九州大学 研究者情報
論文一覧
黒瀬 等(くろせ ひとし) データ更新日:2020.06.18

教授 /  薬学研究院 臨床薬学部門 薬効安全性学


原著論文
1. Parichatikanond W, Luangmonkong T, Mangmool S, Kurose H., Therapeutic targets for the treatment of cardiac fibrosis and cancer: Focusing on TGF-β signaling. , Front Cardiovasc Med, 10.3389/fcvm.2020.00034., 7:34, 2020.03.
2. Yoshimura C, Nagasaka A, Kurose H, Nakaya M., Efferocytosis during myocardial infarction., J Biochem., 10.1093/jb/mvaa051. , in press, 2020.04.
3. Horii Y, Nakaya M, Ohara H, Nishihara H, Watari K, Nagasaka A, Nakaya T, Sugiura Y, Okuno T, Koga T, Tanaka A, Yokomizo T, Kurose H., Leukotriene B4 receptor 1 exacerbates inflammation following myocardial infarction., FASEB J. , 10.1096/fj.202000041R., 34(6):8749-8763., 2020.06.
4. Iezaki T, Fukasawa K, Horie T, Park G, Robinson S, Nakaya M, Fujita H, Onishi Y, Ozaki K, Kanayama T, Hiraiwa M, Kitaguchi Y, Kaneda K, Yoneda Y, Takarada T, Guo XE, Kurose H, Hinoi E., The MAPK Erk5 is necessary for proper skeletogenesis involving a Smurf-Smad-Sox9 molecular axis. , Development., 10.1242/dev.164004., 145(14). pii: dev164004., 2018.07.
5. Kim TH, Yang YM, Han CY, Koo JH, Oh H, Kim SS, You BH, Choi YH, Park TS, Lee CH, Kurose H, Noureddin M, Seki E, Wan YY, Choi CS, Kim SG., Gα12 ablation exacerbates liver steatosis and obesity by suppressing USP22/SIRT1-regulated mitochondrial respiration., J Clin Invest., 10.1172/JCI97831, 128, 12, 5587-5602, 2018.12.
6. Mangmool S, Parichatikanond W, Kurose H., Therapeutic Targets for Treatment of Heart Failure: Focus on GRKs and β-Arrestins Affecting βAR Signaling., Front Pharmacol., 10.3389/fphar.2018.01336, 9, 1336, 2018.11.
7. Mangmool S, Denkaew T, Parichatikanond W, Kurose H., β-Adrenergic receptor and insulin resistance in the heart., Biomolecules & Therapeutics, doi: 10.4062/biomolther.2016.128., 25, 1, 44-56, invited review, 2017.01.
8. Kurose H, Mangmool S., Myofibroblasts and inflammatory cells as players of cardiac fibrosis., Archives of Pharmacal Research, 39, 8, 1100-1113, invited review, 2016.08.
9. Koshimizu T, Honda K, Nagaoka-Uozumi S, Ichimura A, Kimura I, Nakaya M, Sakai S, Shibata K, Ushijima K, Fujimura A, Hirasawa A, Kurose H, Tsujimoto G, Tanoue A, and Takano Y., Suppression of morphine tolerance and adenylate cyclase sensitization by CRISPR-mediated microdeletion at Avpr1b encoding V1b vasopressin receptor. , Nature Neuroscience, doi: 10.1038/s41593-018-0144-y., 21, 6, 820-833, 2018.06.
10. Takeda T, Komiya Y, Koga T, $Ishida T, Ishii Y, Kikuta Y, Nakaya M, Kurose H, Yokomizo T, Shimizu T, Uchi H, Furue M, Yamada H., Dioxin-induced increase in leukotriene B4 biosynthesis through the aryl hydrocarbon receptor and its relevance to hepatotoxicity owing to neutrophil infiltration., Journal of Biological Chemistry , doi: 10.1074/jbc.M116.764332., 292, 25, 10586-10599, 2017.06.
11. @Nagasaka A, Mogi C, #Ono H, #Nishi T, #Horii Y, #Ohba Y, Sato K, @Nakaya M, Okajima F, @Kurose H., The proton-sensing G protein-coupled receptor T-cell death-associated gene 8 (TDAG8) shows cardioprotective effects against myocardial infarction. , Scientific Report, doi: 10.1038/s41598-017-07573-2, 7, 1月, 7812, 2017.06.
12. Hitoshi Kurose, Nakaya Michio, Watari K, Tajima M, Nakaya T, Matsuda S, Ohara H, Nishihara H, Yamaguchi H, Hashimoto A, Nishida M, AKIOMI NAGASAKA, Horii Y, Ono H, Inoue R, Tsuda M, Kazuhide Inoue, Tanaka A, Kuroda M, Cardiac myofibroblast engulfment of dead cells facilitates recovery after myocardial infarction., J Clin Invest, 10.1172/JCI83822, 127, 1, 383-401, 2017.01, Myocardial infarction (MI) results in the generation of dead cells in the infarcted area. These cells are swiftly removed by
phagocytes to minimize inflammation and limit expansion of the damaged area. However, the types of cells and molecules
responsible for the engulfment of dead cells in the infarcted area remain largely unknown. In this study, we demonstrated that
cardiac myofibroblasts, which execute tissue fibrosis by producing extracellular matrix proteins, efficiently engulf dead cells.
Furthermore, we identified a population of cardiac myofibroblasts that appears in the heart after MI in humans and mice.
We found that these cardiac myofibroblasts secrete milk fat globule-epidermal growth factor 8 (MFG-E8), which promotes
apoptotic engulfment, and determined that serum response factor is important for MFG-E8 production in myofibroblasts.
Following MFG-E8–mediated engulfment of apoptotic cells, myofibroblasts acquired antiinflammatory properties. MFG-E8
deficiency in mice led to the accumulation of unengulfed dead cells after MI, resulting in exacerbated inflammatory responses
and a substantial decrease in survival. Moreover, MFG-E8 administration into infarcted hearts restored cardiac function and
morphology. MFG-E8–producing myofibroblasts mainly originated from resident cardiac fibroblasts and cells that underwent
endothelial-mesenchymal transition in the heart. Together, our results reveal previously unrecognized roles of myofibroblasts
in regulating apoptotic engulfment and a fundamental importance of these cells in recovery from MI..
13. Hitoshi Kurose, Fukuda H, Ito S, Watari K, Mogi C, Arisawa M, Okajima F, Shuto S, Identification of a Potent and Selective GPR4 Antagonist as a Drug Lead for the Treatment of Myocardial Infarction., ACS Med Chem Lett, 7, 5, 493-497, 2016.05.
14. Sakamoto S., Nagamitsu R, Matsuura Y, Tsuneura Y, Hitoshi Kurose, Hiroyuki Tanaka, Morimoto S, A new approach of indirect enzyme-linked immunosorbent assay for determination of D-glutamic acid through in situ conjugation., J Immunoassay Immunochem., 10.1080/15321819.2015.1135161, 37, 3, 296-306, 2016.05.
15. Hitoshi Kurose, Nishimura A, Sunggip C,, Hidetoshi Saitoh, Shimauchi T, Numaga-Tomita T, Katsuya Hirano, Ide Tomomi, Boeynaems J-M, Takahiro Masuda et al., Robaye B, Kazuhide Inoue, Motohiro Nishida, Purinergic P2Y6 receptors heterodimerize with angiotensin AT1 receptors to promote angiotensin II-induced hypertension., Sci Signal, doi: 10.1126/scisignal.aac9187, 9, ra7, 2016.05.
16. Hitoshi Kurose, Tobo A, Tobo M, Nakakura T, Ebara M, Tomura H, Mogi, Im D-S, Murata N, Kuwabara A, Ito S, Fukuda H, Arisawa M, Shuto S, Nakaya Michio, Okajima F, Characterization of imidazopyridine compounds as negative allosteric modulators of proton-sensing GPR4 in extracellular acidification-induced responses., PLoS One, 10.1371/journal.pone.0129334, 10, 6, e0129334, 2015.06.
17. Yuki Ohba, Nakaya Michio, Kenji Watari, AKIOMI NAGASAKA, Hitoshi Kurose, GRK6 phosphorylates IκBα at Ser32/Ser36 and enhances TNF-α-induced inflammation via the activation of NF-κB signaling., Biochem Biophys Res Commun., 10.1016/j.bbrc.2015.04.027, 461, 2, 307-313, 2017.05.
18. Gasser A, Brogi S, Kyoji Urayama, Toshihide Nishi, Hitoshi Kurose, Tafi A, Ribeiro N, Désaubry L, Nebigil CG, Discovery and cardioprotective effects of the first non-Peptide agonists of the g protein-coupled prokineticin receptor-1., PLoS One, 10.1371/journal.pone.0121027, 10, 4, e0121027, 2015.04.
19. Watari Kenji, Nakaya Michio, Hitoshi Kurose, Multiple functions of G protein-coupled receptor kinases., Journal of Molecular Signaling, 9, 1, 1, 2014.04.
20. Jin M, Min C, Zheng M, Cho DI, Cheong SJ, Hitoshi Kurose, Kim KM, Multiple signaling routes involved in the regulation of adenylyl cyclase and extracellular regulated kinase by dopamine D(2) and D(3) receptors., Pharmacol. Res., 67, 1, 31-41, 2013.03.
21. Nakaya Michio, Tajima M, Kosako H, Nakaya N, Hashimoto A, Watari K, Nishihara H, Ohba M, Komiya S, Tani N, Motohiro Nishida, Taniguchi H, Sato Y, Matsumoto M, TSUDA MAKOTO, Kuroda M, Kazuhide Inoue, Hitoshi Kurose, GRK6-deficiency in mice causes autoimmune disease due to impaired apoptotic cell clearance. , Nat. Commun., 4, 1532, 2003.03.
22. Nakaya Michio, Tajima M, Kosako H, Nakaya N, Hashimoto A, Watari K, Nishihara H, Ohba M, Komiya S, Tani N, Motohiro Nishida, Taniguchi H, Sato Y, Matsumoto M, TSUDA MAKOTO, Kuroda M, Kazuhide Inoue, Hitoshi Kurose, GRK6-deficiency in mice causes autoimmune disease due to impaired apoptotic cell clearance. , Nat. Commun., 4, 1532, 2013.03.
23. Makita N, Kabasawa Y, Otani Y, Firman F, Sato J, Hashimoto M, Nakaya Michio, Nishihara H, Nangaku M, Hitoshi Kurose, Ohwada T, Iiri T, Attenuated desensitization of β-adrenergic receptor by water-soluble N-nitrosamines that induce S-nitrosylation without nitric oxide release., Circ. Res., 112, 1, 327-334, 2013.02.
24. Masubuchi Y, Nakagawa Y, Ma J, Sasaki T, Kitamura T, Yamamoto Y, Hitoshi Kurose, Kojima I, Shibata H, A Novel Regulatory Function of Sweet Taste-Sensing Receptor in Adipogenic Differentiation of 3T3-L1 Cells., PLoS ONE, 8, 1, e54500-e54500, 2013.01.
25. Nakaya Michio, Chikura S, Watari K, Mizuno N, Mochinaga K, Mangmool S, Koyanagi Satoru, shigehiro ohdo, Sato Y, Ide Tomomi, Motohiro Nishida, Hitoshi Kurose, Induction of cardiac fibrosis by β-blocker in G protein-independent and GRK5/β-arrestin2-dependent signaling pathways., J. Biol. Chem. , 287, 42, 35669-35677, 2012.10.
26. Motohiro Nishida, Sawa T, Kitajima N, Ono K, Inoue H, Ihara H, Motohashi H, Yamamoto M, Suematsu M, Hitoshi Kurose, van der Vliet A, Freeman BA, Shibata T, Uchida K, Kumagai Y, Akaike T., Hydrogen sulfide anion regulates redox signaling via electrophile sulfhydration., Nat Chem Biol. , 8, 8, 714-724, 2012.03.
27. Fujino T, Ide Tomomi, Yoshida M, Onitsuka K, Tanaka A, Hata Y, Motohiro Nishida, Takehara T, Kanemaru T, Kitajima N, Takazaki S, Hitoshi Kurose, Dongchon Kang, Kenji Sunagawa, Recombinant Mitochondrial Transcription Factor A Protein Inhibits Nuclear Factor of Activated T Cells Signaling and Attenuates Pathological Hypertrophy of Cardiac Myocytes., Mitochondrion, 12, 4, 449-458, 2012.07.
28. Kan-o M, RYU TAKEYA, Abe T, Kitajima N, Motohiro Nishida, Tominaga R, Hitoshi Kurose, Hideki Sumimoto, Mammalian formin Fhod3 plays an essential role in cardiogenesis byorganizing myofibrillogenesis., Biology Open, 1, 9, 899-896, 2012.04.
29. Ibrahim IA, Kurose H., Beta-arrestin-mediated signaling improves the efficacy of therapeutics., J Pharmacol Sci., 118, 4, 408-412, 2012.04.
30. Mangmool S, Kurose H., Gi/o protein-dependent and -independent actions of Pertussis toxin (PTX)., Toxins (Basel). , 3, 7, 884-899, 2011.09.
31. Kurose, H., Atypical actions of G protein-coupled receptor kinases., Biomolecule and Therapeutics , 19, 4, 390-397, 2011.08.
32. Nishioka K, Nishida N, Ariyoshi M, Jian Z, Saiki S, Hirano M, Nakaya M, Sato Y, Kita S, Iwamoto T, Hirano K, Inoue R, Kurose H., Cilostazol Suppresses Angiotensin II-Induced Vasoconstriction via Protein Kinase A-mediated Phosphorylation of the Transient Receptor Potential Canonical 6 Channel., Arterioscler. Thromb. Vasc. Biol. , 31, 10, 2278-2286, 2011.09.
33. Kitajima N, Watanabe K, Morimoto S, Sato Y, Kiyonaka S, Hoshijima M, Ikeda Y, Nakaya M, Ide T, Mori Y, Kurose H, Nishida M., TRPC3-mediated Ca2+ influx contributes to Rac1-mediated production of reactive oxygen species in MLP-deficient mouse hearts., Biochem Biophys Res Commun., 409, 1, 108-113, 2011.05.
34. Tomonari M, To H, Nishida M, Mishima T, Sasaki H, Kurose H., Mechanism of the cardioprotective effects of docetaxel pre-administration against adriamycin-induced cardiotoxicity., J Pharmacol. Sci., 115, 3, 336-345, 2011.06.
35. Nishida M, Ogushi M, Suda R, Toyotaka M, Saiki S, Kitajima N, Nakaya M, Kim KM, Ide T, Sato Y, Inoue K, Kurose H., Heterologous down-regulation of angiotensin type 1 receptors by purinergic P2Y2 receptor stimulation through S-nitrosylation of NF-kB., Proc Natl Acad Sci USA 108 (16), 6662-6667 (2011), 108, 16, 6662-6667, 2011.04.
36. Matsuzaki S, Ishizuka T, Hisada T, Aoki H, Komachi M, Ichimonji I, Utsugi M, Ono A, Koga Y, Dobashi K, Kurose H, Tomura H, Mori M, Okajima F., Lysophosphatidic acid inhibits CC chemokine ligand 5/RANTES production by blocking IRF1-mediated gene transcription in human bronchial epithelial cells. , J Immunol. , 185, 8, 4863-4872, 2010.08.
37. Kinoshita H, Kuwahara K, Nishida M, Jiang Z, Rong X, Kiyonaka S, Kuwabara Y, Kurose H, Inoue R, Mori Y, Nakagawa Y, Usami S, Fujiwara M, Yamada Y, Minami T, Ueshima K, Nakao K., Inhibition of TRPC6 channel actvitiy contributes to the antihypertrophic effects of natriuretic peptides-guanylyl cyclase-A signaling in the heart. , Circ Res., 106, 12, 1849-1860 , 2010.06.
38. Nishida M, Suda R, Nagamatsu Y, Tanabe S, Onohara N, Nakaya M, Kanaho Y, Shibata T, Uchida K, Sumimoto H, Sato Y, Kurose H., Pertussis toxin up-regulates angiotensin type 1 receptors through Toll-like receptor 4-mediated Rac activation., J Biol Chem. , 285, 20, 15268-15277, 2010.05.
39. Nishida M, Watanabe K, Sato Y, Nakaya M, Kitajima N, Ide T, Inoue R, Kurose H.: , Phosphorylation of TRPC6 channels at Thr69 is required for anti-hypertrophic effects of phosphodiesterase 5 inhibition., J Biol Chem. (2010), 286, 17, 13244-13253 , 2010.04.
40. Saito M, Tanaka H, Sasaki M, Kurose H, Nakahata N. , Involvement of aquaporin in thromboxane A2 receptor-mediated, G12/13/RhoA/NHE-sensitive cell swelling in 1321N1 human astrocytoma cells., Cell Signal. , 22, 1, 41-6, 2010.01.
41. Kimura T, Tomura H, Sato K, Ito M, Matsuoka I, Im DS, Kuwabara A, Mogi C, Itoh H, Kurose H, Murakami M, Okajima F., Mechanism and role of high density lipoprotein-induced activation of AMP-activated protein kinase in endothelial cells., J Biol Chem., 285, 7, 4387-97 , 2010.02.
42. Guilini C, Urayama K, Turkeri G, Dedeoglu DB, Kurose H, Messaddeq N, Nebigil CG., Divergent roles of prokineticin receptors in the endothelial cells: angiogenesis and fenestration., Am J Physiol Heart Circ Physiol. , 298, 3, H844-52 , 2010.03.
43. Saito M, Tanaka H, Sasaki M, Kurose H, Nakahata N., Involvement of aquaporin in thromboxane A2 receptor-mediated, G12/13/RhoA/NHE-sensitive cell swelling in 1321N1 human astrocytoma cells., Cell Signal., Vol. 22, 41-46, 2010.01.
44. Kimura T, Tomura H, Sato K, Ito M, Matsuoka I, Im DS, Kuwabara A, Mogi C, Itoh H, Kurose H, Murakami M, Okajima F., Mechanism and role of high density lipoprotein-induced activation of AMP-activated protein kinase in endothelial cells., J Biol Chem, Vol. 285, 4789-4797, 2010.02.
45. Guilini C, Urayama K, Turkeri G, Dedeoglu DB, Kurose H, Messaddeq N, Nebigil CG., Divergent roles of prokineticin receptors in the endothelial cells: angiogenesis and fenestration., Am J Physiol Heart Circ Physiol., Vol. 298, H844-852, 2010.03.
46. Cho D, Zheng M, Min C, Ma L, Kurose H, Park JH, Kim KM., Agonist-induced endocytosis and receptor phosphorylation mediate resensitization of dopamine D2 receptors., Mol Endocrinol., Vol. 24, 574-4586, 2010.03.
47. Malchinkhuu E, Sato K, Maehama T, Ishiuchi S, Yoshimoto Y, Mogi C, Kimura T, Kurose H, Tomura H, Okajima F., Role of Rap1B and Tumor Suppressor PTEN in the Negative Regulation of Lysophosphatidic Acid-induced Migration by Isoproterenol in Glioma Cells., Mol Biol Cell., 20, Vol. 20, 5156-5165, 2009.12.
48. Malchinkhuu E, Sato K, Maehama T, Ishiuchi S, Yoshimoto Y, Mogi C, Kimura T, Kurose H, Tomura H, Okajima F., Role of Rap1B and Tumor Suppressor PTEN in the Negative Regulation of Lysophosphatidic Acid-induced Migration by Isoproterenol in Glioma Cells., Mol Biol Cell., 20, Vol. 20, 5156-5165, 2009.12.
49. Yano T, Itoh Y, Kawamura E, Maeda A, Egashira N, Nishida M, Kurose H, Oishi R., Amphotericin B-induced renal tubular cell injury is mediated by Na+ Influx through ion-permeable pores and subsequent activation of mitogen-activated protein kinases and elevation of intracellular Ca2+ concentration., Antimicrob Agents Chemother., 53, 1420-1426, 2009.03.
50. Shibata, T., Nakahara, H., Kita, N., matsubara, Y., Han, C., Morimitsu, Y., Iwamoto, N., Kumagai, Y., Nishida, M., Kurose, H., Aoki, N., Ojika, M., and Uchida, K., A food-derived synergist of NGF signaling: identification of protein tyrosine phosphatase 1B as a key regulator of NGF receptor-initiated signal transduction., J. Neurochem., 107 (5), 1248-1260, 2008.05.
51. Nishida, M., Sato, Y., Uemura, A., Narita, Y., Tozaki-Saitoh, H., Nakaya, M., Ide, T., Suzuki, K., Inoue, K., Nagao, T., and Kurose, H., P2Y6 receptor-G12/13 signaling in cardiomyocytes triggers pressure overload-induced cardiac fibrosis., EMBO J., 27 (23), 3104-3115, 2008.05.
52. Kiyonaka, S., Kato, K., Nishida, M., Mio, K., Numaga, T., Sawaguchi, Y., Yoshida, T., Wakamori, M., Mori, E., Numata, T., Ishii, M., Takemoto, H., Ojida, A., Watanabe, K., Uemura, A., Kurose, H., Morii, T., Kobayashi. T., Sato, Y., Sato, C., Hamachi, I., and Mori, Y., Selective and direct inhibition of TRPC3 channels underlies biological activities of a pyrazole compound., Proc. Natl. Acad. Sci. USA, 106 (13), 5400-5405, 2008.05.
53. Malchinkuhuu, E., Sato, K., Maehama, T., Mogi, C., Tonomura, H., Ishiuchi, S., Yoshimoto, Y., Kurose, H., and Okajima, F., S1P2 receptors mediate inhibition of glioma cell migration through Rho signakling pathways independent of PTEN., Biochem. Biophys. Res. Commun., 366 (4), 963-968, 2008.05.
54. Kimura, T., Mogi, C., Tomura, H., Kuwabara, A., Im, D.S., Sato, K., Kurose, H., Murakami, M., and Okajima, F., Induction of scavenger receptor class B type I is critical for simvastatin enhancement of high-density lipoprotein-induced anti-inflammatory actions in endothelial cells., J. Immunol. , 181 (10), 7332-73340, 2008.05.
55. Kusano, Y., Horie, S., Shibata, T., Satsu, H., Shimizu, M., Hitomi, E., Nishida, M., Kurose, H., Itoh, K., Kobayashi, A., Yamamoto, M., and Uchida, K., Keap1 regulates the constitutive expression of GST A1 during differentiation of Caco-2 cells., J. Neurochem., 107 (5), 1248-1260, 2008.05.
56. Obara, Y., Okano, Y., Ono, S., Yamauchi, A., Hoshino, T., Kurose, H., and Nakahata, N., bg subunits of Gi/o suppress EGF-induced ERK5 phosphorylation, whereas ERK1/2 phosphorylation is enhanced., Cell. Signal., 20, 1275-1283, 2008.05.
57. Urayama, K., Célia Guilini, C., Turkeri, G., Takir, S., Kurose, H., Messaddeq, N., Dierich, A., and Nebigil, C.G., Prokineticin Receptor-1 Induces Neovascularization and Epicardial-Derived Progenitor Cell Differentiation., Arterioscler Thromb Vasc Biol. , 28 (5), 841-849, 2008.05.
58. Cho, E.Y., Cho, D.I., Park, J.H., Kurose, H., Caron, M.G., and Kim, K.M., Roles of protein kinase C and actin-binding protein 280 in the regulation of intracellular trafficking of dopamine D3 receptor., Mol. Endcrinol., 21 (9), 2242-2254, 2007.08.
59. Nishida, M., Onohara, N., Sato, Y., Suda, R., Ogushi, M., Tanabe, S., Inoue, R., Mori, Y., and Kurose, H. , Gα12/13-mediated upregulation of TRPC6 negatively regulates endothelin-1-induced cardiac myofibroblast formation and collagen synthesis through NFAT activation., J. Biol. Chem., 282 (32), 23117-23128, 2007.07.
60. Urayama K, Guilini C, Messaddeq N, Hu K, Steenman M, Kurose H, Ert G, Nebigil CG., The prokineticin receptor-1 (GPR73) promotes cardiomyocyte survival and angiogenesis.
, FASEB J., 356(1), 279-285, 2007.04.
61. Hirai F, Nakayamada S, Okada Y, Saito K, Kurose H, Mogami A, Tanaka Y., Small GTPase Rho signaling is involved in beta1 integrin-mediated up-regulation of intercellular adhesion molecule 1 and receptor activator of nuclear factor kappaB ligand on osteoblasts and osteoclast maturation.
, Biochem. Biophys. Res. Commun., 356(1), 279-285, 2007.04.
62. Tobo M, Tomura H, Mogi C, Wang JQ, Liu JP, Komachi M, Damirin A, Kimura T, Murata N, Kurose H, Sato K, Okajima F., Previously postulated "ligand-independent" signaling of GPR4 is mediated through proton-sensing mechanisms.
, Cell Signal., in press, 2007.05.
63. Onohara N, Nishida M, Inoue R, Kobayashi H, Sumimoto H, Sato Y, Mori Y, Nagao T, and Kurose H, TRPC3 and TRPC6 are essential for angiotensin II-induced cardiac hypertrophy, EMBO J., 25, 5305-5316, 2006.11.
64. Mangmool, S., Haga, T., Kobayashi, H., Kim, K-M., Nakata, H., Nishida, M., and Kurose, H, Clathrin required for phosphorylation and internalization of β2-adrenergic receptor by G protein-coupled receptor kinase 2 (GRK2), J. Biol. Chem., 281, 31940-31949, 2006.10.
65. Kimura, T., Tomura, H., Mogi, C., Kuwabara, A., Ishiwara, M., Shibasawa, K., Sato, K., Ohwada, S., Im, D.S,, Kurose, H., Ishizuka, T., Murakami, M., and Okajima, F, Sphingosine 1-phosphate receptors mediate stimulatory and inhibitory signalings for expression of adhesion molecules in endothelial cells, Cell Signal., 18 (6), 841-850 (2006), 2006.06.
66. Malchinkhuu, E., Sato, K., Horiuchi, Y., Mogi, C., Ohwada, S., Ishiuchi, S., Saito, N., Kurose, H., Tomura, H., and Okajima, F, Role of p38 mitogen-activated kinase and c-Jun terminal kinase in migration response to lysophosphatidic and sphingosine 1-phosphate in glioma cells., Oncogene, 10.1038/sj.onc.1208805, 24, 44, 6676-6688, 24 (44), 6676-6688 (2005), 2005.10.
67. Maeda, S., Matsuoka, I., Iwamoto, T., Kurose, H., and Kimura, J., Down-regulation of Na+/Ca2+ exchanger by fluvastatin in rat cardiomyoblast H9c2 cells: Involvement of RhoB in Na+/Ca2+ exchanger mRNA stability., Mol. Pharmacol, 10.1124/mol.104.000786, 68, 2, 414-420, 68 (2), 414-420 (2005), 2005.08.
68. Obara, Y., Kurose, H., and Nakahata, N., Thronboxane A2 promotes interleukin-6 synthesis mediated by an activation of cyclic AMP-response element binding protein in 1321N1 human astrocytoma cells, Mol. Pharmacol., 68 (3), 670-679 (2005), 2005.09.
69. Mizuno, N., Kokubu, H., Sato, M., Nishimura, A., Yamauchi, J., Kurose, H., and Itoh, H, G protein-coupled receptor signaling through Gq and JNK negatively regulates neural progenitor cell migration, Proc. Natl. Acad. Sci. USA, 10.1073/pnas.0506101102, 102, 35, 12365-12370, 102 (35), 12365-12370 (2005), 2005.08.
70. Fukutomi, M., Nishida, M., Maruyama, Y., Kobayashi, H., and Kurose, H., Caveolae-independent activation of protein kinase A in rat neonatal myocytes., J. Pharmacol. Sci., 10.1254/jphs.FP0050244, 98, 2, 168-174, .98 (2), 168-174, 2005.06.
71. Nishida, M., Tanabe, S., Maruyama, Y., Nagamatsu, Y., Takagahara, S., Turner, J. H., Kozasa, T., Kobayashi, H., Sato, Y., Kawanishi, T., Inoue, R., Nagao, T., and Kurose, H., Gα12/13- and reactive oxygen species-dependent activation of c-Jun NH2-terminal kinase and p38 MAPK by angiotensin II receptor stimulation in rat neonatal cardiomyocytes, J. Biol. Chem., 10.1074/jbc.M409710200, 280, 18, 18434-18441, 280 (18), 18434-18441, 2005.05.
72. Fujii, T., Onohara, N., Maruyama, Y., Tanabe, S., Kobayashi, H., Fukutomi, M., Nagamatsu, Y., Nishihara, N., Inoue, R., Sumimoto, H., Shibasaki, F., Nagao, T., Nishida, M., and Kurose, H, Gα12/13-mediated production of reactive oxygen species is critical for angiotensin receptor-induced NFAT activation in cardiac fibroblasts., J. Biol. Chem., 10.1074/jcb.M409397200, 280, 24, 23041-23047, 280 (24), 23041-23047 (2005), 2005.06.
73. Kawata,T., Ishizuka, T., Tomura, H., Takeshi Hisada, T., Dobashi, K., Tsukagoshi, H., Ishiwara, M., Kurose, H., Mori, M., and Okajima, F, Sphingosine 1-phosphate inhibits migration and RANTES production in human bronchial smooth muscle cells., Biochem. Biophys. Res. Commun., 10.1016/j.bbrc.2005.03.223, 331, 2, 640-647, Biochem. Biophys. Res. Commun., 2005.06.
74. Nakayamada, S., Kurose, H., Saito, K., Mogami, A., and Tanaka, Y, Small GTP-binding Protein Rho-mediated Signaling Promotes Proliferation of Rheumatoid Synovial Fibroblasts., Arthritis Res. Ther., 10.1186/ar1694, 7, 3, R476-R484, 7, R476-R484, 2005.02.
75. Kobayashi, H., Narita, Y., Nishida, M., and Kurose, H, β-Arrestin2 enhances β2-adrenergic receptor-mediated nuclear translocation of extracellular signal-regulated kinase., Cellular Signaling, 10.1016/j.cellsig.2004.12.014, 17, 10, 1248-1253, 17(10), 1248-1253 (2005), 2005.10.
76. Wang, J-Q., Kon, J., Mogi, C., Tobo, M., Damirin, A., Sato, K., Komachi, M., Malchinkhuu, E., Murata, N., Kimura, T., Kuwabara, A., Wakamatsu, K., Koizumi, H., Uede, T., Tsujimoto, G., Kurose, H., Sato, T., Harada, A., Misawa, N., Tomura, H., and Okajima,, TDAG8 is a proton-sensing and psychosine-sensitive G-protein-coupled receptor., J. Biol. Chem., 10.1074/jbc.M406966200, 279, 44, 45626-45633, 279 (44), 45626-45633, 2004.10.
77. Saito, Y., Tetsuka, M., Li, Y., Kurose, H., and Maruyama, K, Properties of rat melanin-concentrating hormone receptor 1 internalization., Peptides, 10.1016/j.peptides.2004.03.026, 25, 10, 1597-1604, 25 (10), 1597-1604, 2004.10.
78. Arai, K., Lee, S. R., van Leyen, K., Kurose, H., and Lo, E. H, Involvement of ERK MAP kinase in endoplasmic reticulum stress in SH-SY5Y human neuroblastoma cells., J. Neurochem., 10.1111/j.1471-4159.2004.02317.x, 89, 1, 232-239, 89 (1), 232-239, 2004.04.
79. Tashiro, K., Nagao, T., Kurose, H., Ichijo, H., and Urushidani, T, Role of Rho in rabbit parietal cell., J. Cell. Physiol., 10.1002/jcp.10370, 197, 3, 409-417, 197 (3), 409-417, 2003.12.
80. Ahmed, M., Hanaoka, Y., Nagatomo, T., Kiso, T., Kaita, T., Kurose, H., and Nagao, T, Binding and functional affinity of some newly synthesized phenethylamine and phenoxypropanolamine derivatives for their agonistic activity at recombinant human β3-adrenoceptor, J. Pharm. Pharmacol., 55, 95-101, 2003.01.
81. Arai, K., Maruyama, Y., Nishida, Tanabe, S., Takagahara, S., Turner, J. H., Kozasa, T., Mori, Y., Nagao, T., and Kurose, H., Differential requirement of Gα12, Gα13, Gαq and Gβγ for endothelin-1-induced JNK and ERK activation., Mol. Pharmacol., 10.1124/mol.63.3.478, 63, 3, 478-488, 63, 478-488, 2003.03.
82. Maruyama, Y., Nishida, M., Sugimoto, Y., Tanabe, S., Turner, J. H., Kozasa, T., Wada, T., Nagao, T., and Kurose, H., Gα12/13 Mediate α1-Adrenergic Receptor-induced Cardiac Hypertrophy., Circ. Res., 10.1161/01.RES.0000043282.39776.7C, 91, 10, 961-969, 91, 961-969, 2002.11.
83. Sugimoto, Y., Fujisawa, R., Tanimura, R., Lattion, A. L., Cotecchia, S., Tujimoto, G., Nagao, T., and Kurose, H, β1-Selective agonist (-)-1-(3, 4-dimethoxyphenetylamino)-3-(3, 4-dihydroxy)-2-propanol [(-)-RO363] differentially interacts with key amino acids responsible for β1-selective binding in resting and active states., J. Pharmacol. Exp. Ther., 301, 51-58, 2002.04.
84. Isogaya. M., Nagao, T., and Kurose, H, Enhanced cAMP response of the naturally occurring mutant of human β3-adrenoceptor., Jpn. J. Pharamcol., 88, 314-318, 2002.03.
85. Endo, A., Nagashima, K., Kurose, H., Mochizuki, S., Matsuda, M., and Mochizuki, N, Sphingosine 1-phosphate induces membrane ruffling and increases motility of human umbilical vein endothelial cells via vascular endothelial growth factor receptor and CrkII., J. Biol. Chem., 277, 23747-23754, 2002.06.
86. Nishida, M., Takagahara, S., Maruyama, Y., Sugimoto, Y., Nagao, T., and Kurose, H., Gβγ counteracts Gαq signaling upon α1-adrenergic receptor stimulation., Biochem,. Biophys. Res. Commun., 291, 995-1000, 2002.03.
87. Nishida, M., Schey, K., Takagahara, S., Kontani, K., Katada, T., Urano, Y., Nagano, T., Nagao, T., and Kurose, H, Activation mechanism of Gi and Go by reactive oxygen species., J. Biol. Chem., 277, 9036-9042, 2002.03.
88. Hara, Y., Wakamori, M., Ishii, M., Maeno, E., Nishida, M., Yoshida, T., Yamada, H., Shimizu, S., Mori, E., Kudoh, J., Shimizu, N., Kurose, H., Okada, Y., Imoto, K., Mori, Y., LTRPC2 Ca2+-permeable channel activated by changes in redox status confers susceptibility to cell death., Mol. Cell, 9, 163-172, 2002.01.
89. Shiina, T., Arai, K., Tanabe, S., Yoshida, N., Haga, T., Nagao, T., and Kurose, H., Clathrin box in G protein-coupled receptor kinase 2., J Biol Chem., 276, 33019-33026, 2001.08.
90. Shiina, T., Nagao, T., and Kurose, H.:, Low affinity of β1-adrenergic receptor for β-arrestins explains the resistance to agonist-induced internalization., Life Sci., 68, 2251-2257, 2001.04.
91. Nishida, M., Maruyama, Y., Tanaka, R., Kontani, K., Nagao, T., and Kurose, H., Giα and Goα are target proteins of reactive oxygen species., Nature, 408, 492-495, 2000.11.
92. Shiina, T., Kawasaki, A., Nagao, T., and Kurose, H, Interaction with β-arrestin determines the difference in internalization behavior between β1- and β2-adrenergic receptors., J. Biol. Chem., 275, 29082-29090, 2000.09.
93. Nakamura, T., Suzuki, A., Ohnuki, T., Hattori, K., Watanabe, K., Kurose, H., Nagao, T., and Nagatomo, T, Assessment of affinities of propranolol and bopindolol to membranes from COS-7 cell transiently transfected with β1- and β2-adrenoceptors using a radioligand binding assay method., Pharmacology, 61, 6-10, 2000.07.
94. Isogaya, M., Sugimoto, Y., Tanimura, R., Tanaka, R., Kikkawa, H., Nagao, T., and Kurose, H., Binding pockets of the β1- and β2-adrenergic receptors for subtype selective agonists., Mol. Pharmacol., 56, 875-885, 1999.11.
95. Takesono, A., Zahner, J., Blumer, K. J., Nagao, T., and Kurose, H., Negative regulation of α2-adrenergic receptor-mediated Gi signaling by a novel pathway., Biochem. J., 343 (1), 77-85, 1999.10.
96. Nishida, M., Nagao, T., and Kurose, H, Activation of Rac1 increases c-Jun NH2-terminal kinase activity and DNA fragmentation in a calcium-dependent manner in rat myoblast cell line H9c2., Biochem. Biophys. Res. Commun., 262, 350-354, 1999.08.
97. Sato, T., Nagao, T., and Kurose, H., Ser203 as well as Ser204 and Ser207 in fifth transmembrane domain of the human β2-adrenoceptor contributes to agonist binding and receptor activation., Br. J. Pharmacol., 128, 272-274, 1999.09.
98. Akiyama, C., Nagao, T., and Kurose, H., Analysis of domain responsible for desensitization of β1-adrenergic receptor., Jpn. J. Pharmacol., 81 (1), 12-20, 1999.09.

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