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Masatake Tanaka Last modified date：2021.11.18

Assistant Professor / Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University
Department of Hepatology and Pancreatology
Kyushu University Hospital




Homepage
https://kyushu-u.pure.elsevier.com/en/persons/masatake-tanaka
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https://www.intmed3.med.kyushu-u.ac.jp/
The website of Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University .
Academic Degree
M.D., Ph.D.
Country of degree conferring institution (Overseas)
Yes　Doctor
Field of Specialization
Digestive Diseases and Liver Diseases
Total Priod of education and research career in the foreign country
03years06months
Research
Research Interests
  • The study for elucidating the mechanism of fibrosis in the NASH liver
    keyword : non-alcoholic steatohepatitis, NASH, fibrosis
    2018.10.
  • Analysis of the functions of the vascular and lymphatic vascular systems as the pathogeneses of various liver diseases
    keyword : Liver diseases, Liver fibrosis, Cirrhosis, Vascular system, Lymphatic vascular system, Microcirculation, Non-alcoholic steatohepatitis, NASH
    2018.10.
Academic Activities
Reports
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1. Masatake Tanaka, Yasuko Iwakiri, The Hepatic Lymphatic Vascular System
Structure, Function, Markers, and Lymphangiogenesis, CMGH, 10.1016/j.jcmgh.2016.09.002, 2016.11, The lymphatic vascular system has been minimally explored in the liver despite its essential functions including maintenance of tissue fluid homeostasis. The discovery of specific markers for lymphatic endothelial cells has advanced the study of lymphatics by methods including imaging, cell isolation, and transgenic animal models and has resulted in rapid progress in lymphatic vascular research during the last decade. These studies have yielded concrete evidence that lymphatic vessel dysfunction plays an important role in the pathogenesis of many diseases. This article reviews the current knowledge of the structure, function, and markers of the hepatic lymphatic vascular system as well as factors associated with hepatic lymphangiogenesis and compares liver lymphatics with those in other tissues..
2. Masatake Tanaka, Yasuko Iwakiri, Lymphatics in the liver, Current Opinion in Immunology, 10.1016/j.coi.2018.04.028, 2018.08, The liver is the largest lymph producing organ. A significant increase in the number of hepatic lymphatic vessels, or lymphangiogenesis, has been reported in various liver diseases, including, but not limited to, cirrhosis, viral hepatitis and hepatocellular carcinoma. Despite its apparent relevance in healthy and diseased livers as these and other observations indicate, the hepatic lymphatic system has been poorly studied. With knowledge of the lymphatic system in other organs and tissues incorporated, this review article addresses the current knowledge of the hepatic lymphatic system and the potential role of lymphatic endothelial cells in the health and the disease of the liver and concludes with a brief description on future directions of the study of the hepatic lymphatic system..
Papers
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Presentations
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Membership in Academic Society
  • American Association for the Study of Liver Diseases
  • THE JAPANESE SOCIETY OF INTERNAL MEDICINE
  • JAPANESE SOCIETY OF GASTROENTEROLOGY
  • JAPANESE SOCIETY OF MEDICAL ONCOLOGY
  • THE JAPAN SOCIETY OF HEPATOLOGY
  • American Association for the Study of Liver Diseases (AASLD)
Awards
  • Doctor of Distinct
  • Postdoctoral Research Fellowship
  • Pilot Feasibility Grant


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