Kyushu University Academic Staff Educational and Research Activities Database
List of Reports
Mitsuhiro Furuse Last modified date:2021.06.15

Professor / Animal and Marine Bioresource Sciences / Department of Bioresource Sciences / Faculty of Agriculture

1. Phuong V. Tran, Vishwajit S. Chowdhury, Mitsuhiro Furuse, Central regulation of feeding behavior through neuropeptides and amino acids in neonatal chicks, Amino Acids, 10.1007/s00726-019-02762-x, 2019.08, Animals at the neonatal stage have to eat more to support better growth and health. However, it is difficult to understand the mechanism of feeding during an early stage of life in the brain of the rodent model. Chickens are precocial and they can look for their food by themselves right after hatching. Neonatal chicks have a relatively large-sized brain; therefore, the drugs are easy to administer centrally and changes in food intake can be clearly monitored. Sleeping status, which affects food intake, can be estimated from the posture. The closest vertebrate outgroup to mammals is birds, but it was reported that the organization of the human genome is closer to that of the chicken than the mouse. Thus, it is important to understand the central mechanism of feeding regulation in the neonatal chicks. In neuropeptides, the number of candidates as the orexigenic factor was less than those as the anorexigenic factor, even at an early growth stage. Some of the neuropeptides have reverse effects, e.g., ghrelin and prolactin releasing peptides, or no effects compared to the effects confirmed in mammals. Some of the genetic differences between meat-type (broiler) and layer-type chickens would explain the difference in food intake. On the other hand, it was difficult to explain the feeding mechanism by neuropeptides alone, as neonatal chicks have a repeated feeding, sleeping, and resting behavior within a short period. Some of the amino acids and their metabolites act centrally to regulate feeding with sedative and hypnotic effects. In conclusion, endogenous neuropeptides and endogenous and/or exogenous nutrients like amino acids collaborate to regulate feeding behavior in neonatal chicks..
2. Shozo Tomonaga, Mitsuhiro Furuse, Nutritional characteristics and functions of D-amino acids in the chicken, Journal of Poultry Science, 10.2141/jpsa.0190062, 2020.01, D-Amino acids occur in modest amounts in bacterial proteins and the bacterial cell wall, as well as in peptide antibiotics. Therefore, D-amino acids present in terrestrial vertebrates were believed to be derived from bacteria present in the gastrointestinal tract or fermented food. However, both exogenous and endogenous origins of D-amino acids have been confirmed. Terrestrial vertebrates possess an enzyme for converting certain L-isomers to D-isomers. D-Amino acids have nutritional aspects and functions, some are similar to, and others are different from those of L-isomers. Here, we describe the nutritional characteristics and functions of D-amino acids and also discuss the future perspectives of D-amino acid nutrition in the chicken..
3. #Han, G., #Yang, H., @Tashiro, K., Bungo, T., @Furuse, M. and @Chowdhury, V.S., In ovo administration of L-leucine: a novel approach to affording thermotolerance in broiler chicks., Proceedings of Japanese Society for Animal Nutrition and Metabolism, 63 (1):1-14., 2019.03.
4. Chowdhury, V.S., Han, G., Yang, H., Ikeda, H., Bungo, T. and Furuse, M., L-Citrulline and L-leucine-mediated thermoregulation affords thermotolerance, Proceedings of Japanese Society for Animal Nutrition and Metabolism, 61 (2):1-11, 2017.10.
5. Tatsumi, R., Suzuki, T., Ohya, Y., Do, Mai-Khoi Q., Ohtsubo, H., Kawaguchi, M., Anderson, J.E., Mizunoya, W., Komiya, Y., Qahar, M., Ojima, K., Sawano, S., Nakamura, M., Furuse, M., Ikeuchi, Y., and Allen, R.E., Experiments reveal a novel mechanism to regulate myofiber types and its activation by functional food ingredient, Proceedings of Japanese Society for Animal Nutrition and Metabolism, 60 (2):69-77, 2016.10.
6. Furuse, M., Screening of central functions of amino acids and their metabolites for sedative and hypnotic effects using chick model, European Journal of Pharmacology, 2015.09.
7. 濱洲紘介・古瀬充宏, L-プロリン,D-プロリンの催眠作用とNMDA受容体,グリシン受容体, 生体の科学, 60(5):366-367, 2009.10.
8. Kaiya, H., Furuse, M. , Miyazato, M. and Kangawa, K., Current knowledge about the roles of ghrelin in regulating food intake and energy balance in birds, General and Comparative Endocrinology, 163(1-2):33-38, 2009.09.
9. Yamane, H., Denbow, D.M. and Furuse, M., Screening dipeptides having central functions for excitation and sedation, Mini-Reviews in Medicinal Chemistry, 9(3):300-305, 2009.03.
10. Yamane, H., Kurauchi, I., Denbow, D.M. and Furuse, M., Central functions of nutrients for the stress response in chicks, Asian-Australasian Journal of Animal Science, 22(2):296-304, 2009.02.
11. Yamane, H., Denbow, D.M. and Furuse, M., Regulation of stress responses by peptides and small nitrogenous compounds in neonatal chicks, Avian and Poultry Biology Reviews, 18 (4): 107–122, 2007.12.
12. Furuse, M., Yamane, H., Tomonaga, S., Tsuneyoshi, Y. and Denbow, D.M., Neuropeptidergic Regulation of Food Intake in the Neonatal Chick: A Review, Journal of Poultry Science, 44(4):349-356, 2007.11.
13. Furuse, M., Behavioral regulators in the brain of neonatal chicks, Animal Science Journal, 78(3):218-232, 2007.06.
14. Furuse, M., Central regulation of food intake in the neonatal chick, Animal Science Journal, 73(2):83-94, 2002.01.
15. Furuse, M., Release and endogenous actions of the gastrin/cholecystokinin (CCK) family in the chicken, Journal of Experimental Zoology, 283(4-5):448-454, 1999.01.