九州大学 研究者情報
発表一覧
松元 幸一郎(まつもと こういちろう) データ更新日:2021.05.20

准教授 /  医学研究院 附属胸部疾患研究施設 九州大学大学院医学研究院附属胸部疾患研究施設


学会発表等
1. 松元 幸一郎, 肺発育障害のCOPD発症に関わる因子:「肺発育障害と幼少期疾患」, 日本呼吸器学会, 2021.09.
2. 松元 幸一郎, 日本呼吸器学会と日本アレルギー学会の共同企画:喘息‐COPDオーバーラップ(ACO): COPDの立場から, 日本呼吸器学会, 2018.04.
3. 松元 幸一郎, Interleukin-22 downregulates double-stranded RNA-induced expression of B7-H1/PD-L1 on airway epithelial cells, 2014.09, Background and Aim: Airway viral infection is a cause of exacerbations of COPD. B7-H1/PD-L1 is a coinhibitory molecule implicated in an escape mechanism of viruses from the host immune systems. Molecules suppressing expression of B7-H1/PD-L1 may be preventive for virus-induced exacerbation. Interleukin-22 (IL-22) is a member of the IL-10 family that is produced from a variety of immune cells and has protective properties on tissue-structural cells including epithelial cells. We investigated the effect of IL-22 on the expression of B7-H1/PD-L1.
Methods: Airway epithelial cell lines were treated with or without an analog of viral double-stranded RNA, polyinosinic-polycytidylic acid (poly I:C) in the presence or absence of human IL-22. The expression of B7-H1/PD-L1 was assessed by flow cytometry.
Results: The expression of B7-H1/PD-L1 was upregulated by poly I:C in a dose-dependent manner. The magnitude of B7-H1/PD-L1 expression remained constant from 24h to 48h after the stimulation of poly I:C. Without poly I:C, the expression of B7-H1/PD-L1 was not affected by treatment with IL-22. Poly I:C-induced upregultaion of B7-H1/PD-L1 was significantly attenuated by treatment with IL-22.
Conclusion: IL-22 downregluates double-stranded RNA-induced expression of B7-H1/PD-L1 on airway epithelial cells, suggesting a beneficial role of IL-22 in virus-associated pathogenesis of COPD. The examinations for in vivo effect of IL-22 is underway using a murine model of poly I:C-induced inflammation.
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4. Koichiro Matsumoto, Keiko Kan-o, Miyuki Tsuda, Satoru Fukuyama, Yukari Asai, Takafumi Matsumoto, Atsushi Moriwaki, Yuko Matsunaga, Hiroko Kitajima, Taro Kawai, Osamu Takeuchi, Shizuo Akira, Hideo Yagita, Miyuki Azuma, Yoichi Nakanishi, Hiromasa Inoue, Essential role of B7-H1 in double-stranded RNA-induced augmentation of an asthma phenotype in mice., American Thoracic Society International Conference, 2011.05.
5. 松元 幸一郎,
喘息とCOPDのオーバーラップ症候群「オーバーラップ症候群について:治療を中心に」

(日本アレルギー学会との共同企画)
, 第54回日本呼吸器学会学術講演会 2014年4月25日、大阪, 2014.04.

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