Kyushu University Academic Staff Educational and Research Activities Database
List of Books
Masafumi Nakamura Last modified date:2020.04.24

Professor / Dept. Surgery and Oncology / Department of Clinical Medicine / Faculty of Medical Sciences

1. Ohtsuka T, Kimura H, Nakamura M, Nonfunctioning Pancreatic Neuroendocrine Tumors: Diagnosis and Management Principles, John Wiley & Sons, The Pancreas: An Integrated Textbook of Basic Science, Medicine, and Surgery,967-971, 2018.04.
2. Ohtsuka T, Kimura H, Nakamura M, Interventional Radiology in the Treatment of Pancreatic Neuroendocrine Tumors, John Wiley&Sons, The Pancreas: An Integrated Textbook of Basic Science, Medicine, and Surgery,979-981, 2018.04.
3. Fujimoto T, Ohtsuka T, Nakamura M, Chapter17:Elevation of Pancreatic Enzymes in Bile of PBM, Springer Singapore, 10.1007/978-981-10-8654-0_17, Springer Singapore,137-144, 2018.04, Abstract:Pancreaticobiliary maljunction (PBM) is a congenital anomaly in which the reciprocal reflux between pancreatic and bile juice occurs because the conflu- ence of the pancreatic and bile ducts lies outside of the area of contractile influence of the sphincter of Oddi. The reflux of pancreatic juice into the bile duct and subse- quent elevated pancreatic enzyme level in bile are usually recognized in PBM. Amylase is the most popular pancreatic enzyme for assessment in daily prac- tice, and assessment of amylase level in bile is useful to definitively confirm the presence of PBM, and the mixture of pancreatic and bile juices may produce various physiological and pathological alterations. In PBM, the amylase level in bile in patients with biliary cancers has been reported to be higher than that with benign biliary diseases; however, the relationship between the amylase level in bile and development of biliary diseases has not been well documented. Recently, several studies have demonstrated that some patients with a normal morphological pancre- aticobiliary junction have a high amylase level and biliary carcinoma. This suggests the possibility that pancreaticobiliary reflux can occur even in patients without PBM and result in the development of biliary carcinoma in the same manner as in patients with PBM.
4. Okumura T, Ohuchida K, Nakamura M, An In Vitro Three-Dimensional Organotypic Model to Analyze Peripancreatic Fat Invasion in Pancreatic Cancer: A Culture System Based on Collagen Gel Embedding, Humana Press, 10.1007/978-1-4939-8879-2_11 , Methods Mol Biol.,1882:135-141, 2018.04, Abstract
Three-dimensional culture systems reflect biological environments better than conventional two-dimensional culture. Additionally, three-dimensional culture is a strong experimental tool to analyze direct interactions between cancer cells and stromal cells in vitro. Herein, we describe protocols for an organotypic fat invasion model that is a novel culturing system mimicking the extrapancreatic invasion of pancreatic adenocarcinoma (PDAC). This novel model is based on the collagen I gel embedding method and enables us to analyze the functional and histological interactions between cancer cells and adipose tissue.