| 1. |
Kunio Ishikawa, Tya Indah Arifta, Koichiro Hayashi, Kanji Tsuru, Fabrication and evaluation of interconnected porous carbonate apatite from alpha tricalcium phosphate spheres, Journal of Biomedical Materials Research - Part B Applied Biomaterials, 10.1002/jbm.b.34117, Vol.107, No.2, pp.269-277, 2021.02, Carbonate apatite (CO 3 Ap) blocks have attracted considerable attention as an artificial bone substitute material because CO 3 Ap is a component of and shares properties with bone, including high osteoconductivity and replacement by bone similar to autografts. In this study, we fabricated an interconnected porous CO 3 Ap block using α-tricalcium phosphate (TCP) spheres and evaluated the tissue response to this material in a rabbit tibial bone defect model. Interconnected porous α-TCP, the precursor of interconnected porous CO 3 Ap, could not be fabricated directly by sintering α-TCP spheres. It was therefore made via a setting reaction with α-TCP spheres, yielding interconnected porous calcium-deficient hydroxyapatite that was subjected to heat treatment. Immersing the interconnected porous α-TCP in Na–CO 3 –PO 4 solution produced CO 3 Ap, which retained the interconnected porous structure after the dissolution–precipitation reaction. The diametral tensile strength and porosity of the porous CO 3 Ap were 1.8 ± 0.4 MPa and 55% ± 3.2%, respectively. Both porous and dense (control) CO 3 Ap showed excellent tissue response and good osteoconductivity. At 4 weeks after surgery, approximately 15% ± 4.9% of the tibial bone defect was filled with new bone when reconstruction was performed using porous CO 3 Ap; this amount was five times greater than that obtained with dense CO 3 Ap. At 12 weeks after surgery, for porous CO 3 Ap, approximately 47% of the defect was filled with new bone as compared to 16% for dense CO 3 Ap. Thus, the interconnected porous CO 3 Ap block is a promising artificial bone substitute material for the treatment of bone defects caused by large fractures or bone tumor resection. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 107B: 269–277, 2019.. |
| 2. |
Surface functionalization with copper endows carbonate apatite honeycomb scaffold with antibacterial, proangiogenic, and pro-osteogenic activities. |
| 3. |
Koichiro Hayashi, Masaya Shimabukuro, Ryo Kishida, Akira Tsuchiya, Kunio Ishikawa, Structurally optimized honeycomb scaffolds with outstanding ability for vertical bone augmentation, Journal of Advanced Research, 10.1016/j.jare.2021.12.010, Vol.41, pp.101-112, 2022.11. |
| 4. |
Masaya Shimabukuro, Koichiro Hayashi, Ryo Kishida, Akira Tsuchiya, Kunio Ishikawa, No-Observed-Effect Level of Silver Phosphate in Carbonate Apatite Artificial Bone on Initial Bone Regeneration, ACS Infectious Diseases, 10.1021/acsinfecdis.1c00480, Vol.8, No.1, pp.159-169, 2022.01. |
| 5. |
Koichiro Hayashi, Toshiki Yanagisawa, Masaya Shimabukuro, Ryo Kishida, Kunio Ishikawa, Granular honeycomb scaffolds composed of carbonate apatite for simultaneous intra- and inter-granular osteogenesis and angiogenesis, Materials Today Bio, 10.1016/j.mtbio.2022.100247, Vol.14, p.100247, 2022.03. |
| 6. |
Fabrication of vaterite blocks from a calcium hydroxide compact. |
| 7. |
Pery Freitas, Ryo Kishida, Koichiro Hayashi, Akira Tsuchiya, Masaya Shimabukuro, Kunio Ishikawa, Fabrication and histological evaluation of porous carbonate apatite blocks using disodium hydrogen phosphate crystals as a porogen and phosphatization accelerator, Journal of Biomedical Materials Research Part A, 10.1002/jbm.a.37374, Vol.110, pp.1278-1290, 2022.02. |
| 8. |
Wee-Keat Cheah, Kunio Ishikawa, Radzali Othman, Fei-Yee Yeoh, Nanoporous biomaterials for uremic toxin adsorption in artificial kidney systems: A review. , Journal of Biomedical Materials Research Part B: Applied Biomaterials, 105B, 1232-1240, 2016.02. |
| 9. |
Kunio Ishikawa, Aivaras Kareiva, Sol-gel synthesis of calcium phosphate-based biomaterials - A review., CHEMIJA, Vol. 31. No. 1. P. 25–41, 2020.02. |
| 10. |
Kunio Ishikawa, Edita Garskaite, Aivaras Kareiva, Sol–gel synthesis of calcium phosphate-based biomaterials—A review of environmentally benign, simple, and effective synthesis routes., Journal of Sol-Gel Science and Technology , volume 94, pages551–572(2020), 2020.02. |
| 11. |
Kunio Ishikawa, Carbonate apatite bone replacement: Learn from the bone., Journal of the Ceramic Society of Japan, doi:10.2109/jcersj2.19042, 127 巻 9 号 p. 595-601, 2019.09. |
| 12. |
Toshiki Miyazaki, Ishikawa Kunio, Yuki Shirosaki, Chikara Ohtsuki, Organic-Inorganic composites designed for biomedical application. , 2013.11. |
| 13. |
Kien-Seng Lew,, Radzali Othman, Ishikawa Kunio, Fei-Yee Yeoh, Macroporous bioceramics: A remarkable material for bone regeneration. , Journal of Biomaterials Applications,, 2012.09. |
| 14. |
Kien-Seng Lew, Radzali Othman, Ishikawa Kunio, Fei-Yee Yeoh, Macroporous bioceramics: a remarkable material for bone regeneration., 2011.08. |
| 15. |
Ishikawa Kunio, Bone substitute fabrication based on dissolution-precipitation reaction. , Materials, 2010.02. |
