九州大学-研究者情報 [松島綾美 (准教授) 理学研究院化学部門]

松島綾美（まつしまあやみ）

データ更新日：2023.12.06

准教授　／　理学研究院化学部門有機・生物化学

総説, 論評, 解説, 書評, 報告書等

1.	松島綾美, 解説ビスフェノール類が環境ホルモンとして作用する機構を解明―コンピュータシミュレーションを駆使して見出した複雑な作用, 化学（化学同人）Vol. 77, No. 3, p 23-26 (2022), 2022.03.
2.	Tagawa, K., Suyama, K., Kesamaru, H., Masuya, T., Nose, T., Matsushima, A., Design and synthesis of a universal coactivator peptide binding to the estrogen receptor and Nurr1., 2021.03.
3.	Ayami Matsushima, A Novel Action of Endocrine-Disrupting Chemicals on Wildlife; DDT and Its Derivatives Have Remained in the Environment, International Journal of Molecular Sciences, 10.3390/ijms19051377, 2018.05, [URL], Huge numbers of chemicals are released uncontrolled into the environment and some of these chemicals induce unwanted biological effects, both on wildlife and humans. One class of these chemicals are endocrine-disrupting chemicals (EDCs), which are released even though EDCs can affect not only the functions of steroid hormones but also of various signaling molecules, including any ligand-mediated signal transduction pathways. Dichlorodiphenyltrichloroethane (DDT), a pesticide that is already banned, is one of the best-publicized EDCs and its metabolites have been considered to cause adverse effects on wildlife, even though the exact molecular mechanisms of the abnormalities it causes still remain obscure. Recently, an industrial raw material, bisphenol A (BPA), has attracted worldwide attention as an EDC because it induces developmental abnormalities even at low-dose exposures. DDT and BPA derivatives have structural similarities in their chemical features. In this short review, unclear points on the molecular mechanisms of adverse effects of DDT found on alligators are summarized from data in the literature, and recent experimental and molecular research on BPA derivatives is investigated to introduce novel perspectives on BPA derivatives. Especially, a recently developed BPA derivative, bisphenol C (BPC), is structurally similar to a DDT derivative called dichlorodiphenyldichloroethylene (DDE)..
4.	松島綾美、下東康幸、下東美樹, 昆虫の概日リズムペースメーカーペプチドホルモンPDF, 比較生理生化学, 18(3), 33-36 (1999), 2001.03.

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理学部・理学研究院