環境調和型新規触媒反応の開発
キーワード:有機合成化学、触媒化学、不斉合成、遷移金属
2010.07~2015.06.



森本 浩之(もりもと ひろゆき) | データ更新日:2022.06.17 |

主な研究テーマ
研究業績
主要著書
1. | 大嶋 孝志, 森本 浩之, 森崎一宏, Catalytic Asymmetric 1,2-Alkynylation, Elsevier, 10.1016/B978-0-12-409547-2.11504-5, Reference Module in Chemistry, Molecular Sciences and Chemical Engineering, 2015., 2015.02, [URL]. |
主要原著論文
1. | Tetsuya Kadota, Masanao Sawa, Yuta Kondo, Hiroyuki Morimoto, Takashi Ohshima, Catalytic Enantioselective Strecker Reaction of Isatin-Derived N-Unsubstituted Ketimines, Organic Letters, 10.1021/acs.orglett.1c01194, 2021.06, A catalytic enantioselective Strecker reaction of isatin-derived N-unsubstituted ketimines directly afforded the N-unprotected α-aminonitriles with a tetrasubstituted carbon stereocenter in up to 99% ee without requiring protection/deprotection steps. One-pot Strecker reactions from the parent carbonyl compounds were also realized with comparable yields and enantioselectivities. Direct transformations of the N-unprotected α-aminonitrile products streamlined the synthesis of unnatural amino acid derivatives and achieved the shortest one-pot stereoselective routes to a biologically active compound reported to date.. |
2. | Morisaki, Kazuhiro; Morimoto, Hiroyuki; Ohshima, Takashi, Recent Progress on Catalytic Addition Reactions to N-Unsubstituted Imines, ACS CATALYSIS, 10.1021/acscatal.0c01212, 10, 12, 6924-6951, 2020.06, Catalytic addition reactions to N-unsubstituted (N-unprotected) imines can provide a more straightforward synthesis of amines. This direct process eliminates the unnecessary protecting-group manipulations that are required with N-substituted (N-protected) imines and can contribute to the development of green chemistry. Although their use has been limited due to difficulties associated with the nature of N-unsubstituted imines, recently developed catalytic methods enable the use of N-unsubstituted imines as electrophiles in various catalytic addition reactions. To facilitate an understanding of the state of the art development of synthetic methodologies, herein we review recent progress on catalytic addition reactions to N-unsubstituted imines. We begin with an overview of the chemistry of N-unsubstituted imines, followed by a summary of recent progress categorized according to the reaction type. We hope this review will help to stimulate further development of greener syntheses of nitrogen-containing compounds.. |
3. | Yuta Kondo, Tetsuya Kadota, Yoshinobu Hirazawa, Kazuhiro Morisaki, Hiroyuki Morimoto, Takashi Ohshima, Scandium(III) Triflate Catalyzed Direct Synthesis of N-Unprotected Ketimines, Organic Letters, 10.1021/acs.orglett.9b04038, 22, 1, 120-125, 2020.01, [URL], N-Unprotected ketimines are useful substrates and intermediates for synthesizing valuable nitrogen-containing compounds, but their potential applicability is limited by the available synthetic methods. To address this issue, we report a scandium(III) triflate catalyzed direct synthesis of N-unprotected ketimines. Using commercially available reagents and Lewis acid catalysts, ketones were directly transformed into the corresponding N-unprotected ketimines in high yields with broad functional group tolerance, even in multigram scales. The reactions were readily applicable for one-pot synthesis of important compounds such as a glycine Schiff base without isolation of N-unprotected ketimine intermediates. Preliminary mechanistic studies to clarify the reaction mechanism are also described.. |
4. | Masanao Sawa, Shotaro Miyazaki, Ryohei Yonesaki, Hiroyuki Morimoto, Takashi Ohshima, Catalytic Enantioselective Decarboxylative Mannich-Type Reaction of N-Unprotected Isatin-Derived Ketimines, Organic Letters, 10.1021/acs.orglett.8b02306, 20, 17, 5393-5397, 2018.09, [URL], The first catalytic enantioselective decarboxylative Mannich-type reaction of N-unprotected ketimines is reported, directly providing N-unprotected 3-tetrasubstituted 3-aminooxindoles in high yield and ee without protection/deprotection steps. The utility of this reaction is demonstrated in the short step synthesis of (+)-AG-041R.. |
5. | Toru Deguchi, Hai Long Xin, Hiroyuki Morimoto, Takashi Ohshima, Direct Catalytic Alcoholysis of Unactivated 8-Aminoquinoline Amides, ACS Catalysis, 10.1021/acscatal.7b00442, 7, 5, 3157-3161, 2017.05, [URL], Direct catalytic alcoholysis of unactivated amides is one of the most difficult challenges in organic chemistry, and an applicable method for cleaving amides used as directing groups in regioselective functionalization reactions has not been reported. Herein, we report direct catalytic alcoholysis of 8-aminoquinoline amides, which are highly effective directing groups in regioselective functionalization reactions. The reactions proceeded with a simple combination of substrates, air-stable catalysts, and alcohols, affording the corresponding esters in good yields with broad functional group tolerance. Highly chemoselective cleavage of the 8-aminoquinoline amides in the presence of related carbonyl functionalities and preliminary mechanistic studies are also described.. |
主要総説, 論評, 解説, 書評, 報告書等
主要学会発表等
学会活動
学協会役員等への就任
2021.07~2022.11, 日本薬学会 次世代を担う有機化学シンポジウム, 運営委員.
2014.03~2021.03, 日本薬学会 次世代を担う有機化学シンポジウム, 運営委員.
学会大会・会議・シンポジウム等における役割
2022.05.27~2019.05.28, 第20回次世代を担う有機化学シンポジウム, 実行委員長.
2019.05.31~2019.06.01, 第17回次世代を担う有機化学シンポジウム, 座長.
2018.10.26~2018.10.26, 近畿化学協会有機金属部会第3回例会, 運営スタッフ.
2018.09.26~2018.09.28, 第60回天然有機化合物討論会, 運営スタッフ.
2018.03.05~2018.03.05, Kyushu University-NTU Joint Symposium, 運営委員.
2018.03.25~2017.03.28, 日本薬学会第138年会, 座長(Chairmanship).
2017.06.03~2017.06.03, 第27回万有福岡シンポジウム, シンポジウム運営責任者.
2017.03.24~2017.03.27, 日本薬学会第137年会, 座長(Chairmanship).
2016.10.24~2016.10.26, The 6th Junior International Conference on Cutting-edge Organic Chemistry in Asia (JICCEOCA-6), 座長(Chairmanship).
2016.05.27~2016.05.28, 第14回次世代を担う有機化学シンポジウム, 座長(Chairmanship).
2016.03.26~2014.03.29, 日本薬学会第136年会, 座長(Chairmanship).
2014.11.22~2014.11.22, 第26回 若手研究者のためのセミナー, 座長(Chairmanship).
2014.05.23~2014.05.24, 第12回次世代を担う有機化学シンポジウム, 世話人.
2014.05.23~2014.05.24, 第12回次世代を担う有機化学シンポジウム, 座長(Chairmanship).
2014.03.28~2014.03.30, 日本薬学会第134年会, 座長(Chairmanship).
2013.12.07~2013.12.08, 第30回 日本薬学会九州支部大会, 座長(Chairmanship).
2013.03.28~2013.03.30, 日本薬学会第133年会, 座長(Chairmanship).
2012.12.08~2012.12.09, 第29回 日本薬学会九州支部大会, 座長(Chairmanship).
2012.03.29~2012.03.31, 日本薬学会第132年会, 座長(Chairmanship).
2011.05.27~2011.05.28, 第9回次世代を担う有機化学シンポジウム, 座長(Chairmanship).
2011.05.21~2011.05.21, 第21回万有福岡シンポジウム, 会場設営補助.
学術論文等の審査
年度 | 外国語雑誌査読論文数 | 日本語雑誌査読論文数 | 国際会議録査読論文数 | 国内会議録査読論文数 | 合計 |
---|---|---|---|---|---|
2022年度 | 2 | 0 | 0 | 0 | 2 |
2021年度 | 7 | 0 | 0 | 0 | 7 |
2020年度 | 10 | 0 | 0 | 0 | 10 |
2019年度 | 14 | 0 | 0 | 0 | 14 |
2018年度 | 10 | 0 | 0 | 0 | 10 |
2017年度 | 13 | 0 | 0 | 0 | 13 |
2016年度 | 10 | 0 | 0 | 0 | 10 |
2015年度 | 11 | 11 | |||
2014年度 | 12 | 12 | |||
2013年度 | 10 | 10 | |||
2012年度 | 9 | 9 | |||
2011年度 | 9 | 9 | |||
2010年度 | 10 | 10 | |||
2009年度 | 9 | 9 |
その他の研究活動
海外渡航状況, 海外での教育研究歴
Hawaii Convention Center, UnitedStatesofAmerica, 2010.12~2010.12.
Nanyang Technological University, Singapore, 2016.12~2016.12.
受賞
第20回(2020年度)GSC賞奨励賞, 新化学技術推進協会 グリーン・サステイナブル ケミストリー ネットワーク会議(JACI・GSCN会議), 2021.06.
第39回有機合成化学奨励賞, 有機合成化学協会, 2020.12.
日本化学会第33回若い世代の特別講演会, 日本化学会, 2019.03.
平成30年度有機合成化学協会九州山口支部優秀論文賞, 有機合成化学協会九州山口支部, 2018.11.
日本プロセス化学会2014サマーシンポジウム JSPC優秀賞, 日本プロセス化学会, 2014.08.
第6回武田科学振興財団薬科学シンポジウム ポスター賞, 武田科学振興財団, 2012.09.
第28回井上研究奨励賞, 井上科学振興財団, 2012.02.
有機合成化学協会研究企画賞(高砂香料工業研究企画賞), 有機合成化学協会, 2012.04.


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九大関連コンテンツ
pure2017年10月2日から、「九州大学研究者情報」を補完するデータベースとして、Elsevier社の「Pure」による研究業績の公開を開始しました。
九州大学知的財産本部「九州大学Seeds集」