Kyushu University Academic Staff Educational and Research Activities Database
List of Reports
Yoshinao Oda Last modified date:2020.10.01

Professor / Department of Anatomic Pathology / Department of Basic Medicine / Faculty of Medical Sciences


Reports
1. Narazaki T, Shiratsuchi M, Matsushima T, Tsuda M, Tsukamoto Y, Muta H, Masuda T, Kimura D, Takamatsu A, Yamamoto H, Oda Y, Miyoshi H, Ohshima K, Matsuda Y, Sakamoto R, Nakashima Y, Ogawa Y. , Clinico-pathological Characteristics of Primary Adrenal Lymphomas - Potential Efficacy of Autologous Stem Cell Transplantation. , Leuk Lymphoma. 1-3 , 2020.02.
2. Kiyota M, Oya M, Ayano M, Niiro H, Iwasaki T, Fujiwara M, Oda Y, Fujimoto K, Ida H. , First case of pyrin-associated autoinflammation with neutrophilic dermatosis complicated by amyloidosis. , Rheumatology (Oxford)., PMID: 31998953 doi:10.1093/rheumatology/keaa005, 2020.01.
3. Yamamoto H, Ishihara S, Toda Y, Oda Y. , Histone H3.3 mutation in giant cell tumor of bone: an update in pathology. , Med Mol Morphol. , 53(1):1-6, 2020.03.
4. Abe C, Mori T, Yamada Y, Oda Y. , Lymphangioma, Soft Tissue. , Encyclopedia of Pathology. , https://doi.org/10.1007/978-3-319-28845-1_5487-1, 2019.11.
5. Mori T, Yamada Y, Hisaoka M ,Oda Y. , Intranodal Palisaded Myofibroblastoma. , Encyclopedia of Pathology., https://doi.org/10.1007/978-3-319-28845-1_5429-1, 2019.11.
6. Mori T, Yamada Y, Oda Y. , Calcifying Aponeurotic Fibroma.  , Encyclopedia of Pathology. , https://doi.org/10.1007/978-3-319-28845-1_5358-1, 2019.11.
7. Kyohei Yugawa, Kenichi Kohashi, Shinji Itoh, Tomoharu Yoshizumi, Ichiro Sakamoto, Hiroyuki Tsutsui, Masaki Mori, Yoshinao Oda, Combined hepatocellular-cholangiocarcinoma after tetralogy of Fallot repair
a case report and review of literature
, Pathology Research and Practice, 10.1016/j.prp.2020.152908, 2020.05, Background: Liver fibrosis and cancer are serious hepatic complications for patients with congenital heart diseases. We present a rare case of combined hepatocellular carcinoma (HCC) and cholangiocarcinoma (CCA) (cHCC-CCA) after the repair of tetralogy of Fallot (TOF). Case presentation: A 54-year-old Japanese woman had undergone biventricular repair for TOF at 7 years old. She presented with abdominal distension. Abdominal CT revealed ascites and a 90-mm tumor involving the liver's left lobe. Tumor marker values were: alpha-fetoprotein, 16,208 ng/mL and des-gamma-carboxy prothrombin, 33,920 mAU/mL. The preoperative diagnosis was malignant tumor of the liver (e.g., HCC or intrahepatic CCA). We performed a left lobectomy of the liver. Histopathologically, the tumor was composed of two components growing in trabecular and irregular tubular patterns accompanied by a transitional area; the tumor was diagnosed as cHCC-CCA. The non-cancerous area showed fibrous change mainly surrounding a central vein and sinusoid, expanding toward the portal area without inflammation. Conclusions: We provide the details of our patient's cHCC-CCA that developed from fibrous congestive liver associated with right-sided heart failure after TOF repair, diagnosed based on histopathological features. We discuss liver fibrosis as a hepatic complication and a careful follow-up maneuver for improving the outcomes of patients with chronic hepatic congestion..
8. Noriko Oyama, Kanako Kojima-Ishii, Naoko Toda, Terumichi Matsuo, Vlad Tocan, Kazuhiro Ohkubo, Utako Oba, Yuhki Koga, Nokitaka Setsu, Yuichi Yamada, Kenichi Kohashi, Yasuharu Nakashima, Yoshinao Oda, Kenji Ihara, Shouichi Ohga, Malignant transformation of phosphaturic mesenchymal tumor
A case report and literature review
, Clinical Pediatric Endocrinology, 10.1297/cpe.29.69, 2020.04, Phosphaturic mesenchymal tumor, mixed connective tissue variant (PMT-MCT) causes tumor-induced osteomalacia (TIO). Most cases follow a benign clinical course, with rare occurrences of malignant transformation. We report a case of malignant PMT-MCT and review previous malignant cases to identify predictive factors for transformation. A 13-yr-old female, who presented with hypophosphatemic rickets, elevated serum intact fibroblast growth factor 23 (FGF23) levels, and a nodule in the back, received a diagnosis of TIO because of the benign PMT histopathology. After resection of the primary tumor, regular imaging analyses did not indicate any relapse. At 17 years of age, a tumor developed in the left leg and increased in size. The resected tumor showed a histopathology of pleomorphic sarcoma positive for the TP53 mutation. Despite amputation of the affected leg, the patient died due to multiple metastases at 18 years of age. A literature review revealed that 14 out of 15 reported malignant PMT-MCT tumors occurred in adults, and found no predictive factors for malignant transformation and treatment outcome. Changes in size or number of the tumors along with intact FGF23 levels have been considered as the only sign of malignant transformation. This pediatric case report and literature review indicate the need for prolonged regular monitoring for PMT-MCT..
9. Kenichi Kohashi, Izumi Kinoshita, Yoshinao Oda, Soft Tissue Special Issue
Skeletal Muscle Tumors: A Clinicopathological Review
, Head and Neck Pathology, 10.1007/s12105-019-01113-2, 2020.03, Skeletal muscle tumors are classified into rhabdomyoma and embryonal, alveolar, spindle cell/sclerosing and pleomorphic rhabdomyosarcoma according to WHO classifications of tumors. These tumors arise mostly in the head and neck and, in childhood, represent the largest subset of soft tissue tumors. Although these skeletal muscle tumors show common immunoexpression of two myogenic regulatory factors, MyoD1 and myogenin, their molecular biological backgrounds are quite different. Therefore, treatment regimens vary a great deal depending on the histological subtype. Histopathologically, rhabdomyoma is characterized by well-demarcated lesions with no invasion of the surrounding tissue. Embryonal rhabdomyosarcoma is composed of primitive mesenchymal cells in various stages of myogenesis and shows heterogeneous nuclear staining for myogenin. Alveolar rhabdomyosarcoma, on the other hand, shows a proliferation of uniform primitive round cells arranged in alveolar patterns. The tumor cells at the periphery of alveolar structures adhere in a single layer to the fibrous septa. Diffuse and strong nuclear immunoexpression for myogenin is observed. In genetic backgrounds, almost all alveolar rhabdomyosarcomas contain a characteristic fusion gene such as PAX3/7-FOXO1. Spindle cell/sclerosing rhabdomyosarcoma is characterized by fascicularly arranged spindle-shaped cells or dense hyalinized collagenous matrix. NCOR2- or VGLL2-related gene fusions or MYOD1 (p.L122R) mutation is commonly recognized. Epithelioid rhabdomyosarcoma is a rare variant of rhabdomyosarcoma that shows a proliferation of epithelioid tumor cells having large vesicular nuclei, prominent nucleoli, and amphophilic to eosinophilic cytoplasm arranged in sheets. As these characteristic histological and molecular features are present in each subtype, it is possible to diagnose skeletal muscle tumors accurately..
10. Yamasaki R, Yonekawa T, Inamizu S, Shinoda K, Ochi H, Matsushita T, Isobe N, Tsuji G, Sadashima S, Kuma Y, Oda Y, Iwaki T, Furue M, Kira JI., A case of overlapping adult-onset linear scleroderma and Parry-Romberg syndrome presenting with widespread ipsilateral neurogenic involvement., Neuropathology., 2020.02.
11. Ueki K, Tsuchimoto A, Matsukuma Y, Torisu K, Fujisaki K, Torisu T, Yamada Y, Oda Y, Masutani K, Nakano T, Tsuruya K, Kitazono T., Hypocomplementemic urticarial vasculitis syndrome with gastrointestinal vasculitis and crescentic membranoproliferative glomerulonephritis without immune complex deposits., CEN Case Rep., 2020.02.
12. Iwasaki T, Kohashi K, Ohno M, Taguchi T, Oda Y.  取得済, Establishment and Characterization of a Novel Primitive Yolk Sac Tumour Cell Line, C587., Anticancer Res., 40(2):759-766, 2020.02.
13. Ono Y, Toyokawa G, Tagawa T, Ijichi K, Oda Y, Mori M., IgG4-Related Lung Disease Exhibiting the Invasion Into the Diaphragm: A Case Report., Ann Thorac Cardiovasc Surg., DOI: 10.5761/atcs.cr.19-00244, PMID: 32101810, 2020.02.
14. Masakazu Toya, Yuichi Yamada, Ryohei Yokoyama, Kenichi Taguchi, Kazuki Nabeshima, Teruto Isayama, Yoshinao Oda, Dedifferentiated low-grade central osteosarcoma with extensive cystic change initially treated as a simple bone cyst, Pathology Research and Practice, 10.1016/j.prp.2020.152832, 2020.01, Low-grade central osteosarcoma (LG-COS) is an uncommon variant of osteosarcoma (OS) that sometimes progresses to high-grade OS post-recurrence. We herein present a case of dedifferentiated LG-COS with extensive cystic change arising in the right iliac bone of a 26-year-old man. The LG-COS was initially diagnosed and managed as a simple bone cyst. The lesion recurred thrice, and high-grade OS was diagnosed during the third recurrence. The first lesion appeared as a typical benign cystic mass on radiography. However, a huge malignant osteoblastic mass subsequently developed in the right pelvis at the third recurrence. Extended hemipelvectomy with ipsilateral hemisacral resection was performed. Histologic analysis showed tumor necrosis and irregular neoplastic tumor osteoid, while immunohistochemistry revealed that the tumor was diffusely positive for MDM2 and CDK4. The histologic diagnosis was high-grade OS dedifferentiated from a preceding cystic lesion. Our final diagnosis of the primary lesion was LG-COS with extensive cystic change..
15. Takeshi Iwasaki, Kenichi Kohashi, Masasuke Ohno, Tomoaki Taguchi, Yoshinao Oda, Establishment and characterization of a novel primitive yolk sac tumour cell line, TC587, Anticancer research, 10.21873/anticanres.14007, 2020.01, Background/Aim: Yolk sac tumour (YST) is a rare malignant ovarian germ cell tumour that often occurs in young women or adolescents and exhibits an unfavourable outcome. To evaluate the biological behavior of carcinomas in vitro, permanent tumour cell lines are required. However, previously, only a few human YST cell lines have been established. Therefore, we aimed to establish a novel YST cell line. Materials and Methods: We established a novel YST cell line, TC587, from an adolescent patient with ovarian YST. Results: The cell line expressed AFP and SALL4, the characteristics of YST. In addition, we evaluated somatic mutations using nextgeneration sequencing and revealed some pathogenic variants, including mutations in the NRAS, KIT, KMT2C, RSF1, and TP53 genes. Conclusion: The newly established TC587 cell line may represent an effective tool for developing treatments and conducting molecular analyses for YST..
16. Yuki Yanagihara, Shintaro Hayashi, Junpei Koge, Hiroyuki Honda, Ryo Yamasaki, Yuichi Yamada, Yoshinao Oda, Toru Iwaki, Jun ichi Kira, Immunotherapy-refractory vacuolar myopathy with mucin deposition in scleromyxedema
A possible role of fibroblast growth factor 2
, Neuropathology, 10.1111/neup.12659, 2020.01, Scleromyxedema (SME) is characterized by widespread waxy papules on the skin, with mucin deposits in the upper dermis. Twenty-one SME cases of myopathy have been reported; of the cases, six showed vacuolar formation, and two showed mucin deposition. We report the first case of SME with mucin-containing vacuolated fibers. A 45-year-old woman with SME developed progressive proximal muscle weakness. Muscle biopsy revealed myopathic changes with numerous vacuoles linked to mucin in the affected muscle fibers, which were heavily immunostained for fibroblast growth factor 2 (FGF2). Despite repeated high dose oral prednisolone and intravenous immunoglobulin administrations, muscle weakness recurred continuingly, culminating in death due to congestive heart failure. Immunotherapy was partly effective in our case, although it was refractory. Treatment responsiveness in patients with SME myopathy varied; however, due to its rarity, the mechanism remains to be elucidated. To address this issue, we investigated muscle specimens immunohistochemically and detected marked upregulation of FGF2 in the affected muscle fibers of our patient. FGF2, a strong myogenesis inhibitor, may exert a suppressive effect on muscle fiber regeneration, which may have conferred refractoriness to our patient's SME myopathy..
17. Kiyota M, Oya M, Ayano M, Niiro H, Iwasaki T, Fujiwara M, Oda Y, Fujimoto K, Ida H., First Case of Pyrin-Associated Autoinflammation With Neutrophilic Dermatosis Complicated by Amyloidosis., Rheumatology (Oxford)., doi: 10.1093/rheumatology/keaa005., 2020.01.
18. Tsutsumi C, Moriyama T, Ohuchida K, Shindo K, Nagai S, Yoneda R, Fujiwara M, Oda Y, Nakamura M., Numerous lymph node metastases in early gastric cancer without preoperatively enlarged lymph nodes: a case report., Surg Case Rep., 6(1):30, 2020.01.
19. Yoshino S, Inoue K, Yoshiya K, Kurose S, Nakayama K, Morisaki K, Furuyama T, Matsumoto T, Oda Y, Mori M. 取得済 , Cystic Arterial Disease Located Only in the Media of the Popliteal Artery: A Case Report., Ann Vasc Dis. , 12(4):530-533, 2019.12.
20. Taisuke Narazaki, Motoaki Shiratsuchi, Mariko Tsuda, Yasuhiro Tsukamoto, Hiroki Muta, Toru Masuda, Daisaku Kimura, Akiko Takamatsu, Ryota Nakanishi, Eiji Oki, Minako Fujiwara, Yoshinao Oda, Yasuhiro Nakashima, Yoshihiro Ogawa, Intestinal Behçet's Disease with Primary Myelofibrosis Involving Trisomy 8, Acta Haematologica, 10.1159/000501019, 2019.11, Behçet's disease (BD) is a disorder characterized by systemic inflammation of multiple organs, including the intestines. Several studies have reported a relationship between myelodysplastic syndrome and BD, and trisomy 8 was frequently seen, especially in intestinal BD. However, the association of BD with primary myelofibrosis (PMF) has not been well documented. A 58-year-old Japanese female was diagnosed with PMF in 2014. The symptoms of PMF resolved with ruxolitinib. However, she developed fever and intestinal perforation due to multiple ulcers in the terminal ileum in 2017. Intestinal perforation recurred 1 month later, and the dose of ruxolitinib was tapered. After discontinuation of ruxolitinib, she presented with recurrent oral aphthous ulcers and uveitis. Subsequently, intestinal perforation recurred, and she was diagnosed with intestinal BD. Trisomy 8 was identified in her peripheral blood. She underwent steroid therapy, azathioprine, and infliximab. This case suggests relationships between PMF, trisomy 8, and BD..
21. Masuda Y, Tsukamoto Y, Zenitani M, Oda Y, Kinoshita I, Kohashi K, Takemoto J, Hirota S, Shibata A, Koda T, Takeshima Y. , A newborn case of jejunal ALK-negative inflammatory myofibroblastic tumor with ETV6-NTRK3 fusion., Pediatr Blood Cancer. , 66(10):e27902, 2019.10.
22. Yamamoto M, Yoshida Y, Tuneyoshi M, Gion T, Tominaga Y, Koga Y, Oda Y, Gastric Perivascular Epithelioid Cell Tumor: A Case Report", Ann Case Report, 2019.09.
23. Wang H, Yoshizumi T, Itoh S, Ikegami T, Harada N, Oda Y, Mori M. , Retroperitoneal schwannoma preoperatively diagnosed as liver metastasis from colon cancer: A case report., Int J Surg Case Rep., 2019.09.
24. Yorita K, Togashi Y, Nakagawa H, Miyazaki K, Sakata S, Baba S, Takeuchi K, Hayashi Y, Murakami I, Kuroda N, Oda Y, Kohashi K, Yamada Y, Kiyozawa D, Michal M, Michal M. , Vocal cord inflammatory myofibroblastic tumor with mucoid deposits harboring TIMP3-ALK fusion: A potential diagnostic pitfall. , Pathol Int. , 69(6):366-371, 2019.06.
25. Aya Izuwa, Gouji Toyokawa, Fumihiro Shoji, Koji Yamazaki, Seiya Momosaki, Kiyomi Furuya, Yuichi Yamada, Yoshinao Oda, Sadanori Takeo, First Case of a Primary Lung Granulosa Cell Tumor With a Mutation in the Forkhead Box L2 Gene, Journal of Thoracic Oncology, 10.1016/j.jtho.2018.12.029, 2019.05.
26. Hirose K, Saeki H, Nakashima Y, Kamori T, Fujimoto Y, Kawazoe T, Matsuoka H, Haruta Y, Sasaki S, Jogo T, Hu Q, Tsuda Y, Ando K, Oki E, Hiratsuka R, Oda Y, Mori M., Successful multidisciplinary treatment including repeated metastasectomy for recurrent squamous cell esophageal carcinoma: a case report., Surg Case Rep., 5(1):72, 2019.05.
27. Kenji Miki, Koji Yoshimoto, Yuichi Yamada, Akira Kabashima, Daisuke Kuga, Yoshinao Oda, Koji Iihara, Rapid growth of metastatic brain tumor from gastric undifferentiated pleomorphic sarcoma
A case report
, Surgical Neurology International, 10.25259/SNI-84-2019, 2019.04, Background: Brain metastasis from undifferentiated pleomorphic sarcoma (UPS) is a rare occurrence, and its clinical course is little known. In this report, we investigate a case of a rapidly growing brain metastasis from gastric UPS. Case Description: An 82-year-old man with a known gastric tumor, pathologically compatible with UPS, underwent partial gastrectomy at an outside facility. 3 months later, a 4-cm brain tumor was detected, which was completely resected. The patient was diagnosed with metastatic tumor from previously treated gastric UPS. Within 2 months of the initial resection, a large recurrent mass was detected in the same location, which was again removed. Although the patient underwent radiotherapy and chemotherapy for other metastatic tumors, he died 5 months after the second craniotomy. Conclusions: Brain metastasis from gastric UPS is rare and difficult to treat. Although aggressive treatment, such as surgical intervention, may improve patient survival in some cases, the timing of treatment is challenging because cerebral metastasis rapidly grows and and patients frequently suffer from synchronous systematic metastasis. Therefore, early detection and close follow-up of rapidly progressing brain metastasis are important to improve treatment outcomes..
28. Yugawa K, Yoshizumi T, Mano Y, Kurihara T, Yoshiya S, Takeishi K, Itoh S, Harada N, Ikegami T, Soejima Y, Kohashi K, Oda Y, Mori M. , Solitary fibrous tumor in the liver: case report and literature review., Surg Case Rep., 2019.04.
29. Takeshi Iwasaki, Hidetaka Yamamoto, Yoshinao Oda, Current Update on the Molecular Biology of Cutaneous Sarcoma
Dermatofibrosarcoma Protuberans
, Current Treatment Options in Oncology, 10.1007/s11864-019-0628-3, 2019.03, Cutaneous sarcoma is a group of malignant mesenchymal tumors primarily involving the dermis, and it is characterized by extreme clinicopathological heterogeneity. Although its occurrence rate is rare, dermatofibrosarcoma protuberans (DFSP) is one of the most common types of dermal sarcoma. DFSP grows slowly and tends to relapse locally after inadequate resection. There are various histological variants of DFSP tumors and it often mimics benign lesions such as dermatofibroma and scar, which make accurate diagnosis difficult and delayed, and some cases progress to the stage where the tumor is unresectable. Recent advancements in cancer genetics and molecular biology methods have elucidated the COL1A1-PDGFB fusion gene, some novel fusion gene variants and pathways related to DFSP pathogenesis that have resulted in the evolution of cutaneous sarcoma diagnosis and treatment. For example, some clinical studies have confirmed the efficacy of imatinib methylate, an αPDGFR-targeted therapy for unresectable or metastatic DFSP. The present review summarizes recent updates in DFSP research, diagnostics, and treatment..
30. Takashi Okumura, Kenoki Ohuchida, Shin Kibe, Chika Iwamoto, Yohei Ando, Shin Takesue, Hiromichi Nakayama, Toshiya Abe, Sho Endo, Kazuhiro Koikawa, Masafumi Sada, Kohei Horioka, Naoki Mochidome, Makoto Arita, Taiki Moriyama, Kohei Nakata, Yoshihiro Miyasaka, Takao Ohtsuka, Kazuhiro Mizumoto, Yoshinao Oda, Makoto Hashizume, Masafumi Nakamura, Adipose tissue-derived stromal cells are sources of cancer-associated fibroblasts and enhance tumor progression by dense collagen matrix, International Journal of Cancer, 10.1002/ijc.31775, 2019.03, Although recent studies revealed that adipose tissue accelerates pancreatic tumor progression with excessive extracellular matrix, key players for desmoplasia in the adipose microenvironment remains unknown. Here, we investigated the roles of adipose tissue-derived stromal cells (ASCs) in desmoplastic lesions and tumor progression by in vitro and in vivo experiments. In a three-dimensional (3-D) organotypic fat invasion model using visceral fat from CAG-EGFP mice, GFP-positive fibroblastic cells infiltrated toward cancer cells. When tumor cells were inoculated into transplanted visceral fat pads in vivo, tumor weights and stromal components were enhanced compared to subcutaneous and orthotopic tumor cells inoculated without fat pads. Expression of αSMA in established human ASCs was lower compared to cancer associated fibroblasts, and the 3-D collagen matrices produced by ASCs cultured in cancer cell-conditioned medium changed from loose to dense structures that affected the motility of cancer cells. Microarray analyses revealed upregulation of S100A4 in ASCs, while S100A4-positive stromal cells were observed at extrapancreatic invasion sites of human pancreatic cancer. The present findings indicate that ASCs are recruited to extrapancreatic invasion sites and produce dense collagen matrices that lead to enhanced tumor progression. Both inhibition of ASCs recruitment and activation could lead to a novel antistromal therapy..
31. Shin Kibe, Kenoki Ohuchida, Yohei Ando, Shin Takesue, Hiromichi Nakayama, Toshiya Abe, Sho Endo, Kazuhiro Koikawa, Takashi Okumura, Chika Iwamoto, Koji Shindo, Taiki Moriyama, Kohei Nakata, Yoshihiro Miyasaka, Masaya Shimamoto, Takao Ohtsuka, Kazuhiro Mizumoto, Yoshinao Oda, Masafumi Nakamura, Cancer-associated acinar-to-ductal metaplasia within the invasive front of pancreatic cancer contributes to local invasion, Cancer Letters, 10.1016/j.canlet.2018.12.005, 2019.03, The pancreas is an organ prone to inflammation, fibrosis, and atrophy because of an abundance of acinar cells that produce digestive enzymes. A characteristic of pancreatic cancer is the presence of desmoplasia, inflammatory cell infiltration, and cancer-associated acinar atrophy (CAA) within the invasive front. CAA is characterized by a high frequency of small ducts and resembles acinar-to-ductal metaplasia (ADM). However, the clinical significance of changes in acinar morphology, such as ADM with acinar atrophy, within the tumor microenvironment remains unclear. Here, we find that ADM within the invasive front of tumors is associated with cell invasion and desmoplasia in an orthotopic mouse model of pancreatic cancer. An analysis of resected human tumors revealed that regions of cancer-associated ADM were positive for TGFα and that this TGFα expression was associated with primary tumor size and shorter survival times. Gene expression analysis identified distinct phenotypic profiles for cancer-associated ADM, sporadic ADM and chronic pancreatitis ADM. These findings suggest that the mechanisms driving ADM differ according to the specific tissue microenvironment and that cancer-associated ADM and acinar atrophy contribute to tumor cell invasion of the local pancreatic parenchyma..
32. Yuichi Shibui, Kina Miyoshi, Kenichi Kohashi, Yoshiaki Kinoshita, Masaaki Kuda, Hidetaka Yamamoto, Tomoaki Taguchi, Yoshinao Oda, Glypican-3 expression in malignant small round cell tumors, Oncology Letters, 10.3892/ol.2019.9976, 2019.03, Malignant small round cell tumors usually progress rapidly and show resistance to chemotherapy, and it is often difficult to make a definitive diagnosis based on their histological morphology. Glypican-3 (GPC3) is a highly tumor-specific antigen, and the overexpression of GPC3 was reported in many pediatric and adult malignancies. In the present study, we investigated the GPC3 expression in pediatric malignant small round cell tumors to assess its role in the differential diagnosis of the tumors. Immunohistochemistry was performed to assess the expression of GPC3 in samples from 84 rhabdomyosarcomas (RMSs; 44 alveolar and 40 embryonal RMSs), 62 Ewing sarcomas (EWSs), 35 neuroblastomas (NBs) and two desmoplastic small round cell tumors (DSRCTs). We performed a reverse transcription-quantitative polymerase chain reaction for GPC3 to determine the GPC3 mRNA expression in samples from 66 frozen tumors (23 RMSs, 28 EWSs and 15 NBs). The serum expression levels of GPC3 were analyzed in pre-operative blood samples from two RMS and eight NB patients. In total, 25% (21/84) of the RMSs and 3% (1/35) of the NBs exhibited a focal expression of GPC3, whereas, the other specimens showed no GPC3 expression. The GPC3 mRNA expression level of the RMSs with positive GPC3 expression (n=6) was significantly higher compared with the RMSs without such expression (n=17). A total of two cases of NB showed high serum levels of GPC3, but neither tumor showed immunoreactivity for GPC3. The immunohistochemical overexpression of GPC3 may be a candidate ancillary parameter in the differential diagnosis of RMS from EWS and DSRCT..
33. Junkichi Takemoto, Masaaki Kuda, Kenichi Kohashi, Yuichi Yamada, Yutaka Koga, Izumi Kinoshita, Ryota Souzaki, Tomoaki Taguchi, Yoshinao Oda, HuC/D expression in small round cell tumors and neuroendocrine tumors
a useful tool for distinguishing neuroblastoma from childhood small round cell tumors
, Human Pathology, 10.1016/j.humpath.2018.11.004, 2019.03, The RNA-binding protein HuC/D displays a neuron-specific expression and is involved in neuronal differentiation and the maintenance of the nervous system. Here we investigated the diagnostic value of HuC/D in neuroblastomas. We evaluated 85 neuroblastic tumors: 81 neuroblastomas; 3 ganglioneuroblastomas, intermixed; 1 ganglioneuroma, maturing; and 101 other tumors consisting of 34 Ewing sarcomas, 14 nephroblastomas, 11 rhabdomyosarcomas, 15 pulmonary small cell carcinomas, 18 pancreatic neuroendocrine tumors, and 9 pheochromocytomas. Immunohistochemistry for HuC/D, PHOX2B, and tyrosine hydroxylase was performed. The immunoreactivity for HuC/D was semiquantified using the total score (TS; range, 0-8). HuC/D positivity was defined as a TS ≥6. The TS of the neuroblastic tumors (mean TS, 7.94) was significantly higher than those of the other small round cell tumors and neuroendocrine tumors (P < .001) except for the pheochromocytomas (mean TS, 6.89; P = .074). HuC/D was positive in all 85 neuroblastic tumors, 1 (2.9%) Ewing sarcoma, 1 (6.7%) pulmonary small cell carcinoma, and 8 (89%) pheochromocytomas. PHOX2B was positive in all of the neuroblastic tumors and pheochromocytomas. Tyrosine hydroxylase was positive in 80 (94%) neuroblastic tumors, 1 (9.1%) rhabdomyosarcoma, and all of the pheochromocytomas. Therefore, HuC/D serves as a highly sensitive diagnostic marker to distinguish neuroblastomas from other small round cell tumors. The combination of HuC/D and PHOX2B staining may be valuable for the diagnosis of neuroblastic tumors, especially in the assessment of small sections. HuC/D expression in tumors may be related to catecholamine production or a neural crest–derived cell origin..
34. Yuichi Shibui, Kenichi Kohashi, Ichiro Sakamoto, Kenichiro Yamamura, Yoshinao Oda, Intrahepatic cholangiocarcinoma after the Fontan procedure, Human Pathology: Case Reports, 10.1016/j.ehpc.2018.10.008, 2019.03, A long duration of Fontan circulation can cause fibrosis, cirrhosis of the liver and liver cancer. There have been some reports of hepatocellular carcinoma occurring after the Fontan procedure (FP), and we encountered a case of intrahepatic cholangiocarcinoma (ICC) after the FP. We herein report the case of 33-year-old man who developed ICC after receiving the FP. At five years of age, the patient underwent the original FP. At 16 years of age, he received total cavopulmonary connection conversion. Sixteen years later, he suffered right heart failure. Thereafter his symptoms showed repeated exacerbation and remission. One year later, he was admitted to the hospital due to the aggravation of congestive heart failure symptoms. He developed contrast nephropathy, and his renal function rapidly weakened. Computed tomography revealed multiple mass lesions in the liver. He ultimately died four months after his admission. An autopsy revealed the hepatic tumor to be ICC. Patients who have undergone the FP need to undergo a checkup with ultrasound on a regular basis..
35. Yoshihiro Komohara, Hiroto Takeya, Nanako Wakigami, Natsuki Kusada, Hirofumi Bekki, Shin Ishihara, Motohiro Takeya, Yasuharu Nakashima, Yoshinao Oda, Positive correlation between the density of macrophages and T-cells in undifferentiated sarcoma, Medical Molecular Morphology, 10.1007/s00795-018-0201-3, 2019.03, Undifferentiated sarcoma (US) is a frequent soft tissue sarcoma. Although the 10-year survival rate is around 60%, advanced US is highly resistant to chemo/radiotherapy. The tumor microenvironment (TME) is closely associated with tumor progression. However, few studies of infiltrated immune cells in US have been published. In this study, we evaluated tumor-associated macrophages (TAMs) and CD8-positive cytotoxic T lymphocytes (CTLs) in 28 cases of US. Iba1, CD163, and CD204 were used as markers for TAMs. The density of CTLs was positively correlated with the density of TAMs. However, a negative correlation was seen between the density of CTLs and the percentage of CD204-positive TAMs. We found no significant association between the density of Iba1-/CD204-/CD8-positive cells and clinicopathological factors. No significant correlation between immune cell infiltration and clinical outcome was observed. Although we found no significant association between immune cells and clinicopathological factors, these findings may provide new insight into the characterization of immune cells in the TME of US..
36. Yasuaki Hagio, Akira Shiraishi, Masataka Ishimura, Motoshi Sonoda, Katsuhide Eguchi, Hidetaka Yamamoto, Yoshinao Oda, Shouichi Ohga, Posttransplant recipient-derived CD4 + T-cell lymphoproliferative disease in X-linked hyper-IgM syndrome, Pediatric Blood and Cancer, 10.1002/pbc.27529, 2019.03.
37. Yu Nakaji, Hiroshi Saeki, Kensuke Kudou, Ryota Nakanishi, Masahiko Sugiyama, Yuichiro Nakashima, Koji Ando, Yoshinao Oda, Eiji Oki, Yoshihiko Maehara, Short- and long-term outcomes of surgical treatment for remnant gastric cancer after distal gastrectomy, Anticancer research, 10.21873/anticanres.13256, 2019.03, Background/Aim: Remnant gastric cancer (RGC) after distal gastrectomy occurs in 1-2% of patients, while the biological features of RGC are unknown. Patients and Methods: A total of 22 consecutive patients with RGC who underwent total gastrectomy were analyzed. Their disease history included either gastric cancer (n=16) or peptic ulcer (n=6). Overall, 18 underwent open total gastrectomy (OTG) and 4 underwent laparoscopic total gastrectomy (LTG). Results: The mean number of lymph nodes dissected and metastatic lymph nodes was larger in the Ulcer group than in the Carcinoma group (p<0.005). The mean operation time was longer in the LTG than OTG (p<0.005). The median blood loss tended to be smaller in the LTG (p=0.090). Five-year overall and recurrence-free survival rates were 94% and 81%, respectively. Conclusion: The status of lymph node metastasis after surgery for RGC should be cautiously considered in the context of disease history. Both LTG and OTG can be treatment options for RGC..
38. Hirose K, Saeki H, Nakashima Y, Kamori T, Fujimoto Y, Kawazoe T, Matsuoka H, Haruta Y, Sasaki S, Jogo T, Hu Q, Tsuda Y, Ando K, Oki E, Hiratsuka R, Oda Y, Mori M. , Successful multidisciplinary treatment including repeated metastasectomy for recurrent squamous cell esophageal carcinoma: a case report., Surg Case Rep., 2019.03.
39. Gouji Toyokawa, Kazuki Takada, Tetsuzo Tagawa, Ryuji Hamamoto, Yuichi Yamada, Mototsugu Shimokawa, Yoshinao Oda, Yoshihiko Maehara, A Positive Correlation Between the EZH2 and PD-L1 Expression in Resected Lung Adenocarcinomas, Annals of Thoracic Surgery, 10.1016/j.athoracsur.2018.08.056, 2019.02, Background: Enhancer of zeste homolog 2 (EZH2) is reported to be involved in lung cancer pathogenesis via the epigenetic regulation of various genes. Recently, EZH2 was shown to control mechanisms of adaptive resistance to immunotherapy in melanoma; however, the association between EZH2 and programmed death-ligand 1 (PD-L1), which reflects the tumor microenvironment, remains poorly understood. Methods: A total of 428 patients with resected lung adenocarcinoma were analyzed for their EZH2 and PD-L1 expression by immunohistochemistry and evaluated to determine the association between the EZH2 and PD-L1 expression. Results: Among 428 patients, the EZH2 expression was identified in 219 (51.2%) patients, while the PD-L1 expression was observed in 88 (20.6%) patients. The recurrence-free and overall survival were significantly shorter in patients with the EZH2 expression than in those without it. A multivariate analysis showed that EZH2 remained an independent prognosticator for recurrence-free and overall survival. Patients with the EZH2-positive lung adenocarcinoma exhibited a significantly higher expression of PD-L1 than did those without it. A logistic regression analysis with backward elimination revealed that the presence of lymphatic and vessel invasion and PD-L1 positivity were independently associated with the EZH2 expression, while age over 70 years, the presence of vessel invasion, wild-type epidermal growth factor receptor, and EZH2 positivity were significantly associated with the PD-L1 expression. Conclusions: EZH2-expressing lung adenocarcinomas were shown to express the PD-L1 protein more frequently than were nonexpressing lesions. This study provides the first evidence of a possible association between the EZH2 and PD-L1 expression in patients with resected lung adenocarcinoma..
40. Satoshi Obata, Koichiro Yoshimaru, Kosuke Kirino, Tomoko Izaki, Satoshi Ieiri, Atsuyuki Yamataka, Tsugumichi Koshinaga, Jun Iwai, Hitoshi Ikeda, Hiroshi Matsufuji, Yoshinao Oda, Tomoaki Taguchi, Acquired isolated hypoganglionosis as a distinct entity
results from a nationwide survey
, Pediatric surgery international, 10.1007/s00383-018-4398-y, 2019.02, Purpose: Acquired isolated hypoganglionosis (A-IH) is a late-onset intestinal pseudo-obstruction disorder and shows different pathophysiological findings from congenital isolated hypoganglionosis (C-IH). In this study, we retrospectively examined five cases of A-IH and investigated the features of A-IH. Methods: Five cases of A-IH were extracted from a nationwide retrospective cohort study in 10 years, from which totally 355 cases of Allied Disorders of Hirschsprung’s Disease (ADHD) were collected. Results: Ages of onset were between 13 and 17 years in three cases, and 4 years and 4 months in ones. Initial symptoms were abdominal distension and/or chronic constipation in 4 cases, whereas one exhibited intestinal perforation. Affected lesions varied from case to case, extending various length of intestinal tracts. All cases underwent multiple operations (average: 4.6 times), such as enterostomy, resection of dilated intestines, and/or pull-through. Pathological findings showed the decreased numbers of ganglion cells and degeneration of ganglion cells, whereas the size of the plexus was normal. Currently, all cases were alive and almost all eat regular food without requiring parenteral feeding. Conclusion: A-IH is rare, but distinct entity characterized by different clinical courses and pathological findings from those of C-IH. The outcome is considered to be favorable after a resection of affected intestine..
41. Kazuki Takada, Kenichi Kohashi, Mototsugu Shimokawa, Akira Haro, Atsushi Osoegawa, Tetsuzo Tagawa, Takashi Seto, Yoshinao Oda, Yoshihiko Maehara, Co-expression of IDO1 and PD-L1 in lung squamous cell carcinoma
Potential targets of novel combination therapy
, Lung Cancer, 10.1016/j.lungcan.2018.12.008, 2019.02, Objectives: Combination therapy with an inhibitor of indoleamine 2, 3-dioxygenase 1 (IDO1) and an agent targeting programmed cell death-1 (PD-1)/programmed cell death-ligand 1 (PD-L1) is expected to be a novel and effective treatment option for various solid tumors including non-small cell lung cancer (NSCLC). Therefore, it is important to elucidate the clinical and pathological features of tumors with IDO1/PD-L1 co-expression and the association between IDO1/PD-L1 co-expression and efficacy of combination therapy in NSCLC patients. In this study, we examined the prognostic impact of IDO1/PD-L1 co-expression and its relationship with tumor-infiltrating lymphocytes (TILs) in primary lung squamous cell carcinoma (SCC). Materials and methods: The expression levels of IDO1, PD-L1, Ki-67, cluster of differentiation 3 (CD3), CD4, and CD8 in 202 patients with surgically resected primary lung SCC were evaluated by immunohistochemistry. Results: Among 202 patients, 176 (87.1%) were positive for IDO1 expression, 106 (52.5%) were positive for PD-L1 expression, and 99 (49.0%) showed co-expression of IDO1/PD-L1 proteins. Fisher's exact test showed a significant association between IDO1 and PD-L1 tumor proportion scores (P = 0.0011). Kaplan–Meier curve showed that PD-L1 alone and co-expression of IDO1 and PD-L1 were significantly associated with shorter overall survival, but IDO1 alone was not (log rank test: P = 0.0122, P = 0.0303 and P = 0.5168, respectively). The Ki-67 labeling index was significantly higher in patients with co-expression of IDO1 and PD-L1 than in patients without co-expression (Student's t-test: P = 0.0005). Moreover, IDO1/PD-L1 co-expression was significantly associated with high CD3, CD4, and CD8 expression (Fisher's exact test: P = 0.0033, P = 0.0003, and P < 0.0001, respectively). Conclusions: IDO1 expression correlated to PD-L1 expression, and co-expression of IDO1 and PD-L1 may be important targets for immunotherapy in lung SCC..
42. Yoshikawa N, Tazaki T, Hatanaka M, Oda Y, Matsumoto N, Sonoda J, Ikeda R. , Drug-drug interactions among drugs prescribed for nontuberculous mycobacterial infection and epilepsy: A case report., J Clin Pharm Ther., 2019.02.
43. Yasuyuki Masuda, Yoshitane Tsukamoto, Masahiro Zenitani, Yoshinao Oda, Izumi Kinoshita, Kenichi Kohashi, Junkichi Takemoto, Seiichi Hirota, Akio Shibata, Tsubasa Koda, Yasuhiro Takeshima, A newborn case of jejunal ALK-negative inflammatory myofibroblastic tumor with ETV6-NTRK3 fusion, Pediatric Blood and Cancer, 10.1002/pbc.27902, 2019.01.
44. Shinkichi Takamori, Gouji Toyokawa, Mototsugu Shimokawa, Fumihiko Kinoshita, Yuka Kozuma, Taichi Matsubara, Naoki Haratake, Takaki Akamine, Fumihiko Hirai, Tetsuzo Tagawa, Yoshinao Oda, Yoshihiko Maehara, A novel prognostic marker in patients with non-small cell lung cancer
Musculo-immuno-nutritional score calculated by controlling nutritional status and creatine kinase
, Journal of Thoracic Disease, 10.21037/jtd.2019.01.76, 2019.01, Background: Controlling nutritional status (CONUT) and skeletal muscle area (SMA) are both useful prognostic factors in patients with non-small cell lung cancer (NSCLC). We hypothesized that low serum creatine kinase (CK) would be a surrogate of decreased SMA, and defined a novel prognostic factor, CONUT/CK score (CNKS). The aim of this study was to elucidate the clinical significance of CNKS in NSCLC patients. Methods: One hundred and eighty-nine patients who underwent surgical resection of NSCLC and whose preoperative computed tomography images were available were enrolled. The CNKS was calculated by summing CONUT score and CK score, which was defined as 0 if the CK concentration is within normal range, and 2 if it is under lower limit. The optimal cut-off values of CNKS and CONUT score were 4 and 2, respectively. Results: Low CK was significantly associated with decreased SMA (P=0.012). The high CNKS group was significantly associated with men and smoking history (P=0.006 and P=0.015, respectively). The high CNKS group had significantly shorter overall survival (OS) and disease-free survival (DFS) (P<0.001 and P=0.003, respectively) than the low CNKS group. The CNKS was found to be an independent prognostic factor for OS and DFS (P=0.012 and P=0.017, respectively), while CONUT score was not. The CNKS was a novel significant predictor of a poor prognosis in patients with NSCLC. Conclusions: The nutritional status combined with skeletal muscle index was suggested to provide more useful prognostic information than alone, which should be investigated in further prospective studies with a larger cohort..
45. Yutaka Koga, Minako Hirahashi, Yoshihiro Ohishi, Yoshinao Oda, Clinicopathological features and phenotypic classification of de novo-type colorectal carcinomas differ from those of colorectal carcinomas derived from flat adenomas, Pathology International, 10.1111/pin.12803, 2019.01, Since adenoma components disappear with tumor progression, it is not known whether colorectal carcinomas (CRCs) are derived from an adenoma–carcinoma sequence or are de novo. We compared 38 cases of ≤10-mm flat CRCs without an adenoma component (de novo type) with 39 cases of ≤10-mm flat CRCs with an adenoma component (carcinoma in adenoma (CIA) type). Compared to the CIA type, the de novo-type CRCs were more frequently located in the proximal colon; more frequently invaded submucosa, and more frequently had venous permeation. Regarding the phenotypic classification based on the immunohistochemical expressions of CD10, MUC2 and MUC5AC, the incidence of unclassified type (CD10−, MUC2− and MUC5AC−) was significantly more frequent in the de novo (32%) than CIA (5%) type. In one de novo-type case, mismatch repair (MMR) protein loss was judged, because MLH1 and PMS2 protein expressions were immunohistochemically negative. BRAF mutation (V600E) was seen in one de novo-type case and two CIA-type cases, but none of these cases had MMR protein loss. In conclusion, small-intestinal type (CD10+ and MUC5AC−) is the most common in flat CRC and unclassified type is mainly characteristic of de novo type. In this study, small flat CRCs with BRAF mutation do not have MMR protein loss..
46. Masato Yoshimoto, Yuichi Yamada, Shin Ishihara, Kenichi Kohashi, Yu Toda, Yoshihiro Ito, Hidetaka Yamamoto, Masutaka Furue, Yasuharu Nakashima, Yoshinao Oda, Comparative study of myxofibrosarcoma with undifferentiated pleomorphic sarcoma
Histopathologic and clinicopathologic review
, American Journal of Surgical Pathology, 10.1097/PAS.0000000000001389, 2019.01, Myxofibrosarcoma (MFS) is a malignant fibroblastic/ myofibroblastic neoplasm with the prominent myxoid area. It has the clinical features of frequent local recurrence and occasional distant metastasis. Morphologically, MFS is occasionally difficult to distinguish from undifferentiated pleomorphic sarcoma (UPS), especially in the case of high-grade MFS. Here, we reviewed clinical and histologic data of 162 MFS cases and 43 UPS cases. MFS was distinguished from UPS with the criterion of 10% myxoid area as a cutoff value. Overall, 52MFS (34.4%) and 9 UPS (20.9%) cases showed local recurrence, 18 MFS (12.2%) and 19 UPS (44.2%) cases developed distant metastasis, and 13 MFS (9.5%) and 14 UPS (32.6%) cases resulted in tumor-related death. Statistically, MFS had a better prognosis than UPS. Moreover, MFS with less myxoid area had a tendency to present a poorer prognosis. FNCLCC grade was a statistically significant prognostic factor (distant metastasis: P=0.0021, tumor-related death: P=0.0021). Cellularity and nuclear atypia had only a statistical tendency for associations with a poorer prognosis. The overall survival rate of MFS after transformation into a UPS-like condition (<10% myxoid area) was close to that of UPS. It was suggested that MFS is a biologically distinct tumor from UPS, andMFS with less myxoid area had a tendency to present a poorer prognosis. We considered that evaluation of the amount of myxoid area, cellularity, and nuclear atypia may be important as prognostic predictors. MFS may become similar to histologic malignancy of UPS in terms of morphology and biology via local recurrence..
47. Rina Jiromaru, Hidetaka Yamamoto, Ryuji Yasumatsu, Takahiro Hongo, Yui Nozaki, Kazuki Hashimoto, Kenichi Taguchi, Muneyuki Masuda, Takashi Nakagawa, Yoshinao Oda, HPV-related Sinonasal Carcinoma
Clinicopathologic Features, Diagnostic Utility of p16 and Rb Immunohistochemistry, and EGFR Copy Number Alteration
, American Journal of Surgical Pathology, 10.1097/PAS.0000000000001410, 2019.01, The prevalence and prognostic value of human papillomavirus (HPV) infection and epidermal growth factor receptor (EGFR) alteration in sinonasal squamous cell carcinoma (SNSCC) are not known. The reliability of p16 overexpression as a surrogate for HPV infection in SNSCC is also unclear. We investigated the prognostic and diagnostic significances of HPV infection, EGFR alteration, and p16 expression in SNSCC. We analyzed high-risk HPV infection by HPV-RNA in situ hybridization and EGFR gene copy number gain (CNG) by chromogenic in situ hybridization and by determining the protein expressions of p16, Rb, and EGFR by immunohistochemistry in 101 SNSCC cases. HPV infection (n=9, 8.9%) and p16 overexpression (n=15, 14.9%) were associated with better overall survival (P=0.0042 and 0.005, respectively). The HPV+ cases were located predominantly at the nasal cavity with nonkeratinizing histology and partial loss of Rb. Notably, 40% (6/15) of p16+ SNSCCs were HPV-. Two of these cases showed complete loss of Rb expression by immunohistochemistry, suggesting a reason for the above discrepancy. EGFR CNG, detected in 30.5% of the SNSCCs, was correlated with EGFR protein overexpression (P=0.0001). HPV infection and EGFR CNG were mutually exclusive. The HPV+/EGFR CNG- group had significantly better overall survival than the HPV-/EGFR CNG- and HPV-/EGFR CNG+ groups (P=0.0471 and 0.0343, respectively). Our results suggest that HPV infection is a favorable prognostic marker in SNSCC, but p16 is not a perfect surrogate marker; the Rb expression pattern may improve the diagnostic accuracy. The molecular subclassification of SNSCCs based on HPV infection and EGFR copy number status might provide important information for therapeutic strategies..
48. Hidetaka Yamamoto, Shin Ishihara, Yu Toda, Yoshinao Oda, Histone H3.3 mutation in giant cell tumor of bone
an update in pathology
, Medical Molecular Morphology, 10.1007/s00795-019-00238-1, 2019.01, Giant cell tumor of bone (GCTB) is a locally aggressive bone tumor that frequently shows local recurrence and occasionally shows malignant transformation to high-grade sarcoma. Histologically, conventional GCTB is composed mainly of three types of cells: mononuclear neoplastic cells with an osteoblastic precursor phenotype, mononuclear histiocytic cells, and osteoclast-like multinucleated giant cells. These cells interact with each other via the RANKL-RANK axis and other mechanisms for tumor formation. The vast majority of GCTBs were recently revealed to harbor H3F3A p.G34W mutation, and a minor subset have H3F3A p.G34L, p.G34M, p.G34R, or p.G34V mutation. H3.3 G34W mutant-specific immunohistochemistry is a highly sensitive and specific surrogate marker for H3F3A p.G34W mutation in GCTB and thus useful for differential diagnoses of histological mimics. H3.3 mutant-specific immunohistochemistry has also contributed to the understanding of the bone-forming ability of neoplastic cells of GCTB and the remarkable new bone formation after treatment with denosumab, an inhibitor of RANKL. In primary and secondary malignant GCTBs, the H3F3A gene allele can be preserved or lost with malignant transformation..
49. Yuka Kozuma, Gouji Toyokawa, Yuichi Yamada, Fumihiro Shoji, Koji Yamazaki, Yoshinao Oda, Sadanori Takeo, Spread through air spaces in non-small cell lung cancer, Journal of Thoracic Disease, 10.21037/jtd.2019.08.97, 2019.01.
50. Kenji Yorita, Yuki Togashi, Hideyuki Nakagawa, Katsushi Miyazaki, Seiji Sakata, Satoko Baba, Kengo Takeuchi, Yoshihiro Hayashi, Ichiro Murakami, Naoto Kuroda, Yoshinao Oda, Kenichi Kohashi, Yuichi Yamada, Daisuke Kiyozawa, Michael Michal, Michal Michal, Vocal cord inflammatory myofibroblastic tumor with mucoid deposits harboring TIMP3–ALK fusion
A potential diagnostic pitfall
, Pathology International, 10.1111/pin.12796, 2019.01, A 35-year-old Japanese man who had experienced hoarseness for 10 years presented with a vocal cord lesion. A gross examination revealed a left vocal cord polyp occupying two-thirds of the vocal space. The endoscopically resected lesion contained scattered atypical fibroblastic, stellate, or ganglion-like cells with mucoid stroma. Vacuolated cells were also seen. Lymphoplasmacytic infiltrate was largely undetectable. A vocal cord polyp was first suspected, but well-differentiated liposarcoma and inflammatory myofibroblastic tumor (IMT) were included in the differential diagnoses. The tumor cells were positive for anaplastic lymphoma kinase (ALK), calponin, and vimentin, and negative for other smooth muscle markers by immunohistochemistry. Structures resembling myofibroblasts were not observed by electron microscopy, which confirmed abundant rough endoplasmic reticulum in the tumor cells and accumulated lipid droplets in some tumor cells. ALK gene rearrangement was detected by fluorescence in situ hybridization, and TIMP3–ALK fusion was confirmed by 5′ rapid amplification of cDNA ends. We diagnosed the lesion as an IMT, and an ALK-rearranged stellate cell tumor may be postulated. This is the first report of a fusion partner gene of ALK in a case of laryngeal IMT..
51. Chihiro Sakaguchi, Kenji Ashida, Kenichi Kohashi, Kenji Ohe, Yoichi Fujii, Seiichi Yano, Yayoi Matsuda, Shohei Sakamoto, Ryuichi Sakamoto, Yoshinao Oda, Masatoshi Nomura, Yoshihiro Ogawa, A case of autonomous cortisol secretion in a patient with subclinical Cushing's syndrome, GNAS mutation, and paradoxical cortisol response to dexamethasone, BMC Endocrine Disorders, 10.1186/s12902-019-0345-8, 2019.01, Background: Increased urinary free cortisol in response to the oral administration of dexamethasone is a paradoxical reaction mainly reported in patients with primary pigmented nodular adrenocortical disease. Here, we describe the first case of subclinical Cushing's syndrome represented by autonomous cortisol secretion and paradoxical response to oral dexamethasone administration, harboring an activating mutation in the α subunit of the stimulatory G protein (GNAS). Case presentation: A 65-year-old woman was diagnosed with subclinical Cushing's syndrome during an evaluation for bilateral adrenal masses. Tumors of unknown origin were found in the heart, brain, thyroid gland, colon, pancreas, and both adrenal glands. Adenocarcinoma of the sigmoid colon and systemic brown-patchy skin pigmentation were also present. Her urinary cortisol levels increased in response to oral dexamethasone, while serum dehydroepiandrosterone-sulfate was not suppressed. After right adrenalectomy, genetic analysis of the resected tumor revealed the somatic GNAS activating mutation, p.R201H. Paradoxical urinary cortisol response persisted even after unilateral adrenal resection, although serum and urinary cortisol levels were attenuated. Conclusions: This patient harbored a GNAS activating mutation, and presented with a mild cortisol- and androgen-producing adrenal adenoma. Administration of oral dexamethasone paradoxically increased cortisol levels, possibly via the stimulation of the cyclic adenosine monophosphate-dependent protein kinase A signaling pathway, which is seen in patients with pigmented nodular adrenocortical disease or Carney complex. GNAS mutations may provide clues to the mechanisms of hyper-function and tumorigenesis in the adrenal cortex, especially in bilateral adrenal masses accompanied by multiple systemic tumors. Examining GNAS mutations could help physicians detect extra-adrenal malignancies, which may contribute to an improved prognosis for patients with this type of Cushing's syndrome..
52. Yasuyuki Masuda, Yoshitane Tsukamoto, Masahiro Zenitani, Yoshinao Oda, Izumi Kinoshita, Kenichi Kohashi, Junkichi Takemoto, Seiichi Hirota, Akio Shibata, Tsubasa Koda, Yasuhiro Takeshima, A newborn case of jejunal ALK-negative inflammatory myofibroblastic tumor with ETV6-NTRK3 fusion, Pediatric Blood and Cancer, 10.1002/pbc.27902, 2019.01.
53. Shinkichi Takamori, Gouji Toyokawa, Mototsugu Shimokawa, Fumihiko Kinoshita, Yuka Kozuma, Taichi Matsubara, Naoki Haratake, Takaki Akamine, Fumihiko Hirai, Tetsuzo Tagawa, Yoshinao Oda, Yoshihiko Maehara, A novel prognostic marker in patients with non-small cell lung cancer
Musculo-immuno-nutritional score calculated by controlling nutritional status and creatine kinase
, Journal of Thoracic Disease, 10.21037/jtd.2019.01.76, 2019.01, Background: Controlling nutritional status (CONUT) and skeletal muscle area (SMA) are both useful prognostic factors in patients with non-small cell lung cancer (NSCLC). We hypothesized that low serum creatine kinase (CK) would be a surrogate of decreased SMA, and defined a novel prognostic factor, CONUT/CK score (CNKS). The aim of this study was to elucidate the clinical significance of CNKS in NSCLC patients. Methods: One hundred and eighty-nine patients who underwent surgical resection of NSCLC and whose preoperative computed tomography images were available were enrolled. The CNKS was calculated by summing CONUT score and CK score, which was defined as 0 if the CK concentration is within normal range, and 2 if it is under lower limit. The optimal cut-off values of CNKS and CONUT score were 4 and 2, respectively. Results: Low CK was significantly associated with decreased SMA (P=0.012). The high CNKS group was significantly associated with men and smoking history (P=0.006 and P=0.015, respectively). The high CNKS group had significantly shorter overall survival (OS) and disease-free survival (DFS) (P<0.001 and P=0.003, respectively) than the low CNKS group. The CNKS was found to be an independent prognostic factor for OS and DFS (P=0.012 and P=0.017, respectively), while CONUT score was not. The CNKS was a novel significant predictor of a poor prognosis in patients with NSCLC. Conclusions: The nutritional status combined with skeletal muscle index was suggested to provide more useful prognostic information than alone, which should be investigated in further prospective studies with a larger cohort..
54. Yohei Nakashima, Takao Ohtsuka, So Nakamura, Yasuhisa Mori, Kohei Nakata, Yoshihiro Miyasaka, Kosei Ishigami, Ryota Matsuda, Yoshinao Oda, Masafumi Nakamura, Clinicopathological characteristics of non-functioning cystic pancreatic neuroendocrine tumors, Pancreatology, 10.1016/j.pan.2018.11.010, 2019.01, Background/objectives: The biological features of cystic pancreatic neuroendocrine tumors (PNETs) remain unclear. The aim of this study was to clarify the clinicopathological characteristics of non-functioning PNETs (NF-PNETs) with a cystic component. Methods: The medical records of 75 patients with NF-PNETs who had undergone resection in our institution were retrospectively reviewed. Clinicopathological factors were compared between PNETs with and without a cystic component. Expression of somatostatin 2 receptor (SSTR-2) was also analyzed. Results: Cystic PNETs were diagnosed in 14 patients (19%). The proportion of men was significantly higher for cystic than solid PNETs (79% vs. 44%, P < 0.05) and cystic PNETs were significantly larger than solid PNETs (25 mm vs. 17 mm, P < 0.01). However, there were no significant differences in the prevalence of lymph node metastases (14% vs. 10%, P = 0.64), hepatic metastasis (7% vs. 3%, P = 0.54), or disease-free survival rate (both 86%, P = 0.29) between PNETs with and without a cystic component. SSTR-2 expression was more frequently observed in PNETs with a cystic component than in those without (100% vs. 70%, P < 0.01). Conclusions: Although cystic PNETs were larger upon diagnosis than solid PNETs in this study, prognosis after surgical resection did not differ significantly between these types of PNET. Somatostatin receptor scintigraphy and somatostatin analogues may be more useful for diagnosing and treating cystic PNETs, respectively..
55. Yutaka Koga, Minako Hirahashi, Yoshihiro Ohishi, Yoshinao Oda, Clinicopathological features and phenotypic classification of de novo-type colorectal carcinomas differ from those of colorectal carcinomas derived from flat adenomas, Pathology International, 10.1111/pin.12803, 2019.01, Since adenoma components disappear with tumor progression, it is not known whether colorectal carcinomas (CRCs) are derived from an adenoma–carcinoma sequence or are de novo. We compared 38 cases of ≤10-mm flat CRCs without an adenoma component (de novo type) with 39 cases of ≤10-mm flat CRCs with an adenoma component (carcinoma in adenoma (CIA) type). Compared to the CIA type, the de novo-type CRCs were more frequently located in the proximal colon; more frequently invaded submucosa, and more frequently had venous permeation. Regarding the phenotypic classification based on the immunohistochemical expressions of CD10, MUC2 and MUC5AC, the incidence of unclassified type (CD10−, MUC2− and MUC5AC−) was significantly more frequent in the de novo (32%) than CIA (5%) type. In one de novo-type case, mismatch repair (MMR) protein loss was judged, because MLH1 and PMS2 protein expressions were immunohistochemically negative. BRAF mutation (V600E) was seen in one de novo-type case and two CIA-type cases, but none of these cases had MMR protein loss. In conclusion, small-intestinal type (CD10+ and MUC5AC−) is the most common in flat CRC and unclassified type is mainly characteristic of de novo type. In this study, small flat CRCs with BRAF mutation do not have MMR protein loss..
56. Masato Yoshimoto, Yuichi Yamada, Shin Ishihara, Kenichi Kohashi, Yu Toda, Yoshihiro Ito, Hidetaka Yamamoto, Masutaka Furue, Yasuharu Nakashima, Yoshinao Oda, Comparative study of myxofibrosarcoma with undifferentiated pleomorphic sarcoma
Histopathologic and clinicopathologic review
, American Journal of Surgical Pathology, 10.1097/PAS.0000000000001389, 2019.01, Myxofibrosarcoma (MFS) is a malignant fibroblastic/ myofibroblastic neoplasm with the prominent myxoid area. It has the clinical features of frequent local recurrence and occasional distant metastasis. Morphologically, MFS is occasionally difficult to distinguish from undifferentiated pleomorphic sarcoma (UPS), especially in the case of high-grade MFS. Here, we reviewed clinical and histologic data of 162 MFS cases and 43 UPS cases. MFS was distinguished from UPS with the criterion of 10% myxoid area as a cutoff value. Overall, 52MFS (34.4%) and 9 UPS (20.9%) cases showed local recurrence, 18 MFS (12.2%) and 19 UPS (44.2%) cases developed distant metastasis, and 13 MFS (9.5%) and 14 UPS (32.6%) cases resulted in tumor-related death. Statistically, MFS had a better prognosis than UPS. Moreover, MFS with less myxoid area had a tendency to present a poorer prognosis. FNCLCC grade was a statistically significant prognostic factor (distant metastasis: P=0.0021, tumor-related death: P=0.0021). Cellularity and nuclear atypia had only a statistical tendency for associations with a poorer prognosis. The overall survival rate of MFS after transformation into a UPS-like condition (<10% myxoid area) was close to that of UPS. It was suggested that MFS is a biologically distinct tumor from UPS, andMFS with less myxoid area had a tendency to present a poorer prognosis. We considered that evaluation of the amount of myxoid area, cellularity, and nuclear atypia may be important as prognostic predictors. MFS may become similar to histologic malignancy of UPS in terms of morphology and biology via local recurrence..
57. Rina Jiromaru, Hidetaka Yamamoto, Ryuji Yasumatsu, Takahiro Hongo, Yui Nozaki, Kazuki Hashimoto, Kenichi Taguchi, Muneyuki Masuda, Takashi Nakagawa, Yoshinao Oda, HPV-related Sinonasal Carcinoma
Clinicopathologic Features, Diagnostic Utility of p16 and Rb Immunohistochemistry, and EGFR Copy Number Alteration
, American Journal of Surgical Pathology, 10.1097/PAS.0000000000001410, 2019.01, The prevalence and prognostic value of human papillomavirus (HPV) infection and epidermal growth factor receptor (EGFR) alteration in sinonasal squamous cell carcinoma (SNSCC) are not known. The reliability of p16 overexpression as a surrogate for HPV infection in SNSCC is also unclear. We investigated the prognostic and diagnostic significances of HPV infection, EGFR alteration, and p16 expression in SNSCC. We analyzed high-risk HPV infection by HPV-RNA in situ hybridization and EGFR gene copy number gain (CNG) by chromogenic in situ hybridization and by determining the protein expressions of p16, Rb, and EGFR by immunohistochemistry in 101 SNSCC cases. HPV infection (n=9, 8.9%) and p16 overexpression (n=15, 14.9%) were associated with better overall survival (P=0.0042 and 0.005, respectively). The HPV+ cases were located predominantly at the nasal cavity with nonkeratinizing histology and partial loss of Rb. Notably, 40% (6/15) of p16+ SNSCCs were HPV-. Two of these cases showed complete loss of Rb expression by immunohistochemistry, suggesting a reason for the above discrepancy. EGFR CNG, detected in 30.5% of the SNSCCs, was correlated with EGFR protein overexpression (P=0.0001). HPV infection and EGFR CNG were mutually exclusive. The HPV+/EGFR CNG- group had significantly better overall survival than the HPV-/EGFR CNG- and HPV-/EGFR CNG+ groups (P=0.0471 and 0.0343, respectively). Our results suggest that HPV infection is a favorable prognostic marker in SNSCC, but p16 is not a perfect surrogate marker; the Rb expression pattern may improve the diagnostic accuracy. The molecular subclassification of SNSCCs based on HPV infection and EGFR copy number status might provide important information for therapeutic strategies..
58. Hidetaka Yamamoto, Shin Ishihara, Yu Toda, Yoshinao Oda, Histone H3.3 mutation in giant cell tumor of bone
an update in pathology
, Medical Molecular Morphology, 10.1007/s00795-019-00238-1, 2019.01, Giant cell tumor of bone (GCTB) is a locally aggressive bone tumor that frequently shows local recurrence and occasionally shows malignant transformation to high-grade sarcoma. Histologically, conventional GCTB is composed mainly of three types of cells: mononuclear neoplastic cells with an osteoblastic precursor phenotype, mononuclear histiocytic cells, and osteoclast-like multinucleated giant cells. These cells interact with each other via the RANKL-RANK axis and other mechanisms for tumor formation. The vast majority of GCTBs were recently revealed to harbor H3F3A p.G34W mutation, and a minor subset have H3F3A p.G34L, p.G34M, p.G34R, or p.G34V mutation. H3.3 G34W mutant-specific immunohistochemistry is a highly sensitive and specific surrogate marker for H3F3A p.G34W mutation in GCTB and thus useful for differential diagnoses of histological mimics. H3.3 mutant-specific immunohistochemistry has also contributed to the understanding of the bone-forming ability of neoplastic cells of GCTB and the remarkable new bone formation after treatment with denosumab, an inhibitor of RANKL. In primary and secondary malignant GCTBs, the H3F3A gene allele can be preserved or lost with malignant transformation..
59. Yoshihiro Miyasaka, Takao Ohtsuka, Ryuichiro Kimura, Ryota Matsuda, Yasuhisa Mori, Kohei Nakata, Daisuke Kakihara, Nao Fujimori, Takamasa Ohno, Yoshinao Oda, Masafumi Nakamura, Neoadjuvant Chemotherapy with Gemcitabine Plus Nab-Paclitaxel for Borderline Resectable Pancreatic Cancer Potentially Improves Survival and Facilitates Surgery, Annals of Surgical Oncology, 10.1245/s10434-019-07309-8, 2019.01, Background: Accumulation of evidence suggests that neoadjuvant chemotherapy improves the outcomes of borderline resectable pancreatic cancer (BRPC). Gemcitabine plus nab-paclitaxel (GnP) has been widely accepted as systemic chemotherapy for unresectable pancreatic cancer and reportedly results in remarkable tumor shrinkage. This study was performed to evaluate the safety and efficacy of neoadjuvant chemotherapy using neoadjuvant GnP for BRPC. Methods: The medical records of 57 patients who underwent treatment of BRPC from 2010 to 2017 were retrospectively reviewed. The patient characteristics and short- and intermediate-term outcomes were compared between the GnP and upfront surgery (UFS) groups. Results: The GnP group comprised 31 patients and the UFS group comprised 26 patients. The patient characteristics were comparable with the exception of a higher prevalence of arterial involvement in the GnP group. Twenty-seven of the 31 patients (87%) in the GnP group and all 26 patients in the UFS group underwent resection. The GnP group showed a significantly shorter operation time (429 vs. 509.5 min, p = 0.0068), less blood loss (760 vs. 1324 ml, p = 0.0115), and a higher R0 resection rate (100% vs. 77%, p = 0.0100) than the UFS group. Postoperative complications and hospital stay were comparable between the two groups, and no treatment-related mortality occurred in either group. Both the disease-free survival and overall survival times were significantly longer in the GnP group (p = 0.0018 and p = 0.0024, respectively). Conclusions: Neoadjuvant GnP is a safe and effective treatment strategy for BRPC. It potentially improves patients’ prognosis and facilitates surgical procedures..
60. Takako Ito, Atsunobu Takeda, Kohta Fujiwara, Eiichi Hasegawa, Shintaro Nakao, Yoshihiro Ohishi, Yoshinao Oda, Hiroshi Yoshikawa, Koh Hei Sonoda, Risk factors for failure of vitrectomy cell block technique in cytological diagnosis of vitreoretinal lymphoma, Graefe's Archive for Clinical and Experimental Ophthalmology, 10.1007/s00417-019-04266-6, 2019.01, Purpose: To determine the factors that may affect the accuracy of vitrectomy cell block technique in detecting atypical lymphoid cells in patients with vitreoretinal lymphoma (VRL). Methods: We retrospectively reviewed 43 eyes in 39 patients who underwent vitrectomy for definitive histological diagnosis of VRL with vitrectomy cell block technique and/or smear preparation at Kyushu University Hospital from January 2001 to March 2016. The association of detection of atypical lymphoid cells using vitrectomy cell block technique with the following factors was assessed using logistic regression analysis: age at diagnosis, sex, presence or absence of concurrent cataract surgery with vitrectomy, clinical grading of vitreous haze, presence or absence of subretinal tumor infiltration, interval between initial symptoms and vitrectomy, and presence or absence of systemic corticosteroid therapy before vitrectomy. Results: Atypical lymphoid cells were more significantly detected using vitrectomy cell block technique compared to that using smear preparation (p = 0.018). After adjusting for age and sex, concurrent cataract surgery (odds ratio [OR], 10.41; 95% confidence interval [CI], 1.42–76.41) and subretinal tumor infiltration (OR, 5.06; 95% CI, 1.06–24.32) were significantly associated with failure of histological analysis with vitrectomy cell blocks. In multivariable logistic regression analysis, similar results were obtained, although subretinal tumor infiltration was only marginally associated with the detective capability of the technique. Conclusion: Vitrectomy cell block technique significantly improved the definitive diagnosis of VRL. Concurrent cataract surgery with vitrectomy and subretinal tumor infiltration were risk factors for failure in vitrectomy cell blocks..
61. Yuka Kozuma, Gouji Toyokawa, Yuichi Yamada, Fumihiro Shoji, Koji Yamazaki, Yoshinao Oda, Sadanori Takeo, Spread through air spaces in non-small cell lung cancer, Journal of Thoracic Disease, 10.21037/jtd.2019.08.97, 2019.01.
62. Akira Miyama, Shigeyuki Kuratsu, Satoshi Takenaka, Michiko Yoshimura, Genichiro Yoneda, Yuichi Yamada, Yoshinao Oda, Two case reports of intra-articular nodular fasciitis of the knee confirmed by MYH9-USP6 gene fusion expression, Journal of Orthopaedic Science, 10.1016/j.jos.2018.12.008, 2019.01, Aim: To describe two cases of intra-articular nodular fasciitis (NF) which developed within the knee joint and were associated with the expression of the MYH9-USP6 gene fusion. Patients and methods: Two women, 30 and 56 years of age, with no history of joint disease or knee joint trauma, are presented in our cases. We report these cases describing the clinical presentation, assessment, histopathological examination, gene expression, and clinical management. Results: Both patients presented with knee pain and limitation in the range of flexion. We diagnosed our two cases as intraarticular nodular fasciitis based on histological findings and by the detection of the MYH9-USP6 gene fusion. The transcript of MYH9-USP6 gene fusion was identified by RT-PCR and direct sequencing in both cases. Conclusion: We report the first cases of intra-articular NF involving the knee joint, with identification of a MYH9-USP6 gene fusion by RT-PCR. NF should be considered in the differential diagnosis of intra-articular lesions..
63. Kenji Yorita, Yuki Togashi, Hideyuki Nakagawa, Katsushi Miyazaki, Seiji Sakata, Satoko Baba, Kengo Takeuchi, Yoshihiro Hayashi, Ichiro Murakami, Naoto Kuroda, Yoshinao Oda, Kenichi Kohashi, Yuichi Yamada, Daisuke Kiyozawa, Michael Michal, Michal Michal, Vocal cord inflammatory myofibroblastic tumor with mucoid deposits harboring TIMP3–ALK fusion
A potential diagnostic pitfall
, Pathology International, 10.1111/pin.12796, 2019.01, A 35-year-old Japanese man who had experienced hoarseness for 10 years presented with a vocal cord lesion. A gross examination revealed a left vocal cord polyp occupying two-thirds of the vocal space. The endoscopically resected lesion contained scattered atypical fibroblastic, stellate, or ganglion-like cells with mucoid stroma. Vacuolated cells were also seen. Lymphoplasmacytic infiltrate was largely undetectable. A vocal cord polyp was first suspected, but well-differentiated liposarcoma and inflammatory myofibroblastic tumor (IMT) were included in the differential diagnoses. The tumor cells were positive for anaplastic lymphoma kinase (ALK), calponin, and vimentin, and negative for other smooth muscle markers by immunohistochemistry. Structures resembling myofibroblasts were not observed by electron microscopy, which confirmed abundant rough endoplasmic reticulum in the tumor cells and accumulated lipid droplets in some tumor cells. ALK gene rearrangement was detected by fluorescence in situ hybridization, and TIMP3–ALK fusion was confirmed by 5′ rapid amplification of cDNA ends. We diagnosed the lesion as an IMT, and an ALK-rearranged stellate cell tumor may be postulated. This is the first report of a fusion partner gene of ALK in a case of laryngeal IMT..
64. Koga N, Kubo N, Saeki H, Sasaki S, Jogo T, Hirose K, Nakashima Y, Oki E, Koga Y, Oda Y, Oiwa H, Oiwa T, Maehara Y. , Primary amelanotic malignant melanoma of the esophagus: a case report., Surg Case Rep., 2019.01.
65. Ryo Yamasaki, Tomomi Yonekawa, Saeko Inamizu, Koji Shinoda, Hirofumi Ochi, Takuya Matsushita, Noriko Isobe, Gaku Tsuji, Shoko Sadashima, Yuki Kuma, Yoshinao Oda, Toru Iwaki, Masutaka Furue, Jun ichi Kira, A case of overlapping adult-onset linear scleroderma and Parry-Romberg syndrome presenting with widespread ipsilateral neurogenic involvement, Neuropathology, 10.1111/neup.12614, 2019.01, Linear scleroderma is a variant of localized scleroderma. We report a 43-year-old woman who had developed left arm weakness and linear scleroderma on her back during pregnancy at 25 years of age, followed by left hemifacial atrophy and left leg weakness. She had multiple linear scleroderma lesions on her trunk and left limbs, left eyelid ptosis, impairment of vertical movement and abduction of the left eye, left hemifacial atrophy, and weakness and atrophy of the sternocleidomastoid, trapezius, and proximal limb muscles on the left side. On serology, antibodies to U1-ribonucleoprotein and Jo-1 were positive; anti-scleroderma-70 antibody was negative. Skin biopsy demonstrated increased hypertrophic collagen fibers without inflammatory infiltrates. Needle electromyography of left limb muscles revealed mild neurogenic patterns; left quadriceps muscle biopsy showed chronic neurogenic changes. Brain magnetic resonance imaging revealed mild left hemispheric atrophy. This is a rare case of linear scleroderma and Parry–Romberg syndrome presenting with widespread ipsilateral neurogenic manifestations..
66. Kobayashi H, Kobayashi Y, Yuasa S, Okabe M, Yamada Y, Oda Y, Debiec-Rychter M, Rubin BP, Suzuki T. , A Case of Undifferentiated Sarcoma in the Superior Vena Cava and Bilateral Cervical Veins., Am J Case Rep., 2018.11.
67. Kinoshita F, Shoji F, Takada K, Toyokawa G, Okamoto T, Yano T, Oda Y, Maehara Y. , Mucinous adenocarcinoma of the thymus: report of a case.
, Gen Thorac Cardiovasc Surg. , 2018.02.
68. Kohsaka S, Saito T, Akaike K, Suehara Y, Hayashi T, Takagi T, Kaneko K, Ueno T, Kojima S, Kohashi KI, Mano H, Oda Y, Yao T. , Pediatric soft tissue tumor of the upper arm with LMNA-NTRK1 fusion.
, Hum Pathol., 72:167-173. , 2018.02.
69. Harimoto N, Yugawa K, Ikegami T, Ohira M, Mano Y, Motomura T, Toshima T, Itoh S, Harada N, Soejima Y, Yoshizumi T, Maehara Y, Oda Y. , Hepatobiliary and Pancreatic: Pregnancy induced hepatic veno-occlusive disease requiring liver transplantation.
, J Gastroenterol Hepatol. , 33(1):9., 2018.01.
70. Kuwamoto S, Matsushita M, Takeda K, Tanaka N, Endo Y, Yamasaki A, Kohashi K, Oda Y, Horie Y. , SMARCA4-deficient thoracic sarcoma: report of a case and insights into how to reach the diagnosis using limited samples and resources.
, Hum Pathol. , 70:92-97. , 2017.12.
71. Ono M, Kasuga Y, Uehara T, Oda Y. , Epithelioid hemangioendothelioma of the thyroid: a case report.
, Surg Case Rep. , 3(1):18., 2017.12.
72. Sasaki S, Sugiyama M, Nakaji Y, Nakanishi R, Nakashima Y, Saeki H, Oki E, Oda Y, Maehara Y. , Anal metastasis of rectal cancer-adenocarcinoma of squamous cells: a case report and literature review.
, Surg Case Rep. , 2017.12.
73. Shindo K, Nagai E, Nabae T, Eguchi T, Moriyama T, Ohuchida K, Manabe T, Ohtsuka T, Oda Y, Hashizume M, Nakamura M. , Successful video-assisted thoracoscopic surgery in prone position in patients with esophageal cancer and aberrant right subclavian artery: report of three cases.
, Surg Case Rep., 3(1):86. , 2017.12.
74. Yoshiya K, Imamura Y, Nakaji Y, Taniguchi D, Takeda R, Ando K, Nakashima Y, Shimizu M, Ohgaki K, Furusyo N, Matsumoto T, Saeki H, Oda Y, Oki E, Maehara Y. , Successful surgical intervention for rectal perforation due to polyarteritis nodosa
: report of a case.
, Surg Case Rep. , 3(1):43. , 2017.12.
75. Yoshiya K, Imamura Y, Nakaji Y, Taniguchi D, Takeda R, Ando K, Nakashima Y, Shimizu M, Ohgaki K, Furusyo N, Matsumoto T, Saeki H, Oda Y, Oki E, Maehara Y. , Successful surgical intervention for rectal perforation due to polyarteritis nodosa
: report of a case.
, Surg Case Rep. , 3(1):43. , 2017.12.
76. Yoshihiro T, Tsuchihashi K, Nio K, Arita S, Nakano T, Yasumatsu R, Jiroumaru R, Ariyama H, Kusaba H, Oda Y, Akashi K, Baba E. , Lingual alveolar soft part sarcoma responsive to pazopanib: A case report.
, Medicine (Baltimore)., 2017.11.
77. Ikematsu Y, Yoneshima Y, Ijichi K, Tanaka K, Harada T, Oda Y, Nakanishi Y, Okamoto I., Marked response to pembrolizumab in a patient with pulmonary pleomorphic carcinoma highly positive for PD-L1., Lung Cancer., 112:230-231, 2017.10.
78. Okumura Y, Kohashi K, Wang H, Kato M, Maehara Y, Ogawa Y, Oda Y. , Combined primary hepatic neuroendocrine carcinoma and hepatocellular carcinoma with aggressive biological behavior (adverse clinical course): A case report.
, Pathol Res Pract. , 213(10):1322-1326., 2017.10.
79. Fujimoto Y, Nakashima Y, Sasaki S, Jogo T, Hirose K, Edahiro K, Korehisa S, Taniguchi D, Kudou K, Nakaji YU, Nakanishi R, Ando K, Saeki H, Oki E, Fujiwara M, Oda Y, Maehara Y., Chemoradiotherapy for Solitary Skeletal Muscle Metastasis from Oesophageal Cancer: Case Report and Brief Literature Review.
, Anticancer Res. , 37(10):5687-5691
, 2017.10.
80. Oda Y, Yamamoto H, Kohashi K, Yamada Y, Iura K, Ishii T, Maekawa A, Bekki H., Soft tissue sarcomas: From a morphological to a molecular biological approach., Pathol Int., 67(9):435-446, 2017.09.
81. Akamine T, Toyokawa G, Kohashi K, Matsubara T, Kozuma Y, Haratake N, Takamori S, Katsura M, Takada K, Shoji F, Okamoto T, Oda Y, Maehara Y. , Highlighted version successful resection of a tracheal metastasis of rectal cancer: a case report.
, J Thorac Dis. , E797-E800. , 2017.09.
82. Tsuruta N, ,Takayoshi K, Arita S, Aikawa T , Ariyama H, Kusaba H, Ohuchida K, Nagai E, Kohashi K, Hirahashi M, Inadomi K, Tanaka M, Sagara K, Okumura Y, Nio K, Nakano M, Nakamura M, Oda Y, Akashi K, Baba E. , Systemic chemotherapy with pronounced efficacy and neutropenia in a granulocyte-colony stimulating factor-producing
advanced gastric neuroendocrine carcinoma
, Oncol Lett., 14(2):1500-1504., 2017.08.
83. Hatano T, Ohishi M, Yoshimoto G, Yamauchi M, Maekawa A, Yamamoto H, Oda Y, Endo M, Bekki H, Matsunobu T, Nakashima Y, Okazaki K, Fukushi JI, Oyamada A, Iwamoto Y. , Methotrexate-Related Lymphoproliferative Disorder Presenting with Severe Swelling of the Elbow Joint: A Case Report.
, JBJS Case Connect. , 7(3):e65. , 2017.07.
84. Nishijima T, Yamamoto H, Nakano T, Hatanaka Y, Taguchi KI, Masuda M, Oda Y., Low-grade intraductal carcinoma (low-grade cribriform cystadenocarcinoma) with tumor-associated lymphoid proliferation of parotid gland., Pathol Res Pract., 213(6):706-709., 2017.06.
85. Takizawa K, Kohashi K, Negishi T, Taguchi K, Yamada Y, Nakamura M, Oda Y. , A exceptional collision tumor of primary adrenal angiosarcoma and non-functioning adrenocortical adenoma.
, Pathol Res Pract. , 213(6):702-705., 2017.06.
86. Yoshihiro T, Nio K, Tsuchihashi K, Ariyama H, Kohashi K, Tsuruta N, Hanamura F, Inadomi K, Ito M, Sagara K, Okumura Y, Nakano M, Arita S, Kusaba H, Oda Y, Akashi K, Baba E. , Pancreatic acinar cell carcinoma presenting with panniculitis, successfully treated with FOLFIRINOX: A case report.
, Mol Clin Oncol. , 6(6):866-870. , 2017.06.
87. Aso A, Ihara E, Nakamura K, Sudovykh I, Ito T, Nakamura M, Ikeda T, Takizawa N, Oda Y, Shimizu S. , Solid Pseudopapillary Neoplasm of the Pancreas in Young Male Patients: Three Case Reports.
, Case Rep Gastrointest Med. , 2017.05.
88. Ogata H, Yamamoto Y, Harada T, Nakanishi Y, Okamoto I, Iwama E, Kato K, Oda Y., Severe Aplastic Anemia during Osimertinib Therapy in a Patient with EGFR Tyrosine Kinase Inhibitor-Resistant Non-Small Cell Lung Cancer.
, J Thorac Oncol. , 12(5):e46-e47., 2017.05.
89. Tsuchihashi K, Kusaba H, Yamada Y, Okumura Y, Shimokawa H, Komoda M, Uchino K, Yoshihiro T, Tsuruta N, Hanamura F, Inadomi K, Ito M, Sagara K, Nakano M, Nio K, Arita S, Ariyama H, Kohashi K, Tominaga R, Oda Y, Akashi K, Baba E , Programmed death-ligand 1 expression is associated with fibrosarcomatous transformation of dermatofibrosarcoma protuberans
, Mol Clin Oncol. , 6(5):665-668. , 2017.05.
90. Kohashi K, Oda Y., Oncogenic roles of SMARCB1/INI1 and its deficient tumors., Cancer Sci., 108(4):547-552, 2017.04.
91. Adachi K, Umezaki T, Nishijima T, Yamamoto H, Oda Y., Long-term outcomes of type I thyroplasty with silicone implantation: Assessment of excised laryngeal tissue from a patient with secondary hypopharyngeal carcinoma.
, Auris Nasus Larynx., 44(2):245-248., 2017.04.
92. Shinichi Aishima, Yoshinao Oda, Pathogenesis and classification of intrahepatic cholangiocarcinoma: different characters of perihilar large duct type versus peripheral small duct type., J Hepatobiliary Pancreat Sci. 2015 Feb;22(2):94-100., 2015.02.
93. Hidetaka Yamamoto, Yoshinao Oda, Gastrointestinal stromal tumor: Recent advances in pathology and genetics., Pathol Int Jan 65: 9–18, 2015, 2015.01.
94. Hidetaka Yamamoto, Yoshinao Oda, 胃腸管間質腫瘍(GIST)の遺伝子異常に基づく亜型分類と臨床的意義, 福岡医学雑誌 105 (8): 157-165, 2014, 2014.08.
95. Kataoka K, Tanaka K, Mizusawa J, Kimura A, Hiraga H, Kawai A, Tomoya Matsunobu, Matsumine A, Araki N, Yoshinao Oda, Fukuda H, Yukihide Iwamoto, Tissue Tumor Study Group of the Japan Clinical Oncology Group:
A randomized phase II/III trial of perioperative chemotherapy with adriamycin plus ifosfamide vs. gemcitabine plus docetaxel for high-grade soft tissue sarcoma: Japan Clinical Oncology Group study JCOG1306.
, Jpn J Clin Oncol. 2014 Aug;44(8):765-9., 2014.08.
96. Yoshitane Tsukamoto, Takahiro Watanabe, Soh Nishimoto, Masao Kakibuchi, Yuichi Yamada, Kenichi Kohashi, Yoshinao Oda, Seiichi Horita, STAT6-positive intraorbital papillary tumor: A rare variant of solitary fibrous tumor?, Pathol Res Pract. 2014 Jul;210(7):450-3., 2014.07.
97. Shohei Yoshiya, ikegami Toru, Tomoharu Yoshizumi, Huanlin Wang, Noboru Harada, Yo-ichi Yamashita, Akihiro Nishie, Ken Shirabe, Yoshinao Oda, Yoshihiko Maehara, Fairly rare de Novo inflammatory pseudotumor in a graft after living donor liver transplantation., Liver Transpl, 2014 May;20(5):616-8. , 2014.05.
98. Yasunori Sakai, Ryota Souzaki, Hidetaka Yamamoto, Yuki Matsushita, Hazumu Nagata, Ishizaki Yoshito, Hiroyuki Torisu, Yoshinao Oda, tomoaki taguchi, Chad A Shaw, Toshiro Hara, Testicular sex cord-stromal tumor in a boy with 2q37 deletion syndrome., BMC Med Genomics. 2014 Apr 22;7(1):19., 2014.04.
99. Yuka Hotokebuchi, Kenichi Kohashi, Satoshi Toyoshima, Naoko Matsumoto, Toshinori Nakashima, Yoshinao Oda, Congenital peribronchial myofibroblastic tumor., Pathol Int. 2014 Apr;64(4):189-91., 2014.04.
100. Takamichi Ito, Itoh Eriko, Ayami Koda-Maeda, Hiroaro Kiryu, Yuichi Yamada, Toshiharu Yamashita, Yoshinao Oda, Masutaka Furue, Lipoblastomatosis on the sole showing spontaneous regression., 2014.04.
101. Yusuke Inatomi, Takamichi Ito, Konosuke Nagae, Yuichi Yamada, Mari Kiyomatsu, Nakano Misa, Uchi Hiroshi, Yoshinao Oda, Masutaka Furue, Hybrid perineurioma-neurofibroma in a patient with neurofibromatosis type 1, clinically mimicking malignant peripheral nerve sheath tumor., 2014.04.
102. Harimoto Norifumi, ikegami Toru, H Nakagawara, Yo-ichi Yamashita, Tomoharu Yoshizumi, Hideaki Uchiyama, T Soejima, K Ikeda, Ken Shirabe, Shinichi Aishima, Yoshinao Oda, Yoshihiko Maehara, Chronic Immune-Mediated Reaction Syndrome as the Cause of Late Graft Mortality in Living-Donor Liver Transplantation for Primary Biliary Cirrhosis., Transplant Proc. 2014 May 14, 2014.04.
103. Yuusuke Mizuuchi, Shinichi Aishima, Masami Hattori, Yasuhiro Ushijima, Akira Aso, Shunichi Takahata, Ohtsuka Takao, JUNJI UEDA, Masao Tanaka, Yoshinao Oda, Follicular pancreatitis mimicking pancreatic cancer, report of a case and review of the literature., Pathol Res Pract. 2014 Feb;210(2):118-22. (corresponding), 2014.02.
104. Yoshihiro Matsumoto, Yusuke Takahashi, Akihisa Haraguchi, Tatsuro Okamoto, Katsumi Harimaya, Tomoya Matsunobu, Makoto Endo, Yoshinao Oda, Yukihide Iwamoto, Intraosseous hemangioma arising in the clavicle., Skeletal Radiol. 2014 Jan;43(1):89-93., 2014.01.
105. Shinichi Aishima, Yuichiro Kubo, Yuki Tanaka, Yoshinao Oda, Histological features of precancerous and early cancerous lesions of biliary tract carcinoma., Journal of Hepato-Biliary-Pancreatic Sciences, 2014 Jan 21, 2014.01.
106. Makoto Endo, Hidetaka Yamamoto, Katsumi Harimaya, Kenichi Kohashi, Takeaki Ishii, N Setsu, Yukihide Iwamoto, Yoshinao Oda, Conventional spindle cell type malignant peripheral nerve sheath tumor arising in a sporadic schwannoma., Hum Pathol. 2013 Dec;44(12):2845-8. (corresponding) , 2013.12.
107. Makoto Endo, Kenichi Kohashi, Hidetaka Yamamoto, Takeaki Ishii, Tatsuya Yoshida, Tomoya Matsunobu, Yukihide Iwamoto, Yoshinao Oda, Ossifying fibromyxoid tumor presenting EP400-PHF1 fusion gene.
, Hum Pathol Nov;44(11):2603-2608, 2013 (corresponding), 2013.11.
108. Koji Shindo, JUNJI UEDA, Shinichi Aishima, Akira Aso, Ohtsuka Takao, Shunichi Takahata, Kousei Ishigami, Yoshinao Oda, Masao Tanaka, Small-sized, flat-type invasive branch duct intraductal papillary mucinous neoplasm: a case report., 2013.10.
109. Shinji Okano, Hidetaka Yamamoto, Shinji Kono, Hiroshi Fujii, Ken Shirabe, Yoshihiko Maehara, Yoshinao Oda, Dedifferentiated liposarcoma of a spermatic cord with a hemangioendothelioma-like component: A case report and review of the literature., Pathol Res Pract Sep;209(9):596-604, 2013 , 2013.09.
110. Yusuke Mizuuchi, Hidetaka Yamamoto, Katsuya Nakamura, Shirahane Kengo, Masae Souzaki, Masao Tanaka, Yoshinao Oda, Solitary fibrous tumor of the thyroid gland., 2013.09.
111. SATOSHI YAMASAKI, Tsuyoshi Muta, Taiki Higo, Hirotake Kusumoto, Eiko Zaitsu, Toshihiro Miyamoto, Yoshinao Oda, koichi akashi, Ventricular fibrillation after bortezomib therapy in a patient with systemic amyloidosis., Hematol Rep. 2013 Sep 16;5(3):e12. doi: 10.4081/hr.2013.e12., 2013.09.
112. Koji Tamura, Ohtsuka Takao, Noboru Ideno, Teppei Aso, Hiroshi Kono, Yousuke Nagayoshi, Koji Shindo, Yasuhiro Ushijima, JUNJI UEDA, Shunichi Takahata, Tetsuhide Ito, Yoshinao Oda, Mizumoto Kazuhiro, Masao Tanaka, Unresectable Pancreatic Ductal Adenocarcinoma in the Remnant Pancreas Diagnosed during Every-6-Month Surveillance after Resection of Branch Duct Intraductal Papillary Mucinous Neoplasm: A Case Report., J Pancreas. 2013 Jul 10;14(4):450-453. doi: 10.6092/1590-8577/1494. , 2013.07.
113. Masaki Fujioka, kenji Hayashida, Chikako Murakami, Masanori Hisaoka, Yoshinao Oda, Masahiro Ito, Cutaneous malignant rhabdoid tumor in the palm of an adult., Rare Tumors 2013-07-12 17:44:12 | DOI: 10.4081/rt.2013.e36 | , 2013.07.
114. Makoto Endo, Tatsuya Yoshida, Hidetaka Yamamoto, Takeaki Ishii, Nokitaka Setsu, Kenichi Kohashi, Tomoya Matsunobu, Yukihide Iwamoto, Yoshinao Oda, Low-grade osteosarcoma arising from bone infarct.
, Hum Pathol Jun;44(6):1184-1189,2013(corresponding), 2013.06.
115. Koji Shindo, JUNJI UEDA, Taro Toubo, Masafumi Nakamura, Yoshinao Oda, Toru Eguchi, Masao Tanaka, Primary carcinoid tumor in a retroperitoneal mature teratoma: report of a case.

, Surg Today. 2013 Jun;43(6):694-7., 2013.06.
116. Tsuyoshi Miyazaki, Kenzo Uchida, Takafumi Yayama, Hideaki Nakajima, Kazuya Honjoh, Hiroshi Ito, Yoshinao Oda, Hisatoshi Baba, Chondroblastoma of the distal femur resected through a small fenestra via computed tomography navigation and endoscopy: a case report., J Med Case Rep. 2013 Jun 27;7(1):164. , 2013.06.
117. H Tsubouchi, Shunsuke Endo, Yoshinao Oda, Yoh Dobashi, Carcinoid tumor of the lung with massive ossification: report of a case showing the evidence of osteomimicry and review of the literature
, Int J Clin Exp Pathol Apr 15;6(5):957-61, 2013, 2013.05.
118. Yusuke Takahashi, Yoshinao Oda, Hidetaka Yamamoto, Takeaki Ishii, Nokitaka Setsu, Makoto Endo, Shuichi Matsuda, Yukihide Iwamoto, Fibrocartilaginous mesenchymoma arising in the pubic bone: A case report

, Pathol Int 63(4): 226-229, 2013 (corresponding) , 2013.04.
119. Yoshihiro Matsumoto, Yusuke Takahashi, Katsumi Harimaya, NAKAGAWA Takeshi, Kenichi Kawaguchi, Seiji Okada, Hayashida Mitsumasa, Toshio Doi, Akio Sakamoto, Tomoya Matsunobu, Yoshinao Oda, Yukihide Iwamoto, Dedifferentiated chondrosarcoma of the cervical spine: a case report.
, World J Surg Oncol. Feb 2;11(1):32, 2013. , 2013.02.
120. N Watanabe, Katsunori Nenohi, Keisuke Takeuchi, Hiroshi Hasegawa, Tsuyoshi Tanaka, Makoto Shimomura, Kanji Tanigawa, Hajime Yokoi, Hiroshi Nakabayashi, Yoshinao Oda, A case of duodenal epithelioid hemangioma causing gastrointestinal bleeding.
, Nihon Shokakibyo Gakkai Zasshi. 2012;109(12):2058-65., 2012.12.
121. Akio Sakamoto, Takeaki Ishii, Yoshinao Oda, Yukihide Iwamoto, Nonossifying fibroma presenting as an aneurysmal bone cyst: a case report, J Med Case Rep. 2012 Nov 29;6(1):407. , 2012.11.
122. Akio Sakamoto, Yoshiaki Fukutoku, Yoshihiro Matsumoto, Katsumi Harimaya, Yoshinao Oda, Yukihide Iwamoto, Myxoid liposarcoma with negative features on bone scan and [18F]-2-fluoro-2-deoxy-D-glucose-positron emission tomography., World J Surg Oncol. 2012 Oct 9;10(1):214., 2012.10.
123. Kohashi K, Takahashi Y, Taguchi T, Oda Y, Pediatric Rhabdomyosarcoma: Role of Cell Cycle Regulators Alteration
M.A. Hayat (ed.), Teratoid/Rhabdoid, Brain Tumors, and Glioma, Pediatric Cancer 2,
, © Springer 2012, in press (Corresponding) , 2012.05.
124. Matsumoto Y, Fujiwara T, Imamura R, Okada Y, Harimaya K, Doi T , Kawaguchi K, Okada S, Yamada Y, Oda Y, Iwamoto Y, Hematoma of the ligamentum flavum in the thoracic spine: report of two cases and possible role of the transforming growth factor beta-vascular endothelial growth factor
signaling axis in its pathogenesis.

, J Orthop Sci, in press, 2012.05.
125. Ishii T, Sakamoto A, Matsuda S, Matsumoto Y, Harimaya K, Takahashi Y, Oda Y, Iwamoto Y, Leiomyosarcoma in the humerus with leukocytosis and elevation of serum G-CSF.
, Skeletal Radiol. 2011 Dec 14. [Epub ahead of print], in press, 2012.05.
126. Anami A, Fukushima K, Fujita Y, Sato S, Matsumoto E, Endo M, Oda Y, Wake N, An antenatally diagnosed congenital orbital teratoma in which rupture was associated with intrauterine fetal death – a case report.
, J Obstet Gynaecol Res Mar;38(3):578-81, 2012, 2012.03.
127. Yamada Y, Yamamoto H, Ohishi Y, Nishiyama K, Fukuhara M, Saitou T, Tsuneyoshi M, Oda Y, Sclerosing variant of perivascular epithelioid cell tumor in the female genital organs.
, Pathol Int 61(12) Dec; 768–772, 2011, 2011.12.
128. Mano Y, Aishima S, Fujita N, Taketomi A, Shirabe K, Maehara Y, Oda Y, Cystic tumors of the liver; on the problems of diagnostic criteria.
, Pathol Res Pract Oct 15;207(10):659-63, 2011, 2011.10.
129. Kubota K, Okada S, Maeda T, Matsumoto Y, Sakamoto A, Harimaya K, Saiwai H, Kumamaru H, Oda Y, Iwamoto Y, Extradural nodular fasciitis arising in the spinal canal.
, Spine, in press, 2011.03.
130. Sakamoto A, Imamura S, Matsumoto Y, Harimaya K, Mastuda S, Takahashi Y, Oda Y, Iwamoto Y, Bizarre parosteal osteochondromatous proliferation with an inversion of chromosome 7
, Skeletal Radiol, in press, 2011.03.
131. Souzaki R, Kinoshita Y, Matsuura T, Tajiri T, Taguchi T, Ieiri S, Hong J, Uemura M, Konishi K, Tomikawa M, Tanoue K, Hashizume M, Koga Y, Suminoe A, Hara T, Kohashi K, Oda Y, Successful resection of an undifferentiated sarcoma in a child using a real-time. Surgical navigation system in an open magnetic resonance imaging operation room.
, J Periatr Surg 46(3): 608-611, 2011, 2011.03.
132. Hashimoto K, Yamamoto H, Nakano T, Oyama M, Shiratsuchi H, Nakashima T, Tamiya S, Komune S, Oda Y, Tumor-to-tumor metastasis: Lung adenocarcinoma metastatic to follicular variant of papillary thyroid carcinoma-Report of a case with pathological, immunohistochemical and molecular analyses of the different tumor cell populations.
, Pathol Int, in press, 2011.03.
133. Yamamoto Y; Toyozawa S; Uede K; Oda Y, Nakamura Y; Furukawa F, Clinical and pathological changes in a long-term follow-up case of
dermatofibrosarcoma protuberans.
, J Dermatol 38(2); 203-205, 2011, 2011.02.
134. Yokouchi Y,Hiruta N, Oharaseki T, Ihara F, Oda Y, Ito S, Yamashita H, Ozaki S, Gomi T, Takahashi K, Primary cardiac synovial sarcoma: A case report and literature review
, Pathol Int 61(1): 150-155, 2011, 2011.01.
135. Tajiri T, Souzaki R, Kinoshita Y, Tanaka S, Koga Y, Suminoe A, Hara T, Kohashi K, Oda Y, Masumoto K, Ohira M, Nakagawara A, Taguchi T, Concordance for neuroblastoma in monozygotic twins: case report and review of the literature.
, J Pediatr Surg 45(12): 2312-6, 2010, 2010.12.
136. Ogino T, Ueda J, Sato N, Takahata S, Mizumoto K, Nakamura M, Oda Y, Tanaka M, Repeated pancreatectomy for recurrent pancreatic carcinoma after pylorus-preserving pancreatoduodenectomy: Report of two patients.
, Case Rep Gastroenterol. 2010 Oct 9;4(3):429-434, 2010.10.
137. Souzaki R, Tajiri T, Kinoshita Y, Tanaka S, Koga Y, Suminoe A, Hara T, Kohashi K, Oda Y, Taguchi T, Successful treatment of advanced pancreatoblastoma by a pylorus-preserving pancreatoduodenectomy after radiation and high-dose chemotherapy.
, Pediatr Surg Int. 26(10): 1045-1048, 2010 , 2010.10.
138. Yamamoto H, Miyamoto Y, Nishihara Y, Kojima A, Imamura M, Kishikawa K, Takase Y, Ario K, Oda Y, Tsuneyoshi M, Primary gastrointestinal stromal tumor of the liver with PDGFRA gene mutation: A case report with a review of literature.
, Hum Pathol 41(4): 605-609, 2010, 2010.04.
139. Endo M, Oda Y, Harimaya K, Tamiya S, Yamamaoto H, Kohashi K, Kurihara S, Setsu N, Matsuura S, Matono H, Matsuda S, Iwamoto Y, Tsuneysohi M: , Low-grade dedifferentiated liposarcoma of the neck: magnetic resonance imaging and pathological correlation.
, J Orthop Sci 15(1): 148-152, 2010 (Corresponding), 2010.01.
140. Kohashi K, Oda Y, Tsuneyoshi M, Direct evidence of mutational inactivation of SMARCB1/INI1 in epithelioid sarcoma-Reply.
, Hum Pathol 40(9): 1362-1364, 2009, 2009.09.
141. Koga Y, Matsuzaki A, Suminoe A, Hatano, M, Saito Y, Kinoshita Y, Tajiri T, Taguchi T, Kohashi K, Oda Y, Tsuneyoshi T, Hara T: , Long-term survival after autologous peripheral blood stem cell transplantation in two patients with malignant rhabdoid tumor of the kidney.
, Pediatr Blood Cancer 52(7): 888-890, 2009., 2009.07.
142. Oshiro Y, Kohashi K, Oda Y, Tsuneyoshi M, Shono Y , Unclassified epithelioid vascular tumor with hemangioendotheliomatous feature and lymphatic differentiation: A case report.
, Pathol Int 59(6): 410-414, 2009, 2009.06.
143. Nakamura T, Matsumine A, Kato H, Kusuzaki K, Nishimura K, Murata T, Shiraishi T, Oda Y, Tsuneyoshi M, Uchida A, Malignant melanoma with a rhabdoid phenotype exhibiting numerous solid tumor masses; A case report.
, Oncol Rep 21(4): 887-891, 2009., 2009.04.
144. Oda Y, Tsuneyoshi M , Recent advances of molecular pathology in soft tissue sarcoma: Their implications for diagnosis, patient’s prognosis, and molecular target therapy in the future
, Cancer Sci 100(2): 200-208, 2009 (Corresponding), 2009.02.
145. Kohashi K, Nakamori M, Oda Y, Yamamoto H, Tamiya S, Kurihara S, Tobo T, Kinoshita Y, Tajiri T, Taguchi T, Tsuneyoshi M: , Multifocal metanephric adenoma in childhood: A case report.
, Pathol Int 59(1): 49-52, 2009. (Corresponding), 2009.01.
146. Saito Y, Matsuzaki A, Suminoe A, Koga Y, Kurata H, Oda Y, Tsuneyoshi M, Hara T , Congenital Ewing sarcoma in retroperitoneum with multiple metastases.
, Pediatr Blood Cancer 51(5): 698-701, 2008, 2008.11.
147. Takayama Y, Yabuuchi H, Matsuo Y, Soeda H, Okafuji T, Kamitani T, Kinoshita Y, Kubokura N, Sakai S, Oda Y, Hatakenaka M, Honda H: , Computed tomographic and magnetic resonance features of inflammatory myofi broblastic tumor of the lung in children
, Radiat Med 26(10): 613-617, 2008, 2008.10.
148. Takahara M, Ichikawa R, Oda Y, Uchi H, Takeuchi S, Moroi Y, Kiryu H, Furue M, Desmoplastic fibroblastoma; a case presenting as a protruding nodule in the dermis.
, J Cutan Pathol Suppl. 1(10): 70-73, 2008, 2008.10.
149. Oda Y, Tsuneyoshi M , Expression of multidrug resistance-related molecules and Y-box-binding protein-1 in soft-tissue sarcomas.
, Nova Scientific Publisher (Corresponding), 2008.10.
150. Matsumoto Y, Matsuda S, Matono K, Oda Y, Tsuneyoshi M, Iwamoto Y , Intra-articular osteochondroma of the knee joint in a patient with hereditary multiple osteochondromatosis.
, Fukuoka Acta Med 98(12): 425-430, 2007., 2007.12.
151. Oda Y, Takahira T, Yokoyama R, Tsuneyoshi M, Diffuse-type giant cell tumor (GCT)/ pigmented villonodular synovitis (PVNS) arising in the sacrum: Malignant form.
, Pathol Int 57(9): 627-631, 2007 (Corresponding), 2007.09.
152. Sakamoto A, Yoshida T, Matono H, Tanaka K, Matsuda S, Oda Y, Iwamoto Y, Dedifferentiated liposarcoma with leukocytosis. A case report. G-CSF-producing soft-tissue tumors, possible association with undifferentiated liposarcoma lineage.
, World J Surg Oncol, 5(1): 131 (5 pages), 2007 (Online journal), 2007.08.
153. Ishimura M, Ohga S, Nagatoshi Y, Okamura J, Tajiri T, Kohashi K, Oda Y, Takada H, Hara T , Malignant hepatic tumor occurring 10 yrs after a histocompatible sibling donor bone marrow transplantation for severe aplastic anemia.
, Pediatr Transplant 11(8):945-949, 2007, 2007.08.
154. Sakamoto A, Yoshida T, Matsuura S, Tanaka K, Matsuda S, Oda Y, Hori Y, Yokomizo A, Iwamoto Y, Metastasis to the gluteus muscle from renal cell carcinoma with special emphasis on MRI features
, World J Surg Oncol 5: 88 (4pages), 2007 (Online journal), 2007.06.
155. Yoshida T, Sakamoto A, Tanaka K, Matsuda S, Oda Y, IwamotoY , Alternative surgical treatment for giant-cell reparative granuloma in the metacarpal bone of the hand, ulilizing phenol and ethanol adjuvant therapy.
, J Hand Surg (Am) 32 (6): 887-892, 2007 , 2007.06.
156. Sakamoto A, Yamamoto H, Yoshida T, Tanaka K, Matsuda S, Oda Y, Tsuneyoshi M, Iwamoto Y, Desmoplastic fibroblastoma (collagenous fibroma) with a specific breakpoint of 11q12., Histopathology 51(6), 859-860, 2007, 2007.06.
157. Kinoshita Y, Tajiri T, Ieiri S, Nagata K, Taguchi T, Suita S, Yamazaki K, Yoshino I, Maehara Y, Kohashi K, Yamamoto H, Oda Y, Tsuneyoshi M, A case of an inflammatory myofibroblastic tumor in the lung which expressed TPM3-ALK gene fusion., Pediatr Surg Int 23(6): 595-599, 2007, 2007.06.
158. Miyajima K, Hasegawa S, Oda Y, Toyoshima S, Tsuneyoshi M, Motooka M, Matsuura Y, Ishioka H, Ono M: , Angiomyofibroblastoma-like tumor (cellular angiofibroma) in the male inguinal region.
, Radiat Med 25(4): 173-177, 2007, 2007.04.
159. Sakamoto A, Yoshida T, Yamamoto H, Oda Y, Tsuneyoshi M, Iwamoto Y , Congenital pseudoarthrosis of the tibia. An analysis of the histology and NF1 gene: Case study.
, J Orthop Sci 12(4): 361-365, 2007, 2007.04.
160. Yoshida T, Sakamoto A, Tanaka K, Iwamoto Y, Oda Y, Izumi T, Tsuneyoshi M, Intramuscular diffuse-type giant cell tumor within hamstring muscle., Skeletal Radiol 36; 331-333, 2007., 2007.03.
161. Sakamoto A, Tanaka K, Matsuda S, Oda Y, Tsuneyoshi M, Iwamoto Y, Aneurysmal bone cyst of the capitate: a case report and a review emphasizing local recurrence., Fukuoka Acta Med 97:302-7, 2006., 2006.01.
162. Sakamoto A, Tanaka K, Matsuda S, Harimaya K, Nakamura T, Oda Y, Tsuneyoshi M, Iwamoto Y, Adventitial cystic disease of the popliteal vein: report of a case., Surg Today 12: 1098-100, 2006., 2006.01.
163. Sakamoto A, Yoshida T, Matsuda S, Tanaka K, Kobayashi C, Oda Y, Tsuneyoshi M, Iwamoto Y, Chondromyxoid fibroma of the clavicle., J Orthop Sci 11; 533-536, 2006., 2006.01.
164. Sakamoto A, Yamamoto H, Tanaka K, Matsuda S, Harimaya K, Oda Y, Tsuneyoshi M, Iwamoto Y, Dedifferentiated chondrosarcoma with leukocytosis and elevation of serum G-CSF. A case report., World J Surg Oncol 4; 37 (7 pages): 2006. (Online journal), 2006.01.
165. Matsuo Y, Sakai S, Yabuuchi H, Soeda H, Takahashi N, Okafuji T, Yoshimitsu K, Koga H, Yoshino I, Oda Y, Nakamura Y, Honda H., A case of pulmonary synovial sarcoma diagnosed with detection of chimera gene. Imaging findings., Clin Imaging 30: 60-2, 2006, 2006.01.
166. Yamamoto H, Oda Y, Yao T, Oiwa T, Kobayashi C, Tamiya S, Kawaguchi K, Hino O, Tsuneyoshi M, Malignant perivascular epithelioid cell tumor of the colon: Report of a case with molecular analysis., Pathol Int 56: 46-50, 2006, 2006.01.
167. Oda Y, Tsuneyoshi M, Letter to the editor; Re: Oda et al. Frequent alteration of p16INK4a/p14ARF and p53 pathways in the round cell component of myxoid/round cell liposarcoma: p53gene alterations and reduced p14ARF expression both correlate with poor prognosis. Author's reply, J Pathol 209: 282, 2006., 2006.01.
168. Ohishi Y, Kaneki E, Tamiya S, Oda Y, Hirakawa T, Miyamoto S, Kaku T, Nakano H, Tsuneyoshi M, Role of immunohistochemical expression of Ki-67 in ovarian carcinoma., Handbook of Immunohistochemistry and in situ Hybridization of Human Carcinomas, Hayat MA (Edt), Volume 4: Molecular Genetics,Gastrointestinal Carcinoma, and Ovarian Carcinoma, Elsevier Academic Press, London, 2006, pp363-370., 2006.01.
169. Shimonodan H, Nagayama J, Nagatoshi Y, Hatanaka M, Takada A, Iguchi H, Oda Y, Okamura J, Acute lymphocytic leukemia in adolescence with multiple osteolytic lesion and hypercalcemia mediated by lymphoblast-producing parathyroid hormone-related peptide: A case report and review of the literature., Pediatric Blood and Cancer 45: 333-339, 2005, 2005.01.
170. Saito T, Oda Y , Kawaguchi K, Tanaka K, Matsuda S, Sakamoto A, Iwamoto Y, Tsuneyoshi M, Five-year evoluation of a telangiectatic osteosarcoma initially managed as an aneurysmal bone cyst., Skeletal Radiol 34: 290-294, 2005., 2005.01.
171. Kiyoshima K, Oda Y, Nakamura T, Migita T, Okumura K, Naito S, Tsuneyoshi M:, Multicentric papillary renal cell carcinoma associated with renal adenomatosis., Pathol Int 54: 266-272, 2004., 2004.06.
172. Niwa H, Masuda S, Kobayashi C, Oda Y, Pulmonary synovial sarcoma with polypoid endobronchial growth: A case report, immunohistochemical and cytogenetic study., Pathol Int 54: 611-615, 2004., 2004.01.
173. Harimaya K, Oda Y, Matsuda S, Tanaka K, Sakamoto A, Chuman K, Iwamoto Y:, Primitive neuroectodermal tumor and extraskeletal Ewing's sarcoma arising primarily around the spinal colum: report of four cases and review of the literature., Spine 28: E408-412, 2003., 2003.01.
174. Yamaguchi M, Yoshino I, Osoegawa A, Kameyama T, Tagawa T, Fukuyama S, A, Kameyama T, Tagawa T, Fukuyama S,, Inflammatory myofibroblastic tumor of the mediastinum presenting as superior vena cava syndrome., J Thorac Cardiovasc Surg 26; 870-872, 2003., 2003.01.
175. Yamamoto H, Shiratsuchi H, Yao T, Uryu H, Oda Y, Tamiya S, Tsuneyoshi M:, ALK-positive anaplastic large cell lymphoma of the parotid gland., Histopathology 43: 397-398, 2003., 2003.01.
176. Saito T, Oda Y, Tanaka K, Matsuda S, Sakamoto A, Yamamoto H , Iwamoto Y, Tsuneyoshi M:, Low-grade fibrosarcoma of the proximal humerus. A case report with a review of literatures., Pathol Int 53: 115-120, 2003., 2003.01.
177. Kikuchi I, Anbo J, Nakamura S, Sugai T, Sasou S, Yamamoto M, Oda Y, Shiratsuchi H, Tsuneyoshi M:, Synovial sarcoma of the thyroid: Report of a case with aspiration cytology findings and gene analysis., Acta Cytologica 47: 495-500, 2003., 2003.01.
178. Adachi T, Oda Y, Sakamoto A, Saito T, Tamiya S, Hachitanda Y, Masuda S, Tsuneyoshi M, Mixed tumor of deep soft tissue, Pathol Int 53: 35-39, 2003., 2003.01.
179. 小田義直, 巨細胞性線維芽細胞腫の病態, 日本医事新報 第4146号: 98-99, 2003, 2003.01.
180. Ehara S, Oda Y:, Letter to the Editor; Infantile fibromatosis., Am J Roentgenol 180; 284, 2003., 2003.01.
181. Kawaguchi K, Oda Y, Nakanishi K, Saito T, Tamiya S, Nakahara K, Matsuoka H, Tsuneyoshi M, Malignant transformation of renal angiomyolipoma: A case report., Am J Surg Pathol 26: 523-529, 2002., 2002.01.
182. Ehara S, Oda Y, Letter to the Editor; Deep dermatofibrosarcoma protuberans., Am J Roentgenol 179; 1643, 2002. , 2002.01.
183. Oda Y, Tsuneyoshi M, Letter to the Editor; Leiomyosarcoma versus myofibrosarcoma. Author's reply, Am J Surg Pathol 26; 394-396, 2002, 2002.01.
184. Sakamoto A, Oda Y, Nagayoshi Y, Iwakiri K, Tamiya S, Iwamoto Y, Tsuneyoshi M, Glomangiopericytoma causing oncologic osteomalacia. A case report with immunohistochemical analysis., Arch Orthop Trauma Surg 121: 104-108, 2001, 2001.01.
185. Oda Y, Kinoshita Y, Tamiya S, Iwamoto Y, Tsuneyoshi M:, Extraskeletal primitive neuroectodermal tumor with massive osteo-cartilaginous metaplasia., Histopathology 36: 188-191, 2000, 2000.01.
186. Kitamura T, Oda Y, Matsuda S, Kubota H, Iwamoto Y:, Nerve sheath ganglion of the ulnar nerve., Arch Orthop Trauma Surg 120: 108-109, 2000, 2000.01.
187. Saito T, Terada K, Tsuchiya K, Oda Y, Tsuneyoshi M, Iwamoto Y, Lymphangioma presenting as a dumbell tumor in the epidural space of the lumbar spine., Spine 24: 74-76, 1999, 1999.01.
188. Kawaguchi K, Oda Y, Miura H, Watanabe T, Tsuneyoshi M, Iwamoto Y:, Periostel osteoblastoma of the distal humerus. A case report., J Orthop Science 3: 341-345, 1998, 1998.01.
189. Y Okumura, M Komoda, S Tamura, H Kumagai, T Shirakawa, Shuji Arita, Ariyama Hiroshi, hitoshi kusaba, UMENO JUNJI, Matsumoto Takuya, Hidetaka Yamamoto, Yoshinao Oda, koichi akashi, Eishi Baba, Anti-HER2 combinationchemotherapy for advanced gastric cancer associated with the Peutz-Jeghers syndrome: a case report and literature review., Int Cancer Conf J, in press .
190. Kenzo Sonoda, M Nogami, M Naka, F Ookubo, H Kobayashi, Hideaki Yahata, Okugawa Kaoru, Kaneki Eisuke, Yoshinao Oda, Kiyoko Kato, Charactetristic cytological features of cervical clear cell adenocarcinoma: A report of 4 cases., J Cytol Histol 4:5, 2013.