九州大学-研究者情報 [伊原栄吉 (准教授) 医学研究院臨床医学部門]

食道アカラシアの病態解明に関する研究
キーワード：食道アカラシア
2023.04～2023.10.

食道運動異常症に病態解明と新規治療薬の開発
キーワード：食道運動異常症、高解像度食道運動機能検査
2016.04～2021.03.

下部食道括約筋の緊張調節機序の解明
キーワード：下部食道括約筋、収縮機序、筋源性緊張調節、Rhoキナーゼ
2016.04～2021.03.

胃食道逆流症の病態に関する研究
キーワード：高解像度食道内圧検査、食道内pH/インピーダンス測定、胃食道逆流症、食道運動異常症
2016.04～2021.03.

種々の消化管疾患に伴う腸管炎症が、腸管平滑筋収縮性を変化させ、腸管運動機能障害を引き起こす機序解明。　　　　　　
キーワード：腸管運動機能障害、腸管平滑筋収縮、腸管炎症
2016.04～2021.03.

主要著書

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主要原著論文

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1.	Hamada, Shohei; Ihara, Eikichi; Ikeda, Hiroko; Muta, Kazumasa; Ogino, Haruei; Chinen, Takatoshi; Tanaka, Yoshimasa; Ogawa, Yoshihiro, Clinical Characterization of Vonoprazan-Refractory Gastroesophageal Reflux Disease, DIGESTION, 10.1159/000503340, 102, 2, 197-204, 2021.02.
2.	Minoda, Yosuke; Ihara, Eikichi; Komori, Keishi; Ogino, Haruei; Otsuka, Yoshihiro; Chinen, Takatoshi; Tsuda, Yasuo; Ando, Koji; Yamamoto, Hidetaka; Ogawa, Yoshihiro, Efficacy of endoscopic ultrasound with artificial intelligence for the diagnosis of gastrointestinal stromal tumors, JOURNAL OF GASTROENTEROLOGY, 10.1007/s00535-020-01725-4, 55, 12, 1119-1126, 2020.12.
3.	Keita Fukaura, Yoichiro Iboshi, Haruei Ogino, Eikichi Ihara, Kazuhiko Nakamura, Yuichiro Nishihara, Kei Nishioka, Takatoshi Chinen, Tsutomu Iwasa, Akira Aso, Ayako Goto, Kazuhiro Haraguchi, Hirotada Akiho, Naohiko Harada, Yoshihiro Ogawa, Mucosal Profiles of Immune Molecules Related to T Helper and Regulatory T Cells Predict Future Relapse in Patients with Quiescent Ulcerative Colitis, Inflammatory bowel diseases, 10.1093/ibd/izy395, 25, 6, 1019-1027, 2019.05, [URL], Background: T helper (Th)- and regulatory T (Treg) cell-related immune molecules are implicated in ulcerative colitis (UC). However, the association between their mucosal expression during remission and the subsequent clinical course of UC is unknown. Methods: The expression of cytokines and transcription factors related to Th1, Th2, Th17, and Treg in endoscopic mucosal biopsy specimens from 40 UC patients in clinical remission and 9 controls was measured by quantitative polymerase chain reaction. The relationship between their expression patterns, as stratified by Mayo Endoscopic Subscore (MES), and any future relapse was evaluated by univariate and multivariate analyses. Results: Six of 40 patients (baseline MES 0/1/2, 22/14/4) experienced a relapse during the study period (median, 37 months). At baseline, even in the MES0 patients, the interleukin (IL)-17A of the patients was significantly upregulated in comparison with controls (P = 0.0351). Future relapse was associated with a higher baseline expression of IL-17A, IL-17F, and IL-21 in MES0/1, and the upregulation of IL-17F and IL-21 remained statistically significant when limited to MES0 patients. Kaplan-Meier analysis revealed that as a single marker, a higher IL-21 level best grouped patients with an increased risk of relapse (P = 0.0042). Furthermore, a multivariate model that consisted of IL-21 and T-bet showed an even greater value (P = 0.0001). Conclusions: The profiles of Th/Treg-related gene expression in the colonic mucosa are altered, even during clinical and endoscopic remission of UC, with a detectable Th17-predominant profile predicting future relapse. This association might represent latent immune dysregulation during disease quiescence and has the potential to be utilized to improve patient care..
4.	Bai Xiaopeng, Yoshimasa Tanaka, Eikichi Ihara, Katsuya Hirano, Kayoko Nakano, Mayumi Hirano, Yoshinao Oda, Kazuhiko Nakamura, Trypsin induces biphasic muscle contraction and relaxation via transient receptor potential vanilloid 1 and neurokinin receptors 1/2 in porcine esophageal body, European Journal of Pharmacology, 10.1016/j.ejphar.2017.01.004, 797, 65-74, 2017.01, [URL].
5.	Ihara E, Chappellaz M, Turner SR, MacDonald JA, Contribution of Protein kinase C and CPI-17 signaling pathways to hypercontractility in murine experimental colitis. , Neurogastroenterol Motil, 24, e15-26, 2012.01.
6.	Ogino H, Nakamura K, Ihara E, Akiho H, Takayanagi R, CD4+CD25+ Regulatory T Cells Suppress Th17-Responses in an Experimental Colitis Model. , Dig Dis Sci , 57, 497-500, 2011.01.
7.	Ihara E, Beck PL, Chappellaz M, Wong J, Medlicott SA and MacDonald JA, Mitogen-activated protein kinase pathways conribute to hypercontractility and increased Ca2+-sensitization in murine experimental colitis. , Mol Pharmacol, 75, 1031-1041, 2009.07.
8.	Ihara E, Hirano K, Hirano M, Nishimura J, Nawata H, Kanaide H, Mechanism of down-regulation of L-type Ca2+ channel in the proliferating smooth muscle cells of rat aorta. , J Cell Biochem, 10.1002/jcb.10295, 87, 2, 242-251, 2002.07.
9.	Ihara E, Hirano K, Derkach DN, Nishimura J, Nawata H, Kanaide H, The mechanism of bradykinin-induced endothelium-dependent contraction and relaxation in the porcine interlobar renal artery. , Br J Pharmacol, 10.1038/sj.bjp.0703141, 129, 5, 943-952, 2000.07.
10.	Derkach DN, Ihara E, Hirano K, Nishimura J, Takahashi S, Kanaide H, Thrombin causes endothelium-dependent biphasic regulation of vascular tone in the porcine renal interlobar artery. , Br J Pharmacol 2000;131, 10.1038/sj.bjp.0703737, 131, 8, 1635-1642, 2000.07.
11.	Ihara E, Hirano K, Nishimura J, Nawata H, Kanaide H, Thapsigargin-induced endothelium-dependent triphasic regulation of vascular tone in the porcine renal artery. , Br J Pharmacol, 10.1038/sj.bjp.0702821, 128, 3, 689-699, 1999.07.

主要総説, 論評, 解説, 書評, 報告書等

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1.	畑佳孝、濱田匠平、和田将史、池田浩子、小森圭司、荻野治栄、伊原栄吉, 【いま知っておきたい食道良性疾患】アカラシアおよび関連疾患の診断　X線の立場から, 2020.07.
2.	伊原　栄吉, 非びらん性胃食道逆流症の病態, BIO Clinica 2018; 33 (4): 319-323, 2018.06.
3.	中村和彦, 井星陽一郎, 伊原栄吉, 炎症性腸疾患におけるT helper反応制御異常., 日本消化器病学会雑誌, 2013.10.
4.	Ihara E, Akiho H, Nakamura K, Turner SR, MacDonald JA, MAPK signaling pathways represent a possible ideal target for generation of novel therapeutics for patients with gastrointestinal motility disorders. , World J Gastrointest Pathophysiol 2:19-25, 2011.07.
5.	Akiho H, Ihara E, Nakamura. K, Low-grade inflammation plays a pivotal role in gastrointestinal dysfunction in irritable bowel syndrome. , World J Gastrointest Pathophysiol 1:97-105, 2010.07.
6.	Ihara E and MacDonald JA, The regulation of smooth muscle contractility by zipper-interacting protein kinase. , Can J Physiol Pharmacol 85: 79-87., 2007.07.

主要学会発表等

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1.	Hata Y, Hamada Y, Wada M, Ikeda H, Komori K, Ogino H, Ihara E, Akiho H, Ogawa Y, Usefulness of barium esophagram with newly developed wave appearance in screening tool for esophageal motility disorders., Digestive Disease Week 2020, 2020.05.
2.	Nishihara Y, Ogino H, Tanaka M, Ihara E, Chinen T, Nishioka K, Ikeda H, Hayashi Y, Okuno H, Fukaura K, Nakayama J, Akiho H, Ogawa Y., Transcriptome analysis reveals that microbiota in the intestinal mucosal is related with the severity and clinical course of ulcerative colitis., Digestive Disease Week 2020, 2020.05.
3.	Ihara E, Muta K, Bai X, Hamada S, Ikeda H, Komori K, Ogino H, Chinen T, and Ogawa Y., Elevation of basal EGJ pressure is associated with low-efficacy of acotiamide for the patients with EGJ outflow obstruction., Digestive Disease Week, 2019.05.
4.	Ikeda H, Ihara E, Hamada S, Muta K, Fukaura K, Otsuka Y, Hata Y, Mukai K, Komori K, Ogino, H Chinen T and Ogawa Y., Impaired esophagogastric junction recessive relaxation plays a central role in esophageal motility disorders associated with systemic scleroderma., Digestive Disease Week, 2019.05.
5.	Hamada S, Ihara E, Muta K, Ikeda H, Mukai K, Otsuka Y, Hata Y, Ogino H, Takatoshi Chinen and Ogawa Y., Significant difference in the proportion of underlying diseases between conventional proton pump inhibitors and vonoprazan refractory gastroesophageal refluc disease., Digestive Disease Week, 2019.05.
6.	Bai X, Ihara E, Otsuka Y, Ogino H, Akiho H, Nakamura K and Ogawa Y., Nicotine caused the dual regulation of tone in the porcine lower esophageal sphincter through excitatory and inhibitory enteric innervation., Digestive Disease Week, 2018.06.
7.	Hamada S, Ihara E, Muta K, Fukaura K, Ogino H, Bai X, Mukai K, Otsuka Y, Komori K, Hata Y, Aso A, Iwasa T, Ochiai T, Akiho H, Nakamura K and Ogawa Y., The esophageal intraluminal baseline impedance differentiates reflux hypersensitivity from NERD., Digestive Disease Week, 2018.06.
8.	Minoda Y, Osoegawa T, Itaba S, Aso A, Iwasa T, Ogino H, Harada N, Ihara E, Nakamura K and Ogawa Y., Endoscopic ultrasound-guided fine needle aspiration v.s. a mucosal incision-assisted biopsy for gastric submucosal tumors: a randomized comparative study., Digestive Disease Week, 2018.06.
9.	Muta K, Ihara E, Hamada S, Fukaura K, Bai X, Otsuka Y, Ogino H, Bai X, Mukai K, Komori K, Hata Y, Mukai K, Komori K, Iwasa T, Akiho H, Nakamura K and Ogawa Y., Mucosally expressed protease-activated receptor2 and transient receptor potential vanilloid1 are associated with functional heartburn., Digestive Disease Week, 2018.06.
10.	Muta K, Ihara E, Fukaura K, Bai X, Hata Y, Ogino H, Ochiai T, Nakamura K and Ogawa Y., Both incomplete LES relaxation and premature contraction of esophageal body are characteristics of dry swallow., Digestive Disease Week, 2018.06.
11.	Otsuka Y, Bai X, Ihara E, Kazuhiko Nakamura, Ogawa Yoshihiro, Rho kinase-associated myogenic contraction compensates for reduced force induced by release after stretching in the porcine lower esophageal sphincter., Digestive Disease Week 2017, 2017.05.
12.	Hata Y, Ihara E, Fukaura K, Muta K, Bai X, Tsutomu Iwasa, Aso A, Kazuhiko Nakamura, Ogawa Yoshihiro, Esophagogastric junction outflow obstruction is discriminated from achalasia by esophageally expressed cytokine profiles using linear discriminant analysis., Digestive Disease Week 2017, 2017.05.
13.	Muta K, Ihara E, Fukaura K, Bai X, Ochiai T, Tsutomu Iwasa, Aso A, Kazuhiko Nakamura, Lower esophageal sphincter (LES) receptive relaxation is indispensable for successful LES relaxation in wet swallowing., Digestive Disease Week 2017, 2017.05.
14.	牟田和正, 伊原栄吉, 深浦敬太, 白暁鵬, 中村和彦, 食道胃接合部通過障害では下部食道括約筋の受容性弛緩反応が障害されている。, 第58回日本平滑筋学会総会, 2016.08.
15.	白暁鵬, 田中義将, 伊原栄吉, 平野勝也, 平野真弓, 中村和彦, プロスタグランジンE2がブタ食道平滑筋に引き起こす収縮及び弛緩反応の機序, 第58回日本平滑筋学会総会, 2016.08.
16.	Muta K, Ihara E, Fukaura K, Bai X, Tanaka Y, Iwasa T, Aso A, Tsuchida O, Ochiai T, Kazuhiko Nakamura, Mechanisms of acotiamde-sensitive impaired lower esophageal sphincter accommodation in patients with esophagogastric junction outflow obstruction. , Digestive Disease Week 2016, 2016.05.
17.	Bai X, Ihara E, Tanaka Y, Hirano K, Hirano M, Kazuhiko Nakamura, Involvement of different subtypes of receptor in prostaglandin E2-induced motile function in lower esophageal sphincter and esophageal body smooth muscle. , Digestive Disease Week 2016, 2016.05.
18.	Bai X, Ihara E, Tanaka Y, Hirano K, Hirano M, Kazuhiko Nakamura, Akiho H, Trypsin induced a transient contraction via a PAR2/TRPV1/neurokinin receptors pathway in circular smooth muscle of porcine esophageal body., Digestive Disease Week 2016, 2016.05.
19.	Ihara E, Fukaura K, Muta K, Tanaka Y, Bai X, Iwasa T, Aso A, Akiho H, Kazuhiko Nakamura, Protease-activated receptor expression in the esophagus is associated with esophageal mucosal integrity and esophageal motility function., Digestive Disease Week 2016, 2016.05.
20.	伊原栄吉, 牟田和正, 深浦敬太, 田中義将, 白暁鵬, 向井康二, 中村和彦, 当院における食道生理機能検査による難治性GERDの病態解析：治療戦略と現状の問題点, 第102回日本消化器病学会総会, 2016.04.
21.	伊原栄吉, 牟田和正, 深浦敬太, 向井康二, 中村和彦, 高解像度食道内圧検査に基づいたアカラシアおよび食道胃接合部通過障害に対する当科の治療戦略, 第12回日本消化管総会学術集会, 2016.02.
22.	伊原栄吉, 田中義将, 中村和彦, 食道運動機能に関連する臨床的特徴の検討, 第57回日本消化器病学会大会, 2015.10.
23.	伊原栄吉, 深浦敬太, 牟田和正, 田中義将, 白暁鵬, 中村和彦, 食道粘膜におけるprotease-activated receptors (PARs)の発現と食道機能, 第89回日本消化器内視鏡学会総会, 2015.05.
24.	Muta K, Ihara E, Fukaura K, Bai X, Tanaka Y, Nakamura K, Ochiai T, Tsuchida O, Akiho H, Takayanagi R, Actiamide has the potential to become a promising treatment for patients with esophagogastric junction outflow obstruction., Digestive Disease Week 2015, 2015.05.
25.	Tanaka Y, Ihara E, Muta K, Fukaura K, Mukai K, Bai X, Nakamura K, Akiho H, Takayanagi R, Clinical characteristics associated with function of esophageal motility: A retrospective analysis of 97 patients., Digestive Disease Week 2015, 2015.05.
26.	Fukaura K, Ihara E, Muta K, Tanaka Y, Bai X, Nakamura K, Takayanagi R, The cytokine expression patterns of esophageal mucosa are associated with esophageal motility function in human., Digestive Disease Week 2015, 2015.05.
27.	Bai X, Ihara E, Tanaka Y, Hirano K, Hirano M, Akiho H, Nakamura K, Takayanagi R, Endogenous H2S contributes to myogenic tone generation in lower esophageal sphincter: Possible involvement of Na+/Ca2+ exchanger., Digestive Disease Week 2015, 2015.05.
28.	伊原栄吉, 牟田和正, 中村和彦, 高解像度食道内圧検査に基づいた食道運動異常症に対する当科の治療戦略と問題点 , 第101回日本消化器病学会総会, 2015.04.
29.	牟田和正, 伊原栄吉, 中村和彦, 機能性ディスペプシアに合併する食道運動異常症とアコチアミドの効果 , 第101回日本消化器病学会総会, 2015.04.
30.	Ihara E, Fukaura K, Muta K, Tanaka Y, Bai X, Kazuhiko Nakamura, Ryoichi Takayanagi, Expression levels of cytokines, including IL-23, IL-1β, and IFN-γ, in esophageal mucosa are strongly predictive of esophageal body contractility in human., Canadian Digestive Disease Week, 2015.03.
31.	Osoegawa T, Ihara E, Kazuhiko Nakamura, Kubo H, Aso A, Niina Y, Sawamura N, Hijioka M, Igarashi H, Ito T, Tanaka M, Ryoichi Takayanagi, Usefulness and safety of endoscopic ultrasonography-guided drainage for postoperative pancreatic fistulas., 22nd United European Gastroenterology Week, 2014.10.
32.	Xiaopeng Bai, Yoshimasa Tanaka, Eikichi Ihara, Katsuya Hirano, Mayumi Hirano, Kazuhiko Nakamura, Hirotada Akiho, Ryoichi Takayanagi, Different contractile and relaxant effects of trypsin in phasic smooth muscle of the esophageal body and the tonic lower esophageal sphincter., Digestive Disease Week, 2014.05.
33.	Kazumasa Muta, Eikichi Ihara, Xiaopeng Bai, Yoshimasa Tanaka, Kazuhiko Nakamura, Hirotada Akiho, Ryoichi Takayanagi, Acotiamide, a novel prokinetic drug reduces both esophageal body contractility and the tone of the lower esophageal sphincter., Digestive Disease Week, 2014.05.
34.	Yoshimasa Tanaka, Eikichi Ihara, Katsuya Hirano, mayumi hirano, Kazuhiko Nakamura, Hirotada Akiho, Ryoichi Takayanagi, Trypsin induced biphasic contraction and relaxation in the porcine lower esophageal sphincter., Digestive Disease Week, 2013.05.
35.	Ihara E, Honda K, Hata Y, Sumida Y, Akiho H, Nakamura K and Takayanagi R., Preoperative tissue sampling of suspected gastric gastrointestinal stromal tumors by mucosal incision assisted biopsy., Digestive Disease Week,, 2012.05.
36.	Hirotada Akiho, Mitsue Nishiyama, Yohei Tokita, Kazuko Satoh, Hirotada Akiho, Kazuhiko Nakamura, Eikichi Ihara, Ryoichi Takayanagi, Masahiro Yamamoto, IL-17 suppresses RGS4 translocation in primary cultured intestinal smooth muscle cells via IκBζ signaling: an indication of a mechanism of IL-17-induced gut hypermotility., Digestive Disease Week 2012, 2012.05.
37.	Kazuko Stoh, Yohei Tokita, Mitsue Nishiyama, Hirotada Akiho, Kazuhiko Nakamura, Eikichi Ihara, Ryoichi Takayanagi, Masahiro Yamamoto, IL-17 is critically involved in post-inflammatory gut hypermotility., Digestive Disease Week 2012, 2012.05.
38.	伊原栄吉, 本田邦臣, 畑佳孝, 隅田頼信, 秋穂裕唯, 中村和彦, GISTと鑑別を要する胃粘膜下腫瘍の組織診断に対する粘膜切開腫瘍直視下生検の有用性の検討, 日本消化器内視鏡学会総会, 2012.05.
39.	秋穂裕唯, 伊原栄吉, 中村和彦, 機能性消化管モデルにおけるIL-17の関与と大建中湯の有効性の検討, 日本消化器病学会総会, 2012.03.
40.	Ihara E, Yu Q, Moffat L, Chappellaz M, MacDonald JA, ERK and p38MAPK regulate myosin light chain phosphatase and contribute to carbachol-induced contraction in rat intestinal smooth muscle. , 36th International Congress of Physiological Sciences, 2009.07.
41.	Hirota SA, Ng J, Ihara E, Li Y, Muruve D, Armstrong GD, Colgan SP, Chung DC, Beck PL and MacDonald JA., Hypoxia Inducible Factor (HIF-1alpha) Plays a Critical Innate Protective Role in Clostridium Difficile (Cdif) Toxin-Induced Intestinal Injury and Inflammation., Digestive Disease Week, May 30 –June 4, 2009), 2009.05.
42.	Horita SA, Ihara E, Ng J, Li Y, Muruve D, MacDonald JA and Beck PL, Pharmacological stabilization of HIF-1alpha is protective in a mouse model of clostridium difficile-associated intestinal inflammation., Canadian Digestive Disease Week, 2009.02.
43.	Ihara E, Beck PL and MacDonald JA, Protein kinase signaling pathways contribute to hypercontractility in murine experimental colitis., Canadian Digestive Disease Week, 2009.02.
44.	Ihara E, Hirota S, Beck PL and MacDonald JA, Up-regulation of HIF-1alpha is associated with augmented Rho-kinase-mediated contraction of ileal smooth muscle following exposure to Clostridium difficile toxins in a mouse ileal loop model. , Digestive Disease Week, 2008.05.
45.	Ihara E, Beck PL and MacDonald JA, Ca2+-sensitization of colonic smooth muscle is altered in a murine experimental colitis model. , Canadian Digestive Disease Week, 2008.02.
46.	Ihara E, Hirota S, Fines K, Beck PL and MacDonald JA, Alterations in the contractile properties of ileal smooth muscle exposed to Clostridium difficile toxins: the involvement of HIF-1alpha. , Canadian Digestive Disease Week, , 2008.02.
47.	Ihara E, Beck PL, and MacDonald JA, Colonic smooth muscle contractile dysfunction in experimental colitis and its underlying mechanisms. , 15th United European Gastroenterology Week, 2007.10.
48.	Ihara E, Walsh MP and MacDonald JA, Protein kinases responsible for Ca2+-independent contraction of intestinal smooth muscle., Canadian Digestive Disease Week, 2007.02.
49.	Ihara E, Borman M, Ostrander J, Walsh MP and MacDonald JA, Exploration of protein kinases responsible for Ca2+-independent, microcystin-induced contraction in intestinal smooth muscle. , Proceedings of the FASEB Summer Conference on Smooth Muscle, 2006.07.
50.	Ihara E, Ochiai T, Harada N and Kabemura T , The Useful Approach to Obstructing or Stenotic Lesions in the Distal Ileum by Retrograde Ileography. , The 10th United European Gastroenterology Week , 2002.10.
51.	Ihara E, Hirano K, Nishimura J and Kanaide H, Endothelium-dependent triphasic regulation of vascular tone induced by bradykinin in the porcine renal artery. , International Symposium on New Developments in the Smooth Muscle and Endothelial Cell Signaling, 1999.05.

所属学会名

日本内科学会

日本消化器病学会

日本消化器内視鏡学会

Canadian Association of Gastroenterology

日本平滑筋学会

日本消化管学会

American Gastroenterological Association

日本内科学会

日本消化器病学会

日本消化器内視鏡学会

Canadian Association of Gastroenterology

日本平滑筋学会

日本消化管学会

American Gastroenterological Association

日本内科学会

日本消化器病学会

日本消化器内視鏡学会

日本消化管学会

日本平滑筋学会

日本食道学会

アメリカ消化器病学会

カナダ消化器病学会

学協会役員等への就任

2021.02～2023.01, American Gastroenterological Association, Fellow.

2019.02～2022.01, 日本消化管学会, 評議員.

2018.10～2020.09, 日本消化器病学会, 評議員.

2018.07～2020.06, 日本消化器内視鏡学会, 評議員.

2018.07～2020.06, 日本消化器内視鏡学会, JEDデータ適正使用委員会委員.

2018.08～2019.07, 日本平滑筋学会, 監事.

2014.08～2020.07, 日本平滑筋学会, 評議員.

学会大会・会議・シンポジウム等における役割

2021.04.10～2021.04.10, 日本内科学会ことはじめ　2021東京, 司会（消化器２）.

2021.02.19～2021.02.21, 第17回日本消化管学会総会学術集会, 司会（一般演題 12） .

2020.12.10～2020.12.11, 第71回日本食道学会総会, 司会（パネルディスカッション１　機能性食道疾患の診断と治療 Up to Date）.

2020.12.19～2021.12.20, 第62回日本平滑筋学会総会, 司会（Young Investigator Award).

2020.02.07～2021.02.08, 第16回日本消化管学会総会学術集会, 司会（一般演題 45　食道-1）.

2019.11.21～2019.11.24, 第61回日本消化器病学会大会, （司会）デジタルポスター会場ブース13 その他１.

2019.06～2019.06.06, 第97回日本消化器内視鏡学会, （司会）パネルディスカッション6：食道運動機能障害の診断と治療.

2019.02.01～2019.02.03, 第15回日本消化管学会総会学術集会, （司会）ワークショップ7：消化管生理機能検査法の発展：方法論から機能性消化管疾患研究を切り拓く.

2018.06.08～2018.06.09, 第１１１回日本消化器病学会九州支部例会、第105回日本内視鏡学会九州支部例会, （司会）　ワークショップ2：食道疾患診療のUp to date.

2016.08.17～2016.08.19, 第58回日本平滑筋学会総会, （司会）若手の会シンポジウム：若手から取り組む基礎と臨床の融合〜方法論から平滑筋研究を切り拓く.

2014.03.16～2014.03.18, 第91回日本生理学会大会, （司会）シンポジウム31：消化管免疫-機能連関の病態生理.

2014.05.15～2014.05.17, 第87回日本消化器内視鏡学会, 座長（Chairmanship）.

2013.03.14～2013.03.14, 第445回福岡消化器病研究会, 司会（Moderator）.

2011.02.18～2011.02.18, 2nd Advanced Edoscopic Forum in Fukuoka , 司会（Moderator）.

2010.06.18～2010.06.19, 第95回日本消化器病学会九州支部例会及び第89回日本消化器内視鏡学会九州支部例会, 座長（Chairmanship）.

学会誌・雑誌・著書の編集への参加状況

2019.06～2021.05, Journal of Gastroenterology, 国際, 編集委員.

学術論文等の審査

年度	外国語雑誌査読論文数	日本語雑誌査読論文数	国際会議録査読論文数	国内会議録査読論文数	合計
2020年度	19	1			20
2019年度	9	1			10
2018年度	7	1			8
2017年度	6	0	0	0	6
2016年度	5	1			6
2015年度	5	0	0	0	5
2014年度	6	0	0	0	6
2013年度	6	0	0	0	6

海外渡航状況, 海外での教育研究歴

Department of Biochemistry & Molecular Biology, University of Calgary, Canada, 2005.04～2009.03.

リサーチフェローシップ, 上原記念生命科学財団, 2005.04.

Visiting Speaker & Postdoctoral Recruitment Travel Award_____, The Alberta Heritage Foundation for Medical Research_____, 2005.03.

Canadian Association of Gastroenterology/CIHR/AstraZeneca research initiative award_____, Canadian Association of Gastroenterology_____, 2006.07.

Post-doctoral award of Department of Biochemistry & Molecular Biology_____, University of Calgary_____, 2008.10.

The Pfizer/Smooth Muscle Research Group Post-Doctoral Fellow Research Achievement Award_____, University of Calgary_____, 2009.11.

第10回ふくおか「臨床医学研究賞」_____, 一般財団法人医療・介護・教育研究財団_____, 2016.04.

Scientific accomplishment as an early stage investigator_____, American Gastroenterological Association_____, 2016.05.

The Best Presenter Award in International Session_____, Japanese Digestive Disease Week_____, 2019.11.

Poster of distinction_____, American Gastroenterological Association_____, 2019.05.

Best Discussant 賞, GI bioregulation, 2020.02.

一般演題賞, 日本平滑筋学会, 2021.08.

The Best Presenter Award in International Session, Japanese Digestive Disease Week 2019, 2019.11.

Selected poster of distinction, Digestive Disease Week 2019, 2019.05.

第10回ふくおか「臨床医学研究賞」, 一般財団法人　医療・介護・教育研究財団, 2016.02.

Scientific accomplishment as an early stage investigator, American gastroenterological association, 2016.05.

優秀演題賞, 日本平滑筋学会, 2010.07.

The Pfizer/Smooth Muscle Research Group Post-Doctoral Fellow Research Achievement Award, Smooth Muscle Research Group, University of Calgary, 2009.11.

Post-doctoral award , BMB (Department of Biochemistry & Molecular Biology) at University of Calgary , 2008.10.

Candadian Association of Gastroenterology/CIHR/AstraZeneca research initiative award , Candadian Association of Gastroenterology/CIHR/AstraZeneca, 2006.07.

上原記念生命科学財団リサーチフェローシップ, 上原記念生命科学財団, 2006.03.

Visiting Speaker & Postdoctoral Recruitment Travel Award, Alberta Heritage Foundation for Medical Research (AHFMR) in Canada, 2005.03.

科学研究費補助金の採択状況(文部科学省、日本学術振興会)

2013年度～2015年度, 基盤研究(C), 炎症性腸疾患腸管粘膜におけるsmad7発現亢進のメカニズムと新規治療法の開発.

2016年度～2018年度, 基盤研究(C), 腸内細菌・発酵産物による制御性T細胞表面結合TGF-β発現誘導の研究.

2019年度～2022年度, 基盤研究(C), 自己免疫性自律神経節障害の「多様性」に関する多角的研究.

2020年度～2022年度, 基盤研究(C), 代表, 多角的な視点による各サブタイプに基づいた食道アカラシアの病態解明.

2017年度～2019年度, 基盤研究(C), 代表, サイトカインプロフィール解析による食道アカラシアの病態解明.

2014年度～2016年度, 基盤研究(C), 代表, 下部食道括約筋における筋原性緊張調節機序の解明と新規食道アカラシア治療薬の開発.

2011年度～2012年度, 研究活動スタート支援, 代表, IL-23及びTh17経路が腸管平滑筋収縮機能の与える影響とその作用機序.

競争的資金(受託研究を含む)の採択状況

2020年度～2020年度, 公益財団法人三井住友海上福祉財団, 代表, 食道期の嚥下機能に起因する誤嚥性肺炎の病態解明と食道運動機能に焦点をあてた予防医療の開発.

2021年度～2023年度, 臨床研究・治験推進研究事業　既に作成済みのプロトコルに基づいて実施する医薬品に関する臨床研究・医師主導治験の推進（ステップ２）, 代表, 食道アカラシアの前駆状態とされる食道胃接合部通過障害に対するアコチアミドの有効性と安全性を検討する第II相医師主導治験.

2019年度～2020年度, 公益財団法人テルモ生命科学振興財団, 代表, 消化管運動機能を可視化する内視鏡下消化管活動電図計の開発.

2018年度～2018年度, 公益財団法人大和証券ヘルス財団, 代表, 高齢者の嚥下機能に影響を及ぼす臨床学的因子の探索：食道運動機能の観点から.

2019年度～2019年度, 日本医療開発機構：臨床研究・治験推進研究事業　医薬品開発を目指す臨床研究・医師主導治験のプロトコール作成に関する研究ステップ１, 代表, 食道アカラシアの発症予防としての食道胃接合部通過障害に対する治療法の開発.

2017年度～2020年度, 公益財団法人喫煙科学研究財団研究助成, 代表, 神経性ニコチン受容体を標的とした食道アカラシア及び食道胃接合部通過障害の病態解明.

2016年度～2016年度, 第１０回ふくおか「臨床医学研究賞」, 代表, 非心臓性胸痛の原因となる食道運動異常症の病態解明と新規治療薬の開発.

2014年度～2014年度, 公益財団法人　臨床研究奨励基金　臨床研究助成, 代表, Gasotransmitter, hydrogen sulfate (H2S)を標的とした下部食道括約筋における筋原性緊張調節機序の解明と新規アカラシア治療薬の開発.

共同研究、受託研究(競争的資金を除く)の受入状況

2016.03～2022.02, 分担, 再発・再燃を繰り返す逆流性食道炎の維持療法を実施中の患者を対象に、ボノプラザン10mg又は20mgを長期投与(260週間:5年)した場合の胃粘膜組織への影響及び安全‘性、並びに逆流性食道炎患者を対象にボノプラザン20mg投与による治癒効果をランソプラゾールを対照に探索的に検討する。.


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