Kyushu University Academic Staff Educational and Research Activities Database
List of Reports
Kentaro Tokuda Last modified date:2020.05.27

Assistant Professor / Intensive Care Unit, kyushu University Hospital / Intensive Care Unit / Kyushu University Hospital

1. , [URL].
2. Hydrogen sulfide, known as a toxic gas with a characteristic rotten-egg odor, is produced in mammalian cells by sulfurtransferases in several ways. Hydrogen sulfide has been proved to act as one of gaseous signaling molecules together with nitric oxide and carbon monoxide regulating pathophysiological as well as physiological functions. Recently, hydrogen sulfide and its donors have been reported to exert various organ-protective effects in experimental settings. Proposed mechanisms by which hydrogen sulfide exhibits beneficial effects include anti-inflammation, anti-apoptosis, anti-oxidation, neuromodulation, and so on. Firstly, this review describes the history of hydrogen sulfide research. Second, physiological concentration of sulfide and its measurement are argued. To deliver hydrogen sulfide to the cells, not only hydrogen sulfide gas, which is a potentially toxic, but also hydrogen sulfide donors without toxic gas poisoning can be administered. Therefore, the development of novel hydrogen sulfide-releasing compounds is discussed in the end. This review is intended to introduce hydrogen sulfide not as a stinky gas but as a promising molecule with various therapeutic properties to clinicians. .
3. Anesthetic management of the patient with congestive heart faiure.