Kyushu University Academic Staff Educational and Research Activities Database
List of Books
Jiro Nakayama Last modified date:2023.11.27

Professor / Division of Systems Bioengineering / Department of Bioscience and Biotechnology / Faculty of Agriculture

1. Basit Yousuf, Keika Adachi, Jiro Nakayama, Biotechnological Applications of Quorum Sensing Inhibitors, Springer Nature, Chapter 9. Developing anti-virulence chemotherapies by exploiting the diversity of mocirobial quorum sensing systems, 2018.06.
2. Ravindra Pal Singh, Said E. Desouky, Jiro Nakayama, Quorum quenching strategy targeting gram-positive pathogenic bacteria, Springer New York LLC, 10.1007/5584_2016_1, 2016.01, Quorum sensing (QS) is a cell density-dependent regulatory system that orchestrates the group behavior of unicellular organisms by synchronizing the expression of certain gene(s) within the clonal community of same species. Bacterial pathogens often employ QS system to establish efficiently an infection. A large part of low GC Gram-positive bacteria belonging to phylum Firmicutes use thiolactone/lactone peptides as communication signals so-called autoinducing peptides (AIPs) to coordinate QS circuit. In particular, QS of staphylococci, enterococci, and clostridia have been intensively studied in terms of alternative target of antipathogenic chemotherapy independent of bactericidal antibiotics. Thus far, a number of quorum quenching (QQ) agents that targeting the QS circuit of these Gram-positive pathogens have been developed by random screening of natural compounds or rationale design of AIP antagonists. This review summarizes those QQ agents and previews their potential as post-antibiotic drugs..
3. Ravindra Pal Singh, Jiro Nakayama, Quorum Sensing vs Quorum Quenching: A Battle with no end in Sight (Development of quorum-sensing inhibitors targeting the fsr system of enterococcus faecalis), Springer, 10.1007/978-81-322-1982-8__25, 319-326, 2015.01, Enterococcus spp. can cause illnesses such as bacteremia, endocarditis, urinary tract infections, posttreatment endophthalmitis, and endodontic infections (Murray 2000; Marothi et al. 2005). Medical treatment of these infectious diseases depends largely on bactericidal or bacteriostatic antibiotics. However, frequent use of such antibiotics has led to the development of drug-resistant bacterial strains, which are difficult to treat (Marothi et al. 2005; Murray 2000). As a result, the blockage of bacterial quorum-sensing (QS) systems has attracted attention owing to its potential to attenuate bacterial virulence without inducing bactericidal pressures that lead to drug resistance. This approach, called quorum quenching (QQ), can be undertaken partially or completely independently of antibiotic treatment. Among several QQ strategies, the use of QS inhibitors (QSIs), which are small molecules that have no adverse effects on bacteria, offers advantages in terms of drug delivery and decreased damage to commensal microbiota..
4. Ravindra Pal Singh, Jiro Nakayama, Quorum Sensing vs Quorum Quenching: A Battle with no end in Sight (Quorum-sensing systems in enterococci), Springer, 10.1007/978-81-322-1982-8__14, 155-163, 2015.01, Enterococcus is a genus of Gram-positive bacteria that is ubiquitous in natural ecosystems, plants, and animals. Some species of Enterococcus are present in the normal gastrointestinal bacterial community. However, others notably Enterococcus faecalis and Enterococcus faecium often cause opportunistic infections such as bacteremia, endocarditis, urinary tract infections, posttreatment endodontic infections, and endophthalmitis (Arias et al. 2010). Bacteria often use quorum sensing (QS) systems to control the expression of certain virulence genes and establish infection efficiently (Waters and Bassler 2005)..
5. 中山 二郎, 庄島あかね, Gianfranco Donelli, Microbial Biofilms, Springer, 2014.09.
6. Sueharu Horinouchi, Kenji Ueda, Jiro Nakayama, Tsukasa Ikeda, Comprehensive Natural Products II: Chemistry and Biologym, Cell-to-cell communications among microorganisms, Elsevier, Vol.4, 283-337, 2010.03.
7. Sueharu Horinouchi, Kenji Ueda, Jiro Nakayama, Tsukasa Ikeda, Cell-to-cell communications among microorganisms, Elsevier Ltd, 4, 283-337, 2010.03.
8. Shohei Sakuda, Makoto Ono, Hiroyuki Ikeda, Masaru Sakurada, Jiro Nakayama, Akinori Suzuki, Akira Isogai, Aflastatins
New streptomyces metabolites that inhibit aflatoxin biosynthesis
, CRC Press, 185-200, 1999.01, Aflatoxins are a group of mycotoxins produced by some strains of the fungi, Aspergillus parasiticus, Aspergillus flavus, and Aspergillus nomius. These aflatoxin-producing fungi are present ubiquitously in the world, but they don’t always produce the toxin. Under some environmental conditions of high temperature and humidity, especially at tropical or subtropical zones, they infect agricultural products such as peanuts or corn, and produce aflatoxins not only on the outside, but also on the inside. Aflatoxins were first found in 1960 as toxic metabolites produced by A. flavus which killed numerous turkeys in England. They also were shown to have an extremely potent carcinogenicity toward mammals and found as contaminates in a wide variety of food commodities. Aflatoxin is now generally recognized not only as an extremely toxic contaminant in foods and feeds, but also as one of the certain risk factors for liver cancer in humans. 1 Thus, control and management of aflatoxins have become issues of concern..