Kyushu University Academic Staff Educational and Research Activities Database
List of Papers
Arihiro Kano Last modified date:2021.08.04

Associate Professor / Department of Fundamental Organic Chemistry / Institute for Materials Chemistry and Engineering

1. Shindo, Mitsuru; Makigawa, Saki; Kodama, Kozue; Sugiyama, Hiromi; Matsumoto, Kenji; Iwata, Takayuki; Wasano, Naoya; Kano, Arihiro; Morita, Miyo Terao; Fujii, Yoshiharu, Design and chemical synthesis of root gravitropism inhibitors: Bridged analogues of ku-76 have more potent activity, Phytochemistry, 10.1016/j.phytochem.2020.112508, 179, 2020.11.
2. Shindo, Mitsuru; Makigawa, Saki; Matsumoto, Kenji; Iwata, Takayuki; Wasano, Naoya; Kano, Arihiro; Morita, Miyo Terao; Fujii, Yoshiharu, Essential structural features of (2Z,4E)-5-phenylpenta-2,4-dienoic acid for inhibition of root gravitropism, Phytochemistry, 10.1016/j.phytochem.2020.112287, 172, 2020.04.
3. Arihiro Kano, Takuma Iwasaki, Mitsuru Shindo, Bongkrekic acid facilitates glycolysis in cultured cells and induces cell death under low glucose conditions, Biochemistry and Biophysics Reports, 10.1016/j.bbrep.2019.100683, 20, 2019.12, Bongkrekic acid (BKA) inhibits adenine nucleotide translocator (ANT) and suppresses ADP/ATP exchange in the mitochondrial inner membrane. Previously, we demonstrated that BKA exhibited cytotoxic effects on 4T1 tumor cells, depending on the cell number in the culture, but not on NIH3T3 cells. However, the cause of this differential sensitivity was unelucidated. Here we demonstrate that BKA reduced the O2 consumption in both cell lines and increased the mitochondrial membrane potential, thereby facilitating glucose consumption. BKA reduced cellular ATP in 4T1 cells in a dose-dependent manner but not in NIH3T3 cells. The cellular ATP of 4T1 cells was decreased with a reduced glucose concentration in the media, but that of NIH3T3 cells remained constant. We also demonstrated that BKA-induced cell death in both cell lines in low glucose media; however, the susceptibility to the reduced glucose concentration was slightly higher in 4T1 cells, which may be attributed to the difference in the dependency on glycolysis as their energy source. These results indicate that 4T1 tumor cells rely heavily on glucose for energy production. Our data demonstrate that BKA disturbs ATP production in mitochondria and increases the susceptibility to a low glucose condition..
4. Mitsuru Shindo, Saki Makigawa, Kenji Matsumoto, Takayuki Iwata, Naoya Wasano, Arihiro Kano, Miyo Terao Morita, Yoshiharu Fujii, Essential structural features of (2Z,4E)-5-phenylpenta-2,4-dienoic acid for inhibition of root gravitropism, Phytochemistry, 10.1016/j.phytochem.2020.112287, 172, 2020.04, Previously, we found (2Z,4E)-5-phenylpenta-2,4-dienoic acid (ku-76) to be a selective inhibitor of root gravitropic bending of lettuce radicles at 5 μM, with no concomitant growth inhibition. Here, we describe a structure-activity relationship study of ku-76 to determine the essential structural features for the inhibitory activity. A series of ku-76 analogues was synthesized and the key features of ku-76 that are necessary for inhibition of lettuce root gravitropic bending were determined. The (2E,4E)-, (2Z,4Z)- (2E,4Z)- analogues were inactive, and 4,5-saturated and 4,5-alkynyl analogues also did not show inhibitory activity, demonstrating the importance of the (2Z,4E) diene unit. The aromatic ring was also crucial and could not be replaced with an alkyl chain. Derivatives in which the carboxylic acid was replaced with amides, alcohols, or esters were much less potent. These results suggest that the (2Z,4E)-diene, the carboxylic acid moiety, and the aromatic ring are essential for potent inhibitory activity against gravitropic bending..
5. Satoshi Fujita, Masaki Suyama, Kenji Matsumoto, Atsushi Yamamoto, Takenori Yamamoto, Yuka Hiroshima, Takayuki Iwata, ArihiroKano, Yasuo Shinohara, Mitsuru Shindo, Synthesis and evaluation of simplified functionalized bongkrekic acid analogs, Tetrahedron, 10.1016/j.tet.2018.01.018, 74, 9, 962-969, 2018.03, Bongkrekic acid (BKA) is a strong inhibitor of adenine nucleotide translocase (ANT), inducing inhibition of adenosine triphosphate synthesis. We designed and synthesized simplified benzene-ring-containing BKA analogs. The key reaction is the one-pot double Sonogashira reaction, which forms the main skeleton. The analogs were efficiently synthesized in 8–10 longest linear sequence steps. This synthetic method can be applied for the preparation of other analogs having different combinations of carbon chain lengths. Furthermore, the allyloxy group on the benzene ring can be easily replaced by other functional groups. Our preliminary biological evaluation based on mitochondrial inhibitory effects revealed the high potency of the analogs bearing the same carbon chain length as that of BKA. In particular, the prefunctionalized analogs are potential ANT inhibitors..
6. Arihiro Kano, Moses Kibunja Kamita, Takuma Iwasaki, Mitsuru Shindo, Bongkrekic Acid induces Selective Cytotoxicity in Tumor Cells, revealed by CCK-8, Evergreen, 04, 02/03, 23-27, 2017.09, Bongkrekic acid (BKA) is shown to inhibit adenine nucleotide translocator in the mitochondrial inner membrane, which is bifunctional and facilitates ATP/ADP exchange and permeability transition pore opening in mitochondria. We demonstrate that BKA reduces the viability of tumor cells depending on the cell number in the culture. This reduction was first demonstrated by Cell Counting Kit-8 (CCK-8), which indicates cellular viabilities based on the reduction of a formazan dye by cellular NADH. Reduced viability was not seen in normal cells. The glycolysis inhibitor 2-deoxyglucose enhanced the effect of BKA. BKA is thought to work as a mitochondrial inhibitor; however, its action is different from mitochondrial uncouplers. We further demonstrate that BKA suppresses autophagy induction, directing cells to death in nutrient-depleted conditions. Together these data indicate that BKA is a new type of mitochondrial inhibitor that does not disrupt the mitochondrial membrane and that is thus used together with a glycolysis inhibitor as an anticancer agent..
7. Moses Kamita, Mitsuru Shindo, Arihiro Kano, Macrophage Colony-Stimulating Factor mediates its Immunosuppressive Activity through the Emerging Myeloid Cells during Tumor Progression, Evergreen, 04, 02/03, 18-22, 2017.09, Mechanisms by which tumors evade immune surveillance remain to be addressed. In our previous study, we reported that murine mammary tumor (4T1) cells secrete immunosuppressive soluble factor(s), which was identified to be a 10-100 kDa protein. In the current study, we report that analysis of the proteins in the active fractions revealed the presence of macrophage colony-stimulating factor (M-CSF) as one of the suppressive factors secreted by 4T1 tumor cells. Although previously identified as a cytokine that regulates survival, proliferation, and differentiation of macrophages and monocytes, M-CSF has also been associated with tumor progression and metastasis. To date, the immunosuppressive activity of M-CSF is not well understood. To better understand the immunosuppressive activity of M-CSF, we studied the activity of recombinant murine M-CSF in splenocytes isolated from 4T1 tumor-bearing mice. Reduced levels of interferon-gamma (IFN-γ) by M-CSF were observed in a dose-dependent manner indicating suppressive activities of M-CSF on the T-cell activation. M-CSF reduces the secretion of IFN-γ without affecting its intracellular protein expression. The suppressive activity of M-CSF is dependent on the length of days after tumor inoculation as no activity was observed in splenocytes from one-week tumor-bearing mice. This phenomenon correlates with an increase in the number of myeloid cells in the spleen during tumor progression. The suppressive activity of M-CSF is thus thought to be mediated by the myeloid cells emerging during tumor growth..
8. Hiroshi Fukuda, 西川 慶祐, 福永 幸裕, 奥田 勝博, kenji matsumoto, Arihiro Kano, 新藤 充, Synthesis of fluorescent molecular probes based on cis-cinnamic acid and molecular imaging of lettuce roots, Tetrahedron, 10.1016/j.tet.2016.08.060, 72, 6492-6498, 2016.10, We synthesized azo dye- and fluorescence-labeled cis-cinnamic acid analogues possessing inhibitory activity against lettuce root growth and a trans-isomer without bioactivity as a control probe. The radicles incubated with the azo dye-labeled analogue were stained red, with their tips especially deeply dyed. The fluorescent images of the radicles incubated with each of these molecular probes depicted that the root cap was fluorescence-stained. However, images of the control radicles prepared by staining with
the trans-isomer fluorescent probe did not show emission at the root cap. These contrasts suggest specific localization of the cis-cinnamate analogue at the columella cells.
9. kenji matsumoto, 奥田 勝博, 福永 幸裕, Arihiro Kano, 新藤 充, Efficient Total Synthesis of Bongkrekic Acid and Apoptosis Inhibitory Activity of Its Analogues, CHEMISTRY-A EUROPEAN JOURNAL, 10.1002/chem.201501304, 21, 32, 11590-11602, 2015.08, Bongkrekic acid (BKA), isolated from the bacterium Burkholderia cocovenenans, is an inhibitor of adenine nucleotide translocator, which inhibits apoptosis, and is thus an important tool for the mechanistic investigation of apoptosis. An efficient total synthesis of BKA has been achieved by employing a three-component convergent strategy based on Kocienski–Julia olefination and Suzuki–Miyaura coupling. It is noteworthy that segmentB has been prepared as a new doubly functionalized coupling partner, which contributes to shortening of the number of steps. Torquoselective olefination with an ynolate has also been applied for the efficient
construction of an unsaturated ester. Furthermore, it is revealed that 1-methyl-2-azaadamantane N-oxyl is an excellent reagent for final oxidation to afford BKA in high yield. Based on the total synthesis, several BKA analogues were prepared for structure–activity relationship studies, which indicatedthat the carboxylic acid moieties were essential for the apoptosis inhibitory activity of BKA. More easily available BKA analogues with potent apoptosis inhibitory activity were also developed..
10. Arihiro Kano, Tumor cell secretion of soluble factor(s) for specific immunosuppression, SCIENTIFIC REPORTS, 10.1038/srep08913, 5, 2015.03.
11. Chen, Jie, Tian, Huayu, Dong, Xuan, Guo, Zhaopei, Jiao, Zixue, Li, Feifan, Arihiro Kano, Maruyama, Atsushi;, Chen, Xuesi, Effective Tumor Treatment by VEGF siRNA Complexed with Hydrophobic Poly(Amino Acid)-Modified Polyethylenimine, Chemistry Letters, 10.1002/mabi.201300211, 13, 10, 1438-1446, 2013.10.
12. Nishihara, M., Imato, K., Irie, A., Kanehara, T., Kano, A., Maruyama, A., Takahara, A., Otsuka, H., Reversibly Cross-linked Polymeric Micelles Formed by Autonomously Exchangeable Dynamic Covalent Bonds, Chemistry Letters, 42, 4, 377-379, 2013.04.
13. Kano, A., Taniwaki, Y., Nakamura, I., Shimada, N., Moriyama, K., Maruyama, A., Tumor delivery of Photofrin® by PLL-g-PEG for photodynamic therapy, J Control Release, 167, 32, 315-321, 2013.03.
14. Shimada, N., Kano, A., Maruyama, A., Design of UCST polymers for chilling capture of proteins, Chem Commun, 49, 5, 475-477, 2012.12.
15. Shimoda, A., Sawada, S., Kano, A., Maruyama, A., Moquin, A., Winnik, F.M., Akiyoshi, K., Dual crosslinked hydrogel nanoparticles by nanogel bottom-up method for sustained-release delivery, Colloids and surfaces. B, Biointerfaces, 99, 38-44, 2012.11.
16. Rui Moriyama, Junji Mochida, Asako Yamayoshi, Naohiko Shimada, Arihiro Kano, Atsushi Maruyama, Preparation of Cationic Comb-Type Copolymer Having Tetra-Alkylammonium Groups and its Interaction with DNA, Current Nanoscience,, 7, 6, 979-983, 2011.12.
17. Ohya, Y., Takeda, S., Shibata, Y., Ouchi, T., Kano, A., Iwata, T., Mochizuki, S., Taniwaki, Y., Maruyama, A, Evaluation of polyanion-coated biodegradable polymeric micelles as drug delivery vehicles, J Control Release, 155, 1, 104-110, 2011.10.
18. Tsutomu Ishihara, Arihiro Kano, Kentaro Obara, Minako Saito, Xuesi Chen, Tae Gwan Park,Toshihiro Akaike, Atsushi Maruyama, Nuclear localization and antisense effect of PNA internalized by ASGP-R-mediated endocytosis with protein/DNA conjugates, J. Control. Release, 155, 1, 34-39, 2011.10.
19. Naohiko Shimada, Haruka Ino, Kenji Maie, Miki Nakayama, Arihiro Kano, Atsushi Maruyama, Ureido-Derivatized Polymers Based on Both Poly(allylurea) and Poly(L-citrulline) Exhibit UCST-Type Phase Transition Behavior under Physiologically Relevant Conditions, Biomacromolecules,, 10, 12, 3418-3422, 2011.10.
20. Fujigaya, T., Yamamoto, Y., Kano, A., Maruyama, A., Nakashima, N., Enhanced cell uptake via non-covalent decollation of a single-walled carbon nanotube-DNA hybrid with polyethylene glycol-grafted poly(l-lysine) labeled with an Alexa-dye and its efficient uptake in a cancer cell, Nanoscale, 3, 10, 4352-4358, 2011.09.
21. Chen, J., Tian, H., Kano, A., Maruyama, A., Chen, X., and Park, T.G.,, In vitro and in vivo gene delivery using polyethylenimine-poly(hydroxyethyl glutamine) as a non-viral carrier, J. Controlled Release, 2011.08.
22. Rui Moriyama, Naohiko Shimada, Arihiro Kano, Atsushi Maruyama, The Role of Cationic Comb-type Copolymers in Chaperoning DNA Annealing., Biomaterials, 32, 30, 7671-7676, 2011.03.
23. Rui Moriyama, Naohiko Shimada, Arihiro Kano, Atsushi Maruyama, DNA assembly and re-assembly activated by cationic comb-type copolymer, Biomaterials, 32, 9, 2351-2358, 2011.03.
24. Naotaka Sonda, Masanori Hirano, Naohiko Shimada, Arihiro Kano, Satoru Kidoaki, and Atsushi Maruyama, Cationic Comb-type Copolymers Do Not Cause Collapse but Shrinkage of DNA Molecules, Chemistry letters, 40, 250-251, 2011.02.
25. Kano, A., Moriyama, K., Yamano, T., Nakamura, I., Shimada, N., and Maruyama, A., Grafting of poly(ethylene glycol) to poly-lysine augments its lifetime in blood circulation and accumulation in tumors without loss of the ability to associate with siRNA, J Control Release, 149, 2-7, 2011.02.
26. Shimada, N., Yamamoto, M., Kano, A., and Maruyama, A., Cationic Graft Copolymer as a DNA B-Z Transition Inducer: Effect of Copolymer Structure, Biomacromolecules, 11, 11, 3043-3048, 2010.11.
27. Chen, J., Tian, H., Guo, Z., Xia, J., Kano, A., Maruyama, A., Jing, X., and Chen, X., A highly efficient siRNA carrier of PBLG modified hyperbranched PEI, Macromol Biosci, 9, 12, 1247-53, 2009.12.
28. Shimada, N., Kano, A., and Maruyama, A., Design of cationic graft copolymers as a potential inducer of B-Z transition, Nucleic Acids Symp Ser, 53, 251-2, 2009.09.
29. Moriyama, R., Shimada, N., Kano, A., and Maruyama, A., Cationic comb-type copolymer as a nucleic acid chaperone for DNA quadruplex, Nucleic Acids Symp Ser, 53, Feb-61, 2009.09.
30. Thatiparti, T.R., Kano, A., Maruyama, A., and Takahara, A., Novel Silver-Loaded Semi-Interpenetrating Polymer Network Gel Films with Antibacterial Activity, Journal of Polymer Science Part a-Polymer Chemistry, 47, 19, 4950-62, 2009.08.
31. Morimoto, N., Tamada, J., Sawada, S., Shimada, N., Kano, A., Maruyama, A., and Akiyoshi, K., Interaction of Self-assembled Cationic Nanogels with Oligo-DNA and Function as Artificial Nucleic Acid Chaperone, Chemistry Letters, 38, 5, 496-7, 2009.04.
32. S. Mochizuki, A. Kano, N. Shimada, A. Maruyama, Uptake of enzymatically-digested hyaluronan by endothelial liver cells in vivo and in vitro, J. Biomater. Sci. Polymer Edn, 20, 83-97, 2009.01.
33. Reddy, T.T., Kano, A., Maruyama, A., Hadano, M., and Takahara, A., Synthesis and characterization of semi-interpenetrating polymer networks based on polyurethane and N-isopropylacrylamide for wound dressing, J Biomed Mater Res B Appl Biomater, 88, 1, 32-40, 2008.09.
34. A. Kano, T. Yamano, S. W. Choi, A. Maruyama, Polymer brush-stabilized polyplex for a siRNA carrier with long blood circulatory half-life, Advanced Materials Research, 47-50, 762-764, 2008.07.
35. A. Maruyama, L. Wu, N. Shimada and A. Kano, Kinetic Effect of Cationic Comb-type Copolymers on DNA Hybridization, Advanced Materials Research, 47-50, 1355-1358, 2008.07.
36. T. T. Reddy, A. Kano, A. Maruyama, M. Hadano and A. Takahara, Thermosensitive transparent semi-interpenetrating polymer networks for wound dressing and cell adhesion control, Biomacromolecules, 9(4), 1313-21., 2008.04.
37. H. Q. Zhang, S. Haga, M. Fukai, Y. Oikawa, H. Inoue, W. Ogawa, A. Kano, A. Maruyama, X. Y. Fu, S. Todo, S. Enosawa and M. Ozaki, Identification of de novo STAT3 target gene in liver regeneration, Hepatol Res, 38(4), 374-84., 2008.04.
38. S. W. Choi, A. Kano and A. Maruyama, Activation of DNA strand exchange by cationic comb-type copolymers: effect of cationic moieties of the copolymers, Nucleic Acids Res, 36(1), 342-51., 2008.01.
39. A. Moh, Y. Iwamoto, G. X. Chai, S. S. Zhang, A. Kano, D. D. Yang, W. Zhang, J. Wang, J. J. Jacoby, B. Gao, R. A. Flavell and X. Y. Fu, Role of STAT3 in liver regeneration: survival, DNA synthesis, inflammatory reaction and liver mass recovery, Lab Invest, 87(10), 1018-28., 2007.10.
40. N. Makita, S. W. Choi, A. Kano, A. Yamayoshi, T. Akaike and A. Maruyama, Effect of cationic comb-type copolymer on quadruplex folding of human telomeric DNA, Nucleosides Nucleotides Nucleic Acids, 26(8-9), 1115-9., 2007.08.
41. A. Sato, S. W. Choi, M. Hirai, A. Yamayoshi, R. Moriyama, T. Yamano, M. Takagi, A. Kano, A. Shimamoto and A. Maruyama, Polymer brush-stabilized polyplex for a siRNA carrier with long circulatory half-life, J Control Release, 122(3), 209-16., 2007.03.
42. Sato Y, Moriyama R, Choi SW, Kano A, Maruyama A, Spectroscopic investigation of cationic comb-type copolymers/DNA interaction: interpolyelectrolyte complex enhancement synchronized with DNA hybridization., Langmuir, 23(1):65-9, 2007.01.
43. N. Shimada, K. Muraki, T. Anai, A. Kano and A. Maruyama., Novel analysis for single nucleotide polymorphism using cationic comb-type copolymers, Nucleic Acids Symp Ser (Oxf), (51), 339-40., 2007.01.
44. L. Wu, N. Shimada, A. Kano and A. Maruyama, Effect of poly(L-lysine)-g-dextran copolymers on DNA hybridization, Nucleic Acids Symp Ser (Oxf), (51), 73-4., 2007.01.
45. Choi SW, Makita N, Inoue S, Lesoil C, Yamayoshi A, Kano A, Akaike T, Maruyama A., Cationic comb-type copolymers for boosting DNA-fueled nanomachines., Nano Lett., 7(1):172-8., 2006.12.
46. Yamashita A, Yui N, Ooya T, Kano A, Maruyama A, Akita H, Kogure K, Harashima H., Synthesis of a biocleavable polyrotaxane-plasmid DNA (pDNA) polyplex and its use for the rapid nonviral delivery of pDNA to cell nuclei., Nat Protoc., 1(6):2861-9, 2006.12.
47. S. Mochizuki, A. Kano, A. Yamayoshi, A. Maruyama, Hyaluronan conjugation of antigenic protein to modify immunogenic information, Science and Technology of Advanced Materials, 7 (7), 685-691, 2006.10.
48. Ooya, Tooru; Choi, Hak Soo; Yamashita, Atsushi; Yui, Nobuhiko; Sugaya, Yuko; Kano, Arihiro; Maruyama, Atsushi; Akita, Hidetaka; Ito, Rie; Kogure, Kentaro; Harashima, Hideyoshi, Biocleavable Polyrotaxane-Plasmid DNA Polyplex for Enhanced Gene Delivery, Journal of the American Chemical Society, 128(12), 3852-3853, 2006.03.
49. K. Takada, S. W. Choi, A. Yamayoshi, A. Kano and A. Maruyama, Structural effect of cationic copolymers on nucleic acid-chaperoning activity, Nucleic Acids Symp Ser (Oxf), (50), 27-8., 2006.01.
50. D. Ishii, K. Muraki, A. Kano, A. Yamayoshi and A. Maruyama, Single-base mismatch recognition using partially double-stranded probes having various lengths, Nucleic Acids Symp Ser (Oxf), (50), 325-6, 2006.01.
51. E. H. Chowdhury, A. Maruyama, A. Kano, M. Nagaoka, M. Kotaka, S. Hirose, M. Kunou and T. Akaike, pH-sensing nano-crystals of carbonate apatite: effects on intracellular delivery and release of DNA for efficient expression into mammalian cells, Gene, 376(1), 87-94, 2006.01.
52. Naohiko Shimada, Arihiro Kano, Atsushi Maruyama, B-Z DNA Transition Triggered by a Cationic Comb-Type Copolymer, Advanced Functional Materials, 19, 22, 3590-95, 2005.10.
53. S. W. Choi, K. Takada, J. Mochida, A. Yamayosh, A. Kano and A. Maruyama, The molecular structure effect of cationic comb-type copolymers on nucleic acid chaperone activity, Nucleic Acids Symp Ser (Oxf), (49), 329-30, 2005.01.
54. Hidetaka Torigoe, Atushi Maruyama, Satoshi Obika, Takeshi Imanishi, and Takuma Katayama, Synergistic Stabilization of Nucleic Acid Assembly by 2′-O,4′-C-Methylene-Bridged Nucleic Acid Modification and Additions of Comb-Type Cationic Copolymers, Biochemistry, 2005.01.
55. Zhang SS, Liu MG, Kano A, Zhang C, Fu XY, Barnstable CJ, STAT3 activation in response to growth factors or cytokines participates in retina precursor proliferation., Exp Eye Res, 81, 103-15, 2005.01.
56. N. Makita, A. Kano, A. Yamayoshi, T. Akaike and A. Maruyama, Modulation of highly ordered structures of human telomeric sequence by cationic copolymers, Nucleic Acids Symp Ser (Oxf), (49), 53-4, 2005.01.
57. Ushijima R., Sakaguchi N., Kano A., Maruyama A., Miyamoto Y., Sekimoto T., Yoneda Y., Ogino K., Tachibana T., Extracellular signal-dependent nuclear import of STAT3 is mediated by various importin alphas., Biochemical and Biophysical Research Communications, 10.1016/j.bbrc.2005.03.063, 330, 3, 880-886, 330, 880-886., 2005.01.
58. K. Hirata, D. Ishii, A. Kano, A. Yamayoshi, T. Akaike and A. Maruyama, Discrimination of single nucleotide polymorphisms by strand exchange assay using partially double-stranded probes, Nucleic Acids Symp Ser (Oxf), (49), 223-4, 2005.01.
59. K. Hirata, Y. Sato, A. Kano, T. Akaike and A. Maruyama, Nucleation-synchronized strand displacement for highly sensitive DNA analysis, Nucleic Acids Symp Ser (Oxf), (48), 267-8, 2004.01.
60. Kano A., Wolfgang M.J., Gao Q., Jacoby J., Chai G.X., Hansen W., Iwamoto Y, Pober J.S., Flavell R.A., Fu XY., Endothelial cells require STAT3 for protection against endotoxin-induced inflammation., J Exp Med., 198, 1517-1525, 2003.01.
61. Welte T., Zhang S.S., Wang T., Zhang Z., Hesslein D.G., Yin Z., Kano A., Iwamoto Y., Li E., Craft J.E., Bothwell A.L., Fikrig E., Koni P.A., Flavell R.A., Fu XY., STAT3 deletion during hematopoiesis causes Crohn's disease-like pathogenesis and lethality, Proc Natl Acad Sci U S A., 100, 1879-84, 2003.01.
62. Y. Sato, W. J. Kim, S. W. Choi, M. Saito, A. Kano, T. Akaike and A. Maruyama, Investigation of DNA strand exchange mechanisms mediated by cationic polymers, Nucleic Acids Res Suppl, (2), 59-60, 2002.01.
63. J. U. Park, T. Ishihara, A. Kano, T. Akaike and A. Maruyama, Preparation of dendritic graft copolymer consisting of poly-(L-lysine) and arabinogalactan as a hepatocyte specific DNA carrier, Prep Biochem Biotechnol, 29(4), 353-70., 1999.04.
64. Kano A., Haruyama T., Akaike T., Watanabe Y., IRF-1 is an essential mediator in IFN-gamma-induced cell cycle arrest and apoptosis of primary cultured hepatocytes. Biochem Biophys Res Commun., Biochem Biophys Res Commun., 121, 677-683., 1999.01.
65. A. Kano, Y. Watanabe, N. Takeda, S. Aizawa and T. Akaike, Analysis of IFN-gamma-induced cell cycle arrest and cell death in hepatocytes, J Biochem, 121(4), 677-83, 1997.04.