Kyushu University Academic Staff Educational and Research Activities Database
List of Reports
Zhou Wu Last modified date:2021.11.26

Associate Professor / Department of Aging Science and Pharmacology / Department of Dental Science / Faculty of Dental Science

1. Hiroshi Nakanishi , Saori Nonaka , Zhou Wu., Microglial cathepsin B and Porphyromonas gingivalis gingipains as potential therapeutic targets for sporadic Alzheimer's disease., CNS Neurol Disord Drug Targets., 10.2174/1871527319666200708125130, Online ahead of print., 2020.07.
2. Xu Yan;Zhou Wu;Biyao Wang;Tianhao Yu; Yue Hu; Sijian Wang;Chunfu Deng; Baohong Zhao; Hiroshi Nakanishi and Xinwen Zhan, Involvement of Cathepsins in Innate and Adaptive Immune Responses in Periodontitis, Evidence-Based Complementary and Alternative Medicine,, 2020.03, Periodontitis is an infectious disease whereby the chronic inflammatory process of the periodontium stimulated by bacterial products induces specific host cell responses. The activation of the host cell immune system upregulates the production of inflammatorymediators,comprisingcytokinesandproteolyticenzymes,whichcontributetoinflammationandbonedestruction.Ithasbeenwellknownthatperiodontitisisrelatedtosystemicinflammationwhichlinkstonumeroussystemicdiseases,includingdiabetesandarteriosclerosis.Furthermore,periodontitishasbeenreportedinassociationwithneurodegenerativediseasessuchasAlzheimer’sdisease(AD)inthebrain.Regardingimmuneresponsesandinflammation,cathepsinB(CatB)playspivotalrolefortheinductionofIL-1β,cathepsinK-(CatK-)dependentactivetoll-likereceptor9(TLR9)signaling,andcathepsinS(CatS)which involves in regulating both TLR signaling and maturation of the MHC class II complex. Notably, both the production and proteolytic activities of cathepsins are upregulated in chronic inflammatory diseases, including periodontitis. In the present review, we focus on the roles of cathepsins in the innate and adaptive immune responses within periodontitis. We believe that understandingtherolesofcathepsinsintheimmuneresponsesinperiodontitiswouldhelptoelucidatethetherapeuticstrategies of periodontitis, thus benefit for reduction of systemic diseases as well as neurodegenerative diseases in the global aging society..
3. Wu Z, Yu J, Zhu A, Nakanishi H, Nutrients, Microglia Aging, and Brain Aging, Oxid Med Cell Longev, 2016:7498528, 2016.06.
4. Wu Z, Hiroshi Nakanishi, Lessons from Microglia Aging for the Link between Inflammatory Bone Disorders and Alzheimer's Disease., J Immunol Res, 2015.05.
5. Wu Z, Hiroshi Nakanishi, Connection between periodontitis and Alzheimer's disease: possible roles of microglia and leptomeningeal cells, J Pharmacol Sci., 2014.08.
6. Wu Z, Zhu A, Wu S, Hiroshi Nakanishi, Preventing and Reversing “Microglia-Aging” by Nature Elements for Slow Brain- Aging , J Neurological Disorders. 2013 2:1:1000143, 2013.12.
7. Hiroshi Nakanishi, Yoshinori Hayashi, Wu Z, The role of microglial mtDNA damage in age-dependent prolonged LPS-induced sickness behavior., Neuron Glia Biol. 216:133-42, 2011.02.
8. Nakanishi H. and Wu Z. , Microglia-aging: Roles of microglial
lysosome- and mitochondria-deroved reactive oxygen species in brain aging. Behav. Brain Res.
, Behav. Brain Res. Behav Brain Res., 19; 201(1):1-7., 2009.07.
9. Wu Z, Nakanishi H. , Phosphatidylserine-containing liposomes: potential pharmacological interventions against inflammatory and immune diseases through the production of prostaglandin E(2) after uptake by myeloid derived phagocytes., Arch Immunol Ther Exp , 2011.01.