九州大学 研究者情報
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河窪 正照(かわくぼ まさてる) データ更新日:2021.11.01



主な研究テーマ
医用画像解析
キーワード:医用画像、画像解析、心臓機能解析、血流解析、磁気共鳴画像診断
2011.04.
従事しているプロジェクト研究
戦略的創造研究推進事業(ACT-X) AI活用で挑む学問の革新と創成
2021.10~2024.03, 代表者:國吉 康夫, 東京大学 大学院情報理工学系研究科 教授, 科学技術振興機構(日本)
AI(人工知能)をはじめとする情報科学技術の急速な発展と普及により、様々な研究分野で新たな手法構築や格段の性能向上、対象範囲拡大等が進み、さらには革新的な課題設定や枠組み、新たな学問領域創成の可能性も見えつつあります。
このような、あらゆる学問の革新・創成の機会を活かし、進歩を先導し、将来のイノベーション創出につなげていくためには、各々の学問分野の極めて優秀で先進的な頭脳が柔軟な発想で、AI等の情報科学技術の活用やそれらとの学融合によって新たに拓ける世界を予見し、描き、開拓していくことが不可欠です。本研究領域では、理工系や人文社会系を含むあらゆる学問分野に最先端のAI等の情報科学技術を取り込むことで格段に強化・発展させることや、AI等の情報科学技術との融合による学問分野の革新や新たな学問領域の創成、新しい価値の創造などを目指す若手研究者による挑戦的な研究構想を求めます。
研究推進においては、人材育成の観点を重視し異分野の若手研究者同士が交流し相互に触発する場を設けることで、未来に貢献する先端研究を推進する研究人材の育成や、将来の連携につながる研究者の人的ネットワークの構築をはかります。
なお、本研究領域は文部科学省の人工知能/ビッグデータ/IoT/サイバーセキュリティ統合プロジェクト(AIPプロジェクト)を構成する「AIPネットワークラボ」の一環として運営していきます。.
研究業績
主要著書
1. 分担執筆:河窪 正照, 小林 幸次. 編集:杜下 淳次, 加藤 豊幸, 医用画像検査技術学 改訂4版, 株式会社南山堂, 5章 MR検査. p.263–p.346, 2020.11.
2. 「ポケット英和医学用語・略語辞典」編集委員会, ポケット英和医学用語・略語辞典, 南山堂, 第13版, 2011.01.
主要原著論文
1. Kawakubo M, Nagao M, Kikuchi N, Yamamoto A, Nakao R, Matsuo Y, Kaneko K, Watanabe E, Sasaki M, Nunoda S, Sakai S, 13N-ammonia positron emission tomography-derived left-ventricular strain in patients after heart transplantation validated using cardiovascular magnetic resonance feature tracking as reference, Ann Nucl Med. Epub ahead of print., 10.1007/s12149-021-01686-5, 2021.10,
Objective: Heart transplant rejection leads to cardiac allograft vasculopathy (CAV). 13N-ammonia positron emission tomography (PET) can be useful in detecting CAV, as it can evaluate both epicardial vessels and microvasculature. In this study, we evaluated the regional wall motion in heart transplant patients using our PET-specific feature-tracking (FT) algorithm for myocardial strain calculation and validated it using a cardiovascular magnetic resonance (CMR) FT strain as a reference.
Methods: A total of 15 heart transplant patients who underwent both 13N-ammonia PET and CMR within 3 months were retrospectively enrolled. The same slice position of short-axis cine images of the middle slice of left ventricle (LV) and the same slice position of horizontal long-axis cine images were selected for the two modalities to measure the circumferential strain (CS) and longitudinal strain (LS), respectively. Based on the FT technique, time-strain curves were calculated by semi-automatic tracking of the endocardial contour on cine images throughout a cardiac cycle. The peak value in the time-strain curve was defined as the representative value. Correlations of CS and LS between PET and CMR were analyzed using Pearson correlation coefficients. The inter-modality error of strain measurements was evaluated using intraclass correlation coefficients (ICCs) with two-way random single measures.
Results: Excellent correlations of CS and LS between PET and CMR were observed (CS: r = 0.80; p < 0.01; LS: r = 0.87; p < 0.01). Excellent ICCs were observed (0.89 and 0.85) in CS and LS derived from PET.
Conclusions: We propose the first PET strain showing an excellent agreement with the CMR strain and high reproducibility in measurement..
2. Kawakubo M*, Yamasaki Y, Toyomura D, Yamamura K, Sakamoto I, Moriyama T, Yabuuchi H, Ishigami K, *Corresponding author, Unchanged right ventricular strain in repaired tetralogy of Fallot after pulmonary valve replacement with radial long-axis cine magnetic resonance images, Scientific Reports, 10.1038/s41598-021-98464-0, 11, 1, 2021.09, [URL], We measured right ventricular (RV) strain by applying a novel postprocessing technique to conventional short-axis cine magnetic resonance imaging in the repaired tetralogy of Fallot (TOF) and investigated whether pulmonary valve replacement (PVR) changes the RV strain. Twenty-four patients with repaired TOF who underwent PVR and 16 healthy controls were enrolled. Global maximum and minimum principal strains (GPSmax, GPSmin) and global circumferential and longitudinal strains (GCS, GLS) were measured from short-axis cine images reconstructed radially along the long axis. Strain parameters before and after PVR were compared using paired t-tests. One-way ANOVA with Tukey post-hoc analysis was used for comparisons between the before and after PVR groups and the control group. There were no differences in strain parameters before and after PVR. The GPSmax before PVR was lower than that in the control group (P = 0.002). Before and after PVR, GCSs were higher and GLSs were lower than those in the control group (before and after GCSs: P = 0.002 for both, before and after GLSs: P < 0.0001 and P = 0.0003). RV strains from radially reconstructed short-axis cine images revealed unchanged myocardial motion after PVR. When compared to the control group, changes in GCS and GLS in TOF patients before and after PVR might be due to RV remodeling..
3. Arai H, Kawakubo M, Kadokami T, Editorial for: "Right/Left Ventricular Blood Pool T2 Ratio as an Innovative Cardiac MRI Screening Tool for the Identification of Left-to-Right Shunts in Patients with Right Ventricular Disease", J Magn Reson Imaging, doi: 10.1002/jmri.27880, 2021.08.
4. Masateru Kawakubo, Michinobu Nagao, Atsushi Yamamoto, Risako Nakao, Yuka Matsuo, Kenji Fukushima, Eri Watanabe, Akiko Sakai, Masayuki Sasaki, and Shuji Sakai, 13N-ammonia positron emission tomography-derived endocardial strain for the assessment of ischemia using feature-tracking in high-resolution cine imaging, Journal of Nuclear Cardiology. Epub ahead of print. Picked up in Editorial (https://link.springer.com/content/pdf/10.1007/s12350-021-02747-y.pdf)., 10.1007/s12350-021-02677-9, 2021.05, Background: Assessing endocardial strain using a single 13N-ammonia positron emission tomography (PET) scan would be clinically useful, given the association between ischemia and myocardial deformation. However, no software has been developed for strain analysis using PET. We evaluated the clinical potential of feature tracking-derived strain values measured using PET, based on associations
with the myocardial flow reserve (MFR).
Methods and Results: This retrospective study included 95 coronary artery disease patients who underwent myocardial 13N-ammonia PET. Semi-automatic measurements were made using a feature-tracking technique during myocardial cine imaging, and values were calculated using a 16-segment model. Adenosine-stressed global circumferential strain (CS) and global longitudinal strain (LS) values were compared with global MFR values. Stressed and resting global strain values were also compared. Global strain values were significantly lower in 39 patients with abnormal MFRs [<2.0] than in 56 patients with normal MFRs [≥2.0]. The global CS values in the stressed state were significantly decreased than the resting state values in patients with abnormal MFRs.
Conclusions: This study applied endocardial feature-tracking to 13N-ammonia PET, and the results suggested that blood flow and myocardial motility could be clinically assessed in ischemic patients using a single PET scan..
5. Kanatani R, Shirasaka T, Kojima T, Kato T, Kawakubo M*. *Corresponding author, Influence of beam hardening in dual- energy CT imaging: phantom study for iodine mapping, virtual monoenergetic imaging, and virtual non-contrast imaging, European Radiology Experimental, https://doi.org/10.1186/s41747-021-00217-1, 5, 18, 2021.04, [URL],
In this study, we investigated the influence of beam hardening on the dual-energy computed tomography (DECT) values of iodine maps, virtual monoenergetic (VME) images, and virtual non-contrast (VNC) images. 320-row DECT imaging was performed by changing the x-ray tube energy for the first and second rotations. DECT values of 5 mg/ mL iodine of the multi-energy CT phantom were compared with and without a 2-mm-thick attenuation rubber layer (~700 HU) wound around the phantom. It was found that the CT density values UH, with/without the rubber layer had statistical differences in the iodine map (184 ± 0.7 versus 186 ± 1.8), VME images (125 ± 0.3 versus 110 ± 0.4), and VNC images (−58 ± 0.7 versus −76 ± 1.7) (p < 0.010 for all). This suggests that iodine mapping may be underestimated by DECT and overestimated by VME imaging because of x-ray beam hardening. The use of VNC images instead of plain CT images requires further investigation because of underestimation..
6. Shiina Y, Kawakubo M, Inai K, Asagai S, Nagao M., Dual VENC 4D flow magnetic resonance imaging demonstrates arterial-pulmonary collaterals in an adult with tetralogy of Fallot, Eur Heart J Cardiovasc Imaging., 10.1093/ehjci/jeaa343., Online ahead of print., 2020.12.
7. T Kojima, M Nagao, H Yabuuchi, Y Yamasaki, T Shirasaka, M Kawakubo, K Fukushima, T Koto, A Yamamoto, R Nakao, A Sakai, E Watanabe, and S Sakai, New transluminal attenuation gradient derived from dynamic coronary CT angiography: diagnostic ability of ischemia detected by 13N-ammonia PET, Heart and Vessels, In Press, 2020.10.
8. Hideo Arai, Masateru Kawakubo*, Kenichi Sanui, Hiroshi Nishimura, Toshiaki Kadokami. *Corresponding author, Assessing myocardial circumferential strain using cardiovascular magnetic resonance after magnetic resonance-conditional cardiac resynchronization therapy, Radiology Case Reports, doi.org/10.1016/j.radcr.2020.07.063, 15, 10, 1954-1959, 2020.08, Nondrug therapy for arrhythmia patients had been developed dramatically until recent years. Cardiac resynchronization therapy (CRT), a nondrug therapy for arrhythmia, is especially utilized for the treatment of left ventricular (LV) severe heart failure caused by cardiac dyssynchrony. Prolonged QRS duration (≥130 ms) is strongly used as a CRT indication criterion, but QRS is not the direct clinical index of mechanical contraction delay of the LV myocardium. Therefore, identifying the presence of dyssynchrony by diagnostic imaging is necessary. Echocardiography is widely used for the assessment of dyssynchrony as a standard diagnostic imaging. Several studies have addressed the efficacy of cardiovascular magnetic resonance feature tracking (CMR-FT) in the diagnosis of dyssynchrony for arry- thmia patients. In addition, cardiac implantable electronic devices (CIEDs) were not avail- able to examine CMR until recent years; however, new MR-conditional CIEDs have become available for use before and after CRT. Recently, diagnostic imaging using CMR-FT has been attracting attention for the assessment of dyssynchrony. However, a strong metal artifact caused by CIEDs may make the analysis difficult after CRT implantation. Strain analysis us- ing short-axis (SA) cine CMR overcame this issue of artifact by enabling slice selection by avoiding artifact. Moreover, circumferential strain has superiority over other strain methods with respect to sensitivity, and we focused on these advantages. This case illustrates that circumferential strain with CMR-FT using SA cine CMR is useful in the assessment of improvement of myocardial motion after CRT and can provide useful additional information with imaging to determine the responders of CRT..
9. Yamasaki Y, Abe K, Kamitani T, Hosokawa K, Kawakubo M, Sagiyama K, Hida T, Matsuura Y, Murayama Y, Funatsu R, Tsutsui H, Yabuuchi H., Balloon pulmonary angioplasty improves right atrial reservoir and conduit functions in chronic thromboembolic pulmonary hypertension., European Heart Journal Cardiovascular Imaging, 10.1093/ehjci/jeaa064, 2020.05,
AIMS:
Right atrial (RA) function largely contributes to the maintenance of right ventricular (RV) function. This study investigated the effect of balloon pulmonary angioplasty (BPA) on RA functions in patients with inoperable chronic thromboembolic pulmonary hypertension (CTEPH) using cardiac magnetic resonance imaging (CMRI).
METHODS AND RESULTS:
CMRI and RV catheterization were performed before BPA sessions and at the follow-up periods in 29 CTEPH patients. Reservoir [RA longitudinal strain (RA-LS)], passive conduit [RA early LS rate (LSR)], and active (RA late LSR) phases were assessed by using cine CMRI and a feature-tracking algorithm. The relationships between the changes in RA functions and in brain natriuretic peptide (BNP) were evaluated in both the dilated and non-dilated RA groups. RA-LS (32.4% vs. 42.7%), RA LSR (6.3% vs. 8.3%), and RA early LSR (-2.3% vs. -4.3%) were improved after BPA, whereas no significant change was seen in RA late LSR. The changes in RA peak LS and in RA early LSR were significantly correlated with the changes in BNP (ΔRA-LS: r = -0.63, ΔRA-early LSR: r = 0.65) and pulmonary vascular resistance (PVR) (ΔRA-LS: r = -0.69, ΔRA-early LSR: r = 0.66) in the nondilated RA group.
CONCLUSION:
The RA reservoir and passive conduit functions were impaired in inoperable CTEPH, whereas RA active function was preserved. BPA markedly reversed these impaired functions. The improvements in RA reservoir and conduit functions were significantly correlated with the changes in BNP levels and PVR in CTEPH patients with normal RA sizes..
10. Shiina Y, Taniguchi K, Nagao M, Takahashi T, Niwa K, Kawakubo M, and Inai K., The relationship between extracellular volume fraction in symptomatic adults with tetralogy of Fallot and adverse cardiac events., Journal of Cardiology, DOI: 10.1016/j.jjcc.2019.09.009., 75, 4, 424-431, 2020.04.
11. Arai H, Kawakubo M*, Abe K, Hatashima H, Sanui K, Nishimura H, and Kadokami T. *Corresponding author, Quantification of intramyocardial hemorrhage volume using magnetic resonance imaging with three-dimensional T1-weighted sequence in patients with ischemia-reperfusion injury—a semi-automated image processing technique, The International Journal of Cardiovascular Imaging, 10.1007/s10554-019-01697-4, 36, 1, 111-119, 2020.01.
12. M Kawakubo, M Nagao, U Ishizaki, Y Shina, K Inai, Y Yamasaki, M Yoneyama, S Sakai., Feature-Tracking MRI Fractal Analysis of Right Ventricular Remodeling in Adults with Congenitally Corrected Transposition of the Great Arteries, Radiology: Cardiothoracic Imaging, 10.1148/ryct.2019190026, 1, 4, 2019.10, PurposeTo assess a recently available technique for quantification of right ventricular (RV) trabeculae that is based on fractal analysis performed by using cardiac MRI feature tracking, in patients with congenitally corrected transposition of the great arteries (cc-TGA).Materials and MethodsA total of 19 patients (eight men, 11 women; mean age, 35 years ± 10 [standard deviation]) with consecutive cc-TGA who underwent cardiac MRI were enrolled in the study. For analysis, patients were divided into two groups: six patients (four men, two women; mean age, 34 years ± 14) with an end-systolic RV volume index higher than 72 mL/m2 (indicative of adverse RV remodeling) and 13 patients (four men, nine women; mean age, 36 years ± 9) in whom this index was lower than or equal to 72 mL/m2 (indicative of adapted RV). The following outcomes were quantified in the midsection of the RV: fractional fractal dimension (FD) and diastolic FD, circumferential strain, and radial strain. Receiver operating characteristic (ROC) analysis was performed to determine the cutoff FD values for the detection of adverse RV remodeling. Correlations among fractional FD, diastolic FD, circumferential strain, and radial strain were calculated by using Pearson correlation coefficient (r) analysis.ResultsThe following ROC values were identified for fractional and diastolic FD: cutoff, 0.09 and 1.39, respectively; area under the ROC curve, 0.95 and 0.68, respectively; sensitivity, 1.00 and 0.33, respectively; and specificity, 0.92 and 1.00, respectively. Fractional FD correlated with circumferential strain and radial strain (r = −0.70 and 0.69, respectively; P < .01), as did diastolic FD (r = 0.37 and −0.38, respectively; P < .05).ConclusionThe fractional FD derived from cardiac MRI feature-tracking analysis correlates with adverse RV remodeling, including a changed strain pattern and trabeculae, in patients with cc-TGA..
13. R Nakao, M Nagao, K Fukushima, A Sakai, E Watanabe, M Kawakubo, S Sakai, N Hagiwara., Prediction of Cardiac Resynchronization Therapy Response in Dilated Cardiomyopathy Using Vortex Flow Mapping on Cine Magnetic Resonance Imaging, Circulation Reports, 10.1253/circrep.CR-18-0024, 1, 8, 333-341, 2019.08.
14. Kawakubo M*, Yamasaki Y, Kamitani T, Sagiyama K, Matsuura Y, Hino T, Abe K, Hosokawa K, Yabuuchi H, and Honda H. *Corresponding author, Clinical usefulness of right ventricular 3D area strain in the assessment of treatment effects of balloon pulmonary angioplasty in chronic thromboembolic pulmonary hypertension: comparison with 2D feature-tracking MRI, European Radiology, https://doi.org/10.1007/s00330-019-6008-3, 29, 9, 4583-4592, 2019.09, OBJECTIVES:
To evaluate the usefulness of right ventricular (RV) area strain analysis via cardiac MRI (CMRI) as a tool for assessing the treatment effects of balloon pulmonary angioplasty (BPA) in inoperable chronic thromboembolic pulmonary hypertension (CTEPH), RV area strain was compared to two-dimensional (2D) strain with feature-tracking MRI (FTMRI) before and after BPA.
METHODS:
We retrospectively analyzed 21 CTEPH patients who underwent BPA. End-systolic global area strain (GAS), longitudinal strain (LS), circumferential strain (CS), and radial strain (RS) were measured before and after BPA. Changes in GAS and RV ejection fraction (RVEF) values after BPA were defined as ΔGAS and ΔRVEF. Receiver operating characteristic (ROC) analyses were performed to determine the optimal cutoff of the strain at after BPA for detection of improved patients with decreased mean pulmonary artery pressure (mPAP) less than 30 mmHg and increased RVEF more than 50%.
RESULTS:
ROC analysis revealed the optimal cutoffs of strains (GAS, LS, CS, and RS) for identifying improved patients with mPAP < 30 mmHg (cutoff (%) = - 41.2, - 13.8, - 16.7, and 14.4: area under the curve, 0.75, 0.56, 0.65, and 0.75) and patients with RVEF > 50% (cutoff (%) = - 37.2, - 29.5, - 2.9, and 14.4: area under the curve, 0.81, 0.60, 0.56, and 0.56).
CONCLUSIONS:
Area strain analysis via CMRI may be a more useful tool for assessing the treatment effects of BPA in patients with CTEPH than 2D strains with FTMRI..
15. Arai H, Kawakubo M, Sanui K, Nishimura H, Kadokami T., Accurate and robust systolic myocardial T1 mapping using saturation recovery with individualized delay time: Comparison with diastolic T1 mapping, Radiol Phys Technol., https://doi.org/10.1007/s12194-018-0478-x, 11, 4, 415-422, 2018.09.
16. Kawakubo M*, Arai H, Nagao M, Yamasaki Y, Sanui K, Nishimura H, Kadokami T. *Corresponding author, Global left ventricular area strain using standard two-dimensional cine MR imaging with inter-slice interpolation, Cardiovascular Imaging: Asia, https://doi.org/10.22468/cvia.2018.00108, 2, 4, 187-193, 2018.10.
17. Kojima T, Kawakubo M, Nishizaka MK, Rahmawati A, Ando S, Chishaki SA, Nakamura Y, Nagao M, Assessment by airway ellipticity on cine-MRI to differentiate severe obstructive sleep apnea., Clinical Respiratory Journal, 10.1111/crj.12598., 12, 3, 878-884, 2018.03.
18. Kawakubo M*, Akamine H, Yamasaki Y, Takemura A, Abe K, Hosokawa K, Morishita J, Nagao M. *Corresponding author, Three-dimensional phase contrast magnetic resonance imaging validated to assess pulmonary artery flow in patients with chronic thromboembolic pulmonary hypertension., Radiological Physics and Technologies, 2016.10.
19. Kawakubo M*, Nagao M, Kumazawa S, Yamasaki Y, Chishaki AS, Nakamura Y, Honda H, Morishita J. *Corresponding author, Evaluation of ventricular dysfunction using semi-automatic longitudinal strain analysis of four-chamber cine MR imaging., The International Journal of Cardiovascular Imaging., 32, 2, 283-9, 2016.02.
20. Kawakubo M*, Yamasaki Y, Sakamoto I, Yamamura K, Nagao M. *Corresponding author, Clinical Impact of Interventricular Dyssynchrony in Repaired Tetralogy of Fallot: Myocardial Strain Analysis Using Semi-automatic Tracking of Cine Magnetic Resonance Imaging., Journal of Adult Congenital Heart Disease, Vol. 4, No. 2, 69-73, 2015.12.
21. Kawakubo M*, Nagao M, Kumazawa S, Chishaki AS, Mukai Y, Nakamura Y, Honda H, Morishita J. *Corresponding author, Evaluation of cardiac dyssynchrony with longitudinal strain analysis in 4-chamber cine MR imaging., European Journal of Radiology, 82, 12, 2212-2216, 2013.12.
主要総説, 論評, 解説, 書評, 報告書等
1. 長尾 充展、高橋 辰徳、椎名 由美、山崎 誘三、河窪 正照, 先天性心疾患を有する小児・成人における心臓血管核磁気共鳴のためのガイドラインとプロトコール:先天性心疾患のSCMRエキスパートコンセンサス, 2018.12.
2. 河窪 正照, 領域別最新動向:CT & MRIの技術と臨床を中心に:循環器(心臓MRIを中心に), 月刊インナービジョン2017年2月号, 2017.02.
3. 河窪 正照, MRIの最新動向, 月刊インナービジョン2017年2月号, 2017.02.
主要学会発表等
1. 豊村 大亮, 長友 雄作, 河窪 正照, 山崎 誘三, 福岡 将治, 鵜池 清, 平田 悠一郎, 山村 健一郎, 坂本 一郎, 石神 康生, 大賀 正一, Cardiac Magnetic Resonance Feature Trackingによるファロー四徴症術後の右房機能評価, 第57回小児循環器学会総会・学術集会, 2021.07.
2. 河窪正照, 長尾充展, 山本篤志, 中尾梨沙子, 松尾有香, 福島賢慈, 渡邊絵里, 坂井晶子, 佐々木雅之, 坂井修二, 高解像13N-アンモニアPET画像のfeature-trackingによる右心室ストレインと心筋虚血との関連, 第31回日本心臓核医学会総会・学術大会, 2021.06.
3. Yurie Shiraia, Masateru Kawakubo, Michinobu Nagao, Atsushi Yamamota, Yuka Matsuo, Misturu Momose, Risako Nakao, Kenji Fukushima, Masayuki Sasaki, and Shuji Sakai, 13N-ammonia PET-derived myocardial strain: first challenge for patients with coronary artery disease (CyPos賞 Bronze Medal), 第80回日本医学放射線学会, 2021.04.
4. M Kawakubo, M Nagao, A Yamamoto, R Nakao, Y Matsuo, K Fukushima, E Watanabe, A Sakai, M Sasaki, and S Sakai., 13N-アンモニアPETストレイン解析による右室壁運動と心筋血流予備能の関連, 第85回日本循環器学会学術集会, 2021.03.
5. 河窪 正照, 肺高血圧症の右心室リモデリングに対する治療戦略決定のための全自動画像解析, 国立研究開発法人日本医療研究開発機構 革新的医療技術創出拠点 令和二年度成果報告会, 2021.03.
6. 河窪 正照, 肺高血圧症の右心室リモデリングに対する 治療戦略決定のための全自動画像解析, 第8回TR推進合同フォーラム・ライフサイエンス技術交流会, 2021.02.
7. M Kawakubo, M Nagao, A Yamamoto, R Nakao, Y Matsuo, K Fukushima, E Watanabe, A Sakai, M Sasaki, and S Sakai., Potential of Right Ventricular Strain Estimated by 13N-Ammonia PET for the Assessment of Ischemic Cardiomyopathy, The 106th Scientific Assembly & Annual Meeting of the RSNA, 2020.11.
8. M Kawakubo, M Nagao, A Yamamoto, R Nakao, Y Matsuo, K Fukushima, E Watanabe, A Sakai, M Sasaki, and S Sakai., Feature-Tracking of High-Resolution Cine Imaging Derived From 13N-Ammonia PET: Diagnostic Ability of Longitudinal Strain for Detection of Myocardial Ischemia, The 106th Scientific Assembly & Annual Meeting of the RSNA, 2020.11.
9. 白井友理恵, 河窪正照, 長尾充展, 山本篤志, 松尾有香, 安藤聖恵, 中尾梨沙子, 坂井晶子, 福島賢慈, 渡邊絵理, 百瀬満, 坂井修二., アンモニアPETによる心筋ストレイン:新たな冠動脈疾患の機能評価(受賞あり), 第23回心世代核医学研究会, 2020.11.
10. 長尾充展, 河窪正照, 山本篤志, 松尾有香, 安藤聖恵, 中尾梨沙子, 坂井晶子, 福島賢慈, 渡邊絵理, 百瀬満, 坂井修二., アンモニアPETによる心筋ストレイン:虚血壁運動異常の検出, 第60回日本核医学会学術総会, 2020.11, [URL].
11. Koji Sagiyama, Masateru Kawakubo, Ryohei Funatsu, Takeshi Kamitani, Yuzo Yamasaki, Tomoyuki Hida, Yuko Matsuura, Hidetake Yabuuchi, Kousei Ishigami , Optical flow analysis combined with rapid cine MRI using compressed sensing could detect regional differences of lung motion in different postures
圧縮センシング併用高速シネ MRIのオプティカルフロー解析による体位変換後の肺局所運動の変化の検出, 第48回 日本磁気共鳴医学会大会, 2020.09.
12. Koji Sagiyama, Masateru Kawakubo, Ryohei Funatsu, Takeshi Kamitani, Yuzo Yamasaki, Tomoyuki Hida, Yuko Matsuura, Yuriko Murayama, and Hidetake Yabuuchi, Detecting regional differences of lung motion by optical flow analysis combined with rapid cine MRI using compressed sensing, ISMRM & SMRT VIRTUAL CONFERENCE & EXHIBITION, 2020.08, The application of cine MRI to lung disease has been technically challenging. In this study, we exploited optical flow analysis combined with rapid acquisition of cine MRI using compressed sensing to detect differences in regional lung motion. The high spatial and temporal resolution and higher signal-to-noise ratio of cine MRI enabled optical flow analysis to visualize regional differences between five lung segments. It also differentiated between chest and diaphragm breathing patterns in volunteers. In the future, this non-invasive method could be applied to assess and follow lung diseases, such as interstitial pneumonia or chronic obstructive pulmonary disease..
13. M. Kawakubo, M. Nagao, K. Fukushima, E. Watanabe, A. Sakai, S. Suzaki, Y. Shimomiya, S. Sakai, CT instantaneous wave-free ratio (iFR) for detecting functional coronary stenosis using whole heart dynamic imaging with dose modulated scan, European Congress of Radiology, 2020.07, [URL].
14. M. Kawakubo, M. Nagao, R. Nakao, E. Watanabe, M. Yoneyama, N. Hagiwara, S. Sakai, Association between decelerated dark flow in steady-state free precession cine cardiac MR imaging and left ventricular myocardial functions, European Congress of Radiology, 2020.07, [URL].
15. Kawakubo M, Nagao M, Nakao R, Watanabe E, Yoneyama M, Sakai S., SSFPシネMRIにおける減速流と左室心筋ストレインおよび左室同期障害との関連, 第47回日本磁気共鳴医学会大会, 2019.09.
16. 河窪 正照, 最新の心臓MR画像解析, 第111回 MR研究会, 2019.08.
17. 河窪 正照、長尾 充展、石崎 海子、椎名 由美、稲井 慶、山崎 誘三、米山 正巳、坂井 修二, MR画像のフラクタル解析による成人修正大血管転位における右心室リモデリングの評価 , 第89回日本心臓血管放射線研究会, 2019.07, [URL].
18. 河窪正照, 磁気共鳴画像を用いた心筋虚血再灌流傷害の非侵襲的診断法の確立, 第83回日本循環器学会学術集会, 2019.03.
19. Tsukasa Kojima, Michinobu Nagao, Takashi Shirasaka, Masateru Kawakubo, Yamato Shimomiya, Yuzo Yamasaki, Toyoyuki Kato, Shuji Sakai., Hybrid analysis of transluminal attenuation gradient and dynamic 320-detector coronary CT angiography: detection of functional coronary stenosis, European Congress of Radiology, 2019.03.
20. H Arai, M Kawakubo, M Eguchi, K Sanui, H Nishimura, and T Kadokami., How to quantify the intramyocardial hemorrhage after reperfusion injury: comparison to various semi-automatically methods, The 104th Scientific Assembly & Annual Meeting of the RSNA, 2018.11.
21. Arai H, Kawakubo M, Sanui K, Nishimura H, Kadokami T., Superiority of systolic T1 mapping with saturation recovery for errors of image registration and identification of myocardium, The 104th Scientific Assembly & Annual Meeting of the RSNA, 2018.11.
22. 河窪正照, 心臓の医用動画像を用いた視覚的かつ定量的な3次元の同期障害解析技術, 九州大学 新技術説明会, 2018.11, [URL].
23. Kawakubo M, Fukushima K, Nakao R, Watanabe E, Shimomiya Y, Goto Y, Tadenuma H, Yoneyama M, Nagao M, Vortex flow in left ventricle interrupts efficient ejection: Demonstration by vortex flow map of cardiac cine magnetic resonance imaging, ISMRM 26th Annual Meeting & Exhibition, 2018.06.
24. 河窪 正照, 福島 賢慈, 中尾 梨沙子, 下宮 大和, 後藤 康裕, 蓼沼 仁, 米山 正巳, 長尾 充展, シネMRI Vortex Flow Mapを用いた左室内渦流の幾何学的特徴と効率的駆出の関連, 第82回日本循環器学会学術集会, 2018.03.
25. Kawakubo M, Fukushima K, Nakao R, Shimomiya Y, Goto Y, Tadenuma H, Yoneyama M, Morishita J, Nagao M, Geometrical Vortex Flow in Left Ventricle Associates with Efficient Ejection: Analysis of a Novel Vortex Flow Map of 2D Cine MRI, The 45th Annual Meeting of Japanese Society of Magnetic Resonance in Medicine, 2017.09.
26. Kawakubo M, Yamasaki Y, Akamine H, Nagao M, Three-dimensional Bi-ventricular Myocardial Feature Tracking for Congenital Heart Disease Using Standard Cardiac Cine MRI with Interpolation Technique Based on Moving Gradients, ISMRM 25th Annual Meeting & Exhibition, 2017.04.
27. 河窪 正照, 山崎 誘三, 杜下 淳次, 長尾 充展, 動き勾配のパスに基づくシネ MR画像の時間的および空間的な補間による4次元の心臓MRイメージング, 第73回日本放射線技術学会総会学術大会, 2017.04.
28. Kawakubo M, Yamasaki Y, Sakamoto I, Yamamura K, Nagao M, Biventricular Strain and Torsion in Adults with Corrected Transposition of the Great Arteries Analyzed by Feature Tracking Cine MRI, The 102nd Scientific Assembly & Annual Meeting of the RSNA, 2016.11.
29. 河窪 正照, 山崎 誘三, 杜下 淳次, 長尾 充展, Feature Tracking Cine MRIによる心室の捻れ運動の評価, 第44回日本磁気共鳴医学会大会, 2016.09.
30. Kawakubo M, Nagao M, Kumazawa S, Yonezawa M, Yamasaki Y, Honda H, Chishaki AS, Nakamura Y, Morishita J, Semi-automatic Cardiac Longitudinal Strain Analysis Using Four-chamber Cine MR Imaging: Correlation with Left Ventricular Dysfunction, The 100th Scientific Assembly & Annual Meeting of the RSNA, 2014.12.
31. Kawakubo M, Nagao M, Kumazawa S, Chishaki AS, Honda H, Morishita J, Evaluation of Cardiac Mechanical Dyssynchrony with Longitudinal Strain Analysis in 4-chamber Cine Magnetic Resonance Imaging, ISMRM 20th Annual Meeting & Exhibition, 2012.05.
32. Kawakubo M, Nagao M, Kumazawa S, Chishaki AS, Honda H, Morishita J, Evaluation of Cardiac Mechanical Dyssynchrony Using 4-chamber Cine Magnetic Resonance Imaging: Assessment of Chronic Heart Failure, European Congress of Radiology, 2012.03.
特許出願・取得
特許出願件数  3件
特許登録件数  1件
学会活動
所属学会名
American Society of Nuclear Cardiology (ASNC)
日本心臓核医学会
日本循環器学会
日本磁気共鳴医学会
日本成人先天性心疾患学会
日本放射線技術学会
公益社団法人 日本診療放射線技師会
学協会役員等への就任
2017.04, 日本放射線技術学会, 計測部会 診断領域線量計標準センター.
学会大会・会議・シンポジウム等における役割
2021.09.13~2021.09.13, Symposium on Intelligent Data Science for Radiological Imaging between UM and KU, Chair person.
2020.01.11~2020.01.11, 2019年度第1回新ニーズに対応する九州がんプロ養成プラン 先端医用量子線技術科学コース講演会, 座長(Chairmanship).
2017.01.21~2017.01.21, MR研究会, 座長(Chairmanship).
学術論文等の審査
年度 外国語雑誌査読論文数 日本語雑誌査読論文数 国際会議録査読論文数 国内会議録査読論文数 合計
2020年度      
2018年度      
2017年度
2016年度
2015年度
その他の研究活動
海外渡航状況, 海外での教育研究歴
Dongseo Universiy, Korea, 2019.03~2019.03.
受賞
第10回学会賞技術部門, 日本心臓核医学会, 2021.06.
2017年度ISMRM Travel Award, 日本磁気共鳴医学会, 2018.03.
最優秀賞, 第34回せとうち心臓CT・MR勉強会, 2016.03.
座長推薦優秀研究, 日本放射線技術学会, 2015.04.
座長推薦優秀研究, 日本放射線技術学会, 2012.04.
Cum Laude, European Society of Radiology, 2012.03.
研究資金
科学研究費補助金の採択状況(文部科学省、日本学術振興会)
2020年度~2022年度, 若手研究, 代表, シネMRIによる体循環右室リモデリング解析のCRT効果予測における有用性の確立.
2016年度~2019年度, 若手研究(B), 代表, 3次元の心臓ストレイン解析法の開発と修正大血管転位の予後予測への応用.
競争的資金(受託研究を含む)の採択状況
2021年度~2023年度, 戦略的創造研究推進事業 (文部科学省), 代表, 同一者の血流情報に基づく心筋の虚血診断補助システム.
共同研究、受託研究(競争的資金を除く)の受入状況
2020.04~2022.03, 代表, 肺高血圧症の右心室リモデリングに対する治療戦略決定のための全自動画像解析.
寄附金の受入状況
2020年度, コニカミノルタ株式会社, 低線量胸部動態X線画像を用いた呼吸器、循環器疾患の病態解明および臨床的意義の検討.
2019年度, 公益財団法人 栢森情報科学振興財団, 畳み込みニューラルネットワークによる心臓の磁気共鳴動画像の呼吸ぶれ補正法の開発.
2019年度, 公益社団法人 臨床研究奨励基金, コメディカル臨床研究助成.
2018年度, 一般社団法人 日本循環器学会, メディカルスタッフ研究助成/磁気共鳴画像を用いた心筋虚血再灌流傷害の非侵襲的診断法の確立.
2017年度, 一般社団法人 日本磁気共鳴医学会, 2017年度ISMRM Travel Award/Vortex Flow in Left Ventricle Interrupts Efficient Ejection: Demonstration by Vortex Flow Map of Cardiac Cine Magnetic Resonance Imaging.
学内資金・基金等への採択状況
2019年度~2019年度, 外国語校閲経費支援, 代表, Influence of beam-hardening in dual-energy CT imaging: A phantom study for iodine map, virtual monoenergetic images, and virtual non-contrast images.
2018年度~2018年度, 数理・データサイエンスに関する教育・研究支援プログラム, 代表, Deep learningによる画像認識を応用した成人先天性心疾患の重症度自動診断システムの構築.
2018年度~2018年度, 外国語校閲経費支援, 代表, Right ventricular area strain measured with routine cine MRI after balloon pulmonary angioplasty in chronic thromboembolic pulmonary hypertension: Comparison with 2-dimensional feature-tracking MRI.

九大関連コンテンツ

pure2017年10月2日から、「九州大学研究者情報」を補完するデータベースとして、Elsevier社の「Pure」による研究業績の公開を開始しました。
 
 
九州大学知的財産本部「九州大学Seeds集」