九州大学 研究者情報
論文一覧
一杉 岳(ひとすぎ たかし) データ更新日:2022.04.04

講師 /  歯学研究院 歯学部門 口腔顎顔面病態学講座歯科麻酔学分野


原著論文
1. Rumi Iwai , Takunori Shimazaki, Yoshifumi Kawakubo, Kei Fukami, Shingo Ata, Takeshi Yokoyama, Takashi Hitosugi, Aki Otsuka, Hiroyuki Hayashi, Masanobu Tsurumoto, Reiko Yokoyama, Tetsuya Yoshida, Shinya Hirono, Daisuke Anzai, Quantification and Visualization of Reliable Hemodynamics Evaluation Based on Non-Contact Arteriovenous Fistula Measurement, Sensors, https://doi.org/10.3390/s22072745 , 22, 274, 2022.04.
2. Uno Imaizumi, Takashi Hitosugi*, Toshikazu Kobayashi, Kenichi Hirano, Takuji Asano, Yoshihiko Kinoshita, Reiko Yokoyama, Masanori Tsukamoto, Takeshi Yokoyama , Influence of exogenous adrenaline on insulin sensitivity under general anesthesia in canine model: a preliminary study, Human Cell, in press, 2022.03.
3. Masanori Tsukamoto, Shiori Taura, Takashi Hitosugi, Takeshi Yokoyama, A Case of Laryngeal Granulomas After Oral and Maxillofacial Surgery With Prolonged Intubation, Anesth Prog, 10.2344/anpr-68-01-03, 68(2):94-97, 2021.07.
4. Takashi Hitosugi, Izumi Kameyama, Shiori Taura, Masanori Tsukamoto, Takeshi Yokoyama, Postoperative Respiratory Impairment and Prevention due to Secretions from Patients with Cleft Lip and Palate, Masui, 2021.11.
5. Hitosugi T., Tsukamoto M., Yokoyama T., Anesthetic Management of Paget’s Disease Patient with Mandibular Hyperplasia and Severe Trisums, Masui, 69, 2020.11.
6. Hitosugi T*, Mitsuyasu T, Yokoyama T, Cleft-lip-plate Patient with Tracheobronchomalacia: A case report and review of the literature in Japan (In Press), Journal of Plastic, Reconstructive & Anesthetic Surgery, 26, 60-68, 2020.11.
7. Shimazaki Takunori, Kawakubo Yoshifumi, Hara Shinsuke, Hitosugi Takashi, Yokoyama Takeshi, Miki Yoichiro, Blood Leakage Determination Using the Chromaticity of a Color Sensor, Advanced Biomedical Engineering, 10.14326/abe.8.177, 8, 0, 177-184, 2019.12,

Percutaneous extracorporeal circulation therapies such as apheresis and hemodialysis are commonly used in intensive care units, hemodialysis centers, and clinically settings. In these treatments, there is always a possibility of continuous bleeding from the puncture site. Since the blood flow in these therapies is high, a hemorrhagic shock may be caused by severe blood loss, and - in the worst case - this may even lead to the patient's death. Therefore, it is important to continuously monitor blood leakage during the treatment. Typical procedures include the electrode method and the blood absorbance method, but their function may be affected by leakage of colored chemicals used, or by sweat or light. In this study, we developed a blood leakage determination module based on the chromaticity of a color sensor. Since the method is specifically sensitive to the red color, it can detect blood leakage. We performed experiments to verify the effectiveness of the proposed method and compared this new procedure with the existing ones, and we confirmed that the proposed method correctly detected blood leakage. Moreover, we investigated the blood detection capability of our new procedure and found that it could be applied to detect hematocrit levels within the range of 2% to 64%. We developed a multicolor sensor module and established a blood leakage detection method to meet the conditions that we had set as our goal. Our study confirmed that the proposed method did not cause malfunction due to leakage of chemical or presence of obstacle in the light path, while the traditional methods did. We also evaluated its performance and found that our method was able to detect blood leakage within the hematocrit range of 2% to 64%.

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8. Hitosugi T.*, Awata N., Miki Y., Tsukamoto M., Yokoyama T., More Effective Way for Stabilization of a Dental Chair when CPR is Required., Anesth Prog, 2021.08.
9. Tsukamoto M., Taura S., Yamanaka H., Hitosugi T., Yokoyama T., Prediction of appropriate formula for nasotracheal tube size in developmental disability children., Clin Oral Invest, 10.1007/s00784-020-03517-9., 2020.08.
10. Tsukamoto M., Yamanaka H., Hitosugi T., Yokoyama T., Endotracheal Tube Migration Associated With Extension During Tracheotomy., Anesth Prog, 67, 3-8, 2020.08.
11. Ifuku T., Hitosugi T.*, Kawakubo Y, Tanaka T., Doi K., Yokoyama T., Effective Method Using a Stool in Cardiopulmonary Resuscitation (CPR) on Dialysis Chair., Emergency Medicine International, 10.1155/2020/5691607, 2020.07.
12. Hitoshi Yamanaka, Masanori Tsukamoto, Takashi Hitosugi, Takeshi Yokoyama, Mask Induction for an Intellectually Disabled Patient With Congenital Infiltrating Lipomatosis of the Face, Anesthesia Progress, 10.2344/anpr-67-01-01, 67, 2, 98-102, 2020.07.
13. Tsukamoto M., Hitosugi T. *, Yokoyama T., Comparison of recovery in pediatric patients: a retrospective study., Clin Oral Investig, 23, 3653-3656, 2020.06.
14. Hitosugi T., Tsukamoto M., Yokoyama T., Anesthetic Management of Paget’s Disease Patient with Mandibular Hyperplasia and Severe Trisums., Masui, 69, 2020.06.
15. Hayashi K., Hitosugi T.*, Kawakubo Y., Kitamoto N., Yokoyama T., Influence of Measurement Principle on Total Hemoglobin Value, BMC Anesthesiol, 10.1186/s12871-020-00991-2, 20, 1, 81, 2020.04.
16. 一杉 岳, 太田 百合子, 坂井 洵子, 田浦 志央吏, 衛藤 希, 守永 紗織, 塚本 真規, 横山 武志, 肥大型心筋症とてんかんを伴ったヌーナン症候群患者の全身麻酔経験., 日本歯科麻酔学会雑誌, 48, 60-62, 2020.04.
17. 一杉 岳, 細川 瑠美子, 塚本 真規, 横山 武志, 頸部手術の閉創操作により脳血流低下を認めた内頸動脈狭窄症患者 脳内酸素飽和度モニタリングの頸部手術における有用性, 麻酔, 69, 2, 155-160, 2020.02.
18. Kitamoto N., Hitosugi T.*, Kawakubo Y., Hayashi K., Yokoyama T, The Measurement of Blood Pressure by the Linear Method Compared to the Deflation Methods Differently Modifies the Pulse Oximeter Alarm Frequency, Blood Press Monit, 10.1097/MBP.0000000000000408, 25, 1, 13-17, 2020.02.
19. 一杉 岳, 塚本 真規, 門脇 さゆり, 山中 仁, 横山 武志, 重度心奇形を伴う多脾症候群患児の全身麻酔下歯科治療経験., 麻酔, 69, 632-637, 2020.02.
20. 一杉 岳, 塚本 真規, 横山 武志, 高度開口障害を伴ったペリツェウス・メルツバッハー病患者の麻酔経験, 麻酔, 69, 1, 92-96, 2020.01.
21. 廣川 惇, 塚本 真規, 一杉 岳, 永野 沙紀, 横山 武志, 1番染色体異常の小児患者に対する口蓋形成術の麻酔経験, 麻酔, 68, 12, 1335-1339, 2019.12.
22. Takashi Hitosugi, Masanori Tsukamoto, Takeshi Yokoyama, Pneumonia Due to Aspiration of Povidine Iodine After Preoperative Disinfection of the Oral Cavity, Oral Maxillofac Surg, 23, 4, 507-511, 2019.11.
23. 田浦 志央吏山中 仁, 塚本 真規, 一杉 岳, 横山 武志, 知的障害を有する先天性浸潤性脂肪腫症患児の全身麻酔経験, 日本歯科麻酔学会雑誌, 47, 254, 2019.09.
24. Awata N., Hitosugi T.*, Miki Y., Tsukamoto M., Kawakubo Y., Yokoyama T., Usefulness of a stool to stabilize dental chairs for cardiopulmonary resuscitation (CPR), BMC Emergency Medicine, 10.1186/s12873-019-0258-x, 19, 2019.08.
25. Tsukamoto M., Taura S., Yamanaka H., Hitosugi T., Kawakubo Y., Yokoyama T., Age-related effects of three inhalational anesthetics at one minimum alveolar concentration on electroencephalogram waveform., Clin Exp Res, 10.1007/s40520-019-01378-1., 2019.08.
26. 坂本 英治, 大島 優, 塚本 真規, 一杉 岳, 横山 武志, 口腔顔面痛患者におけるPDASの評価についての検討, 日本歯科心身医学会雑誌, 33, 2, 106-107, 2018.12.
27. Hitoshi Yamanaka, Masanori Tsukamoto, Takashi Hitosugi, Takeshi Yokoyama, Changes in nasotracheal tube depth in response to head and neck movement in children, Acta Anaesthesiologica Scandinavica, 10.1111/aas.13207, 62, 10, 1383-1388, 2018.11, [URL], Background: A tracheal tube is often inserted via the nasal cavity for dental surgery. The position of the tube tip is important, given that the head position sometimes changes during surgery. Head movement induces changes in the length of the trachea (t-length) and/or the distance between the nare and the vocal cords (n-v-distance). In this study, we investigated the changes in t-length and n-v-distance in children undergoing nasotracheal intubation. Methods: Eighty patients aged 2-8 year undergoing dental surgery were enrolled. After nasotracheal intubation with an uncuffed nasotracheal tube (4.5-6.0 mm), the tube was fixed at the patient's nares. The distance between the tube tip and the first carina was measured using a fibrescope with the angle between the Frankfort plane and horizontal plane set at 110°. The location of the tube in relation to the vocal cords was then checked. These measurements were repeated at angles of 80° (flexion) and 130° (extension). The t-length and n-v-distance were then calculated using these measurements. Results: On flexion, the t-length shortened significantly from 87.5 ± 10.4 mm to 82.9 ± 10.7 mm (P = 0.017) and the n-v-distance decreased from 128.1 ± 10.7 mm to 125.6 ± 10.4 mm (P = 0.294). On extension, the t-length increased significantly from 87.5 ± 10.4 mm to 92.7 ± 10.1 mm (P = 0.007) and the n-v-distance increased from 128.1 ± 10.7 mm to 129.4 ± 10.7 mm (P = 0.729). The change in t-length was significantly greater than that in the n-v-distance. Conclusion: A change in the position of the tracheal tube tip in the trachea depends mainly on changes in t-length during paediatric dental surgery..
28. Masanori Tsukamoto, Takashi Hitosugi, Hitoshi Yamanaka, Takeshi Yokoyama, Postoperative Alopecia Following Oral Surgery, Journal of Oral and Maxillofacial Surgery, 10.1016/j.joms.2018.07.011, 76, 11, 2318.e1-2318.e3, 2018.11, [URL], Postoperative alopecia is an uncommon complication and its outcome is an esthetically drastic change. Although its mechanism has not been clearly reported, risk factors might be positioning and prolonged operative time during oral surgeries. In addition, perioperative stressful conditions might influence the biological clock of the hair cycle. This report presents 2 cases of postoperative alopecia after oral surgery. Prevention of alopecia with type of headrest, change in head positioning, and avoidance of continuous compression is important..
29. 坂本 英治, 大島 優, 塚本 真規, 一杉 岳, 横山 武志, 咀嚼筋の筋筋膜痛患者の舌圧と咬筋の動きの関連性についての検討, Journal of Musculoskeletal Pain Research , 10, 3, 97, 2018.11.
30. Masanori Tsukamoto, Takashi Hitosugi, Takeshi Yokoyama, Awake fiberoptic nasotracheal intubation for patients with difficult airway, J Dent Anesth Pain Med., 10.17245/jdapm.2018.18.5.301, 18, 5, 301-304, 2018.10.
31. Masanori Tsukamoto, Takashi Hitosugi, Hitoshi Yamanaka, Takeshi Yokoyama, Bifid epiglottis, high-arched palate, and mental disorder in a patient with Pallister–Hall syndrome, Indian Journal of Anaesthesia, 10.4103/ija.IJA_317_18, 62, 10, 825-827, 2018.10, [URL].
32. 大島 優, 坂本 英治, 衛藤 希, 坂井 洵子, 塚本 真規, 一杉 岳, 横山 武志, Pain Visionによる口腔顔面痛評価法の検討, 日本歯科麻酔学会雑誌, 46, 147, 2018.09.
33. Hitosugi T.*, Saito T., Oi Y., The Degree of Vascular Leak of Hydroxyethyl Starch in Severe Hemorrhagic Shock in Rats, Clinics in Surgery, http://www.clinicsinsurgery.com/full-text/cis-v3-id2021.php, 2018.07.
34. Takashi Hitosugi, Masahiro Tsukamoto, Jun Hirokawa, Takeshi Yokoyama, In dental office, supine abdominal thrust is recommended as an effective relief for asphyxia due to aspiration, American Journal of Emergency Medicine, 10.1016/j.ajem.2017.10.061, 36, 7, 2018.07.
35. 廣川 惇, 塚本 真規, 一杉 岳, 横山 武志, Dravet症候群患者の歯科治療における静脈内鎮静法および全身麻酔管理経験, 日本歯科麻酔学会雑誌, 46, 3, 136-138, 2018.07.
36. 坂本 英治, 大島 優, 塚本 真規, 一杉 岳, 横山 武志, 口腔顔面痛患者におけるPDASの評価についての検討, 本顎関節学会雑誌, 30, 113, 2018.07.
37. Masanori Tsukamoto, Jun Hirokawa, Takashi Hitosugi, Takeshi Yokoyama, Airway management for a pediatric patient with a tracheal bronchus, Anesthesia Progress, 10.2344/anpr-64-04-02, 65, 1, 50-51, 2018.03, [URL], Tracheal bronchus is an ectopic bronchus almost arising from the right side of the tracheal wall above the carina. The incidence of a tracheal bronchus is reported as 0.1 to 3%. We experienced a patient with tracheal bronchus that was incidentally found at induction of anesthesia. Endotracheal intubation in a patient with tracheal bronchus might cause obstruction of the tracheal bronchus, although in this case, ventilation was not impaired..
38. Shigeki Joseph Luke Fujiwara, Keiichi Tachihara, Satoshi Mori, Kentaro Ouchi, Shoko Itakura, Michiko Yasuda, Takashi Hitosugi, Uno Imaizumi, Yoichiro Miki, Izumi Toyoguchi, Kazu ichi Yoshida, Takeshi Yokoyama, Influence of the marvelous™ three-way stopcock on the natural frequency and damping coefficient in blood pressure transducer kits, Journal of Clinical Monitoring and Computing, 10.1007/s10877-017-9979-0, 32, 1, 63-72, 2018.02, [URL], Two types of Planecta™ ports are commonly used as sampling ports in blood pressure transducer kits: a flat-type port (FTP) and a port with a three-way stopcock (PTS). Recently, a new type of three-way stopcock (Marvelous™) has been released as a Planecta™ counterpart, but its effects on the frequency characteristics and reliability of blood pressure monitoring have not been investigated. We assessed the influence of the Marvelous™ stopcock on the frequency characteristics of the pressure transducer kit. The basic pressure transducer kit, DT4812J, was modified by replacing one or two of the original three-way stopcocks with Marvelous™ stopcocks. The frequency characteristics (i.e., natural frequency and damping coefficient) of each kit were determined using wave parameter analysis software, and subsequently evaluated on a Gardner chart. Replacement of the original blood pressure transducer kit stopcocks with Marvelous™ stopcocks decreased the natural frequency (48.3 Hz) to 46.3 Hz or 44.8 Hz, respectively; the damping coefficient was not significantly changed. Plotting the data on a Gardner chart revealed that the changes fell within the adequate dynamic response region, indicating they were within the allowable range. Insertion of Marvelous™ stopcocks slightly affects the natural frequency of the pressure transducer kit, similar to inserting a PTS. The results indicate that the Marvelous™ stopcock is useful for accurate monitoring of arterial blood pressure, and may be recommended when insertion of two or more closed-loop blood sampling systems is necessary..
39. Masanori Tsukamoto, Takashi Hitosugi, Takeshi Yokoyama, Influence of fasting duration on body fluid and hemodynamics, Anesthesia Progress, 10.2344/anpr-65-01-01, 64, 4, 226-229, 2017.12, [URL], Fasting before general anesthesia aims to reduce the volume and acidity of stomach contents, which reduces the risk of regurgitation and aspiration. Prolonged fasting for many hours prior to surgery could lead to unstable hemodynamics, however. Therefore, preoperative oral intake of clear fluids 2 hours prior to surgery is recommended to decrease dehydration without an increase in aspiration risk. In this study, we investigated the body fluid composition and hemodynamics of patients undergoing general anesthesia as the first case of the day versus the second subsequent case. We retrospectively reviewed the general anesthesia records of patients over 20 years old who underwent oral maxillofacial surgery. We investigated patient demographics, preoperative fasting time, anesthetic time, urine output, infusion volume, and opioid and vasopressor use. With respect to body fluid and hemodynamics, we extracted the data from the induction of anesthesia through 2 hours of anesthesia time. Thirty patients were suitable for this study. Patients were divided into 2 groups: patients who underwent surgery as the first case of the day (AM group: n=15) and patients who underwent surgery as the second case (PM group: n = 15). There were no significant differences between the 2 groups in patient demographics. In the PM group, fasting time for a light meal (832 minutes) was significantly longer than for the AM group (685 minutes), p =.005. In the PM group, fasting time for clear fluids (216 minutes) was also significantly longer than for the AM group (194 minutes), p =.005. Body fluid composition was not significantly different between the 2 groups. In addition, cardiac parameters intraoperatively were stable. In the PM group, vasopressors were used in 4 patients at the induction of anesthesia (p =.01). There were not statistically significant changes in cardiac function or body fluid composition between patients treated as the first case of the day vs patients who underwent surgery with general anesthesia as the second case of the day..
40. Masanori Tsukamoto, Takashi Hitosugi, Kanako Esaki, Takeshi Yokoyama, The anesthetic management for a patient with trisomy 13, Anesthesia Progress, 10.2344/anpr-64-02-09, 64, 3, 162-164, 2017.09, [URL], Trisomy 13 is a chromosomal disorder that occurs in complete or partial mosaic forms. It is characterized by central apnea, mental retardation, seizure and congenital heart disease. The survival of the patients with trisomy 13 is the majority dying before one month. Trisomy 13 is the worst life prognosis among all trisomy syndromes. It is reported the cause of death is central apnea. Special needs patients with mental retardation are recognized to have poorer oral health condition. Oral health related quality of life reflects daily activity and well-being. Dental treatment under general anesthesia is sometimes an option for such patients. This patient had received ventricular septal defect closure surgery at 2-year-old. In addition, he had mental retardation and seizure. Dental treatment had been completed without any cerebral and cardiovascular events under non-invasive monitoring with not only cardiac electric velocimetry, but also epileptogenic activity. In addition, postoperative respiratory condition was maintained stable in room air..
41. Masanori Tsukamoto, Sayuri Koyama, Kanako Esaki, Takashi Hitosugi, Takeshi Yokoyama, Low-dose carperitide (α-human A-type natriuretic peptide) alleviates hemoglobin concentration decrease during prolonged oral surgery a randomized controlled study, Journal of Anesthesia, 10.1007/s00540-017-2309-3, 31, 3, 325-329, 2017.06, [URL], Purpose: Surgical injury stimulates the renin–angiotensin–aldosterone system (RAAS) and causes antidiuresis, leading to postoperative oliguria. Carperitide (α-human A-type natriuretic peptide) is a cardiac peptide hormone secreted from the atrium. This peptide hormone enhances diuresis by suppressing the RAAS. In our experience, carperitide alleviates decreased hemoglobin (Hb) concentration during elective surgery. In the current study, we investigated the relationship between low-dose carperitide (0.01 µg/kg/min) and Hb concentration during oral surgery. Methods: Patients (ASA-PS: I–II, 40–80 years old) undergoing oral maxillofacial surgery (duration of operation >8 h) were enrolled in this study. Patients were divided into two groups: the carperitide group received carperitide at 0.01 µg/kg/min and the control group received normal saline. Body fluid water [including total body water (TBW), extracellular water (ECW), and intracellular water (ICW)], urine volume, and chemical parameters such as Hb concentration, PaO2, and serum electrolytes were evaluated every 2 h. Results: In the carperitide group (n = 15), Hb decreased from 12.6 ± 1.1 to 10.8 ± 1.5 g/dl, while it decreased from 12.6 ± 1.4 to 9.5 ± 1.3 g/dl in the control group (n = 15) (p < 0.05). Urine volume (2557.3 ± 983.5 mL) in the carperitide group was significantly more than it was in the control group (1108.8 ± 586.4 mL; p < 0.001). There were no significant differences in clinical characteristics, body fluid water, PaO2, and serum electrolytes between the two groups. In addition, there were no perioperative clinical respiratory and hemodynamic complications in the groups. Conclusion: The Hb concentration in the group administered low-dose carperitide at 0.01 µg/kg/min remained higher than that in the control group during surgery. Administration of low-dose carperitide may therefore reduce the risk of blood transfusion during surgery..
42. 廣川 惇, 川久保 芳文, 塚本 真規, 一杉 岳, 横山 武志, 心電図フィルターによる全身麻酔中の波形変化の検討, 臨床モニター, 28, 75, 2017.06.
43. Tsukamoto M., Hitosugi T., Yokoyama T., Flexible laryngeal mask airway management for dental treatment cases associated with difficult intubation., J Dent Anesth Pain Med., 17, 61-64, 2017.06.
44. 一杉 岳, 塚本 真規, 横山 武志, クリッペル・フェール症候群の小児に対する2度の全身麻酔経験, 麻酔, 66, 5, 554-557, 2017.05.
45. 塚本 真規, 一杉 岳, 横山 武志, CMOSビデオリノラリンゴスコープによる気道評価の有効性, 麻酔, 66, 5, 558-560, 2017.05.
46. Masanori Tsukamoto, Takashi Hitosugi, Kanako Esaki, Takeshi Yokoyama, The anesthetic management for a special needs patient with trisomy 18 accompanying untreated tetralogy of Fallot, Egyptian Journal of Anaesthesia, 10.1016/j.egja.2016.09.001, 33, 2, 213-215, 2017.04, [URL], Special needs patients with mental retardation are recognized to have poorer oral health condition. Oral health related quality of life reflects daily activity and well-being. Dental treatment under general anesthesia is often an option for such patients. Trisomy 18 is characterized by congenital heart disease, craniofacial abnormality and mental retardation. Congenital heart disease can be greater risk during anesthesia. In the case of trisomy 18 with untreated tetralogy of Fallot, especially right-to-left shunting and/or pulmonary artery stenosis may reduce pulmonary blood flow, and may develop life-threatening hypoxemia. We anesthetized a patient with trisomy 18 accompanying untreated tetralogy of Fallot for dental treatment. The hemodynamics including cardiac output has been monitored non-invasively using electrical velocimetry method. Its systemic vascular resistance and pulmonary vascular resistance were maintained appropriately, and dental treatments were successfully completed..
47. 塚本 真規, 一杉 岳, 横山 武志, 類洞交通を認める純型肺動脈閉鎖患者の口唇形成術の全身麻酔経験, 麻酔, 66, 4, 431-433, 2017.04.
48. 一杉 岳, 塚本 真規, 横山 武志, 無呼吸発作と貪気を伴う成人レット症候群患者の麻酔経験, 麻酔, 66, 2, 2017.02.
49. Masanori Tsukamoto, Takashi Hitosugi, Kanako Esaki, Takeshi Yokoyama, Anesthetic management of a patient with emanuel syndrome, Anesthesia Progress, 10.2344/16-00028.1, 63, 4, 201-203, 2016.12, [URL], Emanuel syndrome is associated with supernumerary chromosome, which consists of the extra genetic material from chromosome 11 and 22. The frequency of this syndrome has been reported as 1 in 110,000. It is a rare anomaly associated with multiple systemic malformations such as micrognathia and congenital heart disease. In addition, patients with Emanuel syndrome may have seizure disorders. We experienced anesthetic management of a patient with Emanuel syndrome who underwent palatoplasty. This patient had received tracheotomy due to micrognathia. In addition, he had atrial septal defect, mild pulmonary artery stenosis, and cleft palate. Palatoplasty was performed without any complication during anesthesia. Close attention was directed to cardiac function, seizure, and airway management..
50. Masanori Tsukamoto, Takashi Hitosugi, Takeshi Yokoyama, Discrepancy between electroencephalography and hemodynamics in a patient with Cockayne syndrome during general anesthesia, Journal of Clinical Anesthesia, 10.1016/j.jclinane.2016.09.022, 35, 424-426, 2016.12, [URL], Cockayne syndrome is a kind of progeria with autosomal chromosome recessiveness described first by Cockayne in 1936. Patients with this syndrome were characterized by retarded growth, cerebral atrophy, and mental retardation. We experienced an anesthetic management of a patient with Cockayne syndrome, who underwent dental treatment twice. The primary concern was discrepancy between electroencephalography and hemodynamics. The values of bispectral index showed a sharp fall to 1 digit and suppression ratio more than 40, while hemodynamics was stable during induction of anesthesia with sevoflurane 8%. We should pay attention to anesthetic depth in the central nervous system in patients with Cockayne syndrome. Titration of anesthetics should be performed by the information from electroencephalography..
51. Masanori Tsukamoto, Takashi Hitosugi, Kanako Esaki, Takeshi Yokoyama, Risk Factors for Postoperative Shivering After Oral and Maxillofacial Surgery, Journal of Oral and Maxillofacial Surgery, 10.1016/j.joms.2016.06.180, 74, 12, 2359-2362, 2016.12, [URL], Purpose Postoperative shivering is a frequent complication of anesthesia. However, there are few reports about postoperative shivering in oral and maxillofacial surgery. Postoperative shivering in patients after osteotomy was observed from April 2008 to September 2015. This retrospective study investigated the risk factors of postoperative shivering in oral and maxillofacial surgery. Patients and Methods Anesthesia records of patients who underwent an osteotomy of the maxilla or mandible were checked. A patient's background (gender, age, height, and weight), anesthesia time, operative time, fentanyl, remifentanil, fluid volume, urine volume, blood loss volume, agent for anesthetic maintenance, rectal temperature at the end of surgery, and type of surgery were recorded in addition to the occurrence of postoperative shivering. In the univariate analysis, the Fisher exact test and the χ2 test were used, and a multivariable analysis was performed using stepwise logistic regression to determine risk factors of postoperative shivering. Results In this study, 233 cases were investigated, and 24 patients (11.5%) had postoperative shivering. The occurrence of postoperative shivering was correlated with blood loss volume (shivering group, 633.9 ± 404.8 mL; nonshivering group, 367.0 ± 312.6 mL; P < .01) and core temperature at the end of surgery (shivering group, 37.2 ± 0.6°C; nonshivering group, 37.5 ± 0.5°C; P < .01). Two variables were associated with postoperative shivering. Rectal temperature at the end of surgery was the highest risk factor (odds ratio = 2.560277; 95% confidence interval, 1.236774-5.327362), and blood loss volume was the next highest risk factor (odds ratio = 0.997733; 95% confidence interval, 0.999-0998). Conclusion Clinicians should pay attention to postoperative shivering not only in patients with hypothermia but also in patients with substantial blood loss..
52. 坂本 英治, 石井 健太郎, 大島 優, 中嶋 康経, 江崎 加奈子, 塚本 真規, 一杉 岳, 横山 武志, 非歯原性歯痛の診断までにうけた治療歴と医療費についての検討, 日本口腔顔面痛学会雑誌, 9, 1, 1-9, 2016.12.
53. 一杉 岳, シリンジとシリンジポンプの互換性、プレフィルドシリンジについて, 日本臨床麻酔学会誌, 36, 6, 246, 2016.10.
54. 坂本 英治, 石井 健太郎, 大島 優, 加藤 遥, 江崎 加奈子, 細川 瑠美子, 塚本 真規, 一杉 岳, 細井 昌子, 横山 武志, 頭頸部筋筋膜痛症患者の診断までの治療歴の状況についての検討, Journal of Musculoskeletal Pain Research, 8, 3, 112, 2016.10.
55. Tsukamoto M., Hitosugi T., Esaki K., Yokoyama T., Body composition and hemodynamic changes in patients with special needs., J Dent Anesth Pain Med., 16, 193-197, 2016.10.
56. 一杉 岳, 塚本 真規, 林 啓介, 北本 憲永, 藤原 茂樹, 横山 武志, 各種シリンジ(50mL)およびシリンジポンプの機種間の互換性・経時的注入量誤差率の比較(第2報), 臨床麻酔, 40, 9, 1299-1305, 2016.09.
57. 坂本 英治, 石井 健太郎, 大島 優, 中嶋 康経, 江崎 加奈子, 塚本 真規, 一杉 岳, 横山 武志, 非歯原性歯痛の診断までにうけた治療歴と医療費についての検討., 日本口腔顔面痛学会雑誌, 1-9, 2016.09.
58. 一杉 岳, 「ヨーロッパ蘇生ガイドライン2015」における歯科治療中の心停止への対処, LiSA, 23, 8, 741-741, 2016.08.
59. 一杉 岳, 塚本 真規, 林 啓介, 北本 憲永, 藤原 茂樹, 横山 武志, 各種シリンジおよびシリンジポンプの機種間の互換性 各種シリンジとポンプの経時的注入量誤差率の比較, 臨床麻酔, 40, 7, 1053-1058, 2016.07.
60. Takashi Hitosugi, Masanori Tsukamoto, Shigeki Fujiwara, Takeshi Yokoyama, Perioperative management of a child with vocal adhesion leading to unexpected difficult airway, Japanese Journal of Anesthesiology, 65, 6, 590-593, 2016.06, We report a child with vocal cord adhesion encountered during induction of anesthesia A 4-month-old girl was scheduled for bilateral lip plasty. She was intubated for one week due to pneumonia at the age of 3 days. Hoarseness and stridor appeared just after extubation. Although laryngo-fiberoptic examination had been tried several times, otorhinologists could not find any abnormality. We once decided to postpone the operation because of severe stridor. However, laryngofiberoptic examination could not reveal any abnormality, and we rescheduled the operation. Tracheal intubation using laryngoscope was not possible due to vocal cord adhesion. Finally, 2.5 mm ID tracheal tube was intubated by using a fiberscope, and lip plasty was performed. The patient stayed in the ICU for 7 days after surgery. Tracheotomy was performed 3 weeks after the operation. We should pay attention to stridor in an infant before general anesthesia, since it suggests severe airway narrowing although laryngo-fiberoptic examination could not find any abnormalities..
61. 一杉 岳, 塚本 真規, 藤原 茂樹, 横山 武志, 喉頭内視鏡検査で声帯癒着が見逃されたため挿管および気道管理に苦慮した1症例, 麻酔, 65, 6, 590-593, 2016.06.
62. 一杉 岳, Williams症候群患児の全身麻酔下歯科治療経験, 日本歯科麻酔学会雑誌, 44, 2, 150-152, 2016.04.
63. 一杉 岳, 二次癌(舌癌)手術時に肺転移を見出せなかった慢性移植片対宿主病患者, 臨床麻酔, 40, 4, 593-597, 2016.04.
64. 一杉 岳, 林 啓介, 北本 憲永, 横山 武志, プレフィルドシリンジおよびシリンジポンプの機種間の互換性 各種シリンジとポンプの経時的注入量誤差率の比較, 臨床モニター, 27, 57, 2016.04.
65. 北本 憲永, 林 啓介, 川久保 芳文, 一杉 岳, 横山 武志, 非観血式血圧測定方法の違いによるパルスオキシメータアラーム発生頻度の比較, 臨床モニター, 27, 54, 2016.04.
66. 林 啓介, 村上 幸司, 上田 貴美子, 内海 美智子, 北本 憲永, 川久保 芳文, 一杉 岳, 横山 武志, カプセル内視鏡とテレメトリー式心電送信機との電磁干渉について, 臨床モニター, 27, 47, 2016.04.
67. Tsukamoto M., Hitosugi T., Esaki K., Yokoyama T., Risk Factors for Postoperative Shivering After Oral and Maxillofacial Surgery., J Oral Maxillofac Surg, 10.1016/j.joms.2016.06.180., 74, 2359-2362, 2016.04.
68. 一杉 岳, ダンディー・ウォーカー症候群に対し学童後期に静脈内鎮静と6回の繰り返し全身麻酔の経験, 麻酔, 65, 3, 304-307, 2016.03.
69. Takashi Hitosugi, Masanori Tsukamoto, Kentaro Ishii, Masanori Kadowaki, Shigeki Fujiwara, Takeshi Yokoyama, Anesthesia management of a patient with pulmonary atresia, intact ventricular septum, major aortopulmonary collateral artery and tetralogy of fallot, Japanese Journal of Anesthesiology, 65, 3, 291-295, 2016.03, The patient was a 6-year-old girl with pulmonary atresia, intact ventricular septum and major aortopulmonary collateral artery with tetralogy of Fallot Her Spo2 was around 60% under room air, and she could not walk long. She underwent dental treatment under general anesthesia. Invasive monitoring using pulmonary artery catheter should have been avoided, since the risk of monitoring greatly exceeds that of the treatment. The patient entered the operating room with her mother, and anesthesia was induced with intravenous midazolam, propofol and vecuronium. She was intubated orally first and impedance cardiography monitoring was started. FIO2 was maintained at 0.5-1.0. Increases in airway pressure and PaCo2 were appropriately avoided. Dental treatment is important for infants with cardiac disease not only to reduce their pain, but also to reduce the risk of infection. It often requires general anesthesia. We have to conduct it with less invasiveness and less stress..
70. Takashi Hitosugi, Masanori Tsukamoto, Shigeki Fujiwara, Takeshi Yokoyama, Intravenous sedation and repeated "the same day general anesthesia" for a school-age boy with dandy-walker syndrome and dentinogenesis, Japanese Journal of Anesthesiology, 65, 3, 304-307, 2016.03, Dandy-Walker syndrome (DWS) is characterized by perfect or partial defect of the cerebellum vermis and cystic dilatation of the posterior fossa communicating with the fourth ventricle. Common clinical signs are mental retardation, cerebellar ataxia, and those of increased intracranial pressure (ICP). Associated congenital anomalies are craniofacial, cardiac, renal, and skeletal abnormalities. We experienced a case of intravenous sedation and six times of "the same day" general anesthesia for a school-aged boy (10-13 years old) with DWS and hypodentinogenesis. The patient underwent an examination and dental treatments. We had to pay attention to airway management tracheal tube selection and control of ICP. In addition, we should prevent tooth injuries through mishaps during tracheal intubations, since all tooth-hypoplasia with fragile dental crowns was strongly suggested in this case. Detailed postoperative care is also required for general anesthesia afflicted with DWS..
71. 一杉 岳, 塚本 真規, 石井 健太郎, 門脇 正知, 藤原 茂樹, 横山 武志, 肺動脈閉鎖症、心室中隔欠損、主要大動脈肺動脈側副動脈を合併したファロー四徴症患児の全身麻酔経験, 麻酔, 65, 3, 291-295, 2016.03.
72. 一杉 岳, アイカルディ症候群を伴った女児に対する2度の全身麻酔経験, 麻酔, 65, 1, 78-81, 2016.01.
73. Shigeki Fujiwara, Akiko Noguchi, Yuichiro Nakamura, Masanori Tsukamoto, Takashi Hitosugi, Takeshi Yokoyama, Diffusion of nitrous oxide through endotracheal tube cuffs, Biomedical Research, 27, 1, 40-45, 2016.01, During general anesthesia using nitrous oxide (N2O), N2O diffuses into the tracheal tube cuff and increases cuff pressure, potentially causing tissue damage in the trachea. However, the permeability of the tube cuff to N2O flowing into the cuff is unknown. Here, we examined decrease in cuff pressure and N2O permeability of the tracheal tube cuff. Two tracheal tubes, i.e., Portex Blue Line Profile, Soft-Seal Cuff (SPN) and Mallinckrodt Nasal RAE Tracheal Tube Cuffed, Murphy Eye (MRN), were examined. Six gas samples (air, oxygen, 70% N2O in oxygen, 50% N2O in oxygen, 30% N2O in oxygen, and a mixture of 60% N2O in oxygen to air [4:3]) were prepared and used to inflate both cuffs at a pressure of 30 cmH2O. Cuff pressures were recorded at every 5 min. After inflation with air, cuff pressures reached 26.8 ± 1.9 and 30.0 cmH2O for MRN and SPN, respectively, within 60 min. Inflation with 70% N2O dramatically decreased cuff pressures (3.2 ± 0.4 and 5.2 ± 1.1 cmH2O, respectively). The rate of pressure decrease was dependent on the concentration of N2O and was more rapid for MRN than SPN. Inflation with the mixture gas decreased the pressure to 14.8 ± 2.7 and 17.4 ± 3.8 cmH2O for MRN and SPN, respectively, within 60 min. Here, we provided the first analysis of deflating cuff pressures, which may help to predict patterns for cuff pressure deflation in clinical practice. This study model may be beneficial for the study of ventilator-associated pneumonia..
74. Takashi Hitosugi, Masanori Tsukamoto, Kentaro Ishii, Masanori Kadowaki, Shigeki Fujiwara, Takeshi Yokoyama, Repeated anesthesia management in a patient with aicardi syndrome, Japanese Journal of Anesthesiology, 65, 1, 78-81, 2016.01, Aicardi syndrome is a rare hereditary disorder that develops in only girls with the trilogy of nutatory epilepsy, callosal agenesis and chorioretinopathy. We experienced general anesthesia twice for a patient with Aicardi syndrome in addition to heavy mental retardation. She underwent surgical correction for cleft lip and palate at 6 months of age and at 2 years of age, respectively. Anesthesia was induced slowly with inhalation of nitrous oxide, oxygen and sevoflurare. After securing an intravenous route, midazolam, thiopental and vecuronium were administered and intubated orally. Anesthesia was maintained with isoflurane safely. Patients with Aicardi syndrome have a high risk of aspiration pneumonia caused by underdeveloped swallowing ability due to callosal agenesis. We should, therefore, pay attention to prevention of seizure and aspiration pneumonia during the perioperative period..
75. Takashi Hitosugi, Masanori Tsukamoto, Rika Shiba, Sayuri Koyama, Takeshi Yokoyama, Anesthetic management of a patient with Williams syndrome, Journal of Japanese Dental Society of Anesthesiology, 44, 2, 150-152, 2016, A 9-year-old boy with Williams syndrome was scheduled to receive dental treatment under general anesthesia. He had been diagnosed as having Williams syndrome based on the presence of characteristic features, including an elfin face, mental retardation, and congenital supravalvular aortic stenosis and hypercalcemia. Airway management using a mask technique was easily performed. Anesthesia was induced slowly with the inhalation of oxygen and sevoflurane. After obtaining an intravenous route, fentanyl and rocuronium were administered and the patient was intubated nasally. Tracheal intubation (using an Airway Scope®) was performed. The anesthesia was safely maintained using sevoflurane. Patients with Williams syndrome have a high risk of sudden death caused by arrhythmias or cardiac arrest. Therefore, special care to prevent heart failure during the perioperative period using a noninvasive hemodynamic monitor and appropriate management of the circulatory system, mental retardation, malignant hyperthermia, and hypercalcemia is needed in patients with this syndrome..
76. Masanori Tsukamoto, Rika Shiba, Sayuri Koyama, Takashi Hitosugi, Takeshi Yokoyama, Anesthetic management for dental treatment in a special needs patient with tracheal granulation tissue, Journal of Japanese Dental Society of Anesthesiology, 44, 2, 180-182, 2016, We report the anesthetic management during dental treatment under general anesthesia using a flexible laryngeal mask airway (FLMA) in a patient with tracheal granulation tissue. The patient was a 7-year-old boy with cerebral palsy and tracheal granulation tissue after a tracheotomy. A physical examination revealed the patient to weight 17 kg and to have a height of 107 cm. He could not walk by himself, and he required total support because of a low level of activity. Anesthesia was induced by the inhalation of 8% sevoflurane and oxygen (6 l/min) after the start of SpO2 monitoring. After the loss of consciousness, the inhalation anesthetics were switched to 2%-3% sevoflurane, and BP, ECG, and BIS monitoring were initiated. A size 2.5 FLMA was easily inserted after the administration of atropine (0.1 mg). The anesthesia was maintained with sevoflurane in oxygen (FiO2 : 0.47) and air with acetoaminophen. In the surgical field, the rubber dam isolation technique was used to prevent contamination (saliva, hemorrhage). The pressure control ventilation setting was used throughout the procedure, and no episodes of desaturation occurred. The patient awakened fully after the anesthesia and his respiratory and hemodynamic conditions stabilized after extraction. The use of FLMA should be considered to avoid unexpected airway troubles during dental treatment in patients with tracheal granulation tissue..
77. Masanori Tsukamoto, Takashi Hitosugi, Takeshi Yokoyama, Anesthetic management of a dental patient with repeated convulsions and difficult airway management, Journal of Japanese Dental Society of Anesthesiology, 43, 5, 664-666, 2015, We treated a special-needs dental patient with epilepsy. Convulsions without changes in the Bispectral Index (BIS®) were observed during the dental treatment, and a severe airway obstruction occurred after extubation. The patient was a 15-year-old boy with well-controlled epilepsy, cerebral palsy, and intellectual disability. On physical examination, he was 17 kg in weight and 109 cm in height. He could not walk by himself, and he had experienced frequent episodes of reduced SpO2 at meal times, probably because of weak pharyngeal muscles and increased secretion. For the dental treatment, anesthesia was induced with the inhalation of sevoflurane (8%) in nitrous oxide (4 l/min) and oxygen (2 l/min) after the start of SpO2 monitoring. Once the patient was unconscious, the inhaled anesthetics were changed to isoflurane (1%) in oxygen (6 l/min), and blood pressure monitoring, electrocardiography, and BIS monitoring were started. We administered rocuronium (10 mg), atropine (0.1 mg) and fentanyl (30 μg) after confirming easy mask ventilation. The patient was intubated with a 5.5-mm nasotracheal tube by direct laryngoscopy. A convulsion lasting five seconds occurred when the patient's throat was packed with gauze. In addition, convulsions occurred several times during the dental treatment when the teeth were shaved. Remifentanil, but not propofol, was useful for preventing the convulsions. The cause of the convulsions might have been small stimulations, such as vibrations, which were difficult to control using local anesthesia. After extubation, an upper airway obstruction occurred, probably because of the patient's weakened peripharyngeal muscles, delayed awakening from anesthesia, and increased secretion. Therefore, the patient was re-intubated until the following day. The history of complications and present condition of patients should be considered when managing unexpected troubles during the perioperative period..
78. 佐古 沙織, 一杉 岳, 加留部 紀子, 伊藤田 翔子, 横山 武志, 両肺挫傷および左肺気胸を合併した患児の右側頬骨骨折整復術の麻酔管理., 臨床麻酔, 36, 1089-1090, 2012.12.
79. 表 武典, 全 奈穂, 加留部 紀子, 伊藤田 翔子, 原田 知佳子, 徳田 涼子, 一杉 岳, 坂本 英治, 横山 武志, 予期せず口腔内セネストパチーに星状神経節ブロック療法が有効であった1例., 日本歯科麻酔学会雑誌, 40, 243-244, 2012.08.
80. Takenori Omote, Naho Zen, Noriko Karube, Shoko Itoda, Chikako Harada, Ryouko Tokuda, Takashi Hitosugi, Eiji Sakamoto, Takeshi Yokoyama, A case of stellate ganglion block therapy unexpectedly effective for oral cenestopathy, Journal of Japanese Dental Society of Anesthesiology, 40, 2, 243-244, 2012.
81. Tomoe Iwabuchi, Toshiyuki Saito, Toshiyasu Kitayama, Takashi Hitosugi, Sono Suzuki, Yoshiyuki Oi, A nasotracheal tube introducer that minimizes damage on nasopharyngeal membranes, Journal of Japanese Dental Society of Anesthesiology, 36, 3, 294-297, 2008.08, We usually choose nasal intubation in oral surgical procedures to provide sufficient oral cavity space for the surgeon. During nasal intubation procedure, the tip of the nasotracheal tube is advanced in the nasal cavity blindly. There are a number of reports of epistaxis, palatal perforation, perforation of cervical esophagus, obstruction by bleeding and dislocation of middle turbinate into the nasopharynx. We therefore developed a new nasotracheal tube with a balloon-tip introducer to decrease the complications and trauma to the nasopharyngeal membranes (Fig. 1). Five anesthetists participated to test this device using the Laerdal Airway Management Trainer® The process of nasotracheal intubation was as follows : Insertion of the inflatable balloon introducer into the nasotracheal tube was done. Let one fourth of the balloon protrude from the distal tip of the nasotracheal tube. After advancing the nasotracheal tube blindly through the nasopharynx until its tip is in the midpharyngeal cavity behind the fauces, the balloon is deflated and then, the balloon introducer is pulled out from the tube. The nasotracheal tube is further advanced and placed into the trachea using Magill forceps. We obtained satisfactory results using our new device on the Laerdal Model Trainer®. There was less resistance during insertion of the nasotracheal tube (Mallinckrodt®) when compared with that of the conventional tracheal tube. We believe that it is crucial to perform smooth insertion of the nasotracheal tube to minimize trauma on the nasopharyngeal membranes..
82. 岩渕 知恵, 齋藤 敏之, 北山 稔恭, 一杉 岳, 鈴木 素野, 大井 良之, スムーズに挿入できるバルーン付き経鼻挿管チューブの開発., 日本歯科麻酔学会雑誌, 36, 294-297, 2008.08.
83. Takashi Hitosugi, Toshiyuki Saito, Sono Suzuki, Ieko Kubota, Emi Shoda, Toru Shimizu, Yoshiyuki Oi, Hydroxyethyl starch The effect of molecular weight and degree of substitution on intravascular retention in vivo, Anesthesia and Analgesia, 10.1213/01.ane.0000275198.84094.ad, 105, 3, 724-728, 2007.09, [URL], BACKGROUND: Hydroxyethyl starch (HES) solution is characterized by its mean molecular weight (MW), concentration, and degree of substitution (DS). This character varies worldwide. METHODS: After binding fluorescein-isothiocyanate (FITC-HES), we evaluated the retention rate of three types of 6% HES in the A2 and V2 blood vessels of rat cremaster muscles using intravital microscopy in a mild hemorrhage model (10% of total blood volume). After blood withdrawal, we infused three types of FITC-HES: HES-A (MW 150-200 kDa, DS 0.6-0.68), HES-B (MW 175-225 kDa, DS 0.45-0.55), or HES-C (MW 550-850 kDa, DS 0.7-0.8) before determining the FITC-HES retention rate in the intravital microscope. RESULTS: For V2, the FITC-HES retention rates 120 min after the start of the infusion were 27% ± 7.2% of baseline values (HES-A), 65% ± 9.1% (HES-B), and 86% ± 9.6% (HES-C); for A2 they were 27% ± 6.6%, 73% ± 10.2%, and 89% ± 8.7%, respectively. HES-B and HES-C were retained in the vessels longer than HES-A (P = 0.028 for V2, P = 0.038 for A2 between HES-B and HES-A; P = 0.022 for V2, P = 0.037 for A2 between HES-C and HES-A). There was no difference in the rate of disappearance from the vessels between HES-B and HES-C. CONCLUSIONS: HES-B and HES-C are equally retained in the blood vessels. Middle-sized HES-B with low DS and middle substitution pattern stayed in the blood vessels as long as the large-sized HES. HES solutions of varying characters should be examined to optimize HES infusion..
84. 一杉 岳*, 大井 良之, 分子量、置換度値の異なるhydroxyethyl starch(HES)の出血性ショック時における経時的微小血管内停滞率の比較., 81, 35-38, 2007.08.
85. 一杉 岳*, 鈴木 素野, 正田 絵美, 久保田 伊柄子, 清水 亨, 斉藤 敏之, 大井 良之, 分子量、DS値の異なるHydroxyethyl starch(HES)の経時的微小血管内停滞率の比較., 体液・代謝管理, 22, 91-95, 2006.08.
86. 酒向 誠, 村田 千年, 一杉 岳, 小柳 一哉, 本橋 雪子, 村瀬 博文, 口底部に発生した成人型横紋筋腫の1例., 日本口腔外科学会雑誌, 52, 77-80, 2006.08.
87. 鈴木 素野, 一杉 岳*, 正田 絵美, 久保田 伊柄子, 清水 亨, 斉藤 敏之, 大井 良之, 血液ガス分析による重炭酸リンゲル液(ビカーボン注)と既存の各輸液との自発呼吸下ラットにおける比較評価., 22, 75-81, 2006.04.
88. 岩永 知大, 山崎 陽子, 山口 顕広, 内田 琢也, 一杉 岳, 岡 俊一, 大井 良之, 笑気吸入鎮静法施行中における室内汚染笑気濃度の測定および検討., 34, 520-521, 2006.04.
89. 久保田 伊柄子, 正田 絵美, 一杉 岳, 鈴木 素野, 坪井 美行, 大井 良之, 岩田 幸一, プロポフォールは三叉神経脊髄路核ニューロン活動を増強する. Fos免疫染色法による検討., 日本歯科麻酔学会雑誌, 34, 478-484, 2006.04.
90. Ieko Kubota, Emi Shoda, Takashi Hitosugi, Sono Suzuki, Yoshiyuki Tsuboi, Yoshiyuki Oi, Koichi Iwata, Intravenous administration of propofol causes an increase in trigeminal spinal nucleus neuronal activity in rats
Fos analysis, Journal of Japanese Dental Society of Anesthesiology, 34, 5, 478-484, 2006, Propofol is one of the most widely used sedative agents in the clinic. It has a strong sedative effect but no analgesic effect. However, the neuronal mechanism underlying the lack of analgesic effect during propofol administration is not known. Fos expression in the trigeminal spinal nucleus neurons was precisely analyzed following intravenous injection of propofol at different sedative levels. Sprague-Dawley rats were divided into two groups (light and deep sedative levels) based on the electroencephalogram (EEG) analysis. The rats were perfused, their brainstems were removed, and Fos immunohistochemistry was performed. We also infused lidocaine into the jugular vein to test whether propofol directly activates the nociceptors innervated in the vein. Many Fos protein-LI cells were expressed in the trigeminal spinal nucleus interpolaris and caudalis transition zone (Vi/Vc zone) and caudal Vc with two peaks. The number of Fos protein-LI cells was significantly greater in Vi/Vc zone at the deep level compared with that of light level. The Fos expression in Vi/Vc zone was significantly depressed following pretreatment with iv infusion of lidocaine before propofol administration. These results suggest that intravenous injection of propofol is involved in the increased activity of trigeminal spinal nucleus neurons, resulting in the central sensitization of the trigeminal pain pathways. It is also suggested that the intravenous nociceptors would be involved in an increment of the Vc neuronal activity..
91. Saito Toshiyuki, Tamatsukuri Yoshiki, Hitosugi Takashi, Miyakawa Kunihisa, Shimizu Toru, Oi Yoshiyuki, Yoshimoto Masami, Yamamoto Yoshiyuki, Spanel-Browski Katherina, Dipl-Ing Hanno Steinke, Three Cases of Retroesophageal Right Subclavian Artery, Journal of Nippon Medical School, 72, 6, 375-382, 2005.12.
92. 酒向 誠, 村田 千年, 佐藤 直之, 一杉 岳, 本橋 雪子, 村瀬 博文, AA蛋白による舌アミロイドーシスが先行症状であった多発性骨髄腫の1例., 日本口腔外科学会雑誌, 50, 616-619, 2004.04.
93. 一杉 岳*, 村瀬 博文, 閉鎖性睡眠時無呼吸症候群に対するマウスピース療法は新しい有効な治療法である., 聖路加健康科学誌, 11, 25-28, 2003.06.

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