九州大学 研究者情報
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基本情報 研究活動 教育活動 社会活動 病院臨床活動
藤吉 哲宏(ふじよし てつひろ) データ更新日:2020.04.28



研究業績
主要著書
主要原著論文
1. 藤吉 哲宏、平野 勝也、平野 真弓、西村 淳二、高橋 成輔、金出 英夫, Plasmin Induces Endothelium-Dependent Nitric Oxide-Mediated Relaxation in the Porcine Coronary Artery, Arteriosclerosis, Thrombosis, and Vascular Biology, 2007.04, [URL].
主要学会発表等
1. Tetsuhiro Fujiyoshi, Erico Shinjo, Kaoru Umehara, Kengo Hayamizu, Kentaro Tokuda and Yuji Karashima, A case of transient increased central venous pressure during kidney transplantation, American Society of Anesthesiologist, 2018.10.
2. Tetsuhiro Fujiyoshi, Shoko Taguchi, Jun Maki, Yoshimasa Motoyama, Kozaburo Akiyoshi, Sumio Hoka, A Case Of Severe Peripartum Cardiomyopathy , Amerian Society of Anesthesiologist, 2017.10, Peripartum cardiomyopathy (PPCM) is a severe heart failure that is developed in a healthy woman without any history of cardiac disease. The pathology is similar to dilated cardiomyopathy. PPCM was informed in 1971 by Dr. Demakis, has no prognostic factors nor diagnosis criteria, although the mortality of severe case is high. We show a case of severe PPCM in our hospital.
A case is a Japanese 36-year-old female, 157 cm of height and 70 kg of body weight (50 kg before pregnancy). She has healthy 6 kids and there is no abnormal data of perioperative findings, except for moderate pregnancy-induced hypertension (PH). Cesarean section for Full-term delivery was planned by combined spinal and epidural anesthesia.
She came to an operation room on foot with no complain. When she laid down on the bed, she felt moderate dyspnea. She was hard to keep lateral position for spinal anesthesia and general anesthesia was performed. Her baby was perfectly delivered in a 10 minutes after general anesthesia induction. After delivery, percutaneous saturation of oxygen decreased below 90 % and airway pressure increased. Crackles was pointed out by auscultation and foamy sputum was suctioned from the tracheal tube. Ejection fraction of left ventricular (LVEF) was 40 % by ultrasound echography. She was unexpectedly transferred to intensive care unit. Cardiac output was decreasing and it was hard to improve hypotension, even using circulation support drugs, and intra-aortic balloon pumping device (IABP) was inserted. Cardiac function did not improve and we discussed about percutaneous cardio-pulmonary support and left ventricular assist device, include heart transplantation and we informed to her family. Fortunately, cardiac output was improving on POD1. Blood pressure improved without any drug and IABP, although LVEF was low. Severe lung edema was improved and mechanical ventilation was removed. She discharged on POD10 and she didn’t have any symptom of cardiac failure, although LVEF didn’t full-recovered.
This case recovered with intensive circulation support from unexpected PPCM. PPCM is rare, but it causes severe and refractory cardiac dysfunction. Although some risk factors of PPCM, PH, human race and obesity, were defined, it is hard to predict PPCM before pregnancy and delivery. We should consider that Healthy and no-risk expectant mother potentially become PPCM. .
3. Fujiyoshi Tetsuhiro, Inhibition of pro-inflammatory enzyme soluble epoxide
hydrolase exerts a neuro-protective effect after cardiac
arrest and cardio-pulmonary resuscitation in mice, European society of Anesthesia, 2013.06, Many survivors have neurologic deficits after cardiac arrest and cardio-pulmonary resuscitation (CA/CPR). Memory deficit is one of the biggest problems to be solved
for them. Inflammation damages neurons and exacerbates outcome following partial brain ischemia. Activation of microglia, the brain resident immune cells,
contributes to brain injury in brain stroke mice model. However, the role of microglial activation for neuronal damage after global ischemia during CA/CPR is not well
defined. Inhibition of pro-inflammatory soluble epoxide hydrolase (sEH) reduces infarct size after stroke. We tested whether therapeutic inhibition of sEH after CA/CPR
can reduce microglial activation and neuronal death, and improve memory function.
CA/CPR causes microglia activation and neuron death in hippocampus CA1 area. sEH-inhibitor accelerates microglia activation and suppresses
neuron death. Hippocampus-dependent memory dysfunction after CA/CPR is partially protected by sEH-inhibitor administration. We indicate that sEH-inhibition is a
promising new therapeutic approach to reduce neuronal death and improve memory function after global ischemia
.
4. Fujiyoshi Tetsuhiro, Plasmin Induces Endothelium-dependent Nitric Oxide-mediated Relaxation in Coronary Artery, American sociaty of Anesthesiology, 2007.10.
5. 藤吉 哲宏、平野 真弓、平野 勝也, ブタ冠動脈におけるプラスミンの血管弛緩反応について, 日本循環制御医学会, 2007.05.
6. 藤吉 哲宏、牧 盾, ブタ冠動脈において、プラスミンが引き起こす内皮依存性血管弛緩反応の機序の検討, 日本麻酔科学会第54回学術集会, 2007.06, [URL].
学会活動
所属学会名
日本循環制御学会
日本老年麻酔学会
日本神経麻酔・集中治療学会
日本小児麻酔学会
European society of Anesthesiology
European society of intensive care medicine
日本救急医学会
日本集中治療学会
臨床麻酔学会
日本麻酔科学会
学会大会・会議・シンポジウム等における役割
2015.08.29~2015.08.29, 九州ATM (Anesthesia table meeting), 司会(Moderator).
受賞
優秀演題, 日本集中治療学会九州大会, 2014.05.
研究資金
科学研究費補助金の採択状況(文部科学省、日本学術振興会)
2015年度~2017年度, 若手研究(B), 代表, 心停止心肺蘇生後に活性化される炎症系細胞が引き起こす虚血性脳神経障害の機序の解明.

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