Kyushu University Academic Staff Educational and Research Activities Database
List of Reports
Ryo Yamasaki Last modified date:2020.06.26

Associate Professor / Neurology / Neurological Institute / Faculty of Medical Sciences

1. Autoantibody in chronic inflammatory neuropathies.
2. Ryo Yamasaki, Anti-neurofascin antibody in combined central and peripheral demyelination., Clinical and Experimental Neuroimmunology, 2013.12, Neurofascin (NF), one of the cell adhesion molecules expressed in both central nervous system (CNS) and peripheral nervous system (PNS), plays important roles in developing and maintaining the neural structures. There are several subtypes of NF resulted from the post-translational modifications; NF155, 166, 180 and 186. Among them, NF155 and NF186 are expressed in the mature CNS/PNS. NF155 is present on the oligodendroglial cell surface in CNS and Schwann cell surface in PNS at the paranode, which tightly connects with contactin and caspr on the axonal surface of paranode and works as a stabilizer of the node of Ranvier. NF186 exists on the axonal surface at the node of Ranvier. NF186 is associated with voltage gated Na channels (Nav) while both NF186 and Nav are anchored by ankyrin G. NF186 contributes to clustering of Nav at the node.
Combined central and peripheral demyelination (CCPD) is an inflammatory demyelinating disorder affecting both the CNS and PNS tissues. In this condition, distinct mechanisms from multiple sclerosis (MS) or chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) are hypothesized, based on the distinctive clinical and laboratory findings. We detected anti-NF155 antibody by cell-based assay, enzyme-linked immunosorbent assay and western blot in both sera and cerebrospinal fluids of CCPD patients at high frequencies while not in patients with other neurological disease or healthy controls. I hereby summarize basic aspects and clinical significance of NFs as indispensable regulators and autoimmune target molecules.