092-642-6882

092-642-6383

No

regulation of transcription dynamics

0000-0001-6672-4093

00years00months

The use of fluorescence imaging in multispatial omics technologies represents a groundbreaking approach that allows for the observation of the localization of DNA, RNA, and proteins at the single-cell level. Efforts are being made to enhance the detection sensitivity of molecular species, aiming for the development of more precise technologies. This advancement facilitates the analysis of intricate and large-scale intranuclear biological phenomena. Furthermore, by integrating high-precision visualization techniques for the simultaneous imaging of specific gene transcription and gene loci, progress is being made in elucidating the mechanisms of transcriptional regulation by higher-order genome structures.

Research Interests

• The goal is to elucidate the gene transcription regulation mechanisms mediated by genome imprinting. Genome imprinting is a phenomenon where differences in gene expression levels between alleles arise due to differences in the epigenomes of males and females, particularly in DNA methylation. This regulatory mechanism is modulated by multiple factors, including the higher-order genome structure within the nucleus, transcriptional repressors, and transcription co-factors. To uncover the details of this molecular mechanism, research is being conducted using specific areas of live-cell imaging and multispatial omics technologies. Since disruptions in genome imprinting can lead to hereditary diseases, understanding its intricate control mechanisms lays the foundation for elucidating the pathophysiology of human diseases and developing therapeutic strategies.
  keyword : Genomic imprinting
  2023.03.

Academic Activities