| 1. |
Naoki Hirabayashi, Jun Hata, Yoshihiko Furuta, Tomoyuki Ohara, Mao Shibata, Yoichiro Hirakawa, Fumio Yamashita, Kazufumi Yoshihara, Takanari Kitazono, Nobuyuki Sudo, Toshiharu Ninomiya, Association Between Diabetes and Gray Matter Atrophy Patterns in a General Older Japanese Population: The Hisayama Study, Diabetes Care, 2022.06. |
| 2. |
Thyreau, Benjamin; Tatewaki, Yasuko; Chen, Liying; Takano, Yuji; Hirabayashi, Naoki; Furuta, Yoshihiko; Hata, Jun; Nakaji, Shigeyuki; Maeda, Tetsuya; Noguchi-Shinohara, Moeko; Mimura, Masaru; Nakashima, Kenji; Mori, Takaaki; Takebayashi, Minoru; Ninomiya, Toshiharu; Taki, Yasuyuki, Higher-resolution quantification of white matter hypointensities by large-scale transfer learning from 2D images on the JPSC-AD cohort, HUMAN BRAIN MAPPING, 10.1002/hbm.25899, 2022.05. |
| 3. |
Liu, Yingxu; Zhang, Ye; Thyreau, Benjamin; Tatewaki, Yasuko; Matsudaira, Izumi; Takano, Yuji; Hirabayashi, Naoki; Furuta, YoshihikTo; Jun, Hata; Ninomiya, Toshiharu; Taki, Yasuyuki, Altruistic Social Activity, Depressive Symptoms, and Brain Regional Gray Matter Volume: Voxel-Based Morphometry Analysis From 8,695 Old Adults, JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES, 10.1093/gerona/glac093, 2022.04. |
| 4. |
Masako Asada, Mao Shibata, Naoki Hirabayashi, Tomoyuki Ohara, Yoshihiko Furuta, Taro Nakazawa, Takanori Honda, Jun Hata, Masako Hosoi, Nobuyuki Sudo, Ken Yamaura, Toshiharu Ninomiya, Association between chronic low back pain and regional brain atrophy in a Japanese older population: the Hisayama Study., Pain., 10.1097/j.pain.0000000000002612., 2022.03. |
| 5. |
Taro Nakazawa, Tomoyuki Ohara, Naoki Hirabayashi, Yoshihiko Furuta, Jun Hata, Mao Shibata, Takanori Honda, Takanari Kitazono, Tomohiro Nakao, Toshiharu Ninomiya, Multiple-region grey matter atrophy as a predictor for the development of dementia in a community: the Hisayama Study, Journal of Neurology, Neurosurgery, and Psychiatry, 10.1136/jnnp-2021-326611, 2021.10. |
| 6. |
Tomoyuki Ohara, Daigo Yoshida, Jun Hata, Mao Shibata, Takanori Honda, Yoshihiko Furuta, Naoki Hirabayashi, Takanari Kitazono, Tomohiro Nakao, Toshiharu Ninomiya, Current status of the certification of long-term care insurance among individuals with dementia in a Japanese community: The Hisayama Study, Psychiatry and Clinical Neurosciences, 10.1111/pcn.13204, 2021.04. |
| 7. |
Shibata M, Ohara T, Hosoi M, Jun H, Yoshida D, Hirabayashi N, Morisaki Y, Nakazawa T, Mihara A, Nagata T, Oishi E, Anno K, Sudo N, Ninomiya T, Emotional loneliness is associated with a risk of dementia in a general Japanese older population: the Hisayama Study, The Journals of Gerontology, Series B: Psychological Sciences and Social Sciences, 2020.11. |
| 8. |
Yamasaki K, Hata J, Furuta Y, Hirabayashi N, Ohara T, Yoshida D, Hirakawa Y, Nakano T, Kitazono T, Ninomiya T, Association of Albuminuria With White Matter Hyperintensities Volume on Brain Magnetic Resonance Imaging in Elderly Japanese - The Hisayama Study, Circulation Journal, 2020.05. |
| 9. |
Tomoyuki Ohara, Yoshihiko Furuta, Naoki Hirabayashi, Jun Hata, Yoichiro Hirakawa, Takanori Honda, Daigo Yoshida, Mao Shibata, Takanari Kitazono, Toshiharu Ninomiya, Elevated serum glycated albumin and glycated albumin : hemoglobin A1c ratio were associated with hippocampal atrophy in a general elderly population of Japanese
The Hisayama Study, Journal of Diabetes Investigation, 10.1111/jdi.13220, 2020.01, Aims/Introduction: To investigate the association of alternative glycemic measures – namely, serum glycated albumin (GA), hemoglobin A1c (HbA1c) and the GA : HbA1c ratio – with global brain and hippocampal atrophy in a general elderly Japanese population. Materials and Methods: A total of 1,278 Japanese individuals aged ≥65 years in a community participated in brain magnetic resonance imaging scanning and screening examination of health status in 2012. We measured total brain volume (TBV), hippocampal volume (HV) and intracranial volume (ICV) using the data from the magnetic resonance imaging examination. The association of each glycemic measure with the ratios of TBV : ICV (an indicator of global brain atrophy) and HV : ICV (an indicator of hippocampal atrophy) was examined by analysis of covariance. Results: The mean values of the TBV : ICV and HV : ICV ratios decreased significantly with elevating serum GA levels and GA : HbA1c ratio levels (all P for trend 1c levels, after adjusting for age, sex, low education, systolic blood pressure, antihypertensive medication, diabetes mellitus, serum total cholesterol, electrocardiogram abnormalities, body mass index, smoking habits, alcohol drinking habits and regular exercise. These significant associations were still observed in the sensitivity analysis after excluding individuals with mild cognitive impairment and dementia. In addition, increased serum GA levels and the GA : HbA1c ratio levels, but not HbA1c, were closely associated with lower mean values of the TBV : ICV and HV : ICV ratios, irrespective of the presence or absence of diabetes mellitus. Conclusions: The present study suggests that higher serum GA and higher GA : HbA1c ratio are significantly associated with global brain and hippocampal atrophy.. |
| 10. |
Tomohiro Yubi, Jun Hata, Tomoyuki Ohara, Naoko Mukai, Yoichiro Hirakawa, Daigo Yoshida, Seiji Gotoh, Naoki Hirabayashi, Yoshihiko Furuta, Tetsuro Ago, Takanari Kitazono, Yutaka Kiyohara, Toshiharu Ninomiya, Prevalence of and risk factors for cerebral microbleeds in a general Japanese elderly community, Neurology: Clinical Practice, 10.1212/CPJ.0000000000000464, 8, 3, 223-231, 2018.06, Background We investigated the prevalence of and risk factors for cerebral microbleeds (CMBs) in a cross-sectional study of a general population of Japanese elderly. Methods In 2012, brain MRI scanning at 1.5T and comprehensive health examination were conducted for 1281 residents aged 65 years or older. CMBs were defined as ovoid hypointensity lesions less than 10 mm in diameter on T2-weighted images and classified into deep/infratentorial or lobar CMBs. Age- and sex-specific and overall prevalence of CMBs were estimated, and the associations of traditional cardiovascular risk factors and APOE polymorphism with the presence of CMBs were examined using a logistic regression analysis. Results The crude prevalences of total, deep/infratentorial, and lobar CMBs were 18.7% (n = 240), 13.5% (n = 173), and 9.6% (n = 123), respectively. The prevalence of total CMBs was 23.0% in men and 15.5% in women and increased with aging in both sexes (both p for trend |
| 11. |
Naoki Hirabayashi, Jun Hata, Tomoyuki Ohara, Naoko Mukai, Masaharu Nagata, Mao Shibata, Seiji Gotoh, Yoshihiko Furuta, Fumio Yamashita, Kazufumi Yoshihara, Takanari Kitazono, Nobuyuki Sudo, Yutaka Kiyohara, Toshiharu Ninomiya, Association between diabetes and hippocampal atrophy in Elderly Japanese
The Hisayama study, Diabetes care, 10.2337/dc15-2800, 39, 9, 1543-1549, 2016.09, OBJECTIVE To investigate the association between diabetes and brain or hippocampal atrophy in an elderly population. RESEARCH DESIGN AND METHODS A total of 1,238 community-dwelling Japanese subjects aged ≥65 years underwent brain MRI scans and a comprehensive health examination in 2012. Total brain volume (TBV), intracranial volume (ICV), and hippocampal volume (HV) were measured using MRI scans for each subject. We examined the associations between diabetes-related parameters and the ratios of TBV to ICV (an indicator of global brain atrophy), HV to ICV (an indicator of hippocampal atrophy), and HV to TBV (an indicator of hippocampal atrophy beyond global brain atrophy) after adjustment for other potential confounders. RESULTS Themultivariable-adjustedmean values of the TBV-to-ICV,HV-to-ICV, and HV-to-TBV ratios were significantly lower in the subjects with diabetes compared with those without diabetes (77.6%vs. 78.2%for the TBV-to-ICV ratio, 0.513%vs. 0.529%for the HV-to-ICV ratio, and 0.660% vs. 0.676% for the HV-to-TBV ratio; all P |
