Kyushu University Academic Staff Educational and Research Activities Database
List of Papers
Ken-ichirou Morohashi Last modified date:2021.05.21

Professor / Biology of sex differences / Department of Molecular Biology / Faculty of Medical Sciences


Papers
1. Ken-ichirou Morohashi, Miki Inoue, Takashi Baba, Coordination of multiple cellular processes by NR5A1/Nr5a1, Endocrinology and Metabolism, org/10.3803/EnM.2020.402, 35, 756-764, 2020.11.
2. Hiroki Yamazaki, Mayu Nishimura, Masaaki Uehara, Akiko Kuribara-Souta, Motohisa Yamamoto, Noritada Yoshikawa, Ken-ichirou Morohashi, Hirotoshi Tanaka, Eicosapentaenoic acid changes muscle transcriptome and intervenes in aging-related fiber type transition in male mice, Am J Physiol Endocrinol Metab, 10.1152/ajpendo.00184.2020, 320, 2021.02.
3. S Shogo Yanai, Takashi Baba, Kai Inui, Kanako Miyabayashi, Soyun Han, Miki Inoue, Fumiya Takahashi, Yoshiakira Kanai, Yasuyuki Ohkawa, Man Ho Choi, Ken-Ichirou Morohashi, Gene expression and functional abnormalities in XX/Sry Leydig cells., Scientific Report, 10.1038/s41598-020-80741-z, 11, 2021.01.
4. Soyun Han, Takashi Baba, Shogo Yanai, Dong Jun Byun, Ken-ichirou Morohashi, Jae-Hong Kim, and Man Ho Choi, GC-MS-based metabolic signatures reveal comparative steroidogenic pathways between fetal and adult mouse testes., Andrology , org/10.1111/andr.12893, 9, 400-406, 2021.04.
5. Chikako Yokoyama, Yuta Chigi, Takashi Baba, Atsushi Ohshitanai, Yumi Harada, # Fumiya Takahashi, Ken-ichirou Morohashi, Three population of adult Leydig cells in mouse testes revealed by a novel mouse HSD3B1-specific rat monoclonal antibody, BBRC, https://doi.org/10.1016/j.bbrc.2019.02.100, 511, 916-920, 2019.06.
6. Yuko Katoh-Fukui, Takashi Baba, Tetsuya Sato, Hiroyuki Otake, Yuko Nagakui-Noguchi, Miyuki Shindo, Mikita Suyama, Yasuyuki Ohkawa, Hideki Tsumura, Ken-ichirou Morohashi, Maki Fukami , Mouse polycomb group gene Cbx2 promotes osteoblastic but suppresses adipogenic differentiation in postnatal long bones, Bone, DOI: 10.1016/j.bone.2018.10.021 2018, 120, 219-231, 2018.06.
7. Takashi Baba, Hiroyuki Otake, Miki Inoue, Tetsuya Sato, Yasuhiro. Ishihara, Ju-Yeon Moon, Megumi Tsuchiya, Kanako Miyabayashi, Hidesato Ogawa, Yuichi Shima, Lixiang Wang, Ryuichiro Sato, Takeshi Yamazaki, Mikita Suyama, Masatoshi Nomura, Man-Ho Choi, Yasuyuki Ohkawa, Ken-ichirou Morohashi, Ad4BP/SF-1 regulates cholesterol synthesis to boost the production of steroids., Communications Biology, 10.1038/s42003-018-0020-z, 2018, 2018.06.
8. Typhanie Dumontet, Isabelle Sahut-Barnola, Amandine Septier, Nathanaelle Montanier, Ingrid Plotton, Florence Roucher-Boulez, Veronique Ducros, Anne-Marie Lefrançois-Martinez, Jean-Christophe Pointud, Mohamad Zubair, Ken-ichirou Morohashi, David Breault, Pierre Val, Antoine Martinez, PKA signalling drives zonal conversion within adult adrenocortical lineage in a sexually dimorphic manner, JCI insight, 10.1172/jci.insight.98394, 2018.06.
9. Miki Inoue, Takashi Baba, and Ken-ichirou Morohashi, Recent progress in understanding the mechanisms of Leydig cell differentiation, Mol Cell Endocrinol, http://doi.prg/10.1016/j.mce.2017.12.013, 2017.06.
10. Yewei Xing, Ken-ichirou Morohashi, Holley A. Ingraham, and Gary D. Hammer, Timing of adrenal regression by synergistic interaction between Sf1 SUMOylation and Dax1., Development , 144, 3798-3807, 2017.06.
11. Yuichi Shima, Ken-ichirou Morohashi, Leydig progenitor cells in fetal testis, Mol Cell Endocrinol, http://doi.org/10.1016/j.mce.2016.12.006, 445, 55-64, 2017.06.
12. Jhih-Siang Syu, Takashi Baba, Jyun-Yan Huang, Hidesato Ogawa, Chi-Han Hsieh, Jin- Xian Hu, Ting-Yu Chen, Tzu-Chien Lin, Ken-Ichirou Morohashi, Bu-Miin Huang, Fu-I Lu, and Chia-Yih Wang , Lysosomal activity maintains Ad4BP/SF-1 protein stability for proper steroidogenic cell growth, 10.1038/s41598-017-00393-4, 7, 2017.06.
13. Bing Li, Takashi Baba, Kanako Miyabayashi, Tetsuya Sato, Yuichi Shima, Daisuke Miura, Yasuyuki Ohkawa, Mikita Suyama, and Ken-ichirou Morohashi, Role of Ad4BP/SF-1 in regulating NADPH production in Y-1 cells, Endocrine J, 64, 315-324, 2017.06.
14. Kanako Miyabayashi, Yuichi Shima, Miki Inoue, Tetsuya Sato, Takashi Baba Yasuyuki Ohkawa, Mikita Suyama, Ken-ichirou Morohashi, Alterations in fetal Leydig cell gene expression during fetal and adult development , Sexual Development, https://doi.org/10.1159/000453323, 11, 53-63, 2017.06.
15. Yurina Shishido, Takashi Baba, Tetsuya Sato, Yuichi Shima, Kanako Miyabayashi, Miki Inoue, Haruhiko Akiyama, Hiroshi Kimura, Yoshiakira Kanai, Yasuhiro Ishihara, Shogo Haraguchi, Akira Miyazaki, Damjana Rozman, Takeshi Yamazaki, Man-Ho Choi, Yasuyuki Ohkawa, Mikita Suyama, Ken-ichirou Morohashi, Differential lactate and cholesterol synthetic activities in XY and XX Sertoli cells

, Scientific Rep, 10.1038/srep41912, 2017, 7, 2017.06.
16. Maki Igarashi, Kei Takasawa, Akiko Hakoda, Junko Kanno, Shuji Takada, Mami Miyado, Takashi Baba, Ken-ichirou Morohashi, Toshihiro Tajima, Kenichiro Hata, Kazuhiko Nakabayashi, Yoichi Matsubara, Ryohei Sekido, Tsutomu Ogata, Kenichi Kashimada, Maki Fukami, Identical NR5A1 missensemutations in two unrelated 46,XX individuals with testicular tissues, Human Mutation, 10.1002/humu.23116, 38, 39-42, 2017.06.
17. Takashi Umehara, Ikko Kawashima, Tomoko Kawai, Yumi Hoshino, Ken-ichirou Morohashi, Yuichi Shima, Wenxian Zeng, JoAnne S. Richards, Masayuki Shimada , LH-induced neuregulin (NRG1) regulates stage specific proliferation and survival of Leydig cells during testis development to impact androgen production and spermatogenesis in adult mice
, Endocrinology , 10.1210/en.2016-1478, 157, 4899-4913, 2016.06.
18. Miki Inoue, Yuichi Shima, 宮林 香奈子, Sato Tetsuya, 馬場 崇, 大川 恭行, Haruhiko Akiyama, M. Suyama, Ken-ichirou Morohashi, Isolation and characterization of mouse fetal Leydig progenitor cells , Endocrinology, DOI: http://dx.doi.org/10.1210/en.2015-1773, 157, 1222-1233, 2016.03.
19. Sawako Matsuzaki, Yuichi Shima, 宮林 香奈子, 大竹 博之, 馬場 崇, Ilpo Huhtaniemi, Ken-ichirou Morohashi, Fetal Leydig Cells are Androgen Independent and Persist as an Androgen-independent Subpopulation in the Postnatal Testis, Molecular Endocrinology, http://dx.doi.org/10.1210/me.2015-1200, 2015.12.
20. 宮林 香奈子, Kaori Tokunaga, 大竹 博之, 馬場 崇, 嶋 雄一, 諸橋 憲一郎, Heterogeneity of ovarian theca and interstitial gland cells in mice, PLoS one, doi:10.1371/journal.prone.0128352, e0128352, 2015.04.
21. Atsushi Yokoyama, Katsuhide Igarashi, 佐藤 哲也, Kiyoshi Takagi, Yurina Shishido, 馬場 崇, Ryo Ito, Jun Kanno, 大川 恭行, 諸橋 憲一郎, Akira Sugawara, Identification of Myt1 as a Subunit of the Neural Cell Type-specific LSD1 Complex, J Biol Chem, doi:10.1074/jbc.M114.566448, 289, 18152-18162, 2014.05.
22. Takashi Baba, 大竹 博之, Sato Tetsuya, 宮林 香奈子, 宍戸 祐里菜, Chia-Yih Wang, Yuichi Shima, Hiroshi Kimura, Mikako Yagi, Yasuhiro Ishihara, Shinjiro Hino, Hidesato Ogawa, Mitsuyoshi Nakao, Takeshi Yamazaki, Dongchon Kang, Yasuyuki Ohkawa, Mikita Suyama, Bon-chu Chung, Ken-ichirou Morohashi, Glycolytic genes are targets of the nuclear receptor Ad4BP/SF-1, NATURE COMMUNICATIONS, 10.1038/ncomms4634, 5, 2014.04.
23. Yuka Fujimoto, Satomi S. Tanaka, Yasuka L. Yamaguchi, Hiroki Kobayashi, Shunsuke Kuroki, Makoto Tachibana, Mai Shinomura, Yoshiakira Kanai, Ken-ichirou Morohashi, Kiyoshi Kawakami, Ryuichi Nishinakamura, Homeoproteins Six1 and Six4 Regulate Male Sex Determination and Mouse Gonadal Development, DEVELOPMENTAL CELL, 10.1016/j.devcel.2013.06.018, 26, 4, 416-430, 2013.08.
24. Kyoko Harikae, Kento Miura, Mai Shinomura, Shogo Matoba, Ryuji Hiramatsu, Naoki Tsunekawa, Masami Kanai-Azuma, Masamichi Kurohmaru, Ken-ichirou Morohashi, Yoshiakira Kanai, Heterogeneity in sexual bipotentiality and plasticity of granulosa cells in developing mouse ovaries, J Cell Sci, 126, 2834-2844, 2013.06.
25. 宮林 香奈子, Yuko Katoh-Fukui, Hidesato Ogawa, Takashi Baba, Yuichi Shima, Boriyuki Sugiyama, Kunio Kitamura, Ken-ichirou Morohashi, Aristaless related homeobox gene, Arx, is implicated in mouse fetal Leydig cell differentiation possibly through expressing in the progenitor cells
, Plos One, 2013.07.
26. Ken-ichirou Morohashi, Takashi Baba, Minoru Tanaka, Steroid hormones and the development of reproductive organs, Sexual Development, 7, 61-79.
27. Yuichi Shima, Kanako Miyabayashi, Shogo Haraguchi, Tatsuhiko Arakawa, Hiroyuki Otake, Takashi Baba, Sawako Matsuzaki, Yurina Shishido, Haruhiko Akiyama, Taro Tachibana, Kazuyoshi Tsutsui, Ken-ichirou Morohashi, Contribution of Leydig and Sertoli cells to testosterone production in mouse fetal testes, Molecular Endocrinology, 27, 63-73, 2013.01.
28. Mami Miyado, Michiko Nakamura, Kenji Miyado, Ken-ichirou Morohashi, Shinichiro Sano, Eiko Nagata, Maki Fukami, Tsutomu Ogata, Mamld1 deficiency significantly reduces mRNA expression levels of multiple genes expressed in mouse fetal Leydig cells but permits normal genital and reproductive development, Endocrinology , 153, 6033-6040.
29. Takeshi Nakamura, Shinichi Miyagawa, Yoshinao Katsu, Hajime Watanabe, Takeshi Mizutani, Tomomi Sato, Ken-ichirou Morohashi, Takashi Takeuchi, Taisen Iguchi , WNT family genes and their modulation in the ovary-independent and persistent vaginal epithelial cell proliferation and keratinization induced by neonatal diethylstilbesterol exposure in mice
, Toxicology, 296, 13-19, 2012.08.
30. Yuko Katoh-Fukui, Kanako Miyabayashi, Tomoko Komatsu, Akiko Owaki, Takashi Baba, Yuichi Shima, Tomohide Kidokoro, Yoshiakira Kanai, Andreas Schedl, Dagmar Wilhelm, Peter Koopman, Yasushi Okuno, Ken-ichirou Morohashi, Cbx2, a polycomb group gene, is required for Sry gene expression in mice., Endocrinology, doi:10.1210/en.2011-1055, 153, 913-924, 2012.08.
31. Yuichi Shima, Kanako Miyabayashi, Takashi Baba, Hiroyuki Otake, Sanae Oka, Mohamad Zubair, Ken-ichirou Morohashi, Identification of enhancer specific for fetal Leydig cells in Ad4BP/SF-1 gene., Endocrinology , doi:10.1210/en.2011-1407, 153, 417-425, 2012.08.
32. Erling A. Hoivik, Trine E. Bjanesoy, Oliver Mai, Shiki Okamoto, Yasuhiko Minokoshi, Yuichi Shima, Ken-ichirou Morohashi, Ulrich Boehm, and Marit Bakke, DNA methylation of intronic enhancers directs tissue-specific expression of Steroidogenic Factor 1/Adrenal 4 Binding Protein (SF-1/Ad4BP)., Endocrinology , 152, 2100-2110, 2011.04.
33. Hidesato Ogawa, Tomoko Komatsu, Yasushi Hiraoka, and Ken-ichirou Morohashi, Transcriptional suppression by transient recruitment of ARIP4 to sumoylated nuclear receptor Ad4BP/SF-1., Mol Biol Cell, 20, 4235-4245, 2009.10.
34. Mohamad Zubair, Sanae Oka, Keith L. Parker, and Ken-ichirou Morohashi, Transgenic expression of Ad4BP/SF-1 in fetal adrenal progenitor cells leads to ectopic adrenal formation., Mol Endocrinol, 23, 1657-1667, 2009.10.
35. Chikako Yokoyama, Tomoko Komatsu, Hidesato Ogawa, Ken-ichirou Morohashi, Masayuki Azuma, and Taro Tachibana, Generation of rat monoclonal antibodies specific for Ad4BP/SF-1., Hybridoma , 28, 113-119, 2009.10.
36. Ryuji Hiramatsu, Shogo Matoba, Masahiko Fujisawa, Masami Kanai-Azuma, Naoki Tsunekawa, Masamichi Kurohmaru, Ken-ichirou Morohashi, Dagmar Wilhelm, Peter Koopman, Yoshiakira Kanai, A critical time window of Sry action in gonadal sex determination., Development, 136, 129-138, 2009.01.
37. Mohamad Zubair, Keith L. Parker, and Ken-ichirou Morohashi, Developmental links between fetal and adult adrenal cortex revealed by lineage tracing. , Mol Cell Biol , 28, 7030-7040, 2008.10.
38. Yuko Sato, Takashi Baba, Mohamad Zubair, Kanako Miyabayashi, Yoshiro Toyama, Mamiko Maekawa, Akiko Owaki, Hirofumi Mizusaki1, Tatsuya Sawamura, Kiyotaka Toshimori, Ken-ichirou Morohashi, and Yuko Katoh-Fukui, Importance of forkhead transcription factor Fkhl18 for development of testicular vasculature, Mol. Repro. Dev. , Vol.75 , in press, 2008.08.
39. Yuichi Shima, Mohamad Zubair, Tomoko Komatsu, Sanae Oka, Chikako Yokoyama, Taro Tachibana, Tord A Hjalt, and Ken-ichirou Morohashi, Pitx2 directly regulates Ad4BP/SF-1 gene transcription in the pituitary gonadotrope via interaction with the intronic enhancer, Mol. Endocrinol. , Vol. 22, in press, 2008.08.
40. Noriko Sakai, Hiromi Terami, Shinobu Suzuki, Megumi Haga, Ken Nomoto, Nobuko Tsuchida, Ken-ichirou Morohashi, Naoaki Saito, Maki Asada, Megumi Hashimoto, Daisuke Harada, Hiroshi Asahara, Tetsuya Ishikawa, Fumiki Shimada, Kazuhiro Sakurada, Identification of NR5A1 (SF-1/AD4BP) gene expression modulators by large-scale gain and loss of function studies. , J Endocrinol 198, 489-497, 2008.07.
41. Takashi Baba, Yuichi Shima, Junsei Mimura, Motohiko Oshima, Yoshiaki Fujii-Kuriyama, and Ken-ichirou Morohashi , Involvement of aryl hydrocarbon receptor (AhR) in maintenance of seminal vesicle through sexually different target gene expression, Sex Dev , Vol. 2, No. 1, 1-11, 2008.04.
42. Yoshiyasu Ishimaru, Tomoko Komatsu, Megumi Kasahara, Yuko Katoh-Fukui, Yoshiro Toyama, Mamiko Maekawa, Kiyotaka Toshimori, Roshantha A. S. Chandraratna, Ken-ichirou Morohashi, and Hidefumi Yoshioka, Mechanism of asymmetric ovarian development in chick embryos, Development, Vol. 135, No. 4, 677-685, 2008.02.
43. Maki Fukami, Yuka, Wada, Michiyo Okada, Fumiko Kato, Noriyuki Katsumata, Takashi Baba, Ken-ichirou Morohashi, Jocelyn Laporte, Motoo Kitagawa, and Tsutomu Ogata, Mastermind-like domain containing 1 (MAMLD1 or Cxorf6) transactivates the Hes3 promoter, augments testosterone production, and contains the SF1 target sequence, J. Biol. Chem., Vol. 283, No. 9, 5525-5532, 2008.02.
44. Hiromi Kurokawa, Daisuke Saito, Yuko Katoh-Fukui, Kohei Ohta, Takashi Baba, Ken-ichirou Morohashi, Minoru Tanaka, Germ cells are essential for sexual dimorphism in the medaka gonad, PNAS, 104, (42), 16958-16963, 2007.10.
45. Yuki Ohmuro-Matsuyama, Kataaki Okubo, Masaru Matsuda, Shigeho Ijiri, Deshou Wang, Guijun Guan, Taiga Suzuki, Makoto Matsuyama, Ken-ichirou Morohashi, and Yoshitaka Nagahama, Liver receptor homologue-1 (LRH-1) activates the promoter of brain aromatase (cyp19a2) in a teleost fish, the medaka, Oryzias latipes, Mol. Repro. Dev. , Vol. 74, No.9 , 1065-1071, 2007.09.
46. WuQiang Fan, Toshihiko Yanase, Hidetaka Morinaga, Shigeki Gondo, Taijiro Okabe, Masatoshi Nomura, Tomoko Komatsu, Ken-Ichirou Morohashi, Tyrone B. Hayes, Ryoichi Takayanagi and Hajime Nawata, Atrazine-induced aromatase expression is SF-1-dependent: Implications for endocrine disruption in wildlife and reproductive cancers in humans, Environmental Health Perspectives , 115(5), 720-727, 2007.05.
47. Yoshiyuki Kojima, Yutaro Hayashi, Kentaro Mizuno, Shoichi Sasaki, Yuko Fukui, Peter Koopman, Ken-Ichiro Morohashi and Kenjiro Kohri, Up-regulation of SOX9 in human sex-determining region on the Y chromosome (SRY)-negative XX males, Clin. Endocrinol., Vol. 68, No. 5, 791-799, 2007.05.
48. De-Shou Wang, Tohru Kobayashi, Lin-Yan Shou, Yuki Ohmuro-Matsuyama, Gui-Jun Guan, Shigeho Ijiri, Funie Sakai, Masaru Matsuda, Yasushi Shibata, Kataaki Okubo, Ken-chirou Morohashi, and Yoshitaka Nagahama, Foxl2 up-regulates aromatase gene transcription in a female-specific manner by binding to the promoter as well as interacting with Ad4BP/SF-1, Mol. Endocrinol. , 21(3), 712-725, 2007.03.
49. Naoko Sato, Yusuke Kamachi, Hisato Kondoh, Yuichi Shima, Ken-ichirou Morohashi, Reiko Horikawa and Tsutomu Ogata, Hypogonadotropic hypogonadism in an adult female with a heterozygous hypomorphic mutation of SOX2, Eur. J. Endocrinol. , 156(2), 169-173, 2007.02.