受賞区分：国内学会・会議・シンポジウム等の賞 

記述言語：英語   出版者・発行元：Journal of Clinical Medicine  

Background: Preservation of posterior occlusal support is critical for maintaining residual dentition in partially edentulous patients. Although implant-supported restorations are widely used, long-term evidence on their role in preventing tooth loss remains limited. Methods: A retrospective cohort study of 225 patients (80 males, 145 females; mean age 53 ± 9 years) who received posterior implant-supported restorations, with a mean follow-up of 21 years. Post-treatment occlusal support was classified using the Eichner classification. Tooth and implant loss were recorded. Associations between residual occlusal support and tooth loss were analyzed using Pearson’s chi-square test, with thresholds of ≥1, ≥2, or ≥3 teeth lost. Multivariate logistic regression analyses adjusted for age and gender were performed to evaluate the independent association of the Eichner classification. Results: After prosthesis delivery, 159 patients were classified as Eichner A, 48 as B1, 16 as B2, and 2 as B3. The mean number of lost teeth was 2.4, and 35 implants failed in 22 patients. Tooth loss ≥3 occurred more frequently in the Eichner B groups than in A. (48.5% vs. 34.0%). In multivariate analyses, Eichner classification significantly predicted loss of ≥3 teeth (adjusted OR = 1.83; 95% CI: 1.00–3.33; p = 0.048), but not ≥1 or ≥2 teeth. Conclusions: Posterior implant therapy provides durable occlusal support and contributes to long-term preservation of residual dentition. Patients with limited occlusal support remain at a higher risk of substantial tooth loss, even after adjustment for age and gender. The Eichner classification represents a practical clinical tool for evaluating occlusal support and predicting long-term prognosis in partially edentulous patients.

DOI： 10.3390/jcm14248939

Web of Science

Scopus

PubMed

担当区分：筆頭著者   記述言語：英語   出版者・発行元：Biointerphases  

The long-term stability of dental implants is significantly influenced by their resistance to foreign factors in the peri-implant epithelium (PIE). Despite this, enhancing the sealing properties at the implant-PIE interface continues to be an unmet clinical need. Ti-6Al-4V (Ti64) alloy has higher tensile strength and hardness than pure titanium. This study was to verify whether hydrothermal treatment of Ti64 alloy implants with distilled water (HT-DW) or calcium chloride (CaCl2) solution (HT-Ca) could improve the sealing of the PIE around Ti64 implants. The existence of calcium (Ca) on the surface of HT-Ca implants was confirmed using x-ray photoelectron spectroscopy and synchrotron-based x-ray absorption fine structure techniques. These data showed that the surface was oxidized, and Ca existed in the form of anhydrous CaCl2 and calcium titanate. Laminin-332 (Ln), which is an essential component of epithelial adhesion structures, was observed between all types of implants and the PIE, 4 weeks after implantation in rat maxillae. Ln distribution over the entire epithelial interface was similar for the HT-Ca implant and a natural tooth. Moreover, the HT-Ca implant inhibited foreign body penetration, which indicated stronger gingival sealing at the implant-PIE interface, compared with the untreated and HT-DW implants. We also investigated the attachment of mouse-derived gingival epithelial cells (GE1). GE1 adherence was stronger and Ln expression levels were higher for HT-Ca plates compared with the untreated and HT-DW plates. Our results demonstrate that hydrothermal treatment of Ti64 implants with CaCl2 solution facilitates the growth of an effective soft tissue seal around the implant.

DOI： 10.1116/6.0004359

Web of Science

Scopus

PubMed

記述言語：英語   掲載種別：研究論文（学術雑誌）  

The enhancement of oral epithelial adhesion to the trans-mucosal material of dental implants may improve their long-term stability. The aim of this study is to investigate whether hydrothermal treatment with distilled water (HT-DW) applied to a Ti-6Al-4V (Ti64) alloy could improve epithelial cellular attachment. We hypothesized that this treatment would enhance the adsorption of proteins and the adhesion of gingival epithelial GE1 cells. This treatment changed the surface crystal structure into an anatase type of titanium oxide without an apparent change of surface roughness or topography. Nitrogen was not detected on the HT-DW-treated Ti64, which indicates decontamination. HT-DW-treated Ti64 exhibited a hydrophilic surface with a less than 10° angle of water contact. Adsorption of laminin-332 to the HT-DW-treated Ti64 was significantly greater than that of the untreated Ti64 plates (64). The number of GE1 cells on the HT-DW-treated Ti64 at 1 and 3 days was significantly lower than that on 64; however, cell adhesion strength on HT-DW was greater, with a higher expression of integrin β4, compared with 64. This indicates that the HT-DW treatment of Ti64 improves the integration of GE1 cells, which might facilitate the development of a soft tissue barrier around the implant.

リポジトリ公開URL： https://hdl.handle.net/2324/7172607

開催年月日： 2025年12月

記述言語：日本語  

開催地：岡山  

開催年月日： 2025年5月

記述言語：日本語  

開催地：長崎  

開催年月日： 2021年6月

記述言語：日本語  

開催地：web   国名：日本国  

外来因子の侵入に対するインプラント周囲上皮(PIE)の封鎖性は天然歯より劣ることが報告されているが，インプラントの粘膜貫通部における封鎖性向上を目的とした製品は少ない．そこで本研究では，チタン合金に親水性を付与し高い骨伝導能をもたらす水熱処理が，外来因子に対する上皮の封鎖性を高めるという仮説をたて検証することとした．チタン合金(Ti-6Al-4V)製のプレートおよびインプラントを使用し，蒸留水にて水熱処理したチタン(64HT)を作製した．対照群は未処理純チタン(CP)，未処理チタン合金(64)とした．チタンプレートの解析では，まず走査型電子顕微鏡(SEM)および粗さ測定を行った．次に，表面性状評価のためレーザーラマン分光装置による結晶構造解析，X線電子分光装置(XPS)による元素解析および水との接触角測定を行った．さらに，基底膜の構成要素であるラミニン332(Ln)を用いて各処理群に対する吸着量の比較を行った．培養実験では，マウス由来歯肉上皮細胞株GE1をプレート上で培養し，細胞の増殖能・接着能を評価した．また，Lnレセプターである細胞膜上のインテグリンβ4(Inβ4)を標識し観察を行った．動物実験では，4週齢雄性Wistarラット上顎右側第一臼歯を抜去し，2週間後にインプラントを埋入した．埋入4週後にLnの局在を観察し，西洋ワサビペルオキシダーゼ(HRP)をインプラント周囲溝に滴下し浸透の程度から外来因子に対する上皮封鎖能を評価した．(九州大学動物実験倫理委員会承認A19-385-0)．水熱処理はSEMで確認できる倍率の範囲ではプレートの表面形状を変化させずに親水性を付与し，Lnの吸着量も増大させた．培養実験から，64HTにおけるInβ4の明瞭な発現を認め，上皮細胞の接着能は対照群より有意に向上していた．PIEの観察から，64HTは対照群と比較してLnの発現が強く深層まで認め，HRPの侵入深度は有意に抑制された．以上の結果より，純水による水熱処理はチタン合金に対するPIEの封鎖性を向上させることが示唆された．

担当区分：筆頭著者   記述言語：日本語   掲載種別：記事・総説・解説・論説等（学術雑誌）