甘味受容体と味覚修飾物質に関する研究
キーワード：甘味受容体、味覚修飾物質、ヒト、マウス
2009.05.
| 實松 敬介（さねまつ けいすけ） | データ更新日：2023.11.22 |
主な研究テーマ
研究業績
主要著書
主要原著論文
| 1. | Sanematsu K, Yamamoto M, Nagasato Y, Kawabata Y, Watanabe Y, Iwata S, Takai S, Toko K, Matsui T, Wada N, Shigemura N, Prediction of dynamic allostery for the transmembrane domain of the sweet taste receptor subunit, TAS1R3., Communications Biology, 10.1038/s42003-023-04705-5, 6, 1, 340, 2023.04. |
| 2. | Osaki, Ayana; Sanematsu, Keisuke; Yamazoe, Junichi; Hirose, Fumie; Watanabe, Yu; Kawabata, Yuko; Oike, Asami; Hirayama, Ayaka; Yamada, Yu; Iwata, Shusuke; Takai, Shingo; Wada, Naohisa; Shigemura, Noriatsu, Drinking Ice-Cold Water Reduces the Severity of Anticancer Drug-Induced Taste Dysfunction in Mice, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 10.3390/ijms21238958, 21, 23, 2020.12. |
| 3. | Keisuke Sanematsu, Yuki Nakamura, Masatoshi Nomura, Noriatsu Shigemura, Yuzo Ninomiya, Diurnal variation of sweet taste recognition thresholds is absent in overweight and obese humans, Nutrients, 10.3390/nu10030297, 10, 3, 2018.03, [URL], Sweet taste thresholds are positively related to plasma leptin levels in normal weight humans: both show parallel diurnal variations and associations with postprandial glucose and insulin rises. Here, we tested whether this relationship also exists in overweight and obese (OW/Ob) individuals with hyperleptinemia. We tested 36 Japanese OW/Ob subjects (body mass index (BMI) > 25 kg/m2 ) for recognition thresholds for various taste stimuli at seven different time points from 8:00 a.m. to 10:00 p.m. using the staircase methodology, and measured plasma leptin, insulin, and blood glucose levels before each taste threshold measurement. We also used the homeostatic model assessment of insulin resistance (HOMA-IR) to evaluate insulin resistance. The results demonstrated that, unlike normal weight subjects, OW/Ob subjects showed no significant diurnal variations in the recognition thresholds for sweet stimuli but exhibited negative associations between the diurnal variations of both leptin and sweet recognition thresholds and the HOMA-IR scores. These findings suggest that in OW/Ob subjects, the basal leptin levels (~20 ng/mL) may already exceed leptin’s effective concentration for the modulation of sweet sensitivity and that this leptin resistance-based attenuation of the diurnal variations of the sweet taste recognition thresholds may also be indirectly linked to insulin resistance in OW/Ob subjects.. |
| 4. | Keisuke Sanematsu, Noriatsu Shigemura, Yuzo Ninomiya, Binding properties between human sweet receptor and sweet-inhibitor, gymnemic acids, Journal of Oral Biosciences , 10.1016/j.job.2017.05.004 , 2017.05. |
| 5. | Keisuke Sanematsu, Masayuki Kitagawa, Ryusuke Yoshida, Satoru Nirasawa, Noriatsu Shigemura, Yuzo Ninomiya, Intracellular acidification is required for full activation of the sweet taste receptor by miraculin, Scientific reports, 10.1038/srep22807, 6, 22807, 2016.03. |
| 6. | Keisuke Sanematsu, Ryusuke Yoshida, Noriatsu Shigemura, Yuzo Ninomiya, Structure, function, and signaling of taste G-protein-coupled receptors, Current Pharmaceutical Biotechnology, １５, １０, 951-961, 2014.09. |
| 7. | Keisuke Sanematsu, Yuko Kusakabe, Noriatsu Shigemura, Takatsugu Hirokawa, Seiji Nakamura, Toshiaki Imoto, Yuzo Ninomiya, Molecular Mechanisms for Sweet-suppressing Effect of Gymnemic Acids, Journal of Biological Chemistry, M114.560409 [pii] 10.1074/jbc.M114.560409, 289, 37, 25711-25720, 2014.09. |
| 8. | Sanematsu K, Yasumatsu K, Yoshida R, Shigemura N, Ninomiya Y., Mouse strain differences in Gurmarin-sensitivity of sweet taste responses are not associated with polymorphisms of the sweet receptor gene, Tas1r3., Chemical Senses, 10.1093/chemse/bji041, 30, 6, 491-496, 30(6):491-6., 2005.07. |
| 9. | 實松敬介、重村憲徳、中村誠司、井元敏明、二ノ宮裕三, トリテルペン配糖体とヒト甘味受容体hT1R2/hT1R3の相互作用, 日本味と匂学会誌, 15(3) 297-300, 2008.01. |
| 10. | Sanematsu K, Horio N, Murata Y, Yoshida R, Ohkuri T, Shigemura N, Ninomiya Y., Modulation and transmission of sweet taste information for energy homeostasis., Ann N Y Acad Sci., 1170:102-6., 2009.07. |
| 11. | 實松敬介、安松啓子、吉田竜介、重村憲徳、二ノ宮裕三, Tas1r3遺伝子型とグルマリン感受性の関連, 日本味と匂学会誌, 13(3) 343-346, 2006.01. |
| 12. | 實松敬介、重村憲徳、井元敏明、二ノ宮裕三, 甘味受容体hT1R2+hT1R3強制発現系によるギムネマ酸の甘味抑制効果解析, 日本味と匂学会誌, 14(3) 375-378, 2007.01. |
主要学会発表等
学会活動
学会大会・会議・シンポジウム等における役割
2010.11.06～2010.11.07, International Symposium on Molecular and Neural Mechanisms of Taste and Olfactory Perception, 実行委員.
2011.11.05～2011.11.06, International Symposium on Molecular and Neural Mechanisms of Taste and Olfactory Perception, 実行委員.
2013.10.31～2013.11.02, International Symposium on Molecular and Neural Mechanisms of Taste and Olfactory Perception, 実行委員.
2012.11.03～2012.11.04, International Symposium on Molecular and Neural Mechanisms of Taste and Olfactory Perception, 実行委員.
受賞
2017 年度日本味と匂学会研究奨励賞（味部門）, 日本味と匂学会, 2017.09.
歯科基礎医学会学会奨励賞, 歯科基礎医学会, 2016.08.
論文賞, 日本味と匂学会, 2010.09.
研究資金
科学研究費補助金の採択状況(文部科学省、日本学術振興会)
2021年度～2023年度, 基盤研究(C), 代表, 味覚受容体の動的相互作用機構の解明.
2018年度～2020年度, 基盤研究(C), 代表, 全身に発現する味覚受容体の分子・生理・病態機能の解明.
2015年度～2017年度, 基盤研究(C), 代表, エネルギー受容センサーとしての甘味受容体解析.
2013年度～2014年度, 若手研究(B), 代表, 甘味受容体機能の解明.
2011年度～2012年度, 若手研究(B), 代表, 甘味受容体と味覚修飾物質の相互作用解析.
2011年度～2011年度, 基盤研究(A), 分担, 口腔消化管味覚センサーのシグナル調節・伝達機構の解明.
2010年度～2010年度, 基盤研究(S), 分担, 食の調節情報としての味覚の受容・機序の解明：味覚健康科学の創成.
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