| Hiroshi YOSHIDA | Last modified date：2023.05.02 |
Associate Professor /
Division of Analysis /
Faculty of Mathematics
Papers
| 1. | Hiroshi Yoshida, A model for analyzing phenomena in multicellular organisms with multivariable polynomials: Polynomial Life, Int. J. Biomath., 11, 1, 1850007, 2018.01. |
| 2. | Hiroshi Yoshida, Tetsuya Bando, Taro Mito, Hideyo Ohuchi, Sumihare Noji, An extended steepness model for leg-size determination based on Dachsous/Fat trans-dimer system, Scientific Reports, 10.1038/srep04335, 4, 4335, 2014.03, [URL], What determines organ size has been a long-standing biological question. Lawrence et al. (2008) proposed the steepness hypothesis suggesting that the protocadherin Dachsous/Fat (Ds/Ft) system may provide some measure of dimension to the cells in relation to the gradient. In this paper we extended the model as a means of interpreting experimental results in cricket leg regeneration. We assumed that (1) Ds/Ft trans-heterodimers or trans-homodimers are redistributed during cell division, and (2) growth would cease when a differential of the dimer across each cell decreases to a certain threshold. We applied our model to simulate the results obtained by leg regeneration experiments in a cricket model. The results were qualitatively consistent with the experimental data obtained for cricket legs by RNA interference methodology. Using our extended steepness model, we provided a molecular-based explanation for leg size determination even in intercalary regeneration and for organ size determination.. |
| 3. | Hiroshi Yoshida, A pattern to regenerate through turnover, Biosystems, 10.1016/j.biosystems.2012.08.001, 110, 43-50, 2012.09, [URL]. |
| 4. | Hiroshi Yoshida, A condition for regeneration of a cell chain inspired by the Dachsous-Fat system, Journal of Math-for-Industry, 3, 93-98, 2011.10. |
| 5. | Hiroshi Yoshida, Yoshihiro Miwa, Masanobu KANEKO, Elliptic curves and Fibonacci numbers arising from Lindenmayer system with Symbolic Computation, Applicable Algebra in Engineering, Communication and Computing, 10.1007/s00200-011-0143-7, 22, 2, 147-164, 2011.04, [URL]. |
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