九州大学 研究者情報
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基本情報 研究活動 教育活動 社会活動
北島 桂子(きたじま けいこ) データ更新日:2020.06.01

助教 /  医学研究院 基礎医学部門 生体防御学


主な研究テーマ
マウスの体軸形成に関する発生生物学的、分子生物学的解析
キーワード:マウス、初期胚発生、左右軸
2006.04.
研究業績
主要原著論文
1. 北島 桂子, 角 智行, 沖 真弥, 大川 恭行, 目野 主税, Wnt signaling regulates left-right axis formation in the node of mouse embryos., Developmental Biology, 10.1016/j.ydbio.2013.05.011, 380, 2, 222-232, 2013.08, The node triggers formation of the left-right axis in mouse embryos by establishing local asymmetry of Nodal and Cerl2 expression. We found that Wnt3 is expressed in perinodal crown cells preferentially on the left side. The enhancer responsible for Wnt3 expression was identified and found to be regulated by Foxa2 and Rbpj under the control of Notch signaling. Rbpj binding sites suppress enhancer activity in pit cells of the node, thereby ensuring crown cell-specific expression. In addition, we found that the expression of Gdf1 and Cerl2 is also regulated by Notch signaling, suggesting that such signaling may induce the expression of genes related to left-right asymmetry as a set. Furthermore, Cerl2 expression became symmetric in response to inhibition of Wnt-β-catenin signaling. Our results suggest that Wnt signaling regulates the asymmetry of Cerl2 expression, which likely generates a left-right difference in Nodal activity at the node for further amplification in lateral plate mesoderm..
2. Oki S, Kitajima K, Meno C., Dissecting the role of Fgf signaling during gastrulation and left-right axis formation in mouse embryos using chemical inhibitors., Developmental Dynamics, 10.1002/dvdy.22282, 239, 6, 1768-1778, 2010.06.
3. Oki S., Kitajima K., Marques S., Belo JA., Yokoyama T., Hamada H., Meno C., Reversal of left-right asymmetry induced by aberrant Nodal signaling in the node of mouse embryos., Development, 136, 23, 3917-3925, 2009.12.
主要学会発表等
1. 北島 桂子, 角 智行, 沖 真弥, 目野 主税, Wnt signaling regulates the left-right axis formation in the node of mouse embryos, 46th Annual Meeting of JSDB, 2013.05.
2. 北島 桂子, 角 智行, 沖 真弥, 目野 主税, Wnt signaling regulates the left-right axis formation in the node, MOUSE MOLECULAR GENETICS, 2013.09, The node triggers formation of the left-right axis in mouse embryos by establishing local asymmetry of Nodal and Cerl2 expression. We found that Wnt3 is expressed in perinodal crown cells preferentially on the left side. The enhancer responsible for Wnt3 expression was identified and found to be regulated by Foxa2 and Rbpj under the control of Notch signaling. Rbpj binding sites suppress enhancer activity in pit cells of the node, thereby ensuring crown cell–specific expression. In addition, we found that the expression of Gdf1 and Cerl2 is also regulated by Notch signaling, suggesting that such signaling may induce the expression of genes related to left-right asymmetry as a set. Furthermore, Cerl2 expression became symmetric in response to inhibition of Wnt–β-catenin signaling. Our results suggest that Wnt signaling regulates the asymmetry of Cerl2 expression, which likely generates a left-right difference in Nodal activity at the node for further amplification in lateral plate mesoderm..
研究資金
科学研究費補助金の採択状況(文部科学省、日本学術振興会)
2018年度~2020年度, 基盤研究(C), 代表, 高血糖曝露により生じる胎児の左右軸形態異常に関する分子機構の解明.
2014年度~2017年度, 基盤研究(C), 代表, 糖尿病で生じる胎児の左右軸形態異常の分子機構解析.

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