Kyushu University Academic Staff Educational and Research Activities Database
List of Reports
Akira Shiose Last modified date:2021.08.20

Professor / Department of Cardiovascular Surgery, Faculty of Medical Sciences, Kyushu University / Research Institute of Angiocardiology / Faculty of Medical Sciences

1. Takuya Nishijima, Yoshihisa Tanoue, Tomoki Ushijima, Akira Shiose, A staged surgical strategy for cardiogenic shock and iatrogenic ventricular septal perforation due to a malpositioned catheter, General thoracic and cardiovascular surgery, 10.1007/s11748-020-01425-z, 2020, A 59-year-old woman fell into cardiogenic shock due to acute myocardial infarction with total occlusion of the left anterior descending artery. Although intra-aortic balloon pump was inserted and a coronary stent was placed, she went into cardiopulmonary arrest and percutaneous veno-arterial extracorporeal membrane oxygenation (ECMO) was initiated. She was transferred to our hospital after drainage for pericardial effusion. Computed tomography revealed the drainage catheter lying through the right ventricular free wall and the ventricular septum, and leading into the left ventricle. She showed multiple organ failure and disseminated intravascular coagulation syndrome due to insufficient ECMO flow. Conversion to central ECMO after catheter removal was performed and her general condition improved; however, ventricular septal shunt remained. Repair of the perforation and ECMO removal was performed 15 days after the first operation. The combination of optimal mechanical circulatory support and the staged surgical repair contributed to her dramatic recovery..
2. Shunji Hayashidani, Akira Shiose, Hiroyuki Tsutsui, New-onset left bundle branch block after transcatheter aortic valve implantation ― not a harmless bystander ―, Circulation Journal, 10.1253/circj.CJ-20-0292, 2020.
3. Seiji Takashio, Koichi Kaikita, Masato Nishi, Mami Morioka, Taiki Higo, Akira Shiose, Tsuyoshi Doman, Hisanori Horiuchi, Toshihiro Fukui, Kenichi Tsujita, Detection of acquired von Willebrand syndrome after ventricular assist device by total thrombus-formation analysis system, ESC Heart Failure, 10.1002/ehf2.12824, 2020, Aims: Bleeding is a serious complication in patients with continuous-flow left ventricular assist device (CF-LVAD). Acquired von Willebrand syndrome (AVWS; type 2A) develops because of high shear stress inside the pumps and is a cause of bleeding complication. Although von Willebrand factor (vWF) multimer analysis is useful for diagnosing AVWS, it is only performed in specialized research institutes. A novel microchip flow chamber system, the total thrombus-formation analysis system (T-TAS), is a point-of-care system to evaluate the thrombus-formation process and useful for monitoring platelet thrombus-formation capacity in patients receiving antiplatelet therapy and the diagnosis and evaluation of the clinical severity of von Willebrand disease type 1. However, little is known about the association between AVWS and platelet thrombus-formation capacity evaluated by T-TAS in patients with CF-LVAD. We aimed to evaluate the utility of T-TAS for easy detection of AVWS in patients with CF-LVAD. Methods and results: We simultaneously evaluated the vWF large multimers and T-TAS parameters in four consecutive patients with axial-type CF-LVAD and eight control patients treated with aspirin and warfarin. vWF large multimer index was defined as the proportion of large multimers in total vWF derived from a normal control plasma. T-TAS analyses different thrombus-formation processes using two microchips with different thrombogenic surfaces. PL24-AUC10 levels in the platelet (PL) chip are highly sensitive for platelet functions, while AR10-AUC30 levels in the atheroma (AR) chip allow the assessment of the overall haemostatic ability. vWF large multimer index and T-TAS parameters were decreased in all patients with CF-LVAD. The mean PL24-AUC10 level (5.4 ± 2.9 vs. 219 ± 67; P < 0.01), AR10-AUC30 level (338 ± 460 vs. 1604 ± 160; P < 0.01) and vWF large multimer index (49 ± 11% vs. 112 ± 27%; P < 0.01) were significantly lower in the patients with CF-LVAD than in control patients. One patient showed changes in T-TAS levels before and after implantation of CF-LVAD. PL24-AUC10 and AR10-AUC30 levels decreased from 438.1 to 5.0 and from 1667.9 to 1134.3, respectively. Conclusions: In patients with CF-LVAD, the platelet thrombus-formation capacity was extremely impaired because of AVWS, and T-TAS parameters could detect the presence of AVWS. T-TAS can be used for easy detection of AVWS as a point-of-care testing. Further studies with a large sample size are needed to validate our results in several LVAD models and evaluate the prognostic value of bleeding complications and thromboembolism in patients with LVAD..
4. Sonoda H, Ushijima T, Oishi Y, Tatewaki H, Tanoue Y, Shiose A , Long-term function of Hydrofit® as hemostatic sealant-abridged republication, Asian Cardiovasc Thorac Ann (online published), 2020.10.
5. Tomoki Ushijima, Yoshihisa Tanoue, Kazuto Hirayama, Akira Shiose, Pneumopericardium suggesting left ventricular assist device-related gastrointestinal complication, Journal of Artificial Organs, 10.1007/s10047-020-01154-3, 2020.09, We report an uncommon case of ventricular assist device-related infection and resultant fistula formation into the gastrointestinal tract. A 69-year-old man, who had undergone implantation of a HeartMate II 1 year earlier secondary to ischemic cardiomyopathy, presented to our hospital with a high fever. Computed tomography showed unusual gas collection around the heart apex (i.e., pneumopericardium), which had not been detected before. The patient developed sudden melena with fresh blood without abdominal symptoms 1 month after beginning antibiotic therapy. Emergent colonoscopy showed that the HeartMate II strain relief of the inflow conduit had penetrated the transverse colon. We immediately performed laparoscopy-assisted left-sided hemicolectomy and found intraoperatively that a fistula had formed between the splenic flexure and the pericardial cavity. Subsequently, the HeartMate II system was totally explanted and replaced with an Impella 5.0 for alternative hemodynamic support. In our patient, pneumopericardium might have been an early sign of a hidden gastrointestinal complication. Our experience is a caution for clinicians who manage patients with ventricular assist device support via the apex..
6. Imamura T, Ono M, Kinugawa K, Fukushima N, Shiose A, Matsui Y, Yamazaki K, Saiki Y, Usui A, Niinami H, Matsumiya G, Arai H, Sawa Y, Uriel N, Hemocompatibility-related Adverse Events Following HeartMate II Left Ventricular Assist Device Implantation between Japan and United States, Medicina (Kaunas)(online published), 2020.03.
7. Owada Y, Oshiro Y, Inagaki Y, Harada H, Fujiyama N, Kawagishi N, Yagisawa T, Usui J, Akutsu N, Itabashi Y, Saito K, Watarai Y, Ichimaru N, Imamura R, Kyakuno M, Ide K, Shibuya Y, Okabe Y, Ono M, Sasaki K, Shiose A, Yamagishi K, Ohnishi H, Nagashima S, Takahashi M, Yuzawa K, Okamoto H, Ohkohchi N, A Nationwide Survey of Hepatitis E Virus Infection and Chronic Hepatitis in Heart and Kidney Transplant Recipients in Japan, Transplantation 104(2):437-444, 2020, 2020.02.
8. Ushijima T, Tanoue Y, Mitsuo H, Shiose A., Successful off-pump surgical release for extrinsic compression of outflow graft obstruction of a left ventricular assist device, European Journal of Cardio-Thoracic Surgery 57(2):402-403, 2020.02.
9. Tsutsui H, Isobe M, Ito H, Ito H, Okumura K, Ono M, Kitakaze M, Kinugawa K, Kihara Y, Goto Y, Komuro I, Saiki Y, Saito Y, Sakata Y, Sato N, Sawa Y, Shiose A, Shimizu W, Shimokawa H, Seino Y, Node K, Higo T, Hirayama A, Makaya M, Masuyama T, Murohara T, Momomura SI, Yano M, Yamazaki K, Yamamoto K, Yoshikawa T, Yoshimura M, Akiyama M, Anzai T, Ishihara S, Inomata T, Imamura T, Iwasaki YK, Ohtani T, Onishi K, Kasai T, Kato M, Kawai M, Kinugasa Y, Kinugawa S, Kuratani T, Kobayashi S, Sakata Y, Tanaka A, Toda K, Noda T, Nochioka K, Hatano M, Hidaka T, Fujino T, Makita S, Yamaguchi O, Ikeda U, Kimura T, Kohsaka S, Kosuge M, Yamagishi M, Yamashina A; Japanese Circulation Society and the Japanese Heart Failure Society Joint Working Group, JCS 2017/JHFS 2017 Guideline on Diagnosis and Treatment of Acute and Chronic Heart Failure - Digest Version, Circ J 83(10):2084-2184, 2019, 2019.09.
10. Uchikawa T, Fujino T, Higo T, Ohtani K, Shiose A, Tsutsui H, Cilostazol Is Useful for the Treatment of Sinus Bradycardia and Associated Hemodynamic Deterioration Following Heart Transplantation., Int Heart J.60(5):1222-1225, 2019.09.
11. Tanoue Y, Fujino T, Tatewaki H, Shiose A, Jarvik 2000 axial fow ventricular assist device in right single ventricle after Fontan operation, J Artif Organs 22(4): 338-340,, 2019.08.
12. Sato T, Fujino T, Higo T, Ohtani K, Hiasa KI, Sakamoto T, Chishaki A, Shiose A, Tsutsui H., Flow Pattern of Outflow Graft is Useful for Detecting Pump Thrombosis in a Patient with Left Ventricular Assist Device, Int Heart J.60(4):994-997, 2019.07.
13. Tatewaki H, Hirata Y, Tanoue Y, Shiose A, Pediatric biventricular assist device for myocarditis and complicated left ventricular thrombus, Ann Thorac Surg 107:e307–e308, 2019, 2019.05.
14. Imamura T, Kinugawa K, Ono M, Kinoshita O, Fukushima N, Shiose A, Matsui Y, Yamazaki K, Saiki Y, Usui A, Niinami H, Matsumiya G, Arai H, Sawa Y, Implication of Preoperative Existence of Atrial Fibrillation on Hemocompatibility-Related Adverse Events During Left Ventricular Assist Device Support, Circ J. 83(6):1286-1292, 2019, 2019.05.
15. Onzuka T, Furukawa K, Tayama E, Morita S, Shiose A, Folding procedure to diminish type 3 endoleakage after open stent graft surgery with TEVAR extension, Gen Thorac Cardiovasc Surg (online published), 2019.04.
16. Ushijima T, Tanoue Y, Shiose A, HeartMate II Implantation Via Single Incisional Ministernotomy in a Small Young Woman

, Innovation 14(1):80-83, 2019, 2019.02.
17. Yamamoto T, Ohtani K, Tanoue Y, Shiose A, Tsutsui H, Primary pericardial mesothelioma presenting as constrictive pericarditis, Eur Heart J Cardiovasc Imaging (online published), 2019.01.
18. Inatomi Y, Kadota H, Kaku K, Sonoda H, Tanoue Y, Shiose A, Omental and deep inferior epigastric artery perforator flap coverage after heart transplantation to manage wide left ventricular assist device exposure with pocket infection., J Artif Organs (online published), 2018.12.
19. Yamashita Y, Tatewaki H, Matsumoto T, Shiose A, Axillo-iliac artery bypass for recurrent aortic coarctation to reduce cardiac afterload, Interact CardioVasc Thorac Surg 27(4): 626-628, 2018, 2018.10.
20. Tatewaki H, Shiose A, Pulmonary valve replacement after repaired Tetralogy of Fallot, Gen Thorac Cardiovasc Surg 66(9):509-515, 2018, 2018.09.
21. Yamashita Y, Tatewaki H, Matsumoto T, Shiose A, Axillo-iliac artery bypass for recurrent aortic coarctation to reduce cardiac afterload

Interact CardioVasc Thorac Surg(online published)
, Interact CardioVasc Thorac Surg(online published), 2018.04.
22. Tanoue Y, Fujino T, Shiose A, Anticoagulation Therapy After Left Ventricular Assist Device Implantation, Circ J 82(5):1245-1246, 2018, 2018.04.
23. Yamashita Y, Sonoda H, Ushijima T, Shiose A, Acute torrential mitral regurgitation during transcatheter aortic valve replacement: a case report, Surg Case Rep 4(1): 35, 2018, 2018.04.
24. Uchikawa T, Ohtani K, Muramatsu K, Sonoda H, Shiose A, Tsutsui H, Constrictive Pericarditis and Worsening Mitral Annular Disjunction After Long-Term Chylopericardium, Circulation: Heart Failure (online Published), 2018.01.
25. Kadakia S, Ambur V, Moore R, Toyoda Y, Shiose A, Venovenous extracorporeal membrane oxygenation in two morbidly obese patients, Gen Thorac Cardiovasc Surg 65:594–597, 2017, 2017.10.
26. Ambur VV, Kadakia SS, Taghavi S, Jayarajan SN, Kashem MA, McCarthy J, Shiose A, Wheatley GH, III GH, Toyoda Y, Guy S, Axillary artery access for combined endoaortic balloon occlusion and perfusion during robotic mitral valve surgery
, Innovations 11(3):217-218, 2016, 2016.05.
27. Toyoda Y, Kashem MA, Hisamoto K, Shiose A, Tricuspid valve reconstruction with the extracellular matrix tube technique: a word of caution, J Thorac Cardiovasc Surg 148(2):e141-e143, 2014, 2014.08.
28. Shiose A, Desai P, Criner GJ, Pai S, Steiner RM, Kaiser LR, Guy TS, Toyoda Y, One-and-a-half ventricular repair for isolated right ventricle metastatic tumor resection after lobectomy for lung cancer, Innovations (Phila) 9(4):330-333, 2014, 2014.07.
29. Fukamachi K, Shiose A, Massiello A, Horvath DJ, Golding LA, Lee S, Starling RC, Preload sensitivity in cardiac assist devices, Ann Thorac Surg 95(1):373-380, 2013, 2013.01.
30. Fujiki M, Shiose A, Fukamachi K, Recent advances and patents on chest drainage systems, Recent Patents Biomed Eng 3 (2): 115-120, 2010, 2010.04.
31. Shiose A, Fukamachi K, Recent advances and patents on circulatory support devices for pediatric patients, Recent Patents Biomed Eng 2:161-164, 2009, 2009.04.