Kyushu University Academic Staff Educational and Research Activities Database
List of Presentations
Hiroyuki Honda Last modified date:2020.07.08

Associate Professor / Department of neuropathology, neurological institute / Department of Basic Medicine / Faculty of Medical Sciences

1. Honda H, Hamasaki H, Okamoto T, Ninomiya T, Iwaki T, Trends in dementia prevalence over 31 years of the Hisayama study, International Congress of Neuropathology, 2018.07, Introduction: In Japan, dementia has become a serious social problem. The Hisayama study is a prospective cohort study of lifestyle-related diseases including dementia that was started in1961. In the population-based study, it has been reported that all-cause dementia and Alzheimer’s disease (AD) significantly increased in recent years.
Methods: The aim of this study is to clarify the trends in dementia using data from 1371 autopsied performed over the past 31 years (1986-2016). Throughout the whole period, the autopsy rate is about 75%. We divided the 1371 autopsy samples into five groups according to the year of death: I (1986–1991, 257 cases), II (1992–1997, 268 cases), III (1998–2004, 318 cases), IV (2005–2011, 296 cases), and V (2012–2016, 232 cases). In addition, we investigated the increases in brain pathology related to AD using automated morphometric analyses for quantifying tau pathology.
Results: The prevalence of all-cause and AD significantly increased. A significant increasing trend was observed in both men and women. A rapid increase in senile dementia of the NFT type (SD-NFT) in recent years was notable. The morphometric analyses revealed a significant increasing of tau pathology in recent years. The significance was also observed regardless of the senile plaques.
Conclusion: We revealed a recent trend of increased tauopathy such as AD and SD-NFT, which is partly independent of amyloid-β pathology. Although aging is considered one of the important risk factors accelerating tau pathology, there could be other risk factors associated with lifestyle diseases..
2. 濱崎 英臣, 本田 裕之, 鈴木 諭, 岩城 徹, Altered expression of c-Met in Alzheimer’s disease brains., 第35回日本分子生物学会, 2012.12.