| Takahiro A. Kato | Last modified date：2023.10.27 |
Associate Professor /
Department of Neuropsychiatry, Graduate School of Medical Sciences /
Department of Clinical Medicine /
Faculty of Medical Sciences
Books
| 1. | Enomoto S, Kato TA*, Stress, Microglial activation, and Mental disorders. Stress-Related Disorders ［Working Title］, Intech Open, London, UK, 10.5772/intechopen.103784, 2022.04. |
| 2. | Noriaki Sagata, Yasunari Sakai and Takahiro A. Kato, Clarifying the Pathophysiological Mechanisms of Neuronal Abnormalities of NF1 by Induced-Neuronal (iN) Cells from Human Fibroblasts, Intech Open, 10.5772/intechopen.98817, 2021.07. |
| 3. | Takahiro A. Kato, Developmental model of hikikomori: Possible ways to prevent and treat pathological social withdrawal in later life, Elsevier, San Diego, CA, USA, Book Chapter6: pp135-157 Starting at the beginning: Laying the foundation for lifelong mental health, 2019.11. |
| 4. | Norman Sartorius, Naotaka Shinfuku, Heok Eee Kua, Takahiro A. Kato, Alan R. Teo, Masaru Tateno, Tae Young Choi, Yatan Pal Singh Balhara, Shigenobu Kanba, Urban mental health in the twenty-first century, Springer International Publishing, 10.1007/978-3-319-70554-5_38, 657-678, 2018.08. |
| 5. | Mina Sato-Kasai, Takahiro A. Kato, Masahiro Ohgidani, Hideki Horikawa, Yoshito Mizoguchi, Akira Monji, Shigenobu Kanba, Modulating microglial activation as a possible therapeutic target for depression, Springer Singapore, 10.1007/978-981-10-6580-4_18, 1, 209-219, 2018.01. |
| 6. | Takahiro A. Kato, Naotaka Shinfuku, Norman Sartorius, Shigenobu Kanba, Loneliness and single person households:Issues of kodoku-shi and hikikomori in Japan, Springer Singapore, 10.1007/978-981-10-0752-1_9-1, In: “Mental Health and Illness Worldwide: Mental Health and Illness in the City”(pp 1-15), 2017.03, [URL]. |
| 7. | Takahiro A. Kato, Aye M. Myint, Johann Steiner, Minding Glial Cells in the Novel Understandings of Mental Illness, Frontiers Media Lausanne, 2017.02. |
| 8. | Masahiro Ohgidani, Takahiro A. Kato, Yoshito Mizoguchi, Hideki Horikawa, Akira Monji, Shigenobu Kanba, Antidepressants modulate microglia beyond the neurotransmitters doctrine of mood disorders, Springer, New Delhi-India, 10.1007/978-81-322-2803-5_36, In: "Melatonin, Neuroprotective Agents and Antidepressant Therapy” (Chapter 29, pp611-620), 2016.11. |
| 9. | Akira Monji, Izumi Maezawa, Yoshito Mizoguchi, Takahiro A. Kato, Lee Way Jin, Neurodevelopmental and neuropsychiatric disorders, Springer New York, 10.1007/978-1-4939-1429-6_14, 345-372, 2014.07, The etiology of neuropsychiatric disorders such as autism spectrum disorders (ASDs) and schizophrenia remains unclear. However, many aspects of their neuropathology were recently reported to be closely associated with microglial dysfunction. Microglia, which are the major players of innate immunity in the central nervous system, respond rapidly to pathological changes, even minor ones, and contribute directly to neuroinflammation by producing various cytokines and free radicals. Recent studies revealed that microglia become activated over the course of ASDs and schizophrenia, using brain neuroimaging and postmortem analyzes. Recent studies have also shown inhibitory effects of some antipsychotics on the release of inflammatory cytokines and free radicals from activated microglia, causing synaptic and white matter abnormalities as seen in ASDs and schizophrenia postmortem brains. In addition, recent evidence strongly suggests a neurodevelopmental role for microglia in regulating the formation/function of neuronal circuits by their phagocytic activity and structural interactions with synapses. In Rett syndrome (RTT) particularly, microglia become dysfunctional and neurotoxic, thus contributing to abnormal brain development. Populating the brain of RTT mice with wild-type microglia was also found to arrest the disease, indicating an essential role of microglia in regulating the neurodevelopmental trajectory. In summary, emerging evidence indicates that microglia are closely related to the progression and outcome of ASDs and schizophrenia. Understanding microglial pathology may shed new light on the most promising therapeutic strategies for ASDs and schizophrenia, among other neuropsychiatric disorders.. |
| 10. | Alan R. Teo, Kyle W. Stufflebam, Takahiro A. Kato, The Intersection of Culture and Solitude: The Hikikomori Phenomenon in Japan, Wiley-Blackwell, 10.1002/9781118427378.ch25, In: A HANDBOOK OF SOLITUDE: PSYCHOLOGICAL PERSPECTIVES ON SOCIAL ISOLATION, SOCIAL WITHDRAWAL, AND BEING ALONE (Chapter 25: pp445-460), 2013.12, [URL]. |
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