092-802-4598

Doctor of Agricultural Science

Yes　Bachelor　Master　Doctor

Chronobiology, animal physiology

0000-0001-5606-3965

00years00months

　　　　　Many organisms living on the Earth have a circadian clock with about 24-hour period, allowing important physiological functions to adapt to ambient light-dark cycle. A master clock in the brain called the suprachiasmatic nucleus (SCN) governs peripheral rhythms via hormonal and neural pathways. Furthermore, this clock is also important for seasonal responses by photoperiodic time measurement. Understanding these mechanisms will not only contribute animal reproduction and health, but also lead to breakthroughs in solving various issues facing modern society.
　　　Currently, we are using mice, cells, and BIG data to understand glaucoma, which has the highest rate of blindness by using medical, behavioral, molecular biological, histological, physiological, functional, and data science techniques. We aim to elucidate the molecular mechanism underlying diurnal rhythm of intraocular pressure (inner eye pressure), and the relationship with lifestyle.
　　　 In addition, melatonin in the pineal gland, known as a sleep hormone, is known to be important in the circadian regulation and seasonal responses. However, its effects on other physiological functions remains uncovered. Furthermore, although pineal humoral factors other than melatonin are also synthesized, their functions also remain unclear. Therefore, we are trying to elucidate the physiological regulation of the pineal gland on the circadian clock, behavior, mood, and perceptual functions.

Research Interests

• Understanding of molecular mechanisms on circadian intraocular pressure rhythm
  keyword : IOP, glaucoma, circadian rhythm, glucocorticoids, sympathetic noradrenaline, ciliary body, trabecular meshwork, aqueous humor
  2020.04.
• Mechanisms of Life style on glaucoma development
  keyword : life style, sleep, feeding, exacise, stress, IOP, glaucoma, season
  2023.01.
• Pathway research of time signals regulating circadian intraocular pressure rhythm.
  keyword : glucocorticoids, sympathetic nerve system, noradrenaline, SCG, adrenal gland, IOP, circadian rhythm, mice, Per2lucKI, cBmal1KO
  2018.04～2020.10.
• Effects of St8sia2 and its flanking region's IGF1 gene on murine development.
  keyword : St8sia2, sialic acid, IGF1, brain, lethal, embryo, development, flanking region, C57BL/6 mice
  2013.06～2019.06.
• Regulatory mechanisms of pineal gland on circadian physiological functions
  keyword : pineal gland, melatonin, circadian rhythm, suprachismatic nucleous, free-running period, jet-lag, negative-masking, retina, Opn4
  2016.09.
• Regulatory mechanisms of pineal humoral factors on mood in mice
  keyword : pineal gland, melatonin, mice, autism, ASD, hyper activity, spcial interaction, brain development
  2015.04.
• Circadian yawning rhythm in rat
  keyword : yawning, rat, diurnal changes, siesta
  2014.03.
• Molecular mechanisms of photoperiodic time-measurement in vertebrates
  keyword : photoperiodism, seasonal reproduction, circadian clock, day-length, TSH, mice, quail
  2008.04～2013.03.
• Glycans on TSH give dual physiological functions
  keyword : Thyroid stimulating hormone, spring hormone, pars tuberalis, thyroid gland, sialic acid, IgG albumine, season
  2010.04～2014.04.
• Exploring of seasonal calender in fish brain
  keyword : saccus vasculosus, pituitary gland, photoreceptor, TSH, Dio2, gonadal development
  2010.04～2012.12.
• Effects of insuin on hepatic circadian rhythm regulation.
  keyword : circadian clock genes, cell culture, phase, insulin, liver, rat
  2007.04～2008.03.

Academic Activities Membership in Academic Society

• JAPANESE SOCIETY OF DEVELOPMENTAL BIOLOGISTS
• PHYSIOLOGICAL SOCIETY OF JAPAN
• JAPANESE SOCIETY FOR CHRONOBIOLOGY
• Society for Research on Biological Rhythms
• European Biological Rhythms Society

Awards

• Young Investigator Award

Educational Activities