Kyushu University Academic Staff Educational and Research Activities Database
List of Papers
Takeshi Mori Last modified date:2022.06.28

Associate Professor / laboratory of functional organization chemistry / Department of Applied Chemistry / Faculty of Engineering


Papers
1. K. Sasaki, M. Harada, T. Yoshikawa, H. Tagawa, Y. Harada, Y. Yonemitsu, T. Ryujin, A. Kishimura, T. Mori, Y. Katayama, Fc-binding antibody-recruiting molecules targeting prostate-specific membrane antigen: defucosylation of antibody for efficacy improvement,, ChemBioChem, 22, 496-500, 2021.02.
2. K. Sasaki, K. Muguruma, R. Osawa, A. Fukuda, A. Taniguchi, A. Kishimura, Y. Hayashi, T. Mori, Y. Katayama, Synthesis and biological evaluation of a monocyclic Fc-binding antibody-recruiting molecule for cancer immunotherapy, RSC Med. Chem., 12, 406-409, 2021.02.
3. Y. Mu, Y. Kinashi, J. Li, T. Yoshikawa, A. Kishimura, M. Tanaka, T. Matsui, T. Mori, K. Hase, Y. Katayama, Polyvinyl butyrate nanoparticles as butyrate donors for colitis treatment, ACS Applied Bio Mater., 4, 2335, 2021.01.
4. Y. Liu, T. Maruyama, Biplab KC, T. Mori, Y. Katayama, A. Kishimura, Inducible Dynamic Behavior of Polyion Complex Vesicles by Disrupting Charge Balance, Chem. Lett., 50, 1034-1037, 2021.04.
5. C. W. Kim, R. Toita, J.-H. Kang, T. Mori, A. Kishimura, Y. Katayama, Protein kinase C α-responsive gene carrier for cancer-specific transgene expression and cancer therapy, ACS Biomater. Sci. Eng., 7, 2530-2537, 2021.06.
6. J. Li, Y. Mu, Y. Liu, A. Kishimura, T. Mori, Y. Katayama, Effect of size and loading of retinoic acid in polyvinyl butyrate nanoparticles on amelioration of colitis, polymers, 13, 1472, 2021.08.
7. H. Feng, J.-H. Kang, S. Qi, A. Kishimura, T. Mori, Y. Katayama, Preparation of a PEGylated liposome that co-encapsulates L-arginine and doxorubicin to achieve a synergistic anticancer effect, RSC Adv., 11, 34101-34106, 2022.06.
8. S. Li, K. Yakabe, K. Zai, Y. Liu, A. Kishimura, K. Hase, Y.-G. Kim, T. Mori, Y. Katayama, Specific adsorption of a β-lactam antibiotic in vivo by an anion-exchange resin for protection of the intestinal microbiota, Biomater. Sci., 9, 7219-7227, 2021.11.
9. K. Tanito, Y. Oshiro, H. Tagawa, A. Kishimura, T. Mori, Y. Katayama, Comparative evaluation of natural killer cell-mediated cell killing assay based on the leakage of an endogenous enzyme or a pre-loaded fluorophore, Anal. Sci., 37, 1571-1575, 2021.12.
10. T. Ryujin, T. Shimizu, R. Miyahara, D. Asai, R. Shimazui, T. Yoshikawa, A. Kishimura, T. Mori, T. Ishida, Y. Katayama, Blood retention and antigenicity of polycarboxybetaine-modified liposomes, Int. J. Pharm. , 586, 119521, 2020.04.
11. K. Yuzuriha, A. Yoshida, S. Li, A. Kishimura, T. Mori, Y. Katayama, Synthesis of peptide conjugates with vitamins for induction of antigen-specific immunotolerance, J. Peptide Sci., 26, e3275, 2020.06.
12. K. Yuzuriha, K. Yakabe, H. Nagai, S. Li, T. Zendo, K. Zai, A. Kishimura, K. Hase, Y-G Kim, T. Mori, Y. Katayama, Protection of gut microbiome from antibiotics: development of a vancomycin-specific adsorbent with high adsorption capacity, Biosci. Microbio. Food Health, 39, 128-136, 2020.06, 腸内細菌叢を破壊することが知られる抗生物質(バンコマイシン)を腸間で特異的に吸着する粒子を開発し、実際に、腸内細菌を保護することを示した。また細菌叢の破壊に由来する感染症からマウスを保護することができた。.
13. K. Noguchi, T. Shimomura, Y. Ohuchi, M. Ishiyama, M. Shiga, T. Mori, Y. Katayama, Y. Ueno, Β-galactosidase-catalyzed fluorescent reporter labeling of living cells for sensitive detection of cell surface antigens, Bioconjugate Chem., 31, 1740-1744, 2020.05, beta-ガラクトシダーゼを酵素として、一細胞の抗原を高感度に増感検出する方法(蛍光がターンオンし、細胞に共有結合して脱離しない)の開発に初めて成功した。.
14. H. Feng, L. T. Nam, T. Yoshikawa, A. Kishimura, T. Mori, Y. Katayama, Effect of an endothelin B receptor agonist on the tumor accumulation of nanocarriers, Biol. Pharm. Bull., 43, 1301-1305, 2020.06.
15. Y. Mu, J. Li, J.-H. Kang, H. Eto, K. Zai, A. Kishimura, F. Hyodo, T. Mori, Y. Katayama, A lipid-based nanocarrier containing active vitamin D3 ameliorates NASH in mice via direct and intestine-mediated effects on liver inflammation, Biol. Pharm. Bull., 43, 1413-1420, 2020.06.
16. Md. Z. Hosain, F. Hyodo, T. Mori, K. Takahashi, Y. Nagao, H. Eto, T. Nakaji, M. Murata, T. Akaboshi, M. Matsuo, Y. Katayama, Development of a novel molecular probe for the detection of liver mitochondrial redox metabolism, Sci. Rep, 10, 16489, 2020.08.
17. H. Feng, A. Kishimura, T. Mori, Y. Katayama, Evaluation of Synergistic Effect of L-Arginine on the Anticancer Activity of Doxorubicin by Using Co-culture System, Anal Sci, 36, 1279-1283, 2020.09.
18. X. Sun, R. Tokunaga, Y. Nagai, R. Miyahara, A. Kishimura, S. Kawakami, Y. Katayama, T. Mori, Ligand design for specific MHC class I molecules on the cell surface, Biochemistry, 59, 4646, 2020.10.
19. Y. Mu, Y. Kinashi, A. Kishimura, T. Mori, K. Hase, Y. Katayama, Effect of polyvinyl butyrate nanoparticles incorporated with immune suppressing vitamins on alteration of population of intestinal immune cells, Prog. Nat. Sci. Mater. Int., 30, 707-70, 2020.12.
20. K. Sasaki, M. Harada, Y. Miyashita, H. Tagawa, A. Kishimura, T. Mori, Y. Katayama,, Fc-binding antibody-recruiting molecules exploit endogenous antibodies for anti-tumor immune responses, Chem. Sci., 11, 3208-3214, 2020.03, 抗体医薬を低分子化合物で置き換えることを企図し、がん細胞と内在性の抗体を架橋する低分子を開発した。この分子は、in vitro, in vivoで抗がん活性を示した。.
21. H. Tagawa, K. Maruyama, K. Sasaki, N. Konoue, A. Kishimura, M. Kanai, T. Mori, K. Oisaki, Y. Katayama, Induction of ADCC by folic acid-mAb conjugate prepared by tryptophan-selective reaction toward folate-receptor-positive cancer cells, RSC Adv., 10, 16727-16731, 2020.03.
22. T. Yoshikawa, K. Q. Phan, H. Tagawa, K. Sasaki, H. Feng, A. Kishimura, T. Mori, Y. Katayama, Modification of nitric oxide donors onto a monoclonal antibody boosts accumulation in solid tumors, Int. J. Pharm., 583, 119352, 2020.03.
23. T. Nobori, M. Kawamura, R. Yoshida, T. Joichi, K. Kamino, A. Kishimura, E. Baba, T. Mori, Y. Katayama,, Fluorescence Signal Amplification by Using β-Galactosidase for Flow Cytometry; Advantages of an Endogenous Activity-free Enzyme,, Anal. Chem., 92, 3069-3076, 2020.01.
24. T. Mori, Y. Katayama, Signal amplification in flow cytometry for cell surface antigen analysis, J. Biochem., 166, 205-212, 2019.12.
25. D. Asai, T. Fukuda, K. Morokuma, D. Funamoto, Y. Yamaguchi, T. Mori, Y. Katayama, K. Shibayama, H. Nakashima, Injectable polypeptide hydrogel depot system for assessment of the immuneresponse-inducing efficacy of sustained antigen release alone, Macromol. Biosci., 19, e1900167, 2019.10.
26. T. Mori, A. Kishimura, Y. Katayama, , Nanoparticle-Based Drug and Gene Delivery for Tumor Targeting, Material Matters, 14.3, 2019.10.
27. W. Hatanaka, H. Takeuchi, M. Koga, T. Ryujin, A. Kishimura, Y. Katayama, S. Tsukiji, T. Mori, Synthesis of Transmembrane Molecules by Click Chemistry, Chem Lett, 48, 433-436, 2019.06.
28. K. Zai, N. Ishihara, H. Oguchi, M. Hirota, T. Mori, K. Hase, Y. Katayama, Regulation of inflammatory response of macrophages and induction of regulatory T cells by using retinoic acid-loaded nanostructured lipid carrier, Anal. Sci., 30, 1-11, 2019.06.
29. H. Nagai, W. Hatanaka, M. Matsuda, A. Kishimura, Y. Katayama, T. Mori, Folate receptor-specific cell-cell adhesion by using a folate-modified peptide-based anchor, J. Biomater. Sci. Polym. Ed., 30, 983-993, 2019.06.
30. T. Yoshikawa, Y. Mori, H. Feng, K. Q. Phan, A. Kishimura, J.-H. Kang, T. Mori, Y. Katayama, Rapid and continuous accumulation of nitric oxide-releasing liposomes in tumors to augment the enhanced permeability and retention (EPR) effect, Int. J. Pharm., 565, 481-487, 2019.06.
31. K. Zai, K. Yuzuriha, A. Kishimura, T. Mori, Y. Katayama, Preparation of complexes between ovalbumin nanoparticles and retinoic acid for efficient induction of tolerogenic dendritic cells, Anal. Sci., 34, 1243-1248, 2018.12.
32. K. Zai, M. Hirota, T. Yamada, N. Ishihara, T. Mori, A. Kishimura, K. Suzuki, K. Hase, Y. Katayama, Therapeutic effect of vitamin D3-containing nanostructured lipid carriers on inflammatory bowel disease, J. Controlled Release, 286, 94-102, 2018.11.
33. H. Sato, Y. Miyashita, K. Sasaki, A. Kishimura, T. Mori, Y. Katayama, Non-covalent Coating of Liposome Surface with IgG through Its Constant Region, Chem. Lett., 47, 770-772, 2018.10.
34. K. Sasaki, Y. Miyashita, D. Asai, D. Funamoto, K. Sato, Y. Yamaguchi, Y. Mishima, T. Iino, S. Takaishi, J. Nagano, A. Kishimura, T. Mori, Y. Katayama, A Peptide Inhibitor of Antibody-Dependent Cell-Mediated Cytotoxicity against EGFR/Folate Receptor-α Double Positive Cells, Med. Chem. Commun., 9, 783-788, 2018.03.
35. T. Nobori, K. Tosaka, A. Kawamura, T. Joichi, K. Kamino, A. Kishimura, E. Baba, T. Mori, Y. Katayama, Alkaline Phosphatase-Catalyzed Amplification of a Fluorescence Signal for Flow Cytometry, Anal. Chem., 90, 1059-1062, 2018.02, フローサイトメトリーを高感度化するために、酵素反応を利用して細胞に対する蛍光標識の強度を増強させる方法を開発した.
36. E. Nakahei, K. Takehara, H. Sato, K. Zai, A. Kishimura, T. Mori, Y. Katayama, A Dual Alkylated Peptide-ligand Enhances Affinity to Human Serum Albumin, Anal. Sci., 34, 501-504, 2018.01.
37. H. Sato, E. Nakhaei, Elnaz, T. Kawano, M. Murata, A. Kishimura, T. Mori, Y. Katayama, Ligand-mediated Coating of Liposomes with Human Serum Albumin, Langmuir, 34, 2324-2331, 2018.01.
38. E. Nakhaei, C. W. Kim, D. Funamoto, H. Sato, Y. Nakamura, A. Kishimura, T. Mori, Y. Katayama, Ligand design for cancer imaging with long blood circulation and enhanced accumulation ability in tumors, Med. Chem. Commun., 8, 1190-1195, 2017.09.
39. Y. Tahara, T. Yoshikawa, H. Sato, Y. Mori, Z. Hosain, A. Kishimura, T. Mori, Y. Katayama, Encapsulation of a nitric oxide-donor into a liposome to boost the enhanced permeation and retention (EPR) effect, Med. Chem. Commun., 8, 415-421, 2017.08.
40. A. Tsuchiya, J.-H. Kang, T. Mori, Y. Naritomi, S. Kushio, T. Niidome, K. Tachibana, Y. Takahashi, Y. Negishi, Y. Oda, R. Suzuki, K. Maruyama, Y. Katayama, Efficient delivery of signal-responsive gene carriers for disease-specific gene expression via bubble liposomes and sonoporation, , Coll. Surf. B: Biointerfaces, 160, 60-64, 2017.06.
41. E. Nakhaei, C. W. Kim, D. Funamoto, H. Sato, Akihiro Kishimura, Takeshi Mori, Yoshiki Katayama, Ligand design for cancer imaging with long blood circulation and enhanced accumulation ability in tumors, Med. Chem. Comm., 2017.05.
42. Y. Nakamura, H. Sato, T. Nobori, H. Matsumoto, S. Toyama, T. Shuno, Akihiro Kishimura, Takeshi Mori, Yoshiki Katayama, Modification of ligands for serum albumin on polyethyleneimine to stabilize polyplexes in gene delivery, J. Biomater. Sci. Polym. Ed., 2017.05.
43. C. Li, M. Takeo, M. Matsuda, H. Nagai, S. Xizheng, W. Hatanaka, Akihiro Kishimura, Yoshiki Katayama, Takeshi Mori, Facilitating the presentation of antigen peptides on dendritic cells for cancer immunotherapy using a polymer-based synthetic receptor, Med. Chem. Commun., 2017.05.
44. W. Hatanaka, M. Kawaguchi, X. Sun, Y. Nagao, H. Ohshima, M. Hashida, Y. Higuchi, Akihiro Kishimura, Yoshiki Katayama, Takeshi Mori, Use of membrane potential to achieve transmembrane modification with an artificial receptor, Bioconjugate Chem., 28, 296, 2017.03, 細胞膜に膜貫通した状態で分子を修飾する方法を世界ではじめて開発した。.
45. Takeshi Mori, Yoshiki Katayama, Akihiro Kishimura, Y. Tahara, Encapsulation of a nitric oxide-donor into a liposome to boost the enhanced permeation and retention (EPR) effect, Med. Chem. Commun, 8, 415, 2017.01.
46. K. Naoyama, Takeshi Mori, Yoshiki Katayama, Akihiro Kishimura, Fabrication of Dendrimer‐Based Polyion Complex Submicrometer‐Scaled Structures with Enhanced Stability under Physiological Conditions, Macromol. Rapid Commun., 37, 1087, 2016.05.
47. P. Kumar, M. Z. Hosain, J.-H. Kang, M. Takeo, Akihiro Kishimura, Takeshi Mori, Yoshiki Katayama, Suppression of atopic dermatitis in mice model by reducing inflammation utilizing phosphatidylserine-coated biodegradable microparticles, J. Biomater. Sci. Polym. Ed., 26, 1465, 2015.11.
48. E. K. Lee, C. W. Kim, H. Kawanami, Akihiro Kishimura, T. Niidome, Takeshi Mori, Yoshiki Katayama, Utilization of a PNA-peptide Conjugate to Induce a Cancer Protease-Responsive RNAi Effect, RSC Adv., 5, 85816, 2015.11, PNA-peptideコンジュゲートにより、腫瘍において選択的にRNAiを生じるシステムを開発した。腫瘍で高活性化しているcathepsin Bを標的にしたシステムであるが、一般性が高く、望みのプロテアーゼに対して設計可能である。.
49. S. Sugimoto, R. Moriyama, Takeshi Mori, Y. Iwasaki, Surface engineering of macrophages with nucleic acid aptamers for circulating tumor cell capture, Chem. Commun., 51, 17428, 2015.11.
50. K. Li, H. Sato, C.W. Kim, Y. Nakamura, G.X. Zhao, D. Funamoto, T. Nobori, Akihiro Kishimura, Takeshi Mori, Yoshiki Katayama, Tumor accumulation of protein kinase-responsive gene carrier/DNA polyplex stabilized by alkanethiol for intravenous injection, J. Biomater. Sci. Polym. Ed., 26, 657, 2015.07.
51. Kai Li, Hikari Sato, Chan Woo Kim, Yuta Nakamura, Guo Xi Zhao, Daiki Funamoto, Takanobu Nobori, Akihiro Kishimura, Takeshi Mori, Yoshiki Katayama, Tumor accumulation of protein kinase-responsive gene carrier/DNA polyplex stabilized by alkanethiol for intravenous injection, Journal of Biomaterials Science, Polymer Edition, 10.1080/09205063.2015.1054922, 26, 11, 657-668, 2015.07, We synthesized polymeric gene carriers consisting of poly-L-lysine (PLL) main chain modified both with substrate peptide for protein kinase C (PKC) and alkanethiol (pentadecanethiol). Due to the grafted substrate peptide, the polyplex prepared from these carriers is expected to show gene expression triggered by the phosphorylation of the peptide by intracellular PKC. The modified alkanethiol on the main chain stabilized the polyplex both via disulfide crosslinking and hydrophobic interaction. The polyplex found to show gene expression in vitro when the alkanethiol content in the main chain was enough low (4-mol%-modification of PLLs ε-amine group) to minimize cytotoxic effect. Even though the content of alkanethiol is low, the polyplex had significant stability in a model serum solution and showed longer blood circulation in vivo. The polyplex clearly accumulated in tumor after intravenous injection..
52. Masafumi Takeo, Cuicui Li, Masayoshi Matsuda, Hiroko Nagai, Wataru Hatanaka, Tatsuhiro Yamamoto, Akihiro Kishimura, Takeshi Mori, Yoshiki Katayama, Optimum design of amphiphilic polymers bearing hydrophobic groups for both cell surface ligand presentation and intercellular cross-linking, Journal of Biomaterials Science, Polymer Edition, 10.1080/09205063.2015.1007414, 26, 6, 353-368, 2015.04, Amphiphilic polymers bearing hydrophobic alkyl groups are expected to be applicable for both ligand presentation on the cell surface and intercellular crosslinking. To explore the optimum design for each application, we synthesized eight different acyl-modified dextrans with varying molecular weight, alkyl length, and alkyl modification degree. We found that the behenate-modified polymers retained on the cell surface longer than the palmitate-modified ones. Since the polymers were also modified with biotin, streptavidin can be presented on the cell surface through biotin-streptavidin recognition. The duration of streptavidin on the cell surface is longer in the behenate-modified polymer than the palmitate-modified one. As for the intercellular crosslinking, the palmitate-modified polymers were more efficient than the behenate-modified polymers. The findings in this research will be helpful to design the acyl-modified polymers for the cell surface engineering..
53. M. Takeo, C. Li, M. Matsuda, H. Nagai, W. Hatanaka, T. Yamamoto, Akihiro Kishimura, Takeshi Mori, Yoshiki Katayama, Optimum design of amphiphilic polymers bearing hydrophobic groups both for cell surface ligand presentation and intercellular cross-linking, J. Biomater. Sci. Polym. Ed., 26, 353, 2015.03.
54. D Funamoto, D Asai, CW Kim, Y Nakamura, EK Lee, T Niidome, Takeshi Mori, Yoshiki Katayama, Tandemly Repeated Peptide for Cancer-specific Gene Carrier Prepared by Native Chemical Ligation, Chem Lett, 44, 474-476, 2015.02.
55. D. Funamoto, D. Asai, K. Sato, Y. Yamaguchi, C. W. Kim, H. Sato, E. Nakhaei, S. Matsumoto, T. Yoshikawa, K. Sasaki, T. Yamamoto, Akihiro Kishimura, Takeshi Mori, Yoshiki Katayama, Antibody Internalization into Living Cell via Crosslinker-mediated Endocytosis, Chem. Lett., 44, 468, 2015.02.
56. Daiki Funamoto, Daisuke Asai, Kazuki Sato, Yoko Yamaguchi, Chan Woo Kim, Hikari Sato, Elnaz Nakhaei, Shingo Matsumoto, Takuma Yoshikawa, Koichi Sasaki, Tatsuhiro Yamamoto, Akihiro Kishimura, Takeshi Mori, Yoshiki Katayama, Antibody internalization into living cells via crosslinker-mediated endocytosis, Chemistry Letters, 10.1246/cl.141157, 44, 4, 468-470, 2015.01, We reported here an alternative strategy of antibody internalization by crosslinker-mediated endocytosis. This cross-linker consists of IgG binding peptide and folic acid as cancer targeting ligands toward the folate receptor, which highly expresses in many cancer cells surface. This crosslinker successfully facilitated antibody internalization into cancer cell by the folate receptor-mediated endocytosis..
57. Shunsuke Sugimoto, Rui Moriyama, Takeshi Mori, Yasuhiko Iwasaki, Surface engineering of macrophages with nucleic acid aptamers for the capture of circulating tumor cells, Chemical Communications, 10.1039/c5cc06211j, 51, 98, 17428-17430, 2015.01, In order to enhance the interactions between macrophages and cancer cells, thiol-terminated nucleic acid aptamers were immobilized on methacryloyl-functionalised carbohydrates of macrophages. The adhesion of cancer cells on the surface modified macrophages was significantly accelerated..
58. Daiki Funamoto, Daisuke Asai, Chan Woo Kim, Yuta Nakamura, Eun Kyung Lee, Takanobu Nobori, Takuro Niidome, Takeshi Mori, Yoshiki Katayama, Tandemly repeated peptide for cancer-specific gene carrier prepared by native chemical ligation, Chemistry Letters, 10.1246/cl.141121, 44, 4, 474-476, 2015.01, We reported here a preparation of a cancer-specific gene carrier by native chemical ligation of a substrate peptide of protein kinase Cα (PKCα), which highly expresses in many types of cancer. This carrier is a tetramer of the substrate peptide connected with adequate spacer to maintain reactivity toward PKCα. The carrier successfully regulated the reporter gene expression responding to the phosphorylation of its serine residues..
59. Eun Kyung Lee, Chan Woo Kim, Hiroyuki Kawanami, Akihiro Kishimura, Takuro Niidome, Takeshi Mori, Yoshiki Katayama, Utilization of a PNA-peptide conjugate to induce a cancer protease-responsive RNAi effect, RSC Advances, 10.1039/c5ra17737e, 5, 104, 85816-85821, 2015.01, Small interfering RNA (siRNA) is regarded as a promising tool for cancer therapy because of the wide applicability to various cancer-related genes. However, non-specific delivery of siRNA is one of the major causes of adverse effects. To access the issue, here we designed a new siRNA system which turns on RNAi responding to a cancer cell-specific protease, cathepsin B. The system uses a peptide nucleic acid (PNA)-peptide conjugate to provide this protease-responsive activation. The PNA-peptides were found to form hybrids with double-stranded RNAs with complementary protruding regions, which then affected the susceptibility of dsRNA to Dicer. The dsRNA/PNA-peptide hybrids were activated in cancer cells with a high cathepsin B activity to show RNAi..
60. Masayoshi Matsuda, Wataru Hatanaka, Masafumi Takeo, Chan Woo Kim, Takuro Niidome, Tatsuhiro Yamamoto, Akihiro Kishimura, Takeshi Mori, Yoshiki Katayama, Short peptide motifs for long-lasting anchoring to the cell surface, Bioconjugate Chemistry, 10.1021/bc500465j, 25, 12, 2134-2143, 2014.12, A rational design strategy has been developed for the construction of stable peptide-based anchors for the efficient modification of cell surfaces. Six types of peptide composed of five residues with divalent hydrophobic groups have been designed using this new strategy. Among them, a peptide with a sequence of NBD-Lys-Lys(X)-Lys-Lys-Lys(X)-NH2 (NBD: fluorophore, Lys(X): N-ε-palmitoyl-L-lysine) was found to show the highest modification efficacy and longevity in culture medium. The good performance of this peptide was attributed to (1) its high aqueous solubility, which allowed it to partition from the medium to the cell surface, and (2) the high binding affinity of the saturated palmitoyl groups to the cell membrane. We found that the distribution of the peptide was affected by recycling endosome, which enabled the representation of the peptide following its endocytotic disappearance from the cell membrane. Biotin was also presented on the cell surface using this peptide-based anchor to examine its recognition by streptavidin. The efficacy of the recognition process increased as the length of the oligoethylene glycol spacer increased, indicating that it was necessary for the biotin tag to move away from the membrane glycoproteins on the cell surface to facilitate its efficient recognition by streptavidin. (Figure Presented)..
61. Riki Toita, Jeong Hun Kang, Chan Woo Kim, Shujiro Shiosaki, Takeshi Mori, Takuro Niidome, Yoshiki Katayama, Effect of peptide content on the regulation of transgene expression by protein kinase Cα-responsive linear polyethylenimine-peptide conjugates, Colloids and Surfaces B: Biointerfaces, 10.1016/j.colsurfb.2014.09.004, 123, 123-129, 2014.11, We examined a series of linear polyethylenimine (LPEI)-based nanocarriers that activate transgene expression in response to cancer-specific protein kinase Cα (PKCα). Eight types of LPEI-peptide conjugate differing in peptide content and number were synthesized using click chemistry. The conjugates could form polyplexes with pDNA through electrostatic interaction, but the degree of pDNA condensation, sizes, and surface charges of the resulting polyplexes depended on the pendant-peptide content and number. None of the polyplexes showed significant cytotoxicity toward human hepatoma cells (HepG2). Furthermore, pendant peptide content and number markedly affected transgene activation in response to PKCα. To achieve an all-or-none response to PKCα, we determined the optimum peptide content and number in LPEI-peptide conjugates as ≈6. mol% and ≈40. peptides/conjugate..
62. Takuro Niidome, Hisayo Yamauchi, Kayo Takahashi, Kenshiro Naoyama, Kazuto Watanabe, Takeshi Mori, Yoshiki Katayama, Hydrophobic cavity formed by oligopeptide for doxorubicin delivery based on dendritic poly(L-lysine), Journal of Biomaterials Science, Polymer Edition, 10.1080/09205063.2014.938979, 25, 13, 1362-1373, 2014.09, To deliver anti-cancer drugs to tumors, a hydrophobic cavity was prepared in the dendritic molecule, dendritic poly(L-lysine) of sixth generation (KG6), which was used as a drug carrier. The dendritic molecule was modified with polyethylene glycol (PEG)-linked hydrophobic penta-phenylalanine or penta-Alanine. The hydrophobic cavity was formed between the KG6 and PEG chains. The penta-phenylalanine peptide was better in encapsulating doxorubicin (DOX) in the cavity compared with penta-Alanine. The loaded DOX was slowly released from the cavity, and it depended on pH. After intravenous injection, the DOX-loaded dendrimers accumulated in the tumor by the enhanced permeability and retention effect, and showed significant suppression of tumor growth without loss of body weight. These results indicate that hydrophobic oligopeptides can be used for forming a hydrophobic cavity in a dendritic molecule for delivery of anti-cancer drugs to tumor sites..
63. Takuro Niidome, Risa Gokuden, Kazuto Watanabe, Takeshi Mori, Tatsuya Naganuma, Hideo Utsumi, Kazuhiro Ichikawa, Yoshiki Katayama, Nitroxyl radicals-modified dendritic poly(l -lysine) as a contrast agent for Overhauser-enhanced MRI, Journal of Biomaterials Science, Polymer Edition, 10.1080/09205063.2014.943538, 25, 13, 1425-1439, 2014.09, Overhauser-enhanced magnetic resonance imaging (OMRI), which is a double resonance technique, creates images of free radical distribution in animals by enhancing the water proton signal intensity by the overhauser effect. In this study, we constructed a contrast agent by combining PROXYL groups that have nitroxyl radicals with PEG-modified dendritic poly(l-lysine) that accumulates in the tumor by enhanced permeability and retention (EPR) effect. Addition of the PROXYL groups at the PEG chains termini on KG6 was advantageous in OMRI, because the ESR signal of the nitroxyl radical was maintained without decay caused by mobility restriction, even if the PROXYL groups were attached at 25 mol% on one molecule. After intramuscular injection of the molecule modified at 25 mol%, that is, PR25-PEG-KG6, a significant OMRI signal was observed at the injected site. However, no signal was detected in the tumor after intravenous injection of PR25-PEG-KG6 to a tumor-bearing mouse, although PR 25-PEG-KG6 itself accumulated in the tumor. The reason was that the nitroxyl radicals were immediately reduced in the blood after the injection, suggesting that use of stable nitroxyl radicals will enable detection of tumors by OMRI after intravenous injection..
64. K Tobinaga, C Li, M Takeo, T Niidome, Akihiro Kishimura, Takeshi Mori, Yoshiki Katayama, Rapid and serum-insensitive endocytotic delivery of proteins using biotinylated polymers attached via multivalent hydrophobic anchors, J. Controlled Release, 177, 27, 2014.08.
65. T. Niidome, N. Chijiiwa, T. Yamasaki, K. Yamada, Takeshi Mori, T. Naganuma, H. Utsumi, H. Utsumi, Yoshiki Katayama, Change in Overhauser Effect-enhanced MRI Signal in Response to uPA Highly Expressing in Tumor, Chem Lett, 43, 999, 2014.08.
66. M. Matsuda, W. Hatanaka, M. Takeo, C. W. Kim, T. Niidome, T. Yamamoto, Akihiro Kishimura, Takeshi Mori, Yoshiki Katayama, Short Peptide Motifs for Long-Lasting Anchoring to the Cell Surface, Bioconjugate Chem., 25, 2134, 2014.08.
67. GX Zhao, H Tanaka, CW Kim, K Li, D Funamoto, T Nobori, Y Nakamura, T Niidome, Akihiro Kishimura, Takeshi Mori, Yoshiki Katayama, Histidinylated poly-L-lysine-based vectors for cancer-specific gene expression via enhancing the endosomal escape, J. Biomater. Sci. Polym. Ed., 25, 519, 2014.07.
68. H. Sato, Y. Nakamura, E. Nakhaei, D.Funamoto, C. W. Kim, T. Yamamoto, Akihiro Kishimura, Takeshi Mori, Yoshiki Katayama, A liposome reversibly coated with serum albumin, Chem. Lett., 43, 1481, 2014.06.
69. H. Ikeda, Y. Yayama, A. Hata, J. Kamimotoa, T. Yamamoto, Takeshi Mori, Yoshiki Katayama, PNA-tagged peptide microarrays for ratiometric activity detection of cellular protein kinases, Anal. Sci., 30, 631, 2014.05.
70. T. Nobori, S. Shiosaki, Takeshi Mori, R. Toita, C. W. Kim, Y. Nakamura, A. Kishimura, T. Niidome, Yoshiki Katayama, A fluorescent polyion complex nanoparticle that incorporates an internal standard for quantitative analysis of protein kinase activity, Bioconjugate Chem., 25, 869, 2014.05.
71. T. Yamamoto, Takeshi Mori, Yoshiki Katayama, Microarray Technologies for Intracellular Kinome Analysis, Current Med. Chem., 21, 2542, 2014.05.
72. Takeshi Mori, H. Tang, H. Kobayashi, Y. Niidome, Yoshiki Katayama, T. Niidome, CW/pulsed NIR irradiation of gold nanorods: Effect on transdermal protein delivery mediated by photothermal ablation, J. Controlled Release, 171, 178-183, 2013.10.
73. T. Hirano, A. Ono, H. Yamamoto, Y. Maeda, Takeshi Mori, M. Oshimura, K. Ute, Effect of composition and stereoregularity on phase-transition behavior of aqueous N-ethylacrylamide/N-n-propylacrylamide copolymer solutions, Polymer, 54, 56015608, 2013.10.
74. C. W. Kim, R. Toita, J.-H. Kang, K. Li, E. K. Lee, G. X. Zhao, D. Funamoto, T. Nobori, Takeshi Mori, T. Niidome, Y. Nakamura, Yoshiki Katayama, Stabilization of Cancer-specific Gene Carrier via Hydrophobic Interaction for a Clear-cut Response to Cancer Signaling, J. Controlled Release, 170, 469-476, 2013.07.
75. J.-H. Kang, Takeshi Mori, H. Kitazaki, T. Niidome, Y. Nakanishi, K. Takayama, Yoshiki Katayama, Serum protein kinase Cα as a diagnostic biomarker of cancers, Cancer Biomarker, 13, 99-103, 2013.07.
76. H. Ikeda, J. Kamimoto, T. Yamamoto, A. Hata, Y. Otsubo, T. Niidome, M. Fukushima, Takeshi Mori, Yoshiki Katayama, A peptide microarray fabricated on a non-fouling phosphatidylcholine-polymer-coated surface for a high-fidelity analysis of a cellular kinome, Current Med. Chem., 20, 4419-25, 2013.06.
77. Y. Nakamura, C. W. Kim, A. Tsuchiya, S. Kushio, K. Li, T. Nobori, E. K. Lee, G. Xi Zhao, D. Funamoto, T. Niidome, Takeshi Mori, Yoshiki Katayama, Branched polyethylenimine-based PKCα-responsive gene carriers, J. Biomater. Sci.-Polym. Ed., 24, 1858-1868, 2013.06.
78. Takeshi Mori, S. Shiosaki, T. Nobori, R. Toita, Y. Nakamura, C. W. Kim, T. Yamamoto, T. Niidome, Yoshiki Katayama, A protein kinase assay based on FRET between quantum dots and fluorescently-labeled peptides, Chem. Commun., 49, 5592-5594, 2013.04.
79. J.-H. Kang, Takeshi Mori, H. Kitazaki, T. Niidome, K. Takayama, Y. Nakanishi, Yoshiki Katayama, Kinase Activity of Protein Kinase Calpha in Serum as a Diagnostic Biomarker of Human Lung Cancer, Anticancer, 33, 485-488, 2013.03.
80. J.-H. Kang, Takeshi Mori, H. Kitazaki, T. Niidome, K. Takayama, Y. Nakanishi, Yoshiki Katayama, Kinase Activity of Protein Kinase Calpha in Serum as a Diagnostic Biomarker of Human Lung Cancer, Anticancer, 33, 485-488, 2013.03.
81. K. Wakigawa, A. Gohda, S. Fukushima, Takeshi Mori, Yoshiki Katayama, Rapid and Selective determination of free chlorine in aqueous solution using electrophilic addition to styrene by gas chromatography/mass spectrometry, Talanta, 203, 81-85, 2013.02.
82. Y. Sakamura, M. Yoshiura, H. Tang, Takeshi Mori, Yoshiki Katayama, T. Niidome, Thermal enhancement of gene transfection in tumor cells mediated by the photothermal effect of gold nanorods, Chem. Lett., 42, 767-768, 2013.02.
83. M. R. Berber, I. H. Hafez, K. Minagawa, Takeshi Mori, M. Katoh, M. Tanaka, Uniform nanoparticles of hydrotalcite-like materials and their textural properties at optimized conditions of urea hydrothermal treatment, J Mol Struct, 1033, 104-112, 2013.01.
84. Takeshi Mori, A colorimetric assay of protein kinase activity based on peptide-induced coagulation of gold nanorods, J. Collod. Interf. Sci. B: Biointerfaces, 99, 7, 2012.10.
85. H. Fukushima, Takuro Niidome, S. Yamashita, Takeshi Mori, Yoshiki Katayama, Yasuro Niidome, Controlled-Release System Mediated by a Retro Diels-Alder Reaction Induced by the Photothermal Effect of Gold Nanorods, Langmuir, 27, 14621, 2012.10.
86. A. Hashidzume, A. Matsumoto, T. Mori, T. Shikata, T. Sato, Phase Behavior of Aqueous Solutions of Copolymers of N,N’-Diisopropylfumaramide and N-Isopropylacrylamide: Effect of the Density of Side Chains, Langmuir, 28, 5522, 2012.07.
87. Takeshi Mori, Yoshiki Katayama, Riki Toita, Gene carrier showing all-or-none response to cancer cell signaling, J. Am. Chem. Soc., 134, 15410-15417, 2012.07, In this work we designed a novel nano carrier, a linear polyethylenimine (LPEI)-peptide conjugate, for cancerspecific expression of transgenes. The conjugate was easily synthesized by using a click chemistry scheme orthogonal to the reactive side groups of the peptide, which is the substrate of protein kinase Cα (PKCα). Polyplexes of the conjugates with plasmid DNA (pDNA) were intact and stably dispersed even in the presence of cell lysate. Despite this stability, the polyplexes readily dissociated upon phosphorylation of the grafted peptides by PKCα. Because of its endosomal escape ability and adequate susceptibility to PKCα, the polyplexes
showed an all-or-none type response to PKCα activity in transgene expression in vitro. The polyplexes achieved cancer tissuespecific
transgene expression even for a tumor with a relatively low PKCα activity. Thus the LPEI−peptide conjugate has high potential as a nanocarrier for cancer-targeted gene therapy..
88. Takeshi Mori, Fluorometric detection of protein kinase Calpha activity based on phosphorylation-induced dissociation of a polyion complex, Anal. Biochem., 424, 130, 2012.05.
89. H. Tanaka, T. Mori, T. Niidome, Y. Katayama, Creating a unique environment for selecting reactive enzymes with DNA: ‘Sticky’ binding of oligocation-grafted polymers to DNA, Bioorg. Med. Chem., 20, 1346, 2012.04.
90. A. Tsuchiya, Y. Naritomi, S. Kushio, J.-H. Kang, M. Murata, M. Hashizume, T. Mori, T. Niidome, Y. Katayama, Improvement in the colloidal stability of protein kinase-responsive polyplexes by PEG modification, J. Biomed. Mater. Res. Part A, 100, 1136, 2012.04.
91. Takeshi Mori, Improvement in the colloidal stability of protein kinase-responsive polyplexes by PEG modification, J. Biomed. Mater. Res. Part A, 100, 1136-1141, 2012.04.
92. A Hashidzume, A. Matsumoto, T. Shikata, Takeshi Mori, T. Sato, Phase Behavior of Aqueous Solutions of Copolymers of N,N’-Diisopropylfumaramide and N-Isopropylacrylamide: Effect of the Density of Side Chains, Langmuir, 2012.04.
93. Takeshi Mori, Conversion of rod-shaped gold nanoparticles to spherical forms and their effect on biodistribution in tumor-bearing mice, Nanoscale Res. Lett., 7, 565, 2012.04.
94. Takeshi Mori, Sequential release of single-stranded DNAs from gold nanorods triggered by near-infrared light irradiation, Chem. Lett., 41, 711-712, 2012.04.
95. R. Kurihara, D. Pissuwan, T. Mori, Y. Katayama, T. Niidome, Biodistribution and tumor localization of PEG-modified dendritic poly(L-lysine) oligonucleotide complexes, J. Biomater. Sci.-Polym. Ed., 23, 2369, 2012.02.
96. R. Kurihara, D. Pissuwan, Takeshi Mori, Yoshiki Katayama, Takuro Niidome, Biodistribution and tumor localization of PEG-modified dendritic poly(L-lysine) oligonucleotide complexes, J. Biomater. Sci.-Polym. Ed., 23, 2369-2380, 2012.02.
97. Y. Asami, J. Oishi, H. Kitazaki, J. Kamimoto, J.-H. Kang, T. Niidome, T. Mori, Y. Katayama, A simple set-and-mix assay for screening of protein kinase inhibitors in cell lysates, Anal. Biochem., 418, 44-49 (2011)., Anal Biochem, 418, 44-49, 2011.06.
98. S. Shiosaki, M. Kuramoto, R. Toita, T. Mori, T. Niidome, Y. Katayama, A hydrophilic polymer grafted with a histone tail peptide represents an artificial gene regulator activated by a histone acetyltransferase, Bioorg. Med. Chem., 19, 4101-41405 (2011)., Bioorg Med Chem, 19, 4101-41405, 2011.05.
99. J.-H. Kang, D. Asai, J.-H. Kim, T. Mori, R. Toita, T. Tomiyama, Y. Asami, J. Oishi, Y. T. Sato, T. Niidome, B. Jun, H. Nakashima, Y. Katayama, Design of polymeric carriers for cancer-specific gene targeting: Utilization of abnormal protein kinase Cα activation in cancer cells, J. Am. Chem. Soc, 130, 14906-14907, 2009.10.
100. K. Watanabe, M. Harada-Shiba, A. Suzuki, R. Gokuden, R. Kurihara, Y. Sugao, T. Mori, Y. Katayama, T. Niidome, In vivo siRNA delivery with dendritic poly(L-lysine) for the treatment of hypercholesterolemia, Molecular BioSystems, 5, 1306-1310, 2009.06.
101. K. Watanabe, M. Harada-Shiba, A. Suzuki, R. Gokuden, R. Kurihara, Y. Sugao, T. Mori, Y. Katayama, T. Niidome, In vivo siRNA delivery with dendritic poly(L-lysine) for the treatment of hypercholesterolemia, Molecular BioSystems, 5, 1306-1310, 2009.06.
102. K. Watanabe, M. Harada-Shiba, A. Suzuki, R. Gokuden, R. Kurihara, Y. Sugao, T. Mori, Y. Katayama, T. Niidome, In vivo siRNA delivery with dendritic poly(L-lysine) for the treatment of hypercholesterolemia, Molecular BioSystems, 5, 1306-1310, 2009.06.
103. T. Mori*, T. Hirano, A. Maruyama, Y. Katayama, T. Niidome, Y. Bnado, K. Ute, S. Takaku, Y. Maeda, Syndiotactic poly(N-n-propylacrylamide) shows highly cooperative phase transition, Langmuir, 25, 48-50, 2009.01.
104. Jeong-Hun Kang, Daisuke Asai, Satoshi Yamada, Toita Riki, Jun Oishi, Takeshi Mori, Takuro Niidome, Yoshiki Katayama, Novel peptide is a protein kinase C (PKC)α-specific substrate, Proteomics, 2008.08.
105. Takuro Niidome, Yasuyuki Akiyama, Kohei Shimoda, Takahito Kawano, Takeshi Mori, Yoshiki Katayama, and Yasuro Niidome, In vivo monitoring of intravenously injected gold nanorods using near-infrared light, Small, 2008.07.
106. Jeong-Hun Kang, Takeshi Mori, Takuro Niidome, Yoshiki Katayama, A syngeneic hepatocellular carcinoma model rapidly and simply prepared using a hydrodynamics-based procedure, Vet. J, 2008.07.
107. Jeong-Hun Kang, Masanori Kuramoto, Akira Tsuchiya, Riki Toita, Daisuke Asai, Yuko T. Sato, Takeshi Mori, Takuro Niidome, Yoshiki Katayama, Correlation between phosphorylation ratios by MALDI-TOF MS analysis and enzyme kinetics, Eur. J. Mass Spectrom., , 2008.07.
108. Takuro Niidome, Yasuyuki Akiyama, Masato Yamagata, Takahito Kawano, Takeshi Mori, Yasuro Niidome, Yoshiki Katayama, PEG-modified gold nanorods as a photothermal nanodevice for hyperthermia, J. Biomater. Sci.-Polym. Ed, 2008.07.
109. Jun Oishi, Yoji Asami, Takeshi Mori, Jeong-Hun Kang, Takuro Niidome, Yoshiki Katayama, Colorimetric enzymatic activity assay based on "non-crosslinking aggregation" of gold nanoparticles induced by adsorption of substrate peptides, Biomacromolecules, 2008.07.
110. Yusuke Inoue, Takeshi Mori, Go Yamanouchi, Xiaoming Han, Tatsuhiko Sonoda, Takuro Niidome, Yoshiki Katayama, Surface plasmon resonance imaging measurements of caspase reactions on peptide microarrays, Anal. Biochem., 375, 147-149 , 2008.04.
111. Kenjiro Ikuta, Takeshi Mori, Tatsuhiro Yamamoto, Takuro Niidome, Hiroaki Shimokawa, Yoshiki Katayama, Development of polymeric drug delivery system for recognizing vascular endothelial dysfunction, Bioorg. Med. Chem., 16, 2811-2818 , 2008.04.
112. Kenjiro Ikuta, Takeshi Mori, Tatsuhiro Yamamoto, Takuro Niidome, Hiroaki Shimokawa, Yoshiki Katayama, Development of polymeric drug delivery system for recognizing vascular endothelial dysfunction, Bioorg. Med. Chem., 16, 2811-2818 , 2008.04.
113. Jeong-Hun Kang, Daisuke Asai, Jun Oishi, Kenji Kawamura, Riki Toita, Yuhua Jiang, Takeshi Mori, Takuro Niidome, Yoshiki Katayama, Role of plasma as activator and cofactor in phosphorylation by protein kinase C, Cell Biochem. Funct, 26, 70-75 , 2007.12.
114. J. Oishi, Y. Asami, T. Mori*, J.-H. Kang, M. Tanabe, T. Niidome, Y. Katayama, Measurement of Homogeneous Kinase Activity for Cell Lysates Based on Aggregation of Gold Nanoparticles, ChemBioChem, 8, 875-879, 2007.06.
115. Measurement of homogeneous kinase activityfor cell lysates based on the aggregation of gold nanoparticles, Measurement of homogeneous kinase activityfor cell lysates based on the aggregation of gold nanoparticles, ChemBioChem, 8, 875-879, , 2007.05.
116. Xiaoming Han, Syuhei Shigaki, Takayuki Yamaji, Go Yamanouchi, Takeshi Mori, Takuro Niidome, Yoshiki Katayama, A quantitative peptide array for evaluation of protein kinase activity, Anal. Biochem, 372, 106-115, 2007.04.
117. T. Mori, M. Nakashima, Y. Fukuda, K. Minagawa, M. Tanaka, Y. Maeda, Soluble-Insoluble-Soluble Transitions of Aqueous Poly(N-vinylacetamide-co-acrylic acid) Solutions, Langmuir, Vol. 22, No. 9, pp4336-4342, 2006.03.
118. T. Mori, K. Yuyama, K. Narita, K. Minagawa, M. Haraguchi, M. Tanaka, Preparation of Nano- and Micro-Particles through Self-Assembly of Azobenzen-Pendent Ionomers, Journal of Applied Polymer Science, 2006.01.
119. J.-H. Kang, Y. Jiang, R. Toita, J. Oishi, K. Kawamura, A. Han, T. Mori, T. Niidome, M. Ishida, K. Tatematsu, K. Tanizawa, Y. Katayama, Phosphorylation of Rho-associated kinase (Rho-kinase/ROCK/ROK) substrates by protein kinases A and CPhosphorylation of Rho-associated kinase (Rho-kinase/ROCK/ROK) substrates by protein kinases A and C, Biochimie, in press, 2006.01.
120. T. Mori, M. Hamada, T. Kobayashi, H. Okamura, K. Minagawa, S. Masuda, M. Tanaka, Effect of Alkyl Substituents Structures and Added Ions on the Phase Transition of Polymers and Gels Prepared from Methyl 2-Alkylamidoacrylates, Journal of Polymer Science, Part A: Polymer Chemistry Edition, 2005.10.
121. T. Mori, T. Watanabe, K. Minagawa, M. Tanaka, Self-assembly of Oligo(p-phenylenevinylene)-block-Poly(ethylene oxide) in Polar Media and Solubilization of an Oligo(p-phenylenevinylene) Homooligomer inside the Assembly, Journal of Polymer Science, Part A: Polymer Chemistry Edition, Vol. 43, No.8, pp 1569-1578, 2005.04.
122. T. Mori, Y. Shiota, K. Minagawa, M. Tanaka, Alternative Approach to the Design of Thermosensitive Polymer: The Addition of Hydrophobic Groups to Ends of Hydrophilic Polyether, Journal of Polymer Science, Part A: Polymer Chemistry Edition, Vol. 43, No. 5, pp 1007-1013, 2005.03.
123. T. Mori, K. Shimoyama, Y. Fukawa, K. Minagawa, M. Tanaka, Parallel beta-sheet as a Novel Template for Polymerization of Diacetylene, Chemistry Letters, Vol. 34, No. 1, pp 116-117, 2005.01.
124. T. Mori, Y. Fukuda, H. Okamura, K. Minagawa, S. Masuda, M. Tanaka, Thermosensitive Copolymers Having Soluble and Insoluble Monomer Units, Poly(N-vinylacetamide-co-methyl acrylate)s: Effect of Additives on Their Lower Critical Solution Temperatures, Journal of Polymer Science, Part A: Polymer Chemistry Edition, Vol. 42, No. 11, pp 2651-2658, 2004.06.
125. T. Mori, M. Maeda, Temperature-Responsive Formation of Colloidal Nanoparticles from Poly(N-isopropylacrylamide) Grafted with Single-Stranded DNA, Langmuir, 10.1021/la0356194, 20, 2, 313-319, Vol. 20, No. 2, pp 313-319, 2004.01.
126. T. Mori, M. Maeda, Stability Change of DNA-Carrying Colloidal Particle Induced by Hybridization with Target DNA, Polymer Journal, 10.1295/polymj.34.624, 34, 8, 624-628, Vol. 34, No. 8, pp 624-628, 2002.08.
127. H. Okamura, Y. Morihara, S. Masuda, K. Minagawa, T. Mori, M. Tanaka, Effects of Salts and Copolymer Composition on Lower Critical Solution Temperature of Poly(methyl 2-acetamidoacrylate-co-methyl methacrylate) Solution, Journal of Polymer Science, Part A: Polymer Chemistry Edition, Vol. 40, No. 12, pp 1945-1951, 2002.06.
128. H. Okamura, T. Mori, K. Minagawa, S. Masuda, M. Tanaka, A Novel Thermosensitive Polymer, Poly(methyl 2-propionamidoacrylate), with Geminal Substituents, Polymer, Vol. 43, No. 13, pp 3825-3828, 2002.06.
129. H. Okamura, S. Masuda, K. Minagawa, T. Mori, M. Tanaka, Thermosensitive Properties of a Novel Poly(methyl 2-acetamidoacrylate-co-methyl acrylate), European Polymer Journal, Vol. 38, No. 4, pp 639-644, 2002.04.
130. H. Okamura, K. Suzuki, T. Mori, K. Minagawa, S. Masuda, M. Tanaka, Chain Behavior in Model Homogeneous ER Fluids Depending on Temperature, International Journal of Modern Physics B, Vol. 16, No. 17-18, pp 2385-2391, 2002.01.
131. K. Minagawa, K. Saitoh, H. Okamura, T. Mori, S. Masuda, M. Tanaka, Electric-Field Response of the Structure and Rheological Property of Silicone/Polyether Blends, International Journal of Modern Physics B, Vol. 16, Nos. 17-18, pp 2474-2480, 2002.01.
132. K. Minagawa, T. Kanno, H. Okamura, T. Mori, S. Masuda, H. Takagi, K. Koyama, M. Tanaka, Novel Electrorheological Materials with Ternary Blends Containing Polyethers and Urethanes, International Journal of Modern Physics B, Vol. 16, Nos. 17-18, pp 2481-2486, 2002.01.
133. H. Okamura, T. Maruyama, S. Masuda, K. Minagawa, T. Mori, M. Tanaka, A Novel Thermosensitive Poly(methyl 2-acetamidoacrylate), Journal of Polymer Research, Vol. 9, No. 1, pp 17-21, 2002.01.
134. T. Mori, M. Maeda, Formation of DNA-Carrying Colloidal Particle from Poly(N-isopropylacrylamide)-graft-DNA Copolymer and Its Assembly through Hybridization, Polymer Journal, 33, 10, 830-833, Vol. 33, No. 10, pp 830-833, 2001.10.
135. T. Mori, D. Umeno, M. Maeda, Sequence-specific Affinity Precipitation of Oligonucleotide Using Poly(N-isopropylacrylamide) -Oligonucletide Conjugate, Biotechnolgy and Bioengineering, 10.1002/1097-0290(20010205)72:3<261::AID-BIT2>3.0.CO;2-7, 72, 3, 261-268, Vol. 72, No. 3, pp 261-268, 2001.02.
136. J. Oishi, M. Ijuin, T. Sonoda, J.-H. Kang, K. Kawamura, T. Mori, T. Niidome, Y. Katayama, A protein kinase signal-responsive gene carrier modified RGD peptide, Bioorg. Med. Chem. Lett., in press.
137. Y. Otsubo, H. Ikeda, J. Kamimoto, T. Niidome, Takeshi Mori, Yoshiki Katayama, A Rapid and Quantitative Detection of Cellular Protein Kinase Activity Based on MALDI-TOF-MS, Chem. Lett., 43, 658.
138. C.W. Kim, D. Asai, J.-H. Kang, Akihiro Kishimura, Takeshi Mori, Yoshiki Katayama, Reversal of efflux of an anticancer drug in human drug-resistant breast cancer cells by inhibition of protein kinase C alpha activity, Tumor Biol.