均一オリゴマーライブラリーの合成とバイオ応用
キーワード：均一オリゴマー
2019.04.

CO2選択透過膜の開発
キーワード：CO2
2014.04.

タンパク質分離材料の開発
キーワード：合成高分子　分子認識　抗体
2006.06.

熱エネルギー変換用高分子材料の開発
キーワード：エネルギー変換　
2011.04.

省エネ型二酸化炭素回収剤の開発
キーワード：CO2
2011.04.

プラスチック抗体の開発
キーワード：合成高分子　分子認識　抗体
2006.06.

JAXAきぼう利用フィジビリティスタディテーマ 微小重力環境における藻類による物質循環サイクルの実現可能性検証
2017.04～2020.03, 代表者：星野友, 九州大学
微小重力環境における藻類による物質循環サイクルの実現可能性検証.

JST-ＳＴＡＲＴプロジェクト農産物の品質や生産性を向上させる為の環境制御システムの開発
2017.10～2020.03, 代表者：星野友, 九州大学
農産物の品質や生産性を向上させる為の環境制御システムの開発を行う.

JST-ALCA実用技術化プロジェクト　省エネルギー且つ低コストなCO2分離濃縮材料・プロセスの開発
2017.11～2022.03, 代表者：星野友, 九州大学
革新的なCO2分離材料およびプロセスの開発を行う.

JST-ALCA　相転移型ナノゲルのpKa制御によるCO2分離膜・プロセスの開発
2014.10～2017.10, 代表者：星野友, 九州大学
革新的なCO2分離膜の開発を行う。.

生体分子認識ナノゲルの開発
2011.09～2015.03, 代表者：星野友, 九州大学, カリフォルニア大学アーバイン校（アメリカ合衆国）、九州大学（日本）、静岡県立大学（日本）
特定の生体分子を認識するナノ粒子の開発および用途開発を行う。.

主要著書

主要原著論文

1.	Yusuke Saito, Ryutaro Honda, Sotaro Akashi, Hinata Takimoto, Masanori Nagao, Yoshiko Miura, Yu Hoshino, Polymer Nanoparticles with Uniform Monomer Sequences for Sequence Specific Peptide Recognition, Angew. Chem. Int. Ed, 10.1002/ange.202206456, e202206456, 2022.05, [URL], Synthetic polymer nanoparticles (NPs) that recognize and neutralize target biomacromolecules are of considerable interest as “plastic antibodies”, synthetic mimics of antibodies. However, monomer sequences in the synthetic NPs are heterogeneous. The heterogeneity limits the target specificity and safety of the NPs. Herein, we report the synthesis of NPs with uniform monomer sequences for recognition and neutralization of target peptides. A multifunctional oligomer with a precise monomer sequence that recognizes the target peptide was prepared via cycles of reversible addition–fragmentation chain transfer (RAFT) polymerization and flash chromatography. The oligomer or blend of oligomers was used as a chain transfer agent and introduced into poly(N-isopropyl acrylamide) hydrogel NPs by radical polymerization. Evaluation of the interaction with the peptides revealed that multiple oligomers in NPs cooperatively recognized the sequence of the target peptide and neutralized its toxicity. Effect of sequence, combination, density and molecular weight distribution of precision oligomers on the affinity to the peptides was also investigated..
2.	Yusuke Yonamine, Takuya Asai, Yuta Suzuki, Takuro Ito, Yasuyuki Ozeki, Yu Hoshino, Probing the biogenesis of polysaccharide granules in algal cells at sub-organellar resolution via Raman microscopy with stable isotope labeling, Analytical Chemistry, 10.1021/acs.analchem.1c03216, 93, 16796, 2021.12, [URL].
3.	Yu Hoshino, Tomohiro Gyobu, Kazushi Imamura, Akira Hamasaki, Ryutaro Honda, Ryoga Horii, Chie Yamashita, Yuki Terayama, Takeshi Watanabe, Shoma Aki, Yida Liu, Junko Matsuda, Yoshiko Miura, Ikuo Taniguchi, Assembly of Defect-Free Microgel Nanomembranes for CO2 Separation, ACS Applied Bio Materials, 3, 6, 2021.07.
4.	Benshuai Guo, Yoshiko Miura, Yu Hoshino, Rational design of thermocells driven by the volume phase transition of hydrogel nanoparticles, ACS Applied Materials & Interfaces, 10.1021/acsami.1c07266, 13, 32184, 2021.07, [URL].
5.	Ryutaro Honda, Akira Hamasaki, Yoshiko Miura, Yu Hoshino, Thermoresponsive CO 2 absorbent for various CO 2 concentrations: tuning the p K a of ammonium ions for effective carbon capture, Polymer Journal, 10.1038/s41428-020-00407-5, 53, 157-167, 2021.01, [URL].
6.	Benshuai Guo, Yu Hoshino, Fan Gao, Keisuke Hayashi, Yoshiko Miura, Nobuo Kimizuka, Teppei Yamada, Thermocells driven by phase transition of hydrogel nanoparticles, J. Am. Chem Soc, doi.org/10.1021/jacs.0c08600, 142, 41, 17318-17322, 2020.09, Thermoelectric conversion of low temperature, delocalized, and abundant thermal sources is crucial for the development of the Internet of Things (IoT) and/or a carbon-free society. Thermocells are of great interest in thermoelectric conversion of low-temperature heat due to the low cost and flexibility of components. However, significant improvement of the conversion efficiency is required for the practical use of the cells. Here, we report thermo-electrochemical cells driven by volume phase transition (VPT) of hydrogel nanoparticles (NPs). Entropically driven VPT of poly(N-isopropylacrylamide) NPs containing carboxylic acids and amines generates a pH gradient of up to 0.049 and −0.053 pH K–1, respectively, around physiological temperature. The pH gradient triggers the proton-coupled electron transfer (PCET) reactions of quinhydrone on the electrodes, resulting in the highly efficient thermoelectric conversion with a Seebeck coefficient (Se) of −6.7 and +6.1 mV K–1. Thermocells driven by phase transition of hydrogels provide a nontoxic, flexible, and inexpensive charger that harvests carbon-free energy from abundant energy sources such as solar, body and waste heat..
7.	Hiroyuki Koide, Anna Okishima, Yu Hoshino, Yuri Kamon, Keiichi Yoshimatsu, Kazuhiro Saito, Ikumi Yamauchi, Saki Ariizumi, Yuqi Zhou, Ting-Hui Xiao, Keisuke Goda, Naoto Oku, Tomohiro Asai, Kenneth J Shea, Synthetic hydrogel nanoparticles for sepsis therapy, Nature communications, 10.1038/s41467-021-25847-2, 12, 5552, 2020.09, [URL], Sepsis is a life-threatening condition caused by the extreme release of inflammatory mediators into the blood in response to infection (e.g., bacterial infection, COVID-19), resulting in the dysfunction of multiple organs. Currently, there is no direct treatment for sepsis. Here we report an abiotic hydrogel nanoparticle (HNP) as a potential therapeutic agent for late-stage sepsis. The HNP captures and neutralizes all variants of histones, a major inflammatory mediator released during sepsis. The highly optimized HNP has high capacity and long-term circulation capability for the selective sequestration and neutralization of histones. Intravenous injection of the HNP protects mice against a lethal dose of histones through the inhibition of platelet aggregation and migration into the lungs. In vivo administration in murine sepsis model mice results in near complete survival. These results establish the potential for synthetic, nonbiological polymer hydrogel sequestrants as a new intervention strategy for sepsis therapy and adds to our understanding of the importance of histones to this condition..
8.	Yu Hoshino, Shinnosuke Shimohara, Yusuke Wada, Masahiko Nakamoto, Yoshiko Miura, Affinity Purification of Multifunctional Oligomeric Ligands Synthesizedvia Controlled Radical Polymerization, J Mat. Chem B, doi.org/10.1039/d0tb00849d, 8, 26, 5597-5601, 2020.07.
9.	Nao Nitta, Takanori Iino, Akihiro Isozaki, Mai Yamagishi, Yasutaka Kitahama, Shinya Sakuma, Yuta Suzuki, Hiroshi Tezuka, Minoru Oikawa, Fumihito Arai, Takuya Asai, Dinghuan Deng, Hideya Fukuzawa, Misa Hase, Tomohisa Hasunuma, Takeshi Hayakawa, Kei Hiraki, Kotaro Hiramatsu, Yu Hoshino, Mary Inaba, Yuki Inoue, Takuro Ito, Masataka Kajikawa, Hiroshi Karakawa, Yusuke Kasai, Yuichi Kato, Hirofumi Kobayashi, Cheng Lei, Satoshi Matsusaka, Hideharu Mikami, Atsuhiro Nakagawa, Keiji Numata, Tadataka Ota, Takeichiro Sekiya, Kiyotaka Shiba, Yoshitaka Shirasaki, Nobutake Suzuki, Shunji Tanaka, Shunnosuke Ueno, Hiroshi Watarai, Takashi Yamano, Masayuki Yazawa, Yusuke Yonamine, Dino Di Carlo, Yoichiroh Hosokawa, Sotaro Uemura, Takeaki Sugimura, Yasuyuki Ozeki, Keisuke Goda, Raman image-activated cell sorting, Nature communications, 10.1038/s41467-020-17285-3, 11, 3452, 2020.07, [URL].
10.	Hinata Takimoto, Sho Katakami, Yoshiko Miura, Yu Hoshino, Controlling the block sequence of multi-block oligomer ligands for neutralizationof a target peptide, Materials Advances, doi.org/10.1039/DoMA00149J, 4, 604-608, 2020.06.
11.	Ryutaro Honda,Tomohiro Gyobu, Hideo Shimahara, Yoshiko Miura, Yu Hoshino, Electrostatic Interactions Between Acid-/Base-Containing Polymer Nanoparticles and Proteins: Impact of Polymerization pH, ACS Applied Bio Materials, doi.org/10.1021/acsabm.0c00390, 3, 6, 3827-3834, 2020.05.
12.	Akihiro Isozaki, Hideharu Mikami, Hiroshi Tezuka, Hiroki Matsumura, Kangrui Huang, Marino Akamine, Kotaro Hiramatsu, Takanori Iino, Takuro Ito, Hiroshi Karakawa, Yusuke Kasai, Yan Li, Yuta Nakagawa, Shinsuke Ohnuki, Tadataka Ota, Yong Qian, Shinya Sakuma, Takeichiro Sekiya, Yoshitaka Shirasaki, Nobutake Suzuki, Ehsen Tayyabi, Tsubasa Wakamiya, Muzhen Xu, Mai Yamagishi, Haochen Yan, Qiang Yu, Sheng Yan, Dan Yuan, Wei Zhang, Yaqi Zhao, Fumihito Arai, Robert E Campbell, Christophe Danelon, Dino Di Carlo, Kei Hiraki, Yu Hoshino, Yoichiroh Hosokawa, Mary Inaba, Atsuhiro Nakagawa, Yoshikazu Ohya, Minoru Oikawa, Sotaro Uemura, Yasuyuki Ozeki, Takeaki Sugimura, Nao Nitta, Keisuke Goda, Intelligent image-activated cell sorting 2.0, Lab on a Chip, 10.1039/D0LC00080A , 20, 2273, 2020.05, [URL].
13.	Yusuke Yonamine, Kotaro Hiramatsu, Takuro Ideguchi, Takuro Ito, Tomomi FujiwaraYoshiko Miura, Keisuke Goda, Yu Hoshino, Spatiotemporal monitoring of intracellular metabolic dynamics by resonanceRaman microscopy with isotope labeling, RSC Advances, doi.org/10.1039/DoRA02803G, 10, 16679-16686, 2020.04.
14.	Yu Hoshino,Mitsunori Moribe, Naoki Gondo, Toshiki Jibiki, Masahiko Nakamoto, BenshuaiGuo, Rinoka Adachi, Yoshiko Miura, Combining Acid- and Base-Imprinted Nanoparticles in a Hydrogel Film forTemperature-Responsive Quick and Reversible Capture of Salt, ACS Appl. Polym. Mater, doi.org/10.1021/acsapm.9b00940, 2, 505-514, 2020.02, [URL].
15.	Yu Hoshino, Shohei Taniguchi,Hinata Takimoto, Sotaro Akashi, Sho Katakami, Yusuke Yonamine, Yoshiko Miura, Homogeneous Oligomeric Ligands Prepared via Radical Polymerization thatRecognize and Neutralize a Target Peptide, Angew. Chem. Int. Ed, doi.org/10.1002/anie.201910558, 132, 689-693, 2020.02, [URL], Abiotic ligands that bind to specific biomolecules have attracted attention as substitutes for biomolecular ligands, such as antibodies and aptamers. Radical polymerization enables the production of robust polymeric ligands from inexpensive functional monomers. However, little has been reported about the production of monodispersed polymeric ligands. Herein, we present homogeneous ligands prepared via radical polymerization that recognize epitope sequences on a target peptide and neutralize the toxicity of the peptide. Taking advantage of controlled radical polymerization and separation, a library of multifunctional oligomers with discrete numbers of functional groups was prepared. Affinity screening revealed that the sequence specificity of the oligomer ligands strongly depended on the number of functional groups. The process reported here will become a general step for the development of abiotic ligands that recognize specific peptide sequences..
16.	Yida Liu, Takashi Kodama, Taisuke Kojima, Ikuo Taniguchi, Hirokazu Seto, Yoshiko Miura, Yu Hoshino, Fine-tuning of the surface porosity of micropatterned polyethersulfonemembranes prepared by phase separation micromolding, Polymer J, doi.org/10.1038/s41428-019-0298-9, 52, 397-403, 2020.01, [URL].
17.	Nobutoshi Ota, Yusuke Yonamine, Takuya Asai, Yaxiaer Yalikun, Takuro Ito, Yasuyuki Ozeki, Yu Hoshino, Yo Tanaka, Isolating Single Euglena gracilis Cells by Glass Microfluidics for Raman Analysis of Paramylon Biogenesis, Analytical chemistry, 10.1021/acs.analchem.9b01007, 91, 9631, 2019.07, [URL].
18.	Anna Okishima, Hiroyuki Koide, Yu Hoshino, Hiromichi Egami, Yoshitaka Hamashima, Naoto Oku, Tomohiro Asai, Design of Synthetic Polymer Nanoparticles Specifically Capturing Indole, a Small Toxic Molecule, Biomacromolecules, 10.1021/acs.biomac.8b01820, 20, 4, 1644-1654, 2019.04, [URL].
19.	Masanori Nagao, Teruhiko Matsubara,Yu Hoshino, Toshinori Sato, and Yoshiko Miura, Topological Design of Star Glycopolymers for Controlling the Interactionwith the Influenza Virus, Bioconjugate Chemistry, 10.1021/acs.bioconjchem.9b00134, 30, 1192-1198, 2019.03, [URL].
20.	Hiroyuki Koide, Keiichi Yoshimatsu, Yu Hoshino, Saki Ariizumi, Anna Okishima, Takafumi Ide, Hiromichi Egami, Yoshitaka Hamashima, Yuri Nishimura, Hiroaki Kanazawa, Yoshiko Miura, Tomohiro Asai, Naoto Oku, Kenneth J. Shea, Sequestering and inhibiting a vascular endothelial growth factor in vivo by systemic administration of a synthetic polymer nanoparticle, Journal of Controlled Release, 10.1016/j.jconrel.2018.12.033, 295, 13-20, 2019.02, [URL].
21.	Koide, H. Yoshimatsu, K. Hoshino, Y. Ariizumi, S. Okishima,A. Ide, T. Egami, H. Hamashima, Y. Nishimura, Y. Kanazawa, H. Miura, Y.Asai, T. Oku, N. Shea, K.J., Sequestering and inhibiting a vascular endothelial growth factorin vivo by systemic administration of a synthetic polymer nanoparticle , Journal of Controlled Release, Doi: 10.1016/j.jconrel.2018.12.033, 295, 13-20, 2019.02.
22.	Kotaro Hiramatsu, Takuro Ideguchi, Yusuke Yonamine, Sang Wook Lee, Yizhi Luo, Kazuki Hashimoto, Takuro Ito, Misa Hase, Jee Woong Park, Yusuke Kasai, Shinya Sakuma, Takeshi Hayakawa, Fumihito Arai, Yu Hoshino, Keisuke Goda, High-throughput label-free molecular fingerprinting flow cytometry, Science Advances, 10.1126/sciadv.aau0241, 5, 1, 2019.01, [URL].
23.	Nao Nitta, Takeaki Sugimura, Akihiro Isozaki, Hideharu Mikami, Kei Hiraki, Shinya Sakuma, Takanori Iino, Fumihito Arai, Taichiro Endo, Yasuhiro Fujiwaki, Hideya Fukuzawa, Misa Hase, Takeshi Hayakawa, Kotaro Hiramatsu, Yu Hoshino, Mary Inaba, Takuro Ito, Hiroshi Karakawa, Yusuke Kasai, Kenichi Koizumi, Sang Wook Lee, Cheng Lei, Ming Li, Takanori Maeno, Satoshi Matsusaka, Daichi Murakami, Atsuhiro Nakagawa, Yusuke Oguchi, Minoru Oikawa, Tadataka Ota, Kiyotaka Shiba, Hirofumi Shintaku, Yoshitaka Shirasaki, Kanako Suga, Yuta Suzuki, Nobutake Suzuki, Yo Tanaka, Hiroshi Tezuka, Chihana Toyokawa, Yaxiaer Yalikun, Makoto Yamada, Mai Yamagishi, Takashi Yamano, Atsushi Yasumoto, Yutaka Yatomi, Masayuki Yazawa, Dino Di Carlo, Yoichiroh Hosokawa, Sotaro Uemura, Yasuyuki Ozeki, Keisuke Goda, Intelligent Image-Activated Cell Sorting, Cell, 10.1016/j.cell.2018.08.028, 175, 1, 266-276.e13, 2018.09, [URL], A fundamental challenge of biology is to understand the vast heterogeneity of cells, particularly how cellular composition, structure, and morphology are linked to cellular physiology. Unfortunately, conventional technologies are limited in uncovering these relations. We present a machine-intelligence technology based on a radically different architecture that realizes real-time image-based intelligent cell sorting at an unprecedented rate. This technology, which we refer to as intelligent image-activated cell sorting, integrates high-throughput cell microscopy, focusing, and sorting on a hybrid software-hardware data-management infrastructure, enabling real-time automated operation for data acquisition, data processing, decision-making, and actuation. We use it to demonstrate real-time sorting of microalgal and blood cells based on intracellular protein localization and cell-cell interaction from large heterogeneous populations for studying photosynthesis and atherothrombosis, respectively. The technology is highly versatile and expected to enable machinebased scientific discovery in biological, pharmaceutical, and medical sciences..
24.	Yu Hoshino, Toshiki Jibiki, Masahiko Nakamoto, Yoshiko Miura, Reversible p Ka Modulation of Carboxylic Acids in Temperature-Responsive Nanoparticles through Imprinted Electrostatic Interactions, ACS Applied Materials and Interfaces, 10.1021/acsami.8b11397, 10, 37, 31096-31105, 2018.09, [URL].
25.	Akihiro Isozaki, Hideharu Mikami, Kotaro Hiramatsu, Shinya Sakuma, Yusuke Kasai, Takanori Iino, Takashi Yamano, Atsushi Yasumoto, Yusuke Oguchi, Nobutake Suzuki, Yoshitaka Shirasaki, Taichiro Endo, Takuro Ito, Kei Hiraki, Makoto Yamada, Satoshi Matsusaka, Takeshi Hayakawa, Hideya Fukuzawa, Yutaka Yatomi, Fumihito Arai, Dino Di Carlo, Atsuhiro Nakagawa, Yu Hoshino, Yoichiroh Hosokawa, Sotaro Uemura, Takeaki Sugimura, Yasuyuki Ozeki, Nao Nitta, Keisuke Goda, A practical guide to intelligent image-activated cell sorting, Nature protocols, 10.1038/s41596-019-0183-1, 14, 2370, 2018.08, [URL].
26.	Hiroyuki Koide, Hiroki Tsuchida, Masahiko Nakamoto, Anna Okishima, Saki Ariizumi, Chiaki Kiyokawa, Tomohiro Asai, Yu Hoshino, Naoto Oku, Rational designing of an antidote nanoparticle decorated with abiotic polymer ligands for capturing and neutralizing target toxins, Journal of Controlled Release, 10.1016/j.jconrel.2017.10.028, 268, 335-342, 2017.12, [URL].
27.	Yusuke Yonamine, Yuta Suzuki, Takuro Ito, Yoshiko Miura, Keisuke Goda, Yasuyuki Ozeki, Yu Hoshino, Monitoring Photosynthetic Activity in Microalgal Cells by Raman Spectroscopy with Deuterium Oxide as a Tracking Probe, ChemBioChem, 10.1002/cbic.201700314, 18, 20, 2063-2068, 2017.10, [URL].
28.	H. Koide, K. Yoshimatsu, Y. Hoshino, S.-H. Lee, A. Okajima, S. Ariizumi, Y. Narita, Y. Yonamine, A. C. Weisman, Y. Nishimura, N. Oku, Y. Miura, K. J. Shea, A polymer nanoparticle with engineered affinity for a vascular endothelial growth factor (VEGF165), Nat. Chem., 10.1038/nchem.2749, 2017.03.
29.	M. Yue, K. Imai, C. Yamashita, Y. Miura, Y. Hoshino, Effects of Hydrophobic Modifications and Phase Transitions of Polyvinylamine Hydrogel Films on Reversible CO2 Capture Behavior: Comparison between Copolymer Films and Blend Films for Temperature‐Responsive CO2 Absorption, Macromol. Chem. and Phys., 10.1002/macp.201600570, 218, 1600570, 2017.02.
30.	Yu Hoshino, Takaaki Miyoshi, Masahiko Nakamoto, Yoshiko Miura, Wide-range p K a tuning of proton imprinted nanoparticles for reversible protonation of target molecules via thermal stimuli, Journal of Materials Chemistry B, 10.1039/c7tb02107k, 5, 46, 9204-9210, 2017.01, [URL].
31.	Masahiko Nakamoto, Tadashi Nonaka, Yoshiko Miura, Kenneth J. Shea, Yu Hoshino*, Design of Synthetic Polymer Nanoparticles that Facilitate Resolubilization and Refolding of Aggregated Positively Charged Lysozyme, J. Am. Chem. Soc., 10.1021/jacs.5b12600, 138, 2016.02, [URL].
32.	Lee Haejoo, Yu Hoshino*, Yusuke Wada, Yuka Arata, Atsushi Maruyama, Yoshiko Miura, Minimization of synthetic polymer ligands for specific recognition and neutralization of a toxic peptide, J. Am. Chem. Soc., 10.1021/jacs.5b05259, 137, 10878-10881, 2015.09, [URL].
33.	Mengchen Yue, Yu Hoshino*, Yoshiko Miura, Design Rationale of Thermally Responsive Microgel Particle Films That Reversibly Absorb Large Amounts of CO2: Fine Tuning the pKa of Ammonium Ions in the Particles, Chem. Sci., 10.1039/C5SC01978H, ASAP, 2015.08, [URL].
34.	Keiichi Yoshimatsu, Hiroyuki Koide, Yu Hoshino, Kenneth J. Shea, Preparation of abiotic polymer nanoparticles for sequestration and neutralization of a target peptide toxin, Nature protocols, 10.1038/nprot.2015.032, 10, 595–604, 2015.04, [URL].
35.	Yu Hoshino*, Yuka Arata, Haejoo Lee, Yusuke Yonamine, Shih-Hui Lee, Aki Yamasaki, Ryousuke Tsuhara, Katsuhiko Yano, Kenneth J Shea, Yoshiko Miura, Preparation of nanogel-immobilized porous gel beads for affinity separation of proteins: fusion of nano and micro gel materials, Polymer Journal, 10.1038/pj.2014.101, 47, 220–225, 2015.01, [URL].
36.	Yusuke Wada, Haejoo Lee, Yu Hoshino*, Shunsuke Kotani, Kenneth J. Shea, Yoshiko Miura, Design of multi-functional linear polymers that capture and neutralize a toxic peptide: a comparison with cross-linked nanoparticles, Journal of Materials Chemistry B, 10.1039/C4TB01967A, 3, 1706-1711, 2015.01, [URL].
37.	Yoke-Ming Wong, Yu Hoshino*, Kumar Sudesh, Yoshiko Miura, Keiji Numata*, Optimization of poly (N-isopropylacrylamide) as an artificial amidase, Biomacromolecules, 10.1021/bm501671r, 16, 411–421, 2015.01, [URL].
38.	Adam Weisman, Yingyao Allie Chen, Yu Hoshino, Huiting Zhang, Kenneth J. Shea, Engineering Nanoparticle Antitoxins Utilizing Aromatic Interactions, Biomacromolecules, 10.1021/bm500666j, 15, 3290–3295, 2014.06, [URL].
39.	Yu Hoshino*, Ryohei C. Ohashi, Yoshiko Miura, Rational Design of Synthetic Nanoparticles with a Large Reversible Shift of Acid Dissociation Constants: Proton Imprinting in Stimuli Responsive Nanogel Particles, Advanced Mater, 10.1002/adma.201305957, 26, 2449–2606, 2014.03, [URL].
40.	K. Yoshimatsu, T. Yamazaki, Yu Hoshino, L. F. Epstein, L. P. Miranda, P. Tagari, J. M. Beierle, Y. Ynamine, K. J. Shea, Epitope Discovery for a Synthetic Polymer Nanoparticle: A New Strategy for Developing a Peptide Tag, J. Am. Chem. Soc., 10.1021/ja410817p, 136, 1194–1197, 2014.01, [URL].
41.	Mengchen Yue, Yu Hoshino*, Yukinori Ohshiro, Kazushi Imamura, Yoshiko Miura, Temperature-Responsive Microgel Films as Reversible Carbon Dioxide Absorbents in Wet Environment, Angew. Chem. Int. Ed., 10.1002/ange.201309758, 126, 2692–2695, 2014.01, [URL].
42.	Masahiko Nakamoto, Yu Hoshino*, Yoshiko Miura*, Effect of Physical Properties of Nanogel Particles on the Kinetic Constants of Multipoint Protein Recognition Process, Biomacromolecules, 10.1021/bm401536v, 15, 541–547, 2013.12, [URL].
43.	Yonamine, Yusuke, Yoshimatsu, Keiichi, Lee, Shih-Hui, Yu Hoshino, Okahata, Yoshio, Shea, Kenneth J, Polymer Nanoparticle-Protein Interface. Evaluation of the Contribution of Positively Charged Functional Groups to Protein Affinity, ACS APPLIED MATERIALS & INTERFACES, 10.1021/am302404q, 5, 2, 374-379, 2013.01.
44.	Y. Hoshino*, K. Imamura , M. Yue , G. Inoue , Y. Miura*, Reversible absorption of CO2 triggered by phase transition of amine-containing micro- and nano-gel particles, J. Am. Chem. Soc., 10.1021/ja3080192, 134, 18177-18180, 2012.10, [URL].
45.	Y. Hoshino*, M. Nakamoto, and Y. Miura*, Control of protein-binding kinetics on synthetic polymer nanoparticles by tuning flexibility and inducing conformation changes of polymer chains, J. Am. Chem. Soc., 10.1021/ja306053s, 134, 15209−15212, 2012.09, [URL].
46.	S.-H. Lee, Y. Hoshino, A. Randall, Z. Zeng, P. Baldi, R.-a. Doong and K. J. Shea, Engineered Synthetic Polymer Nanoparticles as IgG Affinity Ligands, J. Am. Chem. Soc., 10.1021/ja303612d, 134, 15765−15772, 2012.09, [URL].
47.	Y. Yonamine, Y. Hoshino, and K. J. Shea, An ELISA-mimic screen for synthetic polymer nanoparticles with high affinity to target proteins, Biomacromolecules, 10.1021/bm300986j, 13, 2952–2957, 2012.07, [URL].
48.	K. Yoshimatsu, B. K. Lesel, Y. Yonamine, J. M. Beierle, Y. Hoshino, and K. J. Shea, Temperature-Responsive “Catch and Release” of Proteins by using Multifunctional Polymer-Based Nanoparticles, Angew. Chem. Int. Ed., 10.1002/anie.201107797, 51, 2405–2408, 2012.03, [URL].
49.	Y. Hoshino*, H. Koide, K. Furuya, W. W. Haberaecker III, S. Lee, T. Kodama, H. Kanazawa, N. Oku, and K. J. Shea*, The Rational Design of a Synthetic Polymer Nanoparticles that Neutralizes a Toxic Peptide in Vivo, Proc. Natl. Acad. Sci. USA, 10.1073/pnas.1112828109, 109, 33-38, 2012.01, [URL].
50.	Y. Hoshino, and K. J. Shea*, Evolution of Plastic Antibodies, J. Mat. Chem., 2010.10, [URL].
51.	Y. Hoshino*, W. W. Haberaecker III, T. Kodama, Z. Zeng, Y. Okahata, and K. J. Shea*, Affinity Purification of Multifunctional Polymer Nanoparticles, J. Am. Chem. Soc., 10.1021/ja1058982, 132, 13648-13650, 2010.09, [URL].
52.	Y. Hoshino*, H. Koide, T. Urakami, H. Kanazawa, T. Kodama, N. Oku, and K. J. Shea*, Recognition, Neutralization, and Clearance of Target Peptides in the Bloodstream of Living Mice by Molecularly Imprinted Polymer Nanoparticles: A Plastic Antibody, J. Am. Chem. Soc., 10.1021/ja102148f, 132, 6644–6645, 2010.04, [URL].
53.	Z. Zeng, Y. Hoshino, A. Rodoriguez, H. Yoo, and K. J. Shea, Synthetic Polymer Nanoparticles with Antibody-Like Affinity for a Hydrophilic Peptide, ACS nano, 10.1021/nn901256s, 4, 199–204, 2009.12, [URL].
54.	Y. Hoshino*, T. Urakami, T. Kodama, H. Koide, N. Oku, Y. Okahata, and K. J. Shea*, Design of Synthetic Polymer Nanoparticles that Capture and Neutralize Toxic Peptide, Small, 10.1002/smll.200900186, 5, 1562–1568, 2009.03.
55.	Y. Hoshino, T. Kodama, Y. Okahata, and K. J. Shea, Peptide Imprinted Polymer nanoparticles “Plastic Antibodies”, J. Am. Chem. Soc., 10.1021/ja8062875, 130, 15242-15243, 2008.10, [URL].
56.	Y. Hoshino, T. Kawasaki, and Y. Okahata, Effect of Ultrasound on DNA Polymerase Reactions: Monitoring on a 27-MHz Quartz Crystal Microbalance, Biomacromolecules, 10.1021/bm050738e, 7, 682–685, 2006.02, [URL].
57.	Y. Hoshino, S. Tajima, H. Nakayama, and Y. Okahata, A RNA-aligned Film Prepared from a RNA-Lipid Complex, Macromol. Rapid Commun., 10.1002/1521-3927(20020301)23:4, 23, 253-255, 2002.03, [URL].

主要総説, 論評, 解説, 書評, 報告書等

主要学会発表等

1.	Yu Hoshino1, Preparation of Defectless Hydrogel Nanomembranes for CO2 Separation by Microgel Particles, 2019 MRS SPRING MEETING ＆ EXHIBIT, 2019.04.
2.	郭本帥、星野友、山田鉄兵、三浦佳子, Thermo-Electrochemical Cell Development by Using Temperature Responsive Nanogel, 第67回高分子学会年次大会, 2018.05.
3.	本田竜太朗、行部智洋、島原秀登、三浦佳子、星野友, 炭酸脱水酵素固定化に向けたゲル粒子の調整と評価, 第67回高分子学会年次大会, 2018.05.
4.	星野友, 燃焼後排ガスからのCO2分離のためのゲル粒子塗布膜の開発, 日本膜学会第４０年会 人工膜シンポジウム１「社会実装を目指すCO2分離を主としたガス分離膜の研究開発最前線, 2018.05.
5.	片渕航汰、本田竜太郎、行部智洋、山下知恵、星野友、三浦佳子, 温度変化に応答して高速かつ低エネルギーでCO2を可逆吸収するナノゲル担持体の開発, 化学工学会第83年会, 2018.03.
6.	Y. Hoshino, Tuning pKa of Brønsted Acids in Temperature-Responsive Hydrogel Particles by Proton- and Ion-Imprinting Strategy, ACS 255rd National Meeting 2018, 2018.03.
7.	Shohei Taniguchi, Sho Katakami, Yusuke Yonamine, Yu Hoshino, Yoshiko Miura, Effects of the Number of Functional Groups of Discrete Oligomer Ligands Affinity to Target Peptide, 2017 Kyushu-Seibu/Pusan-Gyeongnam Joint Symposium on High Polymers (18th) and Fibers (16th), 2017.12.
8.	Ryuitaro Honda, Tomohiro Gyobu, Hideto Shimahara [JAIST], Yoshiko Miura, Yu Hoshino, Effect of Composition of Gel Particles on the Immobilization of Carbonic Anhydrase, 2017 Kyushu-Seibu/Pusan-Gyeongnam Joint Symposium on High Polymers (18th) and Fibers (16th), 2017.12.
9.	Mitsunori Moribe, Naoki Gondo, Masahiko Nakamoto, Yu Hoshino, Yoshiko Miura, Provement of Reversible Salt Absorption Efficiency of Temperature Responsive Gel Particle Composite Membrane, 2017 Kyushu-Seibu/Pusan-Gyeongnam Joint Symposium on High Polymers (18th) and Fibers (16th), 2017.12.
10.	谷口昇平、片上将、与那嶺雄介、星野友、三浦佳子, 重合度が完全に均一なプラスチックアプタマーの開発, 高分子学会九州支部特別講演会, 2017.11.
11.	星野　友, タンパク質を模倣したナノゲルの機能設計, ゲルワークショップ　イン　松山, 2017.09.
12.	Y. Hoshino, T. Miyoshi, T. Jibiki, Y. Miura, Tuning pKa of Brønsted Acids in Stimuli Responsive Nanogel Particles by Proton- and Ion-Imprinting Strategy for Reversible Capture of Target Molecules, Affinity 2017, 2017.06, Synthetic materials that alter their binding affinity to target molecules in response to　external stimuli have gained considerable attention as substitutes for protein based　ligands. Recently, we revealed that pNIPAm-based NPs that show large and　reversible pKa shifts can be prepared by the “proton imprinting” and　“microenvironment imprinting” strategy. The pKa variation range of　carboxylic acids in the NPs can further be tuned by designing structure of monomers　containing Brønsted acids and tuning cross-linking density and size of NPs. The pKa　variation range can be lowered/raised to be 4-9 by stabilizing/destabilizing carboxylate　anions by modifying the acids with electron withdrawing/donating group. The pKa of　acids can also be lowered dramatically by imprinting cationic functional group such as　guanidium group around the carboxylate anions. Our results provide a guide for designing stable and inexpensive materials for many　biological and chemical applications as temperature-dependent affinity media and pH　modifiers..
13.	Yu Hoshino, Development of Protein-Mimic Nanoparticles for Effective CO2 Separation, 23rd iCeMS International Symposium, 2017.05.
14.	谷口昇平、片上将、星野友、三浦佳子, 毒性ペプチドと相互作用する均一オリゴマーの作製と評価, 第66回高分子学会年次大会, 2017.05.
15.	星野友、郭本帥、高帆、山田鉄兵、君塚信夫、三浦佳子, 低温排熱の高効率回収を実現するゲル相転移駆動型温度差電池の開発, 第66回高分子学会年次大会, 2017.05.
16.	Y. Hoshino, T. Gyobu, R. Honda, K. Imamura, C. Yamashita, T. Watanabe, I. Taniguchi, Y. Miura, Development of Nanogel Membranes for CO2 Separation, ACS 253rd National Meeting 2017, 2017.04.
17.	星野　友, タンパク質を模倣したナノゲル粒子のpKa制御と機能開発, 日本化学会第97 春季年会特別企画講演生命化学が先導する分子機能創成の最先端：生体機能・生体分子を超えるためのアプローチ, 2017.03.
18.	Yu Hoshino, Toshiki Jibiki, Takaaki Miyoshi, Masaaki Nakamoto Yoshiko Miura, Tuning pKa Value of Bronsted Acids in Hydrogel Nanoparticles by Ion Imprinting Strategy, Gelsympo 2017, 2017.03.
19.	Yu Hoshino, Design of Synthetic Polymer Nanoparticles that Function as Molecular Chaperones, Asian International Symposium-Natural Products Chemistry, Chemical Biology/Biofunctional Chemistry and Biotechnology, 2017.03.
20.	星野 友, 大橋 良平, 三浦 佳子, Development of Enzyme-Mimic Proton Transfer Systems, IUMRS-International Conference on Electronic Materials (IUMRS-ICEM 2014), 2014.08.
21.	星野 友, 大橋 良平, 三浦 佳子, Preparation of Temperature Responsive Nanogels with Carboxylic Acids which Undergo Large and Reversible pKa Shift, IUMRS-International Conference on Electronic Materials (IUMRS-ICEM 2014), 2014.08.
22.	星野 友, 大橋　良平, Yue Mengchen, 今井　健太, 権藤　直樹, Yoshiko Miura, 大きなpKa変化を示すナノゲル粒子の合成とその応用, 第24回バイオ・高分子シンポジウム, 2014.07.
23.	星野 友, 大橋良平, 三浦 佳子, Preparation of Proton Imprinted Nanoparticles with Switchable pKa Values: Toward Plastic Enzymes, MRS Fall Meeting,2013, 2013.12.
24.	Yu Hoshino, Kazushi Imamura, Mengchen Yue, Yoshiko Miura, Reversible absorption of CO2 by aqueous solution of amine-containing poly-N-isopropylacrylamide particles, The 244th ACS National Meeting , 2013.04.
25.	Ryohei Ohashi, Yu Hoshino, Yoshiko Miura, Reversible absorption of protons by temperature-responsive gel-particles, The 244th ACS National Meeting , 2013.04.
26.	Yu Hoshino, Mengchen Yue, Yoshiko Miura, Hydrogel films consisting of temperature-responsive nanogels as an absorbent to capture CO2 reversibly, The 244th ACS National Meeting , 2013.04.
27.	LEE HAEJOO, Yusuke Wada, Yu Hoshino, Yoshiko Miura, Preparation and characterization synthetic polymer ligands that recognize target peptides with multipoint interaction, The 244th ACS National Meeting , 2013.04.
28.	LEE HAEJOO, Yusuke Wada, Yu Hoshino, Yoshiko Miura, Minimization of Polymer Ligands that Interact with Targeted Peptide, Soft-interfaces Mini-symposium 2013-Physical Chemistry and Characterization of Soft-interfaces-(SIMS2013) , 2013.03.
29.	Mengchen Yue, Yu Hoshino, Yoshiko Miura, Study on reversible CO2 absorption by thermo-responsive hydrogel films, Soft-interfaces Mini-symposium 2013-Physical Chemistry and Characterization of Soft-interfaces-(SIMS2013) , 2013.03.
30.	星野 友, プロトンポンプを模倣した熱駆動イオン輸送システムの開発, 第2回　次世代の物質科学・ナノサイエンスを探る　研究会, 2013.01.
31.	Yu Hoshino, Masahiko Nakamoto, Yoshiko Miura, Influence of polymer density of plastic antibodies on target binding kinetics, The 243rd ACS National Meeting , 2012.03.
32.	S.-H. Lee, Y. Hoshino, R.-a. Doong and K. J. Shea, Development of polymer nanoparticles that capture antibodies: “synthetic protein A”, ACS National Meeting Spring 2011, 3/2011, 2011.03.
33.	K. Yoshimatsu, B. Lesel, Y. Hoshino, and K. J. Shea, Interactions between designed synthetic polymer nanoparticles and a toxic peptide: toward understanding of factors behind the high affinity, ACS National Meeting Spring 2011, Anaheim, 3/2011, 2011.03.
34.	Y. Yonamine, Y. Hoshino, T. Yokoyama, K. Shimizu, N. Oku, and K. J. Shea, Synthetic polymer nanoparticles that capture the antigen protein of Japanese cedar pollen allergy, ACS National Meeting Spring 2011, 2011.03.
35.	M. Wada, Y. Miyazawa, Y. Hoshino, and Y. Miura, Specific biological ability of trehalose and multivalent trehalose on Aβ aggregation, ACS National Meeting Spring 2011, 2011.03.
36.	Y. Hoshino, H. Koide, D. Oyama, Y. Yonamine, S.-H. Lee, N. Oku, K. J. Shea, Design of polymer nanoparticles that are capable of neutralizing toxicity of fetal proteins, ACS National Meeting Spring 2011, 2011.03.
37.	Z. Zeng, Y. Hoshino, R. Blom, C. Nilsson, S. Nilsson and K. J. Shea, Epitope imprinting: synthetic polymer nanoparticles that recognize peptide and proteins, MIP 2010, 2010.08.
38.	Y. Hoshino, T. Kodama, Y. Okahata, and K. J. Shea, Affinity separation of stimuli responsive peptide-receptor nanoparticles: Towards a monoclonal “plastic” antibody, ACS National Meeting Spring 2010, 2010.03.
39.	Y. Hoshino, H. Koide, T. Urakami, H. Kanazawa, T. Kodama, N. Oku, and K. J. Shea, Recognition and neutralization of a toxic peptide in vivo by polymer nanoparticles, ACS National Meeting Spring 2010, 2010.03.
40.	Y. Hoshino, H. Koide, T. Kodama, T. Urakami, N. Oku, Y. Okahata, and K. J. Shea, Design of Polymer Nanoparticles to Capture and Neutralize the Toxic Peptide Melittin, ACS National Meeting Fall 2009, 2009.08.
41.	Y. Hoshino, T. Urakami, T. Kodama, H. Koide, N. Oku, Y. Okahata, and K. J. Shea, Preparation of High Affinity Plastic Antibodies by Molecular Imprinting and Affinity Purification -Preparation of Plastic Polyclonal Antibodies for Melittin, International Session of the 58th SPSJ Annual Meeting, 2009.05.
42.	Y. Hoshino, T. Urakami, T. Kodama, H. Koide, N. Oku, Y. Okahata, and K. J. Shea, Design of Polymer Nanoparticles that Capture Hemolytic Peptides by Optimizing Functional Monomers - Preparation of Plastic Antisera for Melittin, International Session of the 58th SPSJ Annual Meeting, 2009.05.
43.	Y. Hoshino, T. Kawasaki, and Y. Okahata, Analysis of Weak Ultrasound Effect on DNA Polymerase Activity Useing a Quartz Crystal Microbalance (QCM), Pacifichem2005, 2005.12.
44.	Y. Hoshino, T. Kawasaki, and Y. Okahata, Control of Lysozyme Activity by Weak Ultrasound Irradiation, First International Symposium on Biomolecular Chemistry (ISBC2003), 2003.12.
45.	Y. Hoshino, S. Tajima, H. Nakayama, and Y. Okahata, Preparation of a RNA-Lipid Complex Film and Its Physical Properties, The 28th Symposium on Nucleic Acids Chemistry, 2001.11.

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