Kyushu University Academic Staff Educational and Research Activities Database
List of Reports
Yusaku Nakabeppu Last modified date:2021.12.09

Professor / Division of Neurofunctional Genoimics / Department of Immunobiology and Neuroscience / Medical Institute of Bioregulation

1. Understanding Alzheimer’s disease as brain diabetes.
2. Murakami, Y., Nakabeppu, Y., Sonoda, K., Oxidative Stress and Microglial Response in Retinitis Pigmentosa., International Journal of Molecular Sciences, 10.3390/ijms21197170, 2020.09.
3. Yusaku Nakabeppu, Eiko Ohta, Nona Abolhassani, MTH1 as a nucleotide pool sanitizing enzyme: friend or foe?, Radic Biol Med, 107, 151-158., doi: 10.1016/j.freeradbiomed.2016.11.002., 2017.06.
4. Arikuni Uchimura, Yuichiro Hara, Yoichi Gondo, Yusaku Nakabeppu, International Symposium on “Germline Mutagenesis and Biodiversification”, Genes Genet. Syst., Genes Genet Syst. 2014;89(2):93-95., 2014.09.
5. Yusaku Nakabeppu, Cellular Levels of 8-Oxoguanine in either DNA or the Nucleotide Pool Play Pivotal Roles in Carcinogenesis and Survival of Cancer Cells, Int J Mol Sci. 2014, 15(7):12543-12557. doi: 10.3390/ijms150712543., 2014.07, [URL], 8-Oxoguanine, a major oxidized base lesion formed by reactive oxygen species, causes G to T transversion mutations or leads to cell death in mammals if it accumulates in DNA. 8-Oxoguanine can originate as 8-oxo-dGTP, formed in the nucleotide pool, or by direct oxidation of the DNA guanine base. MTH1, also known as NUDT1, with 8-oxo-dGTP hydrolyzing activity, 8-oxoguanine DNA glycosylase (OGG1) an 8-oxoG DNA glycosylase, and MutY homolog (MUTYH) with adenine DNA glycosylase activity, minimize the accumulation of 8-oxoG in DNA; deficiencies in these enzymes increase spontaneous and induced tumorigenesis susceptibility. However, different tissue types have different tumorigenesis susceptibilities. These can be reversed by combined deficiencies in the defense systems, because cell death induced by accumulation of 8-oxoG in DNA is dependent on MUTYH, which can be suppressed by MTH1 and OGG1. In cancer cells encountering high oxidative stress levels, a high level of 8-oxo-dGTP accumulates in the nucleotide pool, and cells therefore express increased levels of MTH1 in order to eliminate 8-oxo-dGTP. Suppression of MTH1 may be an efficient strategy for killing cancer cells; however, because MTH1 and OGG1 protect normal tissues from oxidative-stress-induced cell death, it is important that MTH1 inhibition does not increase the risk of healthy tissue degeneration. .
6. Fujita K, Yamafuji M., Yusaku Nakabeppu, MAMI NODA, Therapeutic approach to neurodegenerative diseases by medical gases: focusing on redox signaling and related antioxidant enzymes, Oxid Med Cell Longev. 2012:324256. , doi: 10.1155/2012/324256. , 2012.07.
7. 作見 邦彦, 土本 大介, 中別府 雄作, ニトロソ化ストレスによるイノシン三リン酸の生成と細胞応答, 細胞工学 Vol. 31: 175-180, 2012.01.
8. Kyota Fujita, Yusaku Nakabeppu, and Mami Noda, Therapeutic Effects of Hydrogen in Animal Models of Parkinson’s Disease, Parkinsons Dis. 2011:307875, 2011.04.
9. Oka S, Nakabeppu Y., DNA glycosylase encoded by MUTYH functions as a molecular switch for programmed cell death under oxidative stress to suppress tumorigenesis, Cancer Sci. 2011;102(4):677-682. , 2011.04.
10. Tsuzuki T, Piao JS, Isoda T, Sakumi K, Nakabeppu Y, Nakatsu Y, Oxidative stress-induced tumorigenesis in the small intestines of DNA repair-deficient mice, Health physics 100: 293-294, 2011.03.
11. Ihara H, Sawa T, Nakabeppu Y, Akaike T., Nucleotides function as endogenous chemical sensors for oxidative stress signaling, J Clin Biochem Nutr. 2011;48(1):33-39, 2011.01.
12. Sakumi K., Abolhassani N., Behmanesh M., Iyama T., Tsuchimoto D., Nakabeppu Y., ITPA protein, an enzyme that eliminates deaminated purine nucleoside triphosphates in cells., Mutation Research, 2010.06.
13. Tsuchimoto D., Iyama T., Nonaka M., Abolhassani N., Ohta E., Sakumi K., Nakabeppu Y., A comprehensive screening system for damaged nucleotide-binding proteins., Mutation Research, 2010.06.
14. Nakabeppu Y., Oka S., Sheng Z., Tsuchimoto D., Sakumi K. , Programmed cell death triggered by nucleotide pool damage and its prevention by MutT homolog-1 (MTH1) with oxidized purine nucleoside triphosphatase. , Mutation Research, 2010.06.
15. Yusaku Nakabeppu, Daisuke Tsuchimoto, Hiroo Yamaguchi and Kunihiko Sakumi, Oxidative Damage in Nucleic Acids and Parkinson's Disease, Journal of Neuroscience Research, 85(5):919-934. , 2007.04.
16. Teruhisa Tsuzuki, Yoshimichi Nakatsu and Yusaku Nakabeppu, Significance of error-avoiding mechanisms for oxidative DNA damage in carcinogenesis, Cancer Science, 98(4):465-470. , 2007.04.
17. Oxidative damage in genome by reactive oxygen species and diversity of human geneome.
18. Yusaku Nakabeppua, Kosuke Kajitani, Katsumi Sakamoto, Hiroo Yamaguchi, Daisuke Tsuchimoto, MTH1, an oxidized purine nucleoside triphosphatase, prevents the cytotoxicity and neurotoxicity of oxidized purine nucleotides, DNA Repair, Vol. 5(7): 761-772, 2006.07.
19. Nakabeppu Y., Sakumi K., Sakamoto K., Tsuchimoto D., Tsuzuki T., Nakatsu Y., Mutagenesis and carcinogenesis caused by the oxidation of nucleic acids., Biol. Chem., Vol. 387: 373-379., 2006.04.
20. Miura, T., Ohnishi, Y., Kurushima, H., Horie, H., Kadoya, T., and Nakabeppu, Y., Regulation of the Neuronal Fate by delta-FosB and its Downstream Target, Galectin-1., Current Drug Targets, 6:437-444, 2005.06.
21. Nakabeppu Y., Tsuchimoto D., Furuichi M., Sakumi K., The Defense Mechanisms in Mammalian Cells Against Oxidative Damage in Nucleic Acids and Their Involvement in the Suppression of Mutagenesis and Cell Death. , Free Radic Res, 38(5), 423-429, 2004.05.
22. Nakabeppu, Y., D. Tsuchimoto, A. Ichinoe, M. Ohno, Y. Ide, S. Hirano, D. Yoshimura, Y. Tominaga, M. Furuichi, and K. Sakumi., Biological Significance of the Defense Mechanisms against Oxidative Damage in Nucleic Acids Caused by Reactive Oxygen Species: from Mitochondria to Nuclei., Ann. NY Acad. Sci., Vol. 1011: 101-111., 2004.04.
23. Ishino Y, Nakabeppu Y, Maki H, Iwasaki H, Araki H, Shinagawa H., The 4(th) International Symposium on 3R; DNA Replication, Recombination and Repair., Genes Genet Syst., 79(1):53-63, 2004.02.
24. Nakabeppu, Y., Y. Tominaga, D. Tsuchimoto, Y. Ide, S. Hirano, Y. Sakai, K. Sakumi, and M. Furuichi., Mechanisms Protecting Genomic Integrity from Damage Caused by Reactive Oxygen Species: Implications for Carcinogenesis and Neurodegeneration., Environ. Mutagen. Res., Vol. 23:197-209, 2001.12.
25. Nakabeppu, Y., Regulation of intracellular localization of human MTH1, OGG1, and MYH proteins for repair of oxidative DNA damage., Prog. Nucleic Acid Res. Mol. Biol., Vol. 68:75-94., 2001.09.
26. Nakabeppu, Y., Molecular genetics and structural biology of human MutT homolog, MTH1., Mutat. Res., Vol. 477:59-70., 2001.06.