|Takahiro A. Kato||Last modified date：2021.09.10|
Associate Professor / Department of Neuropsychiatry, Graduate School of Medical Sciences / Department of Clinical Medicine / Faculty of Medical Sciences
|Takahiro A. Kato||Last modified date：2021.09.10|
|1.||榎本 真悟、加藤 隆弘, Facing and treating hikikomori (pathological social withdrawal), Quaderni Di Psicoterapia Cognitiva, doi.org/10.3280/qpc48-2021oa12137, 2021.07.|
|2.||Tan F.T.C, Kato TA, Ondrus J, Tan B, Digital transformation and the socially reclusive: A study of ICT and the hikikomori in Japan, 24th Pacific Asia Conference on Information Systems: Information Systems (IS) for the Future, PACIS 2020 (Conference Paper), 2020.06.|
|3.||Kato, T. A,Kanba, S, Teo, A. R., Hikikomori: Multidimensional understanding, assessment and future international perspectives, Psychiatry and clinical neurosciences, 10.1111/pcn.12895, 2019.05.|
|4.||Takahiro A. Kato, Aye M. Myint, Johann Steiner, Editorial
Minding glial cells in the novel understandings of mental illness, Frontiers in Cellular Neuroscience, 10.3389/fncel.2017.00048, 2017.02.
|5.||早川 宏平, 久保 浩明, 近藤 恵子, 藤田 佐和, 加藤 隆弘, 希死念慮をかかえるがん患者へのサポート(第5回) うつ病・「死にたい気持ち」への初期対応法 メンタルヘルス・ファーストエイド(Mental Health First Aid:MHFA), がん看護, 2017.01.|
|6.||Kato TA*, Ohgidani M, Sagata N, Kanba S, Directly induced glial/neuronal cells from human peripheral tissues: A novel translational research for neuropsychiatric disorders, Advances in Neuroimmune Biology, 10.3233/NIB-160109, 2016.11.|
|7.||Kato TA*, Hashimoto R, Hayakawa K, Kubo H, Watabe M, Teo AR, Kanba S, The multidimensional anatomy of “modern type depression” in Japan: A proposal for a different diagnostic approach to depression beyond the DSM-5, Psychiatry and Clinical Neuroscience 70(1), 10.1111/pcn.12360, 2016.01.|
|8.||Ohgidani M, Kato TA*, Kanba S, Introducing directly induced microglia-like (iMG) cells from fresh human monocytes: A novel translational research tool for psychiatric disorders, Frontiers in Cellular Neuroscience , 10.3389/fncel.2015.00184, 2015.05.|
|9.||Kato TA, Introducing Hikikomori from multidimensional perspectives. Interview, World Child & Adolescent Psychiatry, WPA, Child and Adolescent Psychiatry Section's Official Journal, 2014.12.|
|10.||Takahiro A. Kato, Motoki Watabe, Shigenobu Kanba, Neuron-glia interaction as a possible glue to translate the mind-brain gap
A novel multi-dimensional approach toward psychology and psychiatry, Frontiers in Psychiatry, 10.3389/fpsyt.2013.00139, 2013.10, Neurons and synapses have long been the dominant focus of neuroscience, thus the pathophysiology of psychiatric disorders has come to be understood within the neuronal doctrine. However, the majority of cells in the brain are not neurons but glial cells including astrocytes, oligodendrocytes, and microglia. Traditionally, neuroscientists regarded glial functions as simply providing physical support and maintenance for neurons. Thus, in this limited role glia had been long ignored. Recently, glial functions have been gradually investigated, and increasing evidence has suggested that glial cells perform important roles in various brain functions. Digging up the glial functions and further understanding of these crucial cells, and the interaction between neurons and glia may shed new light on clarifying many unknown aspects including the mind-brain gap, and conscious-unconscious relationships. We briefly review the current situation of glial research in the field, and propose a novel translational research with a multi-dimensional model, combining various experimental approaches such as animal studies, in vitro & in vivo neuron-glia studies, a variety of human brain imaging investigations, and psychometric assessments..
|11.||Kato TA*, Hayakawa K, Monji A, Kanba S, Missing and Possible Link between Neuroendocrine Factors, Neuropsychiatric Disorders and Microglia, Frontiers in Integrative Neuroscience, 10.3389/fnint.2013.00053, 2013.07.|
|12.||Kato TA*, Kanba S, Are microglia minding us? Digging up the unconscious mind-brain relationship from a neuropsychoanalytic approach, Frontiers in Human Neuroscience, 10.3389/fnhum.2013.00013, 2013.02.|
|13.||T. A. Kato, Y. Yamauchi, H. Horikawa, A. Monji, Y. Mizoguchi, Y. Seki, K. Hayakawa, H. Utsumi, S. Kanba, Neurotransmitters, psychotropic drugs and microglia
Clinical implications for psychiatry, Current Medicinal Chemistry, 10.2174/092986713804870800, 2013.01, Psychiatric disorders have long and dominantly been regarded to be induced by disturbances of neuronal networks including synapses and neurotransmitters. Thus, the effects of psychotropic drugs such as antipsychotics and antidepressants have been understood to modulate synaptic regulation via receptors and transporters of neurotransmitters such as dopamine and serotonin. Recently, microglia, immunological/inflammatory cells in the brain, have been indicated to have positive links to psychiatric disorders. Positron emission tomography (PET) imaging and postmortem studies have revealed microglial activation in the brain of neuropsychiatric disorders such as schizophrenia, depression and autism. Animal models of neuropsychiatric disorders have revealed the underlying microglial pathologies. In addition, various psychotropic drugs have been suggested to have direct effects on microglia. Until now, the relationship between microglia, neurotransmitters and psychiatric disorders has not been well understood. Therefore, in this review, at first, we summarize recent findings of interaction between microglia and neurotransmitters such as dopamine, serotonin, norepinephrine, acetylcholine and glutamate. Next, we introduce up-to-date knowledge of the effects of psychotropic drugs such as antipsychotics, antidepressants and antiepileptics on microglial modulation. Finally, we propose the possibility that modulating microglia may be a key target in the treatment of various psychiatric disorders. Further investigations and clinical trials should be conducted to clarify this perspective, using animal in vivo studies and imaging studies with human subjects..
|14.||Kotaro Otsuka, Yuriko Suzuki, Daisuke Fujisawa, Takahiro Kato, Ryoko Sato, Kumi Aoyama-Uehara, Naoki Hashimoto, Shimako Suzuki, Mie Kurosawa, [The activities of Mental Health First Aid-Japan Team]., Seishin shinkeigaku zasshi = Psychiatria et neurologia Japonica, 2013.01, The Mental Health First Aid (MHFA) program is a training program for non-health professionals that deals with persons with a mental health crisis (Kitchener & Jorm, 2006). The MHFA-Japan team was established in 2007, and a founding member completed a MHFA training program in Melbourne, University of Australia. We consulted with Jorm and Kitchener, and started a Japanese study of the program. Providing the MHFA program for gatekeepers in Japan could help them assess risk factors and refer patients for professional care, and contribute to suicide prevention. Our team cooperated with the gatekeeper training program of the cabinet office of the Japanese government. In addition, this program is applied in instructional activities in the area of the Great East Japan Earthquake..|
|15.||Kato TA*, Monji A, Mizoguchi Y, Hashioka S, Horikawa H, Seki Y, Kasai M, Utsumi H, Kanba S, Anti-inflammatory properties of antipsychotics via microglia modulations; Are antipsychotics a 'fire extinguisher' in the brain of schizophrenia?, Mini-Reviews in Medicinal Chemistry, 10.2174/138955711795906941, 2011.06.|
|16.||Y. Mizoguchi, A. Monji, T. A. Kato, H. Horikawa, Y. Seki, M. Kasai, S. Kanba, S. Yamada, Possible role of BDNF-induced microglial intracellular ca2+ elevation in the pathophysiology of neuropsychiatric disorders, Mini-Reviews in Medicinal Chemistry, 10.2174/138955711795906932, 2011.06, Microglia are intrinsic immune cells that release factors, including proinflammatory cytokines, nitric oxide (NO) and neurotrophins, following activation after disturbance in the brain. Elevation of intracellular Ca2+ concentration ([Ca2+]i) is important for microglial functions, such as the release of cytokines and NO from activated microglia. There is increasing evidence suggesting that pathophysiology of neuropsychiatric disorders is related to the inflammatory responses mediated by microglia. Brain-derived neurotrophic factor (BDNF) is a neurotrophin well known for its roles in the activation of microglia as well as in pathophysiology and/or treatment of neuropsychiatric disorders. We have recently reported that BDNF induces a sustained increase in [Ca2+]i through binding with the truncated TrkB receptor, resulting in activation of the PLC pathway and store-operated calcium entry (SOCE) in rodent microglial cells. Sustained activation of SOCE, possibly mediated by TRP channels, occurred after brief BDNF application and contributed to the maintenance of sustained [Ca2+]i elevation. Pretreatment with BDNF significantly suppressed the release of NO from activated microglia. Additionally, selective serotonin reuptake inhibitors (SSRIs), including paroxetine or sertraline, potentiated the BDNFinduced increase in [Ca2+]i in rodent microglial cells This article provides a review of recent findings on the role of BDNF in the pathophysiology of neuropsychiatric disorders, especially by focusing on its effect on intracellular Ca2+ signaling in microglial cells..|
|17.||Wakako Umene-Nakano, Naoki Uchida, Takahiro Kato, Masaru Tateno, Ryohei Matsumoto, Jun Nakamura, [Views on the new psychiatric specialist certification system from the perspective of those experiencing the postgraduate psychiatric training system in Japan]., Seishin shinkeigaku zasshi = Psychiatria et neurologia Japonica, 2011.06, The psychiatric specialist certification system of the Japanese Society of Psychiatry and Neurology was established in 2005, with a transitional period that ran until 2008. A three-year postgraduate training scheme was started in connection with the new psychiatric specialist certification system, and the first formal examination under the new system was held in 2010. A resident desiring certification as a psychiatric specialist must purchase a psychiatric specialist certification handbook and present it when taking the examination. There are many differences between the new examination and the transitional period examination, in terms of both the handbook and the number of case reports to be submitted. Results of a survey conducted on 360 psychiatrists belonging to either university or national hospitals, all of whom had undergone psychiatric training within the past eight years, revealed that there was currently a lack of knowledge, and low rate of utilization, of the handbook. The primary author was in the first cohort of those who began postgraduate psychiatric training in a university hospital and subsequently took the first examination administered after the transition period. The author has maintained that, based on personal experience, a number of issues need improvement, such as the large number of grading items to be signed off on by supervising psychiatrists, and complications involving the outline of cases to be experienced. Additionally, it was thought to be difficult for supervisors who had obtained their specialist certification via the transitional period examination to have an adequate understanding of the outline of the new examination. Therefore, it is important that residents themselves take a more assertive attitude to becoming specialists. In the future, in order to establish a sound specialist certification system, the results of this survey of physicians who took the new examination should be taken into account..|
|18.||Wakako Umene-Nakano, Takahiro Kato, Masaru Tateno, Tsutomu Hoshuyama, Jun Nakamura, Issues and the current situation of the new compulsory residency training program in Japan
the results of an attitude survey for young career psychiatrists, Seishin shinkeigaku zasshi = Psychiatria et neurologia Japonica, 2010.04, The new 2 year compulsory residency training program, which includes rotation to each department and requires 1 month of psychiatric training for all residents, started in April 2004 in Japan. In August to September belonging 2008, we conducted an attitude survey of psychiatrists with 10 or fewer years of experience to 15 institutions to clarify the problems and present condition of primary psychiatric training. Psychiatrists (92%) who experienced the new residency program were satisfied with it, and 41% decided to become a psychiatrist after the primary psychiatric training. We compared the training periods and training institutions. Psychiatrists who experienced training for 3 months or more rate themselves higher with regard to pharmacotherapy, and those who underwent training in private psychiatric hospitals rate themselves higher with regard to their understanding of psychiatric disorders. It was suggested that the introduction of primary psychiatric training has promoted motivation to become a psychiatrist and that the length of the training period and type of institution lead to differences in the acquisition of psychiatric skills. Psychiatrists who train residents thought that the skill that residents most needed to acquire was intervention for suicidal patients, but, for residents, this was the least useful item in their training. It was suggested that, in the current situation, there is an insufficient acquisition of learning items. In 2010, psychiatric rotation will change from a required to an elective subject, but residents will still have the opportunity to select it. We need to consider how to devise a short-term but effective primary psychiatric training program in which residents can acquire the basics of primary care psychiatry..
|19.||Monji A*, Kato T, Kanba S, Cytokines and Schizophrenia-Microglia Hypothesis of Schizophrenia-, Psychiatry and Clinical Neurosciences, 10.1111/j.1440-1819.2009.01945.x, 2009.05.|
|20.||Akira Monji, Ken Ichiro Tashiro, Ichiro Yoshida, Sadayuki Hashioka, Takahiro Kato, Shigenobu Kanba, Laminin and its related peptides for the treatment of Alzheimer's disease, Current Medicinal Chemistry - Central Nervous System Agents, 10.2174/156801505774913017, 2005.12, Alzheimer's disease (AD) is one type of dementing central nervous amyloidosis characterized by two different types of fibrillar deposits, namely senile plaques and neurofibrillary tangles. Amyloid-β-proteins (Aβ) are the major constituents of senile plaques. The aggregation of soluble Aβ into insoluble amyloid fibrils is believed to be an important step in the pathogenesis of AD and the prevention of this process therefore seems to be a promising strategy for the treatment of AD. Laminin is an important extracellular matrix (ECM) protein which has been reported to accumulate in the senile plaques. It supports such biological activities as cell adhesion, cell proliferation, neurite outgrowth. Recent reports have revealed that laminin inhibits both Aβ fibril formation and Aβ neurotoxicity in vitro. Laminin-related peptides, which have almost the same biological activities as laminin, have also recently been reported to inhibit Aβ fibril formation and/or Aβ neurotoxicity. Finally, Laminin can induce a complete disaggregation of Aβ amyloid fibrils by disassembly into protofibrils and subsequently into an amorphous aggregate. These results thus suggested that laminin or its related peptides may be useful as an effective therapeutic agent for the treatment of AD..|