Kyushu University Academic Staff Educational and Research Activities Database
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Daisuke Inoue Last modified date:2021.10.28

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Cytoskeletal Architecture and Bio-Self-Assembly lab official website. .
Academic Degree
Country of degree conferring institution (Overseas)
Field of Specialization
Biophysics, Micro/Nanotechnology, Material Science, BioArt
ORCID(Open Researcher and Contributor ID)
Total Priod of education and research career in the foreign country
Outline Activities
Self-organization is a process in which local interaction between components of a system spontaneously produces ordered structures, fascinating patterns which exhibit emergent functions in the absence of a professional designer. This is a common assembly process in biosystem and based on different construction principles and logics of design from that by human. Since self-organization grants several advantages to the system including robustness, flexibility and adaptability to the surrounding environment, application of inspiration of self-organization into human design is a great innovation.

To study self-organization in biosystem, a system comprising of cytoskeletons (microtubules and actin) and related motor proteins are one of the best candidates since they autonomously form various structures in eukaryotic cells and determines the morphology and function of cells. We are studying it using the reconstituted system of cytoskeleton combining with micro/nanotechnologies.

To explore potential applications of self-organization, our other challenge is to develop artificial systems organized through self-organization at human scales inspired by cytoskeletons.
Research Interests
  • Nonequilibrium self-organization of cytoskeleton, Development of artificial self-organizing materials
    keyword : Cytoskeleton, Motor protein, Self-organization, Active matter, Collective motion, DNA origami, Microfabrication
Academic Activities
1. Hamant Olivier, @Inoue Daisuke, Bouchez David, Dumais Jacques, Mjolsness Eric, Are microtubules tension sensors?, Nature Communications, 10.1038/s41467-019-10207-y, 2019.05.
2. 井上大介、Arif Md. Rashedul Kabir、角五彰、Gong Jian Ping, Soft actuators: Materials, modeling, applications, and future perspectives, Chapter 36. ATP-Driven Bio-Machine, Springer, 0.1007/978-4-431-54767-9_34, 2014.11, [URL].
1. Farhana Afroze, Daisuke Inoue, Tamanna Farhana, Tetsuya Hiraiwa, Ryo Akiyama, Arif MD. Rashedul Kabir, Kazuki Sada, Akira Kakugo, Monopolar flocking of microtubules in collective motion, Biochemical and Biophysical Research Communications, 2021.05.
2. Sarah Triclin, Daisuke Inoue, Jérémie Gaillard, Zaw Min Htet, Morgan E. DeSantis, Didier Portran, Emmanuel Derivery, Charlotte Aumeier, Laura Schaedel, Karin John, Christophe Leterrier, Samara L. Reck-Peterson, Laurent Blanchoin, Manuel Théry, Self-repair protects microtubules from destruction by molecular motors, Nature Materials,, 2021.01, [URL].
3. Inoue, Daisuke; Kabir, Arif Md. Rashedul; Tokuraku, Kiyotaka; Sada, Kazuki, Kakugo, Akira, Mechanical Stimulation-Induced Orientation of Gliding Microtubules in Confined Microwells, Advanced Materials Interfaces, 10.1002/admi.201902013, 2020.04.
4. Inoue, Daisuke; Gutmann, Greg; Nitta, Takahiro; Kabir, Arif Md Rashedul; Konagaya, Akihiko; Tokuraku, Kiyotaka; Sada, Kazuki; Hess, Henry; Kakugo, Akira, Adaptation of Patterns of Motile Filaments under Dynamic Boundary Conditions, ACS nano, 10.1021/acsnano.9b01450, 2019.10.
5. Inoue, Daisuke; Obino, Dorian; Pineau, Judith; Farina, Francesca; Gaillard, Jérémie; Guerin, Christophe; Blanchoin, Laurent; Lennon‐Duménil, Ana‐Maria; Théry, Manuel, Actin Filaments Regulate Microtubule Growth at the Centrosome, The EMBO journal, 10.15252/embj.201899630, 38, 11, e99630, 2019.03.
6. Triclin, Sarah*; Inoue, Daisuke*1(*第1著者と等貢献度); Gaillard, Jeremie; Htet, Zaw Min; De Santis, Morgan; Portran, Didier; Derivery, Emmanuel; Aumeier, Charlotte; Schaedel, Laura; John, Karin; Christophe, Leterrier; Samara, Reck-Peterson; Laurent, Blanchoin; Manuel, Thery, Self-Repair Protects Microtubules from their Destruction by Molecular Motors, bioRxiv, 10.1101/499020, 499020, 2018.12.
7. Sasaki, Ren; Kabir, Arif Md Rashedul; Inoue, Daisuke; Anan, Shizuka; Kimura, Atsushi P; Konagaya, Akihiko; Sada, Kazuki; Kakugo, Akira, Construction of Artificial Cilia from Microtubules and Kinesins through a Well-Designed Bottom-up Approach, Nanoscale, 10.1039/C7NR05099B, 10, 14, 6323-6332, 2018.02.
8. Keya, Jakia Jannat*; Inoue, Daisuke*(*第1著者と等貢献度); Suzuki, Yuki; Kozai, Toshiya; Ishikuro, Daiki; Kodera, Noriyuki; Uchihashi, Takayuki; Kabir, Arif Md Rashedul; Endo, Masayuki; Sada, Kazuki, High-Resolution Imaging of a Single Gliding Protofilament of Tubulins by HS-AFM, Scientific reports, 10.1038/s41598-017-06249-1, 7, 1, 6166, 2017.07.
9. Inoue, Daisuke; Nitta, Takahiro; Kabir, Arif Md Rashedul; Sada, Kazuki; Gong, Jian Ping; Konagaya, Akihiko; Kakugo, Akira;, Sensing Surface Mechanical Deformation Using Active Probes Driven by Motor Proteins, Nature communications, 10.1038/ncomms12557, 7, 12557, 2016.07.
10. Inoue, Daisuke; Mahmot, Bulbul; Kabir, Arif Md Rashedul; Farhana, Tamanna Ishrat; Tokuraku, Kiyotaka; Sada, Kazuki; Konagaya, Akihiko; Kakugo, Akira, Depletion Force Induced Collective Motion of Microtubules Driven by Kinesin, Nanoscale, 10.1039/C5NR02213D, 7, 43, 18054-18061, 2015.07.
11. Inoue, Daisuke; Kabir, Arif Md Rashedul; Mayama, Hiroyuki; Gong, Jian Ping; Sada, Kazuki; Kakugo, Akira, Growth of Ring-Shaped Microtubule Assemblies through Stepwise Active Self-Organisation, Soft Matter, 10.1039/C3SM50704A, 9, 29, 7061-7068, 2013.05.
12. Kabir, Arif Md Rashedul; Wada, Shoki; Inoue, Daisuke; Tamura, Yoshiki; Kajihara, Tamaki; Mayama, Hiroyuki; Sada, Kazuki; Kakugo, Akira; Gong, Jian Ping, Formation of Ring-Shaped Assembly of Microtubules with a Narrow Size Distribution at an Air–Buffer Interface, Soft Matter, 10.1039/C2SM26441B, 8, 10863-10867, 2012.11.
Works, Software and Database
2. .
1. Daisuke Inoue, Fantastic Voyage in VRCell world , VIZBI - Visualizing Biological Data, 2021.03, [URL].
2. Daisuke Inoue, Designing artificial microtubule nucleus by DNA nanotube , ASCB Cell Bio Virtual 2020, 2020.05, [URL].
3. Daisuke Inoue, Artificial γ-TuRC made by DNA origami, 第58回日本生物物理学会年会, 2020.09.
4. Daisuke Inoue, Design of microtubule lattice structures using DNA origami seeds, EMBO/EMBL Symposium Microtubules from atoms to complex systems, 2020.06.
5. Daisuke Inoue, Franky Djutanta, Rizal F. Hariadi, Design of microtubule lattice structures using programmable DNA origami seeds, The 20th RIES-HOKUDAI International Symposium, 2019.12.
Membership in Academic Society
  • The American Society for Cell Biology
  • The Biophisical Societiy Of Japan