Kyushu University Academic Staff Educational and Research Activities Database
List of Papers
Fumie TERAO Last modified date:2021.06.28

Assistant Professor / Division of Oral Health, Growth and Development / Department of Dental Science / Faculty of Dental Science

1. Yassin AS, Hoshi K, Terao F, Umeda M, Takahashi I, The role of miRNA-200 in the early stage of the mandibular development., Orthod Waves,, 76, 4, 197-206, 2017.12.
2. Mariko Umeda, Fumie TERAO, Kanako MIYAZAKI, Keigo Yoshizaki, Ichiro Takahashi, MicroRNA-200a Regulates the Development of Mandibular Condylar Cartilage, Journal of Dental Research, 10.1177/0022034515577411, 2015.05, Mandibular condylar cartilage (MCC) is classified as secondary cartilage, the histologic structure of which is unique from that of primary cartilage. MicroRNA (miRNA) is a small noncoding RNA that binds to the messenger RNA (mRNA) target to repress its translation and plays an important role in cell differentiation, proliferation, and death. Microarray analysis revealed that miR-200a was characteristically expressed during embryonic development. We hypothesized that miR-200a may be involved in regulating the formation of cartilage during MCC growth. We investigated the function of miR-200a by transfecting an inhibitor or mimic into MCC organ and cell cultures. A histologic examination revealed the localized inhibitory effects of the miR-200a mimic and widespread enhancing effects of the inhibitor on chondrocytic differentiation in the MCC organ culture system. An immunohistochemical examination and gene expression analysis demonstrated that the miR-200a inhibitor enhanced chondrogenesis, while the mimic had the opposite effect by enhancing cell proliferation. Quantitative reverse transcription polymerase chain reaction analysis revealed that miR-200a downregulated the gene expression of chondrocyte markers. Moreover, transfection of the miR-200a mimic into ATDC5 cells repressed the formation of the cartilaginous matrix. These results indicate that miR-200a contributed to chondrogenesis in developing MCC by controlling proliferation and differentiation in MCC cells..
3. Toru DEGUCHI, Fumie TERAO, Tomo AONUMA, Tomoki KATAOKA, Yasuyo SUGAWARA, Takashi YAMASHIRO, Teruko TAKANO-YAMAMOTO, Outcome assessment of lingual and labial appliances compared with cephalometric analysis, peer assessment rating, and objective grading system in Angle Class II extraction cases, The Angle Orthodontist,, 2014.05, Objective: To validate our hypothesis that there would be significant differences in treatment outcomes, including cephalometric values, degree of root resorption, occlusal indices, and functional aspect, between cases treated with labial and lingual appliances.
Materials and Methods: Twenty-four consecutively treated Class II cases with extractions and lingual appliance were compared with 25 matched cases treated with extraction and labial appliance. Orthodontic treatment outcomes were evaluated by cephalometric analysis, peer assessment rating, and an objective grading system (OGS). Additionally, functional analysis was also performed in both groups after orthodontic treatment. Statistical comparison was performed using the Wilcoxon signed rank test within the groups, and the Mann-Whitney U-test was used to compare between the labial and lingual groups.
Results: The only significant difference between the groups was that the interincisal angle was larger in the lingual group than in the labial group. OGS evaluation showed that control over root angulation was significantly worse in the lingual group than in the labial group. There was no significant difference between groups in the amount of root resorption or in functional evaluation.
Conclusions: Generally, lingual appliances offer comparable treatment results to those obtained with labial appliances. However, care should be taken with lingual appliances because they are more prone to produce uprighted incisors and root angulation..
4. Terao F, Takahashi I, Mitani H, Haruyama N, Sasano Y, Suzuki O, Takano-Yamamoto T., Fibroblast growth factor 10 regulates Meckel’s cartilage formation during early mandibular morphogenesis in rats. , Developmental Biology, 10.1016/j.ydbio.2010.11.029, 350, 2, 337-347, 2011.02.
5. Takahashi I, Terao F, Suzuki M, Kawamura H, Takano-Yamamoto T., Mandibular body lengthening by distraction osteogenesis for correction of skeletal class II problems with an impacted premolar., J Oral Maxillofac Surg., doi:10.1016/j.joms.2010.05.058., 68, 11, 2893-2902, 2010.11.
6. Shimonishi M, Takahashi I, Terao F, Komatsu M, Kikuchi M. , Induction of MMP-2 at the interface between epithelial cells and fibroblasts from human periodontal ligament., Journal of Periodontal Research, 10.1111/j.1600-0765.2009.01237.x, 45, 3, 309-316, 2010.06.