| 1. |
Keisuke Abe, Takafumi Shimogawa, Nobutaka Mukae, Koumei Ikuta, Tadahisa Shono, Atsuo Tanaka, Ayumi Sakata, Hiroshi Shigeto, Koji Yoshimoto, Takato Morioka, Detection of ictal and periictal hyperperfusion with subtraction of ictal-interictal 1.5-Tesla pulsed arterial spin labeling images co-registered to conventional magnetic resonance images (SIACOM)., Surgical neurology international, 10.25259/SNI_723_2022, 14, 84-84, 2023.03, BACKGROUND: Our recent report showed that 1.5-T pulsed arterial spin labeling (ASL) magnetic resonance (MR) perfusion imaging (1.5-T Pulsed ASL [PASL]), which is widely available in the field of neuroemergency, is useful for detecting ictal hyperperfusion. However, the visualization of intravascular ASL signals, namely, arterial transit artifact (ATA), is more remarkable than that of 3-T pseudocontinuous ASL and is easily confused with focal hyperperfusion. To eliminate ATA and enhance the detectability of (peri) ictal hyperperfusion, we developed the subtraction of ictal-interictal 1.5-T PASL images co-registered to conventional MR images (SIACOM). METHODS: We retrospectively analyzed the SIACOM findings in four patients who underwent ASL during both (peri) ictal and interictal states and examined the detectability for (peri) ictal hyperperfusion. RESULTS: In all patients, the ATA of the major arteries was almost eliminated from the subtraction image of the ictal-interictal ASL. In patients 1 and 2 with focal epilepsy, SIACOM revealed a tight anatomical relationship between the epileptogenic lesion and the hyperperfusion area compared with the original ASL image. In patient 3 with situation-related seizures, SIACOM detected minute hyperperfusion at the site coinciding with the abnormal electroencephalogram area. SIACOM of patient 4 with generalized epilepsy diagnosed ATA of the right middle cerebral artery, which was initially thought to be focal hyperperfusion on the original ASL image. CONCLUSION: Although it is necessary to examine several patients, SIACOM can eliminate most of the depiction of ATA and clearly demonstrate the pathophysiology of each epileptic seizure.. |
| 2. |
Toshiki Okadome, Takahiro Yamaguchi, Takahiko Mukaino, Ayumi Sakata, Katsuya Ogata, Hiroshi Shigeto, Noriko Isobe, Taira Uehara, The effect of interictal epileptic discharges and following spindles on motor sequence learning in epilepsy patients., Frontiers in neurology, 10.3389/fneur.2022.979333, 13, 979333-979333, 2022.11, PURPOSE: Interictal epileptic discharges (IEDs) are known to affect cognitive function in patients with epilepsy, but the mechanism has not been elucidated. Sleep spindles appearing in synchronization with IEDs were recently demonstrated to impair memory consolidation in rat, but this has not been investigated in humans. On the other hand, the increase of sleep spindles at night after learning is positively correlated with amplified learning effects during sleep for motor sequence learning. In this study, we examined the effects of IEDs and IED-coupled spindles on motor sequence learning in patients with epilepsy, and clarified their pathological significance. MATERIALS AND METHODS: Patients undergoing long-term video-electroencephalography (LT-VEEG) at our hospital from June 2019 to November 2021 and age-matched healthy subjects were recruited. Motor sequence learning consisting of a finger-tapping task was performed before bedtime and the next morning, and the improvement rate of performance was defined as the sleep-dependent learning effect. We searched for factors associated with the changes in learning effect observed between the periods of when antiseizure medications (ASMs) were withdrawn for LT-VEEG and when they were returned to usual doses after LT-VEEG. RESULTS: Excluding six patients who had epileptic seizures at night after learning, nine patients and 11 healthy subjects were included in the study. In the patient group, there was no significant learning effect when ASMs were withdrawn. The changes in learning effect of the patient group during ASM withdrawal were not correlated with changes in sleep duration or IED density; however, they were significantly negatively correlated with changes in IED-coupled spindle density. CONCLUSION: We found that the increase of IED-coupled spindles correlated with the decrease of sleep-dependent learning effects of procedural memory. Pathological IED-coupled sleep spindles could hinder memory consolidation, that is dependent on physiological sleep spindles, resulting in cognitive dysfunction in patients with epilepsy.. |
| 3. |
山口高弘、重藤寛史, 日常臨床で遭遇する治療可能な認知症・認知症様状態 てんかん, 臨床と研究, 99, 99, 32-36, 2022.11. |
| 4. |
三好絢子, 田中秀明, 鎌田崇嗣, 萩原綱一, 大原信司, 重藤寛史, 赤松直樹, 高血糖が誘因でてんかん重積状態となった側頭葉てんかん術後の一例, Journal of Japan Society of Neurological Emergencies & Critical Care (Web), 35, 1, 2022.11. |
| 5. |
Takahiko Mukaino, Taira Uehara, Jun Yokohama, Toshiki Okadome, Tomomi Arakawa, Setsu Yokoyama, Ayumi Sakata, Kei-Ichiro Takase, Osamu Togao, Naoki Akamatsu, Hiroshi Shigeto, Noriko Isobe, Jun-Ichi Kira, Atrophy of the hippocampal CA1 subfield relates to long-term forgetting in focal epilepsy., Epilepsia, 10.1111/epi.17378, 63, 10, 2623-2636, 2022.10, OBJECTIVE: The mechanisms underlying accelerated long-term forgetting (ALF) in patients with epilepsy are still under investigation. We examined the contribution of hippocampal subfields and their morphology to long-term memory performance in patients with focal epilepsy. METHODS: We prospectively assessed long-term memory and performed magnetic resonance imaging in 80 patients with focal epilepsy (61 with temporal lobe epilepsy and 19 with extratemporal lobe epilepsy) and 30 healthy controls. The patients also underwent electroencephalography recording. Verbal and visuospatial memory was tested 30 s, 10 min, and 1 week after learning. We assessed the volumes of the whole hippocampus and seven subfields and deformation of the hippocampal shape. The contributions of the hippocampal volumes and shape deformation to long-term forgetting, controlling for confounding factors, including the presence of interictal epileptiform discharges, were assessed by multiple regression analyses. RESULTS: Patients with focal epilepsy had lower intelligence quotients and route recall scores at 10 min than controls. The focal epilepsy group had smaller volumes of both the right and left hippocampal tails than the control group, but there were no statistically significant group differences for the volumes of the whole hippocampus or other hippocampal subfields. Multiple regression analyses showed a significant association between the left CA1 volume and the 1-week story retention (β = 7.76; Bonferroni-corrected p = 0.044), but this was not found for the whole hippocampus or other subfield volumes. Hippocampal shape analyses revealed that atrophy of the superior-lateral, superior-central, and inferior-medial regions of the left hippocampus, corresponding to CA1 and CA2/3, was associated with the verbal retention rate. SIGNIFICANCE: Our results suggest that atrophy of the hippocampal CA1 region and its associated structures disrupts long-term memory consolidation in focal epilepsy. Neuronal cell loss in specific hippocampal subfields could be a key underlying cause of ALF in patients with epilepsy.. |
| 6. |
上原 平, 向野 隆彦, 岡留 敏樹, 迎 伸孝, 酒田 あゆみ, 重藤 寛史, 飛松 省三, 村井 弘之, 海馬発作間欠期てんかん性放電は前頭部に睡眠紡錘波を誘発する, 臨床神経生理学, 50, 5, 377-377, 2022.10. |
| 7. |
山口 高弘, 岡留 敏樹, 向野 隆彦, 上原 平, 下川 能史, 重藤 寛史, 磯部 紀子, 突発性のてんかん性放電とは異なるてんかん性脳波異常を機械学習にて検出する試み, 臨床神経生理学, 50, 5, 403-403, 2022.10. |
| 8. |
宇佐美清英, 赤松直樹, 飯村康司, 井内盛遠, 今村久司, 榎日出夫, 木下真幸子, 國井尚人, 小林勝弘, 小林勝哉, 酒田あゆみ, 重藤寛史, 下竹昭寛, 神一敬, 菅野秀宣, 田中章浩, 千葉茂, 寺田清人, 飛松省三, 夏目淳, 原恵子, 人見健文, 本多正幸, 前原建寿, 松本理器, 三枝隆博, 矢部博興, 山野光彦, 池田昭夫, 臨床脳波の諸問題に関する情報共有と提言 -脳波セミナー・アドバンスコース小委員会レポート-, 臨床神経生理学(Web), 50, 3, 2022.10. |
| 9. |
Tasuku Sato, Ichiro Sakamoto, Ken-ichi Hiasa, Masateru Kawakubo, Ayako Ishikita, Shintaro Umemoto, Min-Jeong Kang, Hiroyuki Sawatari, Akiko Chishaki, Hiroshi Shigeto, Hiroyuki Tsutsui, High-echoic line tracing of transthoracic echocardiography accurately assesses right ventricular enlargement in adult patients with atrial septal defect, INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING, 10.1007/s10554-022-02712-x, 39, 1, 87-95, 2022.08, Accurate measurement of right ventricular (RV) size using transthoracic echocardiography (TTE) is important for evaluating the severity of congenital heart diseases. The RV end-diastolic area index (RVEDAi) determined using TTE is used to assess RV dilatation; however, the tracing line of the RVEDAi has not been clearly defined by the guidelines. This study aimed to determine the exact tracing method for RVEDAi using TTE. We retrospectively studied 107 patients with atrial septal defects who underwent cardiac magnetic resonance imaging (CMR) and TTE. We measured the RVEDAi according to isoechoic and high-echoic lines, and compared it with the RVEDAi measured using CMR. The isoechoic line was defined as the isoechoic endocardial border of the RV free wall, whereas the high-echoic line was defined as the high-echoic endocardial border of the RV free wall more outside than the isoechoic line. RVEDAi measured using high-echoic line (high-RVEDAi) was more accurately related to RVEDAi measured using CMR than that measured using isoechoic line (iso-RVEDAi). The difference in the high-RVEDAi was 0.3 cm(2)/m(2), and the limit of agreement (LOA) was - 3.7 to 4.3 cm(2)/m(2). With regard to inter-observer variability, high-RVEDAi was superior to iso-RVEDAi. High-RVEDAi had greater agreement with CMR-RVEDAi than with iso-RVEDAi. High-RVEDAi can become the standard measurement of RV size using two-dimensional TTE.. |
| 10. |
岡留 敏樹, 山口 高弘, 向野 隆彦, 渡邊 恵利子, 酒田 あゆみ, 下川 能史, 迎 伸孝, 森岡 隆人, 磯部 紀子, 重藤 寛史, 慢性硬膜下電極記録に対し畳み込みニューラルネットワークを用いて行ったてんかん原性領域の自動推定, てんかん研究, 40, 2, 411-411, 2022.08. |
| 11. |
向野 隆彦, 山口 高弘, 岡留 敏樹, 山田 絵美, 太田 真理, 三笘 良, 光藤 崇子, 田村 俊介, 平野 羊嗣, 栂尾 理, 萩原 綱一, 磯部 紀子, 重藤 寛史, 海馬回旋異常における構造的MRIの特徴の検討, てんかん研究, 40, 2, 440-440, 2022.08. |
| 12. |
宇佐美 清英, 赤松 直樹, 飯村 康司, 井内 盛遠, 今村 久司, 榎 日出夫, 木下 真幸子, 國井 尚人, 小林 勝弘, 小林 勝哉, 酒田 あゆみ, 重藤 寛史, 下竹 昭寛, 神 一敬, 菅野 秀宣, 田中 章浩, 千葉 茂, 寺田 清人, 飛松 省三, 夏目 淳, 原 恵子, 人見 健文, 本多 正幸, 前原 建寿, 松本 理器, 三枝 隆博, 矢部 博興, 山野 光彦, 池田 昭夫, 臨床脳波の諸問題に関する情報共有と提言 脳波セミナー・アドバンスコース小委員会レポート, 臨床神経生理学, 10.11422/jscn.50.107, 50, 3, 107-112, 2022.06, 臨床神経生理学会が主催し, 臨床脳波の専門的知識・技術習得を目的とした脳波セミナー・アドバンスコースは2020年で5回を数えた。この経験を踏まえ, 本邦の臨床神経生理学の臨床・教育・研究の発展に係る問題点と方向性をまとめた。未だ臨床実用段階ではないが, 今後, 臨床脳波は情報通信技術とAI (artificial intelligence) の発展・活用が期待される。同時に, 脳波判読にかかる各科の医師, 技師の養成を継続しつつ, 脳波報告書の解釈の標準化や, ICU (intensive care unit) での長時間脳波モニタを含む脳波保険点数加算の要望など, 脳波学を一般臨床へ還元できる体制を整えていく必要がある。脳波教育・研究の発展に関し, 国内外の関連学会と協力する余地がある。そして, 基礎と実践 (ハンズオン) の教育機会の均てん化のため, Webの活用や各地域で講師育成を行って最適化する必要がある。また, 生涯教育, ICU専従医師などさまざまなキャリアを持つ医療者向けに教育対象を広げるのが望ましい。. |
| 13. |
Naoto Kuroda, Takafumi Kubota, Toru Horinouchi, Naoki Ikegaya, Yu Kitazawa, Satoshi Kodama, Izumi Kuramochi, Teppei Matsubara, Naoto Nagino, Shuichiro Neshige, Temma Soga, Yutaro Takayama, Daichi Sone, Kousuke Kanemoto, Akio Ikeda, Kiyohito Terada, Hiroko Goji, Shinji Ohara, Koichi Hagiwara, Takashi Kamada, Koji Iida, Nobutsune Ishikawa, Hideaki Shiraishi, Osato Iwata, Hidenori Sugano, Yasushi Iimura, Takuichiro Higashi, Hiroshi Hosoyama, Ryosuke Hanaya, Akihiro Shimotake, Takayuki Kikuchi, Takeshi Yoshida, Hiroshi Shigeto, Jun Yokoyama, Takahiko Mukaino, Masaaki Kato, Masanori Sekimoto, Masahiro Mizobuchi, Yoko Aburakawa, Masaki Iwasaki, Eiji Nakagawa, Tomohiro Iwata, Kentaro Tokumoto, Takuji Nishida, Yukitoshi Takahashi, Kenjiro Kikuchi, Ryuki Matsuura, Shin-Ichiro Hamano, Ayataka Fujimoto, Hideo Enoki, Kyoichi Tomoto, Masako Watanabe, Youji Takubo, Toshihiko Fukuchi, Hidetoshi Nakamoto, Yuichi Kubota, Naoto Kunii, Yuichiro Shirota, Eiichi Ishikawa, Nobukazu Nakasato, Taketoshi Maehara, Motoki Inaji, Shunsuke Takagi, Takashi Enokizono, Yosuke Masuda, Takahiro Hayashi, Impact of COVID-19 pandemic on epilepsy care in Japan: A national-level multicenter retrospective cohort study., Epilepsia open, 10.1002/epi4.12616, 7, 3, 431-41, 2022.05, OBJECTIVE: The impact of the coronavirus disease 2019 (COVID-19) pandemic on epilepsy care across Japan was investigated by conducting a multicenter retrospective cohort study. METHODS: This study included monthly data on the frequency of (1) visits by outpatients with epilepsy, (2) outpatient electroencephalography (EEG) studies, (3) telemedicine for epilepsy, (4) admissions for epilepsy, (5) EEG monitoring, and (6) epilepsy surgery in epilepsy centers and clinics across Japan between January 2019 and December 2020. We defined the primary outcome as epilepsy-center-specific monthly data divided by the 12-month average in 2019 for each facility. We determined whether the COVID-19 pandemic-related factors (such as year [2019 or 2020], COVID-19 cases in each prefecture in the previous month, and the state of emergency) were independently associated with these outcomes. RESULTS: In 2020, the frequency of outpatient EEG studies (-10.7%, p |
| 14. |
Yonamoto A, Mukae N, Shimogawa T, Uehara T, Shigeto H, Sakata A, Mizoguchi M, Yoshimoto K, Morioka T., Good seizure outcome after focal resection surgery for super-refractory status epilepticus: Report of two cases., Surg Neurol Int., 10.25259/SNI_152_2022, 13, 165, 2022.04. |
| 15. |
Naoto Kuroda1,2$*, Takayuki Iwayama1,3,4$, Takafumi Kubota1,5, Toru Horinouchi1,6, Naoki Ikegaya1,7*, Yu Kitazawa1,8, Satoshi Kodama1,9, Teppei Matsubara1,10, Naoto Nagino1,11, Shuichiro Neshige1,12, Temma Soga1,13, Daichi Sone1,14, Yutaro Takayama1,15, Izumi Kuramochi1,3, IMPACT-J EPILEPSY (In-depth Multicenter analysis during Pandemic of Covid19 Throughout Japan for Epilepsy practice) study group†
(Group member), Post-hoc analysis of a cross-sectional nationwide survey assessing psychological distress in electroencephalography technicians during the COVID-19 pandemic in Japan: Qualitative and quantitative text analysis of open-ended response data, Epilepsy & Seizure, 14, 1, 51-63, 2022.04. |
| 16. |
Toshiki Okadome, Hajime Takeuchi, Takahiro Yamaguchi, Takahiko Mukaino, Hidenori Ogata, Katsuhisa Masaki, Hiroshi Shigeto, Noriko Isobe, Shadowboxing-induced reflex seizures in a patient with focal epilepsy., Epilepsy & behavior reports, 10.1016/j.ebr.2022.100543, 19, 100543-100543, 2022.04, Exercise-induced reflex seizures are a rare form of reflex seizures that are exclusively induced by a specific type of exercise. Many patients with exercise-induced reflex seizures exhibit drug-resistance, and are therefore advised to avoid the triggering exercise. Here, we describe a focal epilepsy patient with shadowboxing-induced reflex seizures. His semiology included focal aware seizures with speech and behavioral arrest that evolved to head version to the right, preceded by cephalic aura. We identified a specific motion that induced these seizures during shadowboxing using video-electroencephalographic recording, and the patient was able to continue boxing by avoiding this motion. We speculate that a broad brain network may be the pathological substrate of his exercise-induced reflex seizures. Identification of the specific motion that induces exercise-induced reflex seizures is useful for not only understanding the underlying pathophysiology, but also for minimizing the therapeutic restriction of the exercise.. |
| 17. |
Eriko Watanabe, Nobutaka Mukae, Ayumi Sakata, Takafumi Shimogawa, Hiroshi Shigeto, Taeko Hotta, Dongchong Kang, Koji Yoshimoto, Takato Morioka, High frequency oscillation analysis of intracranial 14 and 6 Hz-positive spikes and interictal epileptiform discharges in a patient with occipital lobe epilepsy, Epilepsy and seizure, 14, 1, 10-16, 2022.04. |
| 18. |
Koichi Hagiwara, Takashi Kamada, Satoshi O Suzuki, Ayako Miyoshi, Hideaki Tanaka, Hiroshi Shigeto, Shinji Ohara, Naoki Akamatsu, Stereo-electroencephalography evidence of an eccentrically located seizure-onset zone around a polymorphous low-grade neuroepithelial tumor of the young: illustrative case., Journal of neurosurgery. Case lessons, 10.3171/CASE22106, 3, 17, 2022.04, BACKGROUND: Polymorphous low-grade neuroepithelial tumor of the young (PLNTY) is a newly identified low-grade brain tumor with frequent epileptic presentation. Despite the facilitated use of invasive electroencephalography owing to the growing availability of stereo-electroencephalography (SEEG), intracranial features of tumor-related seizures are still scarcely described. This report provides the first description of SEEG-recorded seizures in PLNTY to provide an insight into its surgical strategy. OBSERVATIONS: Spontaneous clinical seizures were recorded with SEEG in a young adult patient with drug-resistant epilepsy associated with a PLNTY in the left lateral temporal cortex. The seizure onset was characterized by low-voltage fast activity (LVFA) and showed eccentric localization with respect to the tumor: LVFA was localized in the anterior portion of the tumor and spread toward the adjacent polar cortex. The language risks associated with the resection of the posterior temporal cortex could thus be minimized. LESSONS: PLNTY can show a focal and eccentric seizure-onset zone around the tumor. The present findings serve to improve the functional and seizure outcomes using the staged invasive approach in PLNTY.. |
| 19. |
Katsuhiro Goto, Takafumi Shimogawa, Nobutaka Mukae, Tadahisa Shono, Fujio Fujiki, Atsuo Tanaka, Ayumi Sakata, Hiroshi Shigeto, Koji Yoshimoto, Takato Morioka, Implications and limitations of magnetic resonance perfusion imaging with 1.5-Tesla pulsed arterial spin labeling in detecting ictal hyperperfusion during non-convulsive status epileptics., Surgical neurology international, 10.25259/SNI_841_2021, 13, 147-147, 2022.03, Background: Recent our reports showed that 3-T pseudocontinuous arterial spin labeling (3-T pCASL) magnetic resonance perfusion imaging with dual post labeling delay (PLD) of 1.5 and 2.5 s clearly demonstrated the hemodynamics of ictal hyperperfusion associated with non-convulsive status epilepticus (NCSE). We aimed to examine the utility of 1.5-T pulsed arterial spin labeling (1.5-T PASL), which is more widely available for daily clinical use, for detecting ictal hyperperfusion. Methods: We retrospectively analyzed the findings of 1.5-T PASL with dual PLD of 1.5 s and 2.0 s in six patients and compared the findings with ictal electroencephalographic (EEG) findings. Results: In patients 1 and 2, we observed the repeated occurrence of ictal discharges (RID) on EEG. In patient 1, with PLDs of 1.5 s and 2.0 s, ictal ASL hyperperfusion was observed at the site that matched the RID localization. In patient 2, the RID amplitude was extremely low, with no ictal ASL hyperperfusion. In patient 3 with lateralized periodic discharges (LPD), we observed ictal ASL hyperperfusion at the site of maximal LPD amplitude, which was apparent at a PLD of 2.0 s but not 1.5 sec. Among three patients with rhythmic delta activity (RDA) of frequencies |
| 20. |
Koichi Hagiwara, Hideaki Tanaka, Ayako Miyoshi, Takashi Kamada, Hiroshi Shigeto, Shinji Ohara, Naoki Akamatsu, Postoperative striatal degeneration: a hitherto unrecognized impact of frontal disconnection surgery for drug-resistant epilepsy. Illustrative cases., Journal of neurosurgery. Case lessons, 10.3171/CASE21644, 3, 9, 2022.02, BACKGROUND: Frontal disconnection surgery is a useful surgical option for patients with frontal epilepsy whose seizure onset zones are exceedingly large and thus are not amenable to conventional resective surgery. While it has the advantage of avoiding sequelae stemming from a large resection cavity, the impact of radical anatomofunctional disconnection of such a vast frontal region is not fully understood. OBSERVATIONS: The authors have identified secondary degeneration in the striatum ipsilateral to the frontal disconnection surgery in two adult patients who had otherwise favorable postoperative outcomes following the surgery. On serial postoperative magnetic resonance imaging, the striatum showed transient restricted diffusion in the caudate head and rostral putamen around several weeks postoperatively and subsequent atrophy in the caudate head. The affected striatal regions (i.e., the anterior portion of the striatum) were congruent with the known fronto-striatal connectivity corresponding to the disconnected frontal regions anterior to the primary and supplementary motor areas. Both patients achieved 1-year seizure freedom without apparent disability related to the surgery. LESSONS: The benign postoperative course despite the marked degenerative changes in the ipsilateral striatum supports the feasibility of the frontal disconnection surgery in otherwise inoperable patients with broad frontal epileptogenicity.. |
| 21. |
Ayumi Sakata, Nobutaka Mukae, Takato Morioka, Shunya Tanaka, Takafumi Shimogawa, Hiroshi Shigeto, Taeko Hotta, Dongchong Kang, Masahiro Mizoguchi, Simultaneous Electroencephalographic and Electocorticographic Recordings of Lateralized Periodic Discharges in Temporal Lobe Epilepsy., Clinical EEG and neuroscience, 10.1177/1550059420972266, 53, 1, 61-69, Online ahead of print, 2022.01, 片側性周期性放電を頭蓋内外で記録して比較した。. |
| 22. |
Ayako Motoki, Naoki Akamatsu, Tomoyuki Fumuro, Ayako Miyoshi, Hideaki Tanaka, Koichi Hagiwara, Shinji Ohara, Takashi Kamada, Hiroshi Shigeto, Hiroyuki Murai, Characteristics of olfactory dysfunction in patients with temporal lobe epilepsy., Epilepsy & behavior : E&B, 10.1016/j.yebeh.2021.108402, 125, 108402-108402, 2021.12, OBJECTIVE: To determine the characteristics of olfactory dysfunction in patients with temporal lobe epilepsy (TLE). METHODS: Odor identification was assessed using the odor stick identification test for Japanese (OSIT-J, full score 12 points) in 65 patients with TLE and in 74 controls. RESULTS: The mean OSIT-J score was significantly lower in patients with TLE (mean ± SD = 8.1 ± 2.8; median = 9) than in the control subjects (mean ± SD = 10.6 ± 1.1; median = 11) (P |
| 23. |
Ayako Motoki, Naoki Akamatsu, Tomoyuki Fumuro, Ayako Miyoshi, Hideaki Tanaka, Koichi Hagiwara, Shinji Ohara, Takashi Kamada, Hiroshi Shigeto, Hiroyuki Murai, Comparison of Acute Withdrawal and Slow Taper of Antiseizure Medications during Video Electroencephalographic Monitoring: Efficacy for Shortening of Hospital Stay., Journal of clinical medicine, 10.3390/jcm10245972, 10, 24, 2021.12, Antiepileptic medications (ASMs) are withdrawn at the epilepsy monitoring unit to facilitate seizure recordings. The effect of rapid tapering of ASMs on the length of hospital stay has not been well documented. We compared the mean length of hospital stay between patients who underwent acute ASM withdrawal and slow dose tapering during long-term video electroencephalography (EEG) monitoring. We retrospectively investigated 57 consecutive patients admitted to the epilepsy monitoring unit regarding the mean length of hospital stay in the acute ASM withdrawal group (n = 30) and slow-taper group (n = 27). In the acute-withdrawal group, all ASMs were discontinued once the patients were admitted. In the slow-taper group, the doses of ASMs were gradually reduced by 15-30% daily. We also evaluated the safety of the acute-withdrawal and slow-taper protocols. The mean lengths of hospital stay were 3.8 ± 1.92 and 5.2 ± 0.69 days in the acute-withdrawal and slow-taper groups, respectively (p |
| 24. |
Naoto Kuroda, Takafumi Kubota, Toru Horinouchi, Naoki Ikegaya, Yu Kitazawa, Satoshi Kodama, Teppei Matsubara, Naoto Nagino, Shuichiro Neshige, Temma Soga, Daichi Sone, Yutaro Takayama, Izumi Kuramochi, Kousuke Kanemoto, Akio Ikeda, Kiyohito Terada, Hiroko Goji, Shinji Ohara, Koichi Hagiwara, Takashi Kamada, Koji Iida, Nobutsune Ishikawa, Hideaki Shiraishi, Osato Iwata, Hidenori Sugano, Yasushi Iimura, Takuichiro Higashi, Hiroshi Hosoyama, Ryosuke Hanaya, Akihiro Shimotake, Takayuki Kikuchi, Takeshi Yoshida, Hiroshi Shigeto, Jun Yokoyama, Takahiko Mukaino, Masaaki Kato, Masanori Sekimoto, Masahiro Mizobuchi, Yoko Aburakawa, Masaki Iwasaki, Eiji Nakagawa, Tomohiro Iwata, Kentaro Tokumoto, Takuji Nishida, Yukitoshi Takahashi, Kenjiro Kikuchi, Ryuki Matsuura, Shin ichiro Hamano, Hideo Yamanouchi, Satsuki Watanabe, Ayataka Fujimoto, Hideo Enoki, Kyoichi Tomoto, Masako Watanabe, Youji Takubo, Toshihiko Fukuchi, Hidetoshi Nakamoto, Yuichi Kubota, Naoto Kunii, Yuichiro Shirota, Eiichi Ishikawa, Nobukazu Nakasato, Taketoshi Maehara, Motoki Inaji, Shunsuke Takagi, Takashi Enokizono, Yosuke Masuda, Takahiro Hayashi, Risk factors for psychological distress in electroencephalography technicians during the COVID-19 pandemic: A national-level cross-sectional survey in Japan, Epilepsy and Behavior, 10.1016/j.yebeh.2021.108361, 125, 2021.12, Objective: To identify the risk factors for psychological distress in electroencephalography (EEG) technicians during the coronavirus disease 2019 (COVID-19) pandemic. Method: In this national-level cross-sectional survey initiated by Japan Young Epilepsy Section (YES-Japan), a questionnaire was administered to 173 technicians engaged in EEG at four clinics specializing in epilepsy care and 20 hospitals accredited as (quasi-) epilepsy centers or epilepsy training facilities in Japan from March 1 to April 30, 2021. We collected data on participants’ profiles, information about work, and psychological distress outcome measurements, such as the K-6 and Tokyo Metropolitan Distress Scale for Pandemic (TMDP). Linear regression analysis was used to identify the risk factors for psychological distress. Factors that were significantly associated with psychological distress in the univariate analysis were subjected to multivariate analysis. Results: Among the 142 respondents (response rate: 82%), 128 were included in the final analysis. As many as 35.2% of EEG technicians have been under psychological distress. In multivariate linear regression analysis for K-6, female sex, examination for patients (suspected) with COVID-19, and change in salary or bonus were independent associated factors for psychological distress. Contrastingly, in multivariate linear regression analysis for TMDP, female sex, presence of cohabitants who had to be separated from the respondent due to this pandemic, and change in salary or bonus were independent associated factors for psychological distress. Conclusion: We successfully identified the risk factors associated with psychological distress in EEG technicians during the COVID-19 pandemic. Our results may help in understanding the psychological stress in EEG technicians during the COVID-19 pandemic and improving the work environment, which is necessary to maintain the mental health of EEG technicians.. |
| 25. |
迎伸孝, 下川能史, 森岡隆人, 酒田あゆみ, 渡邉恵利子, 上原平, 重藤寛史, 吉本幸司, 内側側頭葉のictal activityが頭皮上脳波にictal activityとして反映される条件について 頭蓋内外同時脳波記録症例による考察, 日本てんかん外科学会プログラム・抄録集, 10.1177/15500594211062702, 45th, 2, 15500594211062702-15500594211062702, 2021.11. |
| 26. |
Koichi Hagiwara, Toshiki Okadome, Takahiko Mukaino, Taira Uehara, Hideaki Tanaka, Takashi Kamada, Ayako Miyoshi, Naoki Akamatsu, Shinji Ohara, Hiroshi Shigeto, Ictal asystole as a manifestation of pure insular epilepsy., Seizure, 10.1016/j.seizure.2021.06.026, 91, 192-195, 2021.10. |
| 27. |
Teppei Matsubara, Seppo P Ahlfors, Tatsuya Mima, Koichi Hagiwara, Hiroshi Shigeto, Shozo Tobimatsu, Yoshinobu Goto, Steven Stufflebeam, Bilateral Representation of Sensorimotor Responses in Benign Adult Familial Myoclonus Epilepsy: An MEG Study., Frontiers in neurology, 10.3389/fneur.2021.759866, 12, 759866-759866, 2021.10, Patients with cortical reflex myoclonus manifest typical neurophysiologic characteristics due to primary sensorimotor cortex (S1/M1) hyperexcitability, namely, contralateral giant somatosensory-evoked potentials/fields and a C-reflex (CR) in the stimulated arm. Some patients show a CR in both arms in response to unilateral stimulation, with about 10-ms delay in the non-stimulated compared with the stimulated arm. This bilateral C-reflex (BCR) may reflect strong involvement of bilateral S1/M1. However, the significance and exact pathophysiology of BCR within 50 ms are yet to be established because it is difficult to identify a true ipsilateral response in the presence of the giant component in the contralateral hemisphere. We hypothesized that in patients with BCR, bilateral S1/M1 activity will be detected using MEG source localization and interhemispheric connectivity will be stronger than in healthy controls (HCs) between S1/M1 cortices. We recruited five patients with cortical reflex myoclonus with BCR and 15 HCs. All patients had benign adult familial myoclonus epilepsy. The median nerve was electrically stimulated unilaterally. Ipsilateral activity was investigated in functional regions of interest that were determined by the N20m response to contralateral stimulation. Functional connectivity was investigated using weighted phase-lag index (wPLI) in the time-frequency window of 30-50 ms and 30-100 Hz. Among seven of the 10 arms of the patients who showed BCR, the average onset-to-onset delay between the stimulated and the non-stimulated arm was 8.4 ms. Ipsilateral S1/M1 activity was prominent in patients. The average time difference between bilateral cortical activities was 9.4 ms. The average wPLI was significantly higher in the patients compared with HCs in specific cortico-cortical connections. These connections included precentral-precentral, postcentral-precentral, inferior parietal (IP)-precentral, and IP-postcentral cortices interhemispherically (contralateral region-ipsilateral region), and precentral-IP and postcentral-IP intrahemispherically (contralateral region-contralateral region). The ipsilateral response in patients with BCR may be a pathologically enhanced motor response homologous to the giant component, which was too weak to be reliably detected in HCs. Bilateral representation of sensorimotor responses is associated with disinhibition of the transcallosal inhibitory pathway within homologous motor cortices, which is mediated by the IP. IP may play a role in suppressing the inappropriate movements seen in cortical myoclonus.. |
| 28. |
Taira Uehara, Hiroshi Shigeto, Takahiko Mukaino, Jun Yokoyama, Toshiki Okadome, Ryo Yamasaki, Katsuya Ogata, Nobutaka Mukae, Ayumi Sakata, Shozo Tobimatsu, Jun-Ichi Kira, Rapidly spreading seizures arise from large-scale functional brain networks in focal epilepsy., NeuroImage, 10.1016/j.neuroimage.2021.118104, 237, 118104-118104, 2021.08, It remains unclear whether epileptogenic networks in focal epilepsy develop on physiological networks. This work aimed to explore the association between the rapid spread of ictal fast activity (IFA), a proposed biomarker for epileptogenic networks, and the functional connectivity or networks of healthy subjects. We reviewed 45 patients with focal epilepsy who underwent electrocorticographic (ECoG) recordings to identify the patients showing the rapid spread of IFA. IFA power was quantified as normalized beta-gamma band power. Using published resting-state functional magnetic resonance imaging databases, we estimated resting-state functional connectivity of healthy subjects (RSFC-HS) and resting-state networks of healthy subjects (RSNs-HS) at the locations corresponding to the patients' electrodes. We predicted the IFA power of each electrode based on RSFC-HS between electrode locations (RSFC-HS-based prediction) using a recently developed method, termed activity flow mapping. RSNs-HS were identified using seed-based and atlas-based methods. We compared IFA power with RSFC-HS-based prediction or RSNs-HS using non-parametric correlation coefficients. RSFC and seed-based RSNs of each patient (RSFC-PT and seed-based RSNs-PT) were also estimated using interictal ECoG data and compared with IFA power in the same way as RSFC-HS and seed-based RSNs-HS. Spatial autocorrelation-preserving randomization tests were performed for significance testing. Nine patients met the inclusion criteria. None of the patients had reflex seizures. Six patients showed pathological evidence of a structural etiology. In total, we analyzed 49 seizures (2-13 seizures per patient). We observed significant correlations between IFA power and RSFC-HS-based prediction, seed-based RSNs-HS, or atlas-based RSNs-HS in 28 (57.1%), 21 (42.9%), and 28 (57.1%) seizures, respectively. Thirty-two (65.3%) seizures showed a significant correlation with either seed-based or atlas-based RSNs-HS, but this ratio varied across patients: 27 (93.1%) of 29 seizures in six patients correlated with either of them. Among atlas-based RSNs-HS, correlated RSNs-HS with IFA power included the default mode, control, dorsal attention, somatomotor, and temporal-parietal networks. We could not obtain RSFC-PT and RSNs-PT in one patient due to frequent interictal epileptiform discharges. In the remaining eight patients, most of the seizures showed significant correlations between IFA power and RSFC-PT-based prediction or seed-based RSNs-PT. Our study provides evidence that the rapid spread of IFA in focal epilepsy can arise from physiological RSNs. This finding suggests an overlap between epileptogenic and functional networks, which may explain why functional networks in patients with focal epilepsy frequently disrupt.. |
| 29. |
Nobutaka Mukae, Daisuke Kuga, Daisuke Murakami, Noritaka Komune, Yusuke Miyamoto, Takafumi Shimogawa, Ayumi Sakata, Hiroshi Shigeto, Toru Iwaki, Takato Morioka, Masahiro Mizoguchi, Endonasal endoscopic surgery for temporal lobe epilepsy associated with sphenoidal encephalocele., Surgical neurology international, 10.25259/SNI_542_2021, 12, 379-379, 2021.07, Background: Temporal lobe epilepsy (TLE) associated with temporal lobe encephalocele is rare, and the precise epileptogenic mechanisms and surgical strategies for such cases are still unknown. Although the previous studies have reported good seizure outcomes following chronic subdural electrode recording through invasive craniotomy, only few studies have reported successful epilepsy surgery through endoscopic endonasal lesionectomy. Case Description: An 18-year-old man developed generalized convulsions at the age of 15 years. Despite treatment with optimal doses of antiepileptic drugs, episodes of speech and reading difficulties were observed 2-3 times per week. Long-term video electroencephalogram (EEG) revealed ictal activities starting from the left anterior temporal region. Magnetic resonance imaging revealed a temporal lobe encephalocele in the left lateral fossa of the sphenoidal sinus (sphenoidal encephalocele). Through the endoscopic endonasal approach, the tip of the encephalocele was exposed. A depth electrode was inserted into the encephalocele, which showed frequent spikes superimposed with high-frequency oscillations (HFOs) suggesting intrinsic epileptogenicity. The encephalocele was resected 8 mm from the tip. Twelve months postoperatively, the patient had no recurrence of seizures on tapering of the medication. Conclusion: TLE associated with sphenoidal encephalocele could be controlled with endoscopic endonasal lesionectomy, after confirming the high epileptogenicity with analysis of HFOs of intraoperative EEG recorded using an intralesional depth electrode.. |
| 30. |
下川 能史, 迎 伸孝, 森岡 隆人, 重藤 寛史, 酒田 あゆみ, 渡邉 恵利子, 溝口 昌弘, 下顎・オトガイ電極を用いた側頭葉内側部由来てんかん性放電の検出 頭蓋内外脳波同時記録による検証, てんかん研究, 39, 2, 410-410, 2021.07. |
| 31. |
迎 伸孝, 空閑 太亮, 村上 大輔, 小宗 徳孝, 下川 能史, 酒田 あゆみ, 重藤 寛史, 岩城 徹, 森岡 隆人, 溝口 昌弘, 蝶形骨洞側窩髄膜脳瘤に伴う側頭葉てんかんに対し経鼻内視鏡下切除を行った1症例, てんかん研究, 39, 2, 424-424, 2021.07. |
| 32. |
渡邉 恵利子, 酒田 あゆみ, 迎 伸孝, 森岡 隆人, 重藤 寛史, 上原 平, 堀田 多恵子, 康 東天, 頭蓋内外同時記録で見る14&6Hz陽性棘波, 日本医学検査学会抄録集, 70回, 298-298, 2021.05. |
| 33. |
Mitsunori Shimmura, Taira Uehara, Katsuya Ogata, Hiroshi Shigeto, Tomoko Maeda, Ayumi Sakata, Ryo Yamasaki, Jun ichi Kira, Corrigendum to “Higher postictal parasympathetic activity following greater ictal heart rate increase in right- than left-sided seizures” (Epilepsy & Behavior (2019) 97 (161–168), (S1525505019300174), (10.1016/j.yebeh.2019.05.026)), Epilepsy and Behavior, 10.1016/j.yebeh.2019.106865, 103, 2020.02, The authors regret that the legend of Fig. 4 in the above article contained errors. The sample sizes for right-sided seizures (n = 27) and left-sided seizures (n = 27) are wrong. The corrected sentence is as follows: Red lines indicate right-sided seizures (n = 24), and blue lines indicate left-sided seizures (n = 24). This is a simple typographical error and does not change the conclusions of the paper. The authors would like to apologize for any inconvenience caused.. |
| 34. |
Shimmura M, Uehara T, Ogata K, Shigeto H, Maeda T, Sakata A, Yamasaki R, Kira JI., Higher postictal parasympathetic activity following greater ictal heart rate increase in right- than left-sided seizures., Epilepsy Behav, 10.1016/j.yebeh.2019.05.026., 97, 161-168, 2019.08, 心拍から側頭葉てんかん性活動の側在性を推定できる。. |
| 35. |
Mitsunori Shimmura, Taira Uehara, Katsuya Ogata, Hiroshi Shigeto, Tomoko Maeda, Ayumi Sakata, Ryo Yamasaki, Jun-Ichi Kira, Higher postictal parasympathetic activity following greater ictal heart rate increase in right- than left-sided seizures., Epilepsy & behavior : E&B, 10.1016/j.yebeh.2019.05.026, 97, Pt A, 161-168, 2019.08, OBJECTIVES: The objectives of this study were to determine how hemispheric laterality of seizure activity influences periictal heart rate variability (HRV) and investigate the ability of HRV parameters to discriminate right- and left-sided seizures. METHODS: Long-term video electroencephalogram-electrocardiogram recordings of 54 focal seizures in 25 patients with focal epilepsy were reviewed. Using linear mixed models, we examined the effect of seizure laterality on linear (standard deviation of R-R intervals [SDNN], root mean square of successive differences [RMSSD], low frequency [LF] and high frequency [HF] power of HRV, and LF/HF) and nonlinear (standard deviation [SD]1, SD2, and SD2/SD1 derived from Poincaré plots) periictal HRV parameters, the magnitude of heart rate (HR) changes, and the onset time of increased HR. Receiver operating characteristics (ROC) were used to determine the ability of these parameters to discriminate between right- and left-sided seizures. RESULTS: Postictal SDNN, RMSSD, LF, HF, SD1, and SD2 were higher in right- than left-sided seizures. Root mean square of successive difference and HF were decreased after left- but not right-sided seizures. Standard deviation of R-R intervals, LF, and SD1 were increased after right- but not left-sided seizures. Increased ictal HR was earlier and larger in right- than left-sided seizures. Postictal HF showed the greatest area under the ROC curve (AUC) (0.87) for discriminating right- and left-sided seizures. CONCLUSIONS: Our data suggest that postictal parasympathetic activity is higher, whereas ictal HR increase is greater, in right- than left-sided seizures. Involvement of the right hemisphere may be associated with postictal autonomic instability. Postictal HRV parameters may provide useful information on hemispheric laterality of seizure activity.. |
| 36. |
Mitsunori Shimmura, Taira Uehara, Katsuya Ogata, Hiroshi Shigeto, Tomoko Maeda, Ayumi Sakata, Ryo Yamasaki, Jun-Ichi Kira, Higher postictal parasympathetic activity following greater ictal heart rate increase in right- than left-sided seizures., Epilepsy & behavior : E&B, 10.1016/j.yebeh.2019.05.026, 97, Pt A, 161-168, 2019.08, OBJECTIVES: The objectives of this study were to determine how hemispheric laterality of seizure activity influences periictal heart rate variability (HRV) and investigate the ability of HRV parameters to discriminate right- and left-sided seizures. METHODS: Long-term video electroencephalogram-electrocardiogram recordings of 54 focal seizures in 25 patients with focal epilepsy were reviewed. Using linear mixed models, we examined the effect of seizure laterality on linear (standard deviation of R-R intervals [SDNN], root mean square of successive differences [RMSSD], low frequency [LF] and high frequency [HF] power of HRV, and LF/HF) and nonlinear (standard deviation [SD]1, SD2, and SD2/SD1 derived from Poincaré plots) periictal HRV parameters, the magnitude of heart rate (HR) changes, and the onset time of increased HR. Receiver operating characteristics (ROC) were used to determine the ability of these parameters to discriminate between right- and left-sided seizures. RESULTS: Postictal SDNN, RMSSD, LF, HF, SD1, and SD2 were higher in right- than left-sided seizures. Root mean square of successive difference and HF were decreased after left- but not right-sided seizures. Standard deviation of R-R intervals, LF, and SD1 were increased after right- but not left-sided seizures. Increased ictal HR was earlier and larger in right- than left-sided seizures. Postictal HF showed the greatest area under the ROC curve (AUC) (0.87) for discriminating right- and left-sided seizures. CONCLUSIONS: Our data suggest that postictal parasympathetic activity is higher, whereas ictal HR increase is greater, in right- than left-sided seizures. Involvement of the right hemisphere may be associated with postictal autonomic instability. Postictal HRV parameters may provide useful information on hemispheric laterality of seizure activity.. |
| 37. |
Teppei Matsubara, Katsuya Ogata, Naruhito Hironaga, Taira Uehara, Takako Mitsudo, Hiroshi Shigeto, Toshihiko Maekawa, Shozo Tobimatsu, Monaural 40-Hz auditory steady-state magnetic responses can be useful for identifying epileptic focus in mesial temporal lobe epilepsy., Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 10.1016/j.clinph.2018.11.026, 130, 3, 341-351, 2019.03, © 2018 International Federation of Clinical Neurophysiology Objective: Patients with mesial temporal lobe epilepsy (mTLE) often exhibit central auditory processing (CAP) dysfunction. Monaural 40-Hz auditory steady-state magnetic responses (ASSRs) were recorded to explore the pathophysiology of mTLE. Methods: Eighteen left mTLE patients, 11 right mTLE patients and 16 healthy controls (HCs) were examined. Monaural clicks were presented at a rate of 40 Hz. Phase-locking factor (PLF) and power values were analyzed within bilateral Heschl's gyri. Results: Monaural 40-Hz ASSR demonstrated temporal frequency dynamics in both PLF and power data. Symmetrical hemispheric contralaterality was revealed in HCs. However, predominant contralaterality was absent in mTLE patients. Specifically, right mTLE patients exhibited a lack of contralaterality in response to left ear but not right ear stimulation, and vice versa in left mTLE patients. Conclusion: This is the first study to use monaural 40-Hz ASSR with unilateral mTLE patients to clarify the relationship between CAP and epileptic focus. CAP dysfunction was characterized by a lack of contralaterality corresponding to epileptic focus. Significance: Monaural 40-Hz ASSR can provide useful information for localizing epileptic focus in mTLE patients.. |
| 38. |
板倉朋子, 酒田あゆみ, 渡邉恵利子, 前田トモ子, 上原平, 重藤寛史, 堀田多恵子, KANG Dongchon, KANG Dongchon, 判読結果比較機能を用いた脳波技師の施設内スキルコントロールの試み, 日本臨床検査自動化学会会誌, 44, 1, 34-40, 2019.01, 1997年より脳神経検査システムを導入し、オーダー連携による脳波検査、結果報告、管理を一元的に行っている。従来のレポート作成では技師による下書き、記載者および記載内容の履歴について表示されていなかった。一つのレポートに複数の技師が関与するにも関わらず、誰がどの所見を記載したのか詳細が不明であった。そこで、誰がどの所見を記載したのか履歴が残るレポート比較機能を構築し、導入した。医師にも判読研修中の医師と臨床評価だけでなく判読教育可能な医師がいるため、判読研修中医師は、中堅以上の技師の所見を参考にして入力する手立てとしても利用でき、判読教育可能な医師はそれぞれの技師や判読研修中医師の習熟度が把握できた。構築したレポート比較機能を使用し、日常的に脳波所見の目合わせを行っており、脳波検査における内部精度管理の一助としている。これに加え、外部精度管理の一環として他施設との医師主導型脳波カンファレンスに参加し、脳波判読の目合わせを行っている。それぞれの技師がどの程度脳波所見を認識しながら記録しているのか習熟度を把握でき、教育にも反映しやすくなった。. |
| 39. |
Teppei Matsubara, Katsuya Ogata, Naruhito Hironaga, Yoshikazu Kikuchi, Taira Uehara, Hiroshi Chatani, Takako Mitsudo, Hiroshi Shigeto, Shozo Tobimatsu, Altered neural synchronization to pure tone stimulation in patients with mesial temporal lobe epilepsy: An MEG study., Epilepsy & behavior : E&B, 10.1016/j.yebeh.2018.08.036, 88, 96-105, 2018.11, OBJECTIVE: Our previous study of monaural auditory evoked magnetic fields (AEFs) demonstrated that hippocampal sclerosis significantly modulated auditory processing in patients with mesial temporal lobe epilepsy (mTLE). However, the small sample size (n = 17) and focus on the M100 response were insufficient to elucidate the lateralization of the epileptic focus. Therefore, we increased the number of patients with mTLE (n = 39) to examine whether neural synchronization induced by monaural pure tone stimulation provides useful diagnostic information about epileptic foci in patients with unilateral mTLE. METHODS: Twenty-five patients with left mTLE, 14 patients with right mTLE, and 32 healthy controls (HCs) were recruited. Auditory stimuli of 500-Hz tone burst were monaurally presented to subjects. The AEF data were analyzed with source estimation of M100 responses in bilateral auditory cortices (ACs). Neural synchronization within ACs and between ACs was evaluated with phase-locking factor (PLF) and phase-locking value (PLV), respectively. Linear discriminant analysis was performed for diagnosis and lateralization of epileptic focus. RESULTS: The M100 amplitude revealed that patients with right mTLE exhibited smaller M100 amplitude than patients with left mTLE and HCs. Interestingly, PLF was able to differentiate the groups with mTLE, with decreased PLFs in the alpha band observed in patients with right mTLE compared with those (PLFs) in patients with left mTLE. Right hemispheric predominance was confirmed in both HCs and patients with left mTLE while patients with right mTLE showed a lack of right hemispheric predominance. Functional connectivity between bilateral ACs (PLV) was reduced in both patients with right and left mTLE compared with that of HCs. The accuracy of diagnosis and lateralization was 80%-90%. CONCLUSION: Auditory cortex subnormal function was more pronounced in patients with right mTLE compared with that in patients with left mTLE as well as HCs. Monaural AEFs can be used to reveal the pathophysiology of mTLE. Overall, our results indicate that altered neural synchronization may provide useful information about possible functional deterioration in patients with unilateral mTLE.. |
| 40. |
茶谷裕, 重藤寛史, 赤松直樹, 大原信司, 言語野を含まない左前頭葉切除後に一過性の超皮質性運動性失語を呈した難治性てんかんの1例, 日本てんかん外科学会プログラム・抄録集, 40th, 2017.11. |
| 41. |
Mitsunori Shimmura, Taira Uehara, Kenichiro Yamashita, Hiroshi Shigeto, Ryo Yamasaki, Kinya Ishikawa, Jun-Ichi Kira, Slowed abduction during smooth pursuit eye movement in episodic ataxia type 2 with a novel CACNA1A mutation., Journal of the neurological sciences, 10.1016/j.jns.2017.07.040, 381, 4-6, 2017.10. |
| 42. |
Jun Yokoyama, Hiroo Yamaguchi, Hiroshi Shigeto, Takeshi Uchiumi, Hiroyuki Murai, Jun-Ichi Kira, A case of rhabdomyolysis after status epilepticus without stroke-like episodes in mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes., Rinsho shinkeigaku = Clinical neurology, 10.5692/clinicalneurol.cn-001044, 57, 7, 400-401, 2017.07. |
| 43. |
Takashi Irie, Hiroshi Shigeto, Junpei Koge, Hiroo Yamaguchi, Hiroyuki Murai, Jun Ichi Kira, Dermatomyositis complicated with asymmetric peripheral neuritis on exacerbation: A case report and literature review, Clinical and Experimental Neuroimmunology, 10.1111/cen3.12332, 7, 4, 373-380, 2016.11, We describe a 69-year-old woman with dermatomyositis who presented with asymmetric peripheral neuritis. The patient first developed dermatomyositis at 39 years-of-age
her symptoms improved several years later with oral prednisolone treatment. A year and a half before admission to our hospital, she developed a sensory disturbance in her feet that gradually expanded to both legs with left dominance. Six months later, bilateral leg muscle weakness and proximal muscle tenderness appeared. Neurological examination at admission revealed proximal muscle weakness and atrophy of all four limbs. Ankle jerk was absent bilaterally. There was sensory impairment in the left hand and both lower limbs, with more severe involvement of the left side and the medial side. Electrophysiological tests showed decreased sensory nerve action potentials in the left superficial fibular nerve and bilateral sural nerves, and decreased motor action potentials in the bilateral fibular nerves. We diagnosed mononeuritis multiplex as a complication of dermatomyositis. Her symptoms of mononeuritis multiplex and dermatomyositis were successfully treated with intravenous methylprednisolone pulse therapy followed by oral prednisolone therapy. Although our literature search found nine cases of dermatomyositis with polyneuropathy/polyradiculoneuropathy, most of which involved axonal neuropathy, this is the first case report of dermatomyositis presenting with mononeuritis multiplex.. |
| 44. |
Yuki Matsushita, Yasunari Sakai, Mitsunori Shimmura, Hiroshi Shigeto, Miki Nishio, Satoshi Akamine, Masafumi Sanefuji, Yoshito Ishizaki, Hiroyuki Torisu, Yusaku Nakabeppu, Akira Suzuki, Hidetoshi Takada, Toshiro Hara, Corrigendum: Hyperactive mTOR signals in the proopiomelanocortin-expressing hippocampal neurons cause age-dependent epilepsy and premature death in mice., Scientific reports, 10.1038/srep27164, 6, 27164-27164, 2016.06, Epilepsy is a frequent comorbidity in patients with focal cortical dysplasia (FCD). Recent studies utilizing massive sequencing data identified subsets of genes that are associated with epilepsy and FCD. AKT and mTOR-related signals have been recently implicated in the pathogenic processes of epilepsy and FCD. To clarify the functional roles of the AKT-mTOR pathway in the hippocampal neurons, we generated conditional knockout mice harboring the deletion of Pten (Pten-cKO) in Proopiomelanocortin-expressing neurons. The Pten-cKO mice developed normally until 8 weeks of age, then presented generalized seizures at 8-10 weeks of age. Video-monitored electroencephalograms detected paroxysmal discharges emerging from the cerebral cortex and hippocampus. These mice showed progressive hypertrophy of the dentate gyrus (DG) with increased expressions of excitatory synaptic markers (Psd95, Shank3 and Homer). In contrast, the expression of inhibitory neurons (Gad67) was decreased at 6-8 weeks of age. Immunofluorescence studies revealed the abnormal sprouting of mossy fibers in the DG of the Pten-cKO mice prior to the onset of seizures. The treatment of these mice with an mTOR inhibitor rapamycin successfully prevented the development of seizures and reversed these molecular phenotypes. These data indicate that the mTOR pathway regulates hippocampal excitability in the postnatal brain.. |
| 45. |
水野 裕理, 重藤 寛史, 山田 猛, 前田 教寿, 鈴木 諭, 吉良 潤一, 2回目の脳生検により原発性中枢神経系血管炎の確定診断に至り治療しえた1例, 臨床神経学, 10.5692/clinicalneurol.cn-000847, 56, 3, 186-90, 2016.06, 症例は53歳男性．左方注視時複視で発症し，頭部MRIで造影効果のある多発脳病変を認めた．悪性リンパ腫が疑われ前医で脳生検を行ったが悪性所見はなく，血管周囲にリンパ球の集簇を認めることから免疫関連性脳炎が疑われ，ステロイドパルス，シクロホスファミド投与，血漿交換等の免疫療法を行うも治療に反応しなかった．当院に転院後，脳生検を再度行い，最終的に原発性中枢神経系血管炎と診断した．ステロイドパルスとメトトレキサートの投与を行い病巣は縮小した．一度の脳生検では正確な病理診断がつかず，その後も侵襲的な治療が必要な場合は，複数回脳生検を行い正確な診断に至る必要がある．. |
| 46. |
横山 淳, 山口 浩雄, 重藤 寛史, 内海 健, 村井 弘之, 吉良 潤一, Stroke-like episodesを呈さずに痙攣重積と横紋筋融解症で発症したmitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes（MELAS）の1例, 臨床神経学, 10.5692/clinicalneurol.cn-000834, 56, 3, 204-7, 2016.06, 症例は24歳の男性．夜間飲酒した翌朝に痙攣を認め当院救急部に搬送された．到着後に痙攣重積を呈して人工呼吸器管理となった．脳幹反射の異常や病的反射，髄膜刺激徴候は認めなかった．頭部MRIの拡散強調画像で異常信号はなく，左後頭葉に陳旧性梗塞様の所見を認めた．入院直後より横紋筋融解症による高CK血症と急性腎不全を呈し持続血液透析濾過法を開始した．髄液中L/P比の著明な増加よりミトコンドリア病を疑い，末梢血にてミトコンドリアDNAのA3243G変異（ヘテロプラスミー20％）が判明しmitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes（MELAS）と診断した．本症例はMELASとしては非典型的な経過を辿ったため貴重な症例と考えられた．. |
| 47. |
進村 光規, 河村 信利, 立石 貴久, 重藤 寛史, 村井 弘之, 吉良 潤一, 塩酸クロニジンが有効であった急性散在性脳脊髄炎および低酸素脳症後のparoxysmal sympathetic stormの1例, 臨床神経学, 10.5692/clinicalneurol.cn-000793, 56, 2, 108-11, 2016.06, 症例は17歳女性．急性散在性脳脊髄炎を発症後に重度の誤嚥性肺炎を合併，その際に数分間の呼吸停止があり，頭部MRI検査で低酸素脳症の所見を認めた．その後，突発的な高体温，高血圧，頻脈，過呼吸，筋緊張異常を呈する，交感神経の過剰興奮と思われる発作を繰り返すようになった．発作時の採血検査にてカテコラミンが上昇しており，低酸素脳症に伴うparoxysmal sympathetic stormと診断．塩酸クロニジンの内服で発作は明らかに減少した．. |
| 48. |
Yuki Matsushita, Yasunari Sakai, Mitsunori Shimmura, Hiroshi Shigeto, Miki Nishio, Satoshi Akamine, Masafumi Sanefuji, Yoshito Ishizaki, Hiroyuki Torisu, Yusaku Nakabeppu, Akira Suzuki, Hidetoshi Takada, Toshiro Hara, Hyperactive mTOR signals in the proopiomelanocortin-expressing hippocampal neurons cause age-dependent epilepsy and premature death in mice., Scientific reports, 10.1038/srep22991, 6, 22991-22991, 2016.03, Epilepsy is a frequent comorbidity in patients with focal cortical dysplasia (FCD). Recent studies utilizing massive sequencing data identified subsets of genes that are associated with epilepsy and FCD. AKT and mTOR-related signals have been recently implicated in the pathogenic processes of epilepsy and FCD. To clarify the functional roles of the AKT-mTOR pathway in the hippocampal neurons, we generated conditional knockout mice harboring the deletion of Pten (Pten-cKO) in Proopiomelanocortin-expressing neurons. The Pten-cKO mice developed normally until 8 weeks of age, then presented generalized seizures at 8-10 weeks of age. Video-monitored electroencephalograms detected paroxysmal discharges emerging from the cerebral cortex and hippocampus. These mice showed progressive hypertrophy of the dentate gyrus (DG) with increased expressions of excitatory synaptic markers (Psd95, Shank3 and Homer). In contrast, the expression of inhibitory neurons (Gad67) was decreased at 6-8 weeks of age. Immunofluorescence studies revealed the abnormal sprouting of mossy fibers in the DG of the Pten-cKO mice prior to the onset of seizures. The treatment of these mice with an mTOR inhibitor rapamycin successfully prevented the development of seizures and reversed these molecular phenotypes. These data indicate that the mTOR pathway regulates hippocampal excitability in the postnatal brain.. |
| 49. |
Hiroshi Chatani, Koichi Hagiwara, Naruhito Hironaga, Katsuya Ogata, Hiroshi Shigeto, Takato Morioka, Ayumi Sakata, Kimiaki Hashiguchi, Nobuya Murakami, Taira Uehara, Jun-ichi Kira, Shozo Tobimatsu, Neuromagnetic evidence for hippocampal modulation of auditory processing, NEUROIMAGE, 10.1016/j.neuroimage.2015.09.006, 124, Pt A, 256-266, 2016.01, The hippocampus is well known to be involved in memory, as well as in perceptual processing. To date, the electrophysiological process by which unilateral hippocampal lesions, such as hippocampal sclerosis (HS), modulate the auditory processing remains unknown. Auditory-evoked magnetic fields (AEFs) are valuable for evaluating auditory functions, because M100, a major component of AEFs, originates from auditory areas. Therefore, AEFs of mesial temporal lobe epilepsy (mTLE, n = 17) with unilateral HS were compared with those of healthy (HC, n= 17) and disease controls (n= 9), thereby determining whether AEFs were indicative of hippocampal influences on the auditory processing. Monaural tone-burst stimuli were presented for each side, followed by analysis of M100 and a previously less characterized exogenous component (M400: 300-500 ms). The frequency of acceptable M100 dipoles was significantly decreased in the HS side. Beam-forming-based source localization analysis also showed decreased activity of the auditory area, which corresponded to the inadequately estimated dipoles. M400 was found to be related to the medial temporal structure on the HS side. Volumetric analysis was also performed, focusing on the auditory-related areas (planum temporale, Heschl's gyrus, and superior temporal gyrus), as well as the hippocampus. M100 amplitudes positively correlated with hippocampal and planum temporale volumes in the HC group, whereas they negatively correlated with Heschl's gyrus volume in the mTLE group. Interestingly, significantly enhanced M400 component was observed in the HS side of the mTLE patients. In addition, the M400 component positively correlated with Heschl's gyrus volume and tended to positively correlate with disease duration. M400 was markedly diminished after hippocampal resection. Although volumetric analysis showed decreased hippocampal volume in the HS side, the planum temporale and Heschl's gyrus, the two major sources of M100, were preserved. These results suggested that HS significantly influenced AEFs. Therefore, we concluded that the hippocampus modulates auditory processing differently under normal conditions and in HS. (C) 2015 The Authors. Published by Elsevier Inc.. |
| 50. |
上原 平, 山口 浩雄, 重藤 寛史, Multimodal diagnostic approach for limbic encephalitis associated with anti-voltage-gated potassium channel complex antibodies, CLINICAL AND EXPERIMENTAL NEUROIMMUNOLOGY, 6, 2015.11. |
| 51. |
迫田礼子, 米川智, 上原平, 重藤寛史, 村井弘之, 前田教寿, 岩城徹, 吉良潤一, Radiation-induced myopathyによる首下がりを呈し,筋生検でネマリン小体を認めた1例, 臨床神経学(Web), 55, 2, 2015.11. |
| 52. |
水野裕理, 吉村基, 米川智, 重藤寛史, 山口浩雄, 山田猛, 前田教寿, 岩城徹, 村井弘之, 吉良潤一, 原発性中枢神経限局性血管炎の2例比較検討, 臨床神経学(Web), 55, 5, 2015.11. |
| 53. |
鳥山敬祐, 山口浩雄, 林信太郎, 松瀬大, 重藤寛史, 浅野喬, 田部勝也, 谷澤幸生, 村井弘之, 吉良潤一, 多彩な自律神経症状を呈したWolfram症候群の一例, 臨床神経学(Web), 55, 10, 2015.11. |
| 54. |
大原信司, 鎌田崇嗣, 重藤寛史, 赤松直樹, 谷脇予志秀, 松島俊夫, 巨大なくも膜嚢胞を認めた側頭葉てんかんの一手術例, 日本てんかん外科学会プログラム・抄録集, 39th, 2015.11. |
| 55. |
鎌田崇嗣, 重藤寛史, 赤松直樹, 谷脇予志秀, 大原信司, 松島俊夫, 巨大なくも膜嚢胞を認めた側頭葉てんかんの一例, 臨床神経学(Web), 55, 10, 2015.11. |
| 56. |
橋口公章, 森岡隆人, 迎伸孝, 村上信哉, 酒田あゆみ, 重藤寛史, 飯原弘二, 新皮質てんかんに対する術前計画としての頭皮上脳波と脳磁図の限界, 日本てんかん外科学会プログラム・抄録集, 38th, 2015.11. |
| 57. |
水野裕理, 米川智, 重藤寛史, 入江恵美子, 前田教寿, 吉良潤一, 頸椎症や転換性障害と診断され,後に先天性筋線維タイプ不均等症と判明した一例, 臨床神経学(Web), 55, 2, 2015.11. |
| 58. |
重藤寛史, 林信太郎, 吉良潤一, 食品を介したダイオキシン類等の人体への影響の把握とその治療法の開発等に関する研究 大脳認知機能の客観的評価法の開発および感覚系ニューロン関連蛋白発現変化の検討, 食品を介したダイオキシン類等の人体への影響の把握とその治療法の開発等に関する研究 平成24-26年度 総合研究報告書 平成26年度 総括・分担研究報告書, 2015.11. |
| 59. |
石橋 秀昭, 重藤 寛史, 鬼塚 俊明, Down症候群に合併した遅発性ミオクロニーてんかんの一例, てんかん研究, 10.3805/jjes.32.564, 32, 3, 564-567, 2015.10, 当院外来で45歳のてんかんを有するDown症候群の女性患者を経過観察している。42歳時、ミオクロニー発作を初発後、徐々に発作が増加し脱力・意識減損発作を伴うようになった。同時に覚醒度および反応性の低下が急速に進行した。他院でバルプロ酸、カルバマゼピンの処方を受けたが発作・覚醒度の低下は改善せず、当科を受診した。カルバマゼピンを中止し、バルプロ酸単剤で経過観察を行ったが著明な変化が見られず、レベチラセタム、ラモトリギンを追加処方した。1日に4～5回あった発作は完全に消失し活動性が向上したが、経過中認知障害の改善はみられなかった。Down症候群は医療の進歩に伴い、長期生存例が飛躍的に増加した。Down症候群と認知障害の合併は以前から知られているが、40歳以上の長期生存例では遅発性てんかんの合併が認知障害の合併より多いことが最近明らかとなってきた。本邦でもDown症患者の長期生存例がようやくその年代に達してきたので、このような症例に遭遇する機会が増加すると考えられる。. |
| 60. |
Chikara Yamashita, Hiroshi Shigeto, Norihisa Maeda, Takako Torii, Yasumasa Ohyagi, Jun Ichi Kira, A case of central pontine myelinolysis caused by hypophosphatemia secondary to refeeding syndrome, Case Reports in Neurology, 10.1159/000440711, 7, 3, 196-203, 2015.06, Central pontine myelinolysis (CPM), which was originally considered to be the result of rapid correction of chronic hyponatremia, is not necessarily accompanied by hyponatremia or drastic changes in serum sodium level. Here, we report a case of an anorexic 55-year-old male with a history of pharyngo-laryngo-esophagogastrectomy, initially hospitalized with status epilepticus. Although his consciousness gradually recovered as we were controlling his convulsion, it deteriorated again with new onset of anisocoria, and magnetic resonance imaging (MRI) at this point revealed CPM. Rapid change of serum sodium or osmolarity, which is often associated with CPM, had not been apparent throughout his hospitalization. Instead, a review of the serum biochemistry test results showed that serum phosphate had drastically declined the day before the MRI first detected CPM. In this case, we suspect that hypophosphatemia induced by refeeding syndrome greatly contributed to the occurrence of CPM.. |
| 61. |
村上 信哉, 森岡 隆人, 橋口 公章, 鈴木 諭, 重藤 寛史, 酒田 あゆみ, 佐々木 富男, 原著 胚芽異形成性上皮腫瘍に伴う難治性てんかん症例における発作起始域の臨床的･病理学的検討, BRAIN and NERVE, 10.11477/mf.1416200170, 67, 4, 525-32, 2015.04, 胚芽異形成性上皮腫瘍(DNT)のてんかん原性はいまだに議論の多いところであるが,DNTのてんかん原性は病理学的に合併する皮質形成異常に存在するという考え方が主流である。九州大学脳神経外科で行ったてんかん原性域としてDNTがみられた難治性てんかんの手術3例のうち,2例は慢性硬膜下電極記録を経由して手術を行い,1例は術中皮質電位記録を用いて手術を行った。慢性硬膜下電極記録を用いた2例とも,DNTの周囲皮質に発作起始域を同定し,これらを含めて切除し,良好な発作転帰を得た。しかし,同部位の病理学的検索では,軽度のグリオーシスがみられるのみで,皮質形成異常は合併していなかった。術中皮質電位記録を用いた側頭葉外側部DNTの1例では,側頭葉内側部に脳波異常域を同定したが,腫瘍を含めた側頭葉外側部を切除し,良好な発作転帰は得られなかった。DNT症例のてんかん外科における摘出範囲は,腫瘍の摘出だけでよいという考え方と,周囲皮質を含めて追加切除したほうがよいという考え方があるが,本報告のようにDNTのてんかん原性は症例によりさまざまであると考えられるので,慢性硬膜下電極記録を中心とした詳細な術前検査により正確なてんかん原性域の同定が重要である。(著者抄録). |
| 62. |
Nobutaka Mukae, Satoshi O Suzuki, Takato Morioka, Nobuya Murakami, Kimiaki Hashiguchi, Hiroshi Shigeto, Ayumi Sakata, Koji Iihara, ILAE focal cortical dysplasia type IIIc in the ictal onset zone in epileptic patients with solitary meningioangiomatosis., Epileptic disorders : international epilepsy journal with videotape, 10.1684/epd.2014.0695, 16, 4, 533-9, 2014.12, "Solitary" meningioangiomatosis (MA) is a rare, benign, hamartomatous lesion of the cerebral cortex and frequently leads to epilepsy. However, the source of the epileptogenicity in meningioangiomatosis remains controversial. We report two surgically-treated meningioangiomatosis cases with medically intractable epilepsy. In both cases, chronic subdural electrocorticogram (ECoG) recordings identified the ictal onset zone on apparently normal cortex, adjacent to and/or above the meningioangiomatosis lesion, not on the meningioangiomatosis lesion itself. The ictal onset zone was resected, along with the MA lesion, and good seizure outcome was achieved. Histological examination of the ictal onset zone revealed the presence of ILAE focal cortical dysplasia (FCD) type IIIc. Our case studies suggest that in the surgical management of epilepsy with meningioangiomatosis, it is important to identify undetected, but epileptogenic, ILAE FCD Type IIIc, using preoperative multimodal examinations, including chronic ECoG recordings.. |
| 63. |
森岡 隆人, 下川 能史, 佐山 徹郎, 橋口 公章, 村上 信哉, 重藤 寬史, 鈴木 諭, 酒田 あゆみ, 槇原 康亮, 飯原 弘二, 症例 迷走神経刺激療法目的で紹介され開頭手術治療を行った難治性てんかん患者, Neurological Surgery 脳神経外科, 10.11477/mf.1436200049, 42, 12, 1137-46, 2014.12, 迷走神経刺激療法(VNS)目的で紹介されたが、詳細な術前検査より開頭手術の適応と判断した難治性てんかん患者3例について報告した。3症例は発作間欠期脳波と画像所見の解離や、てんかん原性病変が多発性あるいは広範であることからVNSの対象として紹介されたが、頭皮上脳波、画像検査、核医学検査などの術前検査からそれぞれ左扁桃体腫大を伴う左内側側頭葉てんかん(TLE)、左下角前方の上衣下結節が関連したTLE、左前頭葉てんかんと診断し、開頭手術を行った結果、いずれも良好な発作転帰が得られた。今回の術前検査の中で特に開頭手術適応の決め手となったものは発作時脳波所見であり、VNSの術前検査でも必要であれば長時間ビデオ脳波検査を行うべきであると思われた。. |
| 64. |
宇根 隼人, 上原 平, 立石 貴久, 重藤 寛史, 大八木 保政, 吉良 潤一, B型インフルエンザ罹患後に非痙攣性てんかん重積状態をきたした1例, 臨床神経学, 10.5692/clinicalneurol.54.227, 54, 3, 227-230, 2014.11, 症例は24歳女性である．B型インフルエンザ罹患後，第9病日に意識障害をきたした．痙攣はみとめなかったが，脳波にててんかん性放電が持続しており，非痙攣性てんかん重積状態（non-convulsive status epilepticus; NCSE）と診断した．インフルエンザ脳症をうたがいステロイドパルス療法をおこない，その後プレドニゾロンの経口投与をおこなった．NCSEに対しては抗てんかん薬の投与をおこない，意識状態および脳波所見の改善をみとめた．NCSEの原因として，インフルエンザ脳症，あるいは元々てんかんの素因がありインフルエンザ感染によって惹起された病態が考えられた．. |
| 65. |
重藤寛史, てんかん II.てんかんの診断 脳波検査, 日本臨床, 72, 5, 2014.11. |
| 66. |
上原 平, 重藤 寛史, 吉良 潤一, てんかんと脳機能的ネットワークの関連, 臨床神経学, 10.5692/clinicalneurol.54.1139, 54, 12, 1139-41, 2014.11, 近年の安静状態機能的MRI研究によって，6～8個の大規模機能的ネットワークが，脳ネットワークの基本的構成要素であることが明らかになった．4例の難治性てんかん患者のECoG記録を解析し，発作起始時速波をみとめる複数の領域と，これら大規模機能的ネットワークの空間的分布を比較したところ，良く合致していた．大規模機能的ネットワークが，てんかん性活動の伝播に寄与することが示唆された．一方，てんかん患者で，発作間欠期に大規模機能的ネットワークの結合性が低下することが報告されている．てんかん性放電の伝播により機能的結合性が障害されている可能性が示唆され，今後の検討が必要である．. |
| 67. |
上原平, 重藤寛史, 吉良潤一, てんかんと脳機能的ネットワークの関連, 臨床神経学(Web), 54, 12, 2014.11. |
| 68. |
重藤寛史, ビデオで見るてんかん発作, 日本神経学会学術大会プログラム・抄録集, 55th, 2014.11. |
| 69. |
村上信哉, 森岡隆人, 迎伸孝, 橋口公章, 重藤寛史, 飯原弘二, 切除外科術後の発作残存に対して追加投与したレベチラセタムの効果, 日本てんかん外科学会プログラム・抄録集, 37th, 2014.11. |
| 70. |
Koichi Hagiwara, Hiroshi Shigeto, Age-related changes across the primary and secondary somatosensory areas: an analysis of neuromagnetic oscillatory activities, Clin Neurophysiol, 2014.05. |
| 71. |
Hiroshi Shigeto, Electroencephalography for patient with epilepsy, Nihon Rinsho, 2014.05. |
| 72. |
Koichi Hagiwara, Katsuya Ogata, Tsuyoshi Okamoto, Taira Uehara, Naruhito Hironaga, Hiroshi Shigeto, Jun-ichi Kira, Shozo Tobimatsu, Age-related changes across the primary and secondary somatosensory areas: An analysis of neuromagnetic oscillatory activities, CLINICAL NEUROPHYSIOLOGY, 10.1016/j.clinph.2013.10.005, 125, 5, 1021-1029, 2014.05, Objective: Age-related changes are well documented in the primary somatosensory cortex (SI). Based on previous somatosensory evoked potential studies, the amplitude of N20 typically increases with age probably due to cortical disinhibition. However, less is known about age-related change in the secondary somatosensory cortex (SII). The current study quantified age-related changes across SI and SII mainly based on oscillatory activity indices measured with magnetoencephalography.
Methods: We recorded somatosensory evoked magnetic fields (SEFs) to right median nerve stimulation in healthy young and old subjects and assessed major SEF components. Then, we evaluated the phase-locking factor (PLF) for local field synchrony on neural oscillations and the weighted phase-lag index (wPLI) for cortico-cortical synchrony between SI and SII.
Results: PLF was significantly increased in SI along with the increased amplitude of N20m in the old subjects. PLF was also increased in SII associated with a shortened peak latency of SEFs. wPLI analysis revealed the increased coherent activity between SI and SII.
Conclusions: Our results suggest that the functional coupling between SI and SII is influenced by the cortical disinhibition due to normal aging. Significance: We provide the first electrophysiological evidence for age-related changes in oscillatory neural activities across the somatosensory areas. (C) 2013 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.. |
| 73. |
Hiroshi Shigeto, [Electroencephalography for patient with epilepsy]., Nihon rinsho. Japanese journal of clinical medicine, 72, 5, 809-17, 2014.05, Electroencephalography (EEG) is the primary means by which epileptic activity in the brain is measured. The frequency of epileptic discharges is influenced by vigilance and biological rhythms. When checking for epileptic activity using EEG, measurements must be repeated and recordings made during sleep are recommended if epileptic discharges do not readily appear. Epileptic discharges must be classified as generalized or focal discharges, and discriminated from non-epileptic discharges such as vertex sharp transients, positive occipital sharp transients, 14 & 6 positive spike discharge, and artifacts. Attention should be paid to small sharp spikes, 6Hz spike and slow wave, focal slow waves, and generalized rhythmic slow waves, which should all be considered variants of epileptic activity. EEG provides information regarding focal and generalized brain dysfunction in addition to epileptic activity. Because the misreading of EEG may negatively affect the lives of patients, reading the EEG correctly is quite important.. |
| 74. |
Hideaki Miyaji, Naruhito Hironaga, Toshiro Umezaki, Koichi Hagiwara, Hiroshi Shigeto, Motohiro Sawatsubashi, Shozo Tobimatsu, Shizuo Komune, Neuromagnetic detection of the laryngeal area: Sensory-evoked fields to air-puff stimulation, NEUROIMAGE, 10.1016/j.neuroimage.2013.11.008, 88, 162-169, 2014.03, The sensory projections from the oral cavity, pharynx, and larynx are crucial in assuring safe deglutition, coughing, breathing, and voice production/speaking. Although several studies using neuroimaging techniques have demonstrated cortical activation related to pharyngeal and laryngeal functions, little is known regarding sensory projections from the laryngeal area to the somatosensory cortex. The purpose of this study was to establish the cortical activity evoked by somatic air-puff stimulation at the laryngeal mucosa using magnetoencephalography. Twelve healthy volunteers were trained to inhibit swallowing in response to air stimuli delivered to the larynx. Minimum norm estimates was performed on the laryngeal somatosensory evoked fields (LSEFs) to best differentiate the target activations from non-task-related activations. Evoked magnetic fields were recorded with acceptable reproducibility in the left hemisphere, with a peak latency of approximately 100 ms in 10 subjects. Peak activation was estimated at the caudolateral region of the primary somatosensory area (S1). These results establish the ability to detect LSEFs with an acceptable reproducibility within a single subject and among subjects. These results also suggest the existence of laryngeal somatic afferent input to the caudolateral region of S1 in human. Our findings indicate that further investigation in this area is needed, and should focus on laryngeal lateralization, swallowing, and speech processing. (C) 2013 Elsevier Inc All rights reserved.. |
| 75. |
Chikara Yamashita, Hiroshi Shigeto, Transient interhemispheric disconnection in a case of insulinoma-induced hypoglycemic encephalopathy, J Neurol Sci, 2013.12. |
| 76. |
Chikara Yamashita, Hiroshi Shigeto, Norihisa Maeda, Minako Kawaguchi, Mitsue Uryu, Satoru Motomura, Jun-ichi Kira, Transient interhemispheric disconnection in a case of insulinoma-induced hypoglycemic encephalopathy., Journal of the neurological sciences, 10.1016/j.jns.2013.09.025, 335, 1-2, 233-7, 2013.12, We report a case of a 22-year-old male who was transferred to our hospital in a comatose state following successive seizures. Low blood glucose had been detected upon his arrival at the previous hospital. He became responsive 12 days after the onset of coma. Upon regaining consciousness he exhibited severe dysarthria and several interhemispheric disconnection signs such as intermanual conflict, left-hand dysgraphia, left hemispatial neglect confined to the right hand, impaired interhemispheric transfer, and unilateral constructional apraxia of the right hand. Brain MRI disclosed T2-weighted and diffusion-weighted hyperintense lesions with reduced apparent diffusion coefficients in the bilateral centrum semiovale, splenium of the corpus callosum, right posterior limb of the internal capsule, and bilateral middle cerebellar peduncles. As the MRI findings vanished, his interhemispheric disconnection signs gradually resolved. Abdominal imaging studies revealed a pancreatic tumor, which was later endocrinologically diagnosed as an insulinoma. This is an extremely rare report of interhemispheric disconnection signs due to hypoglycemic encephalopathy. The lesions in the bilateral centrum semiovale likely contributed to the interhemispheric disconnection signs.. |
| 77. |
Miyaji, Naruhito Hironaga, Hiroshi Shigeto, Neuromagnetic detection of the laryngeal area: Sensory-evoked fields to air-puff stimulation., Neuroimage, 88, 169-169, 2013.11. |
| 78. |
Yuji Kanamori, Hiroshi Shigeto, Naruhito Hironaga, Koichi Hagiwara, Taira Uehara, Hiroshi Chatani, Ayumi Sakata, Kimiaki Hashiguchi, Takato Morioka, Shozo Tobimatsu, Jun-Ichi Kira, Minimum norm estimates in MEG can delineate the onset of interictal epileptic discharges: A comparison with ECoG findings., NeuroImage. Clinical, 10.1016/j.nicl.2013.04.008, 2, 663-9, 2013.11, The analysis of epileptic discharges in magnetoencephalography with minimum norm estimates (MNE) is expected to provide more precise localization of epileptic discharges compared with electroencephalographic estimations. However, the clinical feasibility of MNE remains unclear. In this study, we aimed to elucidate the onset and propagation patterns of interictal spikes using MNE. Seven patients with intractable epilepsy whose epileptogenicity was assumed to exist in the convexity of the cerebral cortex were studied. For MNE and electrocorticography (ECoG), we characterized the propagation patterns of interictal epileptic discharges according to the area in which they originated and where they extended; we then examined whether the propagation patterns observed in MNE were identified by ECoG. We also examined the relationship between the positions of spikes estimated by the equivalent current dipole (ECD) method and MNE. Among the seven patients, nine propagation patterns of epileptic discharges were observed by MNE, all of which were also identified by ECoG. In seven patterns, the epileptic activity propagated around the initial portion. However, in two patterns, the center of activities moved according to propagation with maintained activity of the initial portion. The locations of spikes identified by the ECD method were within the areas estimated by MNE when the epileptic activity propagated. However, the ECD method failed to detect onset activities identified by MNE in three of nine patterns. Thus, MNE is more useful as a means of presurgical evaluation for epilepsy than the ECD method because it can delineate the onset of epileptic activities as shown in ECoG.. |
| 79. |
Nobutaka Mukae, Takato Morioka, Tetsuro Sayama, Takeshi Hamamura, Kosuke Makihara, Hiroshi Shigeto, Tomio Sasaki, Traumatic medial temporal lobe epilepsy associated with a subcortical lesion in the internal capsule - A case report, Epilepsy and Seizure, 10.3805/eands.6.1, 6, 1, 1-9, 2013.11, Although there is no universally accepted definition, traumatic medial temporal lobe epilepsy (traumatic MTLE) can be generally defined as a type of post-traumatic epilepsy with medial temporal epileptogenicity. Previous studies have demonstrated that patients with traumatic MTLE frequently have hippocampal sclerosis (HS) coexisting with traumatic neocortical lesions. We report a 39-year-old MTLE patient with a subcortical lesion in the.internal capsule, suspected to be caused by mild diffuse axonal injury. The results of presurgical examinations and intraoperative electrocorticograms were consistent with a diagnosis of MTLE. Therefore, an anterior temporal lobectomy with hippocampectomy was performed. A 3D short tau inversion recovery 3-Tesla MRI scan clearly depicted possibly Wallerian degeneration in the temporal stem, which was continuous with the subcortical lesion. We speculate that Wallerian degeneration in the temporal stem could potentially involve the hippocampus, eventually leading to HS.. |
| 80. |
Hiroshi Shigeto, 鎌田 崇嗣, Spontaneous seizures in a rat model of multiple prenatal freeze lesioning, Epilepsy Res., 10.1016/j.eplepsyres.2013.03.003, 105, 3, 280-291, 2013.08, Focal cortical dysplasia (FCD) is an important cause of intractable epilepsy. Previous rat studies have utilized freeze lesioning of neonatal animals to model FCD; however, such models are unable to demonstrate spontaneous seizures without seizure-provoking events. Therefore, we created an animal model with multiple FCD, produced during embryonic development, and observed whether spontaneous seizures occurred. Furthermore, we examined the relationship between FCD and epileptogenesis using immunohistochemistry. At 18 days postconception, a frozen metal probe was placed bilaterally on the scalps of Sprague-Dawley rat embryos through the uterus wall to produce multiple FCD. Electroencephalogram (EEG) and video recording were performed from postnatal day (P) 35 to P77. Brain tissues were examined immunohistochemically at P28 and P78 using semiquantitative densitometry. Eleven of 16 rats (68.8%) showed spontaneous seizures arising in the hippocampus from P47. Movement cessation followed by sniffing and mastication, culminating in wet-dog shaking, was seen during the hippocampal EEG discharges. FCD was observed in the bilateral frontoparietal lobes. The expression levels of N-methyl-d-aspartate receptor (NMDAR) subunits 1, 2A, 2B, the glutamate/aspartate transporter and the glial glutamate transporter 1 (GLT1) at FCD sites were increased at P28 and P78. There were no major histological abnormalities in the hippocampi compared with those in the cortex. However, the expression levels of NMDAR 2A and 2B were increased at P28. Levels of NMDAR1, 2A and 2B, the glutamate/aspartate transporter and GLT1 were also increased at P78. We created an animal model showing spontaneous seizures without a provoking event except for the existence of cortical dysplasia, and without a genetic or general systematic cause like MAM injection or irradiation. The seizures resembled human temporal lobe epilepsy both clinically and on EEG. Alterations in the levels of glutamatergic and GABAergic receptors were investigated during growth. This model should enable better clarification of the mechanisms underlying the development of human epilepsy.. |
| 81. |
Noriko Yutsudo, Takashi Kamada, Kosuke Kajitani, Hiroko Nomaru, Atsuhisa Katogi, Yoko H. Ohnishi, Yoshinori N. Ohnishi, Kei Ichiro Takase, Sakumi Kunihiko, Hiroshi Shigeto, Yusaku Nakabeppu, Erratum FosB-null mice display impaired adult hippocampal neurogenesis and spontaneous epilepsy with depressive behavior (Neuropsychopharmacology (2013) 38 (1374-1375) DOI: 10.1038/npp.2013.56), Neuropsychopharmacology, 10.1038/npp.2013.56, 38, 7, 1374-1375, 2013.06. |
| 82. |
Noriko Yutsudo, Takashi Kamada, Kosuke Kajitani, Hiroko Nomaru, Atsuhisa Katogi, Yoko H Ohnishi, Yoshinori N Ohnishi, Kei-ichiro Takase, Kunihiko Sakumi, Hiroshi Shigeto, Yusaku Nakabeppu, fosB-null mice display impaired adult hippocampal neurogenesis and spontaneous epilepsy with depressive behavior., Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 10.1038/npp.2012.260, 38, 5, 895-906, 2013.04, Patients with epilepsy are at high risk for major depression relative to the general population, and both disorders are associated with changes in adult hippocampal neurogenesis, although the mechanisms underlying disease onset remain unknown. The expression of fosB, an immediate early gene encoding FosB and ΔFosB/Δ2ΔFosB by alternative splicing and translation initiation, is known to be induced in neural progenitor cells within the subventricular zone of the lateral ventricles and subgranular zone of the hippocampus, following transient forebrain ischemia in the rat brain. Moreover, adenovirus-mediated expression of fosB gene products can promote neural stem cell proliferation. We recently found that fosB-null mice show increased depressive behavior, suggesting impaired neurogenesis in fosB-null mice. In the current study, we analyzed neurogenesis in the hippocampal dentate gyrus of fosB-null and fosB(d/d) mice that express ΔFosB/Δ2ΔFosB but not FosB, in comparison with wild-type mice, alongside neuropathology, behaviors, and gene expression profiles. fosB-null but not fosB(d/d) mice displayed impaired neurogenesis in the adult hippocampus and spontaneous epilepsy. Microarray analysis revealed that genes related to neurogenesis, depression, and epilepsy were altered in the hippocampus of fosB-null mice. Thus, we conclude that the fosB-null mouse is the first animal model to provide a genetic and molecular basis for the comorbidity between depression and epilepsy with abnormal neurogenesis, all of which are caused by loss of a single gene, fosB.. |
| 83. |
Yuji Kanamori, Hiroshi Shigeto, Minimum norm estimates in MEG can delineate the onset of interictal epileptic discharges: A comparison with ECoG findings, Neuroimage Clin., 2013.04. |
| 84. |
Hiroshi Shigeto, Atthaporn Boongird, Kenneth Baker, Christoph Kellinghaus, Imad Najm, Hans Lüders, Systematic study of the effects of stimulus parameters and stimulus location on afterdischarges elicited by electrical stimulation in the rat., Epilepsy research, 10.1016/j.eplepsyres.2012.10.002, 104, 1-2, 17-25, 2013.03, Electrical brain stimulation is used in a variety of clinical situations, including cortical mapping for epilepsy surgery, cortical stimulation therapy to terminate seizure activity in the cortex, and in deep brain stimulation therapy. However, the effects of stimulus parameters are not fully understood. In this study, we systematically tested the impact of various stimulation parameters on the generation of motor symptoms and afterdischarges (ADs). Focal electrical stimulation was delivered at subdural cortical, intracortical, and hippocampal sites in a rat model. The effects of stimulus parameter on the generation of motor symptoms and on the occurrence of ADs were examined. The effect of stimulus irregularity was tested using random or regular 50Hz stimulation through subdural electrodes. Hippocampal stimulation produced ADs at lower thresholds than neocortical stimulation. Hippocampal stimulation also produced significantly longer ADs. Both in hippocampal and cortical stimulation, when the total current was kept constant with changing pulse width, the threshold for motor symptom or AD was lowest between 50 and 100Hz and higher at both low and high frequencies. However, if the pulse width was fixed, the threshold did not increase above 100Hz and it apparently continued to decrease through 800Hz even if the difference did not reach statistical significance. There was no significant difference between random and regular stimulation. Overall, these results indicate that electrode location and several stimulus parameters including frequency, pulse width, and total electricity are important in electrical stimulation to produce motor symptoms and ADs.. |
| 85. |
河村信利, 河村信利, 米川智, 松下拓也, 重藤寛史, 大八木保政, 吉良潤一, Combined central and peripheral demyelination(CCPD)における抗neurofascin抗体, 末梢神経, 23, 2, 2012.11. |
| 86. |
Koichi Hagiwara, Katsuya Ogata, Naruhito Hironaga, Shozo Tobimatsu, Tsuyoshi Okamoto, Taira Uehara, Hiroshi Shigeto, Neuromagnetic changes of the somatosensory information processing in normal aging, 2012 ICME International Conference on Complex Medical Engineering, CME 2012 Proceedings, 10.1109/ICCME.2012.6275666, 551-556, 2012.11, Age-related electrophysiological changes in the primary somatosensory cortex (SI) are well known. There is evidence that the amplitude of the N20 component of median nerve somatosensory evoked potentials typically increases with age, probably because of cortical disinhibition. The secondary somatosensory cortex (SII) receives dual input from the SI and the thalamus. We quantified age-related changes both in SI and SII using magnetoencephalography (MEG). We recorded somatosensory evoked magnetic fields (SEFs) to median nerve stimulation in 15 young adults (aged 22-36 years, mean age 29.0±4.1) and 15 older adults (aged 52-67 years, mean age 61.9±5.4), and analysed major SEF components in SI and SII. The amplitude and equivalent current dipole (ECD) strength of the N20m were significantly increased in the older adults, consistent with the well-known electrophysiological change for cortical disinhibition in SI. The latency of N20m showed a trend for increase in older subjects, possibly reflecting slowing of conduction velocity in the peripheral nerves. In contrast, SII response (response peak at around 80-120 ms) showed a different change in aging. Latencies of the contralateral SII responses showed a trend for shortening in the older adults. There were no significant age-related changes for the amplitudes and ECD strengths. Thus, SI and SII are differently affected by aging. The shortening of the SII latency suggests age-related plastic-adaptive change in SII, which is mediated by the direct thalamocortical pathway. © 2012 IEEE.. |
| 87. |
村上信哉, 森岡隆人, 橋口公章, 重藤寛史, 酒田あゆみ, 天野敏之, 中溝玲, 秦暢宏, 佐々木富男, 頭皮上脳波モニタリングで側方性の診断が困難であった内側側頭葉てんかん:低侵襲慢性深部電極同時記録による解析, 日本てんかん外科学会プログラム・抄録集, 36th, 2012.11. |
| 88. |
重藤寛史, 吉良潤一, 大八木保政, 食品を介したダイオキシン類等の人体への影響の把握とその治療法の開発等に関する研究 感覚認知機能の客観的評価法の開発, 食品を介したダイオキシン類等の人体への影響の把握とその治療法の開発等に関する研究 平成21-23年度 総合研究報告書 平成23年度 総括・分担研究報告書, 2012.11. |
| 89. |
Sanefuji M, Hiroshi Shigeto, Toshiro Hara, A case of childhood stiff-person syndrome with striatal lesions: A possible entity distinct from the classical adult form, Brain Dev, 10.1016/j.braindev.2012.08.003, 35, 6, 575-8, 2012.08, Parainfectious or autoimmune striatal lesions have been repeatedly described in children. We report a 7-year-old girl with painful muscle spasms, leading to the diagnosis of childhood stiff-person syndrome (SPS). Striatal lesions were demonstrated by diffusion-weighted magnetic resonance imaging (MRI) and single-photon emission computed tomography but not by conventional MRI. Autoantibodies against glutamic acid decarboxylase (GAD) were absent. Steroid pulse therapy and high-dose intravenous immunoglobulin resolved all the symptoms with slight sequelae. Childhood SPS may be characterized by absent anti-GAD antibodies and a transient benign clinical course, and it may have a pathomechanism distinct from that in adult SPS.. |
| 90. |
Noriko Isobe, Hiroshi Shigeto, Jun-ichi Kira, First diagnostic criteria for atopic myelitis with special reference to discrimination from myelitis-onset multiple sclerosis., J Neurol Sci., 10.1016/j.jns.2012.02.007, 316, 1-2, 30-35, 2012.05, OBJECTIVE: To establish the first evidence-based diagnostic criteria for atopic myelitis (AM) enabling it to be discriminated from myelitis-onset multiple sclerosis (MS), which is a difficult differential diagnosis. METHODS: Sixty-nine consecutive AM patients examined from 1996 to 2010 at Kyushu University hospital, who fulfilled the empirical definition of AM (2003), and 51 myelitis-onset MS patients in whom allergen-specific IgE was measured, were enrolled. The first available brain MRI findings were compared between the two. Then, we compared the clinical and laboratory features between the 16 AM cases who did not meet the Barkhof brain MRI criteria for MS after more than 5 years follow-up and 51 myelitis-onset MS cases. Based on the discriminative findings, we established diagnostic criteria for AM and calculated the sensitivity and specificity. RESULTS: AM patients had a significantly lower frequency of Barkhof brain lesions on baseline MRI than myelitis-onset MS patients. AM patients had a significantly higher frequency of present and/or past history of atopic disease and hyperIgEemia, and higher cerebrospinal fluid levels of interleukin 9 and CCL11/eotaxin, but a lower frequency of oligoclonal IgG bands than myelitis-onset MS patients. Our proposed diagnostic criteria for AM demonstrated 93.3% sensitivity and 93.3% specificity for AM against myelitis-onset MS, with 82.4% positive predictive value and 97.7% negative predictive value. CONCLUSION: Our first evidence-based criteria for AM show high sensitivity and specificity, and would be useful clinically.. |
| 91. |
Saiga, Hiroshi Shigeto, Tateishi, Ohyagi, Inflammatory radiculoneuropathy in an ALS4 patient with a novel SETX mutation., J Neurol Neurosurg Psychiatry, 10.1136/jnnp-2012-302281, 83, 7, 763-764, 2012.05. |
| 92. |
Tomonori Iwata, Hiroshi Shigeto, Katsuya Ogata, Ko-ichi Hagiwara, Yuji Kanamori, Taira Uehara, Yasumasa Ohyagi, Shozo Tobimatsu, Jun-ichi Kira, Hyperexcitability restricted to the lower limb motor system in a patient with stiff-leg syndrome., Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia, 10.1016/j.jocn.2011.03.021, 18, 12, 1720-2, 2011.12, We report a 29-year-old man who presented with a 2-year history of progressive stiffness and painful spasms limited to the bilateral lower limbs, exaggerated by auditory and tactile stimuli. His deep tendon reflexes were slightly increased in both lower extremities. His plantar response was flexor. His serum and cerebrospinal fluid were negative for anti-glutamic acid decarboxylase antibodies. Electromyography of antagonist muscle pairs in his distal lower limbs revealed a failure of reciprocal inhibition. We used transcranial magnetic stimulation with a paired-pulse paradigm, delivered to the cortical area of the upper and lower limbs, and revealed significantly enhanced facilitation only in the area of his lower limbs, but not that representing his upper limbs. His symptoms were improved substantially by 20mg/day of oral diazepam. To our knowledge this is the first report of a patient with hyperexcitability limited to the lower limb motor system in a patient with stiff-leg syndrome.. |
| 93. |
重藤 寛史, シンポジウム１５‐４ 最新のてんかんの病態と治療 てんかん治療の最前線, 臨床神経学, 10.5692/clinicalneurol.51.997, 51, 11, 997-9, 2011.11. |
| 94. |
Noriko Yutsudo, Takashi Kamada, Hiroko Nomaru, Yoko H. Ohnishi, Yoshinori N. Ohnishi, Kosuke Kajitani, Kunihiko Sakumi, Hiroshi Shigeto, Yusaku Nakabeppu, Delta FosB and/or Delta 2 Delta FosB regulate proliferation of adult hippocampal neural progenitor cells and suppress spontaneous epileptic seizures, NEUROSCIENCE RESEARCH, 10.1016/j.neures.2011.07.1289, 71, E295-E295, 2011.11. |
| 95. |
Taira Uehara, Hiroyuki Murai, Ryo Yamasaki, Hitoshi Kikuchi, Hiroshi Shigeto, Yasumasa Ohyagi, Jun-Ichi Kira, Thymoma-associated progressive encephalomyelitis with rigidity and myoclonus successfully treated with thymectomy and intravenous immunoglobulin., European neurology, 10.1159/000332033, 66, 6, 328-30, 2011.11. |
| 96. |
則内まどか, 則内まどか, 菊池吉晃, 吉浦敬, 吉良龍太郎, 吉良龍太郎, 重藤寛史, 原寿郎, 飛松省三, 神尾陽子, 拡散テンソル画像を用いた社会性の障害に関する研究-自閉症スペクトラム障害児の白質構造-, 日本生理人類学会誌, 16, 2011.11. |
| 97. |
重藤寛史, 吉良潤一, 大八木保政, 食品を介したダイオキシン類等の人体への影響の把握とその治療法の開発等に関する研究 油症患者の自覚症状と他覚的神経障害の変化の検討, 食品を介したダイオキシン類等の人体への影響の把握とその治療法の開発等に関する研究 平成22年度 総括・分担研究報告書, 2011.11. |
| 98. |
Kei-ichiro Takase, Hiroshi Shigeto, Kohnosuke Furuta, Nobutaka Sakae, Yasumasa Ohyagi, Jun-ichi Kira, Transient vocal cord palsy caused by hypoperfusion of unilateral hemisphere., Fukuoka igaku zasshi = Hukuoka acta medica, 102, 9, 273-6, 2011.09, We report a 68-year-old man who exhibited mild dysarthria and mild right hemiparesis resulted from hypoperfusion of the left hemisphere. An MR angiography showed a severe stenosis at the second portion of left middle cerebral artery (MCA). After the beginning of treatment, the patient suffered from hoarseness, followed by breathing failure. The laryngeal fiber exhibited right vocal cord paresis. Unilateral cortico-bulbar tract dysfunction does not typically cause vocal cord palsy. However, several cases indicate the involvement of a dominant projection from the contralateral cortico-bulbar tract to the vocal cord. In the present case, hypoperfusion of the left hemisphere might have temporarily produced right vocal cord palsy, considering the stenosis of the left MCA.. |
| 99. |
重藤 寛史, 神経内科医としてのてんかん診療, 臨床神経学, 10.5692/clinicalneurol.51.661, 51, 9, 661-8, 2011.09, てんかんは総人口の約1％が罹患するありふれた疾患である．てんかん診断のためには発作症候を知り，正しい脳波判読をすることが大切である．治療の基本は抗てんかん薬治療であり，ここ数年で日本での処方が可能となった新規抗てんかん薬もふくめ副作用や相互作用を良く知って処方する必要がある．一方，海馬硬化を有する側頭葉てんかんなど，早めに外科治療を考慮すべきてんかんもある．成人てんかん患者は就労，結婚，妊娠・出産，合併疾患など様々な要因をもっている．本総説では新規抗てんかん薬，てんかん手術，女性のてんかん，高齢者のてんかん，などのトピックもふくめ神経内科医として必要なてんかん診療の基本を概説する．
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| 100. |
緒方 英紀, 重藤 寛史, 鳥居 孝子, 河村 信利, 大八木 保政, 吉良 潤一, 梅毒性視神経炎に合併したＣｈａｒｌｅｓ Ｂｏｎｎｅｔ症候群の１例, 臨床神経学, 10.5692/clinicalneurol.51.595, 51, 8, 595-8, 2011.08, 症例は62歳男性である．数カ月間で両側視力障害が急速に進行．視力は右0.03，左光覚弁．両側視神経萎縮，両下肢で腱反射低下と振動覚低下をみとめた．血清と髄液の梅毒抗体価が高値であり，梅毒性視神経炎としてpenicillin Gを投与したが視力の回復はなかった．経過中，明瞭で複雑な幻視が出現．認知機能は正常で他の幻覚や妄想はみとめずCharles Bonnet症候群と診断した．頭部MRIでびまん性大脳萎縮および斑状の白質病変，脳血流SPECTで右側優位に後頭葉内側の血流低下をみとめた．オランザピン投与にて幻視の出現頻度は減少した．本症候群の病態への後頭葉機能低下の関与を示唆する貴重な症例と考えた．
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| 101. |
重藤 寛史, てんかんの初期診療と最近のトピックス, 福岡醫學雜誌, 10.15017/19872, 102, 6, 195-202, 2011.06, type:総説
type:Review Article. |
| 102. |
Kawano Y, Shigeto H, Shiraishi Y, Ohyagi Y, Kira J., Case of Borrelia brainstem encephalitis presenting with severe dysphagia., Rinsho Shinkeigaku, 10.5692/clinicalneurol.50.265, 50, 4, 265-267, 2011.05, 症例は30歳男性である．嚥下障害，複視，ふらつきにて発症し，吃逆も出現．軽度意識混濁，左側優位の眼瞼下垂，左注視方向性眼振，両側眼輪筋と口輪筋の軽度脱力，体幹失調をみとめた．嚥下反射は著明に亢進し，嚥下困難を呈していた．脳波は間欠性に全般性に高振幅徐波が出現し，脳幹脳炎と考えられた．しかし血算，血液生化学，髄液検査，頭部MRIに異常をみとめなかった．副腎皮質ステロイド剤は吃逆，複視，眼瞼下垂を改善したが，その他の症状に無効．免疫グロブリン療法も無効であった．その後，抗ボレリア抗体陽性が判明し，抗生剤投与にてすみやかに改善した．通常の免疫療法への反応に乏しい脳幹脳炎ではボレリア感染も考慮すべきである．
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| 103. |
上田 麻紀, 河村 信利, 立石 貴久, 重藤 寛史, 大八木 保政, 吉良 潤一, 後天性ｖｏｎ Ｗｉｌｌｅｂｒａｎｄ症候群をともなった慢性炎症性脱髄性多発根ニューロパチーの１例, 臨床神経学, 10.5692/clinicalneurol.51.334, 51, 5, 334-7, 2011.05, 症例は47歳男性である．33歳時に慢性炎症性脱髄性多発根ニューロパチー（CIDP）と診断され，免疫療法にて症状は安定していた．47歳時に後天性von Willebrand症候群（AvWS），大腸癌，M蛋白血症を指摘された．出血傾向に対し第VIII因子補充は無効だったが免疫グロブリン大量静注療法（IVIg）が著効し，腫瘍切除された．術後にCIDPの増悪，出血時間延長，von Willebrand因子活性低下をみとめ，M蛋白血症をともなったCIDPとAvWSの再燃と診断．IVIgにて神経症状と出血時間の改善がみられた．本例のようなCIDPではAvWSと共通の自己免疫病態が存在している可能性がある．
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| 104. |
松山 友美, 重藤 寛史, 佐竹 真理恵, 高齢初発非けいれん性全般てんかん重積状態の１例, 臨床神経学, 10.5692/clinicalneurol.51.43, 10.1002/ncn3.6_references_DOI_Dc0DC8QRi4N2FhXeZJON9hVnnrF, 10.5692/clinicalneurol.51.661_references_DOI_Dc0DC8QRi4N2FhXeZJON9hVnnrF, 51, 1, 43-46, 2011.01, 症例は78歳女性である．75歳時意識消失をともなう全身けいれん発作を初発．78歳の5月，両上肢のミオクローヌスが覚醒後に2～3回みられた．6月下旬にふらつきが強く3日間入院，安静にて軽快．7月中旬にふたたびふらつきが出現し当科初診．JCS 2の意識障害，軽度体幹失調がみられた．血液，脳脊髄液，頭部MRIに異常なし．脳波で持続1～2秒の全般性棘徐波・多棘徐波複合が2～4秒おきに出現．非けいれん性全般てんかん重積状態と判断しジアゼパム5mg静注にててんかん性放電消失，以後バルプロ酸400mg/日投与をおこない症状は改善し発作間欠期てんかん性放電も著減した．高齢発症の非けいれん性全般てんかん重積状態はまれであり若干の考察を加え報告する．
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| 105. |
Madoka Noriuchi, Yoshiaki Kikuchi, Takashi Yoshiura, Ryutaro Kira, Hiroshi Shigeto, Toshiro Hara, Shozo Tobimatsu, Yoko Kamio, Altered white matter fractional anisotropy and social impairment in children with autism spectrum disorder, BRAIN RESEARCH, 10.1016/j.brainres.2010.09.051, 1362, 141-149, 2010.11, Individuals with autism spectrum disorder (ASD) have severe difficulties in social interaction and communication, as well as restricted and/or stereotyped patterns of behavior. Previous studies have suggested that abnormal neural connectivity might be associated with higher information processing dysfunction involving social impairment. However, the white matter structure in ASD is poorly understood. To explore this, we conducted a voxel-based, whole-brain diffusion tensor imaging (DTI) analysis to determine fractional anisotropy (FA), lambda(1), lambda(2) and lambda(3) in high-functioning children with ASD compared with age-, gender-, and handedness-matched healthy control participants. We then investigated whether DTI parameters were associated with behaviorally measured social function. We found that FA and lambda(1) were significantly lower in the ASD group than in the control group in the white matter around left dorsolateral prefrontal cortex (DLPFC), posterior superior temporal sulcus/temporo-parietal junction, right temporal pole, amygdala, superior longitudinal fasciculus, occipitofrontal fasciculus, mid- and left anterior corpus callosum, and mid- and right anterior cingulate cortex. The FA value in the left DLPFC was negatively correlated with the degree of social impairment in children with ASD. Higher values were observed in the cerebellar vermis lobules in the ASD group. The white matter alterations in children with ASD were around cortical regions that play important roles in social cognition and information integration. These DTI results and their relationship to social impairment add to evidence of cerebral and cerebellar white matter structural abnormalities in ASD. (C) 2010 Elsevier B.V. All rights reserved.. |
| 106. |
重藤寛史, 寳珠山稔, SEP-体性感覚誘発反応の理解を深める-, 臨床神経生理学, 38, 5, 2010.11. |
| 107. |
吉良潤一, 大八木保政, 重藤寛史, 萩原綱一, 飛松省三, スモンに関する調査研究 脳磁図による高次脳機能解析(2), スモンに関する調査研究班 平成21年度総括・分担研究報告書, 2010.11. |
| 108. |
橋口公章, 森岡隆人, 森岡隆人, 村上信哉, 金森祐治, 萩原綱一, 染原裕子, 重藤寛史, 天野敏之, 佐々木富男, 新皮質てんかんにおけるMEG双極子分布と頭皮上脳波・皮質電位におけるてんかん原性域との関係:後方視的解析による評価, 日本てんかん外科学会プログラム・抄録集, 34th, 2010.11. |
| 109. |
重藤寛史, 瀬川義朗, 脳死の脳波記録, 臨床神経生理学, 38, 5, 2010.11. |
| 110. |
Yutsudo Noriko, Kamada Takashi, Honda-Ohnishi Yoko, Ohnishi Yoshinori, Kajitani Kosuke, Sakumi Kunihiko, Shigeto Hiroshi, Nakabeppu Yusaku, fosB-null mice exhibit impaired adult hippocampal neurogenesis and spontaneous epileptic seizures, NEUROSCIENCE RESEARCH, 10.1016/j.neures.2010.07.1859, 68, E419-E419, 2010.10. |
| 111. |
上田 麻紀, 立石 貴久, 重藤 寛史, 山崎 亮, 大八木 保政, 吉良 潤一, インフリキシマブ治療中にＥｐｓｔｅｉｎ－Ｂａｒｒウイルス再活性化にともなって急性散在性脳脊髄炎を発症した１例, 臨床神経学, 10.5692/clinicalneurol.50.461, 50, 7, 461-466, 2010.07, 症例は31歳女性である．クローン病に対してインフリキシマブ投与開始11カ月後に無菌性髄膜炎を発症し一時軽快したが，その後に体幹失調や球麻痺が出現した．髄液検査では単核球優位の細胞数増多，ミエリン塩基性蛋白とIgG indexが上昇しており血清のEpstein-Barrウイルス（EBV）抗体は既感染パターンを示し，髄液・血液PCRにてEBV-DNAを検出した．MRIにて脳幹，大脳皮質下白質，頸髄に散在性にT2高信号病変をみとめ急性散在性脳脊髄炎（ADEM）と診断した．各種免疫治療に抵抗性であったが，ステロイドパルス療法を反復し症状は改善した．抗TNF-α抗体製剤の副作用による脱髄が報告されているが，本症例は抗TNF-α抗体製剤投与中のEBV再活性化によって惹起されたADEMと考えられた．
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| 112. |
鮫島 祥子, 立石 貴久, 荒畑 創, 重藤 寛史, 大八木 保政, 吉良 潤一, 抗Ｈｕ抗体，抗ＧｌｕＲε２抗体ともに陽性で辺縁系脳炎を合併した末梢神経障害の１例, 臨床神経学, 10.5692/clinicalneurol.50.467, 50, 7, 467-472, 2010.07, 症例は75歳男性である．74歳時に歩行困難，全身痙攣のため前医に入院したが，意識障害，四肢筋力低下が遷延し当科へ転院した．入院時に意識障害，遠位筋優位の筋萎縮，筋力低下をみとめ，頭部MRIで両側海馬にT2高信号域を，神経伝導検査で運動神経優位の末梢神経障害をみとめた．胸部CTにて肺門部のリンパ節腫脹と同部位へのFDG-PETでの集積をみとめた．血清抗Hu抗体，抗GluRε2抗体が陽性で，傍腫瘍性神経症候群による辺縁系脳炎，末梢神経障害が示唆された．免疫グロブリン大量静注療法（IVIg）を施行し，臨床症状，検査所見ともに改善した．複数の抗神経抗体陽性例の報告はまれで，抗Hu抗体と抗GluRε2抗体の重複陽性例にてIVIgが有効である可能性が示唆された．
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| 113. |
Nakamura N, Shigeto H, Isobe N, Tanaka M, Ohyagi Y, Kira J., A case of mononeuropathy multiplex associated with idiopathic thrombocytopenic purpura, Rinsho Shinkeigaku, 50, 7, 482-484, 2010.07. |
| 114. |
中村 憲道, 重藤 寛史, 磯部 紀子, 田中 正人, 大八木 保政, 吉良 潤一, 特発性血小板減少性紫斑病に関連した多発単神経障害の１例, 臨床神経学, 10.5692/clinicalneurol.50.482, 50, 7, 482-4, 2010.07, 症例は78歳男性．某年7月，左前腕に紫斑が出現．血小板数1.1万/μl ，血小板関連自己抗体陽性であり，特発性血小板減少性紫斑病と診断された．翌月初旬より左手指および左下腿の脱力と異常感覚，両下腿外側の異常感覚が出現した．来院時所見では，左尺骨神経領域の感覚障害と筋力低下，両側浅腓骨神経領域の感覚障害，左前脛骨筋の筋力低下をみとめ多発単神経障害の病像を呈していた．ステロイド治療による血小板数の増加とともに脱力，感覚障害も改善した．特発性血小板減少性紫斑病に関連した多発単神経障害と考えられ，免疫学的機序による障害が推察された．
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| 115. |
Koichi Hagiwara, Tsuyoshi Okamoto, Hiroshi Shigeto, Katsuya Ogata, Yuko Somehara, Takuya Matsushita, Jun-ichi Kira, Shozo Tobimatsu, Oscillatory gamma synchronization binds the primary and secondary somatosensory areas in humans, NEUROIMAGE, 10.1016/j.neuroimage.2010.02.001, 51, 1, 412-420, 2010.05, Induced gamma activity has a key role in the temporal binding of distributed cortico-cortical processing. To elucidate the neural synchronization in the early-stage somatosensory processing, we studied the functional connectivity between the primary and secondary somatosensory cortices (SI and 511) in healthy subjects using magnetoencephalography (MEG) with excellent spatiotemporal resolution. First, somatosensory-evoked magnetic fields were recorded to determine the locations of each cortical activity. Then we analyzed the phase-locking values (PLVs) of the induced gamma activity to assess neural synchrony within the somatosensory cortical network. We also assessed PLVs in patients with multiple sclerosis (MS) to validate our PLV analysis in evaluating the inter-areal functional connectivity, which can often be impaired in MS. The PLVs of the induced gamma activity were calculated for each pair of unaveraged MEG signals that represented the activities of the contralateral SI and bilateral SII areas. Analysis of PLVs between the SI and SII areas showed significantly increased PLVs for gamma-band activities, starting at an early post-stimulus stage in normal controls, whereas this increase in PLVs was apparently diminished in MS. The PLV analysis provided evidence for early-latency, gamma-band neuronal synchronization between the SI and SII areas in normal controls. Our study first demonstrates the gamma-band synchrony in the early-stage human somatosensory processing. (C) 2010 Elsevier Inc. All rights reserved.. |
| 116. |
重藤 寛史, 吉良 潤一, てんかんのビデオ脳波モニタ—Video-EEG monitoring for epilepsy—第1土曜特集 てんかん治療Update--研究と臨床の最前線 ; 最新・てんかん診療動向 新しい診断, 医学のあゆみ, 232, 10, 1050-1055, 2010.03, ビデオ脳波モニタは、てんかんや意識消失発作を有する患者の発作症候、発作時の脳波活動、発作のない時期のてんかん性放電の出現部位と頻度をビデオと脳波で長時間同時記録する検査で、てんかん診断のみならず失神や転換性障害との鑑別に大きな役割を果たす。また、てんかんの手術治療を目的とする場合は、てんかん原性がどこに存在するかを調べる検査として不可欠である。ビデオ脳波の解析には発作のポイントとなる症候を把握し、脳波を正しく判読することが重要である。長時間を要する検査なので、患者の理解と看護師や脳波検査技師の協力が必要である。(著者抄録). |
| 117. |
Hirokazu Furuya, Koji Ikezoe, Hiroshi Shigeto, Yasumasa Ohyagi, Hajime Arahata, Ei-ichi Araki, Naoki Fujii, Sleep- and Non-Sleep-Related Hallucinations-Relationship to Ghost Tales and Their Classifications, DREAMING, 10.1037/a0017611, 19, 4, 232-238, 2009.12, To categorize four types of sleep- and non-sleep-related hallucinations experienced by normal people and classify ghost or ghost-like stories by these categories. A total of 183 reliable tales of ghosts [41 from "Tohno Monogatari" (Tohno Folktales) and 142 from "Nihon Kaidan Shu" (Ghosts Tales of Japan)] are classified into hallucinations that are sleep-related hallucinations [hypnagogic hallucination-like (HyH) and REM sleep behavior disorder or somnambulism-like (RBDS) tales] and sleep-unrelated [vivid hallucination-like (VH) and highway hypnosis-like (HHy) tales] according to the criteria. Sixty to 70% of these tales can be classified into these four types of hallucinations. Further, sleep-related hallucinations increased from 17.0% to 36.6% in about 40 years. Our criteria will be useful to classify hallucinations experienced by normal people and to elucidate the mechanisms of these kinds of hallucinations experienced in neurodegenerative or psychological disorders.. |
| 118. |
Kazuhiro Samura, Takato Morioka, Kimiaki Hashiguchi, Yasushi Miyagi, Hiroshi Shigeto, Ayumi Sakata, Shigeya Tanaka, Temporal lobe epilepsy associated with ‘triple pathology’ of hippocampal sclerosis, focal cortical dysplasia and cavernoma in the ipsilateral frontal lobe, Epilepsy and Seizure, 10.3805/eands.2.34, 2, 1, 34-41, 2009.12, The coexistence of hippocampal sclerosis (HS) and extrahippocampal lesions such as focal cortical dysplasia (FCD) and cavernoma (CA) in temporal lobe epilepsies (TLE) is termed ‘dual pathology’. We report a case of TLE having ‘triple pathology’ of HS, FCD and CA in the ipsilateral frontal lobe. Using chronic subdural electrode recording, an interictal electrocorticogram (ECoG) demonstrated that the medial temporal lobe lesion and the FCD lesion exhibited independent paroxysmal discharges, while an ictal ECoG demonstrated that the medial temporal lobe was the ictal on-set zone. We postulated that the FCD lesion caused repeated seizures, which in turn, caused secondary hippocampal damage and HS, and eventually medically intractable epilepsy. The coexistence of CA was considered incidental. As treatments, the epileptogenic HS was resected through an anterior temporal lobectomy, and the FCD lesion was biopsied, while no surgical intervention was performed for the CA lesion. The patient achieved good seizure control during 12 months after surgery. Chronic subdural electrode recording is important for the assessment of multiple epileptogenic lesions before epilepsy surgery.. |
| 119. |
吉良潤一, 大八木保政, 重藤寛史, 萩原綱一, 飛松省三, スモンに関する調査研究班 脳磁図による高次脳機能解析(1), スモンに関する調査研究班 平成20年度総括・分担研究報告書, 2009.11. |
| 120. |
高瀬敬一郎, 重藤寛史, 鈴木諭, 菊池仁志, 大八木保政, 吉良潤一, ラット胎生期に作製した局所皮質異形成モデルにおけるてんかん原性の検討, てんかん研究, 27, 2, 2009.11. |
| 121. |
橋口公章, 森岡隆人, 左村和宏, 村上信哉, 宮城靖, 重藤寛, 酒田あゆみ, 藤本明子, 佐々木富男, 発作時頭皮上脳波所見と画像所見との側方性が異なる内側側頭葉てんかんの2手術例:深部電極による頭蓋内脳波記録と電気刺激からの病態解析, 臨床神経生理学, 37, 5, 2009.11. |
| 122. |
重藤 寛史, てんかんに対するルーチン検査としての脳磁図の有用性と限界, 臨床脳波 51, 51, 10, 626-631, 2009.10, 術前の評価だけではなく、てんかん診断という視点から局在関連てんかん患者85名の脳磁図結果を解析した。68名(80%)でてんかん性異常が検出され、うち7例(8.2%)では同時記録した脳波で捉えられなかった活動を検出できた。磁界から推定した電流源は、症状・神経放射線画像から推定されたてんかん原領域と一致する脳葉に存在した。17例(20%)で脳磁図、脳波とも1回の検査ではてんかん性異常を検出できなかったが、うち15例は複数回あるいは長時間脳波モニタリングでてんかん性異常が記録されていた。脳磁図も非服薬下での検査や複数回の検査を行うことが必要と考えられた。(著者抄録). |
| 123. |
高瀬 敬一郎, 重藤 寛史, 鎌田 崇嗣, Ohyagi Yasumasa, Kira Jun-ichi, 皮質てんかんラットモデルでの視床背内側核刺激の効果, 福岡医学雑誌, 10.15017/15638, 100, 8, 274-280, 2009.08, 背景 視床背内側核は前頭葉と辺縁系とに強く結合している。この研究では、前頭葉への電気刺激で励起されるてんかん発作に対し、視床背内側核電気刺激が影響を与えるか否かを検討した。対象と方法 生後28日目の成熟雄ラット(n=7)の脳表(両側前頭葉)にネジ電極を、両側視床背内側核に深部電極を埋め込み、10日間休ませた後38日目から1日1回前頭葉の電極に電気刺激を行い、全身けいれん発作を出現させた。刺激は明らかな後放電(前頭葉の脳表からのてんかん性放電)が出現するまで、徐々に上昇させ、後放電が出現した時点で刺激を終了した。また、一定の刺激電圧(0.1mA)で視床背内側核電気刺激を0Hz、1Hz、5Hz、10Hzの周波数で各ラットに前頭葉刺激と同時に1日おきに行った。それぞれの群で後放電の閾値と持続時間を計測し比較した。結果 けいれん発作は両側前頭葉の棘波とそれに伴う全身強直間代性けいれんであった。後放電の閾値には4群間で有意な差を認めなかった。持続時間に関しては10Hz刺激でコントロール群より軽度短かったものの、全体として有意差を認めなかった。結論 視床背内側核の電気刺激は、今回のような低頻度刺激ではてんかん発作を抑制することは難しいと思われる。今後視床刺激の部位や頻度を変更する必要がある。(著者抄録). |
| 124. |
Akihiro Watanabe, Takuya Matsushita, Hikaru Doi, Takashi Matsuoka, Hiroshi Shigeto, Noriko Isobe, Yuji Kawano, Shozo Tobimatsu, Jun-ichi Kira, Multi modality-evoked potential study of anti-aquaporin-4 antibody-positive and -negative multiple sclerosis patients, JOURNAL OF THE NEUROLOGICAL SCIENCES, 10.1016/j.jns.2009.02.371, 281, 1-2, 34-40, 2009 Jun 15;281(1-2):34-40. Epub 2009 Apr 1.
, 2009.06, Neuromyelitis optica (NMO) is claimed to be a distinct disease entity from multiple sclerosis (MS) because of its strong association with NMO-IgG/anti-AQP4 antibody; however, the in vivo role of the antibody remains unknown. Therefore, we aimed to clarify whether the presence of anti-AQP4 antibody is associated with any abnormalities in multimodality-evoked potentials in 111 patients with relapsing-remitting or relapsing-progressive MS, including the opticospinal form of MS, 18 of whom were seropositive for anti-AQP4 antibody. More patients with anti-AQP4 antibody showed a lack of the P100 component on visual-evoked potentials (VEPs) than those without the antibody (11/17, 64.7% vs. 20/84, 23.8%, p = 0.003), whereas the frequency of delayed P100 latency was significantly higher in the latter group than in the former (1/17, 5.9% vs. 28/84, 33.3%, p = 0.021). The frequencies of non-responses and delayed central sensory conduction times in median and posterior tibial nerve somatosensory-evoked potentials (SEPs) were not significantly different between anti-AQP4 antibody-positive and -negative patients. In terms of upper and lower limb motor-evoked potentials (MEPs), the frequencies of non-responses and delayed central motor conduction times did not differ significantly based on the presence or absence of anti-AQP4 antibody. The frequency of optic nerve lesions on MRI was significantly higher in anti-AQP4 antibody-positive patients than in anti-AQP4 antibody-negative patients (p=0.0137). Multiple logistic analyses revealed that anti-AQP4 antibody positivity (OR=8.406, p=0.02) and unevoked VEP responses (OR=35.432, p |
| 125. |
Katsuya Ogata, Tsuyoshi Okamoto, Takao Yamasaki, Hiroshi Shigeto, Shozo Tobimatsu, Pre-movement gating of somatosensory-evoked potentials by self-initiated movements: The effects of ageing and its implication, CLINICAL NEUROPHYSIOLOGY, 10.1016/j.clinph.2009.01.020, 120, 6, 1143-1148, 2009 Jun;120(6):1143-8. Epub 2009 May 10., 2009.06, Objective: To study whether the gating effect of the self-initiated movements on the cortical somatosensory-evoked potentials (SEPs) is affected by ageing.
Methods: The SEPs elicited by stimulating the right median nerve were recorded in 14 young and 16 older healthy Subjects, while self-initiated movements of the right fingers were performed at 5-10 s intervals. The amplitudes of the major components of the SEPs at F3 and C3' (2 cm posterior to 0) during the pre-movement period were analysed as the resting condition subserving the baseline.
Results: The amplitudes at rest were significantly greater in the elderly than in the Younger subjects. The amplitudes of P27, N35 and P45 at C3' as well as N30 at F3 decreased significantly during the pre-movement period. However, the ratio of amplitudes in the pre-movement period to the resting period in the elderly was not significantly different from that in the younger subjects, except for the interaction of N30.
Conclusions: The effect of age on the gating of N30 at F3 may indicate an altered preparatory processing of self-initiated movement in the elderly. The gating effect of older subjects at C3' is almost comparable to that of young ones, which appears to be a compensatory mechanism to maintain the precise movements.
Significance: Ageing affects the SEPs differently at rest and pre-movement gating. (C) 2009 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.. |
| 126. |
Hagiwara K, Ochi H, Suzuki S, Shimizu Y, Tokuda T, Murai H, Shigeto H, Ohyagi Y, Iwata M, Iwaki T, Kira JI., Highly selective leptomeningeal amyloidosis with transthyretin variant Ala25Thr., Neurology. 2009, Apr 14;72(15):1358-60, 2009.04. |
| 127. |
酒田 あゆみ, 森岡 隆人, 重藤 寛史, 吉良 龍太郎, 大塩 麻夕, 藤本 明子, 栢森 裕三, 康 東天, 話題の医療 脳波デジタルファイリングシステム ビデオ脳波モニタリングシステムの構築 てんかん診療において, 医療と検査機器・試薬, 32, 2, 175-181, 2009.04. |
| 128. |
重藤 寛史, 脳波検査技師と診療従事者で支えるてんかんのビデオ脳波モニタリング検査, 臨床脳波 51, 51, 3, 185-192, 2009.03, 脳波および同時記録ビデオのデジタル化に伴い、発作の起始や伝播、臨床発作との関連、頭蓋内と頭皮上脳波の相違などについて詳細に短時間に確認することが可能になった。当施設ではこれら脳波技師側からの情報と医師側からの臨床情報をお互いが授受する連携体制を構築し、モニター開始後一両日中に多くの情報を共有することができるようになった。今後もモニター時間短縮など患者さんの負担減少に貢献できるような運用をめざしている。(著者抄録). |
| 129. |
Kei-ichiro Takase, Hiroshi Shigeto, Satoshi O. Suzuki, Hitoshi Kikuchi, Yasumasa Ohyagi, Jun-ichi Kira, Cortical kindling in a focal freeze lesion rat model, JOURNAL OF CLINICAL NEUROSCIENCE, 10.1016/j.jocn.2008.04.007, 16, 1, 94-98, 2009 Jan;16(1):94-8. Epub 2008 Nov 18.
, 2009.01, Focal cortical dysplasia (FCD) is of increasing interest as a cause of focal epilepsy. We aimed to determine whether the existence of FCD influences the epileptogenicity induced by electrical kindling stimulation of the cortices. We created an FCD rat model by focal contact of a frozen metal probe on the scalp immediately after birth. To produce afterdischarges (ADs), electrical stimulation was applied to the frontal cortices once daily for 20 consecutive days from postnatal day 38 (P38). Thresholds and durations of ADs were measured. Brains were exposed and examined histologically at P58. We observed mild FCD, which consisted of disorganized cortices with extra sulci: however, there was no statistical difference in the thresholds or durations of ADs between FCD rats and control animals. These results suggest that FCD might not influence vulnerability to epileptogenicity, at least in some patients with fluid FCD. (c) 2008 Elsevier Ltd. All rights reserved.. |
| 130. |
Toshihiro Hokonohara, Hiroshi Shigeto, Yuji Kawano, Yasumasa Ohyagi, Michiya Uehara, Jun-ichi Kira, Facial onset sensory and motor neuronopathy (FOSMN) syndrome responding to immunotherapies, JOURNAL OF THE NEUROLOGICAL SCIENCES, 10.1016/j.jns.2008.07.021, 275, 1-2, 157-158, 2008 Dec 15;275(1-2):157-8. , 2008.12, We report the first non-Caucasian case of facial onset sensory and motor neuronopathy (FOSMN) syndrome partially responding to various immunotherapies. A 55-year-old man had first felt paresthesia on his right cheek at age 45. This gradually extended to the scalp. Paresthesia of bilateral fingers and dysphagia appeared 6 years later. On admission, facial sensory impairment and bulbar palsy were found. There were no sensory or motor deficits evident in any limb, except for decreased deep tendon reflex and vibratory sensation. Videofluorography (VF) revealed decreased pharyngeal clearance. The sensory nerve action potential (SNAP) amplitudes of median and ulnar nerves were decreased. Intravenous immunoglobulin therapy and plasma exchange ameliorated his dysesthesia and dysphagia after several weeks, and resulted in improvements in VF and SNAP abnormalities. These observations suggest that FOSMN syndrome maybe, in part, immune-mediated. (C) 2008 Elsevier B.V. All rights reserved.. |
| 131. |
金森祐治, 重藤寛史, 酒田あゆみ, 吉良潤一, 飛松省三, 1)パーキンソン病にて認められたSREDA類似所見, 臨床神経生理学, 36, 5, 2008.11. |
| 132. |
Hirokazu Furuya, Shigeto Hiroshi, Yasumasa Ohyagi, Naoki Fukumaki, Yasuyuki Fukumaki, Jun-ichi Kira, Unverricht-Lundborg disease with shorter expansion of dodecamer repeats diagnosed by RT-PCR, ANNALS OF NEUROLOGY, 64, S21-S21, 2008.11. |
| 133. |
重藤 寛史, てんかんの分類, Clinical neuroscience 24, 26, 1, 29-32, 2008.11. |
| 134. |
吉良潤一, 重藤寛史, 山崎貴男, 飛松省三, スモンに関する調査研究班 運動視刺激による視機能評価:2.スモン患者での検討, スモンに関する調査研究班 平成19年度総括・分担研究報告書, 2008.11. |
| 135. |
越智博文, 渡邉暁博, 松下拓也, 松岡健, 重藤寛史, 飛松省三, 吉良潤一, 免疫性神経疾患に関する調査研究 抗AQP4抗体日本人多発性硬化症(MS)患者における抗AQP4抗体(AQP4)と誘発電位(EP)の関連, 免疫性神経疾患に関する調査研究 平成19年度 総括・分担研究報告書, 2008.11. |
| 136. |
重藤寛史, 吉良潤一, 大八木保政, 熱媒体の人体影響とその治療法に関する研究 油症患者にみられる末梢神経障害の再検討, 熱媒体の人体影響とその治療法に関する研究 平成19年度 総括・分担研究報告書, 2008.11. |
| 137. |
古谷博和, 藤井直樹, 重藤寛史, 吉良潤一, 服巻保幸, 短いリピート延長を有するUnverricht-Lundborg病(ULD,EPM1)のCSTB遺伝子発現とメチル化の検討, 生化学, 2008.11. |
| 138. |
古谷博和, 重藤寛史, 藤井直樹, 吉良潤一, 短いリピート延長を有するUnverricht-Lundborg病(ULD)のCSTB遺伝子発現, 日本神経学会総会プログラム・抄録集, 49th, 2008.11. |
| 139. |
重藤寛史, 高瀬敬一郎, 吉良潤一, 脳波,脳MRIに異常が認められないてんかん症例の検討, 臨床脳波, 50, 7, 444-447, 2008.10, 当科てんかん外来を初診した86例中、複数回の全身痙攣発作を生じても脳波・脳MRIで異常がなく、てんかん診断に苦慮した4症例を検討した。2例で前兆としてあるいは前兆と関係なく既視感、記憶追想が存在し、うち1例で側頭葉内側のベンゾジアゼピン受容体の低下を認めた。他の1例で不安発作が存在した。4症例とも抗てんかん薬の投与で発作が消失・減少した。これらの症例では既視感、記憶追想、不安発作の有無の問診、脳MRI以外の画像検査の追加、抗てんかん薬の効果をみることが重要と考えられた。(著者抄録). |
| 140. |
Kei-ichiro Takase, Hiroshi Shigeto, Satoshi O. Suzuki, Hitoshi Kikuchi, Yasumasa Ohyagi, Jun-ichi Kira, Prenatal freeze lesioning produces epileptogenic focal cortical dysplasia, EPILEPSIA, 10.1111/j.1528-1167.2008.01558.x, 49, 6, 997-1010, Epilepsia. 2008 Mar 4
, 2008.06, Purpose: Focal cortical dysplasia (FCD) is thought to be an important cause of intractable epilepsy. However, its epileptogenicity remains unclear. Therefore, we created a novel rat model by freeze lesioning during the late embryonic stage to verify whether FCD influences seizure activities.
Methods: At 18 days postconception, a frozen probe was placed on the left scalp of a Sprague-Dawley rat embryo through the uterus wall. For 40 consecutive days from postnatal day 38 (P38), electrical kindling stimulation was applied to the frontal lobes of male rat pups. Afterdischarges (ADs) were measured in both the cortex and hippocampus. Brain tissues were examined by immunohistochemistry.
Results: All brains from prenatally freeze-lesioned rats displayed severe disorganization of the cortical layers with randomly oriented dendrites/axons. In addition, heterotopic cortices were observed in 42.1% of cases. ADs in the cortex and hippocampus were significantly prolonged in freeze-lesioned rats compared with those in sham-operated and control rats. FCD rats also revealed early development of hippocampal kindling and spontaneous cortico-hippocampal spikes, even in the chronic EEG recordings. Immunoreactivities for N-methyl-D-aspartate receptor (NMDAR) subunit 2B and glutamate/aspartate transporter in the lesions were significantly enhanced compared with the nonlesioned side, even in the absence of electrical stimulation. After electrical stimulation, NMDAR1 and 2B were markedly upregulated not only in the FCD, but also in the hippocampus.
Conclusions: Prenatal freeze lesioning of the brain produces a severe neuronal migration disorder, closely mimicking human FCD. Our model suggests that FCD is associated with vulnerability to epilepsy, and may augment hippocampal epileptogenicity.. |
| 141. |
松瀬 大, 池添 浩二, 重藤 寛史, 村井 弘之, 大八木 保政, 吉良 潤一, 限局性結節性筋炎から好酸球性筋炎へ移行した１例, 臨床神経学, 10.5692/clinicalneurol.48.36, 48, 1, 36-42, 2008.06, 症例は72歳男性である．71歳時より両下肢筋に限局性の有痛性結節を形成し，結節の場所を変えて再発寛解をくりかえした．また四肢近位筋，頸筋にも軽度筋力低下をみとめた．血液生化学ではCKの上昇をみとめ，抗Jo-1抗体も陽性であったが，末梢血中の好酸球増多はみとめなかった．当初は臨床的に限局性結節性筋炎と診断したが，その後の筋生検では好酸球の著明な浸潤をみとめ，好酸球性筋炎と診断した．このような限局性結節性筋炎類似の好酸球性筋炎の症例はきわめてまれである．本症例は，一部の好酸球性筋炎が限局性結節性筋炎，多発筋炎と類似の病態をもつ可能性を示唆する症例である．炎症性筋疾患における好酸球の意義を考えるうえで，貴重な症例であると思われた．
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| 142. |
Hagiwara Koichi, Murai Hiroyuki, Ochi Hirofumi, Osoegawa Manabu, Shigeto Hiroshi, Ohyagi Yasumasa, Kira Jun-ichi, Upper Motor Neuron Syndrome Associated with Subclinical Sjoegren's Syndrome, Internal Medicine, 10.2169/internalmedicine.47.0846, 47, 11, 1047-1051, 2008;47(11):1047-51. Epub 2008 Jun 2., 2008.06, We present two patients with primary lateral sclerosis-like upper motor neuron disease accompanying subclinical Sjögren's syndrome. Both patients showed progressive spastic quadriparesis, but neither sensory involvement nor detrusor dysfunction was noted. Lower motor neuron signs were detected only in their late follow-up period. Although sicca symptom was nearly absent, salivary labial gland biopsy revealed marked sialoadenitis in both patients. They also displayed a constellation of findings that suggested an autoimmune etiology closely related to Sjögren's syndrome, including germinal center formation in one patient, and markedly elevated levels of anti-nuclear antibody with abnormal sialography in the other. Both patients showed significant neurological improvement after the initial course of intravenous immunoglobulin therapy. We suggest that the evidence for subclinical Sjögren's syndrome should be sought in patients presenting with selective upper motor neuron involvement.
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| 143. |
萩原 綱一, 越智 博文, 村井 弘之, 重藤 寛史, 大八木 保政, 吉良 潤一, 潰瘍性大腸炎の経過中に脊髄炎を発症した1例, 日本内科学会雑誌, 10.2169/naika.96.1703, 96, 8, 1703-5, 2007.08, 症例は潰瘍性大腸炎で治療中の54歳女性．最近5年間は再燃なく安定していたが，約2週間の経過で体幹を含む両下肢の感覚障害と痙性歩行を来した．髄液所見は正常．脊髄MRIでTh6-7の右後索∼側索にT2延長域を認めた．潰瘍性大腸炎に関連した脊髄炎と診断し，ステロイドパルス療法を施行．症状及び画像所見の改善をみた．潰瘍性大腸炎において脊髄炎を合併することは極めて稀であり，画像的に病変が証明された貴重な一例である．
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| 144. |
Takayuki Taniwaki, Akira Okayama, Takashi Yoshiura, Osamu Togao, Yasuhiko Nakamura,Array, Katsuya Ogata, Hiroshi Shigeto, Yasumasa Ohyagi, Jun-ichi Kira, Shozo Tobimatsu, Age-related alterations of the functional interactions within the basal ganglia and cerebellar motor loops in vivo., NeuroImage, 10.1016/j.neuroimage.2007.04.027, 36, 4, 1263-1276, 2007.07, Taniwaki T, Okayama A, Yoshiura T, Togao O, Nakamura Y, Yamasaki T, Ogata K, Shigeto H, Ohyagi Y, Kira J, Tobimatsu S, NeuroImage, 2007, vol. 36, no. 4, pp. 1263-1276, 2007. |
| 145. |
Mami Fukunaga, Yasumasa Ohyagi, Mitsuya Morita, Hiroshi Shigeto, Takayuki Taniwaki, Jun-ichi Kira, [Late-onset sporadic case of SPG4 (1726T>C mutant) accompanied by polyneuropathy with diabetes mellitus]., Rinsho shinkeigaku = Clinical neurology, 47, 6, 359-61, 2007.06, We report a 73-year-old man with SPG4. From aged 53 he had diabetes mellitus and at 64 he developed spastic paraparesis and urinary disturbance. At 70 years, he began to walk with a stick and noted abnormal sensations in bilateral feet. There was no relevant family history. Moderate spasticity with mild muscle weakness, markedly brisk tendon reflex with pathological reflexes, and mildly abnormal sensation in bilateral lower extremities, and markedly spastic gait were found. MRI showed mild C4-C7 spondylosis and L4-5 disk protrusion but no abnormality of the corpus callosum. Nerve conduction and needle EMG studies revealed various abnormalities in distal (MCV, SCV) and proximal (F-wave) peripheral nerves, but no neurogenic changes in limb muscles. We found a missense spastin gene mutation (1726T>C) that causes Leu534Pro substitution. This spastin gene mutation was novel in Japanese, but has been reported in an Italian family. The present case's neuropathy might be related to diabetes mellitus, because SPG4 is generally not associated with neuropathy. However, recent studies suggest that SPG4 patients sometimes have subclinical neuropathy, and longer disease duration may contribute to peripheral neuropathy. Further study of clinical characteristics associated with the Leu534Pro mutation will be necessary.. |
| 146. |
Arnold Angelo M. Pineda, Katsuya Ogata, Manabu Osoegawa, Hiroyuki Murai, Hiroshi Shigeto, Takashi Yoshiura, Shozo Tobimatsu, Jun-ichi Kira, A distinct subgroup of chronic inflammatory demyelinating polyneuropathy with CNS demyelination and a favorable response to immunotherapy, JOURNAL OF THE NEUROLOGICAL SCIENCES, 10.1016/j.jns.2007.01.004, 255, 1-2, 1-6, 15;255(1-2):1-6.
, 2007.04, To explore subclinical central nervous system (CNS) involvement in chronic inflammatory demyelinating polyneuropathy (CIDP), we recorded somatosensory evoked potentials (SEPs) and motor evoked potentials (MEPs) using transcranial magnetic stimulation, to measure central sensory conduction time (CSCT) and central motor conduction time (CMCT) and examined brain and spinal cord MRI in patients with probable CIDP based on the American Academy of Neurology AIDS Task Force criteria. Eighteen patients with probable CIDP (12 males and 6 females; mean age at examination +/- SD, 45.8 +/- 17.0 years; range, 17-72) were included in the study. Of the 13 patients who underwent SEPs, one had prolonged CSCT (8%) and of the 13 who underwent MEPs, four had abnormal CMCT (31%). Cranial MRI revealed five of 18 patients had abnormal scans, only one of which showed multiple ovoid periventricular lesions suggestive of demyelination while none showed any intramedullary lesion on spinal cord MRI. Thus, 6 of the 18 patients were considered to have subclinical demyelinative CNS involvement which had lower disability on Global Neurological Disability Score (GNDS) (p=0.0061), a male preponderance (0.0537) and a larger compound muscle action potential (CMAP) amplitude in the median nerve (p=0.005) than those without. The decrease of GNDS with immunologic therapies was nearly significant in the former (p=0.0556) but not in the latter. The results of the present study suggest that subclinical CNS involvement in CIDP is not uncommon in Japanese patients and that CIDP with subclinical CNS involvement is more demyelinative thus responsive to immunotherapies while those without have more axonal damage and less responsive to immunotherapies. (c) 2007 Elsevier B.V. All rights reserved.. |
| 147. |
Christoph Kellinghaus, Gabriel Möddel, Hiroshi Shigeto, Zhong Ying, Berit Jacobsson, Jorge Gonzalez-Martinez, Candice Burrier, Damir Janigro, Imad M Najm, Dissociation between in vitro and in vivo epileptogenicity in a rat model of cortical dysplasia., Epileptic disorders : international epilepsy journal with videotape, 9, 1, 11-9, 9(1):11-9.
, 2007.03, OBJECTIVE: Malformations of cortical development are frequent causes of human refractory epilepsy. The freeze-lesion model in rats shows histopathological features similar to those found in human polymicrogyria. Previous studies reported in vitro hyperexcitability in this model, but in vivo epileptogenicity has not been confirmed. METHODS: Neocortical freeze lesions were induced in Sprague-Dawley rat pups (n = 10) on postnatal day 0 or 1 (P0/P1). Sham-operated animals served as controls (n = 10). On P60, animals were implanted with epidural electrodes for long-term video-EEG monitoring (4 weeks). The threshold for pentylenetetrazol-induced seizures was determined. Animals were sacrificed and brain sections processed for histological staining and in vitro electrophysiological recordings. Epileptiform field potential repetition rate, amplitude and integral were compared between slices containing a cortical freeze lesion, and slices from sham-operated rats. RESULTS: No interictal spikes and no electrographic or clinical seizures occurred in either group. The median threshold for pentylenetetrazol-induced seizures was 60 mg/kg for lesioned, and 45 mg/kg for control animals (difference not significant). No spontaneous epileptiform field potentials were recorded from either freeze-lesion or control slices bathed in normal, artificial cerebrospinal fluid (ACSF). Upon omission of Mg(2+) from the bath, epileptiform field potentials were elicited that showed a significantly higher burst integral in the freeze lesion slices compared to control slices. CONCLUSION: Neocortical freeze lesions induced in newborn rat pups show histological characteristics reminiscent of human cortical dysplasia. Brain slices containing neocortical freeze lesions display hyperexcitability in vitro, but the same lesion does not appear to show spontaneous epileptogenicity in vivo.. |
| 148. |
H. Doi, H. Kikuchi, H. Murai, Y. Kawano, H. Shigeto, Y. Ohyagi, J. Kira, Motor neuron disorder simulating ALS induced by chronic inhalation of pyrethroid insecticides, Neurology, 10.1212/01.wnl.0000244489.65670.9f, 67, 10, 1894-1895, 2006.11. |
| 149. |
副島直子, 大八木保政, 菊池仁志, 村井弘之, 重藤寛史, 吉良潤一, 静止時振戦を呈したBassen-Kornzweig症候群成人うたがい例, 臨床神経学, 46, 10, 702-6, 2006.10. |
| 150. |
Takayuki Taniwaki, Akira Okayama, Takashi Yoshiura, Osamu Togao, Yasuhiko Nakamura, Takao Yamasaki, Katsuya Ogata, Hiroshi Shigeto, Yasumasa Ohyagi, Jun-ichi Kira, Shozo Tobimatsu, Functional network of the basal ganglia and cerebellar motor loops in vivo: Different activation patterns between self-initiated and externally triggered movements, NEUROIMAGE, 10.1016/j.neuroimage.2005.12.032, 31, 2, 745-753, 31:745-753, 2006.06, Taniwaki T, Okayama A, Yoshiura T, Togao O, Nakamura Y, Yamasaki T, Ogata K, Shigeto H, Ohyagi Y, Kira J, Tobimatsu S, NeuroImage, 2006, vol. 31, no. 2, pp. 745-753, 2006. |
| 151. |
大島幸子, 重藤寛史, 川尻真和, 谷脇考恭, 吉浦敬, 吉良潤一, 頸動脈海綿静脈洞瘻を有し静脈性脳梗塞を生じた1例, 臨床神経学, 46, 4, 261-5, 2006.04. |
| 152. |
金 青玉, 谷脇 考恭, 重藤 寛史, 野村 拓夫, 大八木 保政, 症例報告 精神症状を伴った成人発症のシデナム舞踏病の1例, Brain and Nerve 脳と神経, 10.11477/mf.1406100134, 58, 2, 155-9, 2006.02, 56歳男.バス運転手であった患者は著者らの施設へ入院前,危険運転や対人関係にトラブルをおこし,発熱も生じるといったエピソードがあった.その後,落ち着きがない,手足が勝手に動くといった主訴が出現し,左肩関節痛を自覚した.やがて,会話が通じないほどの精神症状が出現し,今回,入院となった.入院時,痴呆,感情失禁,異常行動,左肢優位の舞踏病様不随意運動を認めた.頭部MRIでは右優位の尾状核頭の腫脹を認め,脳18F-deoxyglucose-positron emission tomographyでは右線条体,特に右尾状核に集積亢進が認められた.左優位の舞踏病様運動によく合致し,その原因として炎症が考えられた.更にガリウムシンチでは四肢の関節部の集積が亢進しており,関節炎の可能性が示唆された.治療として,異常行動にhaloperidol投与を行なった結果,症状は落ち着き,舞踏病も徐々に減少していった.以上,本症例は関節痛,舞踏病,発熱,血沈亢進,CRP上昇を認めたことから,シデナム舞踏病と考えられた.シデナム舞踏病の20歳以上発症は稀で8%以下であり,精神症状を伴った成人発症例は本症例が初の報告であった. |
| 153. |
田代研之, 重藤寛史, 田中正人, 川尻真和, 谷脇考恭, 吉良潤一, 多発性脳梗塞を呈した若年女性の脳底動脈fibromuscular dysplasiaの1例, 臨床神経学, 46, 1, 35-9, 2006.01. |
| 154. |
H Shigeto, T Uehara, K Uchida, T Nomura, T Taniwaki, J Kira, Thalamic involvement of status epilepticus: diffusion-weighted image of MRI in two cases of status epilepticus, UNVEILING THE MYSTERY OF THE BRAIN: NEUROPHYSIOLOGICAL INVESTIGATION OF THE BRAIN FUNCTION, 10.1016/j.ics.2004.11.075, 1278, 193-196, 2005.11, Status epilepticus (SE) is prolonged and repetitive epileptic seizure. SE is associated with widespread neuronal necrosis in vulnerable regions of the brain. We obtained diffusion-weighted image of magnetic resonance imaging (DWI-MRI) from two cases with SE. Case I is a 55-year-old man who showed repetitive tonic seizures on his left side evolving to generalized tonic seizure. Seizure occurred every 20 min at maximum rate. Todd's palsy was seen on his left side. Electroencephalogram (EEG) showed repetitive high-amplitude sharp waves over the right front-central region, which continued 10 days with diminishing repetitive rate of sharp waves. DWI-MRI showed high signal intensity at the right frontal cortex and dorsomedial portion of the thalamus. Apparent diffusion coefficient (ADC) was low at the same area. Case 2 is a 37-year-old woman. She initially stopped speech evolving to generalized tonic seizure. The seizure disappeared 30 min later. Todd's palsy appeared on her right side. EEG showed repetitive spikes, polyspikes and slow waves with high amplitude over the left centro-parieto-tempolo-occipital region, which disappeared next day. DWI-MRI showed high signal intensity at the left parieto-tempolo-occipital lobes without the thalamic involvement. ADC was low at the same area. Thalamus was involved in case 1, but not in case 2. The fact may depend on the intensity of epileptic activity of neocortex. (c) 2004 Elsevier B.V. All rights reserved.. |
| 155. |
有村 公一, 村井 弘之, 菊池 仁志, 重藤 寛史, 谷脇 考恭, 古谷 博和, 吉良 潤一, 胃切除後に再発を繰り返したＷｅｒｎｉｃｋｅ脳症の１例, 日本内科学会雑誌, 10.2169/naika.94.1606, 94, 8, 1606-8, 2005.08, 症例は45歳男性. 42歳時に噴門側部分胃切除を施行.術後,眼球運動障害と四肢脱力,体幹失調を2回繰り返した.頭部MRIで両側視床および中脳水道周囲に異常信号域を認め,血中ビタミンB1が著明に低下していた.入院当日よりビタミンB1を投与開始したところ2日目には眼球運動障害は消失, 2週間後には歩行可能となった.大酒家でなくても胃切除の既往を有する例では少量のアルコール摂取でも繰り返しWernicke脳症を起こす可能性が考えられた.. |
| 156. |
Hiroshi Shigeto, Taira Uehara, Kazuki Uchida, Takuo Nomura, Takayuki Taniwaki, Jun-ichi Kira, Thalamic involvement of status epilepticus: diffusion-weighted image of MRI in two cases of status epilepticus, International congress series, 1278, 193-196, 2005.01. |
| 157. |
Yuko Tsuruta, Koji Ikezoe, Hideaki Nakagaki, Hiroshi Shigeto, Masakazu Kawajiri, Yasumasa Ohyagi, Jun-Ichi Kira, A case of dermato-fasciitis: amyopathic dermatomyositis associated with fasciitis., Clinical rheumatology, 23, 2, 160-2, 2004.04, Amyopathic dermatomyositis (ADM) is characterized by the typical cutaneous features of dermatomyositis and minor involvement of the skeletal muscles. A 50-year-old woman had fever, reddening and pain in the distal part of all four limbs, and cutaneous findings such as Gottron's papules and periorbital heliotrope. She showed no muscle weakness or atrophy, and her serum creatine kinase was within the normal range. Electromyography showed no myopathic pattern. Magnetic resonance imaging (MRI) recorded abnormal hyperintensity in the fascia and muscle of the tibialis anterior. A biopsy from the tibialis anterior muscle showed fasciitis and mild myopathic changes with focal perivascular infiltration. This patient also presented with interstitial pneumonitis, although evaluation for malignancy was negative. With steroid therapy, her symptoms and MRI abnormality disappeared within 2 months. This case is therefore considered to be a variant of ADM, presenting as dermato-fasciitis.. |
| 158. |
山崎亮, 大八木保政, 川尻真和, 重藤寛史, 池添浩二, 古谷博和, 吉良潤一, 女性化乳房およびエストリオール増加を呈したミトコンドリア脳筋症の1例, 臨床神経学, 44, 4-5, 291-295, 2004.04. |
| 159. |
徳永 秀明, 重藤 寛史, 稲村 孝紀, 中脳水道狭窄症,脳室内腹腔シャント不全により高度のパーキンソニズムを呈した1例—A case of severe parkinsonism induced by failure of ventriculo-peritoneal shunt for aqueductal stenosis, 臨床神経学 = Clinical neurology / 日本神経学会 編, 43, 7, 427-30, 2003.07. |
| 160. |
重藤 寛史, 田村 拓久, 大矢 寧, 洞機能異常をみとめた顔面肩甲上腕型筋ジストロフィーの1例—Facioscapulohumeral muscular dystrophy with sinus dysfunction, 臨床神経学 = Clinical neurology / 日本神経学会 編, 42, 9, 881-4, 2002.09. |
| 161. |
丸山 健二, 大矢 寧, 重藤 寛史, 小川 雅文, 川井 充, 症例報告 椎骨脳底動脈･後大脳動脈領域に限局した若年性多発脳梗塞の1例, Brain and Nerve 脳と神経, 10.11477/mf.1406901888, 54, 1, 29-33, 2002.01, 37歳男.16歳より幻聴,妄想が出現し,精神分裂病として入院していた.36歳時,CTで両側視床,右小脳半球に低吸収域を認めた.37歳時,右口角より流涎,右麻痺が出現したが自然に消失した.その2ヵ月後複視を訴え受診,左眼内転障害を認め,CTで新たに橋上部左腹側の低吸収域を認めた.その3ヵ月後嚥下障害,右麻痺出現,脳MRIで右小脳半球,両側視床,橋上部左腹側にT2強調像で高信号域を認め,MRAで椎骨脳底動脈(VBA)が細く,両側後大脳動脈(PCA)は描出されなかった.血管造影検査ではVBAが細く両PCAの狭窄,壁不整が認められ,PCA領域には中大脳動脈からの側副血行がみられた.SPECTでは両側前頭葉,側頭葉,両側視床,右小脳半球,脳幹部に集積低下を認めた.内服療法で症状改善したが,翌年右麻痺と発声障害で別医に入院した.VBA-PCA系の先天性低形成と,何らかの後天性狭窄が原因と考えられた. |
| 162. |
山本敏之, 重藤寛史, 吉田統子, 小沢律子, 大石健一, 大矢寧, 小川雅文, 松岡正明, 川井充, Bender Gestalt testでとらえられる進行性核上性麻ひの臨床的異常 (厚生労働省S), 神経変性疾患に関する研究班 2000年度研究報告書, 2001.11. |
| 163. |
Kenji Maruyama, Yasushi Oya, Hiroshi Shigeto, Masafumi Ogawa, Mitsuru Kawai, Spontaneous improvement of subacute exacerbation in a case of sensory ataxic neuropathy associated with Sjögren's syndrome, Clinical Neurology, 41, 9, 617-620, 2001.11, We reported a 66-year-old man with Sjögren's syndrome (sicca syndrome) presenting a sensory ataxic neuropathy, which showed spontaneous remission. He developed difficulty in standing and walking during recent several months. Neurological examinations showed sensory ataxia with areflexia in all extremities and mild distal-dominant decrease in the superficial sensation. Laboratory examinations of blood, urine, and cerebrospinal fluid were all unremarkable; the blood levels of vitamin B1, B2, B6 and B12 were low normal. Sensory nerve action potentials and somatosensory evoked potentials were absent. Cervical cord MRI revealed no abnormal signals. Severe loss of myelinated fibers and scattered myelin ovoids were seen in sural nerve biopsy. Tentative diagnosis at admission was subacute sensory neuropathy associated with malignancy. Screening examinations for malignancy were undertaken and all revealed negative. Because of coexisting sicca symptoms and positive Shirmer test (0 mm), a lip biopsy was performed and a diagnosis of Sjögren's syndrome was confirmed. Sensory ataxia improved gradually. Two years later, blood B1 levels were low but he remained able to walk. This case is an uncommon example of spontaneous symptomatic remission in sensory ataxic neuropathy associated with Sjögren's syndrome.. |
| 164. |
川井充, 小沢律子, 大石健一, 山本敏之, 重藤寛史, 大矢寧, 小川雅文, パーキンソン病QOL評価スケールPDQ-39実施経験 (厚生労働省S), 神経変性疾患に関する研究班 2000年度研究報告書, 2001.11. |
| 165. |
川井充, 大矢寧, 重藤寛史, 小川雅文, 日本ではパーキンソン病は女性に多いか (厚生労働省S), 神経変性疾患に関する研究班 2000年度研究報告書, 2001.11. |
| 166. |
小川雅文, 丸山健二, 大矢寧, 重藤寛史, 松田博史, 吉岡雅之, 大石健一, 山本敏之, 川井充, パーキンソン病患者の123I-MIBG心筋シンチグラフィーの検討 (厚生省S), 神経変性疾患に関する研究班 1999年度研究報告書, 2000.11. |
| 167. |
川井充, 重藤寛史, 大石健一, 吉岡雅之, 山本敏之, 丸山健二, 大矢寧, 小川雅文, パーキンソン病に対するアポモルフィン試験の臨床応用 (厚生省S), 神経変性疾患に関する研究班 1999年度研究報告書, 2000.11. |
| 168. |
川井充, 大石健一, 小川雅文, 重藤寛史, 丸山健二, 吉岡雅之, 山本敏之, 松田博史, 大西隆, パーキンソン病と高次神経機能 算数問題と脳血流SPECT所見 (厚生省S), 神経変性疾患に関する研究班 1999年度研究報告書, 2000.11. |
| 169. |
H. Kikuchi, T. Yamada, A. Okayama, H. Hara, T. Taniwaki, H. Shigeto, M. Sasaki, T. Iwaki, J. Kira, Anti-Ri-associated paraneoplastic cerebellar degeneration without opsoclonus in a patient with a neuroendocrine carcinoma of the stomach., Fukuoka igaku zasshi = Hukuoka acta medica, 91, 4, 104-109, 2000.04, We report a case of a 63-year-old man suffering from anti-Ri-associated paraneoplastic cerebellar degeneration (PCD) with gastric cancer. The neurologic presentation was limited to severe cerebellar ataxia without opsoclonus. The gastric cancer was composed of both poorly differentiated adenocarcinoma and neuro-endocrine carcinoma. The patient's serum reacted with recombinant Ri antigen and the neuroendocrine tumor component. It is thus considered that PCD without opsoclonus in the present case was related to the gastric neuroendocrine tumor and anti-Ri antibody.. |
| 170. |
森岡隆人, 重藤寛史, 西尾俊嗣, 久田圭, 福井仁士, てんかん外科における脳磁図の有用性と限界 (てんかん治療研究振興財団S), てんかん治療研究振興財団研究年報, 11, 1999.11. |
| 171. |
SHIGETO Hiroshi, Visual evoked cortical magnetic responses to checkerboard pattern reversal stimulation : a study on the neural generators of N75, P100 and N145, J Neurol Sci, 10.1016/S0022-510X(98)00026-4, 156, 186-194, 156(2):186-94, 1998.11. |
| 172. |
Takayuki Taniwaki, Takeshi Yamada, Tsuyoshi Yoshida, Masayuki Sasaki, Yasuo Kuwabara, Makoto Nakagawa, Futoshi Mihara, Satoru Motomura, Hiroshi Shigetou, Jun Ichi Kira, Heterogeneity of glucose metabolism in corticobasal degeneration, Journal of the Neurological Sciences, 10.1016/S0022-510X(98)00269-X, 161, 1, 70-76, 1998.11, A positron emission tomography (PET) study on the regional cerebral glucose metabolism (rCMRglc) was performed in six patients with corticobasal degeneration (CBD). The clinical features included asymmetrical parkinsonism with apraxia, were related to the cerebral cortical and basal ganglionic dysfunction. An MRI study showed all cases to have asymmetrical atrophy in the front-parietal cortex contralateral to the dominantly affected limb; however, no case was pathologically verified. A PET study revealed three cases to have asymmetrical glucose hypometabolism in the parietal lobe and thalamus, which was compatible with the results of previous reports. However, two patients demonstrated symmetrical glucose hypometabolism in the frontal lobe, striatum and parietal lobe while one case had a diffuse hypometabolism, in spite of a marked asymmetry of the neurological findings. These results therefore suggest the heterogeneity of the glucose hypometabolism in CBD based on the PET findings.. |
| 173. |
吉良潤一, 重藤寛史, 菅理恵, 飛松省三, 加藤元博, スモンにおける磁気刺激による運動誘発電位 IV.後期ヒラメ筋反応の解析 (厚生省S), スモン調査研究班 平成9年度研究報告書, 1998.11. |
| 174. |
石橋秀昭, 森岡隆人, 西尾俊嗣, 村石光輝, 村上信哉, 重藤寛史, 楢崎修, 福井仁士, 脳波・筋電図の臨床 中頭蓋かクモ膜嚢胞のepileptogenicityについて, 臨床脳波, 39, 12, 1997.11. |
| 175. |
Hiroshi Shigeto, Shozo Tobimatsu, Takato Morioka, Tomoya Yamamoto, Takuro Kobayashi, Motohiro Kato, Jerk-locked back averaging and dipole source localization of magnetoencephalographic transients in a patient with epilepsia partialis continua, Electroencephalography and Clinical Neurophysiology, 10.1016/S0013-4694(97)00040-0, 103, 4, 440-444, 1997.10, In order to localize the generator site of epilepfiform discharges, we applied the techniques of jerk-locked back averaging (JBA) of magnetoencephalographic (MEG) activities and dipole source localization in a patient with epilepsia partialis continua (EPC), who showed continuous, focal myoclonic jerks in the right arm. The myoclonic discharges in the right thenar muscle were used as a trigger pulse. JBA revealed consistent EEG and MEG transients that coincided consistently and constantly preceded the myoclonic jerks. The estimated dipoles of MEG were localized in a restricted area in the left precentral area, which closely correlated with the area of epileptic discharges recorded in electrocorticography. Therefore, JBA of MEG is considered to be a useful non-invasive method for localizing the epileptogenic area in EPC.. |
| 176. |
T. Morioka, T. Yamamoto, A. Mizushima, S. Tombimatsu, H. Shigeto, K. Hasuo, S. Nishio, K. Fujii, M. Fukui, Erratum: Comparison of magnetoencephalography, functional MRI, and motor evoked potentials in the localization of the sensory-motor cortex (Neurological Research (1995) 17 (361-367)), Neurological Research, 18, 2, 156, 1996.11. |
| 177. |
T. Morioka, S. Nishio, T. Yamamoto, H. Shigeto, T. Minami, I. Takeshita, K. Fujii, M. Fukui, Surgical management of epilepsy associated with cerebral neurocytoma, Epilepsia, 10.1111/j.1528-1157.1996.tb01834.x, 37, SUPPL. 3, 69-70, 1996.11. |
| 178. |
小林卓郎, 重藤寛史, 飛松省三, 加藤元博, 山本智矢, 有機水銀中毒症の臨床的研究 水俣病における非侵襲的脳機能検査法の開発 視覚誘発脳磁界の計測 (環境庁S), 有機水銀の健康影響に関する研究 平成7年度 重金属等の健康影響に関する総合研究班, 1996.11. |
| 179. |
T. Morioka, T. Yamamoto, A. Mizushima, S. Tombimatsu, H. Shigeto, K. Hasuo, S. Nishio, K. Fujii, M. Fukui, Comparison of magnetoencephalography, functional MRI, and motor evoked potentials in the localization of the sensory-motor cortex, Neurological Research, 10.1080/01616412.1995.11740343, 17, 5, 361-367, 1995.11, To clarify the topographical relationship between peri-Rolandic lesions and the central sulcus, we carried out presurgical functional mapping by using magnetoencephalography (MEG), functional magnetic resonance imaging (f- MRI), and motor evoked potentials (MEPs) on 5 patients. The sensory cortex was identified by somatosensory evoked magnetic fields using MEG (magnetic source imaging (MSI)). The motor area of the hand region was identified using f-MRI, during a hand squeezing task. In addition, transcranial magnetic stimulation localized the hand motor area on the scalp, which was mapped onto the MRI. In all cases, the sensory cortical vein or the lack of any functional activation in the area of peri-lesional edema. MEPs were also unable to localize the entire motor strip. Therefore, at present, MSI is considered to be the most reliable method to localize peri-Rolandic lesions. [Neurol Res 1995; 17: 361-367] cortical vein or the lack of any functional activation in the area of peri-lesional edema. MEPs were also unable to localize the entire motor strip. Therefore, at present, MSI is considered to be the most reliable method to localize peri-Rolandic lesions.. |
| 180. |
山本智矢, 南武嗣, 森岡隆人, 重藤寛史, SQUIDの臨床応用はどこまで可能か, 電気学会マグネティックス研究会資料, MAG-94, 34-43.45-52, 1994.11. |
| 181. |
森岡隆人, 西尾俊嗣, 福井仁士, 重藤寛史, 山本智矢, 高度先進医療 神経磁気計測装置の臨床応用, 看護技術, 40, 12, 1994.11. |
| 182. |
Shunji Nishio, Hiroshi Shigeto, Masashi Fukui, Hypothalamic hamartoma: the role of surgery, Neuro Surgical Review, 10.1007/BF00258250, 16, 2, 157-160, 1993.06, A hypothalamic hamartoma associated with true precocious puberty in a 7-month-old girl is hereby reported. Hormonal studies disclosed elevated serum levels of luteinizing hormone (LH) and follicle stimulating hormone, both of which responded well to LH-releasing hormone stimulation. Following a subtotal removal of the tumor, the clinical manifestations of precocious puberty as well as associated endocrinological abnormalities returned to normal. The role of surgery for this lesion, which appears to be safe when a planned microsurgical course is employed, is discussed. © 1993 Walter de Gruyter & Co.. |
| 183. |
重藤寛史, 山田猛, 小林卓郎, 後藤幾生, 下肢のけい縮および遠位部筋萎縮を呈したHyperornithinemia-hyperammonemia-homocitrullinuria(HHH)症候群の1例, 臨床神経学, 32, 7, 1992.11. |
| 184. |
重藤寛史, 下肢の痙縮および遠位部筋萎縮を呈したHHH症候群の1例, 臨神経, 32, 7, 729-732, 1992.11, 16歳男,両親はいとこ婚。幼少時より知能遅延および嘔吐がしばしばあったが,意識消失発作はなかった。15歳時より進行性の歩行障害をきたし,大腿四頭筋の高度の痙縮と下肢遠位筋に著明な筋萎縮と脱力を認め,筋電図および神経生検所見から筋萎縮の原因は脊髄前角細胞障害が考えられた。これら神経徴候の出現に高オルニチンのみならず高グルタミン酸などアミノ酸異常が関与している可能性が示唆された. |
