| 1. |
EEG and long-term video EEG as clinical tools and research topics in the field of neurology
EEG can detect brain dysfunction which is difficult to be detected by neuroimages and blood tests, therefore it is effective in diagnosing epilepsy, sleep medicine, and disturbance of consciousness. It is clinically significant that EEG makes it possible to investigate the relationship between symptoms and EEG by recording videos simultaneously. Long-term video EEG monitoring is useful to detect abnormalities that could not be extracted by short-time conventional EEG recording. Due to development of digital technologies and higher performance amplifiers, EEG became possible to record high-frequency and low-frequency EEG activities with a long-time scale, and several new knowledges have been obtained in the research fields. New research fields have been expanding; such as utilizing EEG as long-term biological signal sensor, introduction of machine learning for EEG data analysis, and trial use as a telemedicine and educational tool. The usefulness of EEG in the field of neurology and several examples of EEG/long-term video EEG monitoring as promising research tools will be introduced in this section.. |
| 2. |
痙攣. |
| 3. |
Hiroshi Shigeto, Hippocampal modulation of auditory processing in epilepsy, 10.1111/ncn3.12470, 2020.11. |
| 4. |
てんかんの治療 : 薬物療法Update : Postガイドライン2018. |
| 5. |
生理検査レポートのみかた(第4回)脳波検査. |
| 6. |
Medical care of epilepsy faces to brain function
Anytime, medical care of epilepsy faces to brain function. Based on seizure semiology and findings of electroencephalography, we search for the excitable brain region and symptomatogenic zone in order to classify the seizure. Whether patient has impairment of consciousness during seizure is important not only for seizure classification but also patient’s social activity. Antiepileptic drugs are chosen based on epilepsy classification and the cause of epilepsy. Thirty to 40% of epilepsy patients are intractable against medication, which leads to increasing dose of antiepileptic drugs and induces brain dysfunction. As for intractable epilepsy, epilepsy surgery is considered. Best candidate for epilepsy surgery is medial temporal lobe epilepsy. There are memory problems before and after surgery in medial temporal lobe epilepsy. MRI negative neocortical epilepsy fails to poor outcome after epilepsy surgery, especially when the epileptogenic zone is estimated over eloquent area. Epilepsy patients feel difficulty not only from seizure itself. Stigma, brain dysfunction and inadequate therapy lead them to tragic life. To do the best and comprehensive medical care for epilepsy patients is important. This article introduces actual medical care facing to brain function with several epilepsy case presentations.. |
| 7. |
プレナリーセッション1 診療のスキルアップを考える : この症例をどう診るか2018. |
| 8. |
若年初発の強直間代発作の場合はJMEの可能性に注意する 若年性ミオクロニーてんかん(JME)に対する抗てんかん薬処方. |
| 9. |
Characteristics and Clinical Usefulness of New Antiepileptic Drugs. |
| 10. |
ミオクローヌスをきたすてんかん. |
| 11. |
心因性非てんかん性発作. |
| 12. |
H. Chatani, K. Hagiwara, K. Ogata, T. Uehara, H. Shigeto, N. Murakami, T. Morioka, J- Kira, S. Tobimatsu, FEASIBILITY OF AUDITORY EVOKED MAGNETIC FIELDS IN ESTIMATION OF EPILEPTOGENIC SIDE IN MESIAL TEMPORAL LOBE EPILEPSY, EPILEPSIA, Vol.54, pp.34-35, 2013.06. |
| 13. |
Yuji Kanamori, Noriko Isobe, Tomomi Yonekawa, Takuya Matsushita, Hiroshi Shigeto, Nobutoshi Kawamura, Ryo Yamasaki, Hiroyuki Murai, Shozo Tobimatsu, Jun-Ichi Kira, Multimodality evoked potentials for discrimination of atopic myelitis and multiple sclerosis, Clinical and Experimental Neuroimmunology, 10.1111/cen3.12018, Vol.4, No.1, pp.29-35, 2013.06, Objectives: To clarify the differences in multimodality evoked potential findings between patients with atopic myelitis (AM) and those with multiple sclerosis (MS). Methods: A retrospective chart review of 70 consecutive AM patients and 93 MS patients was carried out. All patients were negative for serum antiaquaporin- 4 antibody. Visual- (VEP), somatosensory- (SEP) and motor-evoked potentials (MEP) recorded at first examination, and magnetic resonance imaging (MRI) findings from the first examination were compared between AM and MS patients. Results: Compared with MS patients, AM patients showed male preponderance, lower the Expanded Disability Status Scale scores and less frequent spinal cord MRI lesions. Visual impairment and muscle weakness were also less severe in AM patients. Frequencies of abnormal VEP and prolonged central conduction time on lower limb MEP were significantly lower in AM patients than in MS patients (AM vs MS: 9.5% vs 55.6%, and 28.2% vs 54.4%, respectively), whereas frequencies of peripheral nerve involvement in upper and lower limb MEP and upper limb SEP were significantly higher in AM than in MS patients (AM vs MS: 12.8% vs 2.9%, 17.9% vs 2.9% and 33.3% vs 4.4%, respectively). When patients whose EP were examined within 5 years of disease onset were compared, lower frequencies of abnormal VEP and higher peripheral nerve involvement detected by MEP and SEP were observed in AM patients. Conclusions: AM patients have distinct physiological features compared with MS patients, even at the first examination of evoked potentials, which might suggest distinct immunological mechanisms between the two conditions. Multimodality evoked potentials might contribute to the early discrimination of these two disorders. © 2013 Japanese Society for Neuroimmunology.. |
| 14. |
脳波検査. |
| 15. |
新規抗てんかん薬の使い方. |
| 16. |
Autoantibody response targeting nodes and paranodes of ranvier in CIDP patients with CNS involvement. |
| 17. |
Novel Senataxin mutation (R2136C) in ALS4. |
| 18. |
湯通堂 紀子, 鎌田 崇嗣, 大西 陽子, 田, 大西 克典, 梶谷 康介, 作見 邦彦, 重藤 寛史, 中別府 雄作, fosB欠損マウスは成体海馬における神経新生の低下を示し、てんかんを自然発症する(fosB-null mice exhibit impaired adult hippocampal neurogenesis and spontaneous epileptic seizures), 神経化学, Vol.49, No.2-3, p.753, 2010.08. |
| 19. |
A case of acute disseminated encephalomyelitis associated with Epstein-Barr virus reactivation during infliximab therapy
症例は31歳女性である。クローン病に対してインフリキシマブ投与開始11ヵ月後に無菌性髄膜炎を発症し一時軽快したが、その後に体幹失調や球麻痺が出現した。髄液検査では単核球優位の細胞数増多、ミエリン塩基性蛋白とIgG indexが上昇しており血清のEpstein-Barrウイルス(EBV)抗体は既感染パターンを示し、髄液・血液PCRにてEBV-DNAを検出した。MRIにて脳幹、大脳皮質下白質、頸髄に散在性にT2高信号病変をみとめ急性散在性脳脊髄炎(ADEM)と診断した。各種免疫治療に抵抗性であったが、ステロイドパルス療法を反復し症状は改善した。抗TNF-α抗体製剤の副作用による脱髄が報告されているが、本症例は抗TNF-α抗体製剤投与中のEBV再活性化によって惹起されたADEMと考えられた。(著者抄録). |
| 20. |
銅欠乏による末梢神経障害、脊髄症、潜在的視神経症をきたした1例. |
| 21. |
Phase-locking analysis of somatosensory cortical network in the human brain. |
| 22. |
高瀬 敬一郎, 重藤 寛史, 鎌田 崇嗣, 大八木 保政, 吉良 潤一, ラット皮質てんかんモデルにおける視床背内側核刺激の検討(Efficacy of mediodorsal thalamic nucleus stimulation in a rat model of cortical seizure), てんかん研究, Vol.27, No.2, p.323, 2009.09. |
| 23. |
O1-40 Epileptogenesis of the intractable epilepsy with MR visible lesion near the parieto-occipital sulcus(The 42^ Congress of the Japan Epilepsy Society). |
| 24. |
O2-69 Radiation-induced multiple cavernoma presenting with epilepsy : a report of two cases(The 42^ Congress of the Japan Epilepsy Society). |
| 25. |
Kei-ichiro Takase, Takashi Kamada, Hiroshi Shigeto, Satoshi O. Suzuki, Jun-ichi Kira, Prenatal freeze lesioning produces epileptogenic focal cortical dysplasia, NEUROLOGY, Vol.70, No.11, p.A455, 2008.03. |
| 26. |
O1-27 Diagnositic value of video-EEG monitoring within 48 hours in patients with MTLE(The 41^ | Congress of the Japan Epilepsy Society).
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| 27. |
O2-28 A case of Neuro-Sweet disease presenting recurrent meningoencephalitis and temporal lobe epilepsy(The 41^ | Congress of the Japan Epilepsy Society).
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| 28. |
O2-29 A case of and GAD Ab positive stiff-person syndrome, who showed oral automatism as initial symptom(The 41^ | Congress of the Japan Epilepsy Society).
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| 29. |
P2-06 A study for suppression of epileptic seizure using cooling device on rat neck(The 41^ Congress of the Japan Epilepsy Society). |
| 30. |
抗てんかん薬治療により軽快する記憶障害を呈した一例. |
| 31. |
O1-07 System integration of Epilepsy video-EEG monitoring in Kyusyu University hospital(The 40th Congress of the Japan Epilepsy Society). |
| 32. |
O2-18 A study for the epileptogenesis of focal cortical dysplasia induced during rat embryonic state(The 40th Congress of the Japan Epilepsy Society). |
| 33. |
O2-24 Investigation of the epilepsy patients without EEG and MRI abnormality(The 40th Congress of the Japan Epilepsy Society). |
| 34. |
O1-07 System integration of Epilepsy video-EEG monitoring in Kyusyu University hospital(The 40th Congress of the Japan Epilepsy Society). |
| 35. |
O2-18 A study for the epileptogenesis of focal cortical dysplasia induced during rat embryonic state(The 40th Congress of the Japan Epilepsy Society). |
| 36. |
O2-24 Investigation of the epilepsy patients without EEG and MRI abnormality(The 40th Congress of the Japan Epilepsy Society). |
| 37. |
症例報告 頸動脈海綿静脈洞瘻を有し静脈性脳梗塞を生じた1例. |
| 38. |
症例報告 頸動脈海綿静脈洞瘻を有し静脈性脳梗塞を生じた1例. |
| 39. |
症例報告 多発性脳梗塞を呈した若年女性の脳底動脈fibromuscular dysplasiaの1例. |
| 40. |
症例報告 多発性脳梗塞を呈した若年女性の脳底動脈fibromuscular dysplasiaの1例. |
| 41. |
本田 陽子[大西], 大西 克典, 高瀬 敬一郎, 石橋 仁, 江藤 圭, 梶谷 康介, 作見 邦彦, 後藤 純信, 野田 百美, 重藤 寛史, 中別府 雄作, δFosBはカイニン酸により引き起こされる興奮毒性に対する抵抗性を決めている(δFosB determines resistance to excitotoxicity induced by kainic acid), 神経化学, Vol.44, No.2-3, p.186, 2005.08. |
| 42. |
本田 陽子[大西], 大西 克典, 高瀬 敬一郎, 石橋 仁, 江藤 圭, 梶谷 康介, 作見 邦彦, 後藤 純信, 野田 百美, 重藤 寛史, 中別府 雄作, δFosBはカイニン酸により引き起こされる興奮毒性に対する抵抗性を決めている(δFosB determines resistance to excitotoxicity induced by kainic acid), 神経化学, Vol.44, No.2-3, p.186, 2005.08. |
| 43. |
Myoloradiculoneuropathy associated to bronchial asthma. |
| 44. |
Myoloradiculoneuropathy associated to bronchial asthma. |
| 45. |
症例報告 椎骨脳底動脈・後大脳動脈領域に限局した若年性多発脳梗塞の1例
A 29-year-old woman had continuous remittent fever after cesarean section. The debridement of operation scar and drainage were performed. But remittent fever still lasted and white blood cell count and CRP increased furthermore. The microorganisms were not detected in her ascites and arterial blood by culture system. The levels of inflammatory cytokines such as interleukin-6 and TNF-α in serum were elevated to 1, 300pg/ml and 50pg/ml, respectively. So, continuous hemodiafiltration(CHDF)was done under a diagnosis of systemic inflammatory response syndrome(SIRS). After CHDF for two days, the inflammatory cytokines decreased dramatically and the general findings of the patients recovered rapidly.. |
| 46. |
症例報告 椎骨脳底動脈・後大脳動脈領域に限局した若年性多発脳梗塞の1例
A 29-year-old woman had continuous remittent fever after cesarean section. The debridement of operation scar and drainage were performed. But remittent fever still lasted and white blood cell count and CRP increased furthermore. The microorganisms were not detected in her ascites and arterial blood by culture system. The levels of inflammatory cytokines such as interleukin-6 and TNF-α in serum were elevated to 1, 300pg/ml and 50pg/ml, respectively. So, continuous hemodiafiltration(CHDF)was done under a diagnosis of systemic inflammatory response syndrome(SIRS). After CHDF for two days, the inflammatory cytokines decreased dramatically and the general findings of the patients recovered rapidly.. |
| 47. |
エストリオール上昇及び女性化乳房を呈したミトコンドリア脳筋症の一例. |
| 48. |
エストリオール上昇及び女性化乳房を呈したミトコンドリア脳筋症の一例. |
| 49. |
シェーグレン症候群に合併した感覚失調性ニューロパチーで,亜急性増悪の自然軽快をみとめた1例. |
| 50. |
シェーグレン症候群に合併した感覚失調性ニューロパチーで,亜急性増悪の自然軽快をみとめた1例. |
| 51. |
Painful unilateral gynecomastia in a patient with myotonic dystrophy. |
| 52. |
Juvenile parkinsonism with symmetrical hypoperfusion in the cerebellum : A case report. |
| 53. |
Painful unilateral gynecomastia in a patient with myotonic dystrophy. |
| 54. |
Overloading to neck extensor muscles is an aggravating factor to induce further neck drop in isolated neck extensor myopathy (Katz). A case report. |
| 55. |
Overloading to neck extensor muscles is an aggravating factor to induce further neck drop in isolated neck extensor myopathy (Katz). A case report. |
| 56. |
Beneficial effect of eyelid make-up (natural rubber latex) to induce a new fold in the treatment of blepharoptosis in myotonic dystrophy. |
| 57. |
菊池 仁志, 山田 猛, 岡山 晶, 原 英夫, 谷脇 考恭, 重藤 寛史, 佐々木 雅之, 岩城 徹, 吉良 潤一, 胃神経内分泌腫瘍に合併したオプソクローヌスを伴わない抗Ri抗体陽性の腫瘍随伴性小脳変性症の1例, 福岡医学雑誌, Vol.91, No.4, pp.104-109, 2000.04, 63歳男,神経学的には,重度の小脳失調症状のみで,オプソクローヌスは見られなかった.胃癌は,組織学的には低分化型腺癌と神経内分泌腫瘍の両者の成分より形成されており,患者血清を用いた免疫組織化学では後者の細胞の核が強く染色され,ウエスタンブロット法で組換え型Ri抗原に反応を認めた. |
| 58. |
菊池 仁志, 山田 猛, 岡山 晶, 原 英夫, 谷脇 考恭, 重藤 寛史, 佐々木 雅之, 岩城 徹, 吉良 潤一, 胃神経内分泌腫瘍に合併したオプソクローヌスを伴わない抗Ri抗体陽性の腫瘍随伴性小脳変性症の1例, 福岡医学雑誌, Vol.91, No.4, pp.104-109, 2000.04, 63歳男,神経学的には,重度の小脳失調症状のみで,オプソクローヌスは見られなかった.胃癌は,組織学的には低分化型腺癌と神経内分泌腫瘍の両者の成分より形成されており,患者血清を用いた免疫組織化学では後者の細胞の核が強く染色され,ウエスタンブロット法で組換え型Ri抗原に反応を認めた. |
| 59. |
A case of Lyme disease with the triad of neurologic manifestations (meningitis, radiculoneuritis, facial nerve palsy) and dermatitis of the nail roots. |
| 60. |
A case of Lyme disease with the triad of neurologic manifestations (meningitis, radiculoneuritis, facial nerve palsy) and dermatitis of the nail roots. |
| 61. |
A case of Hopkins syndrome with onset at puberty.. |
| 62. |
A case of Hopkins syndrome with onset at puberty.. |
| 63. |
A case of bilateral brachial plexopathy after median sternotomy. |
| 64. |
A case of bilateral brachial plexopathy after median sternotomy. |
