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Language：English   Publisher：(一社)日本生理人類学会  

自己/他者識別に関連する認知と、ミラーシステム活動の指標であるmuリズム抑制との関連について検討した。健常大学生30例(男性22例、女性8例、平均年齢23.6±1.6歳)を被検者とし、被検者自身や他者の手の動きを撮影したビデオクリップを一人称視点および三人称視点で観察させ、ビデオクリップ観察中に脳波図(EEG)からmuリズムを測定した。また、自己検出に関連したEEG活動は、自己関連刺激として被験者自身の手の動きから解析した。その結果、8-13Hzにおけるmuリズム抑制は、自己および他者刺激に対し、視点に依存した応答性が観察された。なお、一人称視点では有意な自己指向性のmuリズム抑制応答が認められたが、三人称視点では有意な応答指向性はみられず、ミラーシステム活動には、視点に依存して異なる自己と他者の識別が含まれることが示唆された。以上より、自己および他者や視点の違いは、muリズム抑制に影響を及ぼすことが示された

Language：Japanese   Publisher：Faculty of Design, Kyushu University  

Geiko Expo started seven years ago. In this seventh meeting, seven new faculty members gave oral presentations. Faculty of Design, Kyushu University is characterized by its diverse areas of expertise and unique research. Several faculty members contributed to this event. This special issue is related to the content of this event and includes contributions from the presenters. A wide range of research is presented, from the arts to engineering to the human sciences.

DOI： 10.15017/7170262

CiNii Research

Language：Japanese   Publisher：Faculty of Design, Kyushu University  

GEIKO EXPO started eight years ago. In this eighth event, eight new faculty members gave oral presentations. Faculty of Design, Kyushu University is characterized by its diverse areas of expertise and unique research. Several faculty members contributed to this event. This special issue is related to the content of this event and includes contributions from the presenters. A wide range of research is presented, from the arts to engineering to the human sciences.

DOI： 10.15017/7343268

CiNii Research

Language：Others   Publisher：Clocks and Sleep  

Relationship between Circadian Phase Delay without Morning Light and Phase Advance by Bright Light Exposure the Following Morning

DOI： 10.3390/clockssleep5040041

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：Journal of Physiological Anthropology  

BACKGROUND: Alexithymia, a personality trait characterized by difficulties in identifying and expressing their emotions despite having a range of emotional experiences, can impact individuals' stress coping mechanisms. While many studies have investigated brain functions associated with specific tasks in relation to emotion processing, research focusing on resting-state brain functions has been limited. Thus, the aim of this study was to investigate the relationship between alexithymia and brain function by analyzing arterial spin labeling (ASL) data obtained during the resting state. METHODS: A brain structural and functional imaging study was conducted on 42 healthy adult men and women using ASL and the 20-item Toronto Alexithymia Scale (TAS-20) questionnaire survey. Cerebral blood flow and functional connectivity values were calculated for regions of interest in the default mode network, saliency network, and central executive network from the ASL data. Correlation analysis was performed with TAS20 scores, and partial correlation analysis was conducted to control for anxiety and depression. RESULTS: The functional connectivity analysis revealed a negative correlation between the functional connectivity of the right insular cortex and left anterior cingulate cortex and the total score of TAS, as well as difficulty identifying feelings and difficulty describing feeling subscores, indicating that the higher the scores, the weaker the functional connectivity between these regions (T = -3.830, p = 0.0013, R = -0.5180). This correlation remained significant even after controlling for anxiety and depression using partial correlation analysis. CONCLUSION: The present study revealed differences in the activity of the Saliency Network at rest as measured by ASL, which were independent of anxiety and depression, and varied depending on the severity of alexithymia. This functional change may underlie the neural basis of decreased emotional processing observed in alexithymia. These findings may contribute to the elucidation of the neural mechanisms of alexithymia, which can lead to social impairments, and suggest the usefulness of ASL measurement as a biomarker of alexithymia.

DOI： 10.1186/s40101-023-00336-1

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Language：Others   Publishing type：Research paper (scientific journal)   Publisher：Springer Science and Business Media LLC  

Abstract

Background

The aim of this study was to examine the effect of others’ gaze on an observer’s microsaccades. We also aimed to conduct preliminary investigations on the relationship between the microsaccadic response to a gaze and a gazer’s facial expression and attention-deficit/hyperactivity disorder (ADHD) tendencies.

Methods

Twenty healthy undergraduate and graduate students performed a peripheral target detection task by using unpredictable gaze cues. During the task, the participants’ eye movements, along with changes in pupil size and response times for target detection, were recorded. ADHD tendencies were determined using an ADHD questionnaire.

Results

We found that consciously perceiving the gaze of another person induced the observer’s attention; moreover, microsaccades were biased in the direction opposite to the gaze. Furthermore, these microsaccade biases were differentially modulated, based on the cognitive processing of the facial expressions of the gaze. Exploratory correlation analysis indicated that microsaccade biases toward gazes with fearful expressions may specifically be correlated with participant characteristics, including inattention.

Conclusions

Our findings support that microsaccades reflect spatial attention processing and social cognitive processing. Moreover, the exploratory correlation analysis results suggested the potential benefit of using microsaccade bias toward spatial attention to assess pathophysiological responses associated with ADHD tendencies.

DOI： 10.1186/s40101-023-00335-2

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Other Link： https://link.springer.com/article/10.1186/s40101-023-00335-2/fulltext.html

Language：English   Publisher：(一社)日本生理人類学会  

失感情症と脳機能の関係について安静時に取得した動脈スピンラベリング(ASL)データの解析による検討を行った。健常成人42人(男性14人、女性28人、平均31.2±9.5歳)を対象として、ASLと20-item Toronto Alexithymia Scale(TAS-20)アンケート調査を用いて脳の構造及び機能イメージング研究を行った。ASLデータから、デフォルトモードネットワーク、salience network及びセントラルエグゼクティブネットワークにおける関心領域に対する脳血流及び機能的結合の値を算出した。機能的結合分析により、右島皮質及び左前帯状皮質の機能的結合と、TAS-20のトータルスコア、感情を特定することの困難さ、感情を語ることの困難さのサブスコアに負の相関がみられた。これらのスコアが高いほどこれらの領域間の機能的結合は弱くなった。この相関は偏相関分析を用いて不安及び抑鬱を調整した後でも有意であった。

Language：English   Publisher：(一社)日本生理人類学会  

注意欠如多動症(ADHD)傾向のバイオマーカーとしてのマイクロサッカードの有用性について検討した。大学生及び大学院生20人(全員男性、平均22.9±0.9歳)を対象に、予測不可能な視線手掛かりを用いた周辺標的検出課題を行った。課題時における被験者の標的検出のための眼の動きを瞳孔サイズの変化及び反応時間とともに記録した。ADHD傾向はADHDアンケートを用いて調べた。他者の視線を意識的に知覚することにより観察者の注意が誘導され、マイクロサッカードは視線とは反対方向に偏っていた。これらのマイクロサッカードの偏りは顔の表情の認知処理に基づいて特異的に調節された。探索的な相関分析により、恐怖の表情を伴った視線へのマイクロサッカードの偏りは、不注意を含む被験者の特性と特異的に相関すると考えられた。以上より、マイクロサッカードは空間的な注意処理と社会的な認知処理を反映しており、ADHD傾向の診断において有用であると考えられた。

Publisher：Proceedings of the Design Society  

Resonance is known as an important phenomenon where individual creative moments resonate with each other during co-creation. The purpose of this study is to capture this co-creative moment as a resonant cognitive status with biosignal indicators. The authors conducted an experiment in which pairs of participants work on concept generation from two nouns and measured their dynamic creative status both subjectively and objectively with biosignal indicators fEMG and EOG. This study will help to understand co-creative cognitive phenomena and to improve the co-creative design process.

DOI： 10.1017/pds.2022.94

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Language：Japanese   Publisher：JAPAN SOCIETY FOR RESEARCH ON EMOTIONS  

DOI： 10.4092/jsre.30.supplement_os1-03

CiNii Research

Language：Japanese   Publisher：Japan Creativity Society  

It has been recognized that resonance, in which a shared mental image is formed and a creative psychological state resonates with others, is a qualitatively important phenomenon in creative collaboration. By using biosignal indicators to grasp resonance quantitatively, the authors ena-bled a methodological exploration of the interactions that foster the resonance. In this study, the authors attempted to capture creative psychological states with biosignal indicators by compar-ing multi-modal biosignal indicators such as electromyography (EMG) and electroretinography (EOG), measured during co-creative concept formation in pairs. The pair participants were asked to generate new concepts from two noun phrases, and to also report on how they per-ceived the creative psychological states and resonances experienced. As a result, differences between resonance and mere creative psychological states of two in a pair were captured by several biosignal indicators, such as the further activation of the orbicularis oculi muscle during resonance.

DOI： 10.24578/japancreativity.25.0_208

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Language：English   Publishing type：Research paper (scientific journal)  

The concept of alexithymia has garnered much attention in an attempt to understand the psychological mechanisms underlying the experience of feeling an emotion. In this study, we aimed to understand how the interoceptive processing in an emotional context relates to problems of alexithymia in recognizing self-emotions. Therefore, we prepared experimental conditions to induce emotional awareness based on interoceptive information. As such, we asked participants to be aware of interoception under an anxiety-generating situation anticipating pain, having them evaluate their subjective anxiety levels in this context. High alexithymia participants showed attenuated functional connectivity within their 'interoception network', particularly between the insula and the somatosensory areas when they focused on interoception. In contrast, they had enhanced functional connectivity between these regions when they focused on their anxiety about pain. Although access to somatic information is supposed to be more strongly activated while attending to interoception in the context of primary sensory processing, high alexithymia individuals were biased as this process was activated when they felt emotions, suggesting they recognize primitive and unprocessed bodily sensations as emotions. The paradoxical somatic information processing may reflect their brain function pathology for feeling emotions and their difficulty with context-dependent emotional control.

DOI： 10.1111/ejn.15528

Language：Others   Publishing type：Research paper (scientific journal)  

DOI： 10.1111/opo.12809

Language：Others   Publishing type：Research paper (scientific journal)  

Purpose: The thalamus, the region that forms the attentional network and transmits external sensory signals to the entire brain, is important for sleepiness. Herein, we examined the relationship between activity in the thalamus-seed brain network and subjective sleepiness.
Materials and Methods: Fifteen healthy male participants underwent an experiment comprising a baseline evaluation and two successive interventions, a 9-day sleep extension followed by 1-night total sleep deprivation. Pre- and post-intervention tests included the Karolinska sleepiness scale and neuroimaging for arterial spin labeling and functional connectivity. We examined the association between subjective sleepiness and the functional magnetic resonance imaging indices.
Results: The functional connectivity between the left or right thalamus and various brain regions displayed a significant negative association with subjective sleepiness, and the functional connectivity between the left and right thalamus displayed a significant positive association with subjective sleepiness. The graph theory analysis indicated that the number of positive functional connectivity related to the thalamus showed a strong negative association with subjective sleepiness, and conversely, the number of negative functional connectivity showed a positive association with subjective sleepiness. Arterial spin labeling analysis indicated that the blood flow in both the left and right thalami was significantly negatively associated with subjective sleepiness. Functional connectivity between the anterior cingulate cortex and salience network areas of the left insular cortex, and that between the anterior and posterior cingulate cortices showed a strong positive and negative association with subjective sleepiness, respectively.
Conclusion: Subjective sleepiness and the thalamic-cortical network dynamics are strongly related, indicating the application of graph theory to study sleepiness and consciousness. These results also demonstrate that resting functional connectivity largely reflects the “state” of the subject, suggesting that the control of sleep and conscious states is essential when using functional magnetic resonance imaging indices as biomarkers.

DOI： 10.2147/nss.s297309

Language：Japanese   Publishing type：Research paper (scientific journal)  

In modern society, many people have insomnia. Chronic insomnia has been noted as a risk factor for depression. However, there are few functional imaging studies of the brain on affective functions in chronic insomnia. This study aimed to investigate brain activities induced by emotional stimuli in chronic insomnia patients. Fifteen patients with primary insomnia and 30 age and gender matched healthy controls participated in this study. Both groups were presented images of fearful, happy, and neutral expressions consciously and non-consciously while undergoing MRI to compare the activity in regions of the brain responsible for emotions. Conscious presentation of the Happy-Neutral contrast showed significantly lower activation in the right orbitofrontal cortex of patients compared to healthy controls. The Happy-Neutral contrast presented in a non-conscious manner resulted in significantly lower activation of the ventral striatum, right insula, putamen, orbitofrontal cortex and ventral tegmental area in patients compared to healthy controls. Our findings revealed that responsiveness to positive emotional stimuli were decreased in insomniac patients. Specifically, brain networks associated with rewards and processing positive emotions showed decreased responsiveness to happy emotions especially for non-conscious image. The magnitude of activity in these areas also correlated with severity of insomnia, even after controlling for depression scale scores. These findings suggest that insomnia induces an affective functional disorder through an underlying mechanism of decreased sensitivity in the regions of the brain responsible for emotions and rewards to positive emotional stimuli.

Language：English   Publishing type：Research paper (scientific journal)  

Language：English   Publishing type：Research paper (scientific journal)   Publisher：Biological Rhythm Research  

In this study, we measured the physical quantity of light (irradiance) in several wavelength bands at eye and wrist level for 8 h under laboratory conditions simulating daily life. Twenty-two healthy male participants (mean age ± SD, 29.95 ± 8.13 years) were able to move freely, and eye-level data were compared with irradiance data obtained at the wrist. We estimated circadian phase shift from the differences of DLMO before and after light exposure while considering natural drift. In addition, we investigated the influence of activities and body positions on light exposure and validated the effect of irradiance on circadian phase response. We found lower average irradiance at eye level compared with wrist level in all three RGB bands. The blue light irradiance measured at eye level was significantly correlated with circadian phase shift, possibly because the irradiance at eye level more accurately reflected its effect on the biological clock than did the measurement at the wrist. It follows that quantitative measurements of wavelength spectra at eye level are necessary to assess the effect of ambient light on the human biological clock.

DOI： 10.1080/09291016.2020.1782691

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Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.1080/07420528.2020.1752704

Language：English   Publishing type：Research paper (scientific journal)  

Vigilance deficits account for a substantial number of accidents and errors. Current techniques to detect vigilance impairment measure only the most severe level evident in eyelid closure and falling asleep, which is often too late to avoid an accident or error. The present study sought to identify ocular biometrics of intermediate impairment of vigilance and develop a new technique that could detect a range of deficits in vigilant attention (VA). Sixteen healthy adults performed well-validated Psychomotor Vigilance Test (PVT) for tracking vigilance attention while undergoing simultaneous recording of eye metrics every 2 hours during 38 hours of continuous wakefulness. A novel marker was found that measured VA when the eyes were open-the prevalence of microsaccades. Notably, the prevalence of microsaccades decreased in response to sleep deprivation and time-on-task. In addition, a novel algorithm for detecting multilevel VA was developed, which estimated performance on the PVT by integrating the novel marker with other eye-related indices. The novel algorithm also tracked changes in intermediate level of VA (specific reaction times in the PVT, i.e. 300-500 ms) during prolonged time-on-task and sleep deprivation, which had not been tracked previously by conventional techniques. The implication of the findings is that this novel algorithm, named "eye-metrical estimation version of the PVT: PVT-E," can be used to reduce human-error-related accidents caused by vigilance impairment even when its level is intermediate.

DOI： 10.1093/sleep/zsz219

Language：English   Publishing type：Research paper (scientific journal)  

Cortisol is known to affect visuospatial memory through its major binding site in the brain, the hippocampus. The synchronization of neural activity between the hippocampus, prefrontal cortex (PFC), and visual cortex is presumed to be essential for the formation of visuospatial memory because of their visuospatial learning-dependent neuroplasticity. However, it remains unclear how hippocampal connectivity with the PFC and visual cortex is involved in the relationship between cortisol and visuospatial memory in humans. We thus investigated whether functional connectivity (FC) of the hippocampus, specifically its rostral and caudal subdivisions, mediates the relationship between visuospatial memory and endogenous cortisol. One-hundred sixty-six healthy young adults underwent standard neuropsychological tests to assess visuospatial construction (a complex figure copying test) and retrieval (the corresponding recall test) and collected their saliva at 6-time points across 2 consecutive days for measurement of daily cortisol concentrations (dCOR). Ninety of them received resting-state fMRI scans. Greater dCOR was significantly associated with better figure copying performance, but contrastingly with poorer figure recall. In proportion to dCOR, the rostral hippocampus (rHC) showed significantly increased FC with the PFC (including its dorsolateral and medial parts) and the inferior lateral occipital cortex (iLOC), while the caudal hippocampus had increased FC with the anterior middle temporal cortex. Of the cortisol-related hippocampal connectivity, the rHC-iLOC FC was specifically correlated with figure recall and showed complete mediation for the negative relationship of dCOR with figure recall. These results suggest that cortisol might have enhancing effects on visuospatial encoding as well as impairing effects on visuospatial retrieval, possibly due to its occupancy patterns of corticosteroid receptors. Cortisol's adverse effects on visuospatial retrieval might be explained through cortisol-related rostral hippocampal connectivity with the iLOC, which is a part of the extrastriate cortex implicated in visuospatial perception. Thorough dissection of hippocampal-prefrontal-extrastriate connectivity might facilitate the understanding of neural mechanisms underlying cortisol's contrasting effects on encoding (or consolidation) and retrieval of visuospatial information.

DOI： 10.1016/j.psyneuen.2019.04.013

Language：Japanese   Publishing type：Research paper (international conference proceedings)  

Language：English   Publishing type：Research paper (scientific journal)  

Background: Child maltreatment is a major health and social welfare problem, with serious and longstanding consequences. Impulse control ability plays an important role in reducing the risk of child maltreatment. The aim of this study was to investigate the associations of oxytocin (OXT) and prolactin (PRL) with behavior inhibition using children's facial expressions (angry or neutral) as emotional distractions. This may clarify a part of the neuroendocrinological mechanism that modulates impulse control ability in the context of child caregiving. Methods: Participants were 16 females who had never been pregnant. Following venous blood sampling for OXT and PRL levels, participants performed an emotional Go/Nogo task during their follicular and luteal phases to test inhibitory control ability. Behavioral performance and event-related potentials (ERPs) during the task were measured. Results: The results showed that there were significant fixed effects of OXT on behavioral performance, as measured by sensitivity (d-prime). This suggests that high peripheral OXT levels may be associated with better performance on the emotional Go/Nogo task, regardless of emotional distractors. PRL was associated with inhibitory processes as reflected by the Nogo-N2 and Nogo-P3. Particularly, high PRL levels were associated with the Nogo-N2 latency extension with the emotional distractors. Conclusions: Our findings suggest that OXT might be associated with improving behavioral performance regardless of emotional processes. It is suggested that processes related to PRL are related to premotor activities of behavioral inhibitions and emotions.

DOI： 10.1186/s40101-019-0196-z

Language：Japanese   Publishing type：Research paper (scientific journal)  

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DOI： 10.1016/j.jad.2018.06.018

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Language：English   Publishing type：Research paper (scientific journal)  

Epidemiological studies have shown that sleep debt increases the risk of obesity. Experimental total sleep deprivation (TSD) has been reported to activate the reward system in response to food stimuli, but food-related responses in everyday sleep habits, which could lead to obesity, have not been addressed. Here, we report that habitual sleep time at home among volunteers without any sleep concerns was shorter than their optimal sleep time estimated by the 9-day extended sleep intervention, which indicates that participants had already been in sleep debt in their usual sleep habits. The amygdala and anterior insula, which are responsible for both affective responses and reward prediction, were found to exhibit significantly lowered activity in the optimal sleep condition. Additionally, a subsequent one-night period of TSD reactivated the right anterior insula in response to food images; however, the activity level of amygdala remained lowered. These findings indicate that (1) our brain is at risk of hyperactivation to food triggers in everyday life, which could be a risk factor for obesity and lifestyle diseases, and (2) optimal sleep appears to reduce this hypersensitivity to food stimuli.

DOI： 10.1093/sleep/zsx137

Language：English   Publishing type：Research paper (scientific journal)  

Study objectives: Sleep debt (SD) has been suggested to evoke emotional instability by diminishing the suppression of the amygdala by the medial prefrontal cortex (MPFC). Here, we investigated how short-term SD affects resting-state functional connectivity between the amygdala and MPFC, self-reported mood, and sleep parameters.
Methods: Eighteen healthy adult men aged 29 +/- 8.24 years participated in a 2-day sleep control session (SC; time in bed [ TIB], 9 hours) and 2-day SD session (TIB, 3 hours). On day 2 of each session, resting-state functional magnetic resonance imaging was performed, followed immediately by measuring self-reported mood on the State-Trait Anxiety Inventory-State subscale (STAI-S).
Results: STAI-S score was significantly increased, and functional connectivity between the amygdala and MPFC was significantly decreased in SD compared with SC. Significant correlations were observed between reduced rapid eye movement (REM) sleep and reduced left amygdala-MPFC functional connectivity (FCL_amg-MPFC) and between reduced FCL_amg-MPFC and increased STAI-S score in SD compared with SC.
Conclusions: These findings suggest that reduced MPFC functional connectivity of amygdala activity is involved in mood deterioration under SD, and that REM sleep reduction is involved in functional changes in the corresponding brain regions. Having adequate REM sleep may be important for mental health maintenance.

DOI： 10.1093/sleep/zsx133

Language：English   Publishing type：Research paper (scientific journal)  

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Language：English   Publishing type：Research paper (scientific journal)  

We evaluated the circadian phenotypes of patients with delayed sleep-wake phase disorder (DSWPD) and non-24-hour sleep-wake rhythm disorder (N24SWD), two different circadian rhythm sleep disorders (CRSDs) by measuring clock gene expression rhythms in fibroblast cells derived from individual patients. Bmal1-luciferase (Bmal1-luc) expression rhythms were measured in the primary fibroblast cells derived from skin biopsy samples of patients with DSWPD and N24SWD, as well as control subjects. The period length of the Bmal1-luc rhythm (in vitro period) was distributed normally and was 22.80 +/- 0.47 (mean +/- s.d.) h in control-derived fibroblasts. The in vitro periods in DSWPD-derived fibroblasts and N24SWD-derived fibroblasts were 22.67 +/- 0.67 h and 23.18 +/- 0.70 h, respectively. The N24SWD group showed a significantly longer in vitro period than did the control or DSWPD group. Furthermore, in vitro period was associated with response to chronotherapy in the N24SWD group. Longer in vitro periods were observed in the non-responders (mean +/- s.d.: 23.59 +/- 0.89 h) compared with the responders (mean +/- s.d.: 22.97 +/- 0.47 h) in the N24SWD group. Our results indicate that prolonged circadian periods contribute to the onset and poor treatment outcome of N24SWD. In vitro rhythm assays could be useful for predicting circadian phenotypes and clinical prognosis in patients with CRSDs.

DOI： 10.1038/tp.2017.75

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DOI： 10.1371/journal.pone.0128005

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DOI： 10.1186/s40101-015-0053-7

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DOI： 10.1016/j.ijpsycho.2014.08.892

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DOI： 10.1186/1880-6805-33-31

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DOI： 10.1186/1471-2202-15-97

Language：Japanese   Publishing type：Research paper (scientific journal)  

In todays modern society, an increasing number of people have developed sleep-related problems, represented by sleep loss and chronic insomnia. These are due to drastic changes in living conditions such as prolonged work time, increased shift working, and various sociopsychological stresses. Sleep problems have been reported to strongly associate with emotional dysfunction in humans. Sleep loss cause not only daytime sleepiness and psychomotor impairment, but also emotional instability, anxiety and confusion, and chronic insomnia increases vulnerability to mood and anxiety disorders. Recent studies have revealed some of the neural basis of emotional regulation by sleep. For instance, continuous and accumulating sleep debt experienced in daily living could interfere with the functional regulation of the amygdala by ventral anterior cingulate cortex. And consequently this can induce an overreaction of the amygdala to negative emotional stimuli. Sleep-related mood disturbances may, in part, be attributable to the neural basis of emotional instability during sleep debt. In this text, recent findings on the functional linkage between sleep and emotional regulation have been reviewed.

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ASSOCIATION BETWEEN EMOTIONAL AWARENESS AND NEURAL CORRELATES OF INTEROCEPTION

Language：Others  

THE ASSOCIATION BETWEEN NEURAL RESPONSE AND HEART RATE VARIABILITY DURING ATTENDING TO BODILY SENSATIONS

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SLEEPINESS BY SLEEP DEBT ENHANCED AMYGDALA ACTIVATION FOR SUBLIMINAL SIGNALS OF FEAR

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WHY SLEEP DEPRIVATION RISK US OBESITY? AN FMRI STUDY

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THE NEURAL SUBSTRATES OF THE EMOTIONAL AUTOBIOGRAPHICAL MEMORY RETRIEVAL AND ITS RELATION TO ADAPTIVE COPING

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DOI： 10.1371/journal.pone.0056578

Language：English   Publishing type：Research paper (scientific journal)  

Objectives: Sleep debt reportedly increases emotional instability, such as anxiety and confusion, in addition to sleepiness and psychomotor impairment. However, the neural basis of emotional instability due to sleep debt has yet to be elucidated. This study investigated changes in emotional responses that are elicited by the simulation of short-term sleep loss and the brain regions responsible for these changes.
Subjects and Methods: Fourteen healthy adult men aged 24.1 +/- 3.3 years (range, 20-32 years) participated in a within-subject crossover study consisting of 5-day sessions of both sleep debt (4 h for time in bed) and sleep control (8 h for time in bed). On the last day of each session, participants underwent polysomnography and completed the State-Trait Anxiety Inventory and Profile of Mood States questionnaires. In addition, functional magnetic resonance imaging was conducted while performing an emotional face viewing task.
Results: Restricted sleep over the 5-day period increased the activity of the left amygdala in response to the facial expression of fear, whereas a happy facial expression did not change the activity. Restricted sleep also resulted in a significant decrease in the functional connectivity between the amygdala and the ventral anterior cingulate cortex (vACC) in proportion to the degree of sleep debt (as indicated by the percentage of slow wave sleep and delta wave power). This decrease was significantly correlated with activation of the left amygdala and deterioration of subjective mood state.
Conclusion: The results of this study suggest that continuous and accumulating sleep debt that can be experienced in everyday life can downregulate the functional suppression of the amygdala by the vACC and consequently enhance the response of the amygdala to negative emotional stimuli. Such functional alteration in emotional control may, in part, be attributed to the neural basis of emotional instability during sleep debt.

DOI： 10.1371/journal.pone.0056578

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Country：Japan  

Event date： 2020.6

Language：Japanese  

Country：Japan  

Event date： 2020.6

Language：English  

Country：Japan  

Event date： 2020.2

Language：English  

Venue：Modena   Country：Italy  

Managing negative emotions and promptly relieving anxiety are two main focuses in the prevention of mental illness. This paper indicates a biofeedback-training experience that helps an experiencer to manage his/her emotions. The authors have defined the following major problems to approach this bio-feedback design procedure. The first one is how to grasp human emotions using existing technologies in exhibition circumstances. The second one is what kind of manifestation should be used to create emotional resonance. For the first problem, Heart Rate Variability (HRV) is adopted to obtain anxiety and stress levels. For the second problem, the authors took a nature-inspired design approach. The results are visualized on a wall composed of 64 bionic scales. A device system guides the experiencer into a meditative state, and contributes to spurring thoughts on emotional management, and thus achieving the purpose of preventing mental illness.

Event date： 2019.6

Language：Japanese   Presentation type：Symposium, workshop panel (public)  

Country：Japan  

Event date： 2019.6

Language：Japanese   Presentation type：Oral presentation (general)  

Country：Japan  

Event date： 2019.3 - 2019.6

Language：English   Presentation type：Oral presentation (general)  

Country：Japan  

Event date： 2018.12

Language：Japanese   Presentation type：Oral presentation (general)  

Country：Japan  

Event date： 2018.10

Language：Japanese   Presentation type：Oral presentation (general)  

Country：Japan  

Event date： 2018.10

Language：Japanese   Presentation type：Oral presentation (general)  

Country：Japan  

Event date： 2018.7

Language：English   Presentation type：Oral presentation (general)  

Country：Japan  

Event date： 2018.6

Language：Japanese   Presentation type：Oral presentation (general)  

Country：Japan  

Event date： 2018.6

Language：Japanese  

Country：Japan  

Event date： 2018.5

Language：Japanese   Presentation type：Oral presentation (general)  

Country：Japan  

Event date： 2018.5

Language：Japanese   Presentation type：Oral presentation (general)  

Country：Japan  

Language：Japanese  

Country：Japan  

Language：Japanese  

Country：Japan  

Language：Others  

Country：Malaysia  

Language：Others  

Country：Malaysia  

Language：Japanese  

Country：Japan  

Language：Japanese  

Country：Japan  

Language：Japanese  

Country：Japan  

Language：Japanese  

Country：Japan  

Language：Japanese   Presentation type：Symposium, workshop panel (public)  

Country：Japan  

Language：Japanese  

Language：Japanese  

Language：Japanese  

Language：Japanese  

Language：Japanese  

Language：Japanese  

Language：Japanese  

Language：Japanese  

Language：Japanese  

Language：Japanese   Publisher：日本視覚学会  

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Language：Japanese   Publisher：日本生理心理学会  

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Language：Japanese   Publisher：日本生理心理学会  

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Language：Japanese   Publisher：(一社)日本睡眠学会  

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Language：Japanese   Publisher：日本感情心理学会  

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J-GLOBAL

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Language：Japanese  

Language：Japanese  

Language：Japanese  

Language：Japanese  

Language：Japanese  

Language：Japanese  

潜在的睡眠不足からの回復は前頭前野による扁桃体賦活抑制機能の改善を介して気分を改善する ASL-fMRI研究

Language：Japanese  

Language：Japanese  

Language：Japanese  

Language：Japanese   Publishing type：Article, review, commentary, editorial, etc. (scientific journal)  

Language：Japanese  

Language：Japanese  

・近年になり、日常生活で蓄積した睡眠負債の悪影響が注目され始めている。睡眠負債は眠気や精神運動機能の低下を引き起こし、情動調節機能の障害とも強い関連性をもつことが多く報告されている。・最近の研究において、睡眠負債がいかにして認知機能や情動に影響するか、その神経科学的メカニズムが部分的にではあるが明らかになってきている。例えば、認知機能の低下には睡眠促進物質の蓄積や全般的な注意機能を司る脳領域の機能低下がその背景にあることや、睡眠不足時には前頭領域による扁桃体の抑制機能の低下が気分の不安定性を引き起こすことが明らかにされている。・本稿では、筆者らの研究成果を交えながら、睡眠負債による認知機能・情動調節機能低下の脳内メカニズムに迫る近年の研究について概説する。(著者抄録)

Language：Japanese  

Language：Japanese  

Language：Japanese  

視床を中心とする脳内ネットワークと主観的眠気の関連 安静時fMRIによる検討

Language：Japanese  

慢性不眠症患者の情動機能 fMRI研究

Language：Japanese  

概日リズムへ影響する日常生活光の特性

Language：Japanese  

Language：Japanese  

新型分光放射照度センサーを使用した身体装着部位と光曝露との関連

Language：Japanese  

睡眠負債時における顔表情認知と情動伝染

Language：Japanese  

睡眠負債が道徳的行動に及ぼす影響とその神経基盤

Language：Japanese  

眼球運動と眼瞼運動を用いた眠気による注意低下の状態推定法

Language：Japanese  

概日リズム睡眠障害の治療反応性と末梢時計リズム周期

Language：Japanese  

日常生活における睡眠負債が肥満に及ぼす神経学的検証

Language：Japanese  

睡眠負債時における安静時気分の低下とその神経基盤 fMRI研究

Language：Japanese  

睡眠負債時における安静時気分の低下とその神経基盤 fMRI研究

Language：Japanese  

睡眠相後退型、フリーラン型の末梢時計リズム周期

Language：Japanese  

睡眠相後退型、フリーラン型の末梢時計リズム周期

Language：Japanese  

日常生活における睡眠負債が肥満に及ぼす神経学的検証

Language：Japanese  

睡眠・概日リズム機構が気分調節に及ぼす影響とその神経基盤
近年、睡眠や概日リズム機構の障害が気分調節に影響を与えることが示されており、鬱病、不安障害の発症や日中の抑鬱のリスク要因としても注目されている。その背景には、生活要因や生体リズム異常に起因する「睡眠の不調の影響」と、「生体リズム異常そのものの影響」の二つの要因が重なっていると考えられる。睡眠不足や不眠が気分調節機能や精神疾患の発症に及ぼす影響とそのメカニズム、さらに概日リズム機構と気分調節の連関メカニズムに関して、現在までに得られている知見を概説した。

Language：Japanese  

正または負の事象への共感に相手との親密性が与える影響

Language：Japanese  

精神生理研究部 睡眠延長による必要睡眠量と潜在的睡眠負債の推定

Language：Japanese  

精神生理研究部 原発性不眠症患者における情動刺激観察時の脳活動

Language：Japanese  

精神生理研究部 睡眠延長による必要睡眠量と潜在的睡眠負債の推定

Language：Japanese  

原発性不眠症患者は報酬処理に関連する脳部位の活動低下を示す fMRI研究

Language：Japanese  

肥満に関連する睡眠および食習慣の検討

Language：Japanese  

どのような睡眠習慣と食習慣が肥満リスクを高めるか

Language：Japanese  

睡眠延長による潜在的睡眠負債からの回復が気分調節に与える影響

Language：Japanese  

宇宙飛行士のヴィジランス評価における新規指標の必要性

Language：Japanese  

睡眠習慣および食習慣と肥満との関連に関する検討

Language：Japanese  

睡眠延長による必要睡眠量と潜在的睡眠負債の推定

Language：Japanese  

概日リズム睡眠障害の発症機序 末梢時計機能の評価

Language：Japanese  

慢性不眠症患者の脳構造 Voxel-based Morphometryを用いた検討

Language：Japanese  

睡眠延長による潜在的睡眠負債からの回復が気分調節に与える影響

Language：Japanese  

【日常生活の脳科学】 睡眠と情動 情動調節における睡眠の役割
現代社会では,増え続ける長時間労働やシフトワーク,さまざまな社会心理的ストレスなどの生活状況のめまぐるしい変化によって睡眠不足や不眠などの睡眠問題が増加しており,多くの現代人がこの問題に悩まされている。睡眠問題は情動機能の障害と強い関連性を持つことを示唆する数多くの報告がある。睡眠不足は眠気や精神運動機能の低下だけではなく,不安や混乱などの情動的不安定性を増加させる。また,慢性不眠症は気分障害,不安障害の発症脆弱性を高める。最近の研究によって,不適切な睡眠習慣による情動調節の障害メカニズムが,部分的にではあるが解明されつつある。例えば,日常的に体験するレベルの睡眠不足の蓄積により腹側前帯状皮質による扁桃体活動の調節異常が生じ,ネガティブな情動刺激に対する扁桃体の過剰反応が生じることが明らかになった。このような睡眠障害に起因する情動反応の亢進は,睡眠不足時にみられる情動的不安定性とその神経基盤を一部共有している可能性がある。本稿では,睡眠と情動調節の機能的連関に関する近年の研究について概説する。(著者抄録)

Language：Japanese  

睡眠習慣と摂食行動および肥満との関連

Language：Japanese  

若年者の睡眠習慣と肥満リスクに関する基礎的研究

Language：Japanese  

リアルタイムfMRIを用いたストレス関連疾患の治療法の開発

Language：Japanese  

新しい活動量計における睡眠/覚醒判定アルゴリズムの検討

Language：Japanese  

無意識的な情動伝達経路の役割 強い眠気は意識下で呈示された恐怖表情刺激に対する情動関連脳領域の活動を増強する

Language：Japanese  

安静時脳活動の測定による原発性不眠症患者における神経科学的病態の検討

Language：Japanese  

無意識的な情動伝達経路の役割:強い眠気は意識下で呈示された恐怖表情刺激に対する情動関連脳領域の活動を増強する

Language：Japanese  

概日リズム睡眠障害患者の生物時計機能障害

Language：Japanese  

新しい活動量計を用いた睡眠/覚醒判定アルゴリズムの作成

Language：English  

Language：Japanese  

睡眠負債は扁桃体 前頭前野間の機能的結合の減弱を介して、ネガティブな情動反応を惹起する

Language：Japanese  

睡眠負債は扁桃体‐前頭前野間の機能的結合の減弱を介して,ネガティブな情動反応を惹起する

Language：Japanese  

睡眠のマルチモダル画像研究 脳機能画像解析からみた睡眠負債時の情動・認知機能障害メカニズム

Language：Japanese  

短時間睡眠による睡眠負債が情動に関する脳機能に及ぼす影響

Language：Japanese  

部分断眠による睡眠負債が情動反応に与える影響 機能的MRIを用いた検討

Language：Japanese  

視覚が健常な概日リズム睡眠障害(自由継続型)患者は長い概日リズム周期を持つ

Language：Japanese  

部分断眠による睡眠負債が情動反応に与える影響:機能的MRIを用いた検討

Language：Japanese  

共感性の個人差と脳活動の関連性 事象関連電位を用いた検討

Type：Academic society, research group, etc. 

Type：Competition, symposium, etc. 

Type：Competition, symposium, etc. 

Type：Peer review 

Number of peer-reviewed articles in foreign language journals：2

Number of peer-reviewed articles in Japanese journals：2