Kyushu University Academic Staff Educational and Research Activities Database
List of Books
Yusaku Nakabeppu Last modified date:2021.12.09

Professor / Division of Neurofunctional Genoimics / Department of Immunobiology and Neuroscience / Medical Institute of Bioregulation

1. Nakabeppu, Y., Ninomiya, T, Diabetes Mellitus, A risk factor for Alzheimer's Disease, Springer Nature,, 2019.05, This book describes the precise mechanisms by which insulin resistance and diabetes mellitus (DM) act as risk factors for Alzheimer’s disease (AD). It opens by discussing the de novo synthesis of insulin in the brain and its functional significance with regard to glucose metabolism and maintenance of neuronal function in the brain. The epidemiological evidence that DM is a risk factor for the development of dementia, including AD as well as vascular dementia, is then examined. Subsequent chapters explore in depth the mechanisms involved in this relationship, including abnormal protein processing, dysregulated glucose metabolism, impaired insulin signaling, and mitochondrial dysfunction. The molecular interactions between diabetes and AD are fully discussed, highlighting the pathological molecular mechanisms induced by diabetes that promote and accelerate AD pathology. Finally, diagnostic biomarkers and potential therapeutic approaches for AD are considered on the basis of the presented evidence. In providing answers to the critical questions of whether and why DM is a risk factor for AD, this book will hold appeal for a wide interdisciplinary audience..
2. Nakabeppu, Y., Origins of Brain Insulin and Its Function. In: Diabetes Mellitus, A rist factor for Alzheimmer’s disease., Springer Nature, 10.1007/978-981-13-3540-2_1, Chapter 1, pp. 1-11., 2019.05.
3. Nakabeppu, Y., Molecular Pathophysiology of Insulin Depletion, Mitochondrial Dysfunction, and Oxidative Stress in Alzheimer's Disease Brain. In: Diabetes Mellitus, A rist factor for Alzheimmer’s disease., Springer Nature, 10.1007/978-981-13-3540-2_3, Chapter 3, pp. 27-44., 2019.05.
4. Nakabeppu Y, Neurodegeneration caused by accumulation of an oxidized base lesion, 8-oxoguanine, in nuclear and mitochondrial DNA: from animal models to human diseases, in The Base Excision Repair Pathway – Molecular Mechanisms and Role in Disease Development and Therapeutic Design–, edited by David M Wilson III., World Scientific, 10.1142/9789814719735_0015, Chapter 14, pp.523-556
978-981-4719-73-5, 2017.02.
5. Sango K, Niimi N, Tsukamoto M, Utsunomiya K, Sakumi K, Nakabeppu Y, Kadoya T, Horie H, What have we learn from cultured adult dorsal root ganglion neurons, in Ganglion Cells: Morphology, Functional Development and Role in Disease, L.G. Vlastimil, Editor, Nova Science Publishers, Inc. Hauppauge, NY USA, p125-148, 2014.04.
6. Ohno, M., Oka, S., and Nakabeppu, Y. , Quantitative analysis of oxidized guanine, 8-oxoguanine, in mitochondrial DNA by immunofluorescence method. In Mitochondrial DNA, Methods and Protocols, (J.A. Stuart, ed.), Humana Press, New York, Methods Mol Biol 544: 199-212, 2009.07.
7. Oka, S., Ohno, M., and Nakabeppu, Y., Construction and characterization of a cell line deficient in repair of mitochondrial, but not nuclear, oxidative DNA damage. In Mitochondrial DNA, Methods and Protocols, (J.A. Stuart, ed.), Humana Press, New York, Methods Mol Biol 544: 251-264., 2009.07.
8. Nakabeppu, Y., Behmanesh, M., Yamaguchi, H., Yoshimura, D., and Sakumi, K., Prevention of the mutagenecity and cytotoxicity of oxidized purine nucleotides, In Oxidative Damage to Nucleic Acids, (M. D. Evans, and M. S. Cooke, eds. ), Molecular Biology Intelligence Unit. Springer, New York, NY, USA, Chapter 3, p40-53., 2007.07.
9. Nakabeppu, Y, et al., Genomics and Genetics: From Molecular Details to Analysis and Techniques (Meyers, R.A. ed.), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany., DNA Replication and Transcription:
Vol. 1: pp. 47-73, 2007.02.