Kyushu University Academic Staff Educational and Research Activities Database
List of Reports
Takeshi Yokoyama Last modified date:2021.06.28

Professor / Maxillofacial Diagnostic and Surgical Sciences / Department of Dental Science / Faculty of Dental Science

1. Takashi Hitosugi, Takeshi Mitsuyasu, Takeshi Yokoyama, Cleft-lip-plate patient with tracheobronchomalacia: A case report and review of the literature in Japan, JPRAS Open. Volume 26, December 2020, Pages 60-68,, 2020.09, The study describes a case of cleft-lip-plate (CL/P) in a 7-month-old Japanese female with TBM and Tetralogy of Fallot syndrome. Before undergoing cleft-lip surgery, her TBM was not fully elucidated by preoperative examinations, and the operation was completed uneventfully. After the surgery, however, she started showing severe respiratory distress and developed hypoxia and bradycardia in the operating room. CPR was performed successfully, but a bronchoscopy revealed a severely collapsed airway, and the pathological condition was diagnosed as TBM occurred postoperatively. Eight months later, she died of sudden respiratory failure similar to that of the postoperative event caused by TBM. A literature review was conducted on the complications of CL/P from 1990 to 2017 in Japan.
It was hypothesized that CL/P with congenital heart disease (CHD) and TBM with CHD may crossover in relatively high rates. Currently, there are very few solutions available to treat severe airway obstruction related to TBM. This highlights the need for preoperative diagnosis of TBM as an important step in overcoming severe airway complications.
TracheobronchomalaciaCleft-lip-plateCongenital heart diseaseGeneral anesthesia.
2. Hitosugi T, Tsukamoto M, Yokoyama T., Pneumonia due to aspiration of povidine iodine after preoperative disinfection of the oral cavity., Oral Maxillofac Surg. 2019 Dec;23(4):507-511. , doi: 10.1007/s10006-019-00800-2., 2019.12.
3. Nagano S, Tsukamoto M, Yokoyama T., Anesthetic management of a patient with Fanconi anemia., Anesth prog in press, 2019.12.
4. Masanori Tsukamoto, Shiori Taura, Hitoshi Yamanaka, Takeshi Yokoyama. , General Anesthesia for Pediatric Patients with Leukemia. SN Comprehensive Clinical Medicine 2019;1:650–654., SN Comprehensive Clinical Medicine 2019;1:650–654., 2019.09, Pediatric leukemia is a common cause of disease-related fatality in children aged 1 to 10 years. This disease is usually treated with a combination of chemotherapy, radiation therapy, and bone marrow transplantation. With advancements in cancer treatment, approximately 70–80% of pediatric cancer patients have been cured with these aggressive combination therapies. However, oral and dental infection, mucositis, and necrosis of tissues can occur during the cancer treatment, which may lead to morbidity and an inferior quality of life for pediatric patients with leukemia. Early detection and radical treatment reduce the risk of oral infection and its associated systemic complications. Moreover, dental treatment such as extraction or preventive treatment of teeth should be considered before the start of the cancer treatment. However, it is difficult to provide dental treatment to pediatric patients with leukemia in usual settings due to their uncooperative behavior and/or the presence of psychiatric disorders. Therefore, general anesthesia during dental treatment is often recommended for these patients. In this paper, we reviewed the anesthetic management and perioperative complications in pediatric patients with leukemia receiving general anesthesia..
5. Hosokawa R, Tsukamoto M, Nagano S, Yokoyama T., Anesthetic Management of a Patient With Hereditary Angioedema for Oral Surgery., Anesth Prog. 2019 Spring;66(1):30-32., doi: 10.2344/anpr-65-04-01., 2019.04, Hereditary angioedema (HAE) is a rare genetic disease that results from deficiency or dysfunction of C1 inhibitor (C1-INH). This disease is characterized by sudden attacks of angioedema. When edema occurs in the pharynx or larynx, it can lead to serious airway compromise, including death. Physical and/or psychological stress can trigger an attack. Dental treatment, including tooth extraction, is also a recognized trigger. We report a case of a 20-year-old male with HAE who required impacted third molar extractions. C1-INH concentrate was administered 1 hour before surgery, which was completed under deep intravenous sedation. This report describes the anesthetic management of a patient with HAE and reviews treatment options and concerns..
6. Tsukamoto M, Hitosugi T, Yamanaka H, Yokoyama T., Bifid epiglottis, high-arched palate, and mental disorder in a patient with Pallister-Hall syndrome, Indian J Anaesth. 2018 Oct;62(10):825-827., 10.4103/ija.IJA_317_18., 2018.10.
7. Tsukamoto M, Hitosugi T, Yokoyama T., Awake fiberoptic nasotracheal intubation for patients with difficult airway., J Dent Anesth Pain Med. 2018 Oct;18(5):301-304., doi: 10.17245/jdapm.2018.18.5.301., 2018.10, Awake fiberoptic nasotracheal intubation is a useful technique, especially in patients with airway obstruction. It must not only provide sufficient anesthesia, but also maintain spontaneous breathing. We introduce a method to achieve this using a small dose of fentanyl and midazolam in combination with topical anesthesia. The cases of 2 patients (1 male, 1 female) who underwent oral maxillofacial surgery are reported. They received 50 µg of fentanyl 2-3 times (total 2.2-2.3 µg/kg) at intervals of approximately 2 min. Oxygen was administered via a mask at 6 L/min, and 0.5 mg of midazolam was administered 1-4 times (total 0.02-0.05 mg/kg) at intervals of approximately 2 min. A tracheal tube was inserted through the nasal cavity after topical anesthesia was applied to the epiglottis, vocal cords, and into the trachea through the fiberscope channel. All patients were successfully intubated. This is a useful and safe method for awake fiberoptic nasotracheal intubation..
8. Tsukamoto M, Hirokawa J, Yokoyama T., Retained Foreign Body in the Nasal Cavity After Oral Maxillofacial Surgery., Anesth Prog. 2018 Summer;65(2):111-112., doi: 10.2344/anpr-65-01-07., 2018.08.
9. Tsukamoto M, Hitosugi T, Yamanaka H, Yokoyama T., Postoperative Alopecia Following Oral Surgery., J Oral Maxillofac Surg. 2018 Nov;76(11):2318.e1-2318.e3., doi: 10.1016/j.joms.2018.07.011., 2018.07, Postoperative alopecia is an uncommon complication and its outcome is an esthetically drastic change. Although its mechanism has not been clearly reported, risk factors might be positioning and prolonged operative time during oral surgeries. In addition, perioperative stressful conditions might influence the biological clock of the hair cycle. This report presents 2 cases of postoperative alopecia after oral surgery. Prevention of alopecia with type of headrest, change in head positioning, and avoidance of continuous compression is important..
10. Tsukamoto M, Hirokawa J, Hitosugi T, Yokoyama T., Airway Management for a Pediatric Patient with a Tracheal Bronchus., Anesth Prog. Spring 2018;65(1):50-51., doi: 10.2344/anpr-64-04-02., 2018.01.
11. Takashi Hitosugi, Masanori Tsukamoto, Jun Hirokawa, Takeshi Yokoyama, In dental office, supine abdominal thrust is recommended as an effective relief for asphyxia due to aspiration, American Journal of Emergency Medicine, 2017.12.
12. Takeshi Yokoyama, IppeiYamaoka, Takashi Hitosugi, Eva Sellden, Amino Acids during Perioperative Period, Open Journal of Anesthesiology, DOI: 10.4236/ojanes.2017.79029 , 2017.09.
13. Takeshi Yokoyama, Masanori Tsukamoto, Jun Hirokawa, Effective spray for topical anesthesia with fiberscope, Journal of Anesthesia, 2017.09.
14. Masanori Tsukamoto, Jun Hirokawa, Takeshi Yokoyama, Airway management with a rigid external distractor in place, Indian Journal of Anaesthesia, 2017.08.
15. Masanori Tsukamoto, Jun Hirokawa, Takeshi Yokoyama, Airway spray efficacy of local anesthetic with fiberscope, Journal of Anesthesia, 2017.04.
16. Saori Morinaga, Masanori Tsukamoto, Takeshi Yokoyama, Anesthetic management of a patient with duplication of chromosome 6p, Journal of Dental Anesthesia and Pain Medicine, 2017.02.
17. Masanori Tsukamoto, Takashi Hitosugi, Takeshi Yokoyama, Airway management by flexible laryngeal mask airway with difficult intubation for dental treatment, Journal of Dental Anesthesia and Pain Medicine, 2017.01.
18. 横山武志, 細井昌子, 坂本英治, 歯科における慢性痛 : 三叉神経障害関連の医療トラブルにおける寄与因子は何か? (シンポジウム 生物心理社会モデルに基づいた痛みに対する科学的アプローチ) , 日本運動器疼痛学会誌, 2016.02.
19. Hiroko Fujino, Takeshi Yokoyamaa, Kazu-ichi Yoshidab and Kunio Suwa, Reply to: Chest compression: Not as effective on dental chair as on the floor , Resuscitation. 2010;81(12):1729; author reply 1730., 2010.12.
20. Perioperative control of glucose metabolism.
21. Fujino H, Yokoyama T, Yoshida KI, Suwa K, Using a stool for stabilization a dental chair when CPR is required, Resuscitation. 2010;81(4):502., 2010.01.
22. Yatabe T, Yokoyama T, Yamashita K, Okabayashi T, Hanazaki K., Increase in blood glucose with the start of the reperfusion after large vessel surgery., Anesth Analg. 2009 Aug;109(2):684. , 2009.08.