慢性疼痛診療における医療不信の影響
キーワード:医療不信 愛着
2020.04~2025.03.
細井 昌子(ほそい まさこ) | データ更新日:2023.12.06 |
主な研究テーマ
慢性疼痛の心理社会的因子を反映する投影法(PRISMおよびサークルドローイング法)の開発
キーワード:プリズム、サークルドローイング、心理社会的因子、投影法
2005.04~2024.03.
キーワード:プリズム、サークルドローイング、心理社会的因子、投影法
2005.04~2024.03.
慢性疼痛に対する脳波を用いたニューロフィードバック法の開発
キーワード:ニューロフィードバック、脳波、慢性疼痛
2021.09~2024.03.
キーワード:ニューロフィードバック、脳波、慢性疼痛
2021.09~2024.03.
悪夢が慢性疼痛および中枢性感作に与える影響
キーワード:悪夢、慢性疼痛、中枢性感作、トラウマ、睡眠ステージ、体動センサー
2020.06~2024.03.
キーワード:悪夢、慢性疼痛、中枢性感作、トラウマ、睡眠ステージ、体動センサー
2020.06~2024.03.
慢性疼痛のトランスレーショナルリサーチ :精神心理学的・神経免疫学的側面からの病態解明と評価法開発
キーワード:慢性疼痛、心理、マイクログリア
2014.06~2020.03.
キーワード:慢性疼痛、心理、マイクログリア
2014.06~2020.03.
慢性疼痛のコホート研究
キーワード:後ろ向き観察研究、痛み質問紙
2014.06~2024.03.
キーワード:後ろ向き観察研究、痛み質問紙
2014.06~2024.03.
慢性疼痛に関する脳画像研究
キーワード:デフォルトモードネットワーク、VBM
2014.06~2014.06.
キーワード:デフォルトモードネットワーク、VBM
2014.06~2014.06.
生活習慣病とアレキシサイミア、養育スタイルおよび肯定的感情に関する臨床的および疫学研究
キーワード:疫学; 養育; 生活習慣病; 失感情症
2009.04~2012.03.
キーワード:疫学; 養育; 生活習慣病; 失感情症
2009.04~2012.03.
慢性疼痛における破局化とアレキシサイミアに関する研究
キーワード:慢性疼痛、破局化、アレキシサイミア
2007.04~2012.03.
キーワード:慢性疼痛、破局化、アレキシサイミア
2007.04~2012.03.
慢性疼痛の評価法の開発
キーワード:痛み、質問紙
2003.04.
キーワード:痛み、質問紙
2003.04.
従事しているプロジェクト研究
The development of chronic pain coping inventory-Japanese version (CPCI-J)
2012.07~2017.12, 代表者:Masako Hosoi, Dept of Psychosomatic Medicine, Kyushu University Hospital, Japan
慢性疼痛に対する対処法についての質問紙 Chronic Pain Coping Inventory 日本語版の作成
原著者であるワシントン大学リハビリテーション学科のMark P Jensen教授との共同研究.
2012.07~2017.12, 代表者:Masako Hosoi, Dept of Psychosomatic Medicine, Kyushu University Hospital, Japan
慢性疼痛に対する対処法についての質問紙 Chronic Pain Coping Inventory 日本語版の作成
原著者であるワシントン大学リハビリテーション学科のMark P Jensen教授との共同研究.
研究業績
主要著書
主要原著論文
1. | Satoshi Izuno, Kazufumi Yoshihara, Masako Hosoi, Sanami Eto, Naoki Hirabayashi, Tae Todani, Motoharu Gondo, Chie Hayaki, Kozo Anno, Akio Hiwatashi, Nobuyuki Sudo, Psychological characteristics associated with the brain volume of patients with fibromyalgia, Biopsychosoc Med. 2023 Oct 24;17(1):36., doi: 10.1186/s13030-023-00293-2., 2023 Oct 24;17(1):36., 2023.10. |
2. | Saito T, Shibata M, Hirabayashi N, Honda T, Morisaki Y, Anno K, Sudo N, Hosoi M, Ninomiya T., Family dysfunction is associated with chronic pain in a community-dwelling Japanese population: The Hisayama study, European Journal of Pain, 518-529, 2023.04. |
3. | Tomioka, M., Hosoi, M., Okuzawa, T., Anno, K., Iwaki, R., Kawata, H., Kubo, C. & Sudo, N., The effectiveness of Pictorial Representation of Illness and Self Measure (PRISM) for the assessment of the suffering and quality of interpersonal relationships of patients with chronic pain, BioPsychoSocial Medicine, doi: 10.1186/s13030-021-00223-0., 15, 1, PMID: 34801076, 2022.01. |
4. | Koji Fujimoto, Masako Hosoi, Ryoko Katsuki, Toshio Matsushima, Keitaro Matsuo, Tomohiro Nakao, Nobuyuki Sudo, Takahiro A. Kato, Psychological traits of patients with depression comorbid with chronic pain: Are Complaint and Competitive tendency related to pain?, Frontiers in Psychiatry, section Psychological Therapy and Psychosomatics, Manuscript ID: 825422, 2022.01. |
5. | Mao Shibata, Tomoyuki Ohara, Masako Hosoi, Hata Jun, Daigo Yoshida, Naoki Hirabayashi, Yukiko Morisaki, Taro Nakazawa, Akane Mihara, Takuya Nagata, Emi Oishi, Kozo Anno, Nobuyuki Sudo, Toshiharu Ninomiya, Emotional loneliness is associated with a risk of dementia in a general Japanese older population: the Hisayama Study, The Journals of Gerontology, Series B: Psychological Sciences and Social Sciences, 10.1093/geronb/gbaa196, 2020 Nov 10, gbaa196., 2020.11, Objectives: To investigate the association of loneliness and its component subscales with the risk of dementia in a general Japanese older population. Method: A total of 1,141 community-dwelling Japanese residents aged ≥65 years without dementia were prospectively followed up for a median 5.0 years. We evaluated any loneliness and its component subscales-namely, social and emotional loneliness-by using the 6-Item de Jong Gierveld Loneliness Scale. Cox proportional hazards models were used to estimate hazard ratios (HRs) of each loneliness type on the risk of dementia controlling for demographic factors, lifestyle factors, physical factors, social isolation factors, and depression. Results: During the follow-up, 114 participants developed dementia. The age- and sex-adjusted incidence rate of dementia was significantly greater in participants with any loneliness and emotional loneliness than those without. The multivariable-adjusted HRs (95% confidence intervals) of participants with any loneliness and emotional loneliness on incident dementia were 1.61 (1.08-2.40) and 1.65 (1.07-2.54), respectively, as compared to those without. However, there was no significant association between social loneliness and dementia risk. In subgroup analyses of social isolation factors, excess risks of dementia associated with emotional loneliness were observed in participants who had a partner, lived with someone, or rarely communicated with relatives or friends, but such association was not significant in participants who had no partner, lived alone, or frequently communicated with friends or relatives. Discussion: The present study suggested that loneliness, especially emotional loneliness, was a significant risk factor for the development of dementia in the general older population in Japan. Keywords: alienation; communication; epidemiology; prospective cohort study; social exclusion.. |
6. | Shibata M, Ninomiya T, Anno K, Kawata H, Iwaki R, Sawamoto R, Kubo C, Kiyohara Y, Sudo N, Hosoi M., Parenting style during childhood is associated with the development of chronic pain and a patient's need for psychosomatic treatment in adulthood., Medicine 99 (29) 2020 7.17, p e21230, 2020.07. |
7. | 田中佑、安野広三、早木千絵、西原智恵、柴田舞欧、岩城理恵、須藤信行、細井昌子, 慢性疼痛患者への心身医学的介入の効果:初診時における「過去の医療不信」が痛みの破局化の改善に関連する, 慢性疼痛, 38, 1, 104-110, 2019.12. |
8. | Ohgidani M, Kato TA, Hosoi M, Tsuda M, Hayakawa K, Hayaki C, Iwaki R, Sagata N, Hashimoto R, Inoue K, Sudo N, Kanba S, Fibromyalgia and microglial TNF-α: Translational research using human blood induced microglia-like cells, Scientific Reports, 10.1038/s41598-017-11506-4, 19;7(1):11882, 2017.09. |
9. | Valentina Tesio, Katharina S. Goerlich, Masako Hosoi, Lorys Castelli, Editorial Alexithymia: State of the art and controversies. Clinical and neuroscientific evidence, Frontiers in Psychology, 10.3389/fpsyg.2019.01209, 10, MAY, 2019.01, [URL]. |
10. | Chie Hayaki, Kozo Anno, Mao Shibata, Rie Iwaki, Hiroshi Kawata, Nobuyuki Sudo, Masako Hosoi, Family dysfunction A comparison of chronic widespread pain and chronic localized pain, MEDICINE, 10.1097/MD.0000000000005495, 95, 49, 2016.12. |
11. | Shibata M, Ninomiya T, Anno K, Kawata H, Iwaki R, Sawamoto R, Kubo C, Kiyohara Y, Sudo N, Hosoi M, Perceived inadequate care and excessive overprotection during childhood are associated with greater risk of sleep disturbance in adulthood: the Hisayama Study, BMC PSYCHIATRY, 10.1186/s12888-016-0926-2, 16, 2016.07. |
12. | Anno K, Shibata M, Ninomiya T, Iwaki R, Kawata H, Sawamoto R, Kubo C, Kiyohara Y, Sudo N, Hosoi M, Paternal and maternal bonding styles in childhood are associated with the prevalence of chronic pain in a general adult population: the Hisayama Study, BMC PSYCHIATRY, 10.1186/s12888-015-0574-y, 15, 2015.07. |
13. | Shibata M, Ninomiya T, Jensen MP, Anno K, Yonemoto K, Makino S, Iwaki R, Yamashiro K, Yoshida T, Imada Y, Kubo C, Kiyohara Y, Hosoi M, Sudo N, Alexithymia is Associated with Greater Risk of Chronic Pain and Negative Affect and with Lower Life Satisfaction in a General Population: The Hisayama Study, PLOS ONE, 10.1371/journal.pone.0090984, 9, 3, 2014.03. |
14. | Makino Seiko, Jensen Mark P., Arimura Tatsuyuki, Obata Tetsuji, Anno Kozo, Iwaki Rie, Kubo Chiharu, SUDO Nobuyuki, Hosoi Masako, Alexithymia and Chronic Pain The Role of Negative Affectivity, The Clinical Journal of Pain, 10.1097/AJP.0b013e3182579c63, 29, 4, 354-361, 2013.04. |
15. | Toshiyuki Yoshida, Ivan R. Molton, Mark P. Jensen, Tomoyasu Nakamura, Tatsuyuki Arimura, Chiharu Kubo, Masako Hosoi, Cognitions, metacognitions, and chronic pain, Rehabilitation Psychology, 10.1037/a0028903, 57, 3, 207-213, 2012.08, [URL], Purpose: Although the content of thoughts has received a considerable amount of attention in pain research, the importance of thought processes (metacognitions) has received less attention. Method: One hundred twenty-nine individuals with muscular dystrophy and chronic pain completed measures assessing metacognitions and frequency of both catastrophizing and pain control beliefs. Results: Greater use of reappraisal and distraction metacognitions were associated with more perceived control over pain, whereas greater use of worry and punishment metacognitions were associated with more catastrophizing. Conclusions/Implications: The current findings indicate that metacognitions are associated with both pain control beliefs and catastrophizing and therefore may play an important role in the development or maintenance of pain-related cognitive content thought to influence patient functioning. Research is needed to determine whether treatments that encourage changes in both metacognitions and cognitive content are more effective than treatments that focus on cognitive content alone.. |
16. | Rie Iwaki, Tatsuyuki Arimura, Mark P. Jensen, Tomoyasu Nakamura, Koji Yamashiro, Seiko Makino, Tetsuji Obata, Nobuyuki Sudo, Chiharu Kubo, Masako Hosoi, Global Catastrophizing vs Catastrophizing Subdomains Assessment and Associations with Patient Functioning, Pain Medicine (United States), 10.1111/j.1526-4637.2012.01353.x, 13, 5, 677-687, 2012.05, [URL], Objective. The primary objectives of the current study were to 1) confirm the three-factor model of the Pain Catastrophizing Scale (PCS) items in a Japanese sample and 2) identify the catastrophizing subdomain(s) most closely associated with measures of pain and functioning in a sample of individuals with chronic pain. Design. This was based on a cross-sectional observational study. Setting. This study was conducted in a university-based clinic. Patients. One hundred and sixty outpatients with chronic pain participated in this study. Outcome Measures. Patients completed the PCS, the Brief Pain Inventory, and the Hospital Anxiety and Depression Scale; 30 patients completed the PCS again between 1 and 4 weeks later. Results. Confirmatory factor analysis supported a three-factor structure of the Japanese version of the PCS, and univariate and multivariate associations with validity criterion supported the validity of the measure. Catastrophic helplessness was shown to make a unique contribution to the prediction of pain intensity, pain interference and depression, and catastrophic magnification made a unique contribution to the prediction of anxiety. Conclusions. The findings support the cross-cultural generalizability of the three-factor structure of the PCS and indicate that the PCS-assessed catastrophizing subdomains provide greater explanatory power than the PCS total score for understanding pain-related functioning. Wiley Periodicals, Inc.. |
17. | Tatsuyuki Arimura, Masako Hosoi, Yoshihiro Tsukiyama, Toshiyuki Yoshida, Daiki Fujiwara, Masanori Tanaka, Ryuichi Tamura, Yasunori Nakashima, Nobuyuki Sudo, Chiharu Kubo, Pain Questionnaire Development Focusing on Cross-Cultural Equivalence to the Original Questionnaire The Japanese Version of the Short-Form McGill Pain Questionnaire, Pain Medicine, 10.1111/j.1526-4637.2012.01333.x, 13, 4, 541-551, 2012.04, [URL], Objectives. The present study aimed to develop a Japanese version of the Short-Form McGill Pain Questionnaire (SF-MPQ-J) that focuses on cross-culturally equivalence to the original English version and to test its reliability and validity. Design. Cross-sectional design. Method. In study 1, SF-MPQ was translated and adapted into Japanese. It included construction of response scales equivalent to the original using a variation of the Thurstone method of equal-appearing intervals. A total of 147 undergraduate students and 44 pain patients participated in the development of the Japanese response scales. To measure the equivalence of pain descriptors, 62 pain patients in four diagnostic groups were asked to choose pain descriptors that described their pain. In study 2, chronic pain patients (N=126) completed the SF-MPQ-J, the Long-Form McGill Pain Questionnaire Japanese version (LF-MPQ-J), and the 11-point numerical rating scale of pain intensity. Correlation analysis examined the construct validity of the SF-MPQ-J. Results. The results from study 1 were used to develop SF-MPQ-J, which is linguistically equivalent to the original questionnaire. Response scales from SF-MPQ-J represented the original scale values. All pain descriptors, except one, were used by >33% in at least one of the four diagnostic groups. Study 2 exhibited adequate internal consistency and test-retest reliability, with the construct validity of SF-MPQ-J comparable to the original. Conclusion. These findings suggested that SF-MPQ-J is reliable, valid, and cross-culturally equivalent to the original questionnaire. Researchers might consider using this scale in multicenter, multi-ethnical trials or cross-cultural studies that include Japanese-speaking patients. Wiley Periodicals, Inc... |
18. | Koji Yamashiro, Tatsuyuki Arimura, Rie Iwaki, Mark P. Jensen, Chiharu Kubo, Masako Hosoi, A multidimensional measure of pain interference Reliability and validity of the pain disability assessment scale, Clinical Journal of Pain, 10.1097/AJP.0b013e318204858a, 27, 4, 338-343, 2011.05, [URL], Objective: Measuring outcomes across multiple domains is essential for an adequate understanding of chronic pain and the effects of pain treatment. Pain interference reflects the negative effects of pain on functioning, and is recognized as a critical outcome domain. The Pain Disability Assessment Scale (PDAS) contains items that assess the negative effects of pain on broad spectrum pain interference domains. The purpose of this study was to examine the factor structure, reliability, and validity of the PDAS. Methods: One hundred sixty-four Japanese patients with chronic pain were administered the PDAS, the Brief Pain Inventory, and the Hospital Anxiety and Depression Scale. Results: The findings support a 3 factor structure of the PDAS items, as well as a high level of internal consistency of the scales created from these factors (Cronbach αs range: 0.87 to 0.95). Validity of the 3 scales was supported through their significant associations, in hypothesized directions, with measures of pain intensity, anxiety, depression, and another established measure of pain interference, as well as differences in PDAS scores between patients with versus without back pain. Conclusions: The PDAS may be useful when researchers or clinicians require a multidimensional measure of the effects of pain on a patients life.. |
19. | Masako Hosoi, Ivan R. Molton, Mark P. Jensen, Dawn M. Ehde, Silvia Amtmann, Sarah O'Brien, Tatsuyuki Arimura, Chiharu Kubo, Relationships among alexithymia and pain intensity, pain interference, and vitality in persons with neuromuscular disease Considering the effect of negative affectivity, Pain, 10.1016/j.pain.2010.02.012, 149, 2, 273-277, 2010.05, [URL], Alexithymia, the inability to identify or label emotions, has been shown to be associated with pain in patients with a number of chronic pain conditions. We sought to: (1) replicate this association in samples of persons with chronic pain secondary to neuromuscular disease, (2) extend this finding to other important pain-related measures, and (3) to determine whether relationships among alexithymia and study variables existed after controlling for negative affect. One hundred and twenty-nine individuals with muscular dystrophy and chronic pain were administered measures of alexithymia (Toronto Alexithymia Scale, TAS-20), pain intensity (0-10 NRS), pain interference (Brief Pain Inventory Interference scale), mental health (SF-36 Mental Health scale; as a proxy measure of negative affect) and vitality (SF-36 Vitality scale). Higher TAS scores were associated significantly with higher pain intensity and interference, and less vitality. Although the strengths of these associations were reduced when mental health was used as a control, the associations between the Difficulty Identifying Feelings scale and vitality, and the Externally Oriented Thinking and Total TAS scales and pain intensity remained statistically significant. The findings replicate and extend previous findings concerning the associations between alexithymia and important pain-related variables in a sample of persons with chronic pain and neuromuscular disease. Future research is needed to determine the extent to which the associations are due to (1) a possible causal effect of alexithymia on patient functioning that is mediated via its effects on negative affect or (2) the possibility that alexithymia/outcome relationships reflect response bias caused by general negative affectivity.. |
20. | Wei Xiong, Masako Hosoi, Bon Nyeo Koo, Li Zhang, Anandamide inhibition of 5-HT3A receptors varies with receptor density and desensitization, Molecular Pharmacology, 10.1124/mol.107.039149, 73, 2, 314-322, 2008.02, [URL], Converging evidence has suggested that anandamide (AEA), an endogenous agonist of cannabinoid (CB) receptors, can directly interact with certain types of ligand-gated ion channels (LGICs). However, little is known about the molecular and cellular mechanisms of AEA-induced direct effects on LGICs. Here, we report that AEA inhibited the function of serotonin-gated ion channels (5-HT3A) expressed in Xenopus laevis oocytes and human embryonic kidney 293 cells in a manner that was dependent on the steady-state receptor density at the cell surface. The magnitude of AEA inhibition was inversely correlated with the expression levels of receptor protein and function. With increasing surface receptor expression, the magnitude of AEA inhibition decreased. Consistent with this idea, pretreatment with actinomycin D, which inhibits transcription, decreased the amplitude of current activated by maximal concentrations of 5-hydroxytryptamine (5-HT) and increased the magnitude of AEA inhibition. AEA did not significantly alter 5-HT3A receptor trafficking. However, AEA accelerated 5-HT3A receptor desensitization time in a concentration-dependent manner without significantly changing receptor activation and deactivation time. The desensitization time was correlated with the AEA-induced inhibiting effect and mean 5-HT current density. Applications of 5-hydroxyindole and nocodazole, a microtubule disruptor, significantly slowed 5-HT3A receptor desensitization and reduced the magnitude of AEA inhibition. These observations suggest that 5-HT3 receptor density at the steady state regulates receptor desensitization kinetics and the potency of AEA-induced inhibiting effect on the receptors. The inhibition of 5-HT3 receptors by AEA may contribute to its physiological roles in control of pain and emesis.. |
21. | Hayashi H, Mine K, Hosoi M, Tsuchida O, Handa M, Kinukawa N, Andou K, Kubo C, Comparison of the esophageal manometric characteristics of idiopathic and reflux-associated esophageal spasm: evaluation by 24-hour ambulatory esophageal motility and pH monitoring., Digestive Diseases and Sciences, 10.1023/B:DDAS.0000004514.91064.7f, 48, 11, 2124-2131, 48 (11) : 2124-2131, 2003.11. |
22. | Yoshio Kanemitsu, Masako Hosoi, Ping Jun Zhu, Forrest F. Weight, Robert W. Peoples, Joseph S. McLaughlin, Li Zhang, Dynorphin A inhibits NMDA receptors through a pH-dependent mechanism, Molecular and Cellular Neuroscience, 10.1016/S1044-7431(03)00214-8, 24, 3, 525-537, 2003.01, [URL], Dynorphin A (DynA), an endogenous agonist of κ-opioid receptors, has also been reported to directly interact with the NMDA receptor. DynA inhibition of NMDA receptor function has been suggested to be involved in its neuroprotective action during ischemic and acidic conditions. However, the effect of external pH on DynA inhibition of the NMDA receptor has not been reported. Here, we show that DynA inhibition of the NMDA receptor is dependent on extracellular pH over the range of pH 6.7-8.3, and the inhibition by 10 μM DynA increases at low pH by three- to four-fold in hippocampal neurons and in Xenopus oocytes expressing NR1-1a/2B subunits. Molecular studies showed that the interacting site for DynA on the NMDA receptor is distinct from that of proton or redox sites. Peptide mapping demonstrated important contributions of positively charged residues and specific structural organization of the peptide to the potency of DynA inhibition. Thus, DynA inhibits NMDA receptors through an allosteric mechanism, which is pH dependent and involves the specific structural features of the peptide.. |
23. | Hosoi M, Oka T, Abe M, Hori T, Yamamoto H, Mine K, Kubo C, Prostaglandin E2 has antinociceptive effect through EP1 receptor in the ventromedial hypothalamus in rats, Pain, 10.1016/S0304-3959(99)00105-0, 83, 2, 221-227, 83 (4) : 221-227, 1999.11. |
24. | Hosoi M, Oka T, Hori T, Prostaglandin E receptor EP3 subtype is involved in thermal hyperalgesia through its actions in the preoptic hypothalamus and the diagonal band of Broca, Pain, 10.1016/S0304-3959(97)03380-0, 71, 3, 303-311, 71 : 303-311, 1997.07. |
25. | 有村達之、小宮山博朗、細井昌子, 疼痛生活障害評価尺度の開発, 行動療法研究, 23 (1) : 7-15, 1997.03. |
26. | H. Komiyama, M. Muraoka, K. Mine, H. Hayakawa, M. Hosoi, T. Nakagawa, K. Kodama, C. Kubo, Psychosomatic study on chronic pain. Consideration of the treatment and prognosis, Japanese Journal of Psychosomatic Medicine, 35, 4, 287-297, 1995.01, In the department of psychosomatic medicine, Kyushu University, a chronic pain patient is defined as 'a patient whose pain complaint or social or occupational impairment is in excess of what would be expected from the underlying organic pathology.' We have treated patients of this category by means of various kinds of somatic, psychologic and psychiatric methods. In this paper, 40 cases who had been treated for chronic pain on an inpatient basis in our institute were studied regarding applied treatment methods, their effect, treatment outcome and factors affecting prognosis. The results are as follows: 1) All the subjects were prescribed several kinds of antidepressants and minor tranquilizers as pharmacological treatment with the aim of alleviating the pain. 2) The somatic approach consisted of nerve block, laser and silver spike point electro therapy, all of which were applied to the patients with neurogenic pain. We feel that these methods also have some psychological effect. 3) Some behavioral methods were applied, such as autogenic training (AT), graded exercise quota and other operant techniques (time-out, prompting and token economy). AT helped the patients to effectively cope with pain caused by depressive disorders and psychophysiological mechanisms. Graded exercise quota was applied to teach patients to effectively manage avoidance pain behaviors to fearful situations. Other operant techniques were necessary for controlling more excessive pain behaviors. 4) In addition, some patients received either family therapy or counseling. The former was effective both for patients with depressive disorders whose family system acted as a psychological burden and for patients with conversion disorders who utilized their pain as a communication method. Counseling was necessitated for patients whose interpersonal cognitions were distorted or whose social skills were immature. 5) Treatment outcomes were evaluated from following four aspects; the strength of the subjective pain, the degree of the impairment of daily activity or role functioning and the dependence on medical treatments. Evaluation of the short-term outcome at 1-month after discharge showed 3 excellent, 14 good, 19 fair and 4 poor cases. Evaluation of the long-term outcome at 6-12 months revealed 5 excellent, 18 good, 10 fair and 7 poor cases. 6) Examination of factors affecting prognosis suggested that the most important was to analyse the patients' pain problems from a detailed multiphasic view and to institute the appropriate treatment on the basis of that analysis. On the basis of these results, the possibility was discussed as to how to apply various methods systemically, such as somatic approach, pharmacological treatment, behavioral therapy, family therapy and other psychotherapy, depending on the patients' pathogenesis.. |
27. | H. Komiyama, M. Muraoka, K. Mine, H. Hayakawa, M. Hosoi, T. Nakagawa, K. Kodama, C. Kubo, Psychosomatic study on chronic pain. Clinical features of chronic pain and reconsideration on its definition, Japanese Journal of Psychosomatic Medicine, 34, 6, 489-498, 1994.01, In the Department of Psychosomatic Medicine, Kyushu University, a chronic pain patient is defined on the basis of our clinical experiences and reviews of associated literatures as 'the patient whose pain complaint or social or occupational impairment is in excess of what would be expected from the underlying organic pathology'. We assessed the pathogenesis of each patient in this category based on a multidimensional evaluation including organic, functional and psychiatric diagnosis, as well as behavioral analysis and family analysis. In this paper, 40 cases who had been treated as having chronic pain on inpatient basis in our institute were studied regarding their clinical features. The results are as follows: 1) Before the first visit to us, they underwent various treatments at many institutes and several admissions. In addition, some cases underwent one or more operations for alleviation of the pain in vain. 2) An operation for a physical disease, a psychosocial stressor, an injury and a disease with no need of operation were considered to have functioned as the precipitating factor for the pain. Many patients developed their pain from an experience of a noxious stimulus as a trigger. 3) psychiatric diagnosis made according to DSM-III-R showed that conversion disorder and major depression were the two most common disorders and that a few cases had hypochondriasis or social phobia. These psychiatric disorders led to the pain of the patients. As accompanying psychiatric diseases, there existed psychoactive substance abuse, panic disorder, factitious disorder or others on Axis I and some kinds of personality disorder on Axis II. 4) As functional diseases, there were deafferentation pain, reflex sympathetic dystrophy, tension-type headache, irritable bowel syndrome, non-ulcer dyspepsia and aerophagia. 5) The comparison between the characteristics of depressive disorder and those of conversion disorder revealed that patients with depressive disorder were significantly more related to experience of a noxious stimulus. 6) Behavioral analysis suggested that operant learning mainly played a causative role in the pain behaviors of many cases. 7) In the operant pain patients, 4 types of consequence in their environment acted as reward contingent on their pain behaviors. These included solicitous response, avoidance of reality, avoidance of conflict and maintenance of family system. These results suggest that there exists a complicated pathogenesis consisting of various factors behind persistent and intractable pain. Therefore, it is necessary to evaluate chronic pain patients on the basis of detailed psychosomatic assessment. It is thus considered to be important to attempt to understand the psychological, social and existentional meanings of each patient's pain.. |
主要総説, 論評, 解説, 書評, 報告書等
主要学会発表等
学会活動
所属学会名
国際疼痛学会
北米神経科学会
日本内科学会
日本心身医学会
日本疼痛学会
日本慢性疼痛学会
日本運動器疼痛学会
日本線維筋痛症学会
日本ストレス学会
日本自律訓練学会
日本心療内科学会
日本疼痛心身医学会
日本認知行動療法学会
日本統合医療学会
日本公衆衛生学会
学協会役員等への就任
2022.12~2024.11, 日本疼痛学会, 理事.
2022.06~2023.03, 日本線維筋痛症学会, 理事.
2008.12~2023.11, 日本運動器疼痛学会, 理事.
2016.06~2023.05, 日本疼痛学会, 代議員.
2011.04~2023.03, 日本慢性疼痛学会, 理事.
2010.04~2020.03, 日本疼痛心身医学会, 理事.
2004.06~2024.05, 日本心身医学会, 評議員.
2012.04~2023.11, 日本心療内科学会, 評議員.
2008.09, 日本心身医学会, 運営委員.
2016.12~2018.11, 日本心療内科学会, 運営委員.
2012.04~2020.03, 日本ストレス学会, 評議員.
2008.04, 日本心身医学会, 運営委員.
2014.09~2019.11, 日本自律訓練学会, 評議員.
学会大会・会議・シンポジウム等における役割
2023.03.10~2023.03.11, 第52回 日本慢性疼痛学会, 大会長.
2022.01.30~2022.01.30, 第61回日本心身医学会九州地方会, プログラム委員.
2022.01.30~2022.01.30, 第61回日本心身医学会九州地方会, 教育講演 座長 .
2021.07.22~2021.07.24, 第55回日本ペインクリニック学会 シンポジウム 線維筋痛症の病態解析の最前線, 座長.
2021.07.10~2021.07.11, 第62回 日本心身医学会 シンポジウム 痛みと心理社会的ストレス:From Bed to Bench, 座長.
2021.07.10~2021.07.11, 第62回 日本心身医学会 教育講演にて 岡田クリニック 岡田 尊司先生 愛着関連障害と愛着アプローチ-「医学モデル」から「愛着モデル」へのパラダイムシフト-, 座長.
2021.03.19~2021.03.20, 第50回日本慢性疼痛学会 ワークショップ3「Nociplastic pain」, 座長.
2021.01.31~2021.01.31, 第60回 日本心身医学会九州地方会 シンポジウム1「慢性疼痛治療の視点から心身医学の未来を見据える」, 座長.
2020.02.08~2020.02.09, 第59回 日本心身医学会 九州地方会, プログラム委員.
2020.02.08~2020.02.09, 第59回 日本心身医学会 九州地方会, 一般演題 座長.
2019.11.15~2020.11.17, 第2回 日本心身医学関連学会合同集会 シンポジウム, 座長.
2019.09.29~2019.09.29, 第11回 慢性痛の心理アセスメント研究会, 会長.
2019.02.15~2019.02.15, 第10回 慢性痛の心理アセスメント研究会, 会長.
2019.02.15~2019.02.16, 第48回 日本慢性疼痛学会, 一般演題 心理的アプローチ1 座長.
2018.12.01~2019.06.26, 第11回 日本運動器疼痛学会, 教育研修講演 座長.
2018.06.08~2019.06.09, 第59回 日本心身医学会総会, 一般演題 疼痛 座長.
2016.12.03~2016.12.04, 第21回日本心療内科学会総会・学術大会, 座長(Chairmanship).
2016.06.04~2016.06.05, 第57回日本心身医学会総会ならびに学術講演会, 座長(Chairmanship).
2016.02.26~2016.02.26, 第6回 慢性痛の心理アセスメント研究会, 会長.
2016.01.23~2016.01.24, 第55回心身医学会 九州地方会, 座長(Chairmanship).
2015.12.12~2015.12.13, 第8回日本運動器疼痛学会, 座長(Chairmanship).
2015.11.21~2015.11.21, 第20回日本心療内科学会総会・学術大会, 座長(Chairmanship).
2015.09.13~2015.09.13, 第5回 慢性痛の心理アセスメント研究会, 会長.
2015.07.03~2015.07.04, 第37回日本疼痛学会, 座長(Chairmanship).
2015.06.26~2015.06.27, 第56回日本心身医学会総会ならびに学術講演会, 座長(Chairmanship).
2015.02.27~2015.02.27, 第4回 慢性痛の心理アセスメント研究会, 会長.
2014.08.24~2014.08.24, 第3回 慢性痛の心理アセスメント研究会, 会長.
2014.07.24~2014.07.26, 日本ペインクリニック学会第48回大会, 座長(Chairmanship).
2014.02.21~2014.02.21, 第2回 慢性痛の心理アセスメント研究会, 会長.
2014.02.21~2014.02.22, 第43回日本慢性疼痛学会, 座長(Chairmanship).
2014.01.25~2014.01.26, 第53回日本心身医学会九州地方会, 座長(Chairmanship).
2013.12.07~2013.12.08, 第6回日本運動器疼痛学会, 座長(Chairmanship).
2013.06.26~2013.06.27, 第54回日本心身医学会総会ならびに学術講演会, 座長(Chairmanship).
2013.05.19~2013.05.19, 第1回 慢性痛の心理アセスメント研究会.
2013.02.22~2013.02.23, 第42回日本慢性疼痛学会, 座長(Chairmanship).
2013.02.22~2013.02.23, 第42回日本慢性疼痛学会, 座長(Chairmanship).
2013.02.09~2013.02.10, 第52回日本心身医学会九州地方会, 座長(Chairmanship).
2012.05.25~2012.05.26, 第53回日本心身医学会総会, 座長(Chairmanship).
2012.02.18~2012.02.19, 第41回日本慢性疼痛学会, 座長(Chairmanship).
2011.11.19~2011.11.20, 第4回日本運動器疼痛学会, 座長(Chairmanship).
2011.06.09~2011.06.10, 第52回日本心身医学会総会ならびに学術講演会, 座長(Chairmanship).
2011.02.25~2011.02.26, 第40回日本慢性疼痛学会, 座長(Chairmanship).
2010.11.13~2010.11.14, 日本線維筋痛症学会 第2回学術集会, 座長(Chairmanship).
2010.09.10~2010.09.12, 第14回アジア心身医学会, 座長(Chairmanship).
2010.03.26~2010.05.27, 第4回身体疾患とうつ病研究会, 座長(Chairmanship).
2010.02.26~2010.02.27, 日本慢性疼痛学会, 座長(Chairmanship).
2010.02.06~2010.02.07, 日本心身医学会九州地方会, 座長(Chairmanship).
2010.01.23~2010.01.23, 第8回西日本心療内科未来研究会, 座長(Chairmanship).
2009.11.07~2009.11.07, 第2回日本運動器疼痛研究会, 座長(Chairmanship).
2009.06.06~2009.06.07, 第1回日本心身医学 5学会合同集会, 座長(Chairmanship).
2008.10~2008.10, 第7回西日本心療内科未来研究会, 座長(Chairmanship).
2008.03, 第81回 日本薬理学会年会, シンポジスト.
2007.10, 第6回 西日本心療内科未来研究会, 司会(Moderator).
2007.05, 第48回 日本心身医学会総会 教育セミナー, 座長(Chairmanship).
2007.05, 第48回 日本心身医学会総会, 座長(Chairmanship).
2006.10, 第5回 西日本心療内科未来研究会, 座長(Chairmanship).
2006.05, 第47回 日本心身医学会総会, 座長(Chairmanship).
2005.05, 第46回 日本心身医学会, コメンテーター.
2004.06, 第45回 日本心身医学会, 座長(Chairmanship).
学会誌・雑誌・著書の編集への参加状況
2015.07~2022.07, BioPsychoSocial Medicine, 国際, 査読委員.
2018.05~2022.09, 日本ペインクリニック学会誌, 国内, 査読委員.
2017.05~2023.03, 慢性疼痛(日本慢性疼痛学会誌), 国内, 査読委員.
2015.07~2022.07, BioPsychoSocial Medicine, 国際, 編集委員.
2013.04~2016.03, Locomotive Pain Frontier, 国内, 編集顧問.
2008.12~2016.12, 心身医学, 国内, 編集委員.
学術論文等の審査
年度 | 外国語雑誌査読論文数 | 日本語雑誌査読論文数 | 国際会議録査読論文数 | 国内会議録査読論文数 | 合計 |
---|---|---|---|---|---|
2022年度 | 2 | 5 | 10 | 17 | |
2020年度 | 1 | 4 | 0 | 8 | 13 |
2019年度 | 2 | 3 | 0 | 4 | 9 |
2018年度 | 2 | 1 | 0 | 4 | 7 |
2017年度 | 1 | 2 | 0 | 8 | 11 |
2016年度 | 3 | 5 | 5 | 13 | |
2015年度 | 3 | 8 | 5 | 16 | |
2014年度 | 5 | 4 | 9 | ||
2013年度 | 4 | 3 | 0 | 10 | 17 |
2012年度 | 4 | 3 | 7 | ||
2011年度 | 2 | 2 | 4 | ||
2010年度 | 1 | 2 | 3 | ||
2008年度 | 0 | 3 | 0 | 0 | 3 |
2007年度 | 0 | 2 | 0 | 0 | 2 |
2006年度 | 0 | 2 | 0 | 0 | 2 |
2005年度 | 0 | 1 | 0 | 0 | 1 |
その他の研究活動
海外渡航状況, 海外での教育研究歴
University of Washington, Department of Rehabilitation Medicine, UnitedStatesofAmerica, 2008.07~2008.07.
National Institutes of Health (NIH), USA, UnitedStatesofAmerica, 1997.05~2002.05.
受賞
研究奨励賞, 日本消化器心身症研究会, 2011.10.
池見学術奨励賞, 九州大学心療内科同門会, 2003.11.
国際研究交流賞受賞, 金原一郎財団, 1996.01.
研究資金
科学研究費補助金の採択状況(文部科学省、日本学術振興会)
2021年度~2023年度, 基盤研究(C), 分担, 慢性疼痛に特異的な医療不信の介入阻害効果の検証と改善のための調査・介入研究.
2019年度~2022年度, 基盤研究(B), 代表, 慢性疼痛難治例の症例対照研究:中枢性感作に関する愛着・認知・情動とバイオマーカー.
2016年度~2019年度, 挑戦的萌芽研究, 分担, 慢性痛の脳画像によるクラスタリングの開発:Alexithymia vs神経症.
2016年度~2019年度, 基盤研究(C), 分担, 不信の4層モデルにもとづく難治性疼痛の医療者不信の把握と改善に向けた短期縦断研究.
2017年度~2020年度, 基盤研究(C), 分担, 幼少期の体験に注目したより有効な慢性疼痛に対する認知行動療法の開発.
2016年度~2018年度, 基盤研究(C), 分担, 一般住民における心理社会的因子・家族機能・社会脳と認知症の関連:久山町研究.
2014年度~2017年度, 基盤研究(C), 代表, 一般住民における心理特性・自律神経機能・失体感傾向と 慢性疾患の関連:久山町研究.
2013年度~2016年度, 基盤研究(C), 分担, 慢性疼痛における養育スタイルと生物心理社会的メカニズム.
2009年度~2011年度, 基盤研究(C), 代表, 生活習慣病の心身医学に関する疫学的研究―陽性感情や養育スタイルの影響―.
2005年度~2006年度, 基盤研究(C), 代表, 医学一般で使用可能な日本語痛み質問紙の開発および疼痛の中枢性制御に関する研究.
科学研究費補助金の採択状況(文部科学省、日本学術振興会以外)
2023年度~2023年度, 厚生労働科学研究費補助金 (厚生労働省), 分担, 痛みセンターを中心とした慢性疼痛診療システムの均てん化と診療データベースの活用による医療向上を目指す研究(課題番号:22FG2001)
.
.
2023年度~2026年度, 厚生労働科学研究費補助金 (厚生労働省), 分担, 種々の症状を呈する難治性疾患における中枢神経感作の役割 解明 と QOL 向上、社会啓発を目指した領域統合 多 施設共同疫学研究.
2023年度~2023年度, 厚生労働省 慢性疼痛診療システム均てん化等事業 九州, 代表, 慢性疼痛診療システム均てん化等事業 九州.
2022年度~2022年度, 厚生労働科学研究費補助金 (厚生労働省), 代表, 慢性疼痛診療システム普及・人材養成モデル事業.
2021年度~2021年度, 厚生労働科学研究費補助金 (厚生労働省), 代表, 慢性疼痛診療システム普及・人材養成モデル事業.
2020年度~2020年度, 厚生労働科学研究費補助金 (厚生労働省), 代表, 慢性疼痛診療システム普及・人材養成モデル事業.
2020年度~2022年度, 厚生労働科学研究費補助金 (厚生労働省), 分担, 慢性疼痛診療システムの均てん化と痛みセンター診療データベースの活用による医療向上を目指す研究.
2020年度~2022年度, 厚生労働科学研究費補助金 (厚生労働省), 分担, 種々の症状を呈する難治性疾患における中枢神経感作の役割の解明と患者ケアの向上を目指した複数疾患領域統合多施設共同疫学研究.
2018年度~2019年度, 厚生労働科学研究費補助金 (厚生労働省), 代表, 慢性疼痛診療体制構築モデル事業.
2018年度~2020年度, 厚生労働科学研究費補助金 (厚生労働省), 分担, 慢性の痛み診療・教育の基盤となるシステム構築に関する研究.
2017年度~2019年度, 厚生労働科学研究費補助金 (厚生労働省), 分担, 種々の症状を呈する難治性疾患における中枢神経感作の役割の解明とそれによる患者ケアの向上.
2015年度~2017年度, 厚生労働科学研究費補助金 (厚生労働省), 分担, 慢性の痛み診療・教育の基盤となるシステム構築に関する研究.
2013年度~2014年度, 厚生労働科学研究費補助金 (厚生労働省), 分担, 慢性の痛み診療の基盤となる情報の集約とより高度な診療の為の医療システム構築に関する研究.
2011年度~2013年度, 厚生労働科学研究費補助金 (厚生労働省), 分担, 「痛み」に関する教育と情報提供システムの構築に関する研究.
2011年度~2012年度, 厚生労働科学研究費補助金 (厚生労働省), 分担, 難治性疼痛の実態の解明と対応策の開発に関する研究.
2011年度~2013年度, 厚生労働科学研究費補助金 (厚生労働省), 分担, 情動的側面に着目した慢性疼痛の病態解明と診断・評価法の開発
.
.
2010年度~2010年度, 厚生労働科学研究費補助金 (厚生労働省), 分担, 難治性慢性疼痛の実態と病態の解明に関する研究.
2008年度~2010年度, 厚生労働科学研究費補助金 (厚生労働省), 連携, 心身症の実証的研究.
2005年度~2007年度, 厚生労働科学研究費補助金 (厚生労働省), 連携, 心身症の診断・治療ガイドラインに関する実証的研究.
競争的資金(受託研究を含む)の採択状況
2017年度~2019年度, 国立研究開発法人日本医療研究開発機構(AMED), 代表, 線維筋痛症と中枢性感作に関するトランスレーショナルリサーチ:精神神経免疫学的側面からの病態解明と評価法開発.
2015年度~2016年度, 国立研究開発法人日本医療研究開発機構(AMED), 代表, 慢性疼痛のトランスレーショナルリサーチ: 精神心理学的・神経免疫学的側面からの病態解明と評価法開発.
2014年度~2014年度, 厚生労働科学研究費補助金 (厚生労働省), 代表, 慢性疼痛のトランスレーショナルリサーチ: 精神心理学的・神経免疫学的側面からの病態解明と評価法開発 .
共同研究、受託研究(競争的資金を除く)の受入状況
2014.04~2015.03, 代表, 慢性疼痛のトランスレーショナルリサーチ ―精神心理学的・神経免疫学的側面からの病態解明と評価法開発―.
2013.04~2015.03, 分担, 厚生労働科学研究費補助金 慢性の痛み対策研究事業
慢性の痛み診療の基盤となる情報の集約とより高度な診療の為の医療システム構築に関する研究班
.
慢性の痛み診療の基盤となる情報の集約とより高度な診療の為の医療システム構築に関する研究班
.
2010.04~2013.03, 分担, 厚生労働科学研究費補助金 慢性の痛み対策研究事業 難治性疼痛の実態の解明と対応策の開発に関する研究班.
2009.04~2010.03, 代表, 慢性疼痛患者における上腹部症状と抑うつ・不安・破局化・失感情症との関係.
2008.04~2009.03, 代表, 慢性疼痛および消化器症状と失感情症に関する研究.
2008.04~2009.03, 代表, 上腹部症状と抑うつ・不安スコアとの関係
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2007.04~2008.03, 代表, 上腹部症状と抑うつ・不安スコアとの関係.
寄附金の受入状況
2009年度, エーザイ株式会社, 慢性疼痛患者における上腹部症状とと抑うつ・不安・破局化・失感情症との関係.
2008年度, エーザイ株式会社, 上腹部症状と抑うつ・不安スコアとの関係.
2007年度, エーザイ株式会社, 上腹部症状と抑うつ・不安スコア関係.
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九州大学病院
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