九州大学 研究者情報
総説一覧
友清 淳(ともきよ あつし) データ更新日:2021.12.06

講師 /  九州大学病院 口腔機能修復科 口腔機能修復学講座


総説, 論評, 解説, 書評, 報告書等
1. 友清 淳, iPS細胞を基盤とする新規歯周組織再生療法開発への戦略, BIO Clinica, 2019.11.
2. 友清淳, iPS細胞の応用による神経堤細胞賦活化遺伝子を標的とした新規歯周組織再生薬の創出, プレシジョンメディスン, 2019.05.
3. Tomokiyo A, Yoshida S, Hamano S, Hasegawa D, Sugii H, Maeda H., Detection, Characterization, and Clinical Application of Mesenchymal Stem Cells in Periodontal Ligament Tissue., Stem Cells Int., 2018 Aug 26;2018:5450768. doi: 10.1155/2018/5450768. eCollection 2018., 2018.08.
4. Atsushi Tomokiyo, Naohisa Wada, Sayuri Hamano, Daigaku Hasegawa, Hideki Sugii, Shinichiro Yoshida, Hidefumi Maeda, Periodontal Ligament Stem Cells in Regenerative Dentistry for Periodontal Tissues, Journal of Stem Cell Research & Therapeutics, 2016.07, The ideal periodontal treatment is regenerating functional periodontal tissues destroyed by severe periodontitis. The tissue engineering triad includes stem cells, biological signals, and cell-seeded scaffold that are considered to be essential for tissue regeneration. Periodontal ligament (PDL) tissue contains a stem cell population, periodontal ligament stem cells (PDLSC), that is derived the neural crest tissue. PDLSC demonstrate high proliferative capacity and multipotency that make them a highly promising stem cell population for use in the regeneration of damaged periodontal tissues. Here, we review the current understanding of the features and functions of PDLSC..
5. Naohisa Wada, Atsushi Tomokiyo, Hidefumi Maeda, Future Perspectives in Dental Stem Cell Engineering and the Ethical Considerations, Dental Stem Cells Part of the series Stem Cell Biology and Regenerative Medicine pp 289-307, 2016.07, To date, when teeth are damaged or missing, they are restored or compensated by using artificial material fillings, crowns or dentures. However, because dental tissues, such as the dentin/pulp complex, periodontal tissue or whole tooth, are composed of both soft and hard tissues, their complex structures are not easy to be reconstructed. Thus, there is a great need for alternative therapies for regenerating damaged dental tissue with greater efficiency. Recently, cell-based therapies that use stem cells to facilitate tissue regeneration have been investigated for different clinical applications. To achieve tissue regeneration, many scientists and dentists believe that three elements are essential: cells, growth factors, and scaffolds, with numerous studies currently underway. There are still many unanswered questions in the development of an effective method for dental tissue engineering, such as the following. Which stem cell population is appropriate for dental tissue regeneration? What factors are needed for inducing cell differentiation into the required cell population for transplantation or for inducing dedifferentiation into stem-like cells? What is the best scaffold for tissue engineering? What ethical issues must be addressed? More recently, a number of reports have been published that have brought us closer to answering some of these questions. The development of allogeneic stem cell applications, along with the identification of stem cell-induction factors, dental tissue-derived induced pluripotent stem cells, and biomimetic scaffolds could help promote better tissue regeneration in the near future..
6. Atsushi Tomokiyo, Hynes Kim, Gronthos Stan, Naohisa Wada, Bartold Peter Mark, Is There a Role for Neural Crest Stem Cells in Periodontal Regeneration? , Current Oral Health Reports, 2015.10.
7. Hidefumi Maeda, Atsushi Tomokiyo, Naohisa Wada, Koori Katsuaki, GIICHIRO KAWACHI, Akifumi Akamine, Regeneraition of the periodontium for preservation of the damaged tooth, Hindawi Publishing Corporation, 2014.10.

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