九州大学 研究者情報
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基本情報 研究活動 教育活動 病院臨床活動
吉武 忠正(よしたけ ただまさ) データ更新日:2020.04.23

講師 /  九州大学病院 放射線科 九州大学大学院医学研究院臨床放射線科学分野


主な研究テーマ
脳腫瘍に対する放射線治療
キーワード:脳腫瘍、放射線治療
2015.06~2021.03.
肺癌に対する体幹部定位照射に関する臨床研究
キーワード:定位照射、肺癌
2010.04~2013.03.
研究業績
主要著書
1. 吉武忠正, 塩山善之, 2010別冊 代表的照射野とCT上のターゲット, p150-151, 2010.12.
主要原著論文
1. Inoue T, Katoh N, Ito YM, Kimura T, Nagata Y, Kuriyama K, Onishi H, Yoshitake T, Shioyama Y, Iizuka Y, Inaba K, Konishi K, Kokubo M, Karasawa K, Kozuka T, Tanaka K, Sakakibara-Konishi J, Kinoshita I, Shirato H., Stereotactic body radiotherapy to treat small lung lesions clinically diagnosed as primary lung cancer by radiological examination: A prospective observational study., Lung Cancer, 2018.08.
2. Yoshitake T, Nakamura K, Shioyama Y, Nomoto S, Ohga S, Toba T, Shiinoki T, Anai S, Terashima H, Kishimoto J, Honda H, Breath-hold monitoring and visual feedback for radiotherapy using a charge-coupled device camera and a head-mounted display: system development and feasibility., Radiat Med, 26, 1, 50-5, 2011.07.
3. Yoshitake T, Shioyama Y, Nakamura K, Ohga S, Nonoshita T, Ohnishi K, Terashima K, Arimura H, Hirata H, Honda H, A clinical evaluation of visual feedback-guided breath-hold reproducibility of tumor location, Phys Med Biol, 54, 23, 7171-82, 2009.07.
4. 吉武忠正, 塩山善之, 中村和正, 野元諭, 樋渡昭雄, 吉浦敬, 平田秀紀, 松本俊一, 溝口昌弘, 庄野禎久, 佐々木富男, 本田浩, 膠芽腫の放射線治療後の増悪形式とその無増悪期間、生存期間との関連について, 臨床放射線, 54, 5, 631-636, 2009.07.
5. Yoshitake T, Nakamura K, Shioyama Y, Sasaki T, Ooga S, Abe M, Urashima Y, Urabe K, Terashima H, Honda H, Erythema multiforme and Stevens-Johnson syndrome following radiotherapy, Radiat Med, 25, 1, 27-30, 2007.07.
6. Yoshitake T, Nakamura K, Shioyama Y, Sasaki T, Ohga S, Yamaguchi T, Toba T, Anai S, Terashima H, Honda H, A machine vision system with CCD cameras for patient positioning in radiotherapy: a preliminary report, Fukuoka Igaku Zasshi, 96, 12, 399-405, 2005.07.
主要総説, 論評, 解説, 書評, 報告書等
主要学会発表等
1. Tadamasa Yoshitake, Saiji Ohga, Satoshi Nomoto, Toshihiro Yamaguchi, Kaori Asai, Hidenari Hirata, Osamu Hisano, Yushi Motomura, Akio Hiwatashi, Koji Yoshimoto, Hiroshi Honda, High pre-treatment neutrophil-to-lymphocyte ratio predicts poor survival in patients with glioblastoma treated with radiotherapy and temozolomide, ASTRO2016, 2016.09.
2. 吉武 忠正, Incidence of radiation pneumonitis after multiple courses of stereotactic body radiation therapy for lung cancer patients, ASTRO, 2014.09.
3. Tadamasa Yoshitake, Yoshiyuki Shioyama, Katsumasa Nakamura, Tomonari Sasaki, Ohga Saiji, Hideki Hirata, Hiroshi Honda, Stereotactic body radiation therapy for primary lung cancers which were clinically diagnosed without pathological confirmation: a single-institution experience, RSNA, 2012.11, Purpose
Pathological diagnosis of small lung lesions is sometimes difficult in inoperable patients. The purpose of the present study was to evaluate the outcome of stereotactic body radiotherapy (SBRT) for small lung lesions that are clinically diagnosed as primary lung cancer without pathologic confirmation.

Materials and methods
Between April 2003 and July 2011, 82 patients with small pulmonary lesions clinically diagnosed as primary lung cancer were treated with SBRT in Kyushu University Hospital. The median age of the 66 patients was 75 years (range 51- 92 years). Forty four patients were male, and 38 were female. The median tumor size was 19 mm (range 8-40 mm). Thin-section CT findings for these pulmonary lesions showed solid nodules and ground-glass opacity (GGO) nodules in 53 and 29 patients, respectively. The radiation dose was 48 Gy in 4 fractions in all patients.

Results
Median follow-up was 20 months (range 6-83 months). Recurrence was observed in 13 (15.9%) patients (local failure, 6; regional failure, 5; distant metastases, 6) with solid nodules. There was no recurrence in 29 patients with GGO nodules. Two patients died of recurrence and 10 patients died from other diseases. Local control rate, cause-specific survival and overall survival at 3 years were 88%, 98% and 79%, respectively. Two (2.4%) patients and 5 (6.1%) patients had grade 2 radiation pneumonitis and grade 2 rib fracturing, respectively. There were no adverse effects of grade 3 or greater during follow-up.

Conclusions
SBRT is to be considered a safe and effective treatment option for small lung lesions clinically diagnosed as primary lung cancer without pathologic confirmation, especially in patients with GGO nodules.
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4. 吉武 忠正, 塩山 善之, 大賀 才路, 野々下 豪, 大西 かよ子, 浅井 佳央里, 松本 圭司, 中村和正, 平田秀紀, 本田 浩 , 在宅酸素療法中の原発性肺癌患者に対する体幹部定位放射線治療, 日本放射線腫瘍学会学術大会第23回学術大会, 2010.11.
5. Yoshitake T, Shioyama Y, Nakamura K, Ohga S, Nonoshita T, Ohnishi K, Asai K, Matsumoto K, Hirata H, Honda H., Dosimetric evaluation in stereotactic radiotherapy for pulmonary ground-glass opacity nodules: The relationship with calculation algorithm and dose prescription methods., Radiological Society of North America, 2010.12.
学会活動
所属学会名
日本放射線腫瘍学会
日本医学放射線学会
日本癌治療学会
学会大会・会議・シンポジウム等における役割
2011.06.04~2011.06.05, 第173日本医学放射線学会九州地方会, 座長(Chairmanship).
学術論文等の審査
年度 外国語雑誌査読論文数 日本語雑誌査読論文数 国際会議録査読論文数 国内会議録査読論文数 合計
2009年度      
受賞
日本放射線腫瘍学会第19回学術大会 優秀発表賞(総合), 日本放射線腫瘍学会, 2006.11.
研究資金
科学研究費補助金の採択状況(文部科学省、日本学術振興会)
2018年度~2020年度, 基盤研究(C), 代表, 深層学習を用いた転移性脳腫瘍の予後予測と放射線治療方針決定システムの開発.
2014年度~2016年度, 基盤研究(C), 代表, 近似症例検索エンジンを用いた放射線治療計画支援システムの開発.

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