九州大学 研究者情報
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基本情報 研究活動 教育活動 社会活動
大嶋 雄治(おおしま ゆうじ) データ更新日:2020.06.12

教授 /  農学研究院 資源生物科学部門 動物・海洋生物資源学


主な研究テーマ
水生生物におけるマイクロプラスチックの影響
キーワード:マイクロプラスチック 水生生物
2016.04.
水生生物における異物結合排泄タンパク質(トリブチルスズ結合タンパク質)の研究
キーワード:リポカリン 異物
2002.04.
タイラギ貝のmRNA-Seqによる大量へい死の原因解明
キーワード:mRNA-Seq タイラギ貝 大量へい死
2000.04.
化学物質が魚の発音行動に及ぼす影響
キーワード:化学物質 魚類 行動影響 リスク
2000.04.
トリブチルスズとPCBsの複合作用に関する研究
キーワード:トリブチルスズ PCBs 複合毒性
1997.04.
トリブチルスズによる汚染とその水産生物に対する影響
キーワード:トリブチルスズ 汚染 影響
1996.04~2003.01.
水生生物における内分泌攪乱
キーワード:メダカ 環境ホルモン リスク
1996.04.
水産用医薬品の体内動態
キーワード:体内動態
1994.04~2003.01.
すり身加工技術を用いた食品中からのPCBsの除去
キーワード:食の安全
2001.04.
従事しているプロジェクト研究
マイクロプラスチックの水生生物への影響
2017.06~2020.06, 代表者:大嶋雄治.
魚類の低分子結合性タンパク質ーリポカリンの大量発現と静菌活性に関する研究 
2008.05~2010.03, 代表者:大嶋雄治, 九州大学, 九州大学(日本).
有明海における貝類の激減と環境汚染物質に関する研究
2005.05~2016.03, 代表者:大嶋雄治, 九州大学, 九州大学(日本).
化学物質の肥満活性に関する研究
2013.04~2018.01, 代表者:大嶋雄治, 九州大学(日本)
メダカを用いて化学物質の肥満活性の複合作用を評価する.
研究業績
主要著書
1. 大嶋雄治, 重金属、内分泌かく乱物質, 水産利用化学の基礎, 恒星社厚生閣, 157-161, 2010.04.
2. Oshima Y, Nakayama K, Hano T, Kim SG, Shimasaki Y, Kang IJ, Honjo T. , Toxic Interactions Between Tributyltin and Polychlorinated Biphenyls in Aquatic Organisms Ed T. Arai et al (eds.), In”Environmental Impact of Antifouling Biocides” () , Springer, 195-205, 2009.04.
3. 大嶋雄治・島崎洋平・本城凡夫, トリブチルスズの魚類血液へ蓄積と次世代への影響(オス化), 有機スズ汚染と水生生物影響—進展する研究の成果—,山田編,, 恒星社厚生閣, pp231-238, 2007.04.
4. 大嶋雄治, 仲山 慶, Kang, I. J., 島崎洋平,本城凡夫, 生態リスク評価と行動影響評価 化学物質の生態リスク評価と規制ー農薬編ー, 監修 日本環境毒性学会, 編著者 畠山成久 . 2006, 東京, , アイピーシー, pp167-172, 2006.01.
5. 大嶋雄治, 高次バイオマーカーによる魚類の慢性影響評価, 化学物質の生態リスク評価と規制ー農薬編ー, 監修 日本環境毒性学会, 編著者 畠山成久, アイピーシー, pp253-258, 2006.01.
6. 大嶋雄治, 水産学辞典 薬物代謝の項, 朝倉書店, 2006.01.
7. 大嶋雄治,横田弘文, 生態影響試験ハンドブック日本環境毒性学会編 内分泌攪乱試験法, 朝倉書店, pp207-220., 2003.01.
8. 大嶋雄治,  栄養・食料科学研究連絡委員会 監修 栄養・食糧科学セレクション2:環境ホルモンと海洋生物資源の未来 生物機能の新展開, 日本学術会議, pp 19-24, 2000.01.
主要原著論文
1. Xuchun Qiu, Sang Gyoon Kim, Ikjoon Kang, Takeshi Hano, Yohei Shimasaki, Yuji Oshima, Combined toxicities of tributyltin and polychlorinated biphenyls on the development and hatching of Japanese medaka (Oryzias latipes) embryos via in ovo nanoinjection, Chemosphere, 10.1016/j.chemosphere.2019.03.104, 927-934, 2019.06, [URL], Tributyltin (TBT) and polychlorinated biphenyls (PCBs) are typical organic pollutants that co-exist in the aquatic environment. Despite increasing awareness of their combined impacts, knowledge about their potential interactive effects remains limited. In this study, we investigated the effects of TBT-PCBs mixtures on the survival, development, and hatching of embryos of Japanese medaka (Oryzias latipes). Our goal was to assess the interactive effects of TBT and PCBs on early-life-stage fish. We used in ovo nanoinjection to simulate the maternal transfer process and to control exposure doses at 0, 7.5, 15, 30 ng/g-egg (for both toxins). A factorial design (4 × 4) corresponding to the above doses was used to define the formulation of mixtures. Results showed that injection of mixtures of TBT and PCBs into fertilized eggs caused significantly elevated rates of mortality, yolk-sac shrinkage, swim-up failure, and deformities of medaka embryos/larvae. TBT and PCBs interacted synergistically to induce the above developmental abnormalities. In contrast, exposure to only TBT increased the hatching times of embryos, whereas exposure to only PCBs decreased the hatching times. The dose ratios, dose levels, and interactive effect of TBT and PCBs in a mixture played significant roles in determining the final impact on time-to-hatching. Our results suggested that in ovo exposure to a mixture of TBT and PCBs may interact synergistically to induce developmental abnormalities in fishes..
2. Xuchun Qiu, Naoto Iwasaki, Kun Chen, Yohei Shimasaki, Yuji Oshima, Tributyltin and perfluorooctane sulfonate play a synergistic role in promoting excess fat accumulation in Japanese medaka (Oryzias latipes) via in ovo exposure, Chemosphere, 10.1016/j.chemosphere.2018.12.191, 220, 687-695, 2019.04, [URL], The ubiquitous environmental obesogens tributyltin (TBT) and perfluorooctane sulfonate (PFOS) may accumulate in parent and be transferred to their offspring, resulting in trans-generational adverse effects. In this study, we investigated the combined toxic and obesogenic effects of TBT and PFOS on the early life stages of Japanese medaka (Oryzias latipes). In ovo nanoinjection was used to simulate the maternal transfer process. Doses were controlled at 0, 0.05, 0.5, and 2.5 ng/egg (TBT) and at 0, 0.05, 0.5, and 5.0 ng/egg (PFOS), with a full factorial design for mixture formulations. Relatively high doses of agents in mixtures were needed to induce significant mortality (TBT ≥ 0.5 ng/egg) or delayed hatching (PFOS = 5.0 ng/egg) of embryos. The interaction between TBT and PFOS in mixtures had significant effects on the observed hatching delay, but not on acute mortality. Compared with controls, separate exposure to TBT (or PFOS) notably elevated adipose areas at the doses of 0.05 and 0.5 ng/egg, but not at the highest doses. Combined exposure significantly promoted the fat accumulation in newly hatched larvae, even when the doses of TBT and PFOS were both at the levels that did not show obesogenic effect. The interactive effect of TBT and PFOS could aggravate the total obesogenic effect of their mixtures, indicating a synergistic interaction. These results highlight the importance of paying close attention to interaction effects when addressing the impacts of mixtures of environmental obesogens..
3. Yoko Kato-Unoki, Yuki Takai, Masato Kinoshita, Toshitaka Mochizuki, Ryohei Tatsuno, Yohei Shimasaki, Yuji Oshima, Genome editing of pufferfish saxitoxin- and tetrodotoxin-binding protein type 2 in Takifugu rubripes, Toxicon, 10.1016/j.toxicon.2018.08.001, 153, 58-61, 2018.10, [URL], The pufferfish saxitoxin- and tetrodotoxin-binding protein 2 (PSTBP2), which is involved in toxin accumulation, was knocked out in Takifugu rubripes embryos by using clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein 9 genome-editing technology. Treating the embryos with one of two single-guide RNA (sgRNA) resulted in mutation rates of 57.1% and 62.5%, respectively, as estimated using a heteroduplex mobility assay at 3 days postfertilization. Both sgRNAs might induced frameshift mutations that knocked out the T. rubripes PSTBP2..
4. M. Honda, X. Qiu, J. Koyama, S. Uno, S. L. Undap, Y. Shimasaki, Y. Oshima, Wharf roach Ligia sp: A novel environmental indicator for polycyclic aromatic hydrocarbons contamination at coastal area., Int J Environ Res, 12, 1-11, 2018.03.
5. Mukai, K., Teramoto, A., Qiu, X., Shimasaki, Y., Kato-Unoki, Y., Lee, J.M., Mizoguchi, N., Khanam, M.R.M., Satone, H., Tatsuke, T.,Kusakabe, T., Oshima, Y.,, Gene structure and cDNA sequence of 2-Cys peroxiredoxin in the harmful algal bloom species Chattonella marina and its gene transcription under different light intensities., European Journal of Phycology, 10.1080/09670262.2017.1346206, 53, 29-38, 2018.01.
6. Khalil, F., Qiu, X., Kang, I.J., Abo-Ghanema, I., Shimasaki, Y., Oshima, Y.,, Comparison of social behavior responses of Japanese medaka ( Oryzias latipes ) to lethal and sublethal chlorpyrifos concentrations at different exposure times., Ecotoxicology and Environmental Safety, 10.1016/j.ecoenv.2017.07.007, 145, 78-82, 2018.01.
7. Honda, M., Muta, A., Shimazaki, A., Akasaka, T., Yoshikuni, M., Shimasaki, Y., Oshima, Y.,, High concentrations of perfluorooctane sulfonate in mucus of tiger puffer fish Takifugu rubripes: a laboratory exposure study., Environ Sci Pollut Res Int, 10.1007/s11356-017-0537-6, 186, 133-138, 2018.01.
8. Qiu, X., Tanoue, W., Kawaguchi, A., Yanagawa, T., Seki, M., Shimasaki, Y., Honjo, T., Oshima, Y.,, Interaction patterns and toxicities of binary and ternary pesticide mixtures to Daphnia magna estimated by an accelerated failure time model. Sci. Total Environ. . doi:10.1016/j.scitotenv.2017.07.034, Sci. Total Environ., 10.1016/j.scitotenv.2017.07.034, 607-608, 367-374, 2018.01, Organisms in natural environments are often exposed to a broad variety of chemicals, and the multi-chemical mixtures exposure may produce significant toxic effects, even though the individual chemicals are present at concentrations below their no-observed-effect concentrations. This study represents the first attempt that uses the accelerated failure time (AFT) model to quantify the interaction and toxicity of multi-chemical mixtures in environmental toxicology. We firstly conducted the acute immobilization tests with Daphnia magna exposed to mixtures of diazinon (DZN), fenitrothion (MEP); and thiobencarb (TB) in single, binary, and ternary formula- tions, and then fitted the results to the AFT model. The 48-h EC50 (concentration required to immobilize 50% of the daphnids at 48 h) values for each pesticide obtained from the AFT model are within a factor of 2 of the cor- responding values calculated from the single pesticide exposure tests, indicating the methodology is able to pro- vide credible toxicity values. The AFT model revealed either significant synergistic (DZN and MEP; DZN and TB) or Daphnia magna.
9. Chen K, Tsutsumi Y, Yoshitake S, Qiu X, Xu H, Hashiguchi Y, Honda M, Tashiro K, Nakayama K, Hano T, Suzuki N, HayakawaK, Shimasaki Y, Oshima Y., Alteration of development and gene expression induced by in ovo-nanoinjection of 3-hydroxybenzo[c]phenanthrene into Japanese medaka (Oryzias latipes) embryos., Aquatic Toxicology, 182, 194-204, 2017.06.
10. Satone H, Nonaka S, Lee JM, Shimasaki Y, Kusakabe T, Kawabata S, Oshima Y., Tetrodotoxin and tributyltin-binding abilities of recombinant pufferfish saxitoxin and tetrodotoxin binding proteins of Takifugu rubripes., Toxicon. 125:50-52(2017), 125, 50-52, 2017.06.
11. Khanam, M.R.M., Shimasaki, Y., Hosain, M.Z., Mukai, K., Tsuyama, M., Qiu, X., Tasmin, R., Goto, H., Oshima, Y.,, Diuron causes sinking retardation and physiochemical alteration in marine diatoms Thalassiosira pseudonana and Skeletonema marinoi-dohrnii complex., Chemosphere, 10.1016/j.chemosphere.2017.02.054, 175, 200-209, 2017.06.
12. Ik Joon Kang, Xuchun Qiu,Junya,Moroishi,Yuji Oshima, Sound production in Japanese medaka (Oryzias latipes) and its alteration by exposure to aldicarb and copper sulfate, Chemosphere, 182, 530-535, 2017.04, This study is the first to report sound production in Japanese medaka (Oryzias latipes). Sound production was affected by exposure to the carbamate insecticide (aldicarb) and heavy-metal compound (copper sulfate). Medaka were exposed at four concentrations (aldicarb: 0, 0.25, 0.5, and 1 mg L−1; copper sulfate: 0, 0.5, 1, and 2 mg L−1), and sound characteristics were monitored for 5 h after exposure. We observed constant average interpulse intervals (approx 0.2 s) in all test groups before exposure, and in the control groups throughout the experiment. The average interpulse interval became significantly longer during the recording periods after 50 min of exposure to aldicarb, and reached a length of more than 0.3 s during the recording periods after 120 min exposure. Most medaka fish stopped to produce sound after 50 min of exposure to copper sulfate at 1 and 2 mg L−1, resulting in significantly declined number of sound pulses and pulse groups. Relative shortened interpulse intervals of sound were occasionally observed in medaka fish exposed to 0.5 mg L−1 copper sulfate. These alternations in sound characteristics due to toxicants exposure suggested that they might impair acoustic communication of medaka fish, which may be important for their reproduction and survival. Our results suggested that using acoustic changes of medaka has potential to monitor precipitate water pollutions, such as intentional poisoning or accidental leakage of industrial waste..
13. M. Honda, H. Gunjikake, S. Matsui, Y. Shimasaki, Y. Oshima, Effect of repeated exposure to low oxygen on respiratory metabolism and vertical movements in the pen shell Atrina lischkeana., Journal of the Faculty of Agriculture, Kyushu University, 62, 387-392, 2017.01.
14. Kase, Y., Ogiso, S., Ikari, T., Sekiguchi, T., Sasayama, Y., Kitani, Y., Shimasaki, Y., Oshima Y., Kambegawa, A., Tabuchi, Y., Hattpri A., and Suzuki, N, Immunoreactive calcitonin cells in the nervous system of polychaete Perinereis aibuhitensis, Journal of the Faculty of Agriculture, Kyushu University, 62, 381-385, 2017.01.
15. Xuchun Qiu, Suzanne Lydia Undap, Masato Honda, Toshio Sekiguchi, Nobuo Suzuki, Yohei Shimasaki, Hironori Ando, Waka Sato-Okoshi, Toshihiro Wada, Tomoki Sunobe, Satoshi Takeda, Hiroyuki Munehara, Hisashi Yokoyama, Noriyuki Momoshima, Yuji Oshima, Pollution of radiocesium and radiosilver in wharf roach (Ligia sp.) by the Fukushima Dai-ichi Nuclear Power Plant accident, Journal of Radioanalytical and Nuclear Chemistry, 10.1007/s10967-016-4879-1, 311, 1, 121-126, 2017.01, [URL], Radionuclide concentrations in wharf roaches inhabiting coastal areas of Honshu, Japan, were investigated in October 2011 and June 2012. Relative high concentrations of 110mAg (2.1–127 Bq kg-wet−1), 134Cs (2.6–61 Bq kg-wet−1), and 137Cs (3.5–92 Bq kg-wet−1) were detected in specimens from the eastern Honshu areas. Significantly lower 137Cs concentrations (0.7–1.6 Bq kg-wet−1) were detected in specimens from western and northern Honshu. The decay-corrected 137Cs concentration was significantly inversely correlated with the distance from the Fukushima Dai-ichi Nuclear Power Plant. Thus, wharf roach may serve as a good bioindicator for monitoring radioactive contamination of its habitats..
16. Liu, H., Chen, X., Su, Y., Qiu, X., Kang., IJ., Shimasaki, Y., Oshima Y., Yang, J. , Effects of Calcium and Magnesium Ions on Acute Copper Toxicity to Glochidia and Early Juveniles of the Chinese Pond Mussel Anodonta woodiana. , Bull of Env Cont Toxi., 97, 504-509, 2016.06.
17. Suzuki, N., Sato, M., Nassar, F. H., Abdel-gawad, F. Kh., Bassem, S.M., Yachiguchi, K., Tabuchi, Y., Endo, M., Sekiguchi, T., Urata, M., Hattori, A., Mishima, H., Shimasaki, Y., Oshima, Y., Hong, C.-S., Makino, F., Tang, N., Toriba, A. and Hayakawa, K.:, Seawater polluted with highly concentrated polycyclic aromatic hydrocarbons suppresses osteoblastic activity in the scales of goldfish, Carassius auratus. , Zool. Sci., 33, 407-413, 2016.06.
18. Qiu, X., Undap, S.L., Honda, M., Sekiguchi, T., Suzuki, N., Shimasaki, Y., Ando, H., Sato-Okoshi, W., Wada, T., Sunobe, T., Takeda, S., Munehara, H., Yokoyama H., Momoshima, N. and Oshima, Y., Pollution of radiocesium and radiosilver in wharf roach (Ligia sp.) by the Fukushima Dai-ichi Nuclear Power Plant accident., J Radioanal Nucl Chem., 311, 121-126, 2016.06.
19. Liu Hongbo, Chen Xiubao, Shimasaki Yohei, Kang Ik Joon, Oshima Yuji, Yang Jian , The valve movement response of three freshwater mussels Corbicula fluminea Müller 1774, Hyriopsis   cumingii Lea 1852, and Anodonta woodiana Lea 1834 exposed to copper. , Hydrobiologia, 270, 1-13, 2016.06.
20. Qiu, X., Mukai, K., Shimasaki, Y., Tsuyama, M., Matsubara, T., Nakajima, Y., ... Oshima, Y., Potential Maximum Quantum Yield of Photosystem II Reflects the Growth Rate of Chattonella marina in Field Bloom Samples., Journal of the Faculty of Agriculture, Kyushu University,, 61, 331-335, 2016.06.
21. Wilmy Etwil Pelle, Masashi Kamo, Takehiko I. Hayashi, Takeshi Kimura, Yohei Shimasaki, Yuji Oshima, Biotic ligand model of copper toxicity to Japanese medaka (Oryzias latipes) in low-hardness water
, 日本環境毒性学会, 18, 2, 59-71, 2015.12.
22. Liu Hongbo, Chen Xiubao, Yohei Shimasaki, Kang Ik Joon, Yamasaki Y, Yuji Oshima, Yang Jian, The valve movement response of three freshwater mussels Corbicula fluminea Müller 1774, Hyriopsis cumingii Lea 1852, and Anodonta woodiana Lea 1834 exposed to copper .
, Hydrobiologia, 10.1007/s10750-015-2560-2, 1-13, 2015.10.
23. Nobuo Suzuki, Somei, M, Atsuhiko HATTORI, Seki, A, Sekiguchi, T, Tabuchi, Y, Mishima, H, Kase, Y, Kaminishi, A, Yachiguchi, K, Kitamura, K, Yuji Oshima, Kazuichi HAYAKAWA, Yano, S, Hattori, A, Novel tryptophan derivatives as potentially effective therapeutic drugs to treat bone diseases., J. Life Sci., in press, in press, 2015.06, Suzuki, N., Somei, M., Seki, A., Sekiguchi, T., Tabuchi, Y., Mishima, H., Kase, Y., Kaminishi, A., Yachiguchi, K., Kitamura, K., Oshima, Y., Hayakawa, K., Yano, S. and Hattori, A.: Am. .
24. Yohei Shimasaki, Michito Tsuyama, Rumana Tasmin, Mst Ruhina Margia Khanam, Xuchun Qiu, Yuji Oshima, Comparative study of toxicological responses of chlorophyll-related parameters in the marine diatom Skeletonema sp. exposed to tributyltin and Irgarol. Jpn., Jpn. J. Environ. Toxicol., 18, 2015.06, Yohei Shimasaki, Michito Tsuyama, Rumana Tasmin, Mst Ruhina Margia Khanam, Xuchun Qiu, Yuji Oshima .
25. Rumana Tasmin, Yohei Shimasaki, Michito Tsuyama, Xuchun Qiu, Khalil F, Okino N, Naotaka Yamada,, Shinji FUKUDA, Yuji Oshima, Kang IJ, Elevated water temperature reduces the acute toxicity of the widely used herbicide diuron to a green alga, Pseudokirchneriella subcapitata. , Environ Sci Poll Res, 21, 1070, 2014.06, Tasmin R, Shimasaki Y, Tsuyama M, Qiu X, Khalil F, Okino N, Yamada N, Fukuda S, Kang IJ, Oshima Y. .
26. Rumana Tasmin, Yohei Shimasaki, Yoshida Y, Matsubara T, Yamasaki Y, Kawaguchi M, Honda M, Mouri K, Nakajima Y, Tasmin R, Kuno K, Kawamura Y, Yuji Oshima, Allelopathic effects of Skeletonema spp. may influence interspecific competition and bloom formation of co-occurring harmful flagellates., Journal of the Faculty of Agriculture, Kyushu University. , 59, 382, 2014.06, Allelopathic effects of Skeletonema spp. may influence interspecific competition and bloom formation of co-occurring harmful flagellates. .
27. 島崎晃成, 本田匡人, 牟田朱美, 赤坂泰輝, 鵜木(加藤)陽子, NOZOMU OKINO, Yohei Shimasaki, Yuji Oshima, ラット血液におけるペルフルオロオクタンスルホン酸結合タンパク質の探索. , 日本環境毒性学会誌 , 17, 11-17 , 2014.04.
28. Nobuo Suzuki, Yusuke MARUYAMA, Masaki NAKANO, Atsuhiko HATTORI, Masato Honda, Toshio Skiguchi, Hiroyuki MISHIMA, Shigehito WADA, Ajai K. SRIVASTAV, Kazuichi HAYAKAWA, 大嶋 雄治, Increased PGE2 Has a Positive Correlation with Plasma Calcium during Goldfish Reproduction.
, J. Fac. Agr, Kyu. Univ., 59, 97-101, 2014.02.
29. Rumana Tasmin, Yohei Shimasaki, Xuchun Qiu, Masato Honda, Michito Tsuyama, Naotaka Yamada,, Shinji FUKUDA, Yuji Oshima, Elevated temperatures and low nutrients decrease the toxicity of diuron for growth of the green alga Pseudokirchneriella subcapitata. , J J Env Tox , 17, 5-10, 2014.02.
30. Suzanne L Undap, Satoshi Matsunaga, Masato Honda, Toshio Skiguchi,, Nobuo Suzuki,, Fatma Khalil, Xuchun Qiu, 島崎 洋平, Hironori Ando, Waka Sato-Okoshi, Tomoki Sunobe, Satoshi Takeda, Hiroyuki Munehara, 大嶋 雄治, Accumulation of organotins in wharf roach (Ligia exotica Roux) and its ability to serve as a biomonitoring species for coastal pollution, ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, 10.1016/j.ecoenv.2013.06.019, 96, 75-79, 2013.10.
31. Suzanne L Undap, Masato Honda, Natalie D. RUMAMPUK, Suguru INOUE, 島崎 洋平, Rizald Max ROMPAS, 望岡 典隆, 大嶋 雄治, Monitoring of Tributyltin Contamination of Demersal Fish in Coastal Water in East China Sea , J. Fac. Agr, Kyu. Univ. , 59, 103-107, 2013.10.
32. 島崎 洋平, 津山 孝人, Rumana Tasmin, Xuchun Qiu, Motoyuki Shimizu, Yusuke Sato, Yasuhiro Yamasaki,, Yoko Kato-Unoki, Atsushi Nukata, Hirofumi Ichinose, Hiroyuki Wariishi, Tsuneo Honjo, 大嶋 雄治, Thiobencarb Herbicide Reduces Growth, Photosynthetic Activity, and Amount of Rieske Iron-Sulfur Protein in the Diatom Thalassiosira pseudonana, JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY, 10.1002/jbt.21505, 27, 9, 437-444, 2013.09.
33. Masato Honda, Akemi Muta, Taiki Akasaka, Yoshiyuki Inoue, 島崎 洋平, Kurunthachalam Kannan, 沖野 望, 大嶋 雄治, Identification of perfluorooctane sulfonate binding protein in the plasma of tiger pufferfish Takifugu rubripes, Ecotox. Environ. Saf. , 104, 409-413, 2013.07.
34. Fatma Khalil, Ik Joon Kang, Suzanne Undap, Rumana Tasmin, Yohei Shimasaki, Yuji Oshima, Alterations in social behavior of Japanese medaka (Oryzias latipes) in response to sublethal chlorpyrifos exposure. , Chemoshphere, 92, 125-130, 2013.02.
35. Nassef M, Kato-Unoki Y, Furuta T, Nakayama K, Satone H, Shimasaki Y, Honjo T, Oshima Y. , Molecular cloning, sequencing, and gene expression analysis of tributyltin-binding protein type 1 in Japanese medaka fish, Oryzias latipes. , Zoological Science , 28:, 281-285, 2011.04.
36. Nakayama K, Sei N,. Handoh I, Shimasaki Y, Honjo T, Oshima Y. , Effects of polychlorinated biphenyls on liver function and sexual characteristics in Japanese medaka (Oryzias latipes). , Mar Poll Bull , 28:, (in printing), 2011.04.
37. Satone H, Lee JM, Oba Y, Kusakabe T, Akahoshi E, Miki S, Suzuki N, Sasayama Y, Nassef M, Shimasaki Y, Kawabata S, Honjo T, Oshima Y , Tributyltin-binding protein type 1, a lipocalin, prevents inhibition of osteoblastic activity by tributyltin in fish scales. , Aquat Toxicol , 103, 79-84, 2011.04.
38. Hano T, Oshima Y, Kinoshia M, Tanaka M, Mishima N, Wakamatsu Y, Ozato K, Shi-masaki Y, Honjo T. , Evaluation of the effects of ethinylestradiol (EE2) on sexual differentiation in the olvas-GFP/STII-YI medaka (transgenic Oryzias latipes) strain as estimated by proliferative activity of germ cells. , Aquat Toxicol , (accepted), 2011.04.
39. 本田匡人,郡司掛博昭,松井繁明,諸石淳也,姜益俊,島崎洋平,大嶋雄治. , サルボウガイ(Scapharca subcrenata)の呼吸代謝に及ぼす低酸素の影響. , 九州大学農学部学芸誌, 65, 31-37, 2010.07.
40. Nassef M , Matsumoto S, Seki M, khalil F, Kang IJ, Shimasaki Y, Oshima Y, Honjo T. , Acute effects of triclosan, diclofenac and carbamazepine on feeding performance of Japanese medaka fish (Oryzias latipes) , Chemosphere, 80: 1095-1100, 79:966-973 , 2010.04, The toxicity of three pharmaceutical and personal care products (PPCPs) – carbamazepine (CBMZ), diclofenac (DCF), and triclosan (TCS) – was examined by measuring their effects on feeding behavior and swimming speed of adult Japanese medaka fish (Oryzias latipes). Medaka were exposed to 6.15 mg L−1 CBMZ, 1.0 mg L−1 DCF, 0.17 mg L−1 TCS, or no PPCP (control) for 9 d. Fish behaviors were monitored during days 5–9 of the exposure period. Feeding behavior (time to eat midge larvae, TE) and swimming speed (SS) of individual exposed and control fish were tracked in two dimensions, using an automated system with a digital charge-coupled device camera. As a result, feeding behavior was affected by exposure to CBMZ and DCF, while SS was altered by exposure to CBMZ and TCS. Thus, TCS, DCF and CBMZ appear to affect fish behaviors through different mechanisms. Overall, the results suggest that behavioral changes may provide a sensitive indicator for assessing the toxicity of PPCPs to aquatic organisms..
41. Oba Y, Yamauchia A, Hashiguchi Y, Satonea H, Miki S, Nassef M, Shimasaki Y, Kitano T, Nakao M, Kawabata S, Honjo T, Oshima Y, Purification and charac-terization of tributyltin-binding protein of tiger puffer, Takifugu rubripes. , Comp Biol phys C., 153, 17-23, 2010.04.
42. Qiu X, Yamasaki Y, Shimasaki Y, Gunjikake H, Shikata T, Matsubara T, Nagasoe S, Honjo T, Oshima Y. , Growth interactions between raphidophytes Chattonella antiqua and Heterosigma akashiwo. , Thalasas, 27, 33-45, 2010.04.
43. Nassef M, Tawaratsumida T, oba Y, Satoe H, Nakayama K, Shimasaki Y, Honjo T, Oshima Y. , Induction of tributyltin-binding protein type 2 in Japanese flounder, Paralichthys olivaceus, by exposure to tributyltin-d27. , Mar Poll Bull , 62, 412-414, 2010.04.
44. Nassef M, Kim SG, Seki M, Kang IJ, Hano T, Shimasaki Y, Oshima Y. , In ovo nanoinjection of triclosan, diclofenac and carbamazepine affects embryonic development of medaka fish (Oryzias latipes). , Chemosphere , 79:966-973 , 2010.03.
45. Nassef M, Matsumoto S, Seki M, Kang IJ, Moroishi J, Shimasaki Y and Oshima Y., Pharmaceuticals and personal care products toxicity to medaka fish. . , J. Fac. Agr. Kyushu Univ. 2009;55:407-411., 76: 1013-1015., 2009.08.
46. Hano T, Kinoshita M, Tanaka M, Y. W, Ozato O, Shimasaki Y, Oshima Y and Honjo T., Ovo nanoinjection of nonylphenol affects embryonic development of olvas-GFP/ST-II YI medaka, Oryzias latipes., Chemosphere , 77:1594-1599., 2009.08.
47. 郡司掛博昭, 大嶋雄治, 松井繁明, 田上 航, 今石幸治, 本田匡人, 諸石淳也, 姜益俊, 島崎洋平, 本城凡夫, 低酸素海水に反復暴露したリシケタイラギ(Atlina lischkeana)の浮上行動とへい死. , 九州大学大学院農学研究院学芸雑誌, 64: 19-22, 2009.02.
48. Kang IJ, Moroishi J, Nakamura A, Nagafuchi K, Kim SG, Oshima Y. , Biological monitoring of detection of toxic chemicals in water by the swimming behavior of small freshwater fish., Journal of the Faculty of Agriculture Kyushu University, 54: 209-214, 2009.02.
49. Satone H, Oshima Y, Shimasaki Y, Tawaratsumita T, Oba Y, Takahashi E, Kitano T, Kawabata S, Kakuta Y, Honjo T., Tributyltin-binding protein type 1 has a distinctive lipocalin-like structure and is involved in the excretion of tributyltin in Japanese flounder, Paralichthys olivaceus. , Aquatic Toxicology, 90: 292-299., 2008.12.
50. Kang IJ, Yokota H, Oshima Y, Tsuruda Y, Shimasaki Y, and Honjo T. , The effects of methyltestosterone on the sexual development and reproduction of adult medaka (Oryzias latipes). , Aquatic Toxicology , 87: 37-46., 2008.04.
51. Nakayama K, Sei N, Oshima Y, Tashiro K, Shimasaki Y, Honjo T., Alteration of gene expression profiles in the brain of Japanese medaka (Oryzias latipes) exposed to KC-400 or PCB126. , Marine Pollution Bulletin , 2008.03.
52. Shimasaki Y, Oshima Y, Inoue Y, Shibata H, Nakayama K, Inoue S, Imoto H, Kang IJ, Honjo T. , Distribution of tributyltin in tissues of mature Japanese whiting, Sillago japonica and their eggs. , Journal of Faculty of Agriculture Kyushu University, 53: 67-72., 2008.02.
53. Hano T, Oshima Y, Kim SG, Satonne H, Ooba Y, Kitano T, Inoue S, Shimasaki Y, Honjo T., Tributlyltin causes abnormal development in embryo of medaka, Oryzias latipes., Chemosphere, 69: 927-933, 2007.10.
54. S. Inoue, Y. Oshima, S. Abe, R. Wu, K. Nakayama, T. Honjo, Effects of tributyltin on energy metabolism of pen shell (Atrina pectinata japonica), Chemosphere, , 66, 1226-1229, 2007.01.
55. K. Nakayama, Y. Oshima, T. Tachibana, M. Furuse, T. Honjo, Alteration of monoamine concentrations in the brain of medaka, Oryzias latipes, exposed to tributyltin. , , Environmental Toxicology, , 22,53-57, 2007.01.
56. Hano, T., Y. Oshima, M. Kinoshita, M. Tanaka, N. Mishima, T. Ohyama, T. Yanagawa, Y. Wakamatsu, K. Ozato, T. Honjo., Quantitative bioimaging analysis of gonads in olvas-GFP/ST-II YI medaka (transgenic Oryzias latipes) exposed to ethinylestradiol., Environ Sci Tech, 41, 1473-1479., 2007.01.
57. Inoue, S., Y. Oshima, H. Usuki, M. Hamaguchi, Y. Hanamura, N. Kai, Y. Shimasaki, T. Honjo. , Effect of tributyltin on veliger larvae of the Manila clam, Ruditapes philippinarum, , Chemosphere, 66, 1353-1357, 2007.01.
58. 伊藤 靖, 大嶋雄治, 磯部貞佑, Kamal Elnabris, 島崎洋平, 本城凡夫,, 海産自由生活性線虫Prochromadorella sp.1の生涯試験を用いた銅、ビスフェノールAおよびノニルフェノールの毒性評価, 日本環境毒性学会誌, 9, 23-29, 2006.06.
59. Kang IJ, Hano T, Oshima Y, Yokota H, Tsuruda Y, Shimasaki Y, Honjo T., Anti-androgen flutamide affects gonadal development and reproduction in medaka (Oryzias latipes)., Mar Env Res., 62 Suppl 1:S253-7, 2006.04.
60. Shimasaki Y, Oshima Y, Inoue S, Inoue Y, Kang I J, Nakayama K, Imoto H and Honjo H., Effect of tributyltin on reproduction in Japanese whiting, Sillago japonica., Mar Env Res, 62 Suppl 1:S245-8, 2006.04.
61. Inoue S, Oshima Y, Usuki H, Hamaguchi M, Hanamura Y, Kai N, Shimasaki Y, Honjo T., Effects of tributyltin maternal and/or waterborne exposure on the embryonic development of the Manila clam, Ruditapes philippinarum, Chemosphere, 63,881-888, 2006.04.
62. Nakayama K, Oshima Y, Hiramatsu, Shimasaki Y, and Honjo T., Effects of polychlorinated biphenyls on the schooling behavior of Japanese medaka, Oryzias latipes., Environ Toxicol Chem, 10.1897/04-518R2.1, 24, 10, 2588-2593, 24: 2588-2593, 2005.01.
63. Inoue S, Abe S, Oshima Y, Kai N, Honjo T., Tributyltin contamination of the bivalves in coastal areas around northern kyushu, Japan., Environmental Toxicology, 10.1002/tox.20177, 21, 3, 244-249, 21:244-249, 2005.01.
64. Oshima Y, Koyama J, Nakayama K, Inoue Y, Shimasaki Y, Inoue S and Honjo T., Use of hepatic CYP1A1 activity in Japanese flounder to monitor oil dispersed from the Nakhodka spill, Jpn J Environ Toxicol, 7:123-129, 2005.01.
65. Oshima Y, Takeda T, Katayama S, Inoue Y, Inoue S, Nakayama K, Shimasaki Y, and Honjo T., Relationship between temperature and pharmacokinetic parameters of florfenicol in carp (Cyprinus carpio), Jpn J Environ Toxicol, 7:61-68, 2005.01.
66. Inoue S, Oshima Y, Nagai K, Yamamoto T, Go J, Hiramatsu J, Okada M, Imada N and Honjo T, Maternal effect of tributyltin on reproduction of pearl oyster, Pinctada fucata martensii, Environ Toxicol Chem, 23, 1276-1281, 2004.01.
67. Nakayama K, Oshima Y, Yamaguchi T, Tsuruda Y, Kang IJ, Kobayashi M, Imada N, Honjo T, Fertilization success and sexual behavior in male medaka, Oryzias latipes, exposed to tributyltin, Chemospheres, 10.1016/j.chemoshere.2003.11.050, 55, 10, 1331-1337, 55. 1331-1337, 2004.01.
68. Omura M, Shimasaki Y, Oshima Y, Nakayama K, Kubo K, Saou S, Ogata R, Hirata M, Inoue N., Distribution of tributyltin, dibutyltin and monobutyltin in the liver, brain and dat of rats: two-generation toxicity study of tributyltin chloride, Environ Sci, 11, 123-132, 2004.01.
69. Hano T, Oshima Y, Oe T, Kinoshita M, Tanaka M, Wakamatsu Y, Ozato K, Honjo T., A quantitative bioimaging analysis in the evaluation of sexual differentiation on germ cells of olvas-GFP/ST II-YI medaka, Oryzias latipes, nanoinjected with ethinyl estradiol., Environ Toxicol Chem, 24:70-77, 2004.01.
70. Nakayama K, Oshima Y, Nagafuchi K, Hano T, Shimasaki Y, and Honjo T., Early life stage toxicity in offspring from exposed parent medaka, Oryzias latipes, to mixtures of tributyltin and polychlorinated biphenyls., Environ Toxicol Chem (accepted), 10.1897/04-157R.1, 24, 3, 591-596, 24, 591?596, 2004.01.
71. Koutoku T, Zhang R, Tachibana T, Oshima Y and Furuse M., Effect of acute l-tryptophan exposure on the brain serotonergic system and behavior in the male medaka, Zoological Science, 10.2108/zsj.20.121, 20, 2, 121-124, 20: 121-124, 2003.01.
72. Kang IJ, Yokota H, Oshima Y, Tsuruda Y, Hano T, Maeda M, Imada N, Tadokoro H and Honjo T, Effects of 4-nonylphenol on reproduction of japanese medaka (Oryzias latipes), Environ Toxicol Chem, 10.1897/02-225, 22, 10, 2438-2445, 22:2438-2445, 2003.01.
73. Kang IJ, Yokota H, Oshima Y, Tsuruda Y, Yamaguchi T, Oe T, Imada N, Tadokoro H and Honjo T., Effects of bisphenol A on the reproduction of Japanese medaka (Oryzias latipes)., Environ Toxicol Chem, 10.1897/1551-5028(2002)021<2394:EOBAOT>2.0.CO;2, 21, 11, 2394-2400, 20:2394-2400, 2002.01.
74. Shimasaki Y, KitanoT, Oshima Y, Inoue S, Imada N and Honjo T., Tributyltin causes masculinization in fish, Environ Toxicol Chem, 10.1897/1551-5028(2003)022<0141:TCMIF>2.0.CO;2, 22, 1, 141-144, 22: 141-144, 2002.01.
75. Oshima Y, Kang IJ, Kobayashi M, Nakayama K, Imada N, Tadokoro H and Honjo T., Suppression of sexual behavior in male Japanese medaka (Oryzias latipes) exposed to 17_-estradiol, Chemospheres, 10.1016/S0045-6535(02)00494-0, 50, 3, 429-436, 50: 429-436, 2002.01.
76. 井上 英,大嶋雄治,今田信良,本城凡夫, 北部九州とその周辺水域におけるトリブチルスズ汚染, 環境毒性学会誌, 5: 43-50, 2002.01.
77. Shimasaki Y, Oshima Y, Yokota Y, Kitano T, Nakao M, Kawabata S, Imada N and Honjo T., Purification and identification of a TBT-binding protein from serum of Japanese flounder, Paralichthys olivaceus., Environ Toxicol Chem, 10.1897/1551-5028(2002)021<1229:PAIOAT>2.0.CO;2, 21, 6, 1229-1235, 21: 1229-1235., 2002.01.
主要総説, 論評, 解説, 書評, 報告書等
1. 大嶋 雄治, トリブチルスズの魚貝類への影響に関する生殖生理学的および生化学的研究. , 日本水産学会誌, Vol. 75 (2009) No. 3 pp.354-356., 2009.08.
2. Yuji Oshima, Kei Nakayama, Takashi Hano, Sang Gyoon Kim, Yohei Shimasaki, Ik Joon Kang, Tsuneo Honjo. , Toxic Interactions Between Tributyltin and Polychlorinated Biphenyls in Aquatic Organisms Ed T. Arai et al (eds.), , Environmental Impact of Antifouling Biocides, 2009. 195-205, 2009.02.
3. Kei Nakayama, Yuji Oshima, Adverse effects of tributyltin on reproduction of Japanese medaka, Oryzias latipes. , Coastal Marine Science, 2008.04.
4. 大嶋雄治, 化学物質の生態リスクー水圏におけるトリブチルスズとPCBsの低濃度相乗作用の懸念. , 日本水産資源保護協会 506:3-7., 2007.05.
5. 姜 益俊、山菅美利、大嶋雄治、, 魚類(メダカ)の行動を用いた水質監視装置、, 資源環境対策、, 42, 81-85, 2006.01.
6. 大嶋雄治・島崎洋平・本城凡夫, 有機スズ化合物汚染のHot spotと海産生物への影響, 日本マリンエンジニアリング学会, 40:32-34, 2005.01.
7. 大嶋雄治, 本城凡夫, 流出油の生態系への影響と中・長期モニタリング, 水産学会シリーズ 流出油の生態系への影響と中・長期モニタリング/大和田紘一 編 恒星社厚生閣, ., 2004.01.
8. 大嶋雄治, 本城凡夫, 水産学会シリーズ 140 / 微量人工化学物質の生物モニタリング III.- 1. メダカ, 恒星社厚生閣, 87?96., 2004.01.
9. 大嶋雄治, 私の視点「環境ホルモン 複合汚染に注意が必要, 朝日新聞朝刊全国版, 1/19/2004, 2004.01.
10. 大嶋雄治,横田弘文., 内分泌攪乱試験法., 生態影響試験ハンドブック 日本環境毒性学会編 朝倉書店, 207-220., 2003.01.
11. 大嶋雄治,井上英,島崎洋平,仲山 慶,本城凡夫, 沿岸域におけるトリブチルスズ汚染の現状と魚介類への影響, 海洋と生物, 144: 11-14., 2003.01.
12. 大嶋雄治, 本城凡夫, 魚類の性行動への影響, 環境ホルモン 藤原書店, 1: 30-39., 2000.01.
主要学会発表等
1. Mst Ruhina Margia Khanam, Yohei Shimasaki, Koki Mukai, Yuji Oshima. , Effects of TBT on sinking rate and physiological parameters of marine planktonic diatom, Thalassiosira pseudonana. , PICES-2019 Annual Meeting, 2019.10.
2. Koki Mukai, Yohei Shimasaki, Yukie Ohara and Yuji Oshima. , Effect of environmental factors on bloom formation of the toxic dinoflagellate Alexandrium catenella in kariya Bay of northern Kyushu in Japan. , PICES-2019 Annual Meeting, 2019.10.
3. Y. Oshima, T. Takamura, S. Enoki, Y. Kato-Unoki, Y. Nagano, M. Kinoshita, T. Kitano, IJ. Kang, X. Qiu, Y. Shimasaki. , Toxicity of tributyltin and triclosan in tributyltin-binding protein 2 knocked-out medaka, Oryzias latipe , 9th International Conference on Marine Pollution and Ecotoxicology, 2019.06.
4. Y. Oshima, M. Asas, C. Kun, H. Ogawa, H. Xu, Y. Liu , X. Qiu, Y. Shimasaki,, Accumulation of microplastics and its reproductive effect on medaka fish. , 9th International Conference on Marine Pollution and Ecotoxicology, 2019.06.
5. Y. Oshima, T. Takamura, S. Enoki, Y. Kato-Unoki, Y. Nagano, M. Kinoshit, T. Kitano, I. J. Kang, X. Qiu, Y. Shimasaki. , Toxicity of tributyltin and triclosan in tributyltin-binding protein 2 knocked-out medaka, Oryzias latipes., SETAC North America 40th Annual Meeting, 2019.11.
6. Xuchun Qiu, SangGyoon Kim, Ik Joon Kang, Takeshi Hano, Yohei Shimasaki, Yuji Oshima, Combined toxicities of tributyltin and polychlorinated biphenyls on the development and hatching of Japanese medaka (Oryzias latipes) embryos via in ovo nanoinjection, SETAC North America 40th Annual Meeting, 2019.11.
7. Y.Oshima, H. Ogawa, Y. Liu, Y. Shimasaki,, Accumulation of microplastics on medaka fish and artemia. SETAC North America 40th Annual Meeting, Nov 1st- 9th, Tronto, Canada., SETAC North America 40th Annual Meeting,, 2019.11.
8. Souvannasing Saovany, Mami Waseda, Yohei Shimasaki, Yuji Oshima, Ayumi Akasaka, Yasuyuki Suzuki, Takeshi Ishibashi, Yoshiyuki Inoue , The vector effects of microplastics on anthracene bioaccumulation in Japanese medaka (Oryzias latipes), 日本環境毒性学会, 2019.09.
9. 高村 匠、榎 眞太郎、島崎 洋平、大嶋 雄治、鵜木 陽子、邱 旭春 , 遺伝子ノックアウトメダカを用いた毒性試験によるトリブチルスズ結合タンパク質の毒性軽減機能の解析, 日本環境毒性学会, 2019.09.
10. 大嶋雄治、劉揚清、小川 聖、島崎 洋平 , メダカにおけるマイクロプラスチックの体内動態, 日本環境毒性学会, 2019.09.
11. 小松正治, LEE JAE MAN, 橋口康之, 白石 真, 野中翔平, 島崎 洋平, 望岡 典隆, 日下部 宜宏, 大嶋 雄治, フグ毒結合タンパク質の魚種間分布 , 平成 25 年度日本水産学会春季大会, 2013.03.
12. 小松正治, LEE JAE MAN, 橋口康之, 白石 真, 野中翔平, 島崎 洋平, 望岡 典隆, 日下部 宜宏, 大嶋 雄治, フグ毒結合タンパク質の魚種間分布 , 平成 25 年度日本水産学会春季大会, 2013.03.
13. Nakamura A, JAE MAN LEE, takahiro kusakabe, Miki S, Nonaka S, Komatsu S, Yohei Shimasaki, Yuji Oshima, Binding of tributyltin to recombinant saxitoxin and tetrodotoxin binding protein from the puffer fish Takifugu rubupires., SETAC Asia Pacific 2012, 2012.11.
14. 橋口康之・Lee Jaeman・白石 真・小松正治・三木志津帆・島崎洋平・日下部宣宏・大嶋雄治., フグ科魚類におけるフグ毒結合タンパク質の分子進化., 2012.03.
15. 大嶋 雄治, EST解析を用いた有明海における福岡県沖および佐賀県沖産タイラギ集団の遺伝的差異, 2012.03.
16. 中村愛子, LEE JAE MAN, 小松正治, 三木志津帆, 島崎 洋平, 日下部 宜宏, 大嶋 雄治, トラフグPSTBP および TBT-bp2 の組換え体を用いた生体内リガンドの探索., 日本水産学会, 2012.03.
17. Yuji Oshima, Toxicity of tributyltin and detoxification and excretion function of tributlytin binding protein. , 2011Marine Ecotoxical Symposium, 2011.09.
18. 大嶋雄治, , 魚類リポカリンは異物(トリブチルスズやフグ毒)と結合し体表粘液から排泄する機能を持つ, 環境ホルモン学会, 2010.12.
19. Nassef M , Seki M, Shimasaki Y, Oshima Y , Toxic responses of embryos of Japanese medaka fish (Oryzias latipes) to pharmaceuticals and personal care products using in ovo nanoinjection Poster, Society of Environmental Toxicology and Chemistry Asia Pacific, 2010.06.
20. Oshima Y, Satone H, Yumi Oba Y, Lee JM, Kusakabe T, Kawabata S, Shimasaki Y, Suzuki N, and Sasayama Y. , THE DETOXIFICATION AND EXCRETION FUNCTION OF TRIBUTYLTIN BINDING PROTEIN IN JAPANESE FLOUNDER, Paralichthyes olivaceus, Society of Environmental Toxicology and Chemistry Asia Pacific, 2010.06.
21. M Nassef, Y K Unoki, Y Shimasaki and Y Oshima , GENE EXPRESSION PROFILE IN MEDAKA FISH EXPOSED TO TRICLOSAN, DICLOFENAC AND CARBAMAZEPINE POSTER, International Conference on Marine Pollution, 2010.05.
22. Y Oshima, T. Tawaratsumida, Y OBA, H SATONE, Y SHIMASAKI , INDUCTION OF THE TRIBUTYLTIN-BINDING PROTEIN 2 OF JAPANESE FLOUNDER, Paralichthys olivaceus BY EXPOSURE OF TRIBUTYLTIN-d2, International Conference on Marine Pollution, 2010.05.
23. Miki S., Ikeda K., Oba Y., Satone H., Shimasaki Y., Onikira N., Arakawa O, Oshima Y. , Accumulation of tributyltin in the blood of pufferfish, Society of Environmental Toxicology and Chemistry, 2010.05.
24. Satone H., Lee J.M., Kusakabe T., Kawabata, S., Suzuki N. , Sasayama Y. , Oba Y., Shimasaki Y., Oshima Y. , Tributyltin-binding protein type 1 rescued the inhibition of oste-oblastic activity induced by TBT , Society of Environmental Toxicology and Chemistry, 2010.05.
25. Oshima, Y., Ooba Y., Satone H., Shimasaki, Y., Hashiguchi, Y. , Analysis of the tribu-tyltin-binding protein gene of Japanese flounder, Paralichthys olivaceus., Society of Environmental Toxicology and Chemistry, 2010.05.
26. Oshima, Y., Tanoue W. , Kawaguchi , A., Yanagawa T. and Shimasaki, Y. , Synergistic toxicities of diazinon, fenitrothion and benthiocarb on Daphnia magna, Society of Environmental Toxicology and Chemistry, 2010.05.
27. 大嶋雄治、佐藤根妃奈、大場由美、李在萬、日下部宜宏、川畑俊一郎、島崎洋平、鈴木信雄、笹山雄一 , トリブチルスズ結合タンパク質とその遺伝子組換え体によるトリブチルスズーキンギョ鱗骨芽細胞 アルカリホスファターゼ活性阻害の回復, 日本内分泌かく乱学会, 2009.12.
28. Yuji Oshima, Shuhei Matsumoto, Sang Gyoon Kim, Kei Nakayama, Ik Joon Kang, Yohei Shimasaki, and Tsuneo Honjo , Evaluation of mixture toxicity and its mechanism on medaka (Oryzias latipes) embryos nanoinjected with a binary mixture of tributyltin and polychlorinated biphenyls, 30th Meeting of Society of Society of Environmental Toxicology and Chemistry, 2009.11.
29. 山崎康裕・長副 聡・紫加田知幸・為石正幸・島崎洋平・大嶋雄治・山口健一・小田達也・本城凡夫( , ラフィド藻 Heterosigma akashiwo と渦鞭毛藻 Prorocentrum minimum の増殖相互作用, 日本水産学会秋季大会, 2009.09.
30. Yumi OBA, Akira YAMAUCHI, Yuji OSHIMA, Yohei SHIMASAKI, Hina SATONE, Takeshi KITANO, Miki NAKAO, Shun-ichiro KAWABATA and Tsuneo HONJO , Tribu-tyltin-binding proteins from blood of Tiger puffer, Takifugu rubripes., 14th International Symposium on Toxicity Assessment (ISTA14), 2009.09.
31. Yumi OBA, Akira YAMAUCHI, Yuji OSHIMA, Yohei SHIMASAKI, Hina SATONE, Takeshi KITANO, Miki NAKAO, Shun-ichiro KAWABATA4 and Tsuneo HONJO , Tribu-tyltin-binding proteins from blood of Tiger puffer, Takifugu rubripes., 14th International Symposium on Toxicity Assessment (ISTA14), 2009.09.
32. 郡司掛博昭,大嶋雄治,松井繁明,田上 航,今石幸治,本田匡人,諸石淳也,姜益俊,島崎洋平,本城凡夫.  , 低酸素海水に反復暴露したリシケタイラギ (Atrina lischkeana )の浮上行動と斃死, 日本水産学会春季大会, 2009.03.
33. Mohamed Nassef, Shuhei Matsumoto, Masanori Seki, Yohei Shimasaki, Yuji Oshima. , Mixture toxicity of pharmaceuticals and personal care products combinations on embryos of medaka fish (Oryzias latipes) by in ovo nanoinjection., 日本水環境学会 九州支部大会, 2009.02.
34. 郡司掛博昭、大嶋雄治,松井繁明,田上航,今石幸治,本田匡人,諸石淳也,姜益俊,島崎洋平,本城凡夫. , 低酸素海水に反復暴露したリシケタイラギ(Atlina lischkeana )の浮上行動と斃死, 日本水産学会九州支部大会, 2009.01.
35. H. Satone, Y. Oshima, Y. Shimasaki, E. Takahashi, T. Tawaratsumita, Y. Oba, T. Kitano, S. Kawabata, Y. Kakuta and T. Honjo., Genomic sequence, secondary and tertiary structures of tributyltin-binding protein type 1 in Japanese flounder, Paralichthys olivaceus, and its role in the excretion of tributyltin via mucus., World Fisheries Congress , 2008.11.
36. S. Matsumoto, Y. Oshima, S. G. Kim, K. Nakayama, I.J. Kang, T. Suzuki, Y. Shimasaki, and T. Honjo. , Evaluation of mixture toxicity and its mechanism on medaka (Oryzias latipes) embryos nanoinjected with a binary mixture of tributyltin and polychlorinated biphenyls, World Fisheries Congress , 2008.11.
37. Y. Oba, A. Yamauchi, Y. Oshima, Y. Shimasaki, H. Satone, T. Kitano, M. Nakao, S-I. Kawabata, and T. Honjo. , Purification of tributyltin-binding proteins from blood of Japanese flounder, Paralichthys olivaceus and Tiger puffer, Takifugu rubripes, World Fisheries Congress , 2008.11.
38. Y. Oshima, S. Matsumoto, S-G. Kim, K. Nakayama, I-J. Kang, T. Suzuki, Y. Shimasaki, and T. Honjo. , Evaluation of mixture toxicity and its mechanism on medaka (Oryzias latipes) embryos nanoinjected with a binary mixture of tributyltin and polychlorinated biphenyls, World Fisheries Congress , 2008.11.
39. Y. Oshima, S. Matsumoto, S-G. Kim, K. Nakayama, I-J. Kang, T. Suzuki, Y. Shimasaki, and T. Honjo. , Evaluation of mixture toxicity and its mechanism on medaka (Oryzias latipes) embryos nanoinjected with a binary mixture of tributyltin and polychlorinated biphenyls, World Fisheries Congress , 2008.11.
40. Shikata, T., Matsubara, T., Yoshikawa, S., Nukata, A., Nagasoe, S., Yamasaki, Y., Shimasaki, Y., Oshima, Y., Jenkinson, I.R. & Honjo, T. , Effects of light quality on the initiation and development of Skeletonema costatum blooms., 13th International Conference on Harmful Algae, 2008.11.
41. 瀬井直美・大嶋雄治・仲山慶・安東宏徳・田代康介・島崎洋平・本城凡夫:, メダカ脳の遺伝子発現に及ぼすトリブチルスズの影響, 日本内分泌攪乱化学物質学会, 2007.12.
42. 金相均・大嶋雄治・松本充平・瀬井直美・仲山慶・姜益俊・鈴木徹・島崎洋平・本城凡夫:, メダカ胚―ナノインジェクションを用いたトリブチルスズとポリ塩化ビフェニルの複合毒性の評価と機構解明, 日本内分泌攪乱化学物質学会, 2007.12.
43. 箱大場由美・島崎洋平・大嶋雄治・佐藤根妃奈(九大院農)・北野健(熊大院理)・中尾実樹(九大院農)・川畑俊一郎(九大院理)・本城凡夫(九大院農):, ヒラメ( Paralichthys olivaceus )トリブチルスズ結合タンパク質タイプ2の遺伝子解析, 日本水産学会, 2007.09.
44. 大場由美・島崎洋平・大嶋雄治・中尾実樹・北野健・川畑俊一郎・本城凡夫, ヒラメ( Paralichthys olivaceus )におけるトリブチルスズ結合タンパク質タイプ2遺伝子の解析, 日本環境ホルモン学会, 2006.11.
45. 佐藤根妃奈・高橋英理子・大嶋雄治・島崎洋平・北野健・川畑俊一郎・本城凡夫, ヒラメ( Paralichthys olivaceus )におけるトリブチルスズ結合タンパク質タイプ1遺伝子の解析およびその機能に関する研究, 日本環境ホルモン学会, 2006.11.
46. Y. Oshima, K. Nakayama, S. G. Kim, Y. Shimasaki, and T. Honjo, Mixture toxicities of tributyltin and polychlorinated biphenyls on medaka (Oryzias latipes) , SETAC Asia/Pacific, 2006.09.
47. W. Tanoue, Y. Oshima, A. Kawaguchi, T. Yanagawa, M. Maeda, T. Nosaka, Y. Shimasaki, and T. Honjo, Synergistic toxicities of diazinon, fenitrothion and benthiocarb on Daphnia magna., SETAC Asia/Pacific, 2006.09.
48. 大嶋雄治・島崎洋平・佐藤根妃奈・大場由美・高橋英理子(九大院農)・白水 剛・北野 健(熊大理)・川畑俊一郎(九大院理)・本城凡夫(九大院農), ヒラメにおけるトリブチルスズ結合タンパク質の遺伝的解析, 日本水産学会H17年度春季大会, 2006.03.
特許出願・取得
特許出願件数  5件
特許登録件数  1件
学会活動
所属学会名
Society of Environmental Toxicology and Chemistry
日本水産学会
日本内分泌かく乱化学物質学会
日本環境毒性学会
日本水環境学会
学協会役員等への就任
2020.03~2021.02, 日本水産学会, 理事.
2019.09~2021.08, 日本環境毒性学会, 副会長.
2013.04~2018.03, 日本水産学会, 水産環境保全委員会委員.
2015.05~2018.06, 有明海・八代海研究者会議, 代表.
2014.05~2018.06, 有明海再生機構, 理事.
2007.04~2016.05, 日本水産学会, 水産教育委員.
2003.04~2018.05, 日本内分泌撹乱物質学会, 評議員.
2005.08, 日本環境毒性学会, 評議員.
学会大会・会議・シンポジウム等における役割
2014.09.10~2013.09.11, 日本環境毒性学会, 座長(Chairmanship).
2013.09.07~2013.09.08, 日本環境毒性学会, 座長(Chairmanship).
2012.09.02~2012.09.03, 日本環境毒性学会, 座長(Chairmanship).
2013.03.27~2013.03.31, 日本水産学会, 座長(Chairmanship).
2011.09.02~2011.09.03, 日本環境毒性学会, 座長(Chairmanship).
2010.12.16~2010.12.17, 環境ホルモン学会, 座長(Chairmanship).
2009.09, 日本環境毒性学会, 座長(Chairmanship).
2009.03.27~2009.03.31, 日本水産学会, 座長(Chairmanship).
2008.10.20~2008.10.24, 5th World Fisheries Congress,, 座長(Chairmanship).
2007.09, 日本環境毒性学会, 座長(Chairmanship).
2006.09, 日本環境毒性学会, 座長(Chairmanship).
2005.09, 日本環境毒性学会, 座長(Chairmanship).
学会誌・雑誌・著書の編集への参加状況
2014.03~2020.03, Fisheries Science, 国際, 編集委員.
2014.03~2020.03, 日本水産学会誌, 国内, 編集委員.
2013.09~2015.08, 日本環境毒性学会, 国内, 編集委員長.
2002.02~2003.01, Chemosphere, 国際, 編集委員.
学術論文等の審査
年度 外国語雑誌査読論文数 日本語雑誌査読論文数 国際会議録査読論文数 国内会議録査読論文数 合計
2018年度
2017年度
2016年度 12 
2015年度
2014年度 12 
2013年度 10  13 
2012年度 12  14 
2011年度 10 
2010年度
2009年度
2008年度
2007年度
2006年度
2005年度
2004年度
2003年度
2002年度
その他の研究活動
外国人研究者等の受入れ状況
2016.01~2016.01, 2週間以上1ヶ月未満, Freshwater Fisheries Research Center, Chinese Academy of Fishery Sciences, China, 科学技術振興事業団.
2015.09~2015.11, 1ヶ月以上, Freshwater Fisheries Research Center, Chinese Academy of Fishery Sciences, China, 科学技術振興事業団.
2016.03~2018.03, 1ヶ月以上, School of Environment and Safety Engineering, Jiangsu University, China, 外国政府・外国研究機関・国際機関.
2015.01~2014.02, 1ヶ月以上, Freshwater Fisheries Research Center, Chinese Academy of Fishery Sciences, China, 科学技術振興事業団.
2014.01~2014.02, 1ヶ月以上, Freshwater Fisheries Research Center, Chinese Academy of Fishery Sciences, China, 科学技術振興事業団.
2013.05~2013.06, 1ヶ月以上, Freshwater Fisheries Research Center, Chinese Academy of Fishery Sciences, China, 科学技術振興事業団.
2012.10~2013.05, 1ヶ月以上, Fac.Of Vet.Medicine,Damanhour University, Egypt, Egypt, 外国政府・外国研究機関・国際機関.
2008.06~2009.09, 1ヶ月以上, Beni-Suef University., Egypt, 外国政府・外国研究機関・国際機関.
受賞
水産学進歩賞, 日本水産学会, 2009.03.
研究資金
科学研究費補助金の採択状況(文部科学省、日本学術振興会)
2018年度~2021年度, 基盤研究(B), 代表, 魚類リポカリンタンパク質―性分化機構を中心とした機能の解明.
2014年度~2016年度, 基盤研究(A), 分担, 有機性廃棄物の液肥利用とリサイクル・ループ構築に向けた国際共同研究.
2013年度~2014年度, 挑戦的萌芽研究, 代表, フグ毒結合タンパク質遺伝子ノックアウトによるトラフグ毒化機構の証明.
2012年度~2013年度, 挑戦的萌芽研究, 分担, 重油汚染海水で生まれた魚の脊柱彎曲の機構解明と新規解毒タンパク質によるレスキュー.
2012年度~2015年度, 基盤研究(A), 分担, 金属特異性を考慮した包括的な生態リスク評価手法の開発.
2011年度~2013年度, 基盤研究(B), 代表, 魚貝類の毒化機構を毒結合タンパク質の機能・進化から解明する.
2011年度~2012年度, 挑戦的萌芽研究, 代表, 特定化学物質PFOSの血液高蓄積機構の解明.
2008年度~2010年度, 基盤研究(C), 代表, 魚類の低分子結合性タンパク質ーリポカリンの大量発現と静菌活性に関する研究.
2005年度~2007年度, 基盤研究(B), 分担, 二枚貝(貝リンガル、貝メタボローム)を用いた沿岸生態系の影響評価.
2004年度~2005年度, 基盤研究(B), 分担, トリブチルスズを含む海底堆積汚泥中の地層処分に関する実用化研究.
2002年度~2003年度, 特定領域研究, 代表, PCBsが脳と行動に与える影 -メダカの群行動を通して脳の影響を解明する-.
2002年度~2004年度, 基盤研究(B), 分担, 有明海における貝類の激減と環境汚染物質の関する研究.
2001年度~2003年度, 基盤研究(B), 分担, 高次ホメオスタシス機能の化学環境依存性の解析.
2001年度~2001年度, 特定領域研究(A)特定領域研究(B), 代表, トリブチルスズとPCBsの複合作用による内分泌攪乱の解明.
1999年度~2000年度, 一般研究(C), 分担, 農業用水路の水理環境に対する魚群の応答行動とそのモデリングに関する研究.
1998年度~1999年度, 一般研究(C), 代表, 内分泌撹乱物質の複合汚染が水生生物の繁殖に及ぼす影響.
1998年度~1999年度, 一般研究(C), 分担, トリブチルスズは哺乳動物にとっても内分泌かく乱物質か?.
科学研究費補助金の採択状況(文部科学省、日本学術振興会以外)
2018年度~2020年度, 環境研究総合推進費, 分担, 海洋プラスチックごみ及びその含有化学物質による生態影響評価
サブテーマ:マイクロプラスチックの生物影響評価.
競争的資金(受託研究を含む)の採択状況
2019年度~2021年度, LRI, 代表, 劣化マイクロプラスチック由来吸着化学物質の体内動態モデルの構築と影響評価.
2016年度~2016年度, IST研究開発FS事業(シーズ育成枠), 分担, メダカの発音解析に基づく新規自動水質監視装置の開発.
2015年度~2015年度, 九州地域新産業戦略に基づくイノベーション創出事業― 機械工業振興チャレンジ研究調査, 代表, 水道原水および工場排水の安全性を担保するため: 魚の発音を用いた水質自動監視
システム企業化に関する調査研究.
2015年度~2015年度, 産業技術研究助成事業 (経済産業省), 代表, 平成27年度化学物質安全対策(肝S9を用いたin vitroによる生物蓄積性評価法に関する調査).
2005年度~2005年度, 独立行政法人 科学技術振興機構, 代表, 海産線虫を用いた迅速底質毒性評価(環境生物毒性評価)キットの開発.
2005年度~2005年度, 三重県地域結集型共同研究事業, 代表, 光補給技術の開発.
2004年度~2004年度, 科学技術振興機構, 代表, 海洋線虫による培養系を用いた底質の毒性評価法の開発.
2004年度~2004年度, 三重県地域結集型共同研究事業, 代表, ヘテロカプサ赤潮の被害防除技術の開発.
2004年度~2004年度, 三重県地域結集型共同研究事業, 代表, 底質への光・酸素補給技術の開発.
2003年度~2003年度, 三重県地域結集型共同研究事業, 代表, 環境調和型養殖技術の開発に関する研究.
共同研究、受託研究(競争的資金を除く)の受入状況
2020.06~2020.03, 代表, タイラギ飢餓ストレス遺伝子解析.
2019.06~2019.03, 代表, タイラギ飢餓ストレス遺伝子解.
2017.06~2018.03, 代表, タイラギ飢餓ストレス遺伝子解.
2016.06~2017.03, 代表, タイラギ飢餓ストレス遺伝子解.
2011.05~2012.03, 分担, 平成24年度漁場環境・生物多様性保全総合対策委託事業のうち赤潮・ 貧酸素水塊漁業被害防止対策事業(シャトネラ属有害プランクトンの魚介類への影響、毒性発現機構の解明、漁業被害防止・軽減技術に関する研究).
2010.07~2011.03, 分担, 沿岸生態系劣化における干潟生物の温暖化等環境負荷応答能力の解明.
2009.07~2010.03, 分担, 沿岸生態系劣化における干潟生物の温暖化等環境負荷応答能力の解明.
2007.05~2009.03, 分担, バイオセンサーによる室内空気質の毒性評価に関する研究.
2007.05~2008.03, 分担, 医薬品に関する生態影響評価法の確立.
2004.08~2005.02, 代表, 水産用医薬品に関する研究.
2003.12~2004.02, 代表, 水産用医薬品に関する研究.
2003.07~2004.03, 代表, 平成15年度先端技術を活用した農林水産研究高度化事業のうち「行政対応特別研究」.
2002.09~2003.03, 代表, 平成14年度先端技術を活用した農林水産研究高度化事業のうち「行政対応特別研究」「有明海における有害赤潮発生機構の解明」.
2002.09~2003.02, 代表, 水産用医薬品に関する研究.
2002.08~2003.03, 代表, 平成14年度「農林水産業における内分泌かく乱物質の動態解明と作用機構に関する総合研究」に関する委託事業.
2001.09~2002.03, 代表, 水産用医薬品に関する研究.
2001.10~2002.03, 代表, 有明海の海洋環境の変化が生物生産に及ぼす影響の解明.
2001.12~2002.03, 代表, 農林水産業における内分泌かく乱物質の動態解明と作用機構に関する総合研究 -すり身加工技術を利用した環境ホルモン除去法の開発-.

九大関連コンテンツ

pure2017年10月2日から、「九州大学研究者情報」を補完するデータベースとして、Elsevier社の「Pure」による研究業績の公開を開始しました。
 
 
九州大学知的財産本部「九州大学Seeds集」