Kyushu University Academic Staff Educational and Research Activities Database
List of Reports
Wada Naohisa Last modified date:2021.11.02

Professor / Division of Interdisciplinary Dentistry / Department of Dental Science / Faculty of Dental Science

1. Histological examination on the biocompatibility of Calcipex..
2. Fibroblastic Cells Derived from Periapical Granuloma Have the Ability to Calcify.
3. H Maeda, Hashiguchi, I, H Nakamuta, Y Toriya, N Wada, A Akamine, Histological study of periapical tissue healing in the rat molar after retrofilling with various materials, JOURNAL OF ENDODONTICS, Vol.25, No.1, pp.38-42, 1999.01, We histologically examined the effects on the periapical tissue of various dental filling materials applied as retrofillings in rats and compared them with those of amalgam. The 4-META-TBB resin Superbond and the light-cured composite resin produced the least severe inflammatory reaction, with the greatest amount of new bone. In these specimens, regeneration of a part of the periodontal ligament was also observed. These results indicate that these materials might be very biocompatible and thus foster the natural regeneration of the periapical tissue..
4. The expression of osteoprotegerin (OPG)/osteoclastogenesis inhibitory factor (OCIF) in human periodontal ligament cells.
5. The effects of LPS on RANKL and OPG mRNA expression of human periodontal ligament fibroblastic cells.
6. Apoptosis of Epithelial Cells Proliferated in Human Periapical Lesions.
7. Establishment of human periodontal ligament cell lines and their characterization.
8. Influence of EMD and bFGF on mineralization in human periodontal ligament cell lines.
9. Establishment and Characterization of Human Periodontal Ligament Cell Lines with Multipotencies.
10. SEM images of root canal dentin irrigated with Smearclean : Comparison with ultrasonic irrigation.
11. Effects of root-end filling materials on the osteoblast-like differentiation of human periodontal ligament cells.
12. Matching between Dental Residents and External Facilities on a Postgraduate Clinical Training Program of Kyushu University Hospital.
13. Educational Environment Measure for the Residents in Postgraduate Clinical Training, Kyushu University Hospital.
14. A multipotent hPDL cell line promotes neurocytic differentiation and migration.
15. MTA induces osteoblastic differentiation of human periodontal ligament cells.
16. SEM images of root canal dentin irrigated with EDTA and NaOCl : Comparison with ultrasonic irrigation.
17. The Effects of Mineral Trioxide Aggregate (MTA) on Human Periodontal Ligament Cells
Since mineral trioxide aggregate (MTA) was developed and reported as an endodontic restoration in the early 1990s, it has been shown that this material offers excellent biocompatibility with the hard tissue on its surface when used for direct pulp capping, furcal repair, repair for root perforation, root-end filling, and apexification, and for inducing tissue regeneration around the filled portion. However, the effects of MTA on the periodontal ligament tissue remain unclear, so this study evaluated the effects of MTA on the attachment, proliferation, and differentiation of human periodonta....
18. Biocompatibility of resin-based sealers : Comparison of Superbond sealer with AH Plus.
19. Atsushi Tomokiyo, Naohisa Wada, Hidefumi Maeda, Periodontal Ligament Stem Cells
Regenerative Potency in Periodontium
, Stem cells and development, 10.1089/scd.2019.0031, 2019.08, Periodontium is consisted of root cementum, bone lining the tooth socket, gingiva facing the tooth, and periodontal ligament (PDL). Its primary functions are support of the tooth and protection of tooth, nerve, and blood vessels from injury by mechanical loading. Severe periodontitis induces the destruction of periodontium and results in a significant cause of tooth loss among adults. Unfortunately, conventional therapies such as scaling and root planning are often only palliative. Therefore, the ultimate goal of the treatment for periodontitis is to restore disrupted periodontium to its original shape and function. Tissue engineering refers to the process of combining cells, scaffolds, and signaling molecules for the production of functional tissues to restore, maintain, and improve damaged organs. The discovery of periodontal ligament stem cells (PDLSCs) highlighted the possibility for development of tissue engineering technology-based therapeutics for disrupted periodontium. PDLSCs are a kind of somatic stem cells that show potential to differentiate into multiple cell types and undergo robust clonal self-renewal. Therefore, PDLSCs are considered a highly promising stem cell population for regenerative therapy in periodontium; however, their rarity prevents the progression of basic and clinical researches. In this review, we summarize recent research advancement and accumulated information regarding the self-renewal capacity, multipotency, and immunomodulatory effect of PDLSCs, as well as their contribution to repair and regeneration of periodontium and other tissues. We also discuss the possibility of PDLSCs for clinical application of regenerative medicine and provide an outline of the genetic approaches to overcome the issue about the rarity of PDLSCs..
20. Hiroko Tsuda, Naohisa Wada, S. Ando, Practical considerations for effective oral appliance use in the treatment of obstructive sleep apnea: a clinical review. , 2017.06.
21. Atsushi Tomokiyo, Kim Hynes, Naohisa Wada, Stan Gronthos, P. Mark Bartold, Is there a role for neural crest stem cells in periodontal regeneration?, 2015.08.
22. Naohisa Wada, Atsushi Tomokiyo, Stan Gronthos, P. Mark Bartold, Immunomodulatory properties of PDLSC and relevance to periodontal regeneration., 2015.08.
23. Hidefumi Maeda, Atsushi Tomokiyo, Naohisa Wada, Koori Katsuaki, G Kawachi, Akifumi Akamine, Regeneration of the periodontium for preservation of the damaged tooth., 2014.10.
24. Naohisa wada, Stan Gronthos, P.Mark Bartold, Immunomodulatory Effects of Stem Cells, Periodontol 2000. 63(1):198-216., 63(1):198-216, 2013.10.
25. Hidefumi Maeda, naohisa wada, Atsushi Tomokiyo, Monnouchi Satoshi, Akifumi Akamine, Prospective Potency of TGF-β1 on Maintenance and Regeneration of Periodontal Tissue., Int Rev Cell Mol Biol. 304:283-367, 2013.06.
26. Hidefumi Maeda, Fujii Shinsuke, Atsushi Tomokiyo, naohisa wada, Akifumi Akamine, Periodontal Tissue Engineering: Defining the Triad, Int J Oral Maxillofac Implants. 28(6):e461-471., 28(6):e461-471, 2013.06.
27. Maeda H, Tomokiyo A, Fujii S, Wada N, Akamine A, Promise of periodontal ligament stem cells in regeneration of periodontium, Stem Cell Res Ther. 2:33., 2011.08.