Kyushu University Academic Staff Educational and Research Activities Database
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Sachiko Kanaji Last modified date:2024.05.20

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 Reseacher Profiling Tool Kyushu University Pure
Academic Degree
 MD, PhD
Country of degree conferring institution (Overseas)
Field of Specialization
Thrombosis and Hemostasis, Laboratory Medicine
Total Priod of education and research career in the foreign country
Academic Activities
1. 10. Kanaji S, Chen W, Morodomi Y, Shapiro R, Kanaji T, Yang XL, Mechanistic perspectives on anti-aminoacyl-tRNA synthetase syndrome, Trends Biochem Sci, 10.1016/j.tibs.2022.09.011, 2023.03.
1. Kanaji T, Morodomi Y, Kanaji S, Circulating immune cells with megakaryocyte signature in response to COVID-19 mRNA vaccination, Thromb Res, 10.1016/j.thromres.2022.10.003, 220, 1, 2022.12.
2. Morodomi Y, Kanaji S, Sullivan BM, Zarpellon A, Orje JN, Won E, Shapiro R, Yang XL, Ruf W, Schimmel P, Ruggeri ZM, Kanaji T, Inflammatory platelet production stimulated by tyrosyl-tRNA synthetase mimicking viral
infection, Proc Natl Acad Sci U S A, 10.1073/pnas.2212659119, 119, 48, e2212659119, 2022.11.
3. Kanaji S, Morodomi Y, Weiler H, Zarpellon A, Montgomery RR, Ruggeri ZM, Kanaji T, The impact of aberrant von Willebrand factor-GPIbα interaction on megakaryopoiesis and platelets in humanized type 2B von Willebrand disease model mouse, Haematologica, 10.3324/haematol.2021.280561, 107, 9, 2133, 2022.09.
4. Nakamura T, Morodomi Y, Kanaji S, Okamura T, Nagafuji K, Kanaji T, Detection of anti-GPIbα autoantibodies in a case of immune thrombocytopenia following COVID-19 vaccination, Thromb Res, 10.1016/j.thromres.2021.11.030, 209, 80, 2022.01.
5. Morodomi Y, Kanaji S, Won E, Ruggeri ZM, Kanaji T, Mechanisms of anti-GPIbalpha antibody-induced thrombocytopenia in mice, Blood, 10.1182/blood.2019003770, 135, 25, 2292, 2020.06.
6. Kanaji S, Orje JN, Kanaji T, Kamikubo Y, Morodomi Y, Chen Y, Zarpellon A, Eberhardt J, Forli S, Fahs SA, Sood R, Haberichter SL, Montgomery RR, Ruggeri ZM, Humanized GPIbalpha-von Willebrand factor interaction in the mouse, Blood Adv, 10.1182/bloodadvances.2018023507, 2, 19, 2522, 2018.10.
7. Kanaji T, Vo MN, Kanaji S, Zarpellon A, Shapiro R, Morodomi Y, Yuzuriha A, Eto K, Belani R, Do MH, Yang XL, Ruggeri ZM, Schimmel P, Tyrosyl-tRNA synthetase stimulates thrombopoietin-independent hematopoiesis accelerating recovery from thrombocytopenia, Proc Natl Acad Sci U S A, 10.1073/pnas.1807000115, 115, 35, E8228, 2018.08.
8. Kanaji S, Fahs SA, Ware J, Montgomery RR, Shi Q, Non-myeloablative conditioning with busulfan before hematopoietic stem cell transplantation leads to phenotypic correction of murine Bernard- Soulier syndrome, J Thromb Haemost, 10.1111/jth.12673, 12, 10, 1726, 2014.10.
9. Kanaji T, Kanaji S, Montgomery RR, Patel SB, Newman PJ, Platelet hyperreactivity explains the bleeding abnormality and macrothrombocytopenia in a murine model of sitosterolemia, Blood, 10.1182/blood-2013-06-510461, 122, 15, 2732, 2013.10.
10. Kanaji S, Fahs SA, Shi Q, Haberichter SL, Montgomery RR, Contribution of platelet vs. endothelial VWF to platelet adhesion and hemostasis, J Thromb Haemost, 10.1111/j.1538-7836.2012.04797.x, 10, 8, 1646, 2012.08.
11. Kanaji S, Kuether EL, Fahs SA, Schroeder JA, Ware J, Montgomery RR, Shi Q, Correction of murine Bernard-Soulier syndrome by lentivirus-mediated gene therapy, Mol Ther, 10.1038/mt.2011.231, 20, 3, 625, 2012.03.
12. Kanaji S, Kanaji T, Honda M, Nakazato S, Wakayama K, Tabata Y, Shibata S, Gondo H, Nakamura I, Node K, Miura M, Miyahara M, Okamura T, Nagumo F, Ohta S, Izuhara K, Identification of four novel mutations in F5 associated with congenital factor V deficiency, Int J Hematol, 10.1007/s12185-008-0210-4, 89, 1, 71, 2009.01.
13. Kanaji S, Kanaji T, Migita M, Kunishima S, Kunicki TJ, Okamura T, Izuhara K, Characterization of a patient with atypical amegakaryocytic thrombocytopenia, Eur J Haematol, 10.1111/j.1600-0609.2008.01029.x, 80, 4, 361, 2008.04.
14. Kanaji S, Tanaka Y, Sakata Y, Takeshita K, Arima K, Ohta S, Hansell EJ, Caffrey C, Mottram JC, Lowther J, Donnelly S, Stack C, Kadowaki T, Yamamoto K, McKerrow JH, Dalton JP, Coombs GH, Izuhara K, Squamous cell carcinoma antigen 1 is an inhibitor of parasite-derived cysteine proteases, FEBS Lett, 10.1016/j.febslet.2007.07.072, 581, 22, 4260, 2007.09.
15. Kanaji S, Kanaji T, Jacquelin B, Chang M, Nugent DJ, Komatsu N, Moroi M, Izuhara K, Kunicki TJ, Thrombopoietin initiates demethylation-based transcription of GP6 during megakaryocyte differentiation, Blood, 10.1182/blood-2004-08-3109, 105, 10, 3888, 2005.05.
16. Kanaji S, Kanaji T, Furihata K, Kato K, Ware JL, Kunicki TJ, Convulxin binds to native, human glycoprotein Ib alpha, J Biol Chem, 10.1074/jbc.M300199200, 278, 41, 39452, 2003.10.
17. Kato K, Kanaji T, Russell S, Kunicki TJ, Furihata K, Kanaji S, Marchese P, Reininger A, Ruggeri ZM, Ware J, The contribution of glycoprotein VI to stable platelet adhesion and thrombus formation illustrated by targeted gene deletion, Blood, 10.1182/blood-2003-03-0717, 102, 5, 1701, 2003.09.
18. Kanaji T, Kanaji S, Osaki K, Kuroiwa M, Sakaguchi M, Mihara K, Niho Y, Okamura T, Identification and characterization of two novel mutations (Q421 K and R123P) in congenital factor XII deficiency, Thromb Haemost, 86, 6, 1409, 2001.12.
19. Kanaji S, Iwahashi J, Kida Y, Sakaguchi M, Mihara K, Characterization of the signal that directs Tom20 to the mitochondrial outer membrane, J Cell Biol, 10.1083/jcb.151.2.277, 151, 2, 277, 2000.10.
20. Kanaji S, Okuma K, Tokumitsu Y, Yoshizawa S, Nakamura M, Niho Y, Hemophagocytic syndrome associated with fulminant ulcerative colitis and presumed acute pancreatitis, Am J Gastroenterol, 0.1111/j.1572-0241.1998.00554.x, 93, 10, 1956, 1998.10.
Membership in Academic Society
  • American Society of Hematology
  • International Society on Thrombosis and Haemostasis