression by doxycycline diet at 23 weeks led to fully recovered demyelination; inhibition at 27 weeks led to persistent demyelination with glial reactions, despite resolving phosphorylated α-synuclein aggregates. In conclusion, our bi-transgenic mice exhibited progressively increasing demyelination and neuroaxonal loss in the brainstem/cerebellum, with rapidly progressive motor deterioration in adulthood. These mice showed marked microglial and astrocytic reactions with inflammation that was closely associated with phosphorylated α-synuclein aggregates. These features closely mimic human MSA-C pathology. Notably, our model is the first to suggest that α-synuclein oligomers may spread from oligodendrocytes to neurons in transgenic mice with human α-synuclein expression in oligodendrocytes. This model of MSA is therefore particularly useful for elucidating the in vivo mechanisms of α-synuclein spreading from glia to neurons, and for developing therapies that target glial reactions and/or α-synuclein oligomer spreading and aggregate formation in MSA.

DOI： 10.1016/j.bbi.2024.07.004

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Three-dimensional magnetic resonance imaging of Baló-like concentric lesion in multiple sclerosis

Iwao, K; Masaki, K; Tanaka, E; Watanabe, M; Kira, Y; Shinoda, K; Matsushita, T; Araki, S; Togao, O; Isobe, N

NEUROLOGY AND CLINICAL NEUROSCIENCE 2024.8 （ ISSN:2049-4173 ）

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Publisher：Neurology and Clinical Neuroscience

DOI： 10.1111/ncn3.12852

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Network Meta-analysis of Ravulizumab and Alternative Interventions for the Treatment of Neuromyelitis Optica Spectrum Disorder (vol 13, pg 535, 2024)

Clardy, SL; Pittock, SJ; Aktas, O; Nakahara, J; Isobe, N; Centonze, D; Fam, S; Kielhorn, A; Yu, JC; Jansen, J; Zhang, I

NEUROLOGY AND THERAPY 13 ( 4 ) 1313 - 1314 2024.8 （ ISSN:2193-8253 eISSN:2193-6536 ）

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Language：English Publisher：Neurology and Therapy

In Fig. 3 of this article, the top row of the Forest plot should show the right end of the confidence interval to align with a value of 0.71; the correct figure is shown below (Fig. 3). (Figure presented.) Forest plot of NMA results for time-to-first relapse with ravulizumab versus alternate interventions in adults with AQP4-Ab+ NMOSD. In SAkuraSky and PREVENT, background IST such as azathioprine, mycophenolate mofetil, and glucocorticoids were allowed, whereas IST was explicitly excluded from the N-MOmentum and SAkuraStar population. AQP4-Ab+ anti-aquaporin-4 antibody-positive, CrI credible interval, IST immunosuppressive therapy, NMOSD neuromyelitis optica spectrum disorder The original article has been corrected.

DOI： 10.1007/s40120-024-00638-1

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A case of monozygotic twins with hereditary spastic paraplegia type 4 and epilepsy, of whom only one developed narcolepsy type 1. International journal

Yuri Mizuno, Taira Uehara, Yuri Nakamura, Toshiki Okadome, Takahiko Mukaino, Kishin Koh, Yoshihisa Takiyama, Takashi Kanbayashi, Noriko Isobe, Jun-Ichi Kira, Hiroyuki Murai, Hiroshi Shigeto

Journal of sleep research 33 ( 4 ) e14102 2024.8 （ ISSN:0962-1105 eISSN:1365-2869 ）

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We report a case of monozygotic twin sisters with hereditary spastic paraplegia type 4 (SPG4) and epilepsy, only one of whom had a diagnosis of narcolepsy type 1 (NT1). The older sister with NT1 exhibited excessive daytime sleepiness, cataplexy, sleep-onset rapid eye movement period in the multiple sleep latency test, and decreased orexin levels in cerebrospinal fluid. Both sisters had HLA-DRB1*15:01-DQB1*06:02 and were further identified to have a novel missense mutation (c.1156A > C, p.Asn386His) in the coding exon of the spastin (SPAST) gene. The novel missense mutation might be involved in the development of epilepsy. This case is characterised by a combined diagnosis of SPG4 and epilepsy, and it is the first report of NT1 combined with epilepsy and genetically confirmed SPG4. The fact that only one of the twins has NT1 suggests that acquired and environmental factors are important in the pathogenesis of NT1.

DOI： 10.1111/jsr.14102

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Oral management for a patient with trismus accompanied by Isaacs' syndrome: a case report

Tani, A; Mizutani, S; Watanabe, M; Irie, T; Masaki, K; Isobe, N; Kashiwazaki, H

BMC ORAL HEALTH 24 ( 1 ) 716 2024.6 （ ISSN:1472-6831 ）

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Language：English Publisher：BMC Oral Health

Background: Isaacs’ syndrome, also known as neuromyotonia or peripheral nerve hyperexcitability, is a rare disorder that affects the peripheral nervous system. Clinical findings include cramps, fasciculations, and myokymia; however, there are few reports of dental treatment for trismus. Case presentation: A patient with trismus due to Isaacs’ syndrome experienced swelling and pain in the gingiva surrounding his right lower first molar. He was diagnosed with chronic apical periodontitis by a dentist near his home. However, the patient was informed that dental treatment and medication could not be administered because of the presence of Isaacs’ syndrome, and he visited the Geriatric Dentistry and Perioperative Oral Care Center at Kyushu University Hospital 2 weeks later. The patient’s painless mouth-opening distance (between incisors) was 20 mm at that time, and medication, including amoxicillin capsules and acetaminophen, was administered because the dental extraction forceps or endodontic instruments were difficult to insert into the oral cavity for treatment. Two months after his initial visit, the patient visited us complaining of pain in the same area. However, he had recently undergone plasmapheresis treatment in neurology to alleviate limited mouth opening and systemic myalgia, resulting in a pain-free mouth-opening distance of approximately 35 mm. During this temporary period in which he had no restriction in mouth opening, we performed tooth extraction and bridge restoration on the mandibular right first molar and created an oral appliance for sleep bruxism. Conclusions: Plasmapheresis therapy transiently reduced trismus, rendering dental interventions feasible, albeit temporarily. This case report underscores the importance of close collaboration between neurologists and dentists who encounter similar cases while furnishing valuable insights to inform dental treatment planning.

DOI： 10.1186/s12903-024-04485-2

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Distinct retinal reflectance spectra from retinal hyperspectral imaging in Parkinson's disease

Ueda, E; Watanabe, M; Nakamura, D; Matsuse, D; Tanaka, E; Fujiwara, K; Hashimoto, S; Nakamura, S; Isobe, N; Sonoda, KH

JOURNAL OF THE NEUROLOGICAL SCIENCES 461 123061 2024.6 （ ISSN:0022-510X eISSN:1878-5883 ）

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Language：English Publisher：Journal of the Neurological Sciences

Background: Recent developments in the retinal hyperspectral imaging method have indicated its potential in addressing challenges posed by neurodegenerative disorders, such as Alzheimer's disease. This human clinical study is the first to assess reflectance spectra obtained from this imaging as a tool for diagnosing patients with Parkinson's disease (PD). Methods: Retinal hyperspectral imaging was conducted on a total of 40 participants, including 20 patients with PD and 20 controls. Following preprocessing, retinal reflectance spectra were computed for the macular retina defined by four rectangular regions. Linear discriminant analysis classifiers underwent training to discern patients with PD from control participants. To assess the performance of the selected features, nested leave-one-out cross-validation was employed using machine learning. The indicated values include the area under the curve (AUC) and the corresponding 95% confidence interval (CI). Results: Retinal reflectance spectra of PD patients exhibited variations in the spectral regions, particularly at shorter wavelengths (superonasal retina, wavelength < 490 nm; inferonasal retina, wavelength < 510 nm) when compared to those of controls. Retinal reflectance spectra yielded an AUC of 0.60 (95% CI: 0.43–0.78) and 0.60 (95% CI: 0.43–0.78) for the superonasal and inferonasal retina, respectively, distinguishing individuals with and without PD. Conclusion: Reflectance spectra obtained from retinal hyperspectral imaging tended to decrease at shorter wavelengths across a broad spectral range in PD patients. Further investigations building upon these preliminary findings are imperative to focus on the retinal spectral signatures associated with PD pathological hallmarks, including α-synuclein.

DOI： 10.1016/j.jns.2024.123061

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Astroglial connexin 43 is a novel therapeutic target for chronic multiple sclerosis model. International journal

Ezgi Ozdemir Takase, Ryo Yamasaki, Satoshi Nagata, Mitsuru Watanabe, Katsuhisa Masaki, Hiroo Yamaguchi, Jun-Ichi Kira, Hideyuki Takeuchi, Noriko Isobe

Scientific reports 14 ( 1 ) 10877 - 10877 2024.5 （ ISSN:2045-2322 ）

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In chronic stages of multiple sclerosis (MS) and its animal model, experimental autoimmune encephalitis (EAE), connexin (Cx)43 gap junction channel proteins are overexpressed because of astrogliosis. To elucidate the role of increased Cx43, the central nervous system (CNS)-permeable Cx blocker INI-0602 was therapeutically administered. C57BL6 mice with chronic EAE initiated by MOG35-55 received INI-0602 (40 mg/kg) or saline intraperitoneally every other day from days post-immunization (dpi) 17-50. Primary astroglia were employed to observe calcein efflux responses. In INI-0602-treated mice, EAE clinical signs improved significantly in the chronic phase, with reduced demyelination and decreased CD3+ T cells, Iba-1+ and F4/80+ microglia/macrophages, and C3+GFAP+ reactive astroglia infiltration in spinal cord lesions. Flow cytometry analysis of CD4+ T cells from CNS tissues revealed significantly reduced Th17 and Th17/Th1 cells (dpi 24) and Th1 cells (dpi 50). Multiplex array of cerebrospinal fluid showed significantly suppressed IL-6 and significantly increased IL-10 on dpi 24 in INI-0602-treated mice, and significantly suppressed IFN-γ and MCP-1 on dpi 50 in the same group. In vitro INI-0602 treatment inhibited ATP-induced calcium propagations of Cx43+/+ astroglial cells to similar levels of those of Cx43-/- cells. Astroglial Cx43 hemichannels represent a novel therapeutic target for chronic EAE and MS.

DOI： 10.1038/s41598-024-61508-2

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Focal 18F‐fluorodeoxyglucose uptake in spinal dural arteriovenous fistula: A report of two cases

Hitoshi Hayashida, Katsuhisa Masaki, Hidenori Ogata, Takahiro Yamaguchi, Koji Tanaka, Koichi Arimura, Yasuhiro Maruoka, Kazufumi Kikuchi, Osamu Togao, Ryo Yamasaki, Noriko Isobe

Neurology and Clinical Neuroscience 12 ( 3 ) 201 - 204 2024.5 （ ISSN:2049-4173 eISSN:2049-4173 ）

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Publishing type：Research paper (scientific journal) Publisher：Wiley

Abstract

Magnetic resonance imaging of spinal dural arteriovenous fistula (SDAVF) shows longitudinally extensive spinal cord lesions mimicking neoplastic or inflammatory myelopathy. On positron emission tomography/computed tomography (PET/CT), we report two patients who showed focal 18F‐fluorodeoxyglucose (FDG) uptake in longitudinally extensive spinal cord lesions. These lesions were indistinguishable from tumors or myelitis but were finally diagnosed as SDAVF. Although PET/CT availability may be limited, in cases of myelopathy with diagnostic challenges, it is important to recognize that focal FDG uptake can be observed in SDAVF.

DOI： 10.1111/ncn3.12794

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Focal 18F-fluorodeoxyglucose uptake in spinal dural arteriovenous fistula: A report of two cases(タイトル和訳中)

Hayashida Hitoshi, Masaki Katsuhisa, Ogata Hidenori, Yamaguchi Takahiro, Tanaka Koji, Arimura Koichi, Maruoka Yasuhiro, Kikuchi Kazufumi, Togao Osamu, Yamasaki Ryo, Isobe Noriko

Neurology and Clinical Neuroscience 12 ( 3 ) 201 - 204 2024.5

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Language：English Publisher：(一社)日本神経学会
A nationwide survey of facial onset sensory and motor neuronopathy in Japan

Senri Ko, Ryo Yamasaki, Tasuku Okui, Wataru Shiraishi, Mitsuru Watanabe, Yu Hashimoto, Yuko Kobayakawa, Susumu Kusunoki, Jun-ichi Kira, Noriko Isobe

Journal of the Neurological Sciences 459 122957 - 122957 2024.4 （ ISSN:0022-510X eISSN:1878-5883 ）

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Language：English Publishing type：Research paper (scientific journal) Publisher：Elsevier BV

DOI： 10.1016/j.jns.2024.122957

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Association between hypothalamic Alzheimer's disease pathology and body mass index: The Hisayama study. International journal

Kaoru Yagita, Hiroyuki Honda, Tomoyuki Ohara, Sachiko Koyama, Hideko Noguchi, Yoshinao Oda, Ryo Yamasaki, Noriko Isobe, Toshiharu Ninomiya

Neuropathology : official journal of the Japanese Society of Neuropathology 44 ( 5 ) 388 - 400 2024.4 （ ISSN:0919-6544 eISSN:1440-1789 ）

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The hypothalamus is the region of the brain that integrates the neuroendocrine system and whole-body metabolism. Patients with Alzheimer's disease (AD) have been reported to exhibit pathological changes in the hypothalamus, such as neurofibrillary tangles (NFTs) and amyloid plaques (APs). However, few studies have investigated whether hypothalamic AD pathology is associated with clinical factors. We investigated the association between AD-related pathological changes in the hypothalamus and clinical pictures using autopsied brain samples obtained from deceased residents of a Japanese community. A total of 85 autopsied brain samples were semi-quantitatively analyzed for AD pathology, including NFTs and APs. Our histopathological studies showed that several hypothalamic nuclei, such as the tuberomammillary nucleus (TBM) and lateral hypothalamic area (LHA), are vulnerable to AD pathologies. NFTs are observed in various neuropathological states, including normal cognitive cases, whereas APs are predominantly observed in AD. Regarding the association between hypothalamic AD pathologies and clinical factors, the degree of APs in the TBM and LHA was associated with a lower body mass index while alive, after adjusting for sex and age at death. However, we found no significant association between hypothalamic AD pathology and the prevalence of hypertension, diabetes, or dyslipidemia. Our study showed that a lower BMI, which is a poor prognostic factor of AD, might be associated with hypothalamic AP pathology and highlighted new insights regarding the disruption of the brain-whole body axis in AD.

DOI： 10.1111/neup.12974

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Progressive myoclonic epilepsy as an expanding phenotype of NGLY1-associated congenital deglycosylation disorder: A case report and review of the literature. International journal

Yuri Sonoda, Atsushi Fujita, Michiko Torio, Takahiko Mukaino, Ayumi Sakata, Masaru Matsukura, Kousuke Yonemoto, Ken Hatae, Yuko Ichimiya, Pin Fee Chong, Masayuki Ochiai, Yoshinao Wada, Machiko Kadoya, Nobuhiko Okamoto, Yoshiko Murakami, Tadashi Suzuki, Noriko Isobe, Hiroshi Shigeto, Naomichi Matsumoto, Yasunari Sakai, Shouichi Ohga

European journal of medical genetics 67 104895 - 104895 2024.2 （ ISSN:1769-7212 eISSN:1878-0849 ）

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INTRODUCTION: NGLY1-associated congenital disorder of deglycosylation (CDDG1: OMIM #615273) is a rare autosomal recessive disorder caused by a functional impairment of endoplasmic reticulum in degradation of glycoproteins. Neurocognitive dysfunctions have been documented in patients with CDDG1; however, deteriorating phenotypes of affected individuals remain elusive. CASE PRESENTATION: A Japanese boy with delayed psychomotor development showed ataxic movements from age 5 years and myoclonic seizures from age 12 years. Appetite loss, motor and cognitive decline became evident at age 12 years. Electrophysiological studies identified paroxysmal discharges on myoclonic seizure and a giant somatosensory evoked potential. Perampanel was effective for controlling myoclonic seizures. Exome sequencing revealed that the patient carried compound heterozygous variants in NGLY1, NM_018297.4: c.857G > A and c.-17_12del, which were inherited from mother and father, respectively. A literature review confirmed that myoclonic seizures were observed in 28.5% of patients with epilepsy. No other patients had progressive myoclonic epilepsy or cognitive decline in association with loss-of-function variations in NGLY1. CONCLUSION: Our data provides evidence that a group of patients with CDDG1 manifest slowly progressive myoclonic epilepsy and cognitive decline during the long-term clinical course.

DOI： 10.1016/j.ejmg.2023.104895

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Multiple dural arteriovenous fistulas showing isolated subcortical white matter T2 hyperintensity with gadolinium enhancement

M.D. Hayashida Hitoshi, M.D. Ph.D. Masaki Katsuhisa, M.D. Ph.D. Ogata Hidenori, M.D. Harada Ayumi, M.D. Ph.D. Arimura Koichi, M.D. Ph.D. Yamasaki Ryo, M.D. Ph.D. Isobe Noriko

Rinsho Shinkeigaku 64 ( 8 ) 572 - 578 2024 （ ISSN:0009918X eISSN:18820654 ）

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Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Societas Neurologica Japonica

We describe a 44-year-old man with a complaint of atonic seizures of the left upper limb, followed by generalized seizures. Brain MRI showed isolated juxtacortical white matter T2 hyperintensity with gadolinium (Gd) enhancement of the adjacent cortical gray matter and subcortical white matter in the right frontal convexity. Treatment with levetiracetam was effective for seizure suppression, and he had no other neurological abnormalities. Human leukocyte antigen typing revealed B54 and Cw1, which indicated the possibility of neuro-Sweet disease. However, a general examination, which included vital signs and eye and skin findings, was normal. A cerebrospinal fluid test showed a mild elevation in protein levels without pleocytosis and a normal range of interleukin-6. Electroencephalography showed intermittent slow waves without epileptic discharge in the bilateral temporal lobes. We detected subtle flow voids in the pia mater of the left frontal lobe, which suggested cerebrovascular disease, and specifically, the possibility of dural arteriovenous fistulas. Computed tomography angiography showed abnormally dilated perimedullary veins in the left frontal lobe. Cerebral angiography confirmed the existence of four dural arteriovenous fistulas, which included two retrograde leptomeningeal venous drainages in the right frontal cortical veins supplied by the anterior branch of the right middle meningeal artery. The other dural arteriovenous fistulas were retrograde leptomeningeal venous drainages in the left frontal cortical veins supplied by the anterior and posterior convexity branches of the left middle meningeal artery. The patient underwent successful endovascular embolization of all dural arteriovenous fistulas with Onyx injection. A follow-up MRI showed gradual improvement of the T2 hyperintensity and Gd enhancement. He remained seizure-free for 2 years following endovascular embolization.

DOI： 10.5692/clinicalneurol.cn-001947

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Gelation of Hydrophilic Polymer Bearing Metal-coordination Unit with Various Metal Ions

Naga, D; Isobe, N; Maki, Y; Okamoto, S

CHEMISTRY LETTERS 52 ( 11 ) 843 - 845 2023.11 （ ISSN:0366-7022 eISSN:1348-0715 ）

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Publisher：Chemistry Letters

Gelation of a hydrophilic polymer bearing a metal-coordination unit with various metal ions was examined. Gels with different morphologies were formed depending on the metal ion species. The formation mechanism for these gels could be explained based on their cross-linking rates. Gelation in two-component solutions containing different ratios of PdII to other metal ions (AuIII and PtIV) was also investigated.

DOI： 10.1246/cl.230347

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Direct neuronal conversion of microglia/macrophages reinstates neurological function after stroke. International journal

Takashi Irie, Taito Matsuda, Yoshinori Hayashi, Kanae Matsuda-Ito, Akihide Kamiya, Takahiro Masuda, Marco Prinz, Noriko Isobe, Jun-Ichi Kira, Kinichi Nakashima

Proceedings of the National Academy of Sciences of the United States of America 120 ( 42 ) e2307972120 2023.10 （ ISSN:0027-8424 eISSN:1091-6490 ）

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Language：English Publishing type：Research paper (scientific journal)

Although generating new neurons in the ischemic injured brain would be an ideal approach to replenish the lost neurons for repairing the damage, the adult mammalian brain retains only limited neurogenic capability. Here, we show that direct conversion of microglia/macrophages into neurons in the brain has great potential as a therapeutic strategy for ischemic brain injury. After transient middle cerebral artery occlusion in adult mice, microglia/macrophages converge at the lesion core of the striatum, where neuronal loss is prominent. Targeted expression of a neurogenic transcription factor, NeuroD1, in microglia/macrophages in the injured striatum enables their conversion into induced neuronal cells that functionally integrate into the existing neuronal circuits. Furthermore, NeuroD1-mediated induced neuronal cell generation significantly improves neurological function in the mouse stroke model, and ablation of these cells abolishes the gained functional recovery. Our findings thus demonstrate that neuronal conversion contributes directly to functional recovery after stroke.

DOI： 10.1073/pnas.2307972120

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Caution to Poor Adherence With Immunosuppressant Medication That Causes Coma-Onset Autoimmune Encephalitis: A Case Report and Literature Review. International journal

Katsuya Toshida, Takeo Toshima, Shinji Itoh, Shohei Yoshiya, Takahiko Mukaino, Takayuki Fujii, Mitsuru Watanabe, Ryo Yamasaki, Noriko Isobe, Tomoharu Yoshizumi

Transplantation proceedings 55 ( 8 ) 1968 - 1971 2023.10 （ ISSN:0041-1345 eISSN:1873-2623 ）

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Autoimmune encephalitis after liver transplantation (LT) is a rare disorder. This is because patients are usually in an immunosuppressed state after LT. Here, we report a rare case of autoantibody-negative autoimmune-encephalitis-induced coma after living-donor (LD) LT. A 45-year-old woman who underwent LDLT for primary biliary cholangitis (PBC) was brought to our hospital with the chief complaint of cognitive deficiency and an episode of memory loss. Physical examination, laboratory tests, and cerebrospinal fluid analysis revealed no significant findings. However, diffusion-weighted magnetic resonance imaging showed hyperintensity in the bilateral hippocampus. No autoantibodies associated with autoimmune encephalitis were detected. The diagnosis of antibody-negative autoimmune encephalitis was made on the basis of low immunosuppressive drug levels in the blood (indicative of poor adherence) and the presence of PBC as the autoimmune disease. The patient regained consciousness after intravenous methylprednisolone pulse therapy and plasma exchange. This case highlights that when examining patients with impaired consciousness after LDLT, it is important to consider autoimmune encephalitis as a potential diagnosis.

DOI： 10.1016/j.transproceed.2023.07.005

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Case series of eculizumab treatment on NMOSD attacks

Watanabe, M; Masaki, K; Tanaka, E; Matsushita, T; Isobe, N

MULTIPLE SCLEROSIS JOURNAL 29 947 - 948 2023.10 （ ISSN:1352-4585 eISSN:1477-0970 ）

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コネキシン30欠損はグリア炎症を抑制することでALSモデルマウスの発症早期の疾患進行を緩和する

橋本侑, 山崎亮, 江千里, 小早川優子, 眞崎勝久, 松瀬大, 松下拓也, 磯部紀子

神経免疫学 28 ( 1 ) 221 - 221 2023.9 （ ISSN:0918-936X ）

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Iguratimod Ameliorates the Severity of Secondary Progressive Multiple Sclerosis in Model Mice by Directly Inhibiting IL-6 Production and Th17 Cell Migration via Mitigation of Glial Inflammation. International journal

Satoshi Nagata, Ryo Yamasaki, Ezgi Ozdemir Takase, Kotaro Iida, Mitsuru Watanabe, Katsuhisa Masaki, Marion Heleen Cathérine Wijering, Hiroo Yamaguchi, Jun-Ichi Kira, Noriko Isobe

Biology 12 ( 9 ) 2023.9 （ ISSN:2079-7737 eISSN:2079-7737 ）

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We previously reported a novel secondary progressive multiple sclerosis (SPMS) model, progressive experimental autoimmune encephalomyelitis (pEAE), in oligodendroglia-specific Cx47-inducible conditional knockout (Cx47 icKO) mice. Based on our prior study showing the efficacy of iguratimod (IGU), an antirheumatic drug, for acute EAE treatment, we aimed to elucidate the effect of IGU on the SPMS animal model. We induced pEAE by immunizing Cx47 icKO mice with myelin oligodendrocyte glycoprotein peptide 35-55. IGU was orally administered from 17 to 50 days post-immunization. We also prepared a primary mixed glial cell culture and measured cytokine levels in the culture supernatant after stimulation with designated cytokines (IL-1α, C1q, TNF-α) and lipopolysaccharide. A migration assay was performed to evaluate the effect of IGU on the migration ability of T cells toward mixed glial cell cultures. IGU treatment ameliorated the clinical signs of pEAE, decreased the demyelinated area, and attenuated glial inflammation on immunohistochemical analysis. Additionally, IGU decreased the intrathecal IL-6 level and infiltrating Th17 cells. The migration assay revealed reduced Th17 cell migration and IL-6 levels in the culture supernatant after IGU treatment. Collectively, IGU successfully mitigated the clinical signs of pEAE by suppressing Th17 migration through inhibition of IL-6 production by proinflammatory-activated glial cells.

DOI： 10.3390/biology12091217

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Granulocyte activation markers in cerebrospinal fluid differentiate acute neuromyelitis spectrum disorder from multiple sclerosis. International journal

David Leppert, Mitsuru Watanabe, Sabine Schaedelin, Fredrik Piehl, Roberto Furlan, Matteo Gastaldi, Jeremy Lambert, Björn Evertsson, Katharina Fink, Takuya Matsushita, Katsuhisa Masaki, Noriko Isobe, Jun-Ichi Kira, Pascal Benkert, Aleksandra Maceski, Eline Willemse, Johanna Oechtering, Annette Orleth, Stephanie Meier, Jens Kuhle

Journal of neurology, neurosurgery, and psychiatry 94 ( 9 ) 726 - 737 2023.9 （ ISSN:0022-3050 eISSN:1468-330X ）

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BACKGROUND: Granulocyte invasion into the brain is a pathoanatomical feature differentiating neuromyelitis optica spectrum disorder (NMOSD) from multiple sclerosis (MS). We aimed to determine whether granulocyte activation markers (GAM) in cerebrospinal fluid (CSF) can be used as a biomarker to distinguish NMOSD from MS, and whether levels associate with neurological impairment. METHODS: We quantified CSF levels of five GAM (neutrophil elastase, myeloperoxidase, neutrophil gelatinase-associated lipocalin, matrixmetalloproteinase-8, tissue inhibitor of metalloproteinase-1), as well as a set of inflammatory and tissue-destruction markers, known to be upregulated in NMOSD and MS (neurofilament light chain, glial fibrillary acidic protein, S100B, matrix metalloproteinase-9, intercellular adhesion molecule-1, vascular cellular adhesion molecule-1), in two cohorts of patients with mixed NMOSD and relapsing-remitting multiple sclerosis (RRMS). RESULTS: In acute NMOSD, GAM and adhesion molecules, but not the other markers, were higher than in RRMS and correlated with actual clinical disability scores. Peak GAM levels occurred at the onset of NMOSD attacks, while they were stably low in MS, allowing to differentiate the two diseases for ≤21 days from onset of clinical exacerbation. Composites of GAM provided area under the curve values of 0.90-0.98 (specificity of 0.76-1.0, sensitivity of 0.87-1.0) to differentiate NMOSD from MS, including all anti-aquaporin-4 protein (aAQP4)-antibody-negative patients who were untreated. CONCLUSIONS: GAM composites represent a novel biomarker to reliably differentiate NMOSD from MS, including in aAQP4- NMOSD. The association of GAM with the degree of concurrent neurological impairment provides evidence for their pathogenic role, in turn suggesting them as potential drug targets in acute NMOSD.

DOI： 10.1136/jnnp-2022-330796

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Exosome Connexin43-Truncated Isoforms and Bound RNAs Distinctively Associated with Multiple Sclerosis and Neuromyelitis Optica Spectrum Disorder

Kira, JI; Maimaitijiang, G; Sakoda, A; Masaki, K; Watanabe, M; Nagata, S; Ozdemir, E; Yamasaki, R; Isobe, N; Zhang, X; Imamura, T; Nakamura, Y

ANNALS OF NEUROLOGY 94 S54 - S55 2023.9 （ ISSN:0364-5134 eISSN:1531-8249 ）

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Locus for severity implicates CNS resilience in progression of multiple sclerosis

Harroud, A; Stridh, P; McCauley, JL; Saarela, J; van den Bosch, AMR; Engelenburg, HJ; Beecham, AH; Alfredsson, L; Alikhani, K; Amezcua, L; Andlauer, TFM; Ban, M; Barcellos, LF; Barizzone, N; Berge, T; Berthele, A; Bittner, S; Bos, SD; Briggs, FBS; Caillier, SJ; Calabresi, PA; Caputo, D; Carmona-Burgos, DX; Cavalla, P; Celius, EG; Cerono, G; Chinea, AR; Chitnis, T; Clarelli, F; Comabella, M; Comi, G; Cotsapas, C; Cree, BCA; D'Alfonso, S; Dardiotis, E; De Jager, PL; Delgado, SR; Dubois, B; Engel, S; Esposito, F; Fabis-Pedrini, MJ; Filippi, M; Fitzgerald, KC; Gasperi, C; Gomez, L; Gomez, R; Hadjigeorgiou, G; Hamann, J; Held, F; Henry, RG; Hillert, J; Huang, JS; Huitinga, I; Islam, T; Isobe, N; Jagodic, M; Kermode, AG; Khalil, M; Kilpatrick, TJ; Konidari, I; Kreft, KL; Lechner-Scott, J; Leone, M; Luessi, F; Malhotra, S; Manouchehrinia, A; Manrique, CP; Martinelli-Boneschi, F; Martinez, AC; Martinez-Maldonado, V; Mascia, E; Metz, LM; Midaglia, L; Montalban, X; Oksenberg, JR; Olsson, T; Oturai, A; Pääkkönen, K; Parnell, GP; Patsopoulos, NA; Pericak-Vance, MA; Piehl, F; Rubio, JP; Santaniello, A; Santoro, S; Schaefer, C; Sellebjerg, F; Shams, H; Shchetynsky, K; Silva, C; Siokas, V; Sondergaard, HB; Sorosina, M; Taylor, B; Vandebergh, M; Vasileiou, ES; Vecchio, D; Voortman, MM; Weiner, HL; Wever, D; Yong, VW; Hafler, DA; Stewart, GJ; Compston, A; Zipp, F; Harbo, HF; Hemmer, B; Goris, A; Smolders, J; Hauser, SL; Kockum, I; Sawcer, SJ; Baranzini, SE; Jónsdóttir, I; Blanco, Y; Llufriu, S; Madireddy, L; Saiz, A; Villoslada, P; Stefánsson, K; Harbo, HF; Hemmer, B; Goris, A; Kockum, I; Sawcer, SJ; Baranzini, SE

NATURE 619 ( 7969 ) 329 - 331 2023.7 （ ISSN:0028-0836 eISSN:1476-4687 ）

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Multiple sclerosis (MS) is an autoimmune disease of the central nervous system (CNS) that results in significant neurodegeneration in the majority of those affected and is a common cause of chronic neurological disability in young adults1,2. Here, to provide insight into the potential mechanisms involved in progression, we conducted a genome-wide association study of the age-related MS severity score in 12,584 cases and replicated our findings in a further 9,805 cases. We identified a significant association with rs10191329 in the DYSF–ZNF638 locus, the risk allele of which is associated with a shortening in the median time to requiring a walking aid of a median of 3.7 years in homozygous carriers and with increased brainstem and cortical pathology in brain tissue. We also identified suggestive association with rs149097173 in the DNM3–PIGC locus and significant heritability enrichment in CNS tissues. Mendelian randomization analyses suggested a potential protective role for higher educational attainment. In contrast to immune-driven susceptibility3, these findings suggest a key role for CNS resilience and potentially neurocognitive reserve in determining outcome in MS.

DOI： 10.1038/s41586-023-06250-x

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Long-lasting pain and somatosensory disturbances in children with myelin oligodendrocyte glycoprotein antibody-associated disease. International journal

Yuko Ichimiya, Pin Fee Chong, Yuri Sonoda, Vlad Tocan, Mitsuru Watanabe, Hiroyuki Torisu, Ryutaro Kira, Toshiyuki Takahashi, Jun-Ichi Kira, Noriko Isobe, Yasunari Sakai, Shouichi Ohga

European journal of pediatrics 182 ( 7 ) 3175 - 3185 2023.7 （ ISSN:0340-6199 eISSN:1432-1076 ）

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UNLABELLED: Myelin oligodendrocyte glycoprotein antibody (MOG-Ab) is an autoantibody associated with acquired demyelinating syndrome (ADS) in childhood and adults. The pathogenic roles of MOG-Ab and long-term outcomes of children with MOG-Ab-associated disease (MOGAD) remain elusive. We investigated the clinical features of children with ADS during follow-up in our institute. Clinical data were retrospectively analyzed using medical charts of patients managed in Kyushu University Hospital from January 1st, 2001, to March 31st, 2022. Participants were children of < 18 years of age when they received a diagnosis of ADS in our hospital. Cell-based assays were used to detect MOG-Ab in serum or cerebrospinal fluid at the onset or recurrence of ADS. The clinical and neuroimaging data of MOG-Ab-positive and MOG-Ab-negative patients were statistically analyzed. Among 31 patients enrolled in this study, 22 (13 females, 59%) received tests for MOG antibodies. Thirteen cases (59%) were MOG-Ab-positive and were therefore defined as MOGAD; 9 (41%) were MOG-Ab-negative. There were no differences between MOGAD and MOG-Ab-negative patients in age at onset, sex, diagnostic subcategories, or duration of follow-up. MOGAD patients experienced headache and/or somatosensory symptoms more frequently than MOG-Ab-negative patients (12/13 (92%) vs. 3/9 (22%); p = 0.0066). Somatosensory problems included persistent pain with hyperesthesia in the left toe, perineal dysesthesia, and facial hypesthesia. No specific neuroimaging findings were associated with MOGAD or the presence of somatosensory symptoms. CONCLUSIONS: Long-lasting somatosensory disturbances are prominent comorbidities in children with MOGAD. Prospective cohorts are required to identify molecular and immunogenetic profiles associated with somatosensory problems in MOGAD. WHAT IS KNOWN: • Recurrence of demyelinating events occurs in a group of children with myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD). WHAT IS NEW: • Long-lasting headache and somatosensory problems are frequent comorbidities with pediatric MOGAD. Pain and somatosensory problems may persist for more than 5 years. • Neuroimaging data do not indicate specific findings in children with somatic disturbances.

DOI： 10.1007/s00431-023-04989-z

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Lineage tracing identifies in vitro microglia-to-neuron conversion by NeuroD1 expression. International journal

Takashi Irie, Kanae Matsuda-Ito, Taito Matsuda, Takahiro Masuda, Marco Prinz, Noriko Isobe, Kinichi Nakashima

Genes to cells : devoted to molecular & cellular mechanisms 28 ( 7 ) 526 - 534 2023.7 （ ISSN:1356-9597 eISSN:1365-2443 ）

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Neuronal regeneration to replenish lost neurons after injury is critical for brain repair. Microglia, brain-resident macrophages that have the propensity to accumulate at the site of injury, can be a potential source for replenishing lost neurons through fate conversion into neurons, induced by forced expression of neuronal lineage-specific transcription factors. However, it has not been strictly demonstrated that microglia, rather than central nervous system-associated macrophages, such as meningeal macrophages, convert into neurons. Here, we show that NeuroD1-transduced microglia can be successfully converted into neurons in vitro using lineage-mapping strategies. We also found that a chemical cocktail treatment further promoted NeuroD1-induced microglia-to-neuron conversion. NeuroD1 with loss-of-function mutation, on the other hand, failed to induce the neuronal conversion. Our results indicate that microglia are indeed reprogrammed into neurons by NeuroD1 with neurogenic transcriptional activity.

DOI： 10.1111/gtc.13033

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[Neuromyelitis Optica Spectrum Disorders].

Kotaro Iida, Noriko Isobe

Brain and nerve = Shinkei kenkyu no shinpo 75 ( 6 ) 705 - 710 2023.6 （ ISSN:18816096 eISSN:13448129 ）

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Neuromyelitis optica spectrum disorders (NMOSD) are inflammatory autoimmune disorders of the central nervous system, that primarily cause optic neuritis and myelitis. Aquaporin-4 (AQP4) antibody is the key in NMOSD pathophysiology, which causes astrocytopathy, demyelination, and neuropathy through complement activation and cell-mediated immunity. Currently, biopharmaceutical agents are introduced for preventing relapse with high efficacy, expected to reduce side effects derived from long-term steroid therapy, and improve patients' quality of life.

DOI： 10.11477/mf.1416202405

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Factors Associated with Glatiramer Acetate Efficacy in Japanese Multiple Sclerosis

Tanaka, E; Watanabe, M; Fukumoto, S; Suezumi, K; Matsushita, T; Isobe, N; Masaki, K

MULTIPLE SCLEROSIS JOURNAL 29 ( 7 ) NP34 - NP35 2023.6 （ ISSN:1352-4585 eISSN:1477-0970 ）

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Astroglial Connexin 43 is a Novel Therapeutic Target for a Chronic Multiple Sclerosis Model

Ozdemir, E; Yamasaki, R; Nagata, S; Watanabe, M; Yamaguchi, H; Masaki, K; Kira, J; Takeuchi, H; Isobe, N

MULTIPLE SCLEROSIS JOURNAL 29 ( 7 ) NP2 - NP2 2023.6 （ ISSN:1352-4585 eISSN:1477-0970 ）

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Demyelinating Neuropathy with Markedly Elevated Serum IgG4 Levels and Anti-Contactin 1 IgG4 Antibody

Fukushima Taiki, Ikeda Shohei, Tomita Minoru, Mori Yu, Fukami Yuki, Koike Haruki, Katsuno Masahisa, Ogata Hidenori, Isobe Noriko, Hattori Naoki

Internal Medicine 62 ( 9 ) 1341 - 1344 2023.5 （ ISSN:09182918 eISSN:13497235 ）

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We herein report a 77-year-old man with a 4-month history of progressive gait and sensory disturbances of the extremities. A nerve conduction study indicated demyelinating polyneuropathy. Serum IgG4 levels and anti-contactin 1 IgG4 antibodies were markedly increased. The sural nerve biopsy specimen showed IgG4-positive plasma cell infiltration in the epineurium. Treatment with steroids resulted in an amelioration of functional status, improvement of nerve conduction parameters, decreased serum IgG4 levels, and negative conversion of anti-contactin 1 antibody. Further studies are needed to clarify the significance of IgG4-positive plasma cell infiltration in anti-contactin 1 antibody-positive neuropathies. 

DOI： 10.2169/internalmedicine.9286-21

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高齢発症の感覚性失調を認めた抗contactin-1抗体陽性ノドパチーの1例

原田しずか, 松原崇一朗, 中原圭一, 緒方英紀, 磯部紀子, 植田光晴

臨床神経学 63 ( 5 ) 335 - 335 2023.5

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血清IgG4濃度と抗コンタクチン1 IgG4抗体の著明な上昇を伴う脱髄性ニューロパチー(Demyelinating Neuropathy with Markedly Elevated Serum IgG4 Levels and Anti-Contactin 1 IgG4 Antibody)

Fukushima Taiki, Ikeda Shohei, Tomita Minoru, Mori Yu, Fukami Yuki, Koike Haruki, Katsuno Masahisa, Ogata Hidenori, Isobe Noriko, Hattori Naoki

Internal Medicine 62 ( 9 ) 1341 - 1344 2023.5 （ ISSN:0918-2918 ）

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症例は77歳男性で、4ヵ月前から進行性の下肢のしびれと歩行障害を認めていた。可溶性インターロイキン2受容体、総IgG、IgG4の血清中濃度が上昇していたが、補体を含む他の項目には明らかな異常は認められなかった。頭部および脊椎MRIと全身CTでも明らかな異常は認められなかった。神経伝導検査の所見は、脱髄性感覚運動型多発ニューロパチーに一致した。腓腹神経生検では、神経上膜にIgG4陽性形質細胞浸潤が認められた。電気生理学的検査の結果から慢性炎症性脱髄性多発神経炎と診断し、免疫グロブリン静注療法(IVIg)を開始した。2コース目のIVIgから効果を認めなかったため、ステロイド治療を行った。治療開始前の血清検査で、抗コンタクチン1抗体の陽性が判明した。治療により症状が改善すると、血清IgG4レベルが低下し、抗コンタクチン1抗体が陰性化した。
Early and extensive alterations of glial connexins, distal oligodendrogliopathy type demyelination, and nodal/paranodal pathology are characteristic of multiple system atrophy. International journal

Yuji Nishimura, Katsuhisa Masaki, Dai Matsuse, Hiroo Yamaguchi, Tatsunori Tanaka, Eriko Matsuo, Shotaro Hayashida, Mitsuru Watanabe, Takuya Matsushita, Shoko Sadashima, Naokazu Sasagasako, Ryo Yamasaki, Noriko Isobe, Toru Iwaki, Jun-Ichi Kira

Brain pathology (Zurich, Switzerland) 33 ( 3 ) e13131 2023.5 （ ISSN:1015-6305 eISSN:1750-3639 ）

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The pathological hallmark of multiple system atrophy (MSA) is aberrant accumulation of phosphorylated α-synuclein in oligodendrocytes, forming glial cytoplasmic inclusions (GCIs). Extensive demyelination occurs particularly in the olivopontocerebellar and striatonigral pathways, but its precise mechanism remains elusive. Glial connexins (Cxs), which form gap junction channels between astrocytes and oligodendrocytes, play critical roles in myelin maintenance, and have not been studied in MSA. Therefore, we immunohistochemically investigated glial Cx changes in the cerebellar afferent fibers in 15 autopsied patients with MSA. We classified demyelinating lesions into three stages based on Klüver-Barrera staining: early (Stage I), intermediate (Stage II), and late (Stage III) stages showing subtle, moderate, and severe myelin reduction, respectively. Myelin-associated glycoprotein, but not myelin oligodendrocyte glycoprotein, was preferentially decreased in Stage I, suggesting distal oligodendrogliopathy type demyelination. Accumulation of phosphorylated α-synuclein in oligodendrocytes was frequently seen in Stage I but less frequently observed in Stages II and III. Tubulin polymerization-promoting protein (TPPP/p25α)-positive oligodendrocytes were preserved in Stage I but successively decreased in Stages II and III. Even at Stage I, Cx32 was nearly absent from myelin, despite the relative preservation of other nodal proteins, such as neurofascin, claudin-11/oligodendrocyte-specific protein, and contactin-associated protein 1, which successively decreased in the later stages. Cx32 was re-distributed in the oligodendrocyte cytoplasm and co-localized with GCIs. Cx47 gradually decreased at the oligodendrocyte surface in a stage-dependent manner but was not co-localized with GCIs. Astrocytic Cx43 was down-regulated in Stage I but up-regulated in Stages II and III, reflecting astrogliosis. Cx43/Cx47 gap junctions significantly decreased from Stage I to III. Activated microglia/macrophages and T cells infiltrated in Stage I rather than Stages II and III. Therefore, early and extensive alterations of glial Cxs, particularly Cx32 loss, occur in MSA and may accelerate distal oligodendrogliopathy type demyelination and nodal/paranodal dysfunction through disruption of inter-glial communication.

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Anti-LGI4 Antibody Is a Novel Juxtaparanodal Autoantibody for Chronic Inflammatory Demyelinating Polyneuropathy. International journal

Xu Zhang, Jun-Ichi Kira, Hidenori Ogata, Tomohiro Imamura, Mikio Mitsuishi, Takayuki Fujii, Masaki Kobayashi, Kazuo Kitagawa, Yukihiro Namihira, Yusuke Ohya, Guzailiayi Maimaitijiang, Ryo Yamasaki, Yuko Fukata, Masaki Fukata, Noriko Isobe, Yuri Nakamura

Neurology(R) neuroimmunology & neuroinflammation 10 ( 2 ) 2023.3 （ ISSN:2332-7812 ）

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BACKGROUND AND OBJECTIVES: The objective of this study was to discover novel nodal autoantibodies in chronic inflammatory demyelinating polyneuropathy (CIDP). METHODS: We screened for autoantibodies that bind to mouse sciatic nerves and dorsal root ganglia (DRG) using indirect immunofluorescence (IFA) assays with sera from 113 patients with CIDP seronegative for anti-neurofascin 155 and anticontactin-1 antibodies and 127 controls. Western blotting, IFA assays using HEK293T cells transfected with relevant antigen expression plasmids, and cell-based RNA interference assays were used to identify target antigens. Krox20 and Periaxin expression, both of which independently control peripheral nerve myelination, was assessed by quantitative real-time PCR after application of patient and control sera to Schwann cells. RESULTS: Sera from 4 patients with CIDP, but not control sera, selectively bound to the nodal regions of sciatic nerves and DRG satellite glia (p = 0.048). The main immunoglobulin G (IgG) subtype was IgG4. IgG from these 4 patients stained a 60-kDa band on Western blots of mouse DRG and sciatic nerve lysates. These features indicated leucine-rich repeat LGI family member 4 (LGI4) as a candidate antigen. A commercial anti-LGI4 antibody and IgG from all 4 seropositive patients with CIDP showed the same immunostaining patterns of DRG and cultured rat Schwann cells and bound to the 60-kDa protein in Western blots of LGI4 overexpression lysates. IgG from 3 seropositive patients, but none from controls, bound to cells cotransfected with plasmids containing LGI4 and a disintegrin and metalloprotease domain-containing protein 22 (ADAM22), an LGI4 receptor. In cultured rat Schwann and human melanoma cells constitutively expressing LGI4, LGI4 siRNA effectively downregulated LGI4 and reduced patients' IgG binding compared with scrambled siRNA. Application of serum from a positive patient to Schwann cells expressing ADAM22 significantly reduced the expression of Krox20, but not Periaxin. Anti-LGI4 antibody-positive patients had a relatively old age at onset (mean age 58 years), motor weakness, deep and superficial sensory impairment with Romberg sign, and extremely high levels of CSF protein. Three patients showed subacute CIDP onset resembling Guillain-Barré syndrome. DISCUSSION: IgG4 anti-LGI4 antibodies are found in some elderly patients with CIDP who present subacute sensory impairment and motor weakness and are worth measuring, particularly in patients with symptoms resembling Guillain-Barré syndrome.

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Polygenic risk score association with multiple sclerosis susceptibility and phenotype in Europeans. International journal

Hengameh Shams, Xiaorong Shao, Adam Santaniello, Gina Kirkish, Adil Harroud, Qin Ma, Noriko Isobe, Catherine Schaefer, Jacob L McCauley, Bruce A C Cree, Alessandro Didonna, Sergio E Baranzini, Nikolaos A Patsopoulos, Stephen L Hauser, Lisa F Barcellos, Roland G Henry, Jorge R Oksenberg

Brain : a journal of neurology 146 ( 2 ) 645 - 656 2023.2 （ ISSN:0006-8950 eISSN:1460-2156 ）

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Polygenic inheritance plays a pivotal role in driving multiple sclerosis susceptibility, an inflammatory demyelinating disease of the central nervous system. We developed polygenic risk scores (PRS) of multiple sclerosis and assessed associations with both disease status and severity in cohorts of European descent. The largest genome-wide association dataset for multiple sclerosis to date (n = 41,505) was leveraged to generate PRS scores, serving as an informative susceptibility marker, tested in two independent datasets, UK Biobank [UKBB, area under the curve (AUC) = 0.73, 95% CI: 0.72-0.74, P = 6.41e-146] and Kaiser Permanente in Northern California (KPNC, AUC = 0.8, 95% CI: 0.76-0.82, P = 1.5e-53). Individuals within the top 10% of PRS were at greater than five-fold increased risk in UK Biobank (95% CI: 4.7-6, P = 2.8e-45) and fifteen-fold higher risk in KPNC (95% CI: 10.4-24, P = 3.7e-11), relative to the median decile. The cumulative absolute risk of developing multiple sclerosis from age 20 onwards was significantly higher in genetically predisposed individuals according to PRS. Furthermore, inclusion of PRS increased the risk discrimination by 13% to 26% over models based only on conventional multiple sclerosis risk factors, such as smoking and mononucleosis infection, in UKBB and KPNC, respectively. Stratifying disease risk by gene sets representative of curated cellular signaling cascades, nominated promising genetic candidate programs for functional characterization. These pathways include inflammatory signaling mediation, response to viral infection, oxidative damage, RNA polymerase transcription, and epigenetic regulation of gene expression to be among significant contributors to multiple sclerosis susceptibility. This study also indicates that PRS is a useful measure for estimating susceptibility within related individuals in multi-case families. We show a significant association of genetic predisposition with thalamic atrophy within 10 years of disease progression in the UCSF-EPIC cohort (P < 0.001), consistent with a partial overlap between the genetics of susceptibility and end-organ tissue injury. Mendelian randomization analysis suggested an effect of multiple sclerosis susceptibility on thalamic volume, which was further indicated to be through horizontal pleiotropy rather than a causal effect. In summary, this study indicates important, replicable associations of PRS with enhanced risk assessment and radiographic outcomes of tissue injury, potentially informing targeted screening and prevention strategies.

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Effect of smoking on disease activity in multiple sclerosis patients treated with dimethyl fumarate or fingolimod. International journal

Eizo Tanaka, Mitsuru Watanabe, Shoko Fukumoto, Katsuhisa Masaki, Ryo Yamasaki, Takuya Matsushita, Noriko Isobe

Multiple sclerosis and related disorders 70 104513 - 104513 2023.2 （ ISSN:2211-0348 eISSN:2211-0356 ）

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BACKGROUND: In relapsing-remitting multiple sclerosis (RRMS), smoking is a known risk factor for disease susceptibility and disability progression. However, its impact on the efficacy of oral disease-modifying drugs (DMDs) is unclear. Therefore, we initiated a single-center, retrospective, observational study to investigate the relationship between smoking and disease activity in RRMS patients under oral DMDs. METHODS: We retrospectively enrolled RRMS patients who initiated oral DMDs (fingolimod or dimethyl fumarate) at our hospital between January 2012 and December 2019. Clinical data and smoking status at oral DMD initiation were collected up to December 2020. We conducted survival analyses for relapse and any disease activity, defined as relapse or MRI disease activity, among patients with distinct smoking statuses. RESULTS: We enrolled 103 RRMS patients under oral DMDs including 19 (18.4%) current smokers at baseline. Proportions of relapses and any disease activity during follow-up were higher in current smokers (relapse: p = 0.040, any disease activity: p = 0.004) and time from initiating oral DMDs to relapse was shorter in current smokers (log-rank test: p = 0.011; Cox proportional hazard analysis: hazard ratio (HR) 2.72 [95% confidence interval (CI) 1.22-6.09], p = 0.015) than in non-smokers. Time from initiating oral DMDs to any disease activity was also shorter in current smokers (log-rank test: p = 0.016; Cox proportional hazard analysis: HR 2.18 [95% CI 1.14-4.19], p = 0.019) than in non-smokers. The survival curves for relapse and any disease activity were not different between the former smoker and never-smoker groups. Multivariate survival analysis showed current smoking was an independent risk factor for relapse or any disease activity after adjusting for covariates (relapse: HR 2.54 [95% CI 1.06-6.10], p = 0.037; any disease activity: HR 3.47 [95% CI 1.27-9.50], p = 0.015). CONCLUSION: Smoking was a risk factor for disease activity in RRMS patients under oral DMD treatment. RRMS patients should be advised to stop smoking even after the initiation of DMDs.

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難病研究会　神経筋疾患を対象とした臨床試験における患者報告アウトカムの利用　患者中心の臨床試験を目指して

小早川優子, 磯部紀子

難病と在宅ケア 28 ( 10 ) 45 - 48 2023.1 （ ISSN:1880-9200 ）

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神経筋疾患を対象とした臨床試験における患者報告アウトカム(Patient-Reported Outcome:PRO)の利用状況を明らかにすることを目的に、グローバルな臨床試験登録データベースであるClinicalTrials.govを用いて、筋萎縮性側索硬化症など神経筋疾患の中でも運動機能障害をきたす代表的な9疾患を対象に検索を行い、評価項目にPROを含む臨床試験(PRO関連臨床試験)の割合について、疾患および期間別に比較した。その結果、最もPRO関連臨床試験数の割合が高い疾患は重症筋無力症で、2017～2021年に開始された臨床試験の約8割で評価項目にPROが使用されていた。一方、PRO関連臨床試験の割合が低い疾患は、筋ジストロフィーおよびハンチントン病で、2017～2021年に開始された臨床試験におけるPRO使用の割合は、いずれも3割以下であった。また、筋萎縮性側索硬化症に対するPRO関連臨床試験について、期間別に検討した結果、2007年～2011年の5年間に比べ2017～2021年の5年間では、PRO関連臨床試験は1.7倍に増加しており、前者の期間ではほとんどの臨床試験で包括的(疾患特異的ではない)PRO尺度が使用されていたが、2012年以降に開始された臨床試験では、約7割で疾患特異的PRO尺度が使用されていることが分かった。
染色体に組み込まれたヒトヘルペスウイルス6を伴う抗NMDA受容体脳炎の症例報告(A case report of anti-N-methyl-D-aspartate receptor encephalitis with chromosomally integrated human herpesvirus 6)

Iwao Kazunori, Watanabe Mitsuru, Mukaino Takahiko, Fujii Takayuki, Yamasaki Ryo, Isobe Noriko

Neurology and Clinical Neuroscience 11 ( 1 ) 52 - 54 2023.1

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脳脊髄液(CSF)で抗NMDA受容体(NMDAR)抗体とヒトヘルペスウイルス6(HHV6)-DNA陽性を示し、抗NMDAR脳炎および染色体に組み込まれたHHV6(ciHHV6)と最終診断された1例について報告した。症例は30歳女性で、Day0に亜急性の情動不安と錯乱状態を呈し頭痛を伴い、Day39に自宅の二階から飛び降りた。救急搬送されたが妄想が認められたため精神病院に移送され、移送先の医療施設で自己免疫性脳炎が疑われたことから、Day67に見当識障害、幻視、被害妄想、妄想気分、情緒不安定、激越を伴った状態で当院に移送された。CSFには軽度の髄液細胞増加、高タンパク血症、抗NMDAR抗体が検出され、血清とCSFからはHHV6-DNA陽性が示されたが、他のヘルペスウイルスDNAは陰性であった。脳波では突発活動を伴わないdiffuse background slowingが検出され、脳MRI検査では正常所見であったが、HHV6脳炎と抗NMDAR脳炎を疑い、抗ウイルス薬投与とメチルプレドニゾロン静注後に、静注免疫グロブリンが投与された。Day82に左卵巣腫瘍に対し腹腔鏡下卵巣摘出術を行い、血漿交換を行ったところ症状は改善され、CSF中細胞数とタンパク質も正常値に低下し、脳波も正常化した。しかし、6週間のガンシクロビル投与後も血清/CSFともにHHV6-DNA陽性、口腔粘膜細胞もHHV6-DNA陽性で、ガンシクロビル投与を中止したが、症状の増悪はみられなかった。以上の所見から、本例は抗NMDAR脳炎とciHHV6と最終診断された。
多発性硬化症（MS）の最新治療戦略　司会の言葉

磯部紀子

神経治療学 40 ( 3 ) 302 - 302 2023 （ ISSN:09168443 eISSN:21897824 ）

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DOI： 10.15082/jsnt.40.3_302

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Connexin 30 Deficiency Ameliorates Disease Progression at the Early Phase in a Mouse Model of Amyotrophic Lateral Sclerosis by Suppressing Glial Inflammation. International journal

Yu Hashimoto, Ryo Yamasaki, Senri Ko, Eriko Matsuo, Yuko Kobayakawa, Katsuhisa Masaki, Dai Matsuse, Noriko Isobe

International journal of molecular sciences 23 ( 24 ) 2022.12 （ ISSN:16616596 eISSN:1422-0067 ）

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Connexin 30 (Cx30), which forms gap junctions between astrocytes, regulates cell adhesion and migration, and modulates glutamate transport. Cx30 is upregulated on activated astroglia in central nervous system inflammatory lesions, including spinal cord lesions in mutant superoxide dismutase 1 (mSOD1) transgenic amyotrophic lateral sclerosis (ALS) model mice. Here, we investigated the role of Cx30 in mSOD1 mice. Cx30 was highly expressed in the pre-onset stage in mSOD1 mice. mSOD1 mice with knockout (KO) of the Cx30 gene (Cx30KO-mSOD1 mice) showed delayed disease onset and tended to have an extended survival period (log-rank, p = 0.09). At the progressive and end stages of the disease, anterior horn cells were significantly preserved in Cx30KO-mSOD1 mice. In lesions of these mice, glial fibrillary acidic protein/C3-positive inflammatory astroglia were decreased. Additionally, the activation of astrocytes in Cx30KO-mSOD1 mice was reduced compared with mSOD1 mice by gene expression microarray. Furthermore, expression of connexin 43 at the pre-onset stage was downregulated in Cx30KO-mSOD1 mice. These findings suggest that reduced expression of astroglial Cx30 at the early disease stage in ALS model mice protects neurons by attenuating astroglial inflammation.

DOI： 10.3390/ijms232416046

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A novel quantitative indicator for disease progression rate in amyotrophic lateral sclerosis. International journal

Yuko Kobayakawa, Koji Todaka, Yu Hashimoto, Senri Ko, Wataru Shiraishi, Junji Kishimoto, Jun-Ichi Kira, Ryo Yamasaki, Noriko Isobe

Journal of the neurological sciences 442 120389 - 120389 2022.11 （ ISSN:0022-510X eISSN:1878-5883 ）

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OBJECTIVE: The current study sought to develop a new indicator for disease progression rate in amyotrophic lateral sclerosis (ALS). METHODS: We used a nonparametric method to score diverse patterns of decline in the percentage of predicted forced vital capacity (%FVC) in patients with ALS. This involved 6317 longitudinal %FVC data sets from 920 patients in the Pooled Resource Open-Access ALS Clinical Trials (PRO-ACT) database volunteered by PRO-ACT Consortium members. To assess the utility of the derived scores as a disease indicator, we examined changes over time, the association with prognosis, and correlation with the Risk Profile of the Treatment Research Initiative to Cure ALS (TRICALS). Our local cohort (n = 92) was used for external validation. RESULTS: We derived scores ranging from 35 to 106 points to construct the FVC Decline Pattern scale (FVC-DiP). Individuals' FVC-DiP scores were determined from a single measurement of %FVC and disease duration at assessment. Although the %FVC declined over the disease course (p < 0.0001), the FVC-DiP remained relatively stable. Low FVC-DiP scores were associated with rapid disease progression. Using our cohort, we demonstrated an association between FVC-DiP and the survival prognosis, the stability of the FVC-DiP per individual, and a correlation between FVC-DiP scores and the TRICALS Risk Profile (r2 = 0.904, p < 0.0001). CONCLUSIONS: FVC-DiP scores reflected patterns of declining %FVC over the natural course of ALS and indicated the disease progression rate. The FVC-DiP may enable easy assessment of disease progression patterns and could be used for assessing treatment efficacy.

DOI： 10.1016/j.jns.2022.120389

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The effect of interictal epileptic discharges and following spindles on motor sequence learning in epilepsy patients. International journal

Toshiki Okadome, Takahiro Yamaguchi, Takahiko Mukaino, Ayumi Sakata, Katsuya Ogata, Hiroshi Shigeto, Noriko Isobe, Taira Uehara

Frontiers in neurology 13 979333 - 979333 2022.11 （ ISSN:1664-2295 ）

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PURPOSE: Interictal epileptic discharges (IEDs) are known to affect cognitive function in patients with epilepsy, but the mechanism has not been elucidated. Sleep spindles appearing in synchronization with IEDs were recently demonstrated to impair memory consolidation in rat, but this has not been investigated in humans. On the other hand, the increase of sleep spindles at night after learning is positively correlated with amplified learning effects during sleep for motor sequence learning. In this study, we examined the effects of IEDs and IED-coupled spindles on motor sequence learning in patients with epilepsy, and clarified their pathological significance. MATERIALS AND METHODS: Patients undergoing long-term video-electroencephalography (LT-VEEG) at our hospital from June 2019 to November 2021 and age-matched healthy subjects were recruited. Motor sequence learning consisting of a finger-tapping task was performed before bedtime and the next morning, and the improvement rate of performance was defined as the sleep-dependent learning effect. We searched for factors associated with the changes in learning effect observed between the periods of when antiseizure medications (ASMs) were withdrawn for LT-VEEG and when they were returned to usual doses after LT-VEEG. RESULTS: Excluding six patients who had epileptic seizures at night after learning, nine patients and 11 healthy subjects were included in the study. In the patient group, there was no significant learning effect when ASMs were withdrawn. The changes in learning effect of the patient group during ASM withdrawal were not correlated with changes in sleep duration or IED density; however, they were significantly negatively correlated with changes in IED-coupled spindle density. CONCLUSION: We found that the increase of IED-coupled spindles correlated with the decrease of sleep-dependent learning effects of procedural memory. Pathological IED-coupled sleep spindles could hinder memory consolidation, that is dependent on physiological sleep spindles, resulting in cognitive dysfunction in patients with epilepsy.

DOI： 10.3389/fneur.2022.979333

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難病診療連携コーディネーターの配置状況と業務実態 5年前の調査と比較した近年の傾向と問題点

松瀬大, 原田幸子, 岩木三保, 齋藤聖子, 深川知栄, 橋本侑, 磯部紀子

日本難病医療ネットワーク学会機関誌 10 ( 1 ) 61 - 61 2022.11

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Cerebral Tuberculoma with Mild Posterior Cervical Pain as the Main Symptom Despite Extensive Brain Lesions

Saitoh Ban-yu, Tateishi Takahisa, Yoshimura Motoi, Suzuki Satoshi O., Isobe Noriko, Iwaki Toru, Kira Jun-ichi

Internal Medicine 61 ( 19 ) 2941 - 2945 2022.10 （ ISSN:09182918 eISSN:13497235 ）

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A 59-year-old woman with a diabetes history experienced mild neck pain. A neurological examination revealed only mild neck stiffness. Magnetic resonance imaging showed extensive T2-weighted high-intensity lesions with patchy gadolinium enhancement mainly involving the white matter in the right parietal lobe. A cerebrospinal fluid analysis revealed increased protein levels and pleocytosis. While QuantiFERON-TB Gold was positive, computed tomography (CT) and fluorodeoxyglucose on positron emission tomography-CT of the whole body showed no abnormal accumulation, suggesting tuberculosis. A brain biopsy revealed cerebral tuberculoma. As cerebral tuberculoma can show minimal neurological symptoms despite extensive lesions, a cautious examination and early treatment are required to prevent a devastating prognosis. 

DOI： 10.2169/internalmedicine.9020-21

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筋萎縮性側索硬化症モデルマウスにおけるコネキシン30の発現調節異常の役割(The role of dysregulated connexin 30 expression in amyotrophic lateral sclerosis model mice)

臨床神経学 62 ( Suppl. ) S377 - S377 2022.10

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一過性脳虚血発作様の発作を繰り返した神経核内封入体病の1例

倉沢亮, 渡邉充, 向野隆彦, 入江剛史, 山崎亮, 磯部紀子

臨床神経学 62 ( 10 ) 815 - 815 2022.10

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突発性のてんかん性放電とは異なるてんかん性脳波異常を機械学習にて検出する試み

山口高弘, 岡留敏樹, 向野隆彦, 上原平, 下川能史, 重藤寛史, 磯部紀子

臨床神経生理学 50 ( 5 ) 403 - 403 2022.10

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感覚性運動失調,振戦,左外転神経麻痺を呈し,経頭蓋磁気刺激で中枢伝導時間延長を認めた抗NF155抗体陽性CIDPの1例

松本正太, 清水崇宏, 種田建太, 守安正太郎, 渡辺保裕, 瀧川洋史, 緒方英紀, 磯部紀子, 花島律子

臨床神経学 62 ( 10 ) 823 - 823 2022.10

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広範な脳病変にもかかわらず軽度の後頸部痛を主症状として認めた脳結核腫(Cerebral Tuberculoma with Mild Posterior Cervical Pain as the Main Symptom Despite Extensive Brain Lesions)

Saitoh Ban-yu, Tateishi Takahisa, Yoshimura Motoi, Suzuki Satoshi O., Isobe Noriko, Iwaki Toru, Kira Jun-ichi

Internal Medicine 61 ( 19 ) 2941 - 2945 2022.10 （ ISSN:0918-2918 ）

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症例は59歳女性。糖尿病と脳梗塞の既往を有し、軽度の後頸部痛を認めた。神経学的検査では、軽度の頸部硬直のみを認めた。ツベルクリン反応が軽度陽性で、QuantiFERON-TBゴールドで検査したMycobacterium tuberculosisインターフェロンγが強陽性であった。脳脊髄液検査で、髄液細胞増加とタンパクレベルおよびIgG指数の上昇が判明した。MRI検査では、右頭頂葉の皮質下白質に斑状のガドリニウム造影を認める広範なT2強調高信号病変が明らかとなった。全身のCT検査およびFDG-PET/CTでは、明らかな結核病変を認めなかった。確定診断のために脳生検を行い、脳結核腫を確認した。イソニアジド、リファンピシン、ピラジナミド、エタンブトール、デキサメタゾンの投与を行ったが、薬剤性皮疹が出現したために中止した。次に、ストレプトマイシン、エタンブトール、レボフロキサシンの投与を行ったが、別の皮疹が出現したために中断した。ストレプトマイシン、イソニアジド、リファンピシンの漸増による化学療法を開始したところ、4ヵ月後に頸部硬直が消失した。
Synucleionopathy-Associated Microglia Uncovered by a Novel Multiple System Atrophy-Cerebellar Type (MSA-c) Mouse Model

Kira, J; Yamaguchi, H; Nishimura, Y; Matsuse, D; Masaki, K; Yamasaki, R; Isobe, N

ANNALS OF NEUROLOGY 92 S125 - S126 2022.10 （ ISSN:0364-5134 eISSN:1531-8249 ）

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Atrophy of the hippocampal CA1 subfield relates to long-term forgetting in focal epilepsy. International journal

Takahiko Mukaino, Taira Uehara, Jun Yokohama, Toshiki Okadome, Tomomi Arakawa, Setsu Yokoyama, Ayumi Sakata, Kei-Ichiro Takase, Osamu Togao, Naoki Akamatsu, Hiroshi Shigeto, Noriko Isobe, Jun-Ichi Kira

Epilepsia 63 ( 10 ) 2623 - 2636 2022.10 （ ISSN:0013-9580 eISSN:1528-1167 ）

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OBJECTIVE: The mechanisms underlying accelerated long-term forgetting (ALF) in patients with epilepsy are still under investigation. We examined the contribution of hippocampal subfields and their morphology to long-term memory performance in patients with focal epilepsy. METHODS: We prospectively assessed long-term memory and performed magnetic resonance imaging in 80 patients with focal epilepsy (61 with temporal lobe epilepsy and 19 with extratemporal lobe epilepsy) and 30 healthy controls. The patients also underwent electroencephalography recording. Verbal and visuospatial memory was tested 30 s, 10 min, and 1 week after learning. We assessed the volumes of the whole hippocampus and seven subfields and deformation of the hippocampal shape. The contributions of the hippocampal volumes and shape deformation to long-term forgetting, controlling for confounding factors, including the presence of interictal epileptiform discharges, were assessed by multiple regression analyses. RESULTS: Patients with focal epilepsy had lower intelligence quotients and route recall scores at 10 min than controls. The focal epilepsy group had smaller volumes of both the right and left hippocampal tails than the control group, but there were no statistically significant group differences for the volumes of the whole hippocampus or other hippocampal subfields. Multiple regression analyses showed a significant association between the left CA1 volume and the 1-week story retention (β = 7.76; Bonferroni-corrected p = 0.044), but this was not found for the whole hippocampus or other subfield volumes. Hippocampal shape analyses revealed that atrophy of the superior-lateral, superior-central, and inferior-medial regions of the left hippocampus, corresponding to CA1 and CA2/3, was associated with the verbal retention rate. SIGNIFICANCE: Our results suggest that atrophy of the hippocampal CA1 region and its associated structures disrupts long-term memory consolidation in focal epilepsy. Neuronal cell loss in specific hippocampal subfields could be a key underlying cause of ALF in patients with epilepsy.

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Teaching Video NeuroImage: Reversible Parkinsonism Caused by Lumboperitoneal Shunt Overdrainage. International journal

Hajime Takeuchi, Katsuhisa Masaki, Hidenori Ogata, Satoshi Nagata, Takafumi Shimogawa, Ryo Yamasaki, Noriko Isobe

Neurology 99 ( 11 ) 486 - 488 2022.9 （ ISSN:0028-3878 eISSN:1526-632X ）

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DOI： 10.1212/WNL.0000000000200994

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Two-step nationwide epidemiological survey of myasthenia gravis in Japan 2018

Yoshikawa H., Adachi Y., Nakamura Y., Kuriyama N., Murai H., Nomura Y., Sakai Y., Iwasa K., Furukawa Y., Kuwabara S., Matsui M., Izumi Y., Isobe N., Akiyuki U., Ogino M., Kaida K., Kawachi I., Koike H., Satou Y., Shimizu Y., Sonoo M., Takeuchi H., Tawara M., Nakajima I., Nakatsuji Y., Nakanishi E., Nakahara J., Niino M., Fujiwara K., Misawa S., Motomura M., Yamamura T., Yokota T.

PLoS ONE 17 ( 9 September ) 2022.9

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Objective To study the updated prevalence and clinical features of myasthenia gravis (MG) in Japan during 2017. Methods We sent survey sheets to the randomly selected medical departments (number = 7,545). First, we asked the number of MG patients who visited medical departments from January 1, 2017, to December 31, 2017. Then, we sent the second survey sheet to the medical departments that answered the first survey to obtain the clinical information of patients who received MG diagnosis between January 1, 2015, and December 31, 2017. Results The received answer to the first survey were 2,708 (recovery rate: 35.9%). After all, the prevalence of the 100,000 population was estimated as 23.1 (95%CI: 20.5-25.6). As a result of the second survey, we obtained 1,464 case records. After checking the duplications and lacking data, we utilized 1,195 data for further analysis. The median [interquartile range (IQR)] from the onset age of total patients was 59 (43-70) years old. The male-female ratio was 1: 1.15. The onset age [median (IQR)] for female patients was 58 (40-72) years old, and that for male patients was 60 (49-69) years old (Wilcoxon-Mann-Whitney test, p = 0.0299). We divided patients into four categories: 1) anti-acetylcholine receptor antibody (AChRAb) (+) thymoma (Tm) (-), 2) AChRAb(+)Tm(+), 3) anti-muscle-specific kinase antibody (MuSKAb) (+), and AChRAb(-)MuSKAb(-) (double negative; DN). The onset age [median (IQR)] of AChRAb(+)Tm(-) was 64 (48-73) years old, and AChRb(+)Tm(+) was 55 (45-66), MuSKAb(+) was 49 (36-64), DN was 47 (35-60) year old. The multivariate logistic regression analysis using sex, initial symptoms, repetitive nerve stimulation test (RNST), and edrophonium test revealed that sex, ocular symptoms, bulbar symptoms, and RNST were factors to distinguish each category. The myasthenia gravis activities of daily living profile at the severest state were significantly higher in MuSKAb(+). MuSKAb(+) frequently received prednisolone, tacrolimus plasmapheresis, and intravenous immunoglobulin; however, they received less acetylcholine esterase inhibitor. 99.2% of AChRAb(+)Tm(+) and 15.4% of AChRAb(+)Tm(-) received thymectomy. MuSKAb(+) did not receive thymectomy, and only 5.7% of DN received thymectomy. The prognosis was favorable in all categories. Conclusion Our result revealed that the prevalence of Japanese MG doubled from the previous study using the same survey method in 2006. We also found that the onset age shifted to the elderly, and the male-female ratio reached almost even. Classification in four categories; AChRAb(+)Tm(-), AChRAb(+)Tm(+), MuSKAb(+), and DN, well describe the specific clinical features of each category and differences in therapeutic approaches.

DOI： 10.1371/journal.pone.0274161

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VIII. Multiple Sclerosis

Isobe Noriko

Nihon Naika Gakkai Zasshi 111 ( 8 ) 1555 - 1559 2022.8 （ ISSN:00215384 eISSN:18832083 ）

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DOI： 10.2169/naika.111.1555

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海馬回旋異常における構造的MRIの特徴の検討

向野隆彦, 山口高弘, 岡留敏樹, 山田絵美, 太田真理, 三笘良, 光藤崇子, 田村俊介, 平野羊嗣, 栂尾理, 萩原綱一, 磯部紀子, 重藤寛史

てんかん研究 40 ( 2 ) 440 - 440 2022.8

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慢性硬膜下電極記録に対し畳み込みニューラルネットワークを用いて行ったてんかん原性領域の自動推定

岡留敏樹, 山口高弘, 向野隆彦, 渡邊恵利子, 酒田あゆみ, 下川能史, 迎伸孝, 森岡隆人, 磯部紀子, 重藤寛史

てんかん研究 40 ( 2 ) 411 - 411 2022.8

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海馬回旋異常における構造的MRIの特徴の検討

向野隆彦, 山口高弘, 岡留敏樹, 山田絵美, 太田真理, 三笘良, 光藤崇子, 田村俊介, 平野羊嗣, 栂尾理, 萩原綱一, 磯部紀子, 重藤寛史

てんかん研究 40 ( 2 ) 440 - 440 2022.8

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Internal Carotid Artery Tortuosity: Impact on Mechanical Thrombectomy. International journal

Junpei Koge, Kanta Tanaka, Takeshi Yoshimoto, Masayuki Shiozawa, Yuji Kushi, Tsuyoshi Ohta, Tetsu Satow, Hiroharu Kataoka, Masafumi Ihara, Masatoshi Koga, Noriko Isobe, Kazunori Toyoda

Stroke 53 ( 8 ) 2458 - 2467 2022.8 （ ISSN:0039-2499 eISSN:1524-4628 ）

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BACKGROUND: Although tortuosity of the internal carotid artery (ICA) can pose a significant challenge when performing mechanical thrombectomy, few studies have examined the impact of ICA tortuosity on mechanical thrombectomy outcomes. METHODS: In a registry-based hospital cohort, consecutive patients with anterior circulation stroke in whom mechanical thrombectomy was attempted were divided into 2 groups: those with tortuosity in the extracranial or cavernous ICA (tortuous group) and those without (nontortuous group). The extracranial ICA tortuosity was defined as the presence of coiling or kinking. The cavernous ICA tortuosity was defined by the posterior deflection of the posterior genu or the shape resembling Simmons-type catheter. Outcomes included first pass effect (FPE; extended Thrombolysis in Cerebral Infarction score 2c/3 after first pass), favorable outcome (3-month modified Rankin Scale score of 0-2), and intracranial hemorrhage. RESULTS: Of 370 patients, 124 were in the tortuous group (extracranial ICA tortuosity, 35; cavernous ICA tortuosity, 70; tortuosity at both sites, 19). The tortuous group showed a higher proportion of women and atrial fibrillation than the nontortuous group. FPE was less frequently achieved in the tortuous group than the nontortuous group (21% versus 39%; adjusted odds ratio, 0.45 [95% CI, 0.26-0.77]). ICA tortuosity was independently associated with the longer time from puncture to extended Thrombolysis in Cerebral Infarction ≥2b reperfusion (β=23.19 [95% CI, 13.44-32.94]). Favorable outcome was similar between groups (46% versus 48%; P=0.87). Frequencies of any intracranial hemorrhage (54% versus 42%; adjusted odds ratio, 1.61 [95% CI, 1.02-2.53]) and parenchymal hematoma (11% versus 6%; adjusted odds ratio, 2.41 [95% CI, 1.04-5.58]) were higher in the tortuous group. In the tortuous group, the FPE rate was similar in patients who underwent combined stent retriever and contact aspiration thrombectomy and in those who underwent either procedure alone (22% versus 19%; P=0.80). However, in the nontortuous group, the FPE rate was significantly higher in patients who underwent combined stent retriever and contact aspiration (52% versus 35%; P=0.02). CONCLUSIONS: ICA tortuosity was independently associated with reduced likelihood of FPE and increased risk of postmechanical thrombectomy intracranial hemorrhage. REGISTRATION: URL: https://www. CLINICALTRIALS: gov; Unique identifier: NCT02251665.

DOI： 10.1161/STROKEAHA.121.037904

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小脳磁気刺激検査で異常を認めた抗NF155抗体関連ニューロパチーの1例

種田建太, 清水崇宏, 守安正太郎, 緒方英紀, 磯部紀子, 宇川義一, 花島律子

パーキンソン病・運動障害疾患コングレスプログラム・抄録集 16回 100 - 100 2022.7

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Preparation of Various Nanomaterials via Controlled Gelation of a Hydrophilic Polymer Bearing Metal-Coordination Units with Metal Ions

Nagai, D; Isobe, N; Inoue, T; Okamoto, S; Maki, Y; Yamanobe, T

GELS 8 ( 7 ) 2022.7 （ eISSN:2310-2861 ）

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DOI： 10.3390/gels8070435

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DEVELOPMENT OF STANDARDIZED ELISA KITS FOR IGG4 ANTI-NEUROFASCIN 155 AND ANTI-CONTACTIN-1 ANTIBODIES

Ogata, H; Kobayakawa, Y; Amina, A; Yamasaki, R; Kawasaki, A; Takeuchi, C; Kira, J; Isobe, N

JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM 27 S172 - S172 2022.7 （ ISSN:1085-9489 eISSN:1529-8027 ）

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Choroid Plexus Volume in Multiple Sclerosis vs Neuromyelitis Optica Spectrum Disorder: A Retrospective, Cross-sectional Analysis. International journal

Jannis Müller, Tim Sinnecker, Maria Janina Wendebourg, Regina Schläger, Jens Kuhle, Sabine Schädelin, Pascal Benkert, Tobias Derfuss, Philippe Cattin, Christoph Jud, Florian Spiess, Michael Amann, Therese Lincke, Muhamed Barakovic, Alessandro Cagol, Charidimos Tsagkas, Katrin Parmar, Anne-Katrin Pröbstel, Sophia Reimann, Susanna Asseyer, Ankelien Duchow, Alexander Brandt, Klemens Ruprecht, Nouchine Hadjikhani, Shoko Fukumoto, Mitsuru Watanabe, Katsuhisa Masaki, Takuya Matsushita, Noriko Isobe, Jun-Ichi Kira, Ludwig Kappos, Jens Würfel, Cristina Granziera, Friedemann Paul, Özgür Yaldizli

Neurology(R) neuroimmunology & neuroinflammation 9 ( 3 ) 2022.5 （ ISSN:2332-7812 ）

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BACKGROUND AND OBJECTIVES: The choroid plexus has been shown to play a crucial role in CNS inflammation. Previous studies found larger choroid plexus in multiple sclerosis (MS) compared with healthy controls. However, it is not clear whether the choroid plexus is similarly involved in MS and in neuromyelitis optica spectrum disorder (NMOSD). Thus, the aim of this study was to compare the choroid plexus volume in MS and NMOSD. METHODS: In this retrospective, cross-sectional study, patients were included by convenience sampling from 4 international MS centers. The choroid plexus of the lateral ventricles was segmented fully automatically on T1-weighted MRI sequences using a deep learning algorithm (Multi-Dimensional Gated Recurrent Units). Uni- and multivariable linear models were applied to investigate associations between the choroid plexus volume, clinically meaningful disease characteristics, and MRI parameters. RESULTS: We studied 180 patients with MS and 98 patients with NMOSD. In total, 94 healthy individuals and 47 patients with migraine served as controls. The choroid plexus volume was larger in MS (median 1,690 µL, interquartile range [IQR] 648 µL) than in NMOSD (median 1,403 µL, IQR 510 µL), healthy individuals (median 1,533 µL, IQR 570 µL), and patients with migraine (median 1,404 µL, IQR 524 µL; all p < 0.001), whereas there was no difference between NMOSD, migraine, and healthy controls. This was also true when adjusted for age, sex, and the intracranial volume. In contrast to NMOSD, the choroid plexus volume in MS was associated with the number of T2-weighted lesions in a linear model adjusted for age, sex, total intracranial volume, disease duration, relapses in the year before MRI, disease course, Expanded Disability Status Scale score, disease-modifying treatment, and treatment duration (beta 4.4; 95% CI 0.78-8.1; p = 0.018). DISCUSSION: This study supports an involvement of the choroid plexus in MS in contrast to NMOSD and provides clues to better understand the respective pathogenesis.

DOI： 10.1212/NXI.0000000000001147

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Barriers to International Telemedicine Conferencing: A Survey of the National University Hospital Council of Japan

Kudo, K; Isobe, N; Ueda, S; Tomimatsu, S; Moriyama, T; Shimizu, S

TELEMEDICINE AND E-HEALTH 28 ( 3 ) 433 - 439 2022.3 （ ISSN:1530-5627 eISSN:1556-3669 ）

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Introduction: Telemedicine conferencing is expected to become commonly used internationally. However, national reports on internationally related telemedicine are limited, and related activities and challenges in each country are unclear. In this study, we aimed to clarify the current status and barriers to international telemedicine conferencing in Japan. Methods: The questionnaire was sent to the Internationalization Project Team (I-PT) representatives in all 43 Japanese National University Hospitals. The total of 167 assigned staff comprised 86 medical staff in charge of internationalization (MI) and 81 technical staff in telemedicine (TT). Results: The response rate was 93% (40/43 universities) from 88 staff (44 MI and 44 TT). Most respondents (75%) stated that they had not been active in international telemedicine conferencing during the past 3 years, although a videoconferencing system was installed in 93% of universities. A total of 65% respondents felt that barriers to promoting telemedicine and conferencing existed. Most (43%) respondents reported staff shortage as the most serious barrier overall. Five TT (19%) felt that the most serious barrier was difficulty with English communication, although no MI selected this as a barrier. More MI than TT felt that technical issues were the most serious barrier (MI: 4/29, TT: 1/27). Conclusions: International telemedicine conferencing was found to be insufficiently active in I-PT of Japan, although the installed equipment and technical expertise of TT seemed adequate. This indicates that merely assigning MI and TT to an I-PT is not enough and that improved cooperation between both MI and TT at each university hospital is needed. Establishment of a structured international telemedicine center in each university hospital is to be suggested to accelerate the activities in Japan.

DOI： 10.1089/tmj.2021.0046

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【多発性硬化症診療の最新エビデンスと課題】多発性硬化症の疫学データ世界と比較した本邦の特徴

林史恵, 磯部紀子

医学と薬学 79 ( 4 ) 451 - 454 2022.3

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重症筋無力症による眼瞼下垂に対して複数回の眼瞼下垂手術が行われた1例

小出遼平, 田邉美香, 磯部紀子, 園田康平

眼科臨床紀要 15 ( 2 ) 150 - 150 2022.2

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Facial onset sensory and motor neuronopathy(FOSMN)の全国臨床疫学調査結果

江千里, 山崎亮, 奥井佑, 白石渉, 渡邉充, 橋本侑, 小早川優子, 楠進, 吉良潤一, 磯部紀子

日本内科学会雑誌 111 ( Suppl. ) 206 - 206 2022.2

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SEMA3E-Plexin D1経路に着目した筋萎縮側索硬化症の病態解明

藤井敬之, 本田裕之, 山崎亮, 吉村基, 岩城徹, 磯部紀子

日本内科学会雑誌 111 ( Suppl. ) 208 - 208 2022.2

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【2022年医療展望】多発性硬化症早期治療の重要性とCOVID-19流行期における治療のポイント

磯部紀子

クリニシアン 69 ( 1 ) 37 - 40 2022.1

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多発性硬化症において期待される新たな治療戦略

磯部紀子

神経治療学 39 ( 3 ) 273 - 273 2022 （ ISSN:09168443 eISSN:21897824 ）

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DOI： 10.15082/jsnt.39.3_273

CiNii Research
Shadowboxing-induced reflex seizures in a patient with focal epilepsy. International journal

Toshiki Okadome, Hajime Takeuchi, Takahiro Yamaguchi, Takahiko Mukaino, Hidenori Ogata, Katsuhisa Masaki, Hiroshi Shigeto, Noriko Isobe

Epilepsy & behavior reports 19 100543 - 100543 2022 （ eISSN:2589-9864 ）

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Exercise-induced reflex seizures are a rare form of reflex seizures that are exclusively induced by a specific type of exercise. Many patients with exercise-induced reflex seizures exhibit drug-resistance, and are therefore advised to avoid the triggering exercise. Here, we describe a focal epilepsy patient with shadowboxing-induced reflex seizures. His semiology included focal aware seizures with speech and behavioral arrest that evolved to head version to the right, preceded by cephalic aura. We identified a specific motion that induced these seizures during shadowboxing using video-electroencephalographic recording, and the patient was able to continue boxing by avoiding this motion. We speculate that a broad brain network may be the pathological substrate of his exercise-induced reflex seizures. Identification of the specific motion that induces exercise-induced reflex seizures is useful for not only understanding the underlying pathophysiology, but also for minimizing the therapeutic restriction of the exercise.

DOI： 10.1016/j.ebr.2022.100543

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脊髄炎や脱髄と鑑別を要した脊髄硬膜動静脈瘻(SDAVF)の1例

林田仁志, 眞崎勝久, 緒方英紀, 山崎亮, 磯部紀子

臨床神経学 61 ( 12 ) 887 - 887 2021.12

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IgG4抗LGI4抗体はランビエ絞輪juxta-paranodeを標的とするCIDPの新たな自己抗体である

張旭, 緒方英紀, 今村友裕, 藤井敬之, 山嵜亮, 磯部紀子, 吉良潤一

末梢神経 32 ( 2 ) 239 - 239 2021.12

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【神経疾患とモノクローナル抗体】神経疾患治療とモノクローナル抗体抗CD20抗体オクレリズマブ

福元尚子, 磯部紀子

39 ( 12 ) 1496 - 1498 2021.12

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くも膜下出血後の水頭症に対するLPシャント術後にパーキンソン症候群をきたした1例

竹内創, 眞崎勝久, 緒方英紀, 山崎亮, 磯部紀子

臨床神経学 61 ( 12 ) 889 - 889 2021.12

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抗NF155抗体陽性CIDPの寛解無治療または少量ステロイド薬で神経症候・検査所見が改善した3症例の検討

緒方英紀, 川嵜淳史, 山嵜亮, 吉良潤一, 磯部紀子

末梢神経 32 ( 2 ) 256 - 256 2021.12

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脊髄C7、8前角障害により右手第3、4指下垂指を来した一例

倉沢亮, 眞崎勝久, 松下拓也, 松瀬大, 山崎亮, 磯部紀子

臨床神経学 61 ( 11 ) 780 - 780 2021.11

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Elevated mycobacterium avium subsp. paratuberculosis (MAP) antibody titer in Japanese multiple sclerosis. International journal

Fumie Hayashi, Noriko Isobe, Davide Cossu, Kazumasa Yokoyama, Ayako Sakoda, Takuya Matsushita, Nobutaka Hattori, Jun-Ichi Kira

Journal of neuroimmunology 360 577701 - 577701 2021.11

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DOI： 10.1016/j.jneuroim.2021.577701
抗PM/Scl-75抗体陽性で全身性強皮症に壊死性筋症を合併した一例

津村周, 前田泰宏, 眞崎勝久, 松下拓也, 渡邉充, 山崎亮, 吉良潤一, 磯部紀子

臨床神経学 61 ( 11 ) 779 - 779 2021.11

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肺小細胞癌に伴う傍腫瘍性視神経症に対してステロイド治療が奏功した1例

浅原健一郎, 秋山雅人, 石津正崇, 石川桂二郎, 塩瀬聡美, 吉冨健志, 松吉彩乃, 林史恵, 眞崎勝久, 磯部紀子, 園田康平

神経眼科 38 ( 増補1 ) 84 - 84 2021.11

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胸腺腫を合併した抗contactin-1抗体陽性ニューロパチー3例の臨床的特徴

緒方英紀, 山崎亮, 西嶌春生, 桑原基, 磯部紀子

神経免疫学 26 ( 1 ) 108 - 108 2021.10

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間接蛍光抗体法による多発性硬化症患者血清中の抗オリゴデンドロサイト抗体の検討

藤井敬之, 宮地佑希野, 山崎亮, 土本大介, 迫田礼子, 福元尚子, 松下拓也, 中別府雄作, 吉良潤一, 磯部紀子

神経免疫学 26 ( 1 ) 122 - 122 2021.10

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LGI4-IgG4はLGI4とADAM22の蛋白間相互作用を阻害して脱髄を起こすCIDPの新たなノド抗体である

張旭, 緒方英紀, 今村友裕, 藤井敬之, グザリアイ・ママティジャン, 山崎亮, 磯部紀子, 吉良潤一

神経免疫学 26 ( 1 ) 109 - 109 2021.10

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【多発性硬化症と視神経脊髄炎update-基礎・臨床研究の最新知見-】脱髄性疾患の基礎update 脱髄性疾患の環境疫学と遺伝学

林史恵, 磯部紀子

日本臨床 79 ( 10 ) 1459 - 1464 2021.10

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アストログリアコネキシン43は慢性多発性硬化症モデルに対する新規治療標的である(Astroglial connexin 43 is a novel therapeutic target for chronic multiple sclerosis model)

Ozdemir Ezgi, 山崎亮, 永田諭, 山口浩雄, 真崎勝久, 吉良潤一, 竹内英之, 磯部紀子

神経免疫学 26 ( 1 ) 129 - 129 2021.10

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再発寛解型多発性硬化症におけるfingolimod内服下での喫煙と再発の検討

田中栄蔵, 渡邉充, 福元尚子, 眞崎勝久, 松下拓也, 磯部紀子

神経免疫学 26 ( 1 ) 112 - 112 2021.10

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多発性硬化症病初期から進行期まで途切れのない治療の必要性

磯部紀子

神経免疫学 26 ( 1 ) 89 - 89 2021.10

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多発性硬化症の疾患修飾薬使用下での再発に関連する遺伝因子

松下拓也, 田中栄蔵, 渡邉充, 福元尚子, 山本健, 山崎亮, 吉良潤一, 磯部紀子

神経免疫学 26 ( 1 ) 112 - 112 2021.10

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多発性硬化症・視神経脊髄炎の治療トレンド最前線多発性硬化症において期待される新たな治療戦略

磯部紀子

神経治療学 38 ( 6 ) S122 - S122 2021.10

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多発性硬化症患者におけるmycobacterium avium subsp.paratuberculosis抗体の上昇

林史恵, Cossu Davide, 横山和正, 迫田礼子, 松下拓也, 服部信孝, 吉良潤一, 磯部紀子

神経免疫学 26 ( 1 ) 121 - 121 2021.10

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多系統萎縮症の早期脱髄病巣における活性化ミクログリア・マクロファージとコネキシン蛋白群脱落

眞崎勝久, 西村由宇慈, 松瀬大, 山口浩雄, 田中辰典, 山崎亮, 岩城徹, 吉良潤一, 磯部紀子

神経免疫学 26 ( 1 ) 139 - 139 2021.10

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小脳型多系統萎縮症/一次進行型多発性硬化症モデルマウスの樹立とこれら疾患の新規創薬ターゲットの探索

山口浩雄, 松瀬大, 眞崎勝久, 雑賀徹, 西村由宇慈, 田中辰典, 田中謙二, 山崎亮, 吉良潤一, 磯部紀子

神経治療学 38 ( 6 ) S274 - S274 2021.10

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日本人多発性硬化症患者における血清ニューロフィラメントとMRIパラメータとの関連

福元尚子, 渡邉充, 松下拓也, 眞崎勝久, Leppert David, Kuhle Jens, 吉良潤一, 磯部紀子

神経免疫学 26 ( 1 ) 102 - 102 2021.10

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第5回全国調査からみる多発性硬化症の重症度に寄与する因子の検討

渡邉充, 磯部紀子, 新野正明, 中島一郎, 松下拓也, 酒井康成, 中原仁, 河内泉, 越智博文, 中辻裕司, 中村好一, 中村幸志, 坂田清美, 松井真, 桑原聡, 吉良潤一

神経免疫学 26 ( 1 ) 119 - 119 2021.10

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胸腺腫を合併した抗contactin-1抗体陽性ニューロパチー3例の臨床的特徴

緒方英紀, 山崎亮, 西嶌春生, 桑原基, 磯部紀子

神経免疫学 26 ( 1 ) 108 - 108 2021.10

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脊髄炎と鑑別を要した、腰椎レベルにシャントのある脊髄硬膜動静脈瘻(SDAVF)4例の臨床症状・画像所見の検討

林田仁志, 眞崎勝久, 緒方英紀, 松瀬大, 山崎亮, 磯部紀子

神経免疫学 26 ( 1 ) 127 - 127 2021.10

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多発性硬化症における遺伝的要因

磯部紀子

福岡医学雑誌 112 ( 3 ) 171 - 175 2021.9

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Chromosomally integrated HHV-6を伴った抗NMDA受容体脳炎の1例

岩尾和紀, 渡邉充, 向野隆彦, 藤井敬之, 山崎亮, 磯部紀子

26 ( 2 ) 45 - 45 2021.9

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T細胞受容体γ鎖領域欠失型コピー数変異と多発性硬化症末梢血γδT細胞分画の変化

古再麗阿依買買提江, 渡邉充, 篠田紘司, 中村優理, 迫田礼子, 磯部紀子, 松下拓也, 吉良潤一

臨床神経学 61 ( Suppl. ) S324 - S324 2021.9

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【神経免疫メカニズムと疾患神経系と免疫系を結ぶ分子機構の解明からバイオマーカー・治療標的の探索まで】(第2章)神経免疫と疾患神経免疫疾患:近年の動向多発性硬化症:遺伝因子研究

磯部紀子

実験医学 39 ( 15 ) 2451 - 2454 2021.9

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多発性硬化症(MS)は、発症に遺伝的要因と環境要因がかかわる多因子疾患である。遺伝的要因では、主要組織適合抗原(MHC)領域がMSの発症に最も大きく寄与し、なかでもヒト白血球抗原(human leukocyte antigen:HLA)クラスII領域に位置するHLA-DRB1*15:01アレルが世界的に最大のリスクアレルである。その他、200ヶ所以上の非HLA領域の遺伝子領域もMSの発症に寄与し、遺伝的要因と環境要因の間にも相互作用が存在することが知られている。(著者抄録)
再発寛解型多発性硬化症におけるfingolimod内服下での喫煙と再発の検討

田中栄蔵, 渡邉充, 松下拓也, 磯部紀子, 吉良潤一

臨床神経学 61 ( Suppl. ) S324 - S324 2021.9

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Update on the management of multiple sclerosis during the COVID-19 pandemic and post pandemic: An international consensus statement. International journal

Journal of neuroimmunology 357 577627 - 577627 2021.8

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DOI： 10.1016/j.jneuroim.2021.577627
Clearance of peripheral nerve misfolded mutant protein by infiltrated macrophages correlates with motor neuron disease progression. International journal

Wataru Shiraishi, Ryo Yamasaki, Yu Hashimoto, Senri Ko, Yuko Kobayakawa, Noriko Isobe, Takuya Matsushita, Jun-Ichi Kira

Scientific reports 11 ( 1 ) 16438 - 16438 2021.8

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DOI： 10.1038/s41598-021-96064-6
PON1 Q192R is associated with high platelet reactivity with clopidogrel in patients undergoing elective neurointervention: A prospective single-center cohort study International journal

Koji Tanaka, Shoji Matsumoto, Gulibahaer Ainiding, Ichiro Nakahara, Hidehisa Nishi, Tetsuya Hashimoto, Tsuyoshi Ohta, Nobutake Sadamasa, Ryota Ishibashi, Masanori Gomi, Makoto Saka, Haruka Miyata, Sadayoshi Watanabe, Takuya Okata, Kazutaka Sonoda, Junpei Koge, Kyoko M. Iinuma, Konosuke Furuta, Izumi Nagata, Keitaro Matsuo, Takuya Matsushita, Noriko Isobe, Ryo Yamasaki, Jun-ichi Kira

PLOS ONE 16 ( 8 ) e0254067 - e0254067 2021.8

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DOI： 10.1371/journal.pone.0254067
新規小脳型多系統萎縮症モデルのCSF-1R阻害剤治療

松瀬大, 山口浩雄, 眞崎勝久, 西村由宇慈, 田中辰典, 雑賀徹, 田中謙二, 山崎亮, 吉良潤一, 磯部紀子

パーキンソン病・運動障害疾患コングレスプログラム・抄録集 15回 92 - 92 2021.7

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視神経脊髄炎スペクトラム障害(NMOSD)の病態に基づく治療の未来

磯部紀子

日本難病看護学会誌 26 ( 1 ) 27 - 27 2021.6

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多発性硬化症におけるエピジェネティクス機構

磯部紀子

39 ( 1 ) 59 - 62 2021.1

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多発性硬化症(multiple sclerosis:MS)は中枢神経系の自己免疫性脱髄性疾患である。若年女性に好発し、その発症に遺伝的要因と環境要因が関わる多因子疾患である。世界においてMSの有病率は増加傾向が続いており、特に女性における増加が著しいとされる。その要因として、環境要因の変化、遺伝的要因と環境要因との相互作用に加え、エピジェネティックな機構の関与も想定されている。MSについての疫学を含む総論的事項から、発症や経過に関わるエピジェネティックな機構まで、最新の研究で得られた知見も含め紹介する。(著者抄録)
HLA genotype-clinical phenotype correlations in multiple sclerosis and neuromyelitis optica spectrum disorders based on Japan MS/NMOSD Biobank data. International journal

Mitsuru Watanabe, Yuri Nakamura, Shinya Sato, Masaaki Niino, Hikoaki Fukaura, Masami Tanaka, Hirofumi Ochi, Takashi Kanda, Yukio Takeshita, Takanori Yokota, Yoichiro Nishida, Makoto Matsui, Shigemi Nagayama, Susumu Kusunoki, Katsuichi Miyamoto, Masanori Mizuno, Izumi Kawachi, Etsuji Saji, Takashi Ohashi, Shun Shimohama, Shin Hisahara, Kazutoshi Nishiyama, Takahiro Iizuka, Yuji Nakatsuji, Tatsusada Okuno, Kazuhide Ochi, Akio Suzumura, Ken Yamamoto, Yuji Kawano, Shoji Tsuji, Makoto Hirata, Ryuichi Sakate, Tomonori Kimura, Yuko Shimizu, Akiko Nagaishi, Kazumasa Okada, Fumie Hayashi, Ayako Sakoda, Katsuhisa Masaki, Koji Shinoda, Noriko Isobe, Takuya Matsushita, Jun-Ichi Kira

Scientific reports 11 ( 1 ) 607 - 607 2021.1

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DOI： 10.1038/s41598-020-79833-7
A new clustering method identifies multiple sclerosis-specific T-cell receptors. International journal

Fumie Hayashi, Noriko Isobe, Jacob Glanville, Takuya Matsushita, Guzailiayi Maimaitijiang, Shoko Fukumoto, Mitsuru Watanabe, Katsuhisa Masaki, Jun-Ichi Kira

Annals of clinical and translational neurology 8 ( 1 ) 163 - 176 2021.1

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DOI： 10.1002/acn3.51264
Early decrease in intermediate monocytes in peripheral blood is characteristic of multiple system atrophy-cerebellar type. Reviewed International journal

Dai Matsuse, Ryo Yamasaki, Guzailiayi Maimaitijiang, Hiroo Yamaguchi, Katsuhisa Masaki, Noriko Isobe, Takuya Matsushita, Jun-Ichi Kira

Journal of neuroimmunology 349 577395 - 577395 2020.12

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DOI： 10.1016/j.jneuroim.2020.577395
第5回全国疫学調査が示す多発性硬化症・視神経脊髄炎総患者数の顕著な増加傾向の持続

磯部紀子, 新野正明, 松下拓也, 中村優理, 中島一郎, 渡邉充, 酒井康成, 迫田礼子, 中原仁, 河内泉, 越智博文, 中辻裕司, 福元尚子, 林史恵, 中村好一, 中村幸志, 坂田清美, 嶋田莉奈子, 松井真

臨床神経学 60 ( Suppl. ) S328 - S328 2020.11

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Genetic factors for susceptibility to and manifestations of neuromyelitis optica. International journal

Takuya Matsushita, Katsuhisa Masaki, Noriko Isobe, Shinya Sato, Ken Yamamoto, Yuri Nakamura, Mitsuru Watanabe, Toshihiko Suenaga, Jun-Ichi Kira

Annals of clinical and translational neurology 7 ( 11 ) 2082 - 2093 2020.11

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DOI： 10.1002/acn3.51147
Optic, trigeminal, and facial neuropathy related to anti-neurofascin 155 antibody. Reviewed International journal

Hidenori Ogata, Xu Zhang, Saeko Inamizu, Ken-Ichiro Yamashita, Ryo Yamasaki, Takuya Matsushita, Noriko Isobe, Akio Hiwatashi, Shozo Tobimatsu, Jun-Ichi Kira

Annals of clinical and translational neurology 7 ( 11 ) 2297 - 2309 2020.11

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DOI： 10.1002/acn3.51220
【免疫性神経疾患update-基礎・臨床研究の最新知見-】多発性硬化症・視神経脊髄炎の疫学

磯部紀子, 吉良潤一

日本臨床 78 ( 11 ) 1811 - 1816 2020.11

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Distinct microglial and macrophage distribution patterns in the concentric and lamellar lesions in Baló's disease and neuromyelitis optica spectrum disorders International journal

Shotaro Hayashida, Katsuhisa Masaki, Satoshi O. Suzuki, Ryo Yamasaki, Mitsuru Watanabe, Sachiko Koyama, Noriko Isobe, Takuya Matsushita, Kazuya Takahashi, Takeshi Tabira, Toru Iwaki, Jun‐ichi Kira

30 ( 6 ) 1144 - 1157 2020.11

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TMEM119 and purinergic receptor P2Y12 (P2RY12), which are not expressed by recruited peripheral blood macrophages, are proposed to discriminate microglia from macrophages. Therefore, we investigated the distribution patterns of microglia and macrophages in 10 concentric lesions from four autopsied Baló's disease cases and one neuromyelitis optica spectrum disorder (NMOSD) case, using quantitative immunohistochemistry for the markers TMEM119, P2RY12, CD68, CD163 and GLUT5. Three cases with Baló's disease had distal oligodendrogliopathy (DO) showing preferential loss of myelin-associated glycoprotein and early active demyelination in the outermost demyelinating layer (termed DMY-MO). In DMY-MO with DO, TMEM119-positive activated microglia expressing upregulated GLUT5 but markedly downregulated P2RY12 were significantly increased. These activated microglia expressed inducible nitric oxide synthase. Oligodendrocytes and their precursors showed apoptotic-like nuclear condensation in DMY-MO. TMEM119-negative and CD68/CD163-positive macrophages were distributed throughout the lesion center of DMY-MO with DO and these cells demonstrated foamy morphology only in the inner portion but not in the outer portion. In concentric demyelinating lesions from another Baló's case and lamellar demyelinating lesions in an NMOSD case, which had late active demyelination without DO, the densities of TMEM119-, GLUT5- and P2RY12-positive microglia with ramified morphology were significantly increased in myelinated layers but not in demyelinating layers. In particular, in the NMOSD case, TMEM119-positive microglia were confined to the outer portion of the myelinated layers. CD68-positive macrophages with foamy morphology also expressing CD163 accumulated in myelinated as well as in demyelinated layers. These findings suggest that activated microglia expressing TMEM119 and GLUT5, but not P2RY12, are associated with apoptosis of oligodendrocytes in the leading edge of Baló's concentric lesions with DO, whereas TMEM119-, GLUT5- and P2RY12-positive microglia with ramified morphology are associated with myelin preservation in concentric lesions without DO in Baló's disease and NMOSD. These two types of microglia appear to play distinct roles in the formation of concentric lesions.

DOI： 10.1111/bpa.12898
Optic, trigeminal, and facial neuropathy related to anti-neurofascin 155 antibody. Reviewed International journal

Hidenori Ogata, Xu Zhang, Saeko Inamizu, Ken-Ichiro Yamashita, Ryo Yamasaki, Takuya Matsushita, Noriko Isobe, Akio Hiwatashi, Shozo Tobimatsu, Jun-Ichi Kira

Annals of clinical and translational neurology 7 ( 11 ) 2297 - 2309 2020.11

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DOI： 10.1002/acn3.51220
第5回全国調査が示す多発性硬化症・視神経脊髄炎総患者数の増加

磯部紀子, 新野正明, 松下拓也, 中村優理, 中島一郎, 渡邉充, 酒井康成, 迫田礼子, 中原仁, 河内泉, 越智博文, 中辻裕司, 福元尚子, 林史恵, 中村好一, 中村幸志, 坂田清美, 嶋田莉奈子, 松井真, 吉良潤一

神経免疫学 25 ( 1 ) 129 - 129 2020.10

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Two genetic variants explain the association of European ancestry with multiple sclerosis risk in African-Americans. Reviewed International journal

Nathan Nakatsuka, Nick Patterson, Nikolaos A Patsopoulos, Nicolas Altemose, Arti Tandon, Ashley H Beecham, Jacob L McCauley, Noriko Isobe, Stephen Hauser, Philip L De Jager, David A Hafler, Jorge R Oksenberg, David Reich

Scientific reports 10 ( 1 ) 16902 - 16902 2020.10

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DOI： 10.1038/s41598-020-74035-7
フィンゴリモドを長期使用した日本人多発性硬化症患者で残存する疾患活動性に関するリンパ球分画の同定

渡邉充, 松尾江梨子, グザリアイ・ママティジャン, 迫田礼子, 福元尚子, 林史恵, 眞崎勝久, 磯部紀子, 松下拓也, 吉良潤一

神経免疫学 25 ( 1 ) 142 - 142 2020.10

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フマル酸ジメチル導入による多発性硬化症再発抑制効果とその関連因子

松下拓也, 磯部紀子, 眞崎勝久, 渡邉充, 福元尚子, 林史恵, 中村優理, 迫田礼子, 吉良潤一

神経免疫学 25 ( 1 ) 128 - 128 2020.10

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免疫介在性疾患の病因追究手段としてのHLAその他の遺伝子解析手法の原理と臨床的意義づけ

磯部紀子

神経免疫学 25 ( 1 ) 58 - 58 2020.10

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日本人多発性硬化症患者における高次脳機能(BICAMS)とMRIパラメータとの関連

福元尚子, 渡邉充, 新野正明, 磯部紀子, 松下拓也, 眞崎勝久, 迫田礼子, 林史恵, 吉良潤一

神経免疫学 25 ( 1 ) 139 - 139 2020.10

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Continued Increase of Multiple Sclerosis and Neuromyelitis Optica in Japan: Updates from the 5th Nationwide Survey

Jun-ichi Kira, Noriko Isobe, Masaaki Niino, Takuya Matsushita, Yuri Nakamura, Ichiro Nakashima, Mitsuru Watanabe, Yasunari Sakai, Ayako Sakoda, Jin Nakahara, Izumi Kawachi, Hirofumi Ochi, Yuji Nakatsuji, Yusei Miyazaki, Juichi Fujimori, Kenji Kufukihara, Tatsusada Okuno, Shoko Fukumoto, Fumie Hayashi, Kousuke Yonemoto, Ryoji Taira, Yoshikazu Nakamura, Koshi Nakamura, Kiyomi Sakata, Rinako Shimada, Makoto Matsui

ANNALS OF NEUROLOGY 88 S199 - S200 2020.10

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Painful trigeminal neuropathy associated with anti-Plexin D1 antibody. Reviewed International journal

Takayuki Fujii, Ryo Yamasaki, Yukino Miyachi, Kyoko Iinuma, Yu Hashimoto, Noriko Isobe, Takuya Matsushita, Jun-Ichi Kira

Neurology(R) neuroimmunology & neuroinflammation 7 ( 5 ) 2020.9

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DOI： 10.1212/NXI.0000000000000819
Early decrease in intermediate monocytes in peripheral blood is characteristic of multiple system atrophy-cerebellar type. Reviewed International journal

Dai Matsuse, Ryo Yamasaki, Guzailiayi Maimaitijiang, Hiroo Yamaguchi, Katsuhisa Masaki, Noriko Isobe, Takuya Matsushita, Jun-Ichi Kira

Journal of neuroimmunology 349 577395 - 577395 2020.9

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DOI： 10.1016/j.jneuroim.2020.577395
Two susceptible HLA-DRB1 alleles for multiple sclerosis differentially regulate anti-JC virus antibody serostatus along with fingolimod. Reviewed International journal

Mitsuru Watanabe, Yuri Nakamura, Noriko Isobe, Masami Tanaka, Ayako Sakoda, Fumie Hayashi, Yuji Kawano, Ryo Yamasaki, Takuya Matsushita, Jun-Ichi Kira

Journal of neuroinflammation 17 ( 1 ) 206 - 206 2020.7

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DOI： 10.1186/s12974-020-01865-7
Risk HLA-DRB1 alleles differentially influence brain and lesion volumes in Japanese patients with multiple sclerosis. Reviewed International journal

Shoko Fukumoto, Yuri Nakamura, Mitsuru Watanabe, Noriko Isobe, Takuya Matsushita, Ayako Sakoda, Akio Hiwatashi, Koji Shinoda, Ryo Yamasaki, Akira Tsujino, Jun-Ichi Kira

Journal of the neurological sciences 413 116768 - 116768 2020.6

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DOI： 10.1016/j.jns.2020.116768
Double positivity for anti-N-methyl-d-aspartate receptor and anti-aquaporin-4 antibodies in a patient presenting with hypersomnolence, personality change, and reduced spontaneity

Motoi Yoshimura, Taira Uehara, Eizo Tanaka, Toshiki Okadome, Takahiro Yamaguchi, Yasuhiro Maeda, Noriko Isobe, Takuya Matsushita, Ryo Yamasaki, Jun ichi Kira

Clinical and Experimental Neuroimmunology 11 ( S1 ) 53 - 56 2020.3

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DOI： 10.1111/cen3.12571
Contribution of cortical lesions to cognitive impairment in Japanese patients with multiple sclerosis. Reviewed International journal

Koji Shinoda, Takuya Matsushita, Yuri Nakamura, Katsuhisa Masaki, Shiori Sakai, Haruka Nomiyama, Osamu Togao, Akio Hiwatashi, Masaaki Niino, Noriko Isobe, Jun-Ichi Kira

Scientific reports 10 ( 1 ) 5228 - 5228 2020.3

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DOI： 10.1038/s41598-020-61012-3
Contribution of cortical lesions to cognitive impairment in Japanese patients with multiple sclerosis. Reviewed International journal

Koji Shinoda, Takuya Matsushita, Yuri Nakamura, Katsuhisa Masaki, Shiori Sakai, Haruka Nomiyama, Osamu Togao, Akio Hiwatashi, Masaaki Niino, Noriko Isobe, Jun-Ichi Kira

Scientific reports 10 ( 1 ) 5228 - 5228 2020.3

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DOI： 10.1038/s41598-020-61012-3
Unique HLA haplotype associations in IgG4 anti-neurofascin 155 antibody-positive chronic inflammatory demyelinating polyneuropathy. Reviewed International journal

Hidenori Ogata, Noriko Isobe, Xu Zhang, Ryo Yamasaki, Takayuki Fujii, Akira Machida, Nobutoshi Morimoto, Kenichi Kaida, Teruaki Masuda, Yukio Ando, Motoi Kuwahara, Susumu Kusunoki, Yuri Nakamura, Takuya Matsushita, Jun-Ichi Kira

Journal of neuroimmunology 339 577139 - 577139 2020.2

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DOI： 10.1016/j.jneuroim.2019.577139
Environmental risk factors for multiple sclerosis in Japanese people. Reviewed International journal

Ayako Sakoda, Takuya Matsushita, Yuri Nakamura, Mitsuru Watanabe, Koji Shinoda, Katsuhisa Masaki, Noriko Isobe, Ryo Yamasaki, Jun-Ichi Kira

Multiple sclerosis and related disorders 38 101872 - 101872 2020.2

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DOI： 10.1016/j.msard.2019.101872
Central nervous system-specific antinuclear antibodies in patients with multiple sclerosis. Reviewed International journal

Takayuki Fujii, Ryo Yamasaki, Yukino Miyachi, Satoshi Nagata, Guzailiayi Maimaitijiang, Yuri Nakamura, Koji Shinoda, Takuya Matsushita, Noriko Isobe, Jun-Ichi Kira

Journal of the neurological sciences 409 116619 - 116619 2020.2

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DOI： 10.1016/j.jns.2019.116619
Unique HLA haplotype associations in IgG4 anti-neurofascin 155 antibody-positive chronic inflammatory demyelinating polyneuropathy. Reviewed International journal

Hidenori Ogata, Noriko Isobe, Xu Zhang, Ryo Yamasaki, Takayuki Fujii, Akira Machida, Nobutoshi Morimoto, Kenichi Kaida, Teruaki Masuda, Yukio Ando, Motoi Kuwahara, Susumu Kusunoki, Yuri Nakamura, Takuya Matsushita, Jun-Ichi Kira

Journal of neuroimmunology 339 577139 - 577139 2020.2

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DOI： 10.1016/j.jneuroim.2019.577139
Central nervous system-specific antinuclear antibodies in patients with multiple sclerosis. Reviewed International journal

Takayuki Fujii, Ryo Yamasaki, Yukino Miyachi, Satoshi Nagata, Guzailiayi Maimaitijiang, Yuri Nakamura, Koji Shinoda, Takuya Matsushita, Noriko Isobe, Jun-Ichi Kira

Journal of the neurological sciences 409 116619 - 116619 2020.2

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DOI： 10.1016/j.jns.2019.116619
A case of overlapping adult-onset linear scleroderma and Parry-Romberg syndrome presenting with widespread ipsilateral neurogenic involvement. Reviewed International journal

Ryo Yamasaki, Tomomi Yonekawa, Saeko Inamizu, Koji Shinoda, Hirofumi Ochi, Takuya Matsushita, Noriko Isobe, Gaku Tsuji, Shoko Sadashima, Yuki Kuma, Yoshinao Oda, Toru Iwaki, Masutaka Furue, Jun-Ichi Kira

Neuropathology : official journal of the Japanese Society of Neuropathology 40 ( 1 ) 109 - 115 2020.2

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DOI： 10.1111/neup.12614
A case of overlapping adult-onset linear scleroderma and Parry-Romberg syndrome presenting with widespread ipsilateral neurogenic involvement. Reviewed International journal

Ryo Yamasaki, Tomomi Yonekawa, Saeko Inamizu, Koji Shinoda, Hirofumi Ochi, Takuya Matsushita, Noriko Isobe, Gaku Tsuji, Shoko Sadashima, Yuki Kuma, Yoshinao Oda, Toru Iwaki, Masutaka Furue, Jun-Ichi Kira

Neuropathology : official journal of the Japanese Society of Neuropathology 40 ( 1 ) 109 - 115 2020.2

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DOI： 10.1111/neup.12614
Oligodendroglial connexin 47 regulates neuroinflammation upon autoimmune demyelination in a novel mouse model of multiple sclerosis. Reviewed International journal

Yinan Zhao, Ryo Yamasaki, Hiroo Yamaguchi, Satoshi Nagata, Hayato Une, Yiwen Cui, Katsuhisa Masaki, Yuko Nakamuta, Kyoko Iinuma, Mitsuru Watanabe, Takuya Matsushita, Noriko Isobe, Jun-Ichi Kira

Proceedings of the National Academy of Sciences of the United States of America 117 ( 4 ) 2160 - 2169 2020.1

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DOI： 10.1073/pnas.1901294117
Intrathecal cytokine profile in neuropathy with anti-neurofascin 155 antibody. Reviewed International journal

Hidenori Ogata, Xu Zhang, Ryo Yamasaki, Takayuki Fujii, Akira Machida, Nobutoshi Morimoto, Kenichi Kaida, Teruaki Masuda, Yukio Ando, Motoi Kuwahara, Susumu Kusunoki, Yuri Nakamura, Takuya Matsushita, Noriko Isobe, Jun-Ichi Kira

Annals of clinical and translational neurology 6 ( 11 ) 2304 - 2316 2019.11

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DOI： 10.1002/acn3.50931
Intrathecal cytokine profile in neuropathy with anti-neurofascin 155 antibody. Reviewed International journal

Hidenori Ogata, Xu Zhang, Ryo Yamasaki, Takayuki Fujii, Akira Machida, Nobutoshi Morimoto, Kenichi Kaida, Teruaki Masuda, Yukio Ando, Motoi Kuwahara, Susumu Kusunoki, Yuri Nakamura, Takuya Matsushita, Noriko Isobe, Jun-Ichi Kira

Annals of clinical and translational neurology 6 ( 11 ) 2304 - 2316 2019.11

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DOI： 10.1002/acn3.50931
米食の予防効果は多発性硬化症ではみられるが視神経脊髄炎関連疾患ではみられない

迫田礼子, 松下拓也, 中村優理, 渡邉充, 篠田紘司, 磯部紀子, 吉良潤一

神経治療学 36 ( 6 ) S251 - S251 2019.10

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HLA-DRB1*15:01保有多発性硬化症患者は白質容積の萎縮が速く、DRB1*04:05保有者は病巣容積の増加が遅い

福元尚子, 中村優理, 渡邉充, 迫田礼子, 磯部紀子, 松下拓也, 吉良潤一

神経治療学 36 ( 6 ) S219 - S219 2019.10

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Intractable axonal neuropathy with multifocal peripheral nerve swelling in neuromyelitis optica spectrum disorders: A case report. Reviewed International journal

Yuri Mizuno, Koji Shinoda, Mitsuru Watanabe, Hidenori Ogata, Noriko Isobe, Takuya Matsushita, Ryo Yamasaki, Kimihiro Tanaka, Haruki Koike, Masahisa Katsuno, Jun-Ichi Kira

Multiple sclerosis and related disorders 35 16 - 18 2019.10

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DOI： 10.1016/j.msard.2019.06.033
日本人視神経脊髄炎とその臨床像に対する全ゲノム関連解析

松下拓也, 佐藤眞也, 山本健, 渡邉充, 中村優理, 磯部紀子, 吉良潤一

神経免疫学 24 ( 1 ) 93 - 93 2019.9

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Long-term use of interferon-β in multiple sclerosis increases Vδ1-Vδ2-Vγ9- γδ T cells that are associated with a better outcome. Reviewed International journal

16 ( 1 ) 179 - 179 2019.9

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BACKGROUND: We previously reported that Vδ2+Vγ9+ γδ T cells were significantly decreased in multiple sclerosis (MS) patients without disease-modifying therapies (untreated MS) and were negatively correlated with Expanded Disability Status Scale (EDSS) scores, suggesting protective roles of Vδ2+Vγ9+ γδ T cells. Interferon-β (IFN-β) is one of the first-line disease-modifying drugs for MS. However, no previous studies have reported changes in γδ T cell subsets under IFN-β treatment. Therefore, we aimed to clarify the effects of the long-term usage of IFN-β on γδ T cell subsets in MS patients. METHODS: Comprehensive flow cytometric immunophenotyping was performed in 35 untreated MS and 21 MS patients on IFN-β for more than 2 years (IFN-β-treated MS) including eight super-responders fulfilling no evidence of disease activity criteria, and 44 healthy controls (HCs). RESULTS: The percentages of Vδ2+Vγ9+ cells in γδ T cells were significantly lower in untreated and IFN-β-treated MS patients than in HCs. By contrast, the percentages of Vδ1-Vδ2-Vγ9- cells in γδ T cells were markedly higher in IFN-β-treated MS patients than in HCs and untreated MS patients (both p < 0.001). A significant negative correlation between the percentages of Vδ2+Vγ9+ cells in γδ T cells and EDSS scores was confirmed in untreated MS but not evident in IFN-β-treated MS. Moreover, class-switched memory B cells were decreased in IFN-β-treated MS compared with HCs (p < 0.001) and untreated MS patients (p = 0.006). Interestingly, the percentages of Vδ1-Vδ2-Vγ9- cells in γδ T cells were negatively correlated with class-switched memory B cell percentages in all MS patients (r = - 0.369, p = 0.005), and the percentages of Vδ1-Vδ2-Vγ9- cells in Vδ1-Vδ2- γδ T cells were negatively correlated with EDSS scores only in IFN-β super-responders (r = - 0.976, p < 0.001). CONCLUSIONS: The present study suggests that long-term usage of IFN-β increases Vδ1-Vδ2-Vγ9- γδ T cells, which are associated with a better outcome, especially in IFN-β super-responders. Thus, increased Vδ1-Vδ2-Vγ9- cells together with decreased class-switched memory B cells may contribute to the suppression of disease activity in MS patients under IFN-β treatment.

DOI： 10.1186/s12974-019-1574-5
MS/NMO 2 日本人における視神経脊髄炎の環境要因についての検討

迫田礼子, 松下拓也, 中村優理, 渡邉充, 篠田絋司, 磯部紀子, 吉良潤一

神経免疫学 24 ( 1 ) 120 - 120 2019.9

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MS/NMO1 HLA-DRB1*04:05陽性MS患者におけるサイトメガロウイルス(CMV)関連T細胞受容体の同定

林史恵, 磯部紀子, Glanville Jacob, 渡邉充, 松下拓也, 吉良潤一

神経免疫学 24 ( 1 ) 103 - 103 2019.9

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MS/NMO1 表現型不一致の一卵性品胎における多発性硬化症関連T細胞受容体レパトア解析

磯部紀子, 林史恵, 渡邉充, 松下拓也, 岡本幸市, 吉良潤一

神経免疫学 24 ( 1 ) 106 - 106 2019.9

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Serum GFAP and neurofilament light as biomarkers of disease activity and disability in NMOSD. Reviewed International journal

Mitsuru Watanabe, Yuri Nakamura, Zuzanna Michalak, Noriko Isobe, Christian Barro, David Leppert, Takuya Matsushita, Fumie Hayashi, Ryo Yamasaki, Jens Kuhle, Jun-Ichi Kira

Neurology 93 ( 13 ) e1299-e1311 2019.9

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DOI： 10.1212/WNL.0000000000008160
抗neurofascin 155抗体関連ニューロパチー全国調査結果

緒方英紀, 山崎亮, 磯部紀子, 角谷真人, 海田賢一, 松井真, 桑原聡, 楠進, 吉良潤一

神経免疫学 24 ( 1 ) 92 - 92 2019.9

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日本人多発性硬化症患者におけるHLAアリルの脳容積に対する影響

福元尚子, 中村優理, 渡邉充, 迫田礼子, 磯部紀子, 松下拓也, 吉良潤一

神経免疫学 24 ( 1 ) 134 - 134 2019.9

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Long-term use of interferon-β in multiple sclerosis increases Vδ1-Vδ2-Vγ9- γδ T cells that are associated with a better outcome. Reviewed International journal

16 ( 1 ) 179 - 179 2019.9

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DOI： 10.1186/s12974-019-1574-5
Serum GFAP and neurofilament light as biomarkers of disease activity and disability in NMOSD. Reviewed International journal

Mitsuru Watanabe, Yuri Nakamura, Zuzanna Michalak, Noriko Isobe, Christian Barro, David Leppert, Takuya Matsushita, Fumie Hayashi, Ryo Yamasaki, Jens Kuhle, Jun-Ichi Kira

Neurology 93 ( 13 ) e1299-e1311 2019.9

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DOI： 10.1212/WNL.0000000000008160
Sex-specific Tau methylation patterns and synaptic transcriptional alterations are associated with neural vulnerability during chronic neuroinflammation. Reviewed International journal

Journal of autoimmunity 101 56 - 69 2019.7

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DOI： 10.1016/j.jaut.2019.04.003
Recurrent rhombencephalomyelitis associated with allergen immunotherapy by mite antigen sublingual tablets. Reviewed International journal

Masakazu Kawajiri, Junpei Koge, Tetsuya Hashimoto, Takeshi Yamada, Noriko Isobe, Jun-Ichi Kira

eNeurologicalSci 15 100190 - 100190 2019.6

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DOI： 10.1016/j.ensci.2019.100190
Discriminative clinical and neuroimaging features of motor-predominant hereditary diffuse leukoencephalopathy with axonal spheroids and primary progressive multiple sclerosis: A preliminary cross-sectional study. Reviewed International journal

Ban-Yu Saitoh, Ryo Yamasaki, Akio Hiwatashi, Takuya Matsushita, Shintaro Hayashi, Yoshihiro Mitsunaga, Yasuhiro Maeda, Noriko Isobe, Kunihiro Yoshida, Shu-Ichi Ikeda, Jun-Ichi Kira

Multiple sclerosis and related disorders 31 22 - 31 2019.6

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DOI： 10.1016/j.msard.2019.03.008
Link between HLA alleles and anti-NMDAR encephalitis. Reviewed International journal

Noriko Isobe

Journal of neurology, neurosurgery, and psychiatry 90 ( 6 ) 626 - 626 2019.6

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DOI： 10.1136/jnnp-2018-319925
Discriminative clinical and neuroimaging features of motor-predominant hereditary diffuse leukoencephalopathy with axonal spheroids and primary progressive multiple sclerosis: A preliminary cross-sectional study. Reviewed International journal

Ban-Yu Saitoh, Ryo Yamasaki, Akio Hiwatashi, Takuya Matsushita, Shintaro Hayashi, Yoshihiro Mitsunaga, Yasuhiro Maeda, Noriko Isobe, Kunihiro Yoshida, Shu-Ichi Ikeda, Jun-Ichi Kira

Multiple sclerosis and related disorders 31 22 - 31 2019.6

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DOI： 10.1016/j.msard.2019.03.008
Recurrent rhombencephalomyelitis associated with allergen immunotherapy by mite antigen sublingual tablets. Reviewed International journal

Masakazu Kawajiri, Junpei Koge, Tetsuya Hashimoto, Takeshi Yamada, Noriko Isobe, Jun-Ichi Kira

eNeurologicalSci 15 100190 - 100190 2019.6

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DOI： 10.1016/j.ensci.2019.100190
Link between HLA alleles and anti-NMDAR encephalitis. Reviewed International journal

Noriko Isobe

Journal of neurology, neurosurgery, and psychiatry 90 ( 6 ) 626 - 626 2019.6

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DOI： 10.1136/jnnp-2018-319925
MOG antibody disease manifesting as progressive cognitive deterioration and behavioral changes with primary central nervous system vasculitis. Reviewed International journal

Toshikazu Baba, Koji Shinoda, Mitsuru Watanabe, Shoko Sadashima, Dai Matsuse, Noriko Isobe, Ryo Yamasaki, Kimihiko Kaneko, Toshiyuki Takahashi, Toru Iwaki, Jun-Ichi Kira

Multiple sclerosis and related disorders 30 48 - 50 2019.5

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DOI： 10.1016/j.msard.2019.01.053
Cerebrospinal fluid cytokine/chemokine/growth factor profiles in idiopathic hypertrophic pachymeningitis. Reviewed International journal

Xu Zhang, Takayuki Fujii, Hidenori Ogata, Ryo Yamasaki, Katsuhisa Masaki, Yiwen Cui, Takuya Matsushita, Noriko Isobe, Jun-Ichi Kira

Journal of neuroimmunology 330 38 - 43 2019.5

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DOI： 10.1016/j.jneuroim.2019.01.010
Helicobacter pylori infection and demyelinating disease of the central nervous system. Reviewed International journal

Jun-Ichi Kira, Noriko Isobe

Journal of neuroimmunology 329 14 - 19 2019.4

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DOI： 10.1016/j.jneuroim.2018.06.017
日本人多発性硬化症における疾患修飾薬関連進行性多巣性白質脳症のリスクにHLAクラスIIアリル多型が関与

渡邉充, 中村優理, 磯部紀子, 松下拓也, 迫田礼子, 林史恵, 吉良潤一

日本内科学会雑誌 108 ( Suppl. ) 205 - 205 2019.2

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多発性硬化症患者におけるT細胞受容体レパトアの解析

林史恵, 磯部紀子, Maimaitijiang Guzailiayi, 中村優理, 篠田紘司, 松下拓也, 吉良潤一

臨床神経学 58 ( Suppl. ) S217 - S217 2018.12

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多地点接続症例検討遠隔会議におけるユーザー体感品質を考慮した技術的課題

富松俊太, 工藤孔梨子, 森山智彦, 平井康之, 磯部紀子, 清水周次

日本遠隔医療学会学術大会プログラム・抄録集 22回 157 - 157 2018.11

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Connexin 30 deficiency attenuates chronic but not acute phases of experimental autoimmune encephalomyelitis through induction of neuroprotective microglia

Fang, M., Yamasaki, R., Li, G., Masaki, K., Yamaguchi, H., Fujita, A., Isobe, N., Kira, J.-I.

Frontiers in Immunology 9 ( NOV ) 2018.11

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DOI： 10.3389/fimmu.2018.02588
Facial onset sensory and motor neuronopathy症候群は早期からoral phase dysphagiaを呈する

渡邉充, 白石渉, 山崎亮, 磯部紀子, 吉良潤一

神経治療学 35 ( 6 ) S212 - S212 2018.11

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【中枢神経系脱髄疾患の最前線-抗MOG抗体の関与を考える】多発性硬化症に自己抗体の関与はあるか遺伝学

磯部紀子

36 ( 11 ) 1300 - 1302 2018.11

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日本人多発性硬化症ではHLA-DRB1*15:01がJCV感染リスクを下げDR4がリスクを上げる

渡邉充, 中村優理, 磯部紀子, 松下拓也, 迫田礼子, 林史恵, 吉良潤一

23 ( 2 ) 187 - 187 2018.10

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問題症例の神経筋診断左肩に限局する不随意運動を呈した一例

稲水佐江子, 藤下幸穂, 山下謙一郎, 磯部紀子, 山崎亮, 吉良潤一

臨床神経生理学 46 ( 5 ) 405 - 405 2018.10

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多地点接続症例検討遠隔会議におけるユーザー体感品質を考慮した技術的課題

富松俊太, 工藤孔梨子, 森山智彦, 平井康之, 磯部紀子, 清水周次

日本遠隔医療学会雑誌 14 ( 2 ) 155 - 158 2018.10

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本研究では定例で行われる多地点接続の遠隔会議におけるユーザー体感品質に関する技術的課題の抽出を目的とし、インドネシアの7大学の附属病院および九州大学病院との間で行われた神経内科の症例検討会議を対象に調査を行った。合計9回の遠隔会議に出席した医師とネットワークエンジニアに対しアンケートを実施した。結果、実施されたプログラムの映像の鮮明さ(96%、104/108)、映像の動き(91%、98/108)、音声品質(83%、90/108)で肯定的な回答が得られ、医師のみを対象としたプログラム自体のアンケート結果では肯定的な回答が100%(92/92)であった。一方で音声品質については医師がネットワークエンジニアに比べて否定的に評価していた(p=0.0151)。また遠隔会議の技術的準備への労力に対する言及、音声やネットワーク、表示される映像に問題が発生した旨の報告が確認された。接続担当者にとって負担の少ない準備と、参加者にとっての品質の両方を考慮に入れることで、持続可能かつ教育的意義の高い実践的な遠隔会議となると考えられる。(著者抄録)
日本人初の多発性硬化症の包括的環境因子調査欧米白人と共通する因子とユニークな因子

迫田礼子, 松下拓也, 中村優理, 渡邉充, 篠田紘司, 磯部紀子, 吉良潤一

神経免疫学 23 ( 1 ) 128 - 128 2018.9

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A comparison of brain magnetic resonance imaging lesions in multiple sclerosis by race with reference to disability progression. Reviewed International journal

Yuri Nakamura, Laura Gaetano, Takuya Matsushita, Altermatt Anna, Till Sprenger, Ernst-Wilhelm Radue, Jens Wuerfel, Lorena Bauer, Michael Amann, Koji Shinoda, Noriko Isobe, Ryo Yamasaki, Takahiko Saida, Ludwig Kappos, Jun-Ichi Kira

Journal of neuroinflammation 15 ( 1 ) 255 - 255 2018.9

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DOI： 10.1186/s12974-018-1295-1
MS/NMO 多発性硬化症におけるT細胞受容体β鎖CDR3中心部のユニークなアミノ酸配列の存在

林史恵, 磯部紀子, 中村優理, 松下拓也, 吉良潤一

神経免疫学 23 ( 1 ) 91 - 91 2018.9

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MS/NMO 片親起源効果を用いた新規多発性硬化症リスク遺伝子の探索

磯部紀子, Tsai Andy, Caillier Stacy J., Santaniello Adam, 松下拓也, 吉良潤一, Hauser Stephen L., Oksenberg Jorge R.

神経免疫学 23 ( 1 ) 106 - 106 2018.9

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MS/NMO 血清GFAPとニューロフィラメント軽鎖は視神経脊髄炎関連疾患や多発性硬化症の障害度や再発率と相関する

渡邉充, 中村優理, Michalak Zuzanna, 林史恵, Barro Christian, 磯部紀子, 松下拓也, 山崎亮, Kuhle Jens, 吉良潤一

神経免疫学 23 ( 1 ) 92 - 92 2018.9

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多発性硬化症関連遺伝子が集積する細胞組織特異的発現調整ネットワーク解析日本人ではNK細胞が寄与する

松下拓也, 山本健, 中村優理, 渡邉充, 篠田紘司, 磯部紀子, 吉良潤一, 日本多発性硬化症遺伝コンソーシアム

神経免疫学 23 ( 1 ) 115 - 115 2018.9

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Oral phase dysphagia in facial onset sensory and motor neuronopathy. Reviewed International journal

Mitsuru Watanabe, Wataru Shiraishi, Ryo Yamasaki, Noriko Isobe, Motohiro Sawatsubashi, Ryuji Yasumatsu, Takashi Nakagawa, Jun-Ichi Kira

Brain and behavior 8 ( 6 ) e00999 2018.6

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DOI： 10.1002/brb3.999
Association of Decreased Percentage of Vδ2+Vγ9+ γδ T Cells With Disease Severity in Multiple Sclerosis

9 2018.4

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We recently reported that deletion-type copy number variations of the T cell receptor (TCR)gamma, alpha, and delta genes greatly enhanced susceptibility to multiple sclerosis (MS). However, the effect of abnormal TCR gamma delta gene rearrangement on MS pathogenesis remains unknown. In the present study, we aimed to clarify gamma delta TCR repertoire alterations and their relationship to clinical and immunological parameters in MS patients by comprehensive flow cytometric immunophenotyping. Peripheral blood mononuclear cells obtained from 30 untreated MS patients in remission and 23 age- and sex-matched healthy controls (HCs) were stained for surface markers and intracellular cytokines after stimulation with phorbol 12-myristate 13-acetate and ionomycin, and analyzed by flow cytometry. MS patients showed significantly decreased percentages of V delta 2(+) and V delta 2(+) V gamma 9(+) cells in gamma delta T cells (p(corr) = 0.0297 and p(corr) = 0.0288, respectively) and elevated V delta 1/ V delta 2 ratios compared with HCs (p = 0.0033). The percentages of interferon (IFN)-gamma V+delta 2(+) and interleukin (IL)-17A(+)IFN-gamma(+) V delta 2(+) cells in gamma delta T cells, as well as IFN-gamma(+) cells in V delta 2(+) gamma delta T cells, were significantly lower in MS patients than in HCs (p(corr) < 0.0009, p(corr) = 0.0135, and p(corr) = 0.0054, respectively). The percentages of V delta 2(+) and V delta 2(+) V gamma 9(+) cells in gamma delta T cells were negatively correlated with both the Expanded Disability Status Scale score (r = -0.5006, p = 0.0048; and r = -0.5040, p = 0.0045, respectively) and Multiple Sclerosis Severity Score (r = -0.4682, p = 0.0091; and r = -0.4706, p = 0.0087, respectively), but not with age at disease onset, disease duration, or annualized relapse rate. In HCs, the percentages of V delta 2(+) and V delta 2(+) V gamma 9(+) cells of total CD3(+) T cells had strong positive correlations with the percentage of CD25(+)CD127(low/-) cells in CD4(+) T cells (r = 0.7826, p < 0.0001; and r = 0.7848, p < 0.0001, respectively), whereas such correlations were totally absent in MS patients. These findings suggest that decreased V delta 2(+)V gamma 9(+) gamma delta T cells are associated with disability in MS. Therefore, the V delta 1/V delta 2 ratio might be a candidate biomarker for predicting disease severity in MS.

DOI： 10.3389/fimmu.2018.00748
Association of Decreased Percentage of Vδ2+Vγ9+ γδ T Cells With Disease Severity in Multiple Sclerosis

9 2018.4

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DOI： 10.3389/fimmu.2018.00748
Aberrant STAT phosphorylation signaling in peripheral blood mononuclear cells from multiple sclerosis patients. Reviewed International journal

Ester Canto, Noriko Isobe, Alessandro Didonna, Stephen L Hauser, Jorge R Oksenberg

Journal of neuroinflammation 15 ( 1 ) 72 - 72 2018.3

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DOI： 10.1186/s12974-018-1105-9
Aberrant STAT phosphorylation signaling in peripheral blood mononuclear cells from multiple sclerosis patients. Reviewed International journal

Ester Canto, Noriko Isobe, Alessandro Didonna, Stephen L Hauser, Jorge R Oksenberg

Journal of neuroinflammation 15 ( 1 ) 72 - 72 2018.3

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DOI： 10.1186/s12974-018-1105-9
パスウェイバーデン解析による多発性硬化症リスク遺伝子の疾患多様性への寄与の検討

磯部紀子

神経免疫学 22 ( 1 ) 88 - 88 2017.10

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MS・NMO2 多発性硬化症患者におけるT細胞受容体レパトアの解析

林史恵, 磯部紀子, Guzailiayi Maimaitijiang, 中村優理, 篠田絋司, 松下拓也, 吉良潤一

神経免疫学 22 ( 1 ) 114 - 114 2017.10

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【NMOとMSの最新情報】MS(multiple sclerosis)とCIS(clinically isolated syndrome)の最新の診断基準

磯部紀子, 吉良潤一

脊椎脊髄ジャーナル 30 ( 8 ) 743 - 747 2017.8

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HLA Genetic Risk Burden in Multiple Sclerosis-Reply. Reviewed International journal

Noriko Isobe, Jorge R Oksenberg, Roland G Henry

JAMA neurology 73 ( 12 ) 1501 - 1502 2016.12

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DOI： 10.1001/jamaneurol.2016.4326
HLA Genetic Risk Burden in Multiple Sclerosis-Reply. Reviewed International journal

Noriko Isobe, Jorge R Oksenberg, Roland G Henry

JAMA neurology 73 ( 12 ) 1501 - 1502 2016.12

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DOI： 10.1001/jamaneurol.2016.4326
Latitude and HLA-DRB1*04:05 independently influence disease severity in Japanese multiple sclerosis: a cross-sectional study. Reviewed International journal

Yuri Nakamura, Takuya Matsushita, Shinya Sato, Masaaki Niino, Toshiyuki Fukazawa, Satoshi Yoshimura, Shin Hisahara, Noriko Isobe, Shun Shimohama, Mitsuru Watanabe, Kazuto Yoshida, Hideki Houzen, Yusei Miyazaki, Ryo Yamasaki, Seiji Kikuchi, Jun-Ichi Kira

Journal of neuroinflammation 13 ( 1 ) 239 - 239 2016.9

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DOI： 10.1186/s12974-016-0695-3
Latitude and HLA-DRB1*04:05 independently influence disease severity in Japanese multiple sclerosis: a cross-sectional study. Reviewed International journal

Yuri Nakamura, Takuya Matsushita, Shinya Sato, Masaaki Niino, Toshiyuki Fukazawa, Satoshi Yoshimura, Shin Hisahara, Noriko Isobe, Shun Shimohama, Mitsuru Watanabe, Kazuto Yoshida, Hideki Houzen, Yusei Miyazaki, Ryo Yamasaki, Seiji Kikuchi, Jun-Ichi Kira

Journal of neuroinflammation 13 ( 1 ) 239 - 239 2016.9

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DOI： 10.1186/s12974-016-0695-3
Association of HLA Genetic Risk Burden With Disease Phenotypes in Multiple Sclerosis. Reviewed International journal

JAMA neurology 73 ( 7 ) 795 - 802 2016.7

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DOI： 10.1001/jamaneurol.2016.0980
Association of HLA Genetic Risk Burden With Disease Phenotypes in Multiple Sclerosis. Reviewed International journal

JAMA neurology 73 ( 7 ) 795 - 802 2016.7

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DOI： 10.1001/jamaneurol.2016.0980
多発性硬化症の進行はChGn-1多型と関連する(Progression of multiple sclerosis is associated with ChGn-1 polymorphism)

西郷和真, 吉村怜, 泉川友美, 松下拓也, 磯部紀子, 小池敏靖, 宮本勝一, 平野牧人, 田原康玄, 三木哲郎, 北川裕之, 吉良潤一, 楠進

臨床神経学 55 ( Suppl. ) S322 - S322 2015.12

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A non-synonymous single-nucleotide polymorphism associated with multiple sclerosis risk affects the EVI5 interactome. Reviewed International journal

Alessandro Didonna, Noriko Isobe, Stacy J Caillier, Kathy H Li, Alma L Burlingame, Stephen L Hauser, Sergio E Baranzini, Nikolaos A Patsopoulos, Jorge R Oksenberg

Human molecular genetics 24 ( 24 ) 7151 - 8 2015.12

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DOI： 10.1093/hmg/ddv412
A non-synonymous single-nucleotide polymorphism associated with multiple sclerosis risk affects the EVI5 interactome. Reviewed International journal

Alessandro Didonna, Noriko Isobe, Stacy J Caillier, Kathy H Li, Alma L Burlingame, Stephen L Hauser, Sergio E Baranzini, Nikolaos A Patsopoulos, Jorge R Oksenberg

Human molecular genetics 24 ( 24 ) 7151 - 8 2015.12

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DOI： 10.1093/hmg/ddv412
Copy number variations in multiple sclerosis and neuromyelitis optica. Reviewed International journal

Shinya Sato, Ken Yamamoto, Takuya Matsushita, Noriko Isobe, Yuji Kawano, Kyoko Iinuma, Masaaki Niino, Toshiyuki Fukazawa, Yuri Nakamura, Mitsuru Watanabe, Tomomi Yonekawa, Katsuhisa Masaki, Satoshi Yoshimura, Hiroyuki Murai, Ryo Yamasaki, Jun-Ichi Kira

Annals of neurology 78 ( 5 ) 762 - 74 2015.11

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DOI： 10.1002/ana.24511
Copy number variations in multiple sclerosis and neuromyelitis optica. Reviewed International journal

Shinya Sato, Ken Yamamoto, Takuya Matsushita, Noriko Isobe, Yuji Kawano, Kyoko Iinuma, Masaaki Niino, Toshiyuki Fukazawa, Yuri Nakamura, Mitsuru Watanabe, Tomomi Yonekawa, Katsuhisa Masaki, Satoshi Yoshimura, Hiroyuki Murai, Ryo Yamasaki, Jun-Ichi Kira

Annals of neurology 78 ( 5 ) 762 - 74 2015.11

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DOI： 10.1002/ana.24511
Latitude and HLA-DRB1 alleles independently affect the emergence of cerebrospinal fluid IgG abnormality in multiple sclerosis. Reviewed International journal

Masaaki Niino, Shinya Sato, Toshiyuki Fukazawa, Satoshi Yoshimura, Shin Hisahara, Takuya Matsushita, Noriko Isobe, Kazuto Yoshida, Hideki Houzen, Yusei Miyazaki, Shun Shimohama, Seiji Kikuchi, Jun-ichi Kira

Multiple sclerosis (Houndmills, Basingstoke, England) 21 ( 9 ) 1112 - 20 2015.8

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DOI： 10.1177/1352458514560924
An ImmunoChip study of multiple sclerosis risk in African Americans. Reviewed International journal

Brain : a journal of neurology 138 ( Pt 6 ) 1518 - 30 2015.6

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DOI： 10.1093/brain/awv078
An ImmunoChip study of multiple sclerosis risk in African Americans. Reviewed International journal

Brain : a journal of neurology 138 ( Pt 6 ) 1518 - 30 2015.6

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DOI： 10.1093/brain/awv078
Distinct features of immunoglobulin G2 aquaporin-4 antibody carriers with neuromyelitis optica Reviewed

Noriko Isobe, Tomomi Yonekawa, Takuya Matsushita, Yuji Kawano, Katsuhisa Masaki, Satoshi Yoshimura, Hiroyuki Murai, Ryo Yamasaki, Jun-Ichi Kira

Clinical and Experimental Neuroimmunology 6 ( 2 ) 154 - 158 2015.5

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DOI： 10.1111/cen3.12179
Whole genome sequences of 2 octogenarians with sustained cognitive abilities. Reviewed International journal

Dorothee Nickles, Lohith Madireddy, Nihar Patel, Noriko Isobe, Bruce L Miller, Sergio E Baranzini, Joel H Kramer, Jorge R Oksenberg

Neurobiology of aging 36 ( 3 ) 1435 - 8 2015.3

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DOI： 10.1016/j.neurobiolaging.2014.11.003
Whole genome sequences of 2 octogenarians with sustained cognitive abilities. Reviewed International journal

Dorothee Nickles, Lohith Madireddy, Nihar Patel, Noriko Isobe, Bruce L Miller, Sergio E Baranzini, Joel H Kramer, Jorge R Oksenberg

Neurobiology of aging 36 ( 3 ) 1435 - 8 2015.3

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DOI： 10.1016/j.neurobiolaging.2014.11.003
多発性硬化症および視神経脊髄炎におけるT細胞受容体遺伝子領域のコピー数多型の同定

佐藤眞也, 山本健, 松下拓也, 磯部紀子, 河野祐治, 吉村怜, 飯沼今日子, 渡邉充, 米川智, 眞崎勝久, 山崎亮, 吉良潤一, the Japan Multiple Sclerosis Genetics Consortium

臨床神経学 54 ( Suppl. ) S65 - S65 2014.12

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世界初の日本人肥厚性硬膜炎全国臨床疫学調査二次調査159例の解析結果報告

米川智, 村井弘之, 宇津木聡, 松下拓也, 眞崎勝久, 磯部紀子, 山崎亮, 吉田眞理, 楠進, 坂田清美, 藤井清孝, 吉良潤一

臨床神経学 54 ( Suppl. ) S1 - S1 2014.12

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A nationwide survey of hypertrophic pachymeningitis in Japan. Reviewed International journal

Tomomi Yonekawa, Hiroyuki Murai, Satoshi Utsuki, Takuya Matsushita, Katsuhisa Masaki, Noriko Isobe, Ryo Yamasaki, Mari Yoshida, Susumu Kusunoki, Kiyomi Sakata, Kiyotaka Fujii, Jun-ichi Kira

Journal of neurology, neurosurgery, and psychiatry 85 ( 7 ) 732 - 9 2014.7

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DOI： 10.1136/jnnp-2013-306410
Oligoclonal bands and age at onset correlate with genetic risk score in multiple sclerosis. Reviewed International journal

Multiple sclerosis (Houndmills, Basingstoke, England) 20 ( 6 ) 660 - 8 2014.5

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DOI： 10.1177/1352458513506503
Genetic and infectious profiles influence cerebrospinal fluid igg abnormality in japanese multiple sclerosis patients

Yoshimura, S., Isobe, N., Matsushita, T., Masaki, K., Sato, S., Kawano, Y., Ochi, H., Kira, J.-I.

PLoS ONE 9 ( 4 ) e95367 - e95367 2014.4

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DOI： 10.1371/journal.pone.0095367.t001
Interleukin 2 receptor α chain gene polymorphisms and risks of multiple sclerosis and neuromyelitis optica in southern Japanese. Reviewed International journal

337 ( 1-2 ) 147 - 50 2014.2

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BACKGROUND: Interleukin 2 receptor α subunit (IL2RA) is a genetic risk for multiple sclerosis (MS) in Caucasians. However, the association between MS and IL2RA in Japanese idiopathic demyelinating diseases of the central nervous system has not been examined. OBJECTIVE: To determine whether IL2RA gene polymorphisms confer risks of developing MS or neuromyelitis optica (NMO) in a Japanese population. METHODS: DNA samples were obtained from 115 MS patients, 75 NMO/NMO spectrum disorder (NMOSD) patients, and 238 healthy controls. The single nucleotide polymorphisms (SNPs) rs2104286, rs12722489, and rs7090512 were genotyped by real-time PCR using TaqMan SNP genotyping assays. RESULTS: No significant associations of the three IL2RA SNPs with the development of the diseases were observed. In MS patients only, the annualized relapse rates were significantly higher for the rs2104286-TT genotype than for the non-TT (CT+CC) genotype and for the rs12722489-CC genotype than for the non-CC genotype in females (p = 0.0138 for both), but not in males. CONCLUSIONS: Although the possibility that IL2RA is a risk factor for MS development was not confirmed in this Japanese population, IL2RA gene polymorphisms were able to modify the disease activity in female MS patients, but had no influence on either susceptibility or disease phenotype in NMO/NMOSD patients.

DOI： 10.1016/j.jns.2013.11.037
A case of neuromyelitis optica harboring both anti-aquaporin-4 antibodies and a pathogenic mitochondrial DNA mutation for Leber's hereditary optic neuropathy. Reviewed International journal

Wataru Shiraishi, Shintaro Hayashi, Takashi Kamada, Noriko Isobe, Ryo Yamasaki, Hiroyuki Murai, Yasumasa Ohyagi, Jun-ichi Kira

Multiple sclerosis (Houndmills, Basingstoke, England) 20 ( 2 ) 258 - 60 2014.2

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DOI： 10.1177/1352458513513057
A case of neuromyelitis optica harboring both anti-aquaporin-4 antibodies and a pathogenic mitochondrial DNA mutation for Leber's hereditary optic neuropathy. Reviewed International journal

Wataru Shiraishi, Shintaro Hayashi, Takashi Kamada, Noriko Isobe, Ryo Yamasaki, Hiroyuki Murai, Yasumasa Ohyagi, Jun-ichi Kira

Multiple sclerosis (Houndmills, Basingstoke, England) 20 ( 2 ) 258 - 60 2014.2

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DOI： 10.1177/1352458513513057
Interleukin 2 receptor α chain gene polymorphisms and risks of multiple sclerosis and neuromyelitis optica in southern Japanese. Reviewed International journal

337 ( 1-2 ) 147 - 50 2014.2

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DOI： 10.1016/j.jns.2013.11.037
Protein kinase C-η polymorphism rs2230500 does not confer disease susceptibility to multiple sclerosis or neuromyelitis optica Reviewed

4 ( 3 ) 283 - 287 2013.12

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Objectives To determine whether the non-synonymous 1425G/A polymorphism (rs2230500), an Asian-specific single nucleotide polymorphism that increases the kinase activity and affects the function of immune cells, of the protein kinase C-η gene (PRKCH) confers the risk of developing idiopathic demyelinating diseases of the central nervous system in a Japanese population. Methods Blood samples were collected from 96 multiple sclerosis (MS) patients, 52 neuromyelitis optica (NMO)/NMO spectrum disorder (NMOSD) patients and 151 healthy controls. The polymorphism rs2230500 was genotyped by sequencing. Results No significant association was observed between the PRKCH rs2230500 polymorphism and the risk of either MS or NMO/NMOSD. Clinical characteristics were also unaffected by the rs2230500 status. Conclusions Although the possibility that PRKCH has some effect on MS and NMO/NMOSD risk cannot be completely excluded because of the small study sample size, the polymorphism rs2230500 did not appear to confer disease susceptibility to MS or NMO/NMOSD in this Japanese population. © 2013 Japanese Society for Neuroimmunology.

DOI： 10.1111/cen3.12056
3テスラMRIによる脱髄疾患における脊髄大長病変の軸位断での病変分布と進展形式の検討

米川智, 真崎勝久, 佐藤眞也, 磯部紀子, 松下拓也, 吉良潤一

臨床神経学 53 ( 12 ) 1531 - 1531 2013.12

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IL-2受容体α鎖の遺伝子多型の日本人多発性硬化症における意義

Gulibahaer Ainiding, 河野祐治, 吉村怜, 渡邉充, 今村志穂子, 米川智, 真崎勝久, 磯部紀子, 松下拓也, 山崎亮, 吉良潤一

臨床神経学 53 ( 12 ) 1570 - 1570 2013.12

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多発性硬化症および視神経脊髄炎における全ゲノムコピー数多型解析

佐藤眞也, 山本健, 河野祐治, 松下拓也, 磯部紀子, 渡邉充, 米川智, 真崎勝久, 吉良潤一, The South Japan Multiple Sclerosis Genetics Consortium

臨床神経学 53 ( 12 ) 1594 - 1594 2013.12

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日本人多発性硬化症の緩徐進行群と非緩徐進行群の臨床・免疫遺伝学的背景の比較

渡邉充, 吉村怜, 磯部紀子, 米川智, 松下拓也, 佐藤眞也, 真崎勝久, 山崎亮, 河野祐治, 吉良潤一

臨床神経学 53 ( 12 ) 1594 - 1594 2013.12

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視神経脊髄炎におけるT細胞受容体遺伝子のコピー数多型と表現型との関連

佐藤眞也, 松下拓也, 磯部紀子, 河野祐治, 渡邉充, 米川智, 真崎勝久, 山崎亮, 山本健, 吉良潤一

神経免疫学 18 ( 1 ) 92 - 92 2013.11

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A NOTCH4 missense mutation confers resistance to multiple sclerosis in Japanese. Reviewed International journal

Jian Huang, Satoshi Yoshimura, Noriko Isobe, Takuya Matsushita, Tomomi Yonekawa, Shinya Sato, Ryo Yamasaki, Jun-ichi Kira

Multiple sclerosis (Houndmills, Basingstoke, England) 19 ( 13 ) 1696 - 703 2013.11

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DOI： 10.1177/1352458513482512
A NOTCH4 missense mutation confers resistance to multiple sclerosis in Japanese. Reviewed International journal

Jian Huang, Satoshi Yoshimura, Noriko Isobe, Takuya Matsushita, Tomomi Yonekawa, Shinya Sato, Ryo Yamasaki, Jun-ichi Kira

Multiple sclerosis (Houndmills, Basingstoke, England) 19 ( 13 ) 1696 - 703 2013.11

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DOI： 10.1177/1352458513482512
Distinct genetic profiles between Japanese multiple sclerosis patients with and without Barkhof brain lesions Reviewed

Jian Huang, Noriko Isobe, Takuya Matsushita, Satoshi Yoshimura, Shinya Sato, Tomomi Yonekawa, Ryo Yamasaki, Hiroyuki Murai, Jun-Ichi Kira

Clinical and Experimental Neuroimmunology 4 ( 2 ) 173 - 180 2013.8

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DOI： 10.1111/cen3.12017
Alterations in chemokine receptor expressions on peripheral blood monocytes in multiple sclerosis and neuromyelitis optica Reviewed

Yi Wen Cui, Yuji Kawano, Nan Shi, Katsuhisa Masaki, Noriko Isobe, Tomomi Yonekawa, Takuya Matsushita, Takahisa Tateishi, Ryo Yamasaki, Hiroyuki Murai, Jun-Ichi Kira

Clinical and Experimental Neuroimmunology 4 ( 2 ) 201 - 205 2013.8

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DOI： 10.1111/cen3.12039
Genetic risk variants in African Americans with multiple sclerosis. Reviewed International journal

Noriko Isobe, Pierre-Antoine Gourraud, Hanne F Harbo, Stacy J Caillier, Adam Santaniello, Pouya Khankhanian, Martin Maiers, Stephen Spellman, Nezih Cereb, SooYoung Yang, Marcelo J Pando, Laura Piccio, Anne H Cross, Philip L De Jager, Bruce A C Cree, Stephen L Hauser, Jorge R Oksenberg

Neurology 81 ( 3 ) 219 - 27 2013.7

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DOI： 10.1212/WNL.0b013e31829bfe2f
Clinical relevance of serum aquaporin-4 antibody levels in neuromyelitis optica. Reviewed International journal

Noriko Isobe, Tomomi Yonekawa, Takuya Matsushita, Katsuhisa Masaki, Satoshi Yoshimura, Jakub Fichna, Shu Chen, Jadwiga Furmaniak, Bernard Rees Smith, Jun-Ichi Kira

Neurochemical research 38 ( 5 ) 997 - 1001 2013.5

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DOI： 10.1007/s11064-013-1009-0
Characteristic Cerebrospinal Fluid Cytokine/Chemokine Profiles in Neuromyelitis Optica, Relapsing Remitting or Primary Progressive Multiple Sclerosis

Matsushita, T., Tateishi, T., Isobe, N., Yonekawa, T., Yamasaki, R., Matsuse, D., Murai, H., Kira, J.-I.

PLoS ONE 8 ( 4 ) e61835 - e61835 2013.4

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DOI： 10.1371/journal.pone.0061835
Distinct genetic and infectious profiles in Japanese neuromyelitis optica patients according to anti-aquaporin 4 antibody status. Reviewed International journal

Satoshi Yoshimura, Noriko Isobe, Takuya Matsushita, Tomomi Yonekawa, Katsuhisa Masaki, Shinya Sato, Yuji Kawano, Jun-ichi Kira

Journal of neurology, neurosurgery, and psychiatry 84 ( 1 ) 29 - 34 2013.1

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DOI： 10.1136/jnnp-2012-302925
日本人脱髄性疾患に影響する遺伝的要因と環境中の普遍的な感染性要因の同定

吉村怜, 磯部紀子, 米川智, 佐藤眞也, 真崎勝久, 松下拓也, 吉良潤一

臨床神経学 52 ( 12 ) 1551 - 1551 2012.12

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多発性硬化症、視神経脊髄炎、Balo病における広汎なコネキシン脱落と病態への関与

真崎勝久, 鈴木諭, 松下拓也, 松岡健, 米川智, 磯部紀子, 田平武, 岩城徹, 吉良潤一

臨床神経学 52 ( 12 ) 1552 - 1552 2012.12

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日本人アトピー性脊髄炎患者のヒト白血球抗原における疾患感受性遺伝子の探索

佐藤眞也, 米川智, 眞崎勝久, 金森祐治, 吉村怜, 磯部紀子, 松下拓也, 吉良潤一

臨床神経学 52 ( 12 ) 1402 - 1402 2012.12

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日本人多発性硬化症におけるNOTCH4ミスセンス変異とHLA Class2との相互作用

黄堅, 吉村怜, 磯部紀子, 松下拓也, 米川智, 吉良潤一

臨床神経学 52 ( 12 ) 1551 - 1551 2012.12

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Quantitative assays for anti-aquaporin-4 antibody with subclass analysis in neuromyelitis optica. Reviewed International journal

Noriko Isobe, Tomomi Yonekawa, Takuya Matsushita, Yuji Kawano, Katsuhisa Masaki, Satoshi Yoshimura, Jakub Fichna, Shu Chen, Jadwiga Furmaniak, Bernard Rees Smith, Jun-ichi Kira

Multiple sclerosis (Houndmills, Basingstoke, England) 18 ( 11 ) 1541 - 51 2012.11

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DOI： 10.1177/1352458512443917
HLA-DPB1*0201 is associated with susceptibility to atopic myelitis in Japanese. Reviewed International journal

Shinya Sato, Noriko Isobe, Satoshi Yoshimura, Yuji Kanamori, Katsuhisa Masaki, Takuya Matsushita, Jun-Ichi Kira

Journal of neuroimmunology 251 ( 1-2 ) 110 - 3 2012.10

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DOI： 10.1016/j.jneuroim.2012.07.007
多発性硬化症、視神経脊髄炎、アトピー性脊髄炎のHLA遺伝子多型の差異

佐藤眞也, 吉村怜, 米川智, 磯部紀子, 金森祐治, 眞崎勝久, 松下拓也, 吉良潤一

日本神経免疫学会学術集会抄録集 24回 99 - 99 2012.9

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MS 日本人多発性硬化症でも髄液IgG産生異常は、HLA-DRB1*1501とBarkhof基準を満たす脳MRI病巣に有意に相関する

吉村怜, 磯部紀子, 米川智, 佐藤眞也, 眞崎勝久, 松下拓也, 吉良潤一

日本神経免疫学会学術集会抄録集 24回 81 - 81 2012.9

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疾患関連遺伝子日本人脱髄性疾患の疾患関連遺伝子

吉村怜, 磯部紀子, 松下拓也, 吉良潤一

日本臨床免疫学会会誌 35 ( 4 ) 299 - 299 2012.8

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Extensive loss of connexins in Baló's disease: evidence for an auto-antibody-independent astrocytopathy via impaired astrocyte-oligodendrocyte/myelin interaction. Reviewed International journal

123 ( 6 ) 887 - 900 2012.6

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Extensive aquaporin-4 (AQP4) loss without perivascular deposition of either activated complement or immunoglobulins is a characteristic of Baló's disease. Our aim in this study was to investigate the relationship between astrocytopathy and demyelination in Baló's disease, focusing on connexins (Cx), which form gap junctions among glial cells and myelin. Autopsied specimens from four cases that provided seven actively demyelinating concentric lesions infiltrated with numerous CD68(+) macrophages were immunohistochemically examined for the astrocyte markers glial fibrillary acidic protein (GFAP), AQP4, Cx43, Cx30 and megalencephalic leukoencephalopathy with subcortical cyst 1 (MLC1). Specimens were also stained for oligodendrocyte/myelin markers, namely Cx32, Cx47, myelin-associated glycoprotein (MAG), myelin oligodendrocyte glycoprotein (MOG), oligodendrocyte-specific protein (OSP) and Nogo-A. Serum samples from six patients that had undergone magnetic resonance imaging, confirming a diagnosis of Baló's disease, were assayed for the presence of anti-Cx43, -Cx32 and -AQP4 antibodies. Despite the presence of numerous GFAP- and MLC1-positive astrocytes, there was a marked decrease in the levels of Cx43, Cx32 and Cx47. At the leading edges, Cx43 and AQP4 were mostly absent despite positive GFAP, MLC1, Cx32, Cx47, MOG, MAG, and OSP immunoreactivity. Of the six Baló's disease patients, none were positive for anti-Cxs or -AQP4 antibodies. Baló's disease is characterized by extensive loss of Cxs and AQP4, and a lack of auto-antibodies to Cxs and AQP4. Loss of Cx43 and AQP4 in the presence of other oligodendrocyte/myelin proteins at the leading edges suggests the possibility that auto-antibody-independent astrocytopathy may contribute to disease pathology via the disruption of astrocyte-oligodendrocyte/myelin interactions.

DOI： 10.1007/s00401-012-0972-x
Comparison of clinical, immunological and neuroimaging features between anti-aquaporin-4 antibody-positive and antibody-negative Sjogren's syndrome patients with central nervous system manifestations. Reviewed International journal

Riwanti Estiasari, Takuya Matsushita, Katsuhisa Masaki, Takuya Akiyama, Tomomi Yonekawa, Noriko Isobe, Jun-ichi Kira

Multiple sclerosis (Houndmills, Basingstoke, England) 18 ( 6 ) 807 - 16 2012.6

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DOI： 10.1177/1352458511431727
First diagnostic criteria for atopic myelitis with special reference to discrimination from myelitis-onset multiple sclerosis. Reviewed International journal

Noriko Isobe, Yuji Kanamori, Tomomi Yonekawa, Takuya Matsushita, Hiroshi Shigeto, Nobutoshi Kawamura, Jun-ichi Kira

Journal of the neurological sciences 316 ( 1-2 ) 30 - 5 2012.5

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DOI： 10.1016/j.jns.2012.02.007
Clinical disability progression and platelet GP IIb/IIIa values in patients with atopic myelitis. Reviewed International journal

Gulibahaer Ainiding, Ken-ichiro Yamashita, Takako Torii, Konosuke Furuta, Noriko Isobe, Takuya Matsushita, Katsuhisa Masaki, Shoji Matsumoto, Jun-ichi Kira

Journal of neuroimmunology 246 ( 1-2 ) 108 - 12 2012.5

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DOI： 10.1016/j.jneuroim.2012.03.009
First diagnostic criteria for atopic myelitis with special reference to discrimination from myelitis-onset multiple sclerosis. Reviewed International journal

Noriko Isobe, Yuji Kanamori, Tomomi Yonekawa, Takuya Matsushita, Hiroshi Shigeto, Nobutoshi Kawamura, Jun-ichi Kira

Journal of the neurological sciences 316 ( 1-2 ) 30 - 5 2012.5

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DOI： 10.1016/j.jns.2012.02.007
Distinct Genetic and Infectious Profiles between Multiple Sclerosis and Neuromyelitis Optica in Japanese Patients

Satoshi Yoshimura, Tomomi Yonekawa, Noriko Isobe, Katsuhisa Masaki, Shinya Satou, Takuya Matsushita, Jun-ichi Kira

NEUROLOGY 78 2012.4

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日本人多発性硬化症の遺伝的要因と環境要因の相互作用

吉村怜, 米川智, 磯部紀子, 眞崎勝久, 佐藤眞也, 松下拓也, 吉良潤一

日本内科学会雑誌 101 ( Suppl. ) 263 - 263 2012.2

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視神経脊髄炎(NMO)における抗アクアポリン4(AQP4)I抗体の新しい定量的測定法の検討

米川智, 真崎勝久, 磯部紀子, 松下拓也, 吉良潤一, Shu Chen, Smith Bernard, Furmaniak Jadwiga

臨床神経学 51 ( 12 ) 1313 - 1313 2011.12

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Balo病における抗AQP4抗体非依存性コネキシンアストロサイトパチー

真崎勝久, 鈴木諭, 松岡健, 米川智, 磯部紀子, 松下拓也, 岩城徹, 吉良潤一

臨床神経学 51 ( 12 ) 1370 - 1370 2011.12

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日本人多発性硬化症(MS)患者におけるinterleukin-7 receptor alpha(IL-7RA)遺伝子多型の影響とHLAとの相互作用

吉村怜, 方楽, 磯部紀子, 米川智, 松下拓也, 真崎勝久, 土井光, 吉良潤一

臨床神経学 51 ( 12 ) 1314 - 1314 2011.12

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SNP-based analysis of the HLA locus in Japanese multiple sclerosis patients

J. P. McElroy, N. Isobe, P. A. Gourraud, S. J. Caillier, T. Matsushita, T. Kohriyama, K. Miyamoto, Y. Nakatsuji, T. Miki, S. L. Hauser, J. R. Oksenberg, J. Kira

Genes and Immunity 12 ( 7 ) 523 - 530 2011.10

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DOI： 10.1038/gene.2011.25
Common and Distinct Associations of HLA-DRB1 and-DPB1 Alleles with Neuromyelitis Optica and Multiple Sclerosis in Japanese

Satoshi Yoshimura, Noriko Isobe, Takuya Matsushita, Tomomi Yonekawa, Katsuhisa Masaki, Jun-ichi Kira

ANNALS OF NEUROLOGY 70 S45 - S46 2011.10

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視神経脊髄炎における抗アクアポリン4抗体によるHLAクラスIIアリル頻度の差異および多発性硬化症との比較

松下拓也, 吉村怜, 磯部紀子, 米川智, 眞崎勝久, 吉良潤一, South Japan MS Genetic Consortium

日本神経免疫学会学術集会抄録集 23回 111 - 111 2011.9

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IL-7受容体α鎖(IL-7RA)遺伝子多型はHLA-DRB1*0405と相互作用する場合にのみMSの疾患感受性を高める

吉村怜, 磯部紀子, 松下拓也, 方楽, 米川智, 真崎勝久, 吉良潤一

日本神経免疫学会学術集会抄録集 23回 108 - 108 2011.9

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MS 多発性硬化症、視神経脊髄炎、Balo病におけるコネキシンアストロサイトパチー

真崎勝久, 鈴木諭, 松岡健, 米川智, 磯部紀子, 松下拓也, 田平武, 岩城徹, 吉良潤一

日本神経免疫学会学術集会抄録集 23回 82 - 82 2011.9

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NMO-1 抗アクアポリン4(AQP4)抗体IgG2サブクラス陽性者の臨床的特徴

磯部紀子, 米川智, 松下拓也, 河野祐治, 眞崎勝久, 吉村怜, 吉良潤一

日本神経免疫学会学術集会抄録集 23回 88 - 88 2011.9

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NMO-2 多発性硬化症・視神経脊髄炎における髄液サイトカイン・ケモカイン動態

松下拓也, 立石貴久, 米川智, 磯部紀子, 吉良潤一

日本神経免疫学会学術集会抄録集 23回 90 - 90 2011.9

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Notch4ミスセンス変異は日本人で多発性硬化症への疾患抵抗性を付与する

黄堅, 磯部紀子, 吉村怜, 松下拓也, 米川智, McElroy Joseph P., Hauser Stephen L., Oksenberg Jorge R., 吉良潤一

日本神経免疫学会学術集会抄録集 23回 109 - 109 2011.9

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アトピー性脊髄炎におけるGP IIb/IIIa依存性血小板機能の検討

アイニディン・グリバハル, 山下謙一郎, 鳥居孝子, 古田興之介, 磯部紀子, 松下拓也, 吉良潤一

日本神経免疫学会学術集会抄録集 23回 106 - 106 2011.9

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アトピー性脊髄炎と多発性硬化症の誘発電位検査所見の比較

金森祐治, 磯部紀子, 米川智, 松下拓也, 重藤寛史, 河村信利, 飛松省三, 吉良潤一

日本神経免疫学会学術集会抄録集 23回 109 - 109 2011.9

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免疫が関与する神経疾患脊髄初発多発性硬化症との比較に基づくアトピー性脊髄炎新診断基準の作成と検証

磯部紀子, 金森祐治, 米川智, 松下拓也, 重藤寛史, 河村信利, 吉良潤一

日本神経免疫学会学術集会抄録集 23回 78 - 78 2011.9

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日本人多発性硬化症(MS)患者の増加は軽症のHLA-DRB1*0405アリル保有MS患者の増加による

吉村怜, 磯部紀子, 松下拓也, 米川智, 真崎勝久, 吉良潤一

日本神経免疫学会学術集会抄録集 23回 108 - 108 2011.9

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視神経脊髄炎(NMO)と多発性硬化症(MS)における長大な脊髄病巣の3テスラMRIによる解析

米川智, 真崎勝久, 磯部紀子, 吉村怜, 松下拓也, 吉良潤一

日本神経免疫学会学術集会抄録集 23回 118 - 118 2011.9

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Wall-eyed bilateral internuclear ophthalmoplegia (WEBINO) syndrome in a patient with neuromyelitis optica spectrum disorder and anti-aquaporin-4 antibody. Reviewed International journal

Koji Shinoda, Takuya Matsushita, Konosuke Furuta, Noriko Isobe, Tomomi Yonekawa, Yasumasa Ohyagi, Jun-ichi Kira

Multiple sclerosis (Houndmills, Basingstoke, England) 17 ( 7 ) 885 - 7 2011.7

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DOI： 10.1177/1352458510391690
T cell reactivities to myelin protein-derived peptides in neuromyelitis optica patients with anti-aquaporin-4 antibody Reviewed

Tomomi Yonekawa, Takuya Matsushita, Motozumi Minohara, Noriko Isobe, Katsuhisa Masaki, Satoshi Yoshimura, Yasuharu Nishimura, Jun-ichi Kira

NEUROLOGY ASIA 16 ( 2 ) 139 - 142 2011.6

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Characteristics of myasthenia gravis according to onset-age: Japanese nationwide survey. Reviewed International journal

Hiroyuki Murai, Natsumi Yamashita, Makoto Watanabe, Yoshiko Nomura, Masakatsu Motomura, Hiroaki Yoshikawa, Yosikazu Nakamura, Naoki Kawaguchi, Hiroshi Onodera, Shigeru Araga, Noriko Isobe, Masaki Nagai, Jun-ichi Kira

Journal of the neurological sciences 305 ( 1-2 ) 97 - 102 2011.6

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DOI： 10.1016/j.jns.2011.03.004
Interleukin-7 receptor alpha gene polymorphism influences multiple sclerosis risk in Asians

L. Fang, N. Isobe, S. Yoshimura, T. Yonekawa, T. Matsushita, K. Masaki, H. Doi, K. Ochi, K. Miyamoto, Y. Kawano, J. Kira

Neurology 76 ( 24 ) 2125 - 2127 2011.6

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DOI： 10.1212/WNL.0b013e31821f466c
Analysis of cerebrospinal fluid cytokines and growth factors in multiple sclerosis patients with and without chronic headaches Reviewed

Hikaru Doi, Takuya Matsushita, Noriko Isobe, Takahisa Tateishi, Jun-ichi Kira

NEUROLOGY ASIA 16 ( 1 ) 65 - 70 2011.3

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頭部病巣の有無による再発寛解型視神経脊髄炎の臨床的特徴の比較

松下拓也, 磯部紀子, 松岡健, 真崎勝久, 米川智, 吉良潤一

臨床神経学 50 ( 12 ) 1155 - 1155 2010.12

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MSおよびNMOにおける脳脊髄液中サイトカイン解析およびインターフェロンβによる影響

土井光, 松下拓也, 立石貴久, 磯部紀子, 吉良潤一

臨床神経学 50 ( 12 ) 1277 - 1277 2010.12

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Non-NMO MSとNMOにおけるHLA-DRB1アリル間のepistatic interaction解析

磯部紀子, 松下拓也, 松岡健, 米川智, 真崎勝久, Ramagopalan Sv, Ebers Gc, 西村泰治, 吉良潤一

臨床神経学 50 ( 12 ) 1155 - 1155 2010.12

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【MS(多発性硬化症)とNMO(視神経脊髄炎)】日本のMS、NMOの疫学的特徴全国臨床疫学調査の解析結果から

磯部紀子, 吉良潤一

22 ( 4 ) 303 - 310 2010.12

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わが国において、これまで4回にわたり多発性硬化症についての全国臨床疫学調査が行われ、その特徴が明らかになった。すなわち、(1)有病率が増加傾向にある、(2)発症年齢のピークが若年化している、(3)アジア型とされる視神経脊髄型の占める割合が徐々に減少し、欧米型(通常型)の割合が高くなっている、(4)特に緯度との関係では北に行くほど欧米型が占める割合が多い、という特徴があった。多発性硬化症は、遺伝的要因と環境要因の両者が関与する多因子疾患であるが、経時的な臨床疫学調査の結果により、環境因子の変化によると思われる臨床像の変化、臨床病型の変遷が示された。(著者抄録)
アクアポリン4 M1、M23各イソフォームに対するNMO及びMS患者血清の反応性の検討

米川智, 磯部紀子, 真崎勝久, 松下拓也, 吉良潤一

臨床神経学 50 ( 12 ) 1140 - 1140 2010.12

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脱髄疾患におけるCLDND1の病理学的検討

真崎勝久, 三野原元澄, 米川智, 磯部紀子, 松下拓也, 吉良潤一

臨床神経学 50 ( 12 ) 1213 - 1213 2010.12

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Altered production of brain-derived neurotrophic factor by peripheral blood immune cells in multiple sclerosis. Reviewed International journal

Satoshi Yoshimura, Hirofumi Ochi, Noriko Isobe, Takuya Matsushita, Kyoko Motomura, Takeshi Matsuoka, Motozumi Minohara, Jun-ichi Kira

Multiple sclerosis (Houndmills, Basingstoke, England) 16 ( 10 ) 1178 - 88 2010.10

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DOI： 10.1177/1352458510375706
CSF angiotensin II and angiotensin-converting enzyme levels in anti-aquaporin-4 autoimmunity Reviewed

T. Matsushita, N. Isobe, M. Kawajiri, M. Mogi, K. Tsukuda, M. Horiuchi, Y. Ohyagi, J. Kira

JOURNAL OF THE NEUROLOGICAL SCIENCES 295 ( 1-2 ) 41 - 45 2010.8

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DOI： 10.1016/j.jns.2010.05.014
臨床医のための神経病理アトピー性脊髄炎

磯部紀子, 吉良潤一

28 ( 8 ) 842 - 843 2010.8

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特発性血小板減少性紫斑病に関連した多発単神経障害の1例

中村憲道, 重藤寛史, 磯部紀子, 田中正人, 大八木保政, 吉良潤一

臨床神経学 50 ( 7 ) 482 - 484 2010.7

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症例は78歳男性。某年7月、左前腕に紫斑が出現。血小板数1.1万/μl、血小板関連自己抗体陽性であり、特発性血小板減少性紫斑病と診断された。翌月初旬より左手指および左下腿の脱力と異常感覚、両下腿外側の異常感覚が出現した。来院時所見では、左尺骨神経領域の感覚障害と筋力低下、両側浅腓骨神経領域の感覚障害、左前脛骨筋の筋力低下をみとめ多発単神経障害の病像を呈していた。ステロイド治療による血小板数の増加とともに脱力、感覚障害も改善した。特発性血小板減少性紫斑病に関連した多発単神経障害と考えられ、免疫学的機序による障害が推察された。(著者抄録)
[A case of mononeuropathy multiplex associated with idiopathic thrombocytopenic purpura]. Reviewed

Norimichi Nakamura, Hiroshi Shigeto, Noriko Isobe, Masato Tanaka, Yasumasa Ohyagi, Jun-ichi Kira

Rinsho shinkeigaku = Clinical neurology 50 ( 7 ) 482 - 4 2010.7

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孤発性片麻痺性片頭痛を呈した全身性エリテマトーデスの1例

土井光, 立石貴久, 磯部紀子, 山崎亮, 大八木保政, 吉良潤一

臨床神経学 50 ( 5 ) 332 - 334 2010.5

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症例は39歳の女性である。誘因なく左半身の異常感覚・不全片麻痺に続き視野欠損が出現し、3時間以内に消失する発作を反復性にみとめ、その発作の中で2回は嘔気をともなう左側頭部痛をともなった。頭部MR検査で明らかな異常所見なく、孤発性片麻痺性片頭痛(SHM)に合致した。また再発性の皮疹や関節痛も発作2年前よりみとめ、全身性エリテマトーデス(SLE)と診断した。くりかえす発作に対しアスピリンおよび塩酸ロメリジンの投与をおこない、その後発作はすみやかに消失した。SLEにSHMをともなうことはきわめてまれであるが、SHMの鑑別診断としてSLEも考慮する必要がある。(著者抄録)
CSF chemokine alterations related to the clinical course of amyotrophic lateral sclerosis. Reviewed International journal

Takahisa Tateishi, Ryo Yamasaki, Masahito Tanaka, Takuya Matsushita, Hitoshi Kikuchi, Noriko Isobe, Yasumasa Ohyagi, Jun-ichi Kira

Journal of neuroimmunology 222 ( 1-2 ) 76 - 81 2010.5

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DOI： 10.1016/j.jneuroim.2010.03.004
[Sporadic hemiplegic migraine-like headache in a patient with systemic lupus erythematosus]. Reviewed

Hikaru Doi, Takahisa Tateishi, Noriko Isobe, Ryo Yamasaki, Yasumasa Ohyagi, Jun-ichi Kira

Rinsho shinkeigaku = Clinical neurology 50 ( 5 ) 332 - 4 2010.5

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TTR質量分析および遺伝子検査が診断に有用であったFAP ATTR Ile107Valの1例

河村信利, 磯部紀子, 田中弘二, 大八木保政, 植田光晴, 安東由喜雄, 岩城徹, 吉良潤一

自律神経 47 ( 2 ) 171 - 171 2010.4

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Reappraisal of brain MRI features in patients with multiple sclerosis and neuromyelitis optica according to anti-aquaporin-4 antibody status. Reviewed International journal

Takuya Matsushita, Noriko Isobe, Hua Piao, Takeshi Matsuoka, Takaaki Ishizu, Hikaru Doi, Katsuhisa Masaki, Takashi Yoshiura, Ryo Yamasaki, Yasumasa Ohyagi, Jun-Ichi Kira

Journal of the neurological sciences 291 ( 1-2 ) 37 - 43 2010.4

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DOI： 10.1016/j.jns.2010.01.009
神経免疫実験モデル中枢神経系におけるCLDND1の発現と脱髄疾患への関与

真崎勝久, 三野原元澄, 米川智, 磯部紀子, 松下拓也, 吉良潤一

日本神経免疫学会学術集会抄録集 22回 49 - 49 2010.3

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Non-NMO MSとNMOにおけるHLA-DRB1アリル間のepistatic interaction解析

磯部紀子, 松下拓也, 松岡健, 米川智, 眞崎勝久, Ramagopalan SV, Ebers GC, 西村泰治, 吉良潤一

日本神経免疫学会学術集会抄録集 22回 86 - 86 2010.3

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中枢神経障害を有するシェーグレン症候群と抗aquaporin-4(AQP4)抗体

松下拓也, 眞崎勝久, 米川智, 磯部紀子, 松岡健, 吉良潤一

日本神経免疫学会学術集会抄録集 22回 90 - 90 2010.3

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多発性硬化症における抗神経軸索抗体

磯部紀子, 吉良潤一

18 ( 1 ) 10 - 11 2010.3

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Influence of HLA-DRB1 alleles on the susceptibility and resistance to multiple sclerosis in Japanese patients with respect to anti-aquaporin 4 antibody status Reviewed

N. Isobe, T. Matsushita, R. Yamasaki, S. V. Ramagopalan, Y. Kawano, Y. Nishimura, G. C. Ebers, J. Kira

MULTIPLE SCLEROSIS 16 ( 2 ) 147 - 155 2010.2

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DOI： 10.1177/1352458509355067
抗アクアポリン4抗体陽性症例の再発期における高補体血症

土井光, 松下拓也, 磯部紀子, 松岡健, 三野原元澄, 越智博文, 吉良潤一

臨床神経学 49 ( 12 ) 1130 - 1130 2009.12

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Association of anti-Helicobacter pylori neutrophil-activating protein antibody response with anti-aquaporin-4 autoimmunity in Japanese patients with multiple sclerosis and neuromyelitis optica. Reviewed International journal

Wei Li, Motozumi Minohara, Hua Piao, Takuya Matsushita, Katsuhisa Masaki, Takeshi Matsuoka, Noriko Isobe, Jen Jen Su, Yasumasa Ohyagi, Jun-ichi Kira

Multiple sclerosis (Houndmills, Basingstoke, England) 15 ( 12 ) 1411 - 21 2009.12

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DOI： 10.1177/1352458509348961
FACSの高感度化による抗AQP4抗体サブクラス解析の意義

河野祐治, 磯部紀子, 松下拓也, 松岡健, 河村信利, 三野原元澄, 吉良潤一, 三木哲郎

臨床神経学 49 ( 12 ) 1110 - 1110 2009.12

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ヘリコバクターピロリ感染による多発性硬化症の重症化

三野原元澄, 李巍, 松下拓也, 松岡健, 磯部紀子, 石津尚明, 吉良潤一

臨床神経学 49 ( 12 ) 1188 - 1188 2009.12

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多発性硬化症(MS)におけるHLA-DRB1アリル間の相互作用の検討

磯部紀子, 松下拓也, 松岡健, 河野祐治, 三野原元澄, 吉良潤一

臨床神経学 49 ( 12 ) 1187 - 1187 2009.12

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多発性硬化症及びNMOにおけるBAFF及びAPRILの解析

岡田和将, 辻貞俊, 磯部紀子, 吉良潤一

臨床神経学 49 ( 12 ) 1113 - 1113 2009.12

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抗aquaporin-4(AQP4)抗体陽性例におけるT細胞内・脳脊髄液中サイトカインの特徴

松下拓也, 磯部紀子, 松岡健, 史楠, 三野原元澄, 河野祐治, 吉良潤一

臨床神経学 49 ( 12 ) 1131 - 1131 2009.12

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Frequency of Chronic Headaches in Japanese Patients With Multiple Sclerosis: With Special Reference to Opticospinal and Common Forms of Multiple Sclerosis Reviewed

Hikaru Doi, Takuya Matsushita, Noriko Isobe, Takaaki Ishizu, Yasumasa Ohyagi, Jun-ichi Kira

HEADACHE 49 ( 10 ) 1513 - 1520 2009.11

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DOI： 10.1111/j.1526-4610.2009.01427.x
TTR質量分析および遺伝子検査が診断に有用であったFAP ATTR Ile107Valの1例

河村信利, 磯部紀子, 田中弘二, 大八木保政, 植田光晴, 安東由喜雄, 岩城徹, 吉良潤一

日本自律神経学会総会プログラム・抄録集 62回 204 - 204 2009.11

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Neural damage associated with atopic diathesis A nationwide survey in Japan Reviewed

N. Isobe, J. Kira, N. Kawamura, T. Ishizu, K. Arimura, Y. Kawano

NEUROLOGY 73 ( 10 ) 790 - 797 2009.9

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DOI： 10.1212/WNL.0b013e3181b6bb6b
Extensive vasogenic edema of anti-aquaporin-4 antibody-related brain lesions Reviewed

T. Matsushita, N. Isobe, T. Matsuoka, T. Ishizu, Y. Kawano, T. Yoshiura, Y. Ohyagi, J. Kira

MULTIPLE SCLEROSIS 15 ( 9 ) 1113 - 1117 2009.9

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DOI： 10.1177/1352458509106613
Aquaporin-4 autoimmune syndrome and anti-aquaporin-4 antibody-negative opticospinal multiple sclerosis in Japanese Reviewed

T. Matsushita, N. Isobe, T. Matsuoka, N. Shi, Y. Kawano, X. M. Wu, T. Yoshiura, Y. Nakao, T. Ishizu, J. I. Kira

MULTIPLE SCLEROSIS 15 ( 7 ) 834 - 847 2009.7

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DOI： 10.1177/1352458509104595
Multimodality-evoked potential study of anti-aquaporin-4 antibody-positive and -negative multiple sclerosis patients. Reviewed International journal

Akihiro Watanabe, Takuya Matsushita, Hikaru Doi, Takashi Matsuoka, Hiroshi Shigeto, Noriko Isobe, Yuji Kawano, Shozo Tobimatsu, Jun-ichi Kira

Journal of the neurological sciences 281 ( 1-2 ) 34 - 40 2009.6

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DOI： 10.1016/j.jns.2009.02.371
抗aquaporin-4抗体陽性の脳幹脳炎の1例

岩中行己男, 岡田和将, 魚住武則, 辻貞俊, 磯部紀子, 吉良潤一

臨床神経学 49 ( 4 ) 205 - 205 2009.4

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Hypercomplementemia at relapse in patients with anti-aquaporin-4 antibody Reviewed

H. Doi, T. Matsushita, N. Isobe, T. Matsuoka, M. Minohara, H. Ochi, J. I. Kira

MULTIPLE SCLEROSIS 15 ( 3 ) 304 - 310 2009.3

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DOI： 10.1177/1352458508099139
FACSを用いた高感度抗AQP4抗体の検出サブクラス解析を含めて

磯部紀子, 河野祐治, 松下拓也, 松岡健, 河村信利, 三野原元澄, 吉良潤一

神経免疫学 17 ( 1 ) 74 - 74 2009.3

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多発性硬化症および抗アクアポリン4抗体陽性症例における補体系の検討

土井光, 松下拓也, 磯部紀子, 松岡健, 三野原元澄, 越智博文, 吉良潤一

神経免疫学 17 ( 1 ) 52 - 52 2009.3

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多発性硬化症におけるヘリコバクターピロリ感染の影響

三野原元澄, 李巍, 松下拓也, 松岡健, 磯部紀子, 吉良潤一

神経免疫学 17 ( 1 ) 150 - 150 2009.3

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抗aquaporin-4(AQP4)抗体陽性例における細胞内・脳脊髄液中サイトカインの特徴

松下拓也, 磯部紀子, 松岡健, 史楠, 三野原元澄, 河野祐治, 吉良潤一

神経免疫学 17 ( 1 ) 69 - 69 2009.3

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Association of the HLA-DPB1*0501 allele with anti-aquaporin-4 antibody positivity in Japanese patients with idiopathic central nervous system demyelinating disorders Reviewed

T. Matsushita, T. Matsuoka, N. Isobe, Y. Kawano, M. Minohara, N. Shi, Y. Nishimura, H. Ochi, J. Kira

TISSUE ANTIGENS 73 ( 2 ) 171 - 176 2009.2

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DOI： 10.1111/j.1399-0039.2008.01172.x
Opticospinal multiple sclerosis in Japanese Reviewed

Jun-ichi Kira, Takuya Matsushita, Noriko Isobe, Takaaki Ishizu

NEUROLOGY ASIA 13 167 - 173 2008.12

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mdxマウスにおけるサイトカイン・ケモカインの動態解析と分子標的療法の開発

荒畑創, 田中正人, 立石貴久, 磯部紀子, 本村今日子, 大八木保政, 吉良潤一

臨床神経学 48 ( 12 ) 1173 - 1173 2008.12

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アトピー関連末梢神経炎・脊髄炎の全国臨床疫学調査結果

磯部紀子, 河野祐治, 河村信利, 三野原元澄, 吉良潤一

末梢神経 19 ( 2 ) 350 - 352 2008.12

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アトピー関連脊髄炎・末梢神経炎の全国臨床疫学調査結果

磯部紀子, 河野祐治, 河村信利, 三野原元澄, 吉良潤一

臨床神経学 48 ( 12 ) 1047 - 1047 2008.12

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腎移植後にHTLV-1関連脊髄症(HAM)を発症し、特異な脳MRI所見を認めた一例

磯部紀子, 西口明子, 金ミエ, 立石貴久, 越智博文, 大八木保政, 吉良潤一

13 ( 2 ) 92 - 92 2008.9

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Acute onset facial numbness. International journal

Noriko Kuroki, Yasumasa Ohyagi, Yuji Kawano, Takashi Yoshiura, Takayuki Taniwaki, Jun-ichi Kira

Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 15 ( 9 ) 1049, 1077 2008.9

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【重症筋無力症-病態解明と診療の進歩】治療ガイドライン治療全体の流れ

磯部紀子, 吉良潤一

26 ( 9 ) 1010 - 1013 2008.9

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Atopic myelitis with focal amyotrophy: a possible link to Hopkins syndrome. Reviewed International journal

Jun-Ichi Kira, Noriko Isobe, Yuji Kawano, Manabu Osoegawa, Yasumasa Ohyagi, Futoshi Mihara, Hiroyuki Murai

Journal of the neurological sciences 269 ( 1-2 ) 143 - 51 2008.6

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DOI： 10.1016/j.jns.2008.01.009
基礎疾患なく雷鳴頭痛とposterior reversible encephalopathy syndrome(PRES)を発症し、経過中可逆性の脳血管攣縮をみとめた1例

古賀優子, 磯部紀子[黒木], 立石貴久, 小副川学, 大八木保政, 吉良潤一

臨床神経学 48 ( 5 ) 355 - 358 2008.5

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症例は56歳女性である。雷鳴頭痛を主訴に当院へ救急搬送されるも、頭部CT、髄液検査で異常なく帰宅した。しかし数日後、ふたたび雷鳴頭痛が出現し当院へ搬送され、来院時左下肢の痙攣をみとめた。MRIにて両側後頭葉を中心にADC値上昇をともなうT2延長領域をみとめ、posterior reversible encephalopathy syndrome(PRES)と診断した。高血圧や免疫抑制剤の使用歴はなかった。MRAにて両側後大脳動脈を中心に脳血管攣縮をみとめたため、Ca拮抗薬を投与し、約2週間でMRI所見と共にMRA所見も改善し、ほぼ後遺症なく回復した。雷鳴頭痛およびPRESの発症に、脳血管攣縮が強く関与していることが示唆された。(著者抄録)
[Case of posterior reversible encephalopathy syndrome with cerebral vasoconstriction]. Reviewed

Yuko Koga, Noriko Isobe, Takahisa Tateishi, Manabu Osoegawa, Yasumasa Ohyagi, Jun-ichi Kira

Rinsho shinkeigaku = Clinical neurology 48 ( 5 ) 355 - 8 2008.5

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脳炎、筋炎、その他アトピー関連脊髄炎・末梢神経炎の全国臨床疫学調査成績

磯部紀子, 河野祐治, 河村信利, 三野原元澄, 吉良潤一

神経免疫学 16 ( 1 ) 119 - 119 2008.4

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腎移植後にHTLV-1関連脊髄症(HAM)を発症し、特異な脳MRI所見を認め、薬剤性脳症の合併が疑われた1例

磯部紀子[黒木], 金ミエ, 立石貴久, 小副川学, 大八木保政, 吉良潤一

臨床神経学 48 ( 3 ) 222 - 222 2008.3

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急性散在性脳脊髄炎後の低酸素脳症によりparoxysmal sympathetic stormを来した一例

石津尚明, 黒木紀子, 松瀬大, 重藤寛史, 小副川学, 村井弘之, 大八木保政, 吉良潤一

臨床神経学 47 ( 9 ) 622 - 622 2007.9

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当院におけるrt-PAを用いた超急性期脳梗塞治療の検討

福永真実, 黒木紀子, 山崎賢智

脳卒中 29 ( 2 ) 316 - 316 2007.3

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統合失調症様症状で発症した非ヘルペス性辺縁系脳炎の一例

黒木紀子, 福永真実, 岩田智則, 松本俊一, 山崎賢智

臨床神経学 46 ( 6 ) 446 - 446 2006.6

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脳内空気塞栓症の2例

山崎賢智, 福永真実, 黒木紀子, 岩田智則

脳卒中 28 ( 1 ) 231 - 231 2006.3

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脳梗塞で発症した急性大動脈解離の3例

黒木紀子, 福永真実, 岩田智則, 松本俊一, 山崎賢智

脳卒中 28 ( 1 ) 164 - 164 2006.3

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ネフローゼ症候群に生じた上矢状静脈洞血栓症の1例

黒木紀子, 吉村怜, 福永真実, 岩田智則, 松本俊一, 山崎賢智

臨床神経学 46 ( 1 ) 92 - 92 2006.1

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脳梗塞にて発症した急性大動脈解離の1例

黒木紀子, 福永真実, 岩田智則, 松本俊一, 山崎賢智

臨床神経学 45 ( 8 ) 613 - 613 2005.8

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眼で見る神経内科 CAGリピート延長著明な若年発症型Huntington病におけるMRI・SPECT画像

黒木紀子, 大八木保政, 本村今日子, 谷脇考恭, 吉良潤一

神経内科 62 ( 6 ) 610 - 612 2005.6

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Presentations

ようこそ神経免疫へ！.

磯部紀子

2023.12

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NMOSDの目指すべき治療ゴール.

磯部紀子

NMOSD Premium workshop To disseminate optimal NMOSD treatment from Japan NMOSD診療の up-to-date and beyond 2023.12

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ようこそ神経免疫へ！.

磯部紀子

2023.12

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NMOSDの目指すべき治療ゴール.

磯部紀子

NMOSD Premium workshop To disseminate optimal NMOSD treatment from Japan NMOSD診療の up-to-date and beyond 2023.12

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アストログリアCx43を標的とした進行型多発性硬化症に対する新規治療法開発.

高瀬オズデミルエズギ, 山崎亮, 永田諭, 渡邉充, 山口浩雄, 眞﨑勝久, 吉良潤一, 竹内英之, 磯部紀子

第51回日本臨床免疫学会総会 2023.10

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アストログリアCx43を標的とした進行型多発性硬化症に対する新規治療法開発.

高瀬オズデミルエズギ, 山崎亮, 永田諭, 渡邉充, 山口浩雄, 眞﨑勝久, 吉良潤一, 竹内英之, 磯部紀子

第51回日本臨床免疫学会総会 2023.10

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参加者と共に考える「NMOSDにおける生物学的製剤の位置づけ」.

磯部紀子

第35回日本神経免疫学会学術集会シンポジウム16・Pros & Cons. 2023年版視神経脊髄炎スペクトラム診療を考える． 2023.9

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参加者と共に考える「NMOSDにおける生物学的製剤の位置づけ」.

磯部紀子

第35回日本神経免疫学会学術集会シンポジウム16・Pros & Cons. 2023年版視神経脊髄炎スペクトラム診療を考える． 2023.9

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精神神経疾患医療への応用に向けた眼底ハイパースペクトルイメージング.

中村大輔, 上田瑛美, 渡邉充, 松瀨大, 礒部紀子, 園田康平

レーザー学会第577回研究会 2023.9

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精神神経疾患医療への応用に向けた眼底ハイパースペクトルイメージング.

中村大輔, 上田瑛美, 渡邉充, 松瀨大, 礒部紀子, 園田康平

レーザー学会第577回研究会 2023.9

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中枢神経系自己免疫性疾患の病因と治療

磯部紀子

千葉脳神経内科フォーラム 2023.7

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中枢神経系自己免疫性疾患の病因と治療

磯部紀子

千葉脳神経内科フォーラム 2023.7

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エンスプリング使用下の安全対策の実際.

磯部紀子

諏訪南信Neurological Seminar 2023.6

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エンスプリング使用下の安全対策の実際.

磯部紀子

諏訪南信Neurological Seminar 2023.6

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膠原病リウマチ医に知って頂きたい神経診察と神経疾患. Invited

磯部紀子

第67回日本リウマチ学会総会・学術集会教育研修講演 2023.4

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Language：Japanese Presentation type：Public lecture, seminar, tutorial, course, or other speech

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膠原病リウマチ医に知って頂きたい神経診察と神経疾患.

磯部紀子

第67回日本リウマチ学会総会・学術集会教育研修講演 2023.4

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膠原病リウマチ医に知って頂きたい神経診察と神経疾患.

磯部紀子

第67回日本リウマチ学会総会・学術集会教育研修講演 2023.4

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MS/NMO治療の現在.

磯部紀子

第6回神経治療研修会 2023.4

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MS/NMO治療の現在.

磯部紀子

第6回神経治療研修会 2023.4

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エンスプリング使用下の安全対策の実際.

磯部紀子

2023.4

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エンスプリング使用下の安全対策の実際.

磯部紀子

2023.4

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The Genetic of Neuroimmunology Invited

Noriko Isobe

ASIA PACIFIC School of Neuroimmunology (APSNI) 2023.2

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多発性硬化症：病初期から進行期まで途切れのない治療の必要性 Invited

磯部紀子

第33回日本神経免疫学会学術集会 2021.10

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Multiple sclerosis: strategies for future precision medicine Invited

2021.10

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Multiple sclerosis: strategies for future precision medicine
免疫介在性疾患の病因追究手段としてのHLAその他の遺伝子解析手法の原理と臨床的意義づけ Invited

磯部紀子

第32回日本神経免疫学会学術集会 2020.10

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ラブリズマブ使用時に侵襲性髄膜炎菌感染症が疑われた全身型重症筋無力症の一例

寺師綾子, 渡邉充, 佐野仁美, 田中栄蔵, 入江剛史, 山崎亮, 磯部紀子

NEUROINFECTION 2023.10 日本神経感染症学会

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上肢に運動機能障害を有する神経筋疾患患者における電子端末の利用状況調査　IT活用時の留意点を考える

小早川優子, 江千里, 橋本侑, 原田幸子, 戸高浩司, 山崎亮, 磯部紀子

日本難病医療ネットワーク学会機関誌 2023.11 日本難病医療ネットワーク学会

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中枢性コネキシンヘミチャネル阻害剤が小脳型多系統萎縮症を抑制する(A centrally acting connexin hemichannel blocker attenuates multiple system atrophy-cerebellar type)

Harada Masaya, Masaki Katsuhisa, Matsuse Dai, Yamaguchi Hiroo, Nishimura Yuji, Ozdemir Ezgi, Tanaka Eizo, Tanaka Tatsunori, Yamasaki Ryo, Takeuchi Hideyuki, Taniwaki Takayuki, Isobe Noriko, Kira Jun-ichi

臨床神経学 2023.9 (一社)日本神経学会

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免疫疾患の病態解明と治療フロンティア　中枢神経自己免疫性疾患の病態と最新の治療

磯部紀子

日本内科学会雑誌 2024.2 (一社)日本内科学会

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多発性硬化症の病因と治療戦略

磯部紀子

臨床神経学 2022.7 (一社)日本神経学会

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多系統萎縮症におけるGPR17陽性髄鞘形成前オリゴデンドロサイトの著明な発現上昇(Marked upregulation of GPR17-positive premyelinating oligodendrocytes in multiple system atrophy)

Nishimura Yuji, Masaki Katsuhisa, Matsuse Dai, Yamaguchi Hiroo, Tanaka Tatsunori, Sadashima Shoko, Sasagasako Naokazu, Yamasaki Ryo, Honda Hiroyuki, Isobe Noriko, Iwaki Toru, Kira Jun-ichi

臨床神経学 2023.9 (一社)日本神経学会

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多系統萎縮症におけるグリアコネキシンの早期かつ広範な変化(Early and extensive alterations of glial connexins in multiple system atrophy)

Masaki Katsuhisa, Nishimura Yuji, Matsuse Dai, Yamaguchi Hiroo, Tanaka Tatsunori, Sadashima Shoko, Sasagasako Naokazu, Yamasaki Ryo, Iwaki Toru, Isobe Noriko, Kira Junichi

臨床神経学 2023.9 (一社)日本神経学会

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多系統萎縮症の増悪に関連した特異的なミクログリア集団の同定(Identification of a unique microglia population exacerbating multiple system atrophy)

Matsuse Dai, Yamaguchi Hiroo, Nishimura Yuji, Masaki Katsuhisa, Tanaka Tatsunori, Saiga Toru, Harada Masaya, Tanaka Kenji, Yamasaki Ryo, Isobe Noriko, Kira Jun-ichi

臨床神経学 2023.9 (一社)日本神経学会

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定量的感覚検査による自己免疫性ノドパチーにおける小径線維の評価(Assessment of small fiber involvement in autoimmune nodopathy by quantitative sensory testing)

Fujii Takayuki, Ogata Hidenori, Yamasaki Ryo, Isobe Noriko

臨床神経学 2023.9 (一社)日本神経学会

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定量的感覚検査による自己免疫性ノドパチーにおける小径線維障害の検討

藤井敬之, 緒方英紀, 田代匠, 井ノ上有香, 山崎亮, 磯部紀子

末梢神経 2023.12 日本末梢神経学会

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小脳型多系統萎縮症モデルマウスを用いた新規創薬ターゲットの探索

山口浩雄, 西村由宇慈, 松瀬大, 眞崎勝久, 田中辰典, 雑賀徹, 原田雅也, 田中謙二, 山埼亮, 磯部紀子, 吉良潤一

神経治療学 2022.10 (一社)日本神経治療学会

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抗Annexin A2自己抗体と神経因性疼痛との関連(Anti-Annexin A2 autoantibodies relate to neuropathic pain)

Kashu Kaoru, Fujii Takayuki, Ogata Hidenori, Sato Yoshidomi, Yamasaki Ryo, Isobe Noriko

臨床神経学 2023.9 (一社)日本神経学会

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日本における顔面発症感覚運動ニューロノパチー(FOSMN)の全国疫学調査(A nationwide epidemiological survey of Facial Onset Sensory Motor Neuronopathy(FOSMN) in Japan)

Ko Senri, Yamasaki Ryo, Okui Tasuku, Shiraishi Wataru, Watanabe Mitsuru, Hashimoto Yu, Kobayakawa Yuko, Kusunoki Susumu, Kira Jun-ichi, Isobe Noriko

臨床神経学 2022.10 (一社)日本神経学会

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日本人多発性硬化症におけるHLAサブタイプとglatiramer acetateの有効性の関連性(Association between HLA subtype and efficacy of glatiramer acetate in Japanese multiple sclerosis)

Tanaka Eizo, Watanabe Mitsuru, Fukumoto Shoko, Masaki Katsuhisa, Matsushita Takuya, Isobe Noriko

臨床神経学 2022.10 (一社)日本神経学会

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日本人多発性硬化症患者において灰白質体積の少なさは認知機能低下を予測できる(Low gray matter volume can predict cognitive decline in Japanese patients with multiple sclerosis)

Fukumoto Shoko, Watanabe Mitsuru, Niino Masaaki, Masaki Katsuhisa, Matsushita Takuya, Sakoda Ayako, Hayashi Fumie, Kira Jun-ichi, Isobe Noriko

臨床神経学 2022.10 (一社)日本神経学会

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末梢性神経障害性疼痛患者における抗Annexin A2抗体の保有率および抗体陽性患者の臨床的特徴の解明

賀集薫, 藤井敬之, 緒方英紀, 吉富小都, 山崎亮, 磯部紀子

末梢神経 2023.12 日本末梢神経学会

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治療に難渋した抗neurofascin(NF)155抗体陽性ノドパチーの一例

伊波勇輝, 羽場崎由梨奈, 南澤有紀, 佐藤睦美, 本井宏尚, 渡辺好宏, 緒方英紀, 磯部紀子

脳と発達 2024.5 (一社)日本小児神経学会

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海馬の不完全な反転は焦点性てんかんの原因ではない(Incomplete hippocampal inversion is not a cause of focal epilepsy)

Mukaino Takahiko, Okadome Toshiki, Yamaguchi Takahiro, Yamada Emi, Ohta Shinri, Mitoma Ryo, Mitsudo Takako, Tamura Shunsuke, Hirano Yoji, Togao Osamu, Hagihara Koichi, Isobe Noriko, Shigeto Hiroshi

臨床神経学 2023.9 (一社)日本神経学会

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炎症性ミクログリアの集団が多系統萎縮症の新規モデルマウスを悪化させる(A population of inflammatory microglia exacerbates a novel mouse model of multiple system atrophy)

Matsuse Dai, Yamaguchi Hiroo, Masaki Katsuhisa, Nishimura Yuji, Tanaka Tatsunori, Saiga Toru, Tanaka Kenji, Yamasaki Ryo, Isobe Noriko, Kira Jun-ichi

臨床神経学 2022.10 (一社)日本神経学会

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生後早期のアレルギーが嗅球の炎症を誘発し自閉症的な特徴を引き起こす(Early postnatal allergy induces inflammation in the olfactory bulb and leads to autistic traits)

Tanaka Eizo, Saitoh Ban-yu, Abdelhadi Amina, Yamasaki Ryo, Isobe Noriko

臨床神経学 2023.9 (一社)日本神経学会

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神経免疫疾患における補体の役割

磯部紀子

補体 2023.8 (一社)日本補体学会

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神経内のC-Cケモカイン受容体2+マクロファージが運動ニューロン疾患モデルマウスを改善する(C-C chemokine receptor 2+ macrophages in nerves ameliorate motor neuron disease model mice)

Yamasaki Ryo, Shiraishi Wataru, Hashimoto Yu, Kou Senri, Isobe Noriko

臨床神経学 2022.10 (一社)日本神経学会

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神経障害性疼痛患者における抗Annexin A2抗体の保有率および抗体陽性患者の臨床的特徴の解明

賀集薫, 藤井敬之, 緒方英紀, 吉富小都, 山崎亮, 磯部紀子

神経免疫学 2023.9 (一社)日本神経免疫学会

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福岡県難病診療連携拠点病院　未診断・未指定難病相談支援センターの現状とこれからの課題

池田由美, 松瀬大, 三田瑶子, 磯部紀子

日本難病医療ネットワーク学会機関誌 2023.11 日本難病医療ネットワーク学会

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筋萎縮性側索硬化症における疾患進行速度の新しい定量的指標(A novel quantitative indicator for disease progression rate in amyotrophic lateral sclerosis)

Kobayakawa Yuko, Todaka Koji, Hashimoto Yu, Ko Senri, Kishimoto Junji, Yamasaki Ryo, Isobe Noriko

臨床神経学 2022.10 (一社)日本神経学会

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筋萎縮性側索硬化症患者の変性運動ニューロンではプレキシンD1の発現が上昇している(Plexin D1 is upregulated in degenerated motor neurons of amyotrophic lateral sclerosis patients)

Fujii Takayuki, Honda Hiroyuki, Yamasaki Ryo, Yoshimura Motoi, Iwaki Toru, Isobe Noriko

臨床神経学 2022.10 (一社)日本神経学会

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脊髄性筋萎縮症(SMA)様の表現型を示したCharcot-Marie-Tooth病(CMT)2CCの一例

稲森有貴子, 緒方英紀, 藤井敬之, 山崎亮, 吉浦孝一郎, 磯部紀子

臨床神経学 2024.1 (一社)日本神経学会

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臨床免疫領域における臓器・組織特異性　多発性硬化症の病因・病態と治療

磯部紀子

日本臨床免疫学会総会プログラム・抄録集 2022.10 (一社)日本臨床免疫学会

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自己免疫性結節症の大規模コホートにおける抗ニューロファシン155抗体のエピトープマッピング(Epitope mapping of anti-neurofascin 155 antibodies in a large cohort of autoimmune nodopathy)

Ogata Hidenori, Abdelhadi Amina, Xu Zhang, Yamasaki Ryo, Kira Jun-ichi, Isobe Noriko

臨床神経学 2023.9 (一社)日本神経学会

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著明な腹部膨隆を呈した顔面肩甲上腕型筋ジストロフィーの一例

宮崎愛理, 入江剛史, 緒方英紀, 渡邉充, 山崎亮, 西野一三, 磯部紀子

臨床神経学 2024.1 (一社)日本神経学会

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難治性神経免疫疾患　抗リウマチ薬イグラチモドは血管内皮細胞に直接作用し免疫細胞の脳内浸潤を抑制する

山崎亮, 永田諭, オズデミル・エズギ , 磯部紀子

日本臨床免疫学会総会プログラム・抄録集 2023.10 (一社)日本臨床免疫学会

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難病診療連携コーディネーターに関する全国アンケート調査

松瀬大, 原田幸子, 深川知栄, 江千里, 磯部紀子

パーキンソン病・運動障害疾患コングレスプログラム・抄録集 2024.7 Movement Disorder Society of Japan (MDSJ)

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フマル酸ジメチル投与は多発性硬化症患者におけるγδT細胞サブセットの特異的変化を来たす(Dimethyl fumarate treatment showed unique change of γδ T cell subsets in multiple sclerosis patients)

Watanabe Mitsuru, Matsuo Eriko, Fukumoto Shoko, Tanaka Eizo, Masaki Katsuhisa, Matsushita Takuya, Kira Jun-ichi, Isobe Noriko

臨床神経学 2022.10 (一社)日本神経学会

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グリアコネキシン低分子量イソフォーム発現エクソソームによる多発性硬化症の増悪機序

中村優理, グザリアイ・ママティジャン , 迫田礼子, 今村友裕, 渡邉充, 磯部紀子, 柳原由記, 岩永育貴, 山下謙一郎, 張旭, 吉良潤一

国際医療福祉大学学会誌 2022.8 国際医療福祉大学学会

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トランスサイレチンは細胞内のアミロイドβを連結することでアルツハイマー病に好影響を与える(Transthyretin has a positive effect on Alzheimer's disease by connecting intracellular Amyloid-beta)

Mizuno Yuri, Honda Hiroyuki, Noguchi Hideko, Koyama Sachiko, Murai Hiroyuki, Isobe Noriko

臨床神経学 2023.9 (一社)日本神経学会

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エクソソームGJA1-29k翻訳アイソフォームは急性視神経脊髄炎の新規血中バイオマーカーである(Exosome GJA1-29k translational isoform is a novel blood biomarker for acute neuromyelitis optica)

Guzailiayi Maimaitijiang, Kira Jun-ichi, Nakamura Yuri, Watanabe Mitsuru, Sakoda Ayako, Masaki Katsuhisa, Nagata Satoshi, Yamaguchi Hiroo, Yamasaki Ryo, Isobe Noriko, Zhang Xu, Imamura Tomohiro

臨床神経学 2022.10 (一社)日本神経学会

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エクソソーム中のコネキシン43(Cx43)低分子量イソフォームとグリア線維性酸性蛋白質(GFAP)は視神経脊髄炎(NMOSD)再発の血液バイオマーカーである

Maimaitijiang Guzailiayi, 中村優理, 今村友裕, 渡邉充, 迫田礼子, 張旭, 磯部紀子, 吉良潤一

国際医療福祉大学学会誌 2022.8 国際医療福祉大学学会

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カルレチニンはミクログリアを活性化しALSの臨床的重症度に関連するCC-motif ligand 2を産生する(Calretinin activates microglia to produce CC-motif ligand 2 relevant to clinical severity of ALS)

Hayashi Shintaro, Yamasaki Ryo, Kobayakawa Yuko, Kira Jun-ichi, Isobe Noriko

臨床神経学 2023.9 (一社)日本神経学会

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クリーゼを繰り返し中咽頭癌合併が判明した全身型重症筋無力症(MG)の一例

藤原麗, 向野隆彦, 藤井敬之, 平野雄介, 山崎亮, 磯部紀子

臨床神経学 2024.3 (一社)日本神経学会

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イグラチモドは進行性多発性硬化症モデルにおいてグリアIL-6産生とTh17遊走を阻害する(Iguratimod blocks glial IL-6 production and Th17 migration in a progressive multiple sclerosis model)

Nagata Satoshi, Yamasaki Ryo, Ozdemir Ezgi, Kashu Kaoru, Matsuo Eriko, Yamaguchi Hiroo, Watanabe Mitsuru, Masaki Katsuhisa, Kira Jun-ichi, Isobe Noriko

臨床神経学 2023.9 (一社)日本神経学会

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エクソソームGJA1-29kはグリア炎症を反映する進行性多発性硬化症の血中マーカーである(Exosome GJA1-29k is a blood marker for progressive multiple sclerosis reflecting glial inflammation)

Guzailiaryi Maimaitijiang, Kira Jun-ichi, Sakoda Ayako, Masaki Katsuhisa, Watanabe Mitsuru, Nagata Satoshi, Ezgi Ozdemir, Yamasaki Ryo, Isobe Noriko, Zhang Xu, Imamura Tomohiro, Nakamura Yuri

臨床神経学 2023.9 (一社)日本神経学会

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イグラチモドは二次性進行性多発性硬化症モデルマウスの臨床症状を改善する(Iguratimod ameliorates clinical signs of the secondary progressive multiple sclerosis model mice)

Nagata Satoshi, Yamasaki Ryo, Ozdemir Ezgi, Kashu Kaoru, Yamaguchi Hiroo, Masaki Katsuhisa, Kira Jun-ichi, Isobe Noriko

臨床神経学 2022.10 (一社)日本神経学会

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アストログリアCx43ヘミチャネルの遮断によるMSモデルマウスのCNS炎症の改善(Blocking of astroglial Cx43 hemichannel successfully ameliorates CNS inflammation in MS model mice)

Ozdemir Ezgi, Yamasaki Ryo, Nagata Satoshi, Watanabe Mitsuru, Yamaguchi Hiroo, Masaki Katsuhisa, Kira Jun-ichi, Takeuchi Hideyuki, Isobe Noriko

臨床神経学 2023.9 (一社)日本神経学会

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SEMA-プレキシン経路を標的とした新規神経障害性疼痛治療法の開発(Development of novel neuropathic pain treatments targeting SEMA-Plexin pathway)

Yoshidomi Sato, Fujii Takayuki, Honda Hiroyuki, Kashu Kaoru, Miyachi Yukino, Ogata Hidenori, Yamasaki Ryo, Iwaki Toru, Isobe Noriko

臨床神経学 2023.9 (一社)日本神経学会

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Semaphorin 3Eを標的とした新規神経障害性疼痛治療薬の開発

吉富小都, 藤井敬之, 本田裕之, 賀集薫, 宮地佑希野, 緒方英紀, 山崎亮, 岩城徹, 磯部紀子

末梢神経 2023.12 日本末梢神経学会

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Semaphorin 3Eを標的とする新規神経障害性疼痛治療薬の開発

吉富小都, 藤井敬之, 本田裕之, 賀集薫, 宮地佑希野, 緒方英紀, 山崎亮, 岩城徹, 磯部紀子

神経免疫学 2023.9 (一社)日本神経免疫学会

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PCBP2はALSにおいて変性神経細胞で発現低下し稀にスケイン様封入体で観察される(PCBP2 is downregulated in degenerating neurons and rarely observed in skein-like inclusions in ALS)

Yoshimura Motoi, Honda Hiroyuki, Sasagasako Naokazu, Mori Shinichiro, Ishii Takashi, Ninomiya Toshiharu, Isobe Noriko, Iwaki Toru

臨床神経学 2022.10 (一社)日本神経学会

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ALS患者の脊髄軸索と脳脊髄液におけるカルレチニンの最初の評価(The first evaluation of calretinin in the spinal axons and cerebrospinal fluids of ALS patients)

Hayashi Shintaro, Yamasaki Ryo, Kobayakawa Yuko, Isobe Noriko, Kira Jun-ichi

臨床神経学 2022.10 (一社)日本神経学会

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Astroglial connexin 43は慢性多発性硬化症モデルの新規治療標的である(Astroglial connexin 43 is a novel therapeutic target for a chronic multiple sclerosis model)

Ozdemir Ezgi, Yamasaki Ryou, Nagata Satoshi, Watanabe Mitsuru, Yamaguchi Hiroo, Masaki Katsuhisa, Kira Jun-ichi, Takeuchi Hideyuki, Isobe Noriko

臨床神経学 2022.10 (一社)日本神経学会

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IgG4抗ニューロファシン155抗体および抗コンタクチン-1抗体の標準化ELISAキットの開発(Development of standardized ELISA kits for IgG4 anti-neurofascin 155 and anti-contactin-1 antibodies)

Ogata Hidenori, Kobayakawa Yuko, Abdelhadi Amina, Yamasaki Ryo, Kawasaki Atsushi, Takeuchi Chieri, Kira Jun-ichi, Isobe Noriko

臨床神経学 2022.10 (一社)日本神経学会

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Iguratimodは二次進行性多発性硬化症モデルマウスの臨床徴候を改善する(Iguratimod ameliorates clinical signs of the secondary progressive multiple sclerosis model mice)

Nagata Satoshi, Yamasaki Ryo, Ozdemir Ezgi, Kashu Kaoru, Yamaguchi Hiroo, Masaki Katsuhisa, Kira Jun-ichi, Isobe Noriko

神経免疫学 2022.10 (一社)日本神経免疫学会

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LGI4-IgG4陽性炎症性脱髄性多発ニューロパチーの臨床的特徴とメカニズム(Clinical features and mechanism of LGI4-IgG4-positive inflammatory demyelinating polyneuropathy)

Zhang Xu, Kira Jun-ichi, Ogata Hidenori, Sakoda Ayako, Kobayashi Masaki, Kitagawa Kazuo, Namihira Yukihiro, Ohya Yusuke, Imamura Tomohiro, Maimaitijiang Guzailiayi, Yamasaki Ryo, Isobe Noriko, Nakamura Yuri

臨床神経学 2022.10 (一社)日本神経学会

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LGI4抗体陽性autoimmune nodopathyにおけるIgG2自己抗体とIVIg反応およびonion-bulb形成との関連(IgG2 autoantibody relates to IVIg response and onion bulb formation in LGI4+ autoimmune nodopathy)

Zhang Xu, Kira Jun-ichi, Yokote Akira, Sakoda Ayako, Mishima Takayasu, Tsuboi Yoshio, Sato Ryota, Kanda Takashi, Ogata Hidenori, Isobe Noriko, Kobayashi Masaki, Kitagawa Kazuo, Namihira Yukihiro, Ohya Yusuke, Fukata Yuko, Fukata Masaki, Imamura Tomohiro, Maimaitijiang Guzailiayi, Nakamura Yuri

臨床神経学 2023.9 (一社)日本神経学会

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MICROGLIA-DERIVED PROTEIN, GALECTIN-3, HAS POSITIVE CORRELATION WITH MOTOR NEURON DEGENERATION, BUT NOT USEFUL FOR DIAGNOSTIC MARKER(タイトル和訳中)

Hayashi Shintaro, Yamasaki Ryo, Kobayakawa Yuko, Kira Jun-ichi, Isobe Noriko

Clinical and Experimental Neuroimmunology 2024.5 (一社)日本神経免疫学会

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MS3　Astroglial connexin 43は慢性多発性硬化症モデルにおける新規治療標的である(MS3　Astroglial connexin 43 is a novel therapeutic target for a chronic multiple sclerosis model)

Ozdemir Ezgi, Yamasaki Ryo, Nagata Satoshi, Watanabe Mitsuru, Yamaguchi Hiroo, Masaki Katsuhisa, Kira Junichi, Takeuchi Hideyuki, Isobe Noriko

神経免疫学 2022.10 (一社)日本神経免疫学会

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MISC

【大変革時代の到来　薬局・薬剤師の新しい価値を創る】薬局の価値を創る3つの視点　新しい時代に則した薬局機能を高める業務開拓　患者ファーストを考えるときに何をする?!

磯部紀子

調剤と情報 30 ( 8 ) 1134 - 1136 2024.6 （ ISSN:1341-5212 ）

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患者から「いつまで待たされるの?」「医師と同じことを聞かないで」と言われたことは薬局に勤務する薬剤師なら一度はあるのではないか。処方内容を鑑査しつつお薬手帳や薬歴を確認し,処方箋の妥当性を判断し,場合に応じて疑義照会し,患者のために適切な内容と量の薬を調剤し,投薬し,重要かつ十分な情報とその後のフォローを提供するにはそれなりに時間が必要である。しかし患者は待ってくれない。患者が満足感を得て治療に前向きな気持ちになってもらうために,私たちは何を考えてどう動けば1秒を削り出すことができ,その時間を患者に向けられるだろうか。(著者抄録)
Opening the doors of opportunity

Noriko Isobe

Nature Immunology 2024.3

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DOI： 10.1038/s41590-024-01771-7
新春企画 In My Resident Life

磯部紀子

週刊医学界新聞 2024.1

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【神経免疫疾患-病態から最新治療まで】多発性硬化症のコホート研究

磯部紀子

脳神経内科 100 ( 1 ) 26 - 28 2024.1 （ ISSN:2434-3285 ）

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小脳性運動失調を主徴とした抗contactin-1(CNTN1)抗体陽性nodopathyの一例

河田由香, 池田和奈, 種本真将, 横川和樹, 山田稔, 齋藤太郎, 岩原直敏, 松村晃寛, 鈴木秀一郎, 緒方英紀, 磯部紀子, 久原真

臨床神経学 2023.11

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重症筋無力症・心筋炎・肝炎を合併したirAE筋炎に対し免疫治療が有効であった1例

芹野南美, 眞崎勝久, 向野隆彦, 入江剛史, 山崎亮, 磯部紀子

臨床神経学 2023.10

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アルツハイマー型認知症の脳内におけるトランスサイレチンの発現様式の検討

水野裕理, 本田裕之, 二宮利治, 磯部紀子, 村井弘之

2023.10

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エクリズマブからラブリズマブへの切り替え後増悪傾向となった全身型重症筋無力症の一例

坂上晴紀, 吉村廣紀, 渡邉充, 入江剛史, 田中栄蔵, 山崎亮, 磯部紀子

臨床神経学 2023.10

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妊娠悪阻を契機に診断に至った極長鎖アシルCoA脱水素酵素欠損症の1例

白石渉, 立石貴久, 林田翔太郎, 但馬剛, 津村弥来, 磯部紀子

臨床神経学 2023.10

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症例は25歳女性,12歳から横紋筋融解症を繰り返していた.妊娠悪阻による飢餓を契機に横紋筋融解症が再燃し,当科紹介となった.血液検査でCK値の上昇と,総カルニチンの低下を認めた.末梢血リンパ球のpalmitoyl-CoA dehydrogenase活性が低値であり,極長鎖アシルCoA脱水素酵素(very-long-chain acyl-coenzyme A dehydrogenase,以下VLCADと略記)欠損症と診断した.ACADVL遺伝子のc.1349G>A(p.R450H)変異に加え,c.1332G>A変異との複合ヘテロ変異を認めた.VLCAD欠損症は脂肪酸酸化異常症の一つで,横紋筋融解症を生じうる.未診断のVLCAD欠損症が妊娠悪阻を契機に診断に至ることがある.(著者抄録)
神経筋疾患の問題症例亜急性に進行した小脳性運動失調症と脱髄性ニューロパチーの一例

河田由香, 池田和奈, 山田稔, 齋藤太郎, 津田玲子, 鈴木秀一郎, 緒方英紀, 磯部紀子, 久原真

臨床神経生理学 2023.10

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視床下部アルツハイマー病理はBMI低値と相関する久山町研究

八木田薫, 本田裕之, 小原知之, 山崎亮, 磯部紀子, 二宮利治

2023.10

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重症筋無力症・心筋炎・肝炎を合併したirAE筋炎に対し免疫治療が有効であった1例

芹野南美, 眞崎勝久, 向野隆彦, 入江剛史, 山崎亮, 磯部紀子

臨床神経学 2023.10

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神経筋疾患の問題症例亜急性に進行した小脳性運動失調症と脱髄性ニューロパチーの一例

河田由香, 池田和奈, 山田稔, 齋藤太郎, 津田玲子, 鈴木秀一郎, 緒方英紀, 磯部紀子, 久原真

臨床神経生理学 2023.10

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視床下部アルツハイマー病理はBMI低値と相関する久山町研究

八木田薫, 本田裕之, 小原知之, 山崎亮, 磯部紀子, 二宮利治

2023.10

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頭蓋内脳波記録に対し深層学習を用いて行ったてんかん原性領域の自動推定

岡留敏樹, 山口高弘, 向野隆彦, 渡邉恵利子, 酒田あゆみ, 下川能史, 迎伸孝, 森岡隆人, 磯部紀子, 重藤寛史

臨床神経学 2023.9

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ALSモデルマウスの脊髄におけるマクロファージ/ミクログリア動態の検討

江千里, 橋本侑, 小早川優子, 山崎亮, 磯部紀子

神経免疫学 2023.9

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Balo型同心円硬化症様の同心円状病変を呈した8例の臨床的特徴

岩尾和紀, 眞崎勝久, 吉良雄一, 田中栄蔵, 渡邉充, 磯部紀子

神経免疫学 2023.9

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CAR-T細胞療法に伴い非痙攣性てんかん重積状態を呈した2例

向野隆彦, 山口高弘, 松村尚, 松尾知恵, 中尾文彦, 陣之内文昭, 山内拓司, 加藤光次, 松本航, 渡邉恵利子, 酒田あゆみ, 赤司浩一, 磯部紀子, 重藤寛史

てんかん研究 2023.9

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コネキシン30欠損はグリア炎症を抑制することでALSモデルマウスの発症早期の疾患進行を緩和する

橋本侑, 山崎亮, 江千里, 小早川優子, 眞崎勝久, 松瀬大, 松下拓也, 磯部紀子

神経免疫学 2023.9

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フィンゴリモドおよびフマル酸ジメチル使用多発性硬化症患者の疾患活動性関連細胞分画

渡邉充, 松尾江梨子, 福元尚子, 田中栄蔵, 小柳文乃, 眞崎勝久, 松下拓也, 吉良潤一, 磯部紀子

臨床神経学 2023.9

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中枢神経作用コネキシン阻害薬による多系統萎縮症小脳型モデルマウスの治療

原田雅也, 眞崎勝久, 松瀬大, 山口浩雄, 西村由宇慈, 高瀬オズデミールエズギ, 田中栄蔵, 田中辰典, 山崎亮, 竹内英之, 谷脇考恭, 磯部紀子, 吉良潤一

神経免疫学 2023.9

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多発性硬化症における頭部全脊髄MRIでの多発T2病変とフマル酸ジメチルによる再発抑制効果との関連性の検討

田中栄蔵, 渡邉充, 篠田紘司, 眞崎勝久, 松下拓也, 磯部紀子

神経免疫学 2023.9

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活性化ミクログリアが産生する蛋白に着目した運動神経細胞変性相関因子の同定と診断バイオマーカーの探求

林信太郎, 山崎亮, 小早川優子, 吉良潤一, 磯部紀子

神経免疫学 2023.9

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狭心症およびパニック発作と鑑別を要した自己免疫性脳炎の一例

増本政也, 本岡大道, 安元眞吾, 稲森有貴子, 向野隆彦, 渡邉充, 磯部紀子, 小曽根基裕, 中川伸

てんかん研究 2023.9

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発作間欠期てんかん性放電による背景脳波の変化を機械学習にて検出する試み

山口高弘, 岡留敏樹, 向野隆彦, 上原平, 下川能史, 重藤寛史, 磯部紀子

臨床神経学 2023.9

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罹病後長期間経過してもステロイドが有効であった抗NF155抗体陽性自己免疫性ノドパチーの一例

吉濱れい, 小林正樹, 緒方英紀, 磯部紀子, 日熊麻耶, 齋藤和幸, 和田義明

神経免疫学 2023.9

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脱髄性ニューロパチー患者における大径線維障害と小径線維障害の関連についての検討

藤井敬之, 緒方英紀, 田代匠, 井ノ上有香, 山崎亮, 磯部紀子

神経免疫学 2023.9

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頭蓋内脳波記録に対し深層学習を用いて行ったてんかん原性領域の自動推定

岡留敏樹, 山口高弘, 向野隆彦, 渡邉恵利子, 酒田あゆみ, 下川能史, 迎伸孝, 森岡隆人, 磯部紀子, 重藤寛史

臨床神経学 2023.9

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狭心症およびパニック発作と鑑別を要した自己免疫性脳炎の一例

増本政也, 本岡大道, 安元眞吾, 稲森有貴子, 向野隆彦, 渡邉充, 磯部紀子, 小曽根基裕, 中川伸

てんかん研究 2023.9

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発作間欠期てんかん性放電による背景脳波の変化を機械学習にて検出する試み

山口高弘, 岡留敏樹, 向野隆彦, 上原平, 下川能史, 重藤寛史, 磯部紀子

臨床神経学 2023.9

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罹病後長期間経過してもステロイドが有効であった抗NF155抗体陽性自己免疫性ノドパチーの一例

吉濱れい, 小林正樹, 緒方英紀, 磯部紀子, 日熊麻耶, 齋藤和幸, 和田義明

神経免疫学 2023.9

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脱髄性ニューロパチー患者における大径線維障害と小径線維障害の関連についての検討

藤井敬之, 緒方英紀, 田代匠, 井ノ上有香, 山崎亮, 磯部紀子

神経免疫学 2023.9

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【Antibody Update 2023 Part1 中枢編】視神経脊髄炎関連疾患

飯田紘太郎, 磯部紀子

BRAIN and NERVE: 神経研究の進歩 2023.6

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＜文献概要＞視神経脊髄炎関連疾患は主に視神経炎,脊髄炎をきたす中枢性自己免疫性疾患であり,その病態生理にアクアポリン4(aquaporin-4:AQP4)抗体が関わっている。AQP4抗体は補体や細胞性免疫の活性化によりアストロサイトの傷害や二次的な脱髄,神経障害をきたす。従来はステロイド中心の治療であったが,特に再発予防治療において有効性の高い生物学的製剤が登場した。ステロイド治療による副作用の軽減や患者QOLの向上が期待される。
小脳性運動失調で発症し,中枢性尿崩症と骨病変から診断し得たErdheim-Chester病の1例

芹野南美, 眞崎勝久, 向野隆彦, 松吉彩乃, 山崎亮, 磯部紀子

臨床神経学 2023.5

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膠原病リウマチ医に知って頂きたい神経診察と神経疾患

磯部紀子

日本リウマチ学会総会・学術集会プログラム・抄録集 2023.3

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膠原病リウマチ医に知って頂きたい神経診察と神経疾患

磯部紀子

日本リウマチ学会総会・学術集会プログラム・抄録集 2023.3

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踵膝試験での右下肢の「さまよう動き」を契機に診断に至った大脳皮質基底核症候群(CBS)の1例

内和田英人, 藤井敬之, 緒方英紀, 山崎亮, 磯部紀子

臨床神経学 2023.2

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Hereditary myopathy with early respiratory failure(HMERF)の1例

宮崎哲, 緒方英紀, 吉村基, 向野隆彦, 渡邉充, 山崎亮, 本田裕之, 西野一三, 磯部紀子

臨床神経学 2023.2

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踵膝試験での右下肢の「さまよう動き」を契機に診断に至った大脳皮質基底核症候群(CBS)の1例

内和田英人, 藤井敬之, 緒方英紀, 山崎亮, 磯部紀子

臨床神経学 2023.2

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多発性硬化症（MS）の最新治療戦略.

磯部紀子

神経治療学 40 ( 3 ) 2023

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治療法の再整理とアップデートのために専門家による私の治療　多発性硬化症(MS)・視神経脊髄炎(NMOSD)

磯部紀子

日本医事新報 ( 5147 ) 44 - 44 2022.12 （ ISSN:0385-9215 ）

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上腕二頭筋生検で診断に至らず,外眼筋組織で遺伝子診断に至った慢性進行性外眼筋麻痺の1例

白石渉, 立石貴久, 橋本侑, 山崎亮, 吉良潤一, 磯部紀子

臨床神経学 2022.12

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症例は初診時48歳の男性.緩徐進行性の複視を主訴に当科を受診した.家族歴はなく,エドロホニウムテストは陰性だった.血液検査で乳酸とピルビン酸値の上昇を認め,ミトコンドリア病を疑い,上腕二頭筋を生検したが筋病理,遺伝子検査とも異常は認められなかった.患者は後日,複視に対し眼筋縫縮術を施行された.その際に得られた組織で,ミトコンドリア遺伝子の多重欠失を認め,慢性進行性外眼筋麻痺の診断に至った.本例は上腕二頭筋組織に異常を認めず,外眼筋組織で遺伝子異常を認め,診断に至った.ミトコンドリア病では,ミトコンドリア遺伝子異常の組織特異性が指摘されており,生検を施行する際には罹患筋を選択することが望ましい.(著者抄録)
Non-IgG4抗体neurofascin155抗体陽性症例における臨床像の検討

緒方英紀, Abdelhadi Amina, 山崎亮, 吉良潤一, 磯部紀子

末梢神経 2022.12

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上腕二頭筋生検で診断に至らず,外眼筋組織で遺伝子診断に至った慢性進行性外眼筋麻痺の1例

白石渉, 立石貴久, 橋本侑, 山崎亮, 吉良潤一, 磯部紀子

臨床神経学 2022.12

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症例は初診時48歳の男性.緩徐進行性の複視を主訴に当科を受診した.家族歴はなく,エドロホニウムテストは陰性だった.血液検査で乳酸とピルビン酸値の上昇を認め,ミトコンドリア病を疑い,上腕二頭筋を生検したが筋病理,遺伝子検査とも異常は認められなかった.患者は後日,複視に対し眼筋縫縮術を施行された.その際に得られた組織で,ミトコンドリア遺伝子の多重欠失を認め,慢性進行性外眼筋麻痺の診断に至った.本例は上腕二頭筋組織に異常を認めず,外眼筋組織で遺伝子異常を認め,診断に至った.ミトコンドリア病では,ミトコンドリア遺伝子異常の組織特異性が指摘されており,生検を施行する際には罹患筋を選択することが望ましい.(著者抄録)
Non-IgG4抗体neurofascin155抗体陽性症例における臨床像の検討

緒方英紀, Abdelhadi Amina, 山崎亮, 吉良潤一, 磯部紀子

末梢神経 2022.12

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神経系と免疫の接点(第4回)　多発性硬化症と免疫系

田中栄蔵, 磯部紀子, 村上正晃

炎症と免疫 30 ( 6 ) 524 - 527 2022.10 （ ISSN:0918-8371 ）

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多発性硬化症(MS)は中枢神経系における炎症性脱髄疾患である.近年,その病態において旧来いわれてきたT細胞主体の炎症という概念から,B細胞による抗原提示やサイトカイン産生,また慢性炎症におけるミクログリアの役割などが明らかとなり,多くの免疫関連細胞が複雑に相互作用していることが明らかになってきた.本稿ではMSの免疫学的異常に加えて,中枢神経と免疫系との境界となる,血液脳関門のMS病態における破綻にも注目して概説する.(著者抄録)
視神経脊髄炎(NMOSD)再発時の神経障害と関連する新規血液エクソソーム(Ex)マーカー

グザリアイ・ママティジャン, 中村優理, 渡邉充, 迫田礼子, 今村友裕, 張旭, 磯部紀子, 吉良潤一

神経免疫学 2022.10

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MS1 日本人多発性硬化症患者におけるグラチラマー酢酸塩の有効性に関与する因子の検討

田中栄蔵, 渡邉充, 福元尚子, 眞崎勝久, 松下拓也, 磯部紀子

神経免疫学 2022.10

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MS2 第5回全国調査からみる多発性硬化症の二次性進行型に移行するリスク因子の検討

渡邉充, 磯部紀子, 新野正明, 中島一郎, 松下拓也, 酒井康成, 中原仁, 河内泉, 越智博文, 中辻裕司, 中村好一, 中村幸志, 坂田清美, 松井真, 桑原聡, 吉良潤一

神経免疫学 2022.10

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Pros & Cons 2022年の多発性硬化症診療を考える参加者と共に考える「多発性硬化症におけるB細胞除去療法」

磯部紀子

神経免疫学 2022.10

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その他カルシウム結合蛋白に着目したミクログリアからの筋萎縮性側索硬化症重症度関連ケモカイン放出因子の解明

林信太郎, 山崎亮, 吉良潤一, 磯部紀子

神経免疫学 2022.10

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その他多系統萎縮症におけるconnexin蛋白群の早期かつ広範な変化と脱髄病態との関連

西村由宇慈, 眞崎勝久, 松瀬大, 山口浩雄, 田中辰典, 貞島祥子, 笹ヶ迫直一, 山崎亮, 磯部紀子, 岩城徹, 吉良潤一

神経免疫学 2022.10

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中枢神経脱髄におけるオリゴデンドログリア変性によるミクログリア活性化メカニズムの解明

松下拓也, 西村由宇慈, 眞崎勝久, 松瀬大, 山口浩雄, 吉良潤一, 磯部紀子

神経免疫学 2022.10

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定量的IgG4抗neurofascin 155抗体、抗contactin-1抗体測定ELISAキットの有用性

緒方英紀, 小早川優子, 川嵜淳史, 竹内智枝理, 山崎亮, 吉良潤一, 磯部紀子

神経免疫学 2022.10

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当科で経験したBalo病6例の臨床的特徴および画像所見に関する検討

眞崎勝久, 松下拓也, 渡邉充, 福元尚子, 田中栄蔵, 磯部紀子

臨床神経学 2022.10

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抗NF155抗体陽性ニューロパチーの小脳機能に関する生理学的検討

種田建太, 清水崇宏, 守安正太郎, 松本正太, 緒方英紀, 磯部紀子, 宇川義一, 花島律子

臨床神経生理学 2022.10

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日本人の遺伝学的背景と多発性硬化症・視神経脊髄炎との関連

松下拓也, 渡邉充, 山本健, 福元尚子, 田中栄蔵, 吉良潤一, 磯部紀子

臨床神経学 2022.10

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日本人多発性硬化症患者における高次脳機能とMRIパラメータ変化との関連

福元尚子, 渡邉充, 新野正明, 松下拓也, 眞崎勝久, 迫田礼子, 林史恵, 吉良潤一, 磯部紀子

神経免疫学 2022.10

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末梢神経疾患1 定量的感覚検査を用いた自己免疫性ノドパチーにおける小径線維障害の検討

藤井敬之, 緒方英紀, 山崎亮, 磯部紀子

神経免疫学 2022.10

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脊髄炎とその鑑別疾患

磯部紀子

臨床神経学 2022.10

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視神経脊髄炎(NMOSD)再発時の神経障害と関連する新規血液エクソソーム(Ex)マーカー

グザリアイ・ママティジャン, 中村優理, 渡邉充, 迫田礼子, 今村友裕, 張旭, 磯部紀子, 吉良潤一

神経免疫学 2022.10

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MS1 日本人多発性硬化症患者におけるグラチラマー酢酸塩の有効性に関与する因子の検討

田中栄蔵, 渡邉充, 福元尚子, 眞崎勝久, 松下拓也, 磯部紀子

神経免疫学 2022.10

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MS2 第5回全国調査からみる多発性硬化症の二次性進行型に移行するリスク因子の検討

渡邉充, 磯部紀子, 新野正明, 中島一郎, 松下拓也, 酒井康成, 中原仁, 河内泉, 越智博文, 中辻裕司, 中村好一, 中村幸志, 坂田清美, 松井真, 桑原聡, 吉良潤一

神経免疫学 2022.10

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Pros & Cons 2022年の多発性硬化症診療を考える参加者と共に考える「多発性硬化症におけるB細胞除去療法」

磯部紀子

神経免疫学 2022.10

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その他カルシウム結合蛋白に着目したミクログリアからの筋萎縮性側索硬化症重症度関連ケモカイン放出因子の解明

林信太郎, 山崎亮, 吉良潤一, 磯部紀子

神経免疫学 2022.10

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その他多系統萎縮症におけるconnexin蛋白群の早期かつ広範な変化と脱髄病態との関連

西村由宇慈, 眞崎勝久, 松瀬大, 山口浩雄, 田中辰典, 貞島祥子, 笹ヶ迫直一, 山崎亮, 磯部紀子, 岩城徹, 吉良潤一

神経免疫学 2022.10

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中枢神経脱髄におけるオリゴデンドログリア変性によるミクログリア活性化メカニズムの解明

松下拓也, 西村由宇慈, 眞崎勝久, 松瀬大, 山口浩雄, 吉良潤一, 磯部紀子

神経免疫学 2022.10

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定量的IgG4抗neurofascin 155抗体、抗contactin-1抗体測定ELISAキットの有用性

緒方英紀, 小早川優子, 川嵜淳史, 竹内智枝理, 山崎亮, 吉良潤一, 磯部紀子

神経免疫学 2022.10

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当科で経験したBalo病6例の臨床的特徴および画像所見に関する検討

眞崎勝久, 松下拓也, 渡邉充, 福元尚子, 田中栄蔵, 磯部紀子

臨床神経学 2022.10

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抗NF155抗体陽性ニューロパチーの小脳機能に関する生理学的検討

種田建太, 清水崇宏, 守安正太郎, 松本正太, 緒方英紀, 磯部紀子, 宇川義一, 花島律子

臨床神経生理学 2022.10

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日本人の遺伝学的背景と多発性硬化症・視神経脊髄炎との関連

松下拓也, 渡邉充, 山本健, 福元尚子, 田中栄蔵, 吉良潤一, 磯部紀子

臨床神経学 2022.10

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日本人多発性硬化症患者における高次脳機能とMRIパラメータ変化との関連

福元尚子, 渡邉充, 新野正明, 松下拓也, 眞崎勝久, 迫田礼子, 林史恵, 吉良潤一, 磯部紀子

神経免疫学 2022.10

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末梢神経疾患1 定量的感覚検査を用いた自己免疫性ノドパチーにおける小径線維障害の検討

藤井敬之, 緒方英紀, 山崎亮, 磯部紀子

神経免疫学 2022.10

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脊髄炎とその鑑別疾患

磯部紀子

臨床神経学 2022.10

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【神経疾患における遺伝医療の進歩】多発性硬化症

磯部紀子

日本内科学会雑誌 111 ( 8 ) 1555 - 1559 2022.8 （ ISSN:0021-5384 ）

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【多発性硬化症・視神経脊髄炎スペクトラム障害(NMOSD)の病態と診断】抗MOG抗体陽性視神経脊髄炎の病態と診断

福元尚子, 磯部紀子

脳神経内科 97 ( 2 ) 165 - 168 2022.8 （ ISSN:2434-3285 ）

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【免疫性神経疾患(第2版)-基礎・臨床の最新知見-】知っておきたい免疫性神経疾患の遺伝的要因

林史恵, 磯部紀子

日本臨床 80 ( 増刊5 免疫性神経疾患 ) 18 - 23 2022.5 （ ISSN:0047-1852 ）

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神経免疫疾患の診断・重症度分類・ガイドラインの妥当性検証・改定と全国調査による患者QOLの改善の検証第5回全国調査からみた多発性硬化症の重症度に寄与する因子の検討

磯部紀子, 渡邉充, 新野正明, 中島一郎, 松下拓也, 酒井康成, 中原仁, 河内泉, 河内泉, 越智博文, 中辻裕司, 福元尚子, 林史恵, 宮崎雄生, 藤盛寿一, 久冨木原健二, 奥野龍禎, 中村優理, 中村優理, 迫田礼子, 米元耕輔, 平良遼志, 野村恭一, 山村隆, 藤原一男, 田中正美, 錫村明生, 清水優子, 清水潤, 園生雅弘, 松尾秀徳, 渡邊修, 深澤俊行, 荻野美恵子, 郡山達男, 斎田孝彦, 野村芳子, 横山和正, 神田隆, 田原将行, 横田隆徳, 大橋高志, 鈴木則宏, 楠進, 栗山長門, 栗山長門, 和泉唯信, 小池春樹, 佐藤泰憲, 三澤園子, 村井弘之, 本村政勝, 吉川弘明, 中西恵美, 中村好一, 中村幸志, 坂田清美, 嶋田莉奈子, 松井真, 桑原聡, 吉良潤一, 吉良潤一, 吉良潤一

神経免疫疾患のエビデンスに基づく診断基準・重症度分類・ガイドラインの妥当性と患者QOLの検証令和3年度総括・分担研究報告書(Web) 2022

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多発性硬化症におけるエピジェネティクス機構

磯部紀子

2021.1

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【免疫性神経疾患update-基礎・臨床研究の最新知見-】多発性硬化症・視神経脊髄炎の疫学

磯部紀子, 吉良潤一

日本臨床 2020.11

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第5回全国疫学調査が示す多発性硬化症・視神経脊髄炎総患者数の顕著な増加傾向の持続

磯部紀子, 新野正明, 松下拓也, 中村優理, 中島一郎, 渡邉充, 酒井康成, 迫田礼子, 中原仁, 河内泉, 越智博文, 中辻裕司, 福元尚子, 林史恵, 中村好一, 中村幸志, 坂田清美, 嶋田莉奈子, 松井真

臨床神経学 2020.11

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フィンゴリモドを長期使用した日本人多発性硬化症患者で残存する疾患活動性に関するリンパ球分画の同定

渡邉充, 松尾江梨子, グザリアイ・ママティジャン, 迫田礼子, 福元尚子, 林史恵, 眞崎勝久, 磯部紀子, 松下拓也, 吉良潤一

神経免疫学 2020.10

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日本人多発性硬化症患者における高次脳機能(BICAMS)とMRIパラメータとの関連

福元尚子, 渡邉充, 新野正明, 磯部紀子, 松下拓也, 眞崎勝久, 迫田礼子, 林史恵, 吉良潤一

神経免疫学 2020.10

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フマル酸ジメチル導入による多発性硬化症再発抑制効果とその関連因子

松下拓也, 磯部紀子, 眞崎勝久, 渡邉充, 福元尚子, 林史恵, 中村優理, 迫田礼子, 吉良潤一

神経免疫学 2020.10

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フィンゴリモドを長期使用した日本人多発性硬化症患者で残存する疾患活動性に関するリンパ球分画の同定

渡邉充, 松尾江梨子, グザリアイ・ママティジャン, 迫田礼子, 福元尚子, 林史恵, 眞崎勝久, 磯部紀子, 松下拓也, 吉良潤一

神経免疫学 2020.10

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第5回全国調査が示す多発性硬化症・視神経脊髄炎総患者数の増加

磯部紀子, 新野正明, 松下拓也, 中村優理, 中島一郎, 渡邉充, 酒井康成, 迫田礼子, 中原仁, 河内泉, 越智博文, 中辻裕司, 福元尚子, 林史恵, 中村好一, 中村幸志, 坂田清美, 嶋田莉奈子, 松井真, 吉良潤一

神経免疫学 2020.10

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日本人多発性硬化症患者における高次脳機能(BICAMS)とMRIパラメータとの関連

福元尚子, 渡邉充, 新野正明, 磯部紀子, 松下拓也, 眞崎勝久, 迫田礼子, 林史恵, 吉良潤一

神経免疫学 2020.10

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免疫介在性疾患の病因追究手段としてのHLAその他の遺伝子解析手法の原理と臨床的意義づけ

磯部紀子

神経免疫学 2020.10

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フマル酸ジメチル導入による多発性硬化症再発抑制効果とその関連因子

松下拓也, 磯部紀子, 眞崎勝久, 渡邉充, 福元尚子, 林史恵, 中村優理, 迫田礼子, 吉良潤一

神経免疫学 2020.10

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HLA-DRB1*15:01保有多発性硬化症患者は白質容積の萎縮が速く、DRB1*04:05保有者は病巣容積の増加が遅い

福元尚子, 中村優理, 渡邉充, 迫田礼子, 磯部紀子, 松下拓也, 吉良潤一

神経治療学 2019.10

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米食の予防効果は多発性硬化症ではみられるが視神経脊髄炎関連疾患ではみられない

迫田礼子, 松下拓也, 中村優理, 渡邉充, 篠田紘司, 磯部紀子, 吉良潤一

神経治療学 2019.10

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MS/NMO 2 日本人における視神経脊髄炎の環境要因についての検討

迫田礼子, 松下拓也, 中村優理, 渡邉充, 篠田絋司, 磯部紀子, 吉良潤一

神経免疫学 2019.9

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日本人視神経脊髄炎とその臨床像に対する全ゲノム関連解析

松下拓也, 佐藤眞也, 山本健, 渡邉充, 中村優理, 磯部紀子, 吉良潤一

神経免疫学 2019.9

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日本人多発性硬化症患者におけるHLAアリルの脳容積に対する影響

福元尚子, 中村優理, 渡邉充, 迫田礼子, 磯部紀子, 松下拓也, 吉良潤一

神経免疫学 2019.9

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抗neurofascin 155抗体関連ニューロパチー全国調査結果

緒方英紀, 山崎亮, 磯部紀子, 角谷真人, 海田賢一, 松井真, 桑原聡, 楠進, 吉良潤一

神経免疫学 2019.9

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MS/NMO1 表現型不一致の一卵性品胎における多発性硬化症関連T細胞受容体レパトア解析

磯部紀子, 林史恵, 渡邉充, 松下拓也, 岡本幸市, 吉良潤一

神経免疫学 2019.9

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MS/NMO1 HLA-DRB1*04:05陽性MS患者におけるサイトメガロウイルス(CMV)関連T細胞受容体の同定

林史恵, 磯部紀子, Glanville Jacob, 渡邉充, 松下拓也, 吉良潤一

神経免疫学 2019.9

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MS/NMO 2 日本人多発性硬化症における疾患修飾薬関連進行性多巣性白質脳症発症リスクにHLAアリル多型が関与する

渡邉充, 中村優理, 磯部紀子, 田中正美, 松下拓也, 河野祐治, 迫田礼子, 林史恵, 吉良潤一

神経免疫学 2019.9

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Link between HLA alleles and anti-NMDAR encephalitis Reviewed

Noriko Isobe

Journal of Neurology, Neurosurgery and Psychiatry 2019.6

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DOI： 10.1136/jnnp-2018-319925
Cerebrospinal fluid cytokine/chemokine/growth factor profiles in idiopathic hypertrophic pachymeningitis. Reviewed

Xu Zhang, Takayuki Fujii, Hidenori Ogata, Ryo Yamasaki, Katsuhisa Masaki, Yiwen Cui, Takuya Matsushita, Noriko Isobe, Jun-Ichi Kira

Journal of neuroimmunology 2019.5

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DOI： 10.1016/j.jneuroim.2019.01.010
Helicobacter pylori infection and demyelinating disease of the central nervous system Reviewed

Jun ichi Kira, Noriko Isobe

Journal of Neuroimmunology 2019.4

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DOI： 10.1016/j.jneuroim.2018.06.017
日本人多発性硬化症における疾患修飾薬関連進行性多巣性白質脳症のリスクにHLAクラスIIアリル多型が関与

渡邉充, 中村優理, 磯部紀子, 松下拓也, 迫田礼子, 林史恵, 吉良潤一

日本内科学会雑誌 2019.2

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多発性硬化症患者におけるT細胞受容体レパトアの解析

林史恵, 磯部紀子, Maimaitijiang Guzailiayi, 中村優理, 篠田紘司, 松下拓也, 吉良潤一

臨床神経学 2018.12

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Facial onset sensory and motor neuronopathy症候群は早期からoral phase dysphagiaを呈する

渡邉充, 白石渉, 山崎亮, 磯部紀子, 吉良潤一

神経治療学 2018.11

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多地点接続症例検討遠隔会議におけるユーザー体感品質を考慮した技術的課題

富松俊太, 工藤孔梨子, 森山智彦, 平井康之, 磯部紀子, 清水周次

日本遠隔医療学会学術大会プログラム・抄録集 2018.11

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【中枢神経系脱髄疾患の最前線-抗MOG抗体の関与を考える】多発性硬化症に自己抗体の関与はあるか遺伝学

磯部紀子

2018.11

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Facial onset sensory and motor neuronopathy症候群は早期からoral phase dysphagiaを呈する

渡邉充, 白石渉, 山崎亮, 磯部紀子, 吉良潤一

神経治療学 2018.11

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A Comparison of Brain MRI Features between Asian and Caucasian Patients with Multiple Sclerosis

Yuri Nakamura, Laura Gaetano, Takuya Matsushita, Altermatt Anna, Till Sprenger, Ernst Wilhelm Radue, Lens Wuerfel, Lorena Bauer, Michael Amann, Koji Shinoda, Noriko Isobe, Ryo Yamasaki, Takahiko Saida, Ludwig Kappos, Jun-ichi Kira

ANNALS OF NEUROLOGY 2018.10

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問題症例の神経筋診断左肩に限局する不随意運動を呈した一例

稲水佐江子, 藤下幸穂, 山下謙一郎, 磯部紀子, 山崎亮, 吉良潤一

臨床神経生理学 2018.10

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日本人多発性硬化症ではHLA-DRB1*15:01がJCV感染リスクを下げDR4がリスクを上げる

渡邉充, 中村優理, 磯部紀子, 松下拓也, 迫田礼子, 林史恵, 吉良潤一

2018.10

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多地点接続症例検討遠隔会議におけるユーザー体感品質を考慮した技術的課題

富松俊太, 工藤孔梨子, 森山智彦, 平井康之, 磯部紀子, 清水周次

日本遠隔医療学会雑誌 2018.10

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A comparison of brain magnetic resonance imaging lesions in multiple sclerosis by race with reference to disability progression. Reviewed

Yuri Nakamura, Laura Gaetano, Takuya Matsushita, Altermatt Anna, Till Sprenger, Ernst-Wilhelm Radue, Jens Wuerfel, Lorena Bauer, Michael Amann, Koji Shinoda, Noriko Isobe, Ryo Yamasaki, Takahiko Saida, Ludwig Kappos, Jun-Ichi Kira

Journal of neuroinflammation 2018.9

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DOI： 10.1186/s12974-018-1295-1
日本人初の多発性硬化症の包括的環境因子調査欧米白人と共通する因子とユニークな因子

迫田礼子, 松下拓也, 中村優理, 渡邉充, 篠田紘司, 磯部紀子, 吉良潤一

神経免疫学 2018.9

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多発性硬化症関連遺伝子が集積する細胞組織特異的発現調整ネットワーク解析日本人ではNK細胞が寄与する

松下拓也, 山本健, 中村優理, 渡邉充, 篠田紘司, 磯部紀子, 吉良潤一, 日本多発性硬化症遺伝コンソーシアム

神経免疫学 2018.9

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MS/NMO 血清GFAPとニューロフィラメント軽鎖は視神経脊髄炎関連疾患や多発性硬化症の障害度や再発率と相関する

渡邉充, 中村優理, Michalak Zuzanna, 林史恵, Barro Christian, 磯部紀子, 松下拓也, 山崎亮, Kuhle Jens, 吉良潤一

神経免疫学 2018.9

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MS/NMO 片親起源効果を用いた新規多発性硬化症リスク遺伝子の探索

磯部紀子, Tsai Andy, Caillier Stacy J., Santaniello Adam, 松下拓也, 吉良潤一, Hauser Stephen L., Oksenberg Jorge R.

神経免疫学 2018.9

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MS/NMO 多発性硬化症におけるT細胞受容体β鎖CDR3中心部のユニークなアミノ酸配列の存在

林史恵, 磯部紀子, 中村優理, 松下拓也, 吉良潤一

神経免疫学 2018.9

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Emerging importance of big data in neuroimmunological research Reviewed

Noriko Isobe

Clinical and Experimental Neuroimmunology 2018.2

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DOI： 10.1111/cen3.12451
Genetics in multiple sclerosis Updates in the era of big data Reviewed

Noriko Isobe

Clinical and Experimental Neuroimmunology 2018.2

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DOI： 10.1111/cen3.12443
MS・NMO2 多発性硬化症患者におけるT細胞受容体レパトアの解析

林史恵, 磯部紀子, Guzailiayi Maimaitijiang, 中村優理, 篠田絋司, 松下拓也, 吉良潤一

神経免疫学 2017.10

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パスウェイバーデン解析による多発性硬化症リスク遺伝子の疾患多様性への寄与の検討

磯部紀子

神経免疫学 2017.10

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American Academy of Neurology 2017 Annual Meeting Reviewed

Noriko Isobe

Clinical and Experimental Neuroimmunology 2017.8

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DOI： 10.1111/cen3.12402
【NMOとMSの最新情報】MS(multiple sclerosis)とCIS(clinically isolated syndrome)の最新の診断基準

磯部紀子, 吉良潤一

脊椎脊髄ジャーナル 2017.8

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Latitude and HLA-DRB1 Alleles Affect Emergence of CSF IgG Abnormalities in MS

Masaaki Niino, Shinya Sato, Toshiyuki Fukazawa, Satoshi Yoshimura, Shin Hisahara, Takuya Matsushita, Yuri Nakamura, Noriko Isobe, Kazuto Yoshida, Hideki Houzen, Yusei Miyazaki, Shun Shimohama, Eri Takahashi, Seiji Kikuchi, Jun-ichi Kira

MULTIPLE SCLEROSIS JOURNAL 2016.3

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多発性硬化症の進行はChGn-1多型と関連する(Progression of multiple sclerosis is associated with ChGn-1 polymorphism)

西郷和真, 吉村怜, 泉川友美, 松下拓也, 磯部紀子, 小池敏靖, 宮本勝一, 平野牧人, 田原康玄, 三木哲郎, 北川裕之, 吉良潤一, 楠進

臨床神経学 2015.12

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Multiple Sclerosis Susceptibility/Resistance and Clinical Manifestations are Determined by HLA-DRB1 Alleles and Latitude in Japanese Patients.

Y. Nakamura, T. Matsushita, S. Sato, M. Niino, T. Fukazawa, S. Yoshimura, S. Hisahara, N. Isobe, S. Shimohama, K. Yoshida, H. Houzen, Y. Miyazaki, S. Kikuchi, J. Kira

MULTIPLE SCLEROSIS JOURNAL 2015.5

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A Combined Neuroimaging and Neuropathological Study for Spinal Cord Lesions of Neuromyelitis Optica: with Special Reference to Lesion Distribution and Extension Patterns

S. Hayashida, K. Masaki, T. Yonekawa, N. Isobe, M. Watanabe, T. Matsushita, J. Kira

MULTIPLE SCLEROSIS JOURNAL 2015.5

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世界初の日本人肥厚性硬膜炎全国臨床疫学調査二次調査159例の解析結果報告

米川智, 村井弘之, 宇津木聡, 松下拓也, 眞崎勝久, 磯部紀子, 山崎亮, 吉田眞理, 楠進, 坂田清美, 藤井清孝, 吉良潤一

臨床神経学 2014.12

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多発性硬化症および視神経脊髄炎におけるT細胞受容体遺伝子領域のコピー数多型の同定

佐藤眞也, 山本健, 松下拓也, 磯部紀子, 河野祐治, 吉村怜, 飯沼今日子, 渡邉充, 米川智, 眞崎勝久, 山崎亮, 吉良潤一, the Japan Multiple Sclerosis Genetics Consortium

臨床神経学 2014.12

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Deletion-Type Copy Number Variations at T Cell Receptor Genes Confer Susceptibility to Multiple Sclerosis and Neuromyelitis Optica

Shinya Sato, Ken Yamamoto, Takuya Matsushita, Noriko Isobe, Yuji Kawano, Kyoko Iinuma, Tomomi Yonekawa, Katsuhisa Masaki, Satoshi Yoshimura, Ryo Yamasaki, Junichi Kira

ANNALS OF NEUROLOGY 2014.10

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Copy number variations in T cell receptor loci are associated with susceptibility to multiple sclerosis and neuromyelitis optica

Shinya Sato, Ken Yamamoto, Takuya Matsushita, Noriko Isobe, Yuji Kawano, Kyoko Iinuma, Tomomi Yonekawa, Katsuhisa Masaki, Satoshi Yoshimura, Ryo Yamasaki, Jun-ichi Kira

JOURNAL OF NEUROIMMUNOLOGY 2014.10

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DOI： 10.1016/j.jneuroim.2014.08.140
A genome-wide copy number variation study identified T-cell receptor as a susceptibility gene for multiple sclerosis and neuromyelitis optica

S. Sato, K. Yamamoto, T. Matsushita, N. Isobe, Y. Kawano, K. Iinuma, T. Yonekawa, K. Masaki, S. Yoshimura, R. Yamasaki, J-I Kira

MULTIPLE SCLEROSIS JOURNAL 2014.9

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Interleukin 2 Receptor Alpha Chain Gene Polymorphisms and Risk of Multiple Sclerosis and Neuromyelitis Optica

G. Ainiding, Y. Kawano, S. Sato, N. Isobe, T. Matsushita, S. Yoshimura, T. Yonekawa, R. Yamasaki, J. Kira

MULTIPLE SCLEROSIS JOURNAL 2014.6

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Cytokine Receptor Expression in Monocyte Subsets in Multiple Sclerosis, Neuromyelitis Optica, and Amyotrophic Lateral Sclerosis

Yi Wen Cui, Yuji Kawano, Nan Shi, Katsuhisa Masaki, Noriko Isobe, Tomomi Yonekawa, Takuya Matsushita, Takahisa Tateishi, Ryo Yamasaki, Jun-ichi Kira

MULTIPLE SCLEROSIS JOURNAL 2014.6

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Genetic studies of multiple sclerosis and neuromyelitis optica Current status in European, African American and Asian populations Reviewed

Noriko Isobe, Jorge R. Oksenberg

Clinical and Experimental Neuroimmunology 2014.1

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DOI： 10.1111/cen3.12078
Bacterial infectious burden and prevalence of idiopathic central nervous system demyelinating diseases in Japanese

Satoshi Yoshimura, Tomomi Yonekawa, Noriko Isobe, Takuya Matsushita, Jun-Ichi Kira

Clinical and Experimental Neuroimmunology 2013.12

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DOI： 10.1111/cen3.12047
3テスラMRIによる脱髄疾患における脊髄大長病変の軸位断での病変分布と進展形式の検討

米川智, 真崎勝久, 佐藤眞也, 磯部紀子, 松下拓也, 吉良潤一

臨床神経学 2013.12

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日本人多発性硬化症の緩徐進行群と非緩徐進行群の臨床・免疫遺伝学的背景の比較

渡邉充, 吉村怜, 磯部紀子, 米川智, 松下拓也, 佐藤眞也, 真崎勝久, 山崎亮, 河野祐治, 吉良潤一

臨床神経学 2013.12

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多発性硬化症および視神経脊髄炎における全ゲノムコピー数多型解析

佐藤眞也, 山本健, 河野祐治, 松下拓也, 磯部紀子, 渡邉充, 米川智, 真崎勝久, 吉良潤一, The South Japan Multiple Sclerosis Genetics Consortium

臨床神経学 2013.12

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IL-2受容体α鎖の遺伝子多型の日本人多発性硬化症における意義

Gulibahaer Ainiding, 河野祐治, 吉村怜, 渡邉充, 今村志穂子, 米川智, 真崎勝久, 磯部紀子, 松下拓也, 山崎亮, 吉良潤一

臨床神経学 2013.12

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視神経脊髄炎におけるT細胞受容体遺伝子のコピー数多型と表現型との関連

佐藤眞也, 松下拓也, 磯部紀子, 河野祐治, 渡邉充, 米川智, 真崎勝久, 山崎亮, 山本健, 吉良潤一

神経免疫学 2013.11

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Multimodality evoked potentials for discrimination of atopic myelitis and multiple sclerosis

Yuji Kanamori, Noriko Isobe, Tomomi Yonekawa, Takuya Matsushita, Hiroshi Shigeto, Nobutoshi Kawamura, Ryo Yamasaki, Hiroyuki Murai, Shozo Tobimatsu, Jun-Ichi Kira

Clinical and Experimental Neuroimmunology 2013.6

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DOI： 10.1111/cen3.12018
Reappraisal of longitudinally extensive spinal cord lesions by 3 tesla MRI in anti-AQP4 antibody-seropositive and -seronegative NMO and MS patients

Tomomi Yonekawa, Katsuhisa Masaki, Noriko Isobe, Satoshi Yoshimura, Takuya Matsushita, Jun-ichi Kira

MULTIPLE SCLEROSIS JOURNAL 2013.4

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多発性硬化症、視神経脊髄炎、Balo病における広汎なコネキシン脱落と病態への関与

真崎勝久, 鈴木諭, 松下拓也, 松岡健, 米川智, 磯部紀子, 田平武, 岩城徹, 吉良潤一

臨床神経学 2012.12

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日本人脱髄性疾患に影響する遺伝的要因と環境中の普遍的な感染性要因の同定

吉村怜, 磯部紀子, 米川智, 佐藤眞也, 真崎勝久, 松下拓也, 吉良潤一

臨床神経学 2012.12

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日本人多発性硬化症におけるNOTCH4ミスセンス変異とHLA Class2との相互作用

黄堅, 吉村怜, 磯部紀子, 松下拓也, 米川智, 吉良潤一

臨床神経学 2012.12

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日本人アトピー性脊髄炎患者のヒト白血球抗原における疾患感受性遺伝子の探索

佐藤眞也, 米川智, 眞崎勝久, 金森祐治, 吉村怜, 磯部紀子, 松下拓也, 吉良潤一

臨床神経学 2012.12

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Distinct HLA polymorphisms among atopic myelitis, multiple sclerosis and neuromyelitis optica patients in Japan

S. Sato, N. Isobe, S. Yoshimura, Y. Kanamori, K. Masaki, T. Matsushita, J-I. Kira

MULTIPLE SCLEROSIS JOURNAL 2012.10

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MS 日本人多発性硬化症でも髄液IgG産生異常は、HLA-DRB1*1501とBarkhof基準を満たす脳MRI病巣に有意に相関する

吉村怜, 磯部紀子, 米川智, 佐藤眞也, 眞崎勝久, 松下拓也, 吉良潤一

日本神経免疫学会学術集会抄録集 2012.9

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多発性硬化症、視神経脊髄炎、アトピー性脊髄炎のHLA遺伝子多型の差異

佐藤眞也, 吉村怜, 米川智, 磯部紀子, 金森祐治, 眞崎勝久, 松下拓也, 吉良潤一

日本神経免疫学会学術集会抄録集 2012.9

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疾患関連遺伝子日本人脱髄性疾患の疾患関連遺伝子

吉村怜, 磯部紀子, 松下拓也, 吉良潤一

日本臨床免疫学会会誌 2012.8

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The IL-7RA Polymorphism rs6897932 only confers MS Susceptibility in Japanese when it interacts with HLA-DRB1*0405

S. Yoshimura, N. Isobe, L. Fang, T. Matsushita, T. Yonekawa, K. Masaki, J. Kira

MULTIPLE SCLEROSIS JOURNAL 2012.4

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A NOTCH4 Missense Mutation Contributes to Resistance to Multiple Sclerosis in Japanese

N. Isobe, J. Huang, S. Yoshimura, T. Matsushita, T. Yonekawa, J. P. McElroy, S. L. Hauser, J. R. Oksenberg, J. Kira

MULTIPLE SCLEROSIS JOURNAL 2012.4

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An Increase in Japanese Multiple Sclerosis Patients with the Susceptibility Allele HLA-DRB1*0405 showing an Early Onset, Benign Course

S. Yoshimura, N. Isobe, T. Matsushita, T. Yonekawa, K. Masaki, J. Kira

MULTIPLE SCLEROSIS JOURNAL 2012.4

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Common Protective and Distinct Susceptibility HLA Class II Alleles in Neuromyelitis Optica and Multiple Sclerosis in Japanese According to Anti-AQP4 Antibody Status

N. Isobe, S. Yoshimura, T. Matsushita, T. Yonekawa, K. Masaki, J. Kira

MULTIPLE SCLEROSIS JOURNAL 2012.4

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Genetic Background for Recent Increase of MS in Japanese

N. Isobe, J. Kira

MULTIPLE SCLEROSIS JOURNAL 2012.4

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Distinct Genetic and Infectious Profiles between Multiple Sclerosis and Neuromyelitis Optica in Japanese Patients

Satoshi Yoshimura, Tomomi Yonekawa, Noriko Isobe, Katsuhisa Masaki, Shinya Satou, Takuya Matsushita, Jun-ichi Kira

NEUROLOGY 2012.4

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日本人多発性硬化症の遺伝的要因と環境要因の相互作用

吉村怜, 米川智, 磯部紀子, 眞崎勝久, 佐藤眞也, 松下拓也, 吉良潤一

日本内科学会雑誌 2012.2

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Multiple sclerosis Reviewed

Sreeram Ramagopalan, David Dyment, Rachel Farrell, Noriko Isobe

Autoimmune Diseases 2011.12

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DOI： 10.4061/2011/248758
Balo病における抗AQP4抗体非依存性コネキシンアストロサイトパチー

真崎勝久, 鈴木諭, 松岡健, 米川智, 磯部紀子, 松下拓也, 岩城徹, 吉良潤一

臨床神経学 2011.12

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視神経脊髄炎(NMO)における抗アクアポリン4(AQP4)I抗体の新しい定量的測定法の検討

米川智, 真崎勝久, 磯部紀子, 松下拓也, 吉良潤一, Shu Chen, Smith Bernard, Furmaniak Jadwiga

臨床神経学 2011.12

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日本人多発性硬化症(MS)患者におけるinterleukin-7 receptor alpha(IL-7RA)遺伝子多型の影響とHLAとの相互作用

吉村怜, 方楽, 磯部紀子, 米川智, 松下拓也, 真崎勝久, 土井光, 吉良潤一

臨床神経学 2011.12

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Reappraisal of longitudinally extensive spinal cord lesions by 3-Tesla MRI in anti-AQP4 antibody-seropositive and-seronegative NMO and MS patients

T. Yonekawa, K. Masaki, N. Isobe, S. Yoshimura, T. Matsushita, J. Kira

MULTIPLE SCLEROSIS JOURNAL 2011.10

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Interaction of the IL-7RA polymorphism rs6897932 and HLA-DRB1*0405 in Japanese multiple sclerosis patients

S. Yoshimura, T. Matsushita, N. Isobe, T. Yonekawa, K. Masaki, J. -I. Kira

MULTIPLE SCLEROSIS JOURNAL 2011.10

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Common and distinct associations of HLA-DRB1 and-DPB1 alleles with anti-AQP4 antibody-seropositive NMO/NMOSD, -seronegative NMO/NMOSD, and non-NMO/NMOSD MS in Japanese

S. Yoshimura, T. Matsushita, N. Isobe, T. Yonekawa, K. Masaki, J-I. Kira

MULTIPLE SCLEROSIS JOURNAL 2011.10

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Distinct Features of Neuromyelitis Optica According to Anti-Aquaporin-4 Antibody IgG Subclass

Noriko Isobe, Tomomi Yonekawa, Takuya Matsushita, Yuji Kawano, Katsuhisa Masaki, Satoshi Yoshimura, Jun-ichi Kira

ANNALS OF NEUROLOGY 2011.10

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Increased CSF IL-17A, IL-6, CXCL8 and CXCL10 in patients with neuromyelitis optica at relapse and their clinical relevance

T. Matsushita, T. Tateishi, T. Yonekawa, N. Isobe, J. -I. Kira

MULTIPLE SCLEROSIS JOURNAL 2011.10

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Common and Distinct Associations of HLA-DRB1 and-DPB1 Alleles with Neuromyelitis Optica and Multiple Sclerosis in Japanese

Satoshi Yoshimura, Noriko Isobe, Takuya Matsushita, Tomomi Yonekawa, Katsuhisa Masaki, Jun-ichi Kira

ANNALS OF NEUROLOGY 2011.10

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IL-7受容体α鎖(IL-7RA)遺伝子多型はHLA-DRB1*0405と相互作用する場合にのみMSの疾患感受性を高める

吉村怜, 磯部紀子, 松下拓也, 方楽, 米川智, 真崎勝久, 吉良潤一

日本神経免疫学会学術集会抄録集 2011.9

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視神経脊髄炎における抗アクアポリン4抗体によるHLAクラスIIアリル頻度の差異および多発性硬化症との比較

松下拓也, 吉村怜, 磯部紀子, 米川智, 眞崎勝久, 吉良潤一, South Japan MS Genetic Consortium

日本神経免疫学会学術集会抄録集 2011.9

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視神経脊髄炎(NMO)と多発性硬化症(MS)における長大な脊髄病巣の3テスラMRIによる解析

米川智, 真崎勝久, 磯部紀子, 吉村怜, 松下拓也, 吉良潤一

日本神経免疫学会学術集会抄録集 2011.9

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日本人多発性硬化症(MS)患者の増加は軽症のHLA-DRB1*0405アリル保有MS患者の増加による

吉村怜, 磯部紀子, 松下拓也, 米川智, 真崎勝久, 吉良潤一

日本神経免疫学会学術集会抄録集 2011.9

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免疫が関与する神経疾患脊髄初発多発性硬化症との比較に基づくアトピー性脊髄炎新診断基準の作成と検証

磯部紀子, 金森祐治, 米川智, 松下拓也, 重藤寛史, 河村信利, 吉良潤一

日本神経免疫学会学術集会抄録集 2011.9

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アトピー性脊髄炎と多発性硬化症の誘発電位検査所見の比較

金森祐治, 磯部紀子, 米川智, 松下拓也, 重藤寛史, 河村信利, 飛松省三, 吉良潤一

日本神経免疫学会学術集会抄録集 2011.9

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アトピー性脊髄炎におけるGP IIb/IIIa依存性血小板機能の検討

アイニディン・グリバハル, 山下謙一郎, 鳥居孝子, 古田興之介, 磯部紀子, 松下拓也, 吉良潤一

日本神経免疫学会学術集会抄録集 2011.9

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Notch4ミスセンス変異は日本人で多発性硬化症への疾患抵抗性を付与する

黄堅, 磯部紀子, 吉村怜, 松下拓也, 米川智, McElroy Joseph P., Hauser Stephen L., Oksenberg Jorge R., 吉良潤一

日本神経免疫学会学術集会抄録集 2011.9

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NMO-2 多発性硬化症・視神経脊髄炎における髄液サイトカイン・ケモカイン動態

松下拓也, 立石貴久, 米川智, 磯部紀子, 吉良潤一

日本神経免疫学会学術集会抄録集 2011.9

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NMO-1 抗アクアポリン4(AQP4)抗体IgG2サブクラス陽性者の臨床的特徴

磯部紀子, 米川智, 松下拓也, 河野祐治, 眞崎勝久, 吉村怜, 吉良潤一

日本神経免疫学会学術集会抄録集 2011.9

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MS 多発性硬化症、視神経脊髄炎、Balo病におけるコネキシンアストロサイトパチー

真崎勝久, 鈴木諭, 松岡健, 米川智, 磯部紀子, 松下拓也, 田平武, 岩城徹, 吉良潤一

日本神経免疫学会学術集会抄録集 2011.9

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Quantitative Assays for Anti-Aquaporin 4 Antibodies (AQP4Abs) in Neuromyelitis Optica (NMO)

Tomomi Yonekawa, Noriko Isobe, Takuya Matsushita, Yuji Kawano, Katsuhisa Masaki, Satoshi Yoshimura, Shu Chen, Bernard R. Smith, Jadwiga Furmaniak, Jun-ichi Kira

NEUROLOGY 2011.3

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Anti-AQP4 Antibody-Independent Astrocytopathy with Extensive Connexin Loss in Balo's Concentric Sclerosis and Allied Conditions

Katsuhisa Masaki, Takeshi Matsuoka, Satoshi O. Suzuki, Tomomi Yonekawa, Noriko Isobe, Takeshi Tabira, Toru Iwaki, Xiaomu Wu, Takuya Matsushita, Jun-ichi Kira

NEUROLOGY 2011.3

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MSおよびNMOにおける脳脊髄液中サイトカイン解析およびインターフェロンβによる影響

土井光, 松下拓也, 立石貴久, 磯部紀子, 吉良潤一

臨床神経学 2010.12

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頭部病巣の有無による再発寛解型視神経脊髄炎の臨床的特徴の比較

松下拓也, 磯部紀子, 松岡健, 真崎勝久, 米川智, 吉良潤一

臨床神経学 2010.12

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脱髄疾患におけるCLDND1の病理学的検討

真崎勝久, 三野原元澄, 米川智, 磯部紀子, 松下拓也, 吉良潤一

臨床神経学 2010.12

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アクアポリン4 M1、M23各イソフォームに対するNMO及びMS患者血清の反応性の検討

米川智, 磯部紀子, 真崎勝久, 松下拓也, 吉良潤一

臨床神経学 2010.12

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【MS(多発性硬化症)とNMO(視神経脊髄炎)】日本のMS、NMOの疫学的特徴全国臨床疫学調査の解析結果から

磯部紀子, 吉良潤一

2010.12

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Non-NMO MSとNMOにおけるHLA-DRB1アリル間のepistatic interaction解析

磯部紀子, 松下拓也, 松岡健, 米川智, 真崎勝久, Ramagopalan Sv, Ebers Gc, 西村泰治, 吉良潤一

臨床神経学 2010.12

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Extensive aquaporin 4 (AQP4) loss in Balo's concentric sclerosis in the absence of anti-AQP4 antibody

K. Masaki, T. Matsuoka, S. Suzuki, X. Wu, K. Zhang, T. Yonekawa, N. Isobe, A. Ordinario, T. Tabira, T. Iwaki, T. Matsushita, J. Kira

MULTIPLE SCLEROSIS 2010.10

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Cytokine and T helper cell profiles in multiple sclerosis

H. Doi, S. Y. Song, T. Matsushita, N. Isobe, K. Masaki, J. Kira

MULTIPLE SCLEROSIS 2010.10

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臨床医のための神経病理アトピー性脊髄炎

磯部紀子, 吉良潤一

2010.8

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特発性血小板減少性紫斑病に関連した多発単神経障害の1例

中村憲道, 重藤寛史, 磯部紀子, 田中正人, 大八木保政, 吉良潤一

臨床神経学 2010.7

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孤発性片麻痺性片頭痛を呈した全身性エリテマトーデスの1例

土井光, 立石貴久, 磯部紀子, 山崎亮, 大八木保政, 吉良潤一

臨床神経学 2010.5

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TTR質量分析および遺伝子検査が診断に有用であったFAP ATTR Ile107Valの1例

河村信利, 磯部紀子, 田中弘二, 大八木保政, 植田光晴, 安東由喜雄, 岩城徹, 吉良潤一

自律神経 2010.4

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Non-NMO MSとNMOにおけるHLA-DRB1アリル間のepistatic interaction解析

磯部紀子, 松下拓也, 松岡健, 米川智, 眞崎勝久, Ramagopalan SV, Ebers GC, 西村泰治, 吉良潤一

日本神経免疫学会学術集会抄録集 2010.3

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神経免疫実験モデル中枢神経系におけるCLDND1の発現と脱髄疾患への関与

真崎勝久, 三野原元澄, 米川智, 磯部紀子, 松下拓也, 吉良潤一

日本神経免疫学会学術集会抄録集 2010.3

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多発性硬化症における抗神経軸索抗体

磯部紀子, 吉良潤一

2010.3

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中枢神経障害を有するシェーグレン症候群と抗aquaporin-4(AQP4)抗体

松下拓也, 眞崎勝久, 米川智, 磯部紀子, 松岡健, 吉良潤一

日本神経免疫学会学術集会抄録集 2010.3

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The influence of HLA-DRB1 alleles on the susceptibility and resistance to multiple sclerosis with respect to the criteria of neuromyelitis optica

N. Isobe, T. Matsushita, R. Yamasaki, S. V. Ramagopalan, Y. Kawano, Y. Nishimura, G. C. Ebers, J. Kira

MULTIPLE SCLEROSIS 2010.2

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FACSの高感度化による抗AQP4抗体サブクラス解析の意義

河野祐治, 磯部紀子, 松下拓也, 松岡健, 河村信利, 三野原元澄, 吉良潤一, 三木哲郎

臨床神経学 2009.12

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抗アクアポリン4抗体陽性症例の再発期における高補体血症

土井光, 松下拓也, 磯部紀子, 松岡健, 三野原元澄, 越智博文, 吉良潤一

臨床神経学 2009.12

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抗aquaporin-4(AQP4)抗体陽性例におけるT細胞内・脳脊髄液中サイトカインの特徴

松下拓也, 磯部紀子, 松岡健, 史楠, 三野原元澄, 河野祐治, 吉良潤一

臨床神経学 2009.12

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多発性硬化症及びNMOにおけるBAFF及びAPRILの解析

岡田和将, 辻貞俊, 磯部紀子, 吉良潤一

臨床神経学 2009.12

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多発性硬化症(MS)におけるHLA-DRB1アリル間の相互作用の検討

磯部紀子, 松下拓也, 松岡健, 河野祐治, 三野原元澄, 吉良潤一

臨床神経学 2009.12

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ヘリコバクターピロリ感染による多発性硬化症の重症化

三野原元澄, 李巍, 松下拓也, 松岡健, 磯部紀子, 石津尚明, 吉良潤一

臨床神経学 2009.12

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TTR質量分析および遺伝子検査が診断に有用であったFAP ATTR Ile107Valの1例

河村信利, 磯部紀子, 田中弘二, 大八木保政, 植田光晴, 安東由喜雄, 岩城徹, 吉良潤一

日本自律神経学会総会プログラム・抄録集 2009.11

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Measurement of anti-aquaporin-4 antibody by a new flow cytometric assay and an enzyme-linked immunosorbent assay in comparison to a cell-based immunofluorescence assay

K. Masaki, T. Matsushita, N. Isobe, H. Une, T. Ishizu, Y. Kawano, J. I. Kira

MULTIPLE SCLEROSIS 2009.9

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Epistatic interactions at HLA-DRB1 in Japanese patients with multiple sclerosis

N. Isobe, T. Matsushita, R. Yamasaki, S. Ramagopalan, Y. Kawano, Y. Nishimura, G. Ebers, J. I. Kira

MULTIPLE SCLEROSIS 2009.9

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抗aquaporin-4抗体陽性の脳幹脳炎の1例

岩中行己男, 岡田和将, 魚住武則, 辻貞俊, 磯部紀子, 吉良潤一

臨床神経学 2009.4

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FACSを用いた高感度抗AQP4抗体の検出サブクラス解析を含めて

磯部紀子, 河野祐治, 松下拓也, 松岡健, 河村信利, 三野原元澄, 吉良潤一

神経免疫学 2009.3

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抗aquaporin-4(AQP4)抗体陽性例における細胞内・脳脊髄液中サイトカインの特徴

松下拓也, 磯部紀子, 松岡健, 史楠, 三野原元澄, 河野祐治, 吉良潤一

神経免疫学 2009.3

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多発性硬化症におけるヘリコバクターピロリ感染の影響

三野原元澄, 李巍, 松下拓也, 松岡健, 磯部紀子, 吉良潤一

神経免疫学 2009.3

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多発性硬化症および抗アクアポリン4抗体陽性症例における補体系の検討

土井光, 松下拓也, 磯部紀子, 松岡健, 三野原元澄, 越智博文, 吉良潤一

神経免疫学 2009.3

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Hypercomplementemia at relapse in patients with anti-aquaporin-4 antibody

H. Doi, T. Matsushita, N. Isobe, T. Matsuoka, M. Minohara, H. Ochi, J. Kira

MULTIPLE SCLEROSIS 2009.1

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mdxマウスにおけるサイトカイン・ケモカインの動態解析と分子標的療法の開発

荒畑創, 田中正人, 立石貴久, 磯部紀子, 本村今日子, 大八木保政, 吉良潤一

臨床神経学 2008.12

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アトピー関連脊髄炎・末梢神経炎の全国臨床疫学調査結果

磯部紀子, 河野祐治, 河村信利, 三野原元澄, 吉良潤一

臨床神経学 2008.12

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アトピー関連末梢神経炎・脊髄炎の全国臨床疫学調査結果

磯部紀子, 河野祐治, 河村信利, 三野原元澄, 吉良潤一

末梢神経 2008.12

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Acute onset facial numbness Left idiopathic trigeminal sensory neuropathy

Noriko Kuroki, Yasumasa Ohyagi, Yuji Kawano, Takashi Yoshiura, Takayuki Taniwaki, Jun-ichi Kira

JOURNAL OF CLINICAL NEUROSCIENCE 2008.9

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DOI： 10.1016/j.jocn.2007.08.016
【重症筋無力症-病態解明と診療の進歩】治療ガイドライン治療全体の流れ

磯部紀子, 吉良潤一

2008.9

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腎移植後にHTLV-1関連脊髄症(HAM)を発症し、特異な脳MRI所見を認めた一例

磯部紀子, 西口明子, 金ミエ, 立石貴久, 越智博文, 大八木保政, 吉良潤一

2008.9

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基礎疾患なく雷鳴頭痛とposterior reversible encephalopathy syndrome(PRES)を発症し、経過中可逆性の脳血管攣縮をみとめた1例

古賀優子, 磯部紀子[黒木], 立石貴久, 小副川学, 大八木保政, 吉良潤一

臨床神経学 2008.5

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脳炎、筋炎、その他アトピー関連脊髄炎・末梢神経炎の全国臨床疫学調査成績

磯部紀子, 河野祐治, 河村信利, 三野原元澄, 吉良潤一

神経免疫学 2008.4

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腎移植後にHTLV-1関連脊髄症(HAM)を発症し、特異な脳MRI所見を認め、薬剤性脳症の合併が疑われた1例

磯部紀子[黒木], 金ミエ, 立石貴久, 小副川学, 大八木保政, 吉良潤一

臨床神経学 2008.3

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Opticospinal multiple sclerosis in Japanese Reviewed

Jun-Ichi Kira, Takuya Matsushita, Noriko Isobe, Takaaki Ishizu

Neurology Asia 2008.1

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Professional Memberships

Japan Society for Dementia Research

2021.3 - Present

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Japan Society of Neurovegetative Research

2021.3 - Present

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The Japanese Society of Internal Medicine

2019.12 - Present

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American Academy of Neurology

2007 - Present

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日本難病医療ネットワーク学会評議員

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The Japanese Society for Neuroimmunology

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Japanese Society of Neurology

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Japanese Society of Neurological Therapeutics

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The Japan Stroke Society

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日本臨床免疫学会

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日本難病医療ネットワーク学会評議員
日本臨床免疫学会
日本難病医療ネットワーク学会評議員
日本臨床免疫学会
The Japanese Society of Internal Medicine
The Japan Stroke Society
Japanese Society of Neurological Therapeutics
American Academy of Neurology
The Japanese Society for Neuroimmunology
The Japanese Society for Neurology
Japan Society of Neurovegetative Research
Japan Society for Dementia Research
The Japanese Society of Internal Medicine
American Academy of Neurology
The Japanese Society for Neuroimmunology
Japanese Society of Neurology
Japanese Society of Neurological Therapeutics
The Japan Stroke Society

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Committee Memberships

日本神経学会学術大会教育プログラム小委員会

2023.6 - 2025.6

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Committee type：Academic society

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Executive Domestic

2022.10 - Present
日本神経学会国際対応委員会委員

2021.9 - Present

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Committee type：Academic society

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Japanese Society of Neurology Pediatric-Adult Transition Medical Measures Special Committee

2021.7 - Present

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Committee type：Academic society

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Japanese Society of Neurology Specialist system steering committee member

2021.5 - Present

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Committee type：Academic society

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日本神経学会専門医制度運営委員会 Domestic

2021.5 - Present
Councilor Domestic

2021.4 - Present
Japanese Society of Neurology Immune Neurological Disorders Section Section Core Members

2021.1 - Present

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The Japanese Society for Neuroimmunology Member of MS/NMOSD Committee

2020.11 - Present

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Committee type：Academic society

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Japanese Society of Neurology Vice-chair of Multiple Sclerosis & Neuromyelitis optica Clinical Practice Guideline Development Committee

2020.8 - Present

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Committee type：Academic society

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Councilor Domestic

2018.9 - Present
日本神経学会代議員

- Present

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Committee type：Academic society

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Pan-Asian Committee for Treatment and Research in Multiple Sclerosis (PACTRIMS) Scientific Programme Committee Chaiarperson

- Present

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International Society of Neuroimmunology advisory board

- Present

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Academic Activities

Screening of academic papers

Role(s)： Peer review

2021

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Type：Peer review

Number of peer-reviewed articles in foreign language journals：17

Number of peer-reviewed articles in Japanese journals：7

Research Projects

Elucidation of inflammation regulatory mechanisms in central nervous system autoimmune diseases

Grant number：24K02371 2024.4 - 2028.3

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)

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CiNii Research
CD20陽性T細胞とB細胞に注目した多発性硬化症病態の解明

Grant number：23K06964 2023 - 2025

日本学術振興会科学研究費助成事業基盤研究(C)

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免疫学的視点からみた中枢性神経障害性疼痛の病態解明ならびに新規治療法開発

Grant number：23K06945 2023 - 2025

日本学術振興会科学研究費助成事業基盤研究(C)

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CD20陽性T細胞とB細胞に注目した多発性硬化症病態の解明

Grant number：23K06964 2023 - 2025

日本学術振興会科学研究費助成事業基盤研究(C)

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免疫学的視点からみた中枢性神経障害性疼痛の病態解明ならびに新規治療法開発

Grant number：23K06945 2023 - 2025

日本学術振興会科学研究費助成事業基盤研究(C)

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中枢神経炎症性疾患の治療を遺伝・免疫・血清学的指標を用いて最適化する方法の確立

Grant number：22K07351 2022.4 - 2025.3

科学研究費助成事業基盤研究(C)

渡邉充, 松下拓也, 吉良潤一, 磯部紀子, Maimaitijiang Guzailiayi

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中枢神経系の炎症性疾患である多発性硬化症および視神経脊髄炎スペクトラム障害は、いずれも適切な治療を行わないと将来身体機能障害や認知機能障害を来たす疾患である。近年様々な薬剤が使用できるようになってきているが、患者ごとに経過や治療反応性が異なるとともに、最適な治療薬を選択する指標は存在しない。そこで本研究では、患者の遺伝学的・免疫学的背景、疾患の活動性のバイオマーカー指標を総合的に評価し、どの治療薬を選択することが最適かを患者ごとに判断できるようになることを目的とする。これにより患者の長期予後を改善させ、過度な治療による不要なリスクを避け、さらには医療経済への負担も軽減させることが期待される。

CiNii Research
新規発見ノド抗体による自己免疫性ノドパチーの中枢及び末梢神経脱髄機序の解明と治療

Grant number：22H02985 2022 - 2024

日本学術振興会科学研究費助成事業基盤研究(C)

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研究活動への支援／視神経脊髄炎スペクトラム障害の病態解明

2022

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Grant type：Donation
持続可能な医療体制にむけた医療職の多様な働き方に関する国際的調査研究への展開

Grant number：21K18462 2021.7 - 2024.3

科学研究費助成事業挑戦的研究(萌芽)

樗木晶子, 加藤聖子, 澤渡浩之, 錦谷まりこ, 工藤孔梨子, 中島直樹, 磯部紀子, 川波祥子, 樗木浩朗, 伊豆倉理江子, 永吉絹子

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Grant type：Scientific research funding

文化的背景の異なる海外施設において医療職の現状や労働環境に関する調査を展開し, 異なる文化・社会の国々における現状を, 代表者が行ってきた本邦の10年間の医療職の労働環境や健康に対する意識調査の結果と比較し,グローバルな視点から打開策を構築することを目的として主に下記の３つのプロジェクトを遂行する。
1）海外医療施設で労働環境や健康に関する独自の質問票調査を展開し, 次ぎに, 2) 異なる文化・社会の国々における連携施設と医療職の現状を共有するためにウエブ上でワークショップや講演会を開催し, 最後に, 3) 現地での現状調査などを行い本邦における医療職の働きやすい環境の構築に向けた方策を検討する。
 

CiNii Research
中枢神経系自己免疫性疾患における性染色体とHLAの相互的な病態寄与機構の解明

Grant number：21K07464 2021 - 2023

日本学術振興会科学研究費助成事業基盤研究(C)

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中枢神経系自己免疫性疾患における性染色体とHLAの相互的な病態寄与機構の解明

Grant number：21K07464 2021 - 2023

日本学術振興会科学研究費助成事業基盤研究(C)

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Authorship：Principal investigator Grant type：Scientific research funding
（雇用支援）

2021

九州大学研究活動基礎支援制度　研究補助者雇用支援（短期）

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Authorship：Principal investigator Grant type：On-campus funds, funds, etc.
Novel therapy for spinal cord damage of neuromyelitis optica via regulation of BK channel

Grant number：20K07869 2020.4 - 2023.3

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

Matsushita Takuya

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We investigated associations between KCNMA1, a component of BK channel, and spinal cord damage in patients with neuromyelitis optic spectrum disorders (NMOSD). Immunoreactivity in the perivascular area of the central gray matter, where aquaporin-4 (AQP4), an antigen targeted by specific autoantibodies in NMOSD, is observed. Primary astrocyte cultures exhibited KCNMA1 expression in the membrane similar to AQP4, as well as in the perikaryon. These astrocytes were damaged to death by addition of IgG purified from serum of a NMOSD patient with anti-AQP4 antibody and complements. Addition of modulator of KCNMA1, ISO or PAX , did not elicit any effects on IgG-complement-mediated damage .However, NMO-IgG addition to the cells induced translocation of NFκB into the nucleus and the translocation was inhibited by ISO and accelerated by PAX addition. These findings suggest that KCNMA1 influences CNS inflammation by promoting astrocytes to adopt a pro-inflammatory phenotype.

CiNii Research
（雇用支援）

2020

九州大学研究活動基礎支援制度　研究補助者雇用支援（短期）

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Authorship：Principal investigator Grant type：On-campus funds, funds, etc.
（雇用支援）

2019

九州大学研究活動基礎支援制度　研究補助者雇用支援（短期）

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Authorship：Principal investigator Grant type：On-campus funds, funds, etc.
アリルの片親起源効果を考慮した多発性硬化症リスク遺伝子の新規同定と寄与機構の解明

Grant number：18K07529 2018 - 2020

日本学術振興会科学研究費助成事業基盤研究(C)

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Authorship：Principal investigator Grant type：Scientific research funding
アリルの片親起源効果を考慮した多発性硬化症リスク遺伝子の新規同定と寄与機構の解明

Grant number：18K07529 2018 - 2020

日本学術振興会科学研究費助成事業基盤研究(C)

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Grant type：Scientific research funding
（雇用支援）

2018

九州大学研究活動基礎支援制度　研究補助者雇用支援（短期）

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Authorship：Principal investigator Grant type：On-campus funds, funds, etc.
（派遣支援）

2018

九州大学研究活動基礎支援制度国際学会派遣支援

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Authorship：Principal investigator Grant type：On-campus funds, funds, etc.
パスウェイバーデン解析に基づく多発性硬化症リスク遺伝子の疾患多様性への寄与の解明

Grant number：17H06938 2017 - 2018

日本学術振興会科学研究費助成事業基盤研究(C)

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Grant type：Scientific research funding
パスウェイバーデン解析に基づく多発性硬化症リスク遺伝子の疾患多様性への寄与機構の解明

2017 - 2018

日本学術振興会科学研究費助成事業基盤研究(C)

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Authorship：Principal investigator Grant type：Scientific research funding
パスウェイバーデン解析に基づく多発性硬化症リスク遺伝子の疾患多様性への寄与の解明

Grant number：17H06938 2017

日本学術振興会科学研究費助成事業研究活動スタート支援

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Authorship：Principal investigator Grant type：Scientific research funding
（雇用支援）

2017

九州大学研究活動基礎支援制度　研究補助者雇用支援（短期）

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Authorship：Principal investigator Grant type：On-campus funds, funds, etc.
中枢神経系自己免疫性疾患における遺伝的疾患感受性因子の同定

2017

九州大学研究活動基礎支援制度　出産・育児復帰者支援（短期）

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Authorship：Principal investigator Grant type：On-campus funds, funds, etc.
脱髄性神経疾患における疾患感受性および病態進行に関わる遺伝学的要因の解明

Grant number：14J03139 2014 - 2015

日本学術振興会科学研究費助成事業基盤研究(C)

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Grant type：Scientific research funding
多発性硬化症疾患感受性遺伝子の病態進行に対する影響

2014 - 2015

日本学術振興会特別研究員

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Authorship：Principal investigator Grant type：Joint research
多発性硬化症疾患感受性遺伝子の病態進行に対する影響

2012 - 2013

日本学術振興会海外特別研究員

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Authorship：Principal investigator Grant type：Joint research
多発性硬化症における疾患関連遺伝子の解明

2011

上原記念生命科学財団海外留学助成金ポストドクトラルフェローシップ

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Authorship：Principal investigator Grant type：Contract research
遺伝環境リスクと病態特異的抗神経分子抗体に基づく脱髄疾患の自己免疫機構解明と治療

Grant number：19H01045

吉良潤一, 松下拓也, 山崎亮, 藤井敬之, 緒方英紀, 磯部紀子, 萬谷博, 海田賢一, 渡邉充, 中村優理

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Grant type：Scientific research funding

慢性脱髄疾患として中枢神経を侵す多発性硬化症(MS)と末梢神経を侵す慢性炎症性脱髄性多発神経炎(CIDP)が代表的である。私達は神経根肥厚を呈するCIDPで、IgG4抗NF155抗体が陽性で、全例がMSのリスク遺伝子と同じHLA-DRB1*15を保有することを発見した。また、MS類縁疾患のアトピー性脊髄炎で抗Plexin D1抗体が陽性であることを見出した。MSの環境リスクとしてピロリ菌感染や米食の減少を同定した。本研究では慢性脱髄疾患を対象とし遺伝環境リスクを背景に病態特異的自己抗体の産生を伴う自己免疫が成立する過程を解明し、病態バイオマーカーの確立とモデル動物作成による新規治療開発を行う。

CiNii Research
新規同定環境リスク因子に基づいたウルチ米アミロースによる多発性硬化症の画期的治療

Grant number：19K07995

渡邉充, 山崎亮, 磯部紀子, 松下拓也, 中村優理

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Grant type：Scientific research funding

多発性硬化症(MS)は原因不明の炎症性脱髄性中枢神経疾患である。疾患修飾薬によりある程度の再発予防が可能になったものの、未だ根治はできず、詳しい病態解明が望まれている。私たちはこれまでMS発症に関連する環境要因を調査する研究を行ってきた。食生活に関するアンケート調査により、日本人MS患者では米の摂取量が少ないことを見出し、米食の減少がMSの発症を増やす環境リスクである可能性を見出した。そこで本研究では、米食による免疫機能の変化、MS発症を予防する機序を、患者を対象とした臨床研究と実験モデルマウスを用いた動物実験により明らかにし、新たな視点からのMSの病態解明、新規治療法の開発を目指す。

CiNii Research
日本人多発性硬化症での疾患修飾薬による進行性多巣性白質脳症多発機序の解明と防止

Grant number：19K07997

河野祐治, 松下拓也, 渡邉充, 中村優理, 磯部紀子

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Grant type：Scientific research funding

多発性硬化症(MS)は、疾患修飾薬により再発を減らすことが可能になったが、重大な副作用として長期使用に伴い潜伏感染しているJC virus (JCV)が起こす進行性多巣性白質脳症(PML)がある。特に日本人では欧米人の約10倍のPML発症がみられ、大きな問題になっている。本研究ではPML発症が多い理由の解明、PML発症リスク因子の同定と発症予測バイオマーカーの確立を目的とする。そのため、全ゲノム関連解析によるJCV感染の感受性遺伝子の同定、HLA多型とJCV特異的T細胞(CD8/CD4)の頻度及びT細胞の認識するJCV抗原エピトープの同定、疾患修飾薬によるこれらの変化等を解析する。

CiNii Research

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Class subject

神経

2023.10 - 2024.3 Second semester
生命医科学研究入門

2023.10 - 2024.3 Second semester
老年病学

2023.10 - 2024.3 Second semester
遺伝学

2023.10 - 2024.3 Second semester
神経診察

2023.4 - 2023.9 First semester
生命医科学研究入門

2022.10 - 2023.3 Second semester
神経

2022.10 - 2023.3 Second semester
老年病学

2022.10 - 2023.3 Second semester
遺伝学

2022.10 - 2023.3 Second semester
神経診察（診療参加型臨床実習に必要な技能と態度）

2022.4 - 2022.9 First semester
生命の科学A

2022.4 - 2022.9 First semester
神経診察（診療参加型臨床実習に必要な技能と態度）

2021.10 - 2022.3 Second semester
神経

2021.10 - 2022.3 Second semester
老年病学

2021.10 - 2022.3 Second semester
免疫学

2021.4 - 2021.9 First semester
神経

2020.10 - 2021.3 Second semester
神経

2019.10 - 2020.3 Second semester

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FD Participation

2021.4 Role：Participation Title：令和３年度第１回全学ＦＤ（新任教員の研修）

Organizer：University-wide

Participation in international educational events, etc.

2017.6

Department of Neurology, Kyushu University; Telemedicine Development Center of Asia (TEMDEC), Kyushu University; Universitas Indonesia, et al.

The 4th Indonesian Neurology NMO Case Teleconference

Outline of Social Contribution and International Cooperation activities

As a facilitator at Kyushu University, I have been working for regular web case conferences with 7 Departments of Neurology in Indonesian Universities and Hospitals for intractable cases with neuroloimmunological diseases.

Social Activities

多発性硬化症の治療：再発と進行を抑えるために

Role(s)： Lecturer

認定NPO法人日本多発性硬化症協会第13回市民公開講演会 2024.3

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Type：Lecture

researchmap
Opening the doors for opportunity

Role(s)： Contribution

Nature Portfolio Women in Neuroimmunology 2024.3 - Present

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Type：Newspaper, magazine

researchmap
Opening the doors for opportunity

Nature Portfolio 2024.3

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Audience： General,　Scientific,　Company,　Civic organization,　Governmental agency
Opening the doors for opportunity

Nature Portfolio 2024.3

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Audience： General,　Scientific,　Company,　Civic organization,　Governmental agency
脳を守るバリア：血液脳関門

Role(s)： Contribution

日本脳科学関連学会連合知ってなるほど！脳科学豆知識 2023.10 - Present

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Type：Internet

researchmap
脳を守るバリア：血液脳関門

日本脳科学関連学会連合 2023.10

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Audience： General,　Scientific,　Company,　Civic organization,　Governmental agency
医師という働き方

福岡県保健医療介護部医療指導課医師・看護職員確保対策室医師確保班未来の女性医師発掘事業 2023.10

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Audience： General,　Scientific,　Company,　Civic organization,　Governmental agency
脳を守るバリア：血液脳関門

日本脳科学関連学会連合 2023.10

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Audience： General,　Scientific,　Company,　Civic organization,　Governmental agency
医師という働き方

福岡県保健医療介護部医療指導課医師・看護職員確保対策室医師確保班未来の女性医師発掘事業 2023.10

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Audience： General,　Scientific,　Company,　Civic organization,　Governmental agency
医進・サイエンスコース探究活動／神経難病の克服に向けて②

筑紫女学園中学校 2023.5

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Audience： Infants,　Schoolchildren,　Junior students,　High school students

Type：Seminar, workshop
神経難病の克服に向けて

Role(s)： Lecturer

筑紫女学園中学校医進・サイエンスコース探究活動 2023.4 - 2023.5

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Type：Visiting lecture

researchmap
神経難病の克服に向けて

筑紫女学園中学校 2023.4

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Audience： General,　Scientific,　Company,　Civic organization,　Governmental agency
医進・サイエンスコース探究活動／神経難病の克服に向けて①

筑紫女学園中学校 2023.4

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Audience： Infants,　Schoolchildren,　Junior students,　High school students

Type：Seminar, workshop
認定NPO法人日本多発性硬化症協会主催の第13回市民公開講演会において、「多発性硬化症の治療：再発と進行を抑えるために」というタイトルで基調講演を行った。（2024/3/10、東京・ハイブリッド開催）

2023

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認定NPO法人日本多発性硬化症協会主催の第13回市民公開講演会において、「多発性硬化症の治療：再発と進行を抑えるために」というタイトルで基調講演を行った。（2024/3/10、東京・ハイブリッド開催）
福岡県保健医療介護部医療指導課医師・看護職員確保対策室医師確保班の未来の女性医師発掘事業の一環として、福岡大学附属大濠高等学校・中学校の生徒を対象に、「医師という働き方」という演題で講演を行った。（2023/10/7）

2023

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福岡県保健医療介護部医療指導課医師・看護職員確保対策室医師確保班の未来の女性医師発掘事業の一環として、福岡大学附属大濠高等学校・中学校の生徒を対象に、「医師という働き方」という演題で講演を行った。（2023/10/7）
日本脳科学関連学会連合ウェブサイト上の企画「知ってなるほど！脳科学豆知識」コーナーにおいて、「脳を守るバリア：血液脳関門」について寄稿した。（2023/10）

2023

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日本脳科学関連学会連合ウェブサイト上の企画「知ってなるほど！脳科学豆知識」コーナーにおいて、「脳を守るバリア：血液脳関門」について寄稿した。（2023/10）
医師という働き方

福岡県保健医療介護部医療指導課医師・看護職員確保対策室医師確保班 2022.9

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Audience： General,　Scientific,　Company,　Civic organization,　Governmental agency
第63回日本神経学会学術大会市民公開講座　健康脳への挑戦　ここまでわかった神経免疫　「多発性硬化症の治療と生活」

日本神経学会 JPタワー　ホール＆カンファレンス（東京） 2022.5

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Audience： General,　Scientific,　Company,　Civic organization,　Governmental agency

Type：Lecture
福岡県保健医療介護部医療指導課医師・看護職員確保対策室医師確保班の未来の女性医師発掘事業の一環として、筑紫女学園高等学校・中学校の生徒を対象に、「医師という働き方」という演題で講演を行った。（2022/9/21）

2022

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福岡県保健医療介護部医療指導課医師・看護職員確保対策室医師確保班の未来の女性医師発掘事業の一環として、筑紫女学園高等学校・中学校の生徒を対象に、「医師という働き方」という演題で講演を行った。（2022/9/21）
第63回日本神経学会学術大会市民公開講座において「健康脳への挑戦～ここまでわかった神経免疫～」というタイトルで市民向け講演を行った。（2022/5/22、東京）

2022

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第63回日本神経学会学術大会市民公開講座において「健康脳への挑戦～ここまでわかった神経免疫～」というタイトルで市民向け講演を行った。（2022/5/22、東京）
九州大学医師会市民公開講座にて「身近な脳神経内科～頭痛・しびれ・認知症～」という演題で市民向け講演を行った。（2023/3/17、Web開催）

2022

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九州大学医師会市民公開講座にて「身近な脳神経内科～頭痛・しびれ・認知症～」という演題で市民向け講演を行った。（2023/3/17、Web開催）
多発性硬化症（MS）Web市民公開講座　対話から見えてくること

主催　ノバルティスファーマ株式会社（協力：　NPO法人　MSキャビン、全国多発性硬化症友の会、認定NPO法人　日本多発性硬化症協会） 2021.12

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Audience： General,　Scientific,　Company,　Civic organization,　Governmental agency

Type：Lecture
医師という働き方

福岡県保健医療介護部医療指導課医師・看護職員確保対策室医師確保班 2021.9

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Audience： General,　Scientific,　Company,　Civic organization,　Governmental agency
講演　「医師という働き方」

福岡県保健医療介護部医療指導課医師・看護職員確保対策室医師確保班筑紫女学園（医進コース対象講演会） 2021.9

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Audience： General,　Scientific,　Company,　Civic organization,　Governmental agency

Type：Lecture
MSの最新治療を知る　「抗体治療と進行型MSの治療」

日本多発性硬化症ネットワーク 2021.5

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Audience： General,　Scientific,　Company,　Civic organization,　Governmental agency

Type：Other

一般の多発性硬化症（MS）患者向けにMSの最新の治療について対談形式で意見交換を行った。
福岡県保健医療介護部医療指導課医師・看護職員確保対策室医師確保班の未来の女性医師発掘事業の一環として、筑紫女学園高等学校・中学校の生徒を対象に、「医師という働き方」という演題で講演を行った。（2021/9/21）

2021

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福岡県保健医療介護部医療指導課医師・看護職員確保対策室医師確保班の未来の女性医師発掘事業の一環として、筑紫女学園高等学校・中学校の生徒を対象に、「医師という働き方」という演題で講演を行った。（2021/9/21）
医療の世界－医師という働き方－

福岡県保健医療介護部医療指導課医師・看護職員確保対策室医師確保班九州産業大学付属九州産業高等学校 2020.12

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Audience： General,　Scientific,　Company,　Civic organization,　Governmental agency
福岡県保健医療介護部医療指導課医師・看護職員確保対策室医師確保班の未来の女性医師発掘事業の一環として、九州産業大学付属産業高等学校の生徒を対象に、「医療の世界ー医師という働き方ー」という演題で講演を行った。（2020/12/16）

2020

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福岡県保健医療介護部医療指導課医師・看護職員確保対策室医師確保班の未来の女性医師発掘事業の一環として、九州産業大学付属産業高等学校の生徒を対象に、「医療の世界ー医師という働き方ー」という演題で講演を行った。（2020/12/16）

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Media Coverage

（いま子どもたちは）医の心、育む：３　グループ学習、「チーム医療みたい」 Newspaper, magazine

朝日新聞 2021.11

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（いま子どもたちは）医の心、育む：３　グループ学習、「チーム医療みたい」
（いま子どもたちは）医の心、育む：４　女性医師への道、ブレーキかけずに Newspaper, magazine

朝日新聞 2021.11

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（いま子どもたちは）医の心、育む：４　女性医師への道、ブレーキかけずに
多様性を尊重　新たな歴史を紡ぐ Newspaper, magazine

九州医事新報 2021.10

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多様性を尊重　新たな歴史を紡ぐ

Activities contributing to policy formation, academic promotion, etc.

2022.4 - Present 一般社団法人　九州大学医学部同窓会

同窓会誌「学士鍋」編集委員会　編集委員
2021.5 - Present 日本神経学会

専門医制度運営委員会
2021.5 - Present 日本内科学会

医療安全委員会委員
2021.5 - 2024.3 福岡市

福岡市保健福祉審議会委員
2021.4 - Present 福岡県

福岡県難病医療連絡協議会委員
2021.4 - 2023.3 福岡市

福岡市難病対策地域協議会委員
2021.3 - Present 日本神経学会

免疫性神経疾患セクションセクションコアメンバー
2020.11 - 2021.10 日本神経免疫学会

MS・NMOSD委員会委員
2020.11 - 2021.10 日本神経免疫学会

第33回日本神経免疫学会学術集会プログラム委員
2020.7 - Present 日本神経学会

多発性硬化症・視神経脊髄炎診療ガイドライン作成委員会2022副委員長

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Educational Activities for Highly-Specialized Professionals in Other Countries

2021.3 - 2021.7 多発性硬化症についての免疫学的検討

Main countries of student/trainee affiliation：China

Travel Abroad

2010.10 - 2017.3

Staying countory name 1：United States Staying institution name 1：Repartment of Neurology, University of California San Francisco
2009.1

Staying countory name 1：United Kingdom Staying institution name 1：Wellcome Trust Centre for Human Genetics and Department of Clinical Neurology, University of Oxford

Specialized clinical area

Biology / Medicine, Dentistry and Pharmacy / Internal Medicine / Neurology

Clinician qualification

Specialist

Japanese Society of Neurology
Specialist

The Japanese Society of Internal Medicine（JSIM）

Year of medical license acquisition

2003

Notable Clinical Activities

中枢神経自己免疫性疾患を中心とする神経免疫性疾患全般の診療、研究